JP2017217274A - Blood purification apparatus and method of checking connection of the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood purification apparatus capable of more quickly and more accurately executing a connection checking process to check pass/fail of blood circuit connection, also to provide a method of checking the connection of the blood purification apparatus.SOLUTION: The blood purification apparatus comprises: a blood circuit; a dialyzer 1; a bubble detection sensor 16 capable of detecting bubbles in a liquid flowing through the blood circuit; and control means 17 capable of causing a priming liquid to be supplied into the blood circuit so that the blood circuit is primed, and also causing the execution of a connection checking process to check pass/fail of the connection of the blood circuit. Before causing the execution of the connection checking process, the control means 17 causes a negative pressure to be applied into the blood circuit and determines whether or not bubbles are detected by the bubble detection sensor 16, provided that the priming liquid has been filled in the blood circuit.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a blood purification apparatus for performing blood purification treatment with a blood purifier connected to a blood circuit, and a connection confirmation method thereof.

  The blood circuit of the blood purification apparatus is usually configured so that the patient's blood can be circulated extracorporeally after being filled with the priming liquid by priming. In recent blood purification apparatuses, a device that performs a connection confirmation process for confirming whether or not the blood circuit is normally connected when priming is performed has been proposed (for example, Patent Document 1, 2). In the conventional connection confirmation step, the blood pump is pressurized by driving a replacement fluid pump, a duplex pump, etc., and whether or not the pressure detection means disposed in the blood circuit results in a pressure exceeding a predetermined value, Is performed by determining whether or not the pressure value is maintained for a certain time after the pressurization is stopped.

JP 2011-161060 A JP2012-192101A

  However, in the above-described conventional blood purification apparatus, in the case where there is an unconnected portion that is close to the atmosphere, it is possible to easily determine the connection failure, but to determine a connection failure that causes a slight loosening of the connection portion. However, it is necessary to pressurize until a higher pressure is reached, or it is necessary to monitor whether or not a constant pressure is maintained for a longer time. Therefore, in order to perform the connection confirmation with higher accuracy, there is a problem that it is necessary to extend the time for the connection confirmation process.

  The present invention has been made in view of such circumstances, and a blood purification apparatus capable of performing a connection confirmation step for confirming the quality of a blood circuit connection in a shorter time and with higher accuracy, and its connection confirmation. It is to provide a method.

  According to the first aspect of the present invention, there is provided a blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating a patient's blood, and the blood connected between the arterial blood circuit and the venous blood circuit. Blood purification means for purifying blood flowing in the circuit; bubble detection means capable of detecting bubbles in the liquid flowing in the blood circuit; and priming liquid is supplied to the blood circuit to prime the blood circuit And a control means capable of performing a connection confirmation step for confirming the quality of the connection of the blood circuit, wherein the control means fills the blood circuit with a priming liquid. If the negative pressure is applied to the blood circuit, it is possible to perform the connection confirmation step by determining whether or not a bubble is detected by the bubble detection means. And features.

  According to a second aspect of the present invention, in the blood purification apparatus according to the first aspect, a plurality of the bubble detection means are arranged in the blood circuit and can detect bubbles at a plurality of locations, and the control means A connection failure location can be specified according to the detected bubble detection means.

  According to a third aspect of the present invention, in the blood purification apparatus according to the first or second aspect, the control means applies a negative pressure while allowing the dialysate to flow in a dialysate flow path formed in the blood purification means. Thus, the negative pressure can be applied to the blood circuit.

  According to a fourth aspect of the present invention, in the blood purification apparatus according to the first or second aspect, the control means includes a blood pump disposed in the arterial blood circuit while closing a predetermined position of the blood circuit. The negative pressure can be applied to the blood circuit by being driven.

  According to a fifth aspect of the present invention, in the blood purification apparatus according to any one of the first to fourth aspects, the control means fills a priming liquid into the blood circuit, and the priming liquid A circulation cleaning step of circulating the priming solution filled in the filling step in the blood circuit can be sequentially performed, and the connection confirmation step is performed in the circulation cleaning step.

  According to a sixth aspect of the present invention, there is provided a blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating a patient's blood, and the blood connected between the arterial blood circuit and the venous blood circuit. Blood purification means for purifying blood flowing in the circuit; bubble detection means capable of detecting bubbles in the liquid flowing in the blood circuit; and priming liquid is supplied to the blood circuit to prime the blood circuit A blood purification apparatus connection confirmation method comprising: a control means capable of performing a connection confirmation step for confirming whether the connection of the blood circuit is good or not, wherein the blood circuit is filled with a priming solution On the condition, a negative pressure is applied to the blood circuit, and it is determined whether or not air bubbles are detected by the air bubble detecting means, and a blood circuit connection confirmation step is performed. And features.

  The invention according to claim 7 is the blood purification apparatus connection confirmation method according to claim 6, wherein a plurality of the bubble detecting means are arranged in the blood circuit and can detect bubbles at a plurality of locations, and the bubbles are detected. It is characterized in that a poorly connected part can be specified according to the bubble detection means.

  According to an eighth aspect of the present invention, in the blood purification apparatus connection confirmation method according to the sixth or seventh aspect, the negative pressure is caused while the dialysate flows in the dialysate flow path formed in the blood purification means. Thus, the negative pressure can be applied to the blood circuit.

  According to a ninth aspect of the present invention, in the blood purification apparatus connection confirmation method according to the sixth or seventh aspect, the blood pump disposed in the arterial blood circuit is driven while closing a predetermined position of the blood circuit. The negative pressure can be applied to the blood circuit.

  A tenth aspect of the present invention is the blood purification apparatus connection confirmation method according to any one of the sixth to ninth aspects, wherein a priming liquid filling step of filling the blood circuit with a priming liquid, and the filling of the priming liquid A circulation cleaning step of circulating the priming solution filled in the step in the blood circuit can be sequentially performed, and the connection confirmation step is performed during the circulation cleaning step.

  According to the first and sixth aspects of the invention, on the condition that the priming liquid is filled in the blood circuit, a negative pressure is applied to the blood circuit, and whether or not bubbles are detected by the bubble detecting means. Therefore, the blood circuit connection confirmation step is performed, so that the connection confirmation step for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy.

  According to the second and seventh aspects of the present invention, a plurality of bubble detecting means are arranged in the blood circuit and can detect bubbles at a plurality of locations, and a defective connection location is determined according to the bubble detecting means where the bubbles are detected. Since it can be specified, it is possible to more quickly and smoothly deal with after the connection failure is confirmed.

  According to the inventions of claims 3 and 8, a negative pressure can be applied in the blood circuit by applying a negative pressure while flowing the dialysate in the dialysate flow path formed in the blood purification means. The connection confirmation step can be performed using a phenomenon in which a negative pressure is generated during the gas purge step of filling the dialysate into the flow path.

  According to the fourth and ninth aspects of the present invention, the negative pressure can be applied to the blood circuit by driving the blood pump disposed in the arterial blood circuit while closing the predetermined position of the blood circuit. The connection confirmation process can be easily performed during or after priming.

  According to the fifth and tenth aspects of the invention, the priming solution filling step for filling the blood circuit with the priming solution, and the circulation washing step for circulating the priming solution filled in the priming solution filling step in the blood circuit are provided. Since the connection confirmation process can be performed at the time of the circulation washing process, the connection confirmation process can be favorably performed in the circulation washing process of the blood circuit priming process.

1 is a schematic diagram showing a hemodialysis apparatus (blood purification apparatus) according to a first embodiment of the present invention. Flow chart showing control contents at the time of connection confirmation in the hemodialysis apparatus Schematic diagram showing the state when blood circuit connection is confirmed in the hemodialysis machine (when connection is confirmed by pressurization) Schematic diagram showing the state of blood circuit priming (overflow process: filling process) in the hemodialysis machine Schematic diagram showing the state of blood circuit priming (liquid feeding process: filling process) in the hemodialyzer Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis device The schematic diagram which shows the state at the time of the washing | cleaning process of the blood circuit in the hemodialysis apparatus The schematic diagram which shows the hemodialysis apparatus (blood purification apparatus) which concerns on the 2nd Embodiment of this invention. Flow chart showing control contents at the time of connection confirmation in the hemodialysis apparatus Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis device The flowchart which shows the control content at the time of the connection confirmation in the hemodialysis apparatus (blood purification apparatus) which concerns on the 3rd Embodiment of this invention. Schematic showing the state when negative pressure is applied in the hemodialysis machine Schematic diagram showing the state of the circulation washing process of the blood circuit in the hemodialysis device The flowchart which shows the control content at the time of the connection confirmation in the hemodialysis apparatus (blood purification apparatus) which concerns on the 4th Embodiment of this invention. Schematic diagram showing the state when blood circuit connection is confirmed in the hemodialysis machine (when connection is confirmed by pressurization) Schematic diagram showing the state during priming of the blood circuit in the hemodialysis apparatus (priming liquid filling step for the priming liquid supply line) The schematic diagram which shows the state at the time of priming of the blood circuit in the hemodialysis apparatus (filling process of the priming liquid with respect to the blood circuit), and the state at the time of priming of the blood circuit in the hemodialysis apparatus (circulation washing process) Schematic diagram showing the state during priming of the blood circuit (gas purge process) in the hemodialysis device Schematic showing the state when negative pressure is applied in the dialysis machine Schematic showing the state of the priming solution circulation process in the dialysis machine

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification apparatus according to the first embodiment is applied to a hemodialysis apparatus. As shown in FIG. 1, an arterial blood circuit 2 and a venous blood circuit 3 are connected to a dialyzer 1 as blood purification means. The main circuit includes a blood circuit, a dialyzer body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming fluid supply line La, a bubble detection sensor 16 as a bubble detection means, and a control means 17. It is configured.

  The dialyzer 1 includes a blood purification membrane (not shown) (in this embodiment, a hollow fiber type hemodiafiltration membrane, but includes a flat membrane type hemodialysis membrane or a blood filtration membrane) and introduces blood. The blood inlet 1a and the blood outlet 1b for leading the introduced blood are formed, and the dialysate inlet 1c for introducing the dialysate and the dialysate outlet 1d for discharging the introduced dialysate are formed. The dialysate is brought into contact with the blood introduced from the blood introduction port 1a through the hollow fiber membrane to purify the blood.

  The arterial blood circuit 2 is mainly composed of a flexible tube, one end of which is connected to the blood inlet 1a of the dialyzer 1 and guides blood collected from the blood vessel of the patient into the hollow fiber membrane of the dialyzer 1. A connector a to which an arterial puncture needle (not shown) can be attached is formed at the other end of the arterial blood circuit 2, and an arterial air trap chamber 5 for defoaming is connected in the middle. A blood pump 4 is provided. The blood pump 4 is a squeezing type pump (with a structure in which a flexible tube is squeezed to rotate the blood from the arterial puncture needle side toward the blood inlet 1a of the dialyzer 1 when rotated forward). .

  Similar to the arterial blood circuit 2, the venous blood circuit 3 is mainly composed of a flexible tube, and one end of the venous blood circuit 3 is connected to the blood outlet 1b of the dialyzer 1 to derive blood that has passed through the hollow fiber membrane. is there. At the other end of the venous blood circuit 3, a connector b to which a venous puncture needle (not shown) can be attached is formed, and a venous air trap chamber 6 for defoaming is connected midway. . That is, the blood of the patient collected by the arterial puncture needle reaches the dialyzer 1 via the arterial blood circuit 2, and after blood purification, flows through the venous blood circuit 3 and passes through the venous puncture needle. Thus, it is configured to return to the patient's body, thereby providing extracorporeal circulation.

  Further, a bubble detection sensor 16 (bubble detection unit) is attached between the clamping unit Vb and the vein side air trap chamber 6 in the vein side blood circuit 3. The bubble detecting means 16 is composed of a sensor capable of detecting bubbles (air) in the liquid flowing in the blood circuit, and has a pair of ultrasonic vibration elements (oscillating means and receiving means) made up of piezoelectric elements, for example. Has been.

  Specifically, an ultrasonic wave can be irradiated from an ultrasonic vibration element as an oscillating means toward a flexible tube constituting the blood circuit (venous blood circuit 3), and the vibration is an ultrasonic wave as a receiving means. It can be received by the receiving element. The ultrasonic receiving element that receives this vibration is configured so that the voltage changes according to the vibration, and detects that the bubble in the liquid has flowed when the detected voltage exceeds a predetermined threshold. Configured to get.

  The distal end side of the arterial blood circuit 2 (between the connector a and the blood pump 4 and in the vicinity of the connector a) is connected with clamping means Va capable of opening and closing the flow path, and the venous blood circuit 3 A clamp means Vb capable of opening and closing the flow path is connected to the distal end side (between the connector b and the vein-side air trap chamber 6 and in the vicinity of the connector b). An overflow line Lb extends from the upper part of the venous air trap chamber 6 formed in the middle of the venous blood circuit 3, and clamping means that can open and close the flow path in the middle of the overflow line Lb. Vd is connected.

  Before the dialysis treatment, as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected to each other. A closed circuit on the blood circuit side can be formed by the side blood circuit 2 and the vein side blood circuit 3 (including a blood flow path through which blood in the dialyzer 1 flows). Then, the dialysate as the priming solution is supplied into the closed circuit through the priming solution supply line La, so that the dialysate is filled in the blood circuit (arterial blood circuit 2 and venous blood circuit 3). Priming work is possible. In the course of the priming operation, the dialysate can overflow from the overflow line Lb to wash the inside of the closed circuit on the blood circuit side.

  The venous air trap chamber 6 detects the fluid pressure (venous pressure) in the venous blood circuit 3 by detecting the pressure of the air layer formed on the upper side during the extracorporeal circulation of blood by the blood circuit. A resulting venous pressure sensor 13 is attached. When blood purification treatment is started and the patient's blood is circulated extracorporeally in the blood circuit, the venous pressure detected by the venous pressure sensor 13 can be monitored.

  End portions of a dialysate introduction line L1 and a dialysate discharge line L2 are respectively connected to the dialysate introduction port 1c and the dialysate discharge port 1d of the dialyzer 1, and are connected to the dialyzer 1 through the dialysate introduction line L1. The introduced dialysate passes through the outside of the hollow fiber membrane and is discharged from the dialysate discharge line L2. Thus, the inside of the hollow fiber membrane (purification membrane) in the dialyzer 1 forms a blood flow path through which blood can flow, and the outside of the hollow fiber membrane forms a dialysate flow path through which dialysate can flow. It is supposed to be.

  In addition, a dual pump 7 for introducing the dialysate into the dialyzer 1 through the dialysate introduction line L1 and discharging the dialysate from the dialyzer 1 is disposed in the dialyzer body B. The dialyzer main body B has a dialysate introduction line L1 and a dialysate discharge line L2, and has a dual pump 7, bypass lines L3 to L6, and electromagnetic valves V1 to V7. Among these, the duplex pump 7 is disposed across the dialysate introduction line L1 and the dialysate discharge line L2, and introduces dialysate prepared to a predetermined concentration into the dialyzer 1 and dialysates after dialyzing from the dialyzer 1 Are to be discharged.

  A solenoid valve V1 is connected to the middle of the dialysate introduction line L1 (on the downstream side (dialyzer 1 side) from the connecting portion with the priming solution supply line La in the dialysate introduction line L1). A solenoid valve V2 is connected on the way (upstream side (dialyzer 1 side) of the dialysate discharge line L2 connected to the bypass line L3). In addition, filtration filters 8 and 9 are connected between the dual pump 7 and the solenoid valve V1 in the dialysate introduction line L1.

  The filtration filters 8 and 9 are for filtering and purifying the dialysate flowing through the dialysate introduction line L1, and the filtration filters 8 and 9 bypass the dialysate discharge line L2 to guide the dialysate. Bypass lines L3 and L4 are connected to each other. Solenoid valves V3 and V4 are connected to the bypass lines L3 and L4, respectively. An electromagnetic valve V6 is connected between the filtration filter 8 and the filtration filter 9 in the dialysate introduction line L1.

  On the other hand, a fluid pressure measuring sensor 12 capable of measuring the fluid pressure of the dialysate is attached between the connecting portion with the bypass line L3 and the connecting portion with the bypass line L4 in the dialysate discharge line L2. Furthermore, the dialysate discharge line L2 is connected to bypass lines L5 and L6 that bypass the drain side of the duplex pump 7, respectively, and the bypass line L5 removes water from the blood of the patient flowing in the dialyzer 1. In addition, a dewatering pump 10 is provided, and an electromagnetic valve V5 that can open and close the flow path is connected to the bypass line L6.

  Further, on the upstream side of the dual pump 7 in the dialysate discharge line L <b> 2 (between the connecting portion of the bypass line L <b> 5 and the dual pump 7), pressurization for adjusting the hydraulic pressure on the drain side of the dual pump 7 A pump 14 is provided. Further, a degassing chamber 15 is connected upstream of the dual pump 7 in the dialysate discharge line L2 (between the pressurizing pump 14 and the dual pump 7), and a check valve or the like is connected to the degas chamber 15. Is connected to the atmosphere opening line L7, and an electromagnetic valve V7 is connected to the atmosphere opening line L7.

  The priming fluid supply line La has one end connected to the sampling port 11 (so-called sampling port) formed in the dialysate introduction line L1 and the other end connected to the arterial blood circuit 2 (or venous blood circuit 3). The dialysis fluid in the dialysis fluid introduction line L1 may be supplied to the arterial blood circuit 2 (or the venous blood circuit 3) as a priming fluid. The priming liquid supply line La is provided with clamping means Vc capable of opening and closing the flow path. When the blood circuit is primed, the clamping means Vc is opened to enable the clamping circuit Vc to be opened via the priming liquid supply line La. Thus, the dialysate can be supplied to the blood circuit for filling.

  The control means 17 is composed of, for example, a microcomputer or the like disposed in the dialysis apparatus main body B, and controls the opening / closing of arbitrary electromagnetic valves V1 to V7 and the driving or stopping of arbitrary actuators such as the duplex pump 7 and blood pump 4. And is electrically connected to the fluid pressure measurement sensor 12, the venous pressure sensor 13, the bubble detection sensor 16 (bubble detection means), and the like. In the present embodiment, a priming solution (dialysis solution) can be supplied to the blood circuit to perform priming of the blood circuit, and a connection confirmation step for confirming whether the blood circuit is connected or not is performed. It can be used.

  Here, the control means 17 according to the present embodiment applies a negative pressure to the blood circuit on the condition that the priming fluid (dialysis fluid) is filled in the blood circuit, and at the bubble detection sensor 16 A connection confirmation step can be performed by determining whether or not bubbles are detected. In particular, the control means 17 according to the present embodiment can apply a negative pressure in the blood circuit by making the negative pressure while allowing the dialysate to flow (gas purge) in the dialysate flow path formed in the dialyzer 1. It is configured.

  Further, the control means 17 according to the present embodiment includes a priming liquid filling process (overflow process and liquid feeding process) for filling the blood circuit with a priming liquid (dialysis liquid), and the priming filled in the priming liquid filling process. Priming can be performed by sequentially performing a circulation cleaning process for circulating the liquid in the blood circuit, and a connection confirmation process is performed during the circulation cleaning process.

Hereinafter, the control contents of the control means 17 according to the present embodiment will be described based on the flowchart of FIG. 2 and FIGS. 3 to 7.
First, before dialysis treatment (before priming), as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected, A closed circuit on the blood circuit side is formed by the arterial blood circuit 2 and the venous blood circuit 3 (including a flow path through which blood in the dialyzer 1 flows).

  Thereafter, the blood circuit connection is confirmed by pressurizing the blood circuit (S1). In S1, as shown in FIG. 3, the clamp means (Va, Vd) on the blood circuit side are closed and the clamp means (Vb, Vc) are opened, and the solenoid valve (dialyzer main body B side) V1, V2, V4, V7) are closed and the solenoid valves (V3, V5, V6) are opened. Then, by driving the compound pump 7 while driving the blood pump 4 to rotate in the forward direction (rotating direction in which blood flows during blood purification treatment), the dialysate in the dialysate introduction line L1 is supplied to the blood via the priming solution supply line La. Supply into the circuit and pressurize the blood circuit.

  After the blood pump 4 is rotated forward for a set flow rate or time, the blood pump 4 is stopped and the fluid pressure in the blood circuit is detected by the venous pressure sensor 13, and the detected value does not exceed a predetermined threshold value. In the case, it is determined that there is an unconnected part and notified. Further, even when the fluid pressure detected by the venous pressure sensor 13 exceeds a predetermined threshold, if the detected value is not held for a predetermined time (for example, 2 seconds), it is determined that there is an unconnected portion and a notification is made. To do.

  After confirming the connection of the blood circuit in S1, the process proceeds to S2, and priming of the blood circuit (see FIGS. 4 and 5) is performed. In such priming, as shown in FIG. 4, the clamping means (Va to Vd) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the dialyzer main body B side are closed and electromagnetic. Open the valves (V5, V6). Then, by driving the dual pump 7 while stopping the blood pump 4, the dialysate in the dialysate introduction line L1 is supplied as the priming solution to the venous blood circuit 3 side via the priming solution supply line La, and overflow Overflow from line Lb. This process constitutes an overflow process in the priming liquid filling process.

  When the priming solution is supplied to the venous blood circuit 3 side for a predetermined time or at a predetermined flow rate, as shown in FIG. 5, the clamping means (Vc, Vd) on the blood circuit side are closed and the clamping means (Va, Vb) ) Are opened, and the solenoid valves (V1, V2, V4, V7) on the dialyzer body B side are closed and the solenoid valves (V3, V5, V6) are opened. Then, the dialysis fluid introduction line L1 is driven via the priming fluid supply line La by driving the duplex pump 7 while the blood pump 4 is driven to rotate backward (rotation direction opposite to the direction in which blood flows during blood purification treatment). The dialysis solution is supplied as a priming solution to the arterial blood circuit 2 side, and the air in the dialyzer 1 is moved to the venous blood circuit 3 side. This process is a liquid feeding process in the priming liquid filling process.

  In the liquid feeding process (see FIG. 5), after the bubble detection sensor 16 detects the bubbles (air), the blood pump 4 is driven at a predetermined flow rate, and the overflow process (see FIG. 4) is performed again. As described above, when the overflow process and the liquid feeding process are alternately and repeatedly performed a predetermined number of times, the priming S2 of the blood circuit is completed and the process proceeds to S3. As shown in FIG. 6, S3 is a process for starting a circulation cleaning process for circulating the priming liquid in the blood circuit by driving the blood pump 4 to rotate forward.

  In such a circulation washing step, as shown in the figure, the clamp means (Vc, Vd) on the blood circuit side are closed and the clamp means (Va, Vb) are opened, and the electromagnet on the dialyzer main body B side is opened. The valves (V3, V4) are closed and the solenoid valves (V1, V2, V5 to V7) are opened. Then, the double pump 7 is driven while the blood pump 4 is driven to rotate forward, whereby the dialysate flows (gas purge) in the dialysate flow path in the dialyzer 1 while circulating the priming liquid in the blood circuit.

  Here, in the circulation washing step, the electromagnetic valve V7 of the atmosphere release line L7 and the electromagnetic valve V5 of the bypass line L6 are opened while the dialysate flows in the dialysate flow path in the dialyzer 1. A negative pressure is applied to the blood circuit through the flow path, and the process proceeds to S4, where a blood circuit connection confirmation step is performed to determine whether or not bubbles are detected by the bubble detection sensor 16. That is, since the blood circuit is set to a negative pressure, if there is a connection failure at any location in the blood circuit, air is sucked from the connection failure portion and bubbles are generated. By monitoring the bubbles with the detection sensor 16, the presence or absence of a connection failure can be confirmed.

  And when it determines with the bubble being detected in S4, it progresses to S5 and the alarm for making a periphery grasp | ascertain a connection failure is generated. Such an alarm displays a warning on a liquid crystal monitor or the like of the dialyzer main body B, generates a warning sound from a speaker attached to the dialyzer main body B, and lights or blinks a warning light extending upward from the dialyzer main body B Any form may be used.

  After it is determined in S4 that bubbles are not detected or an alarm is generated in S5, the process proceeds to S6, and in-circuit cleaning is continued. In the in-circuit washing step S6, as shown in FIG. 7, the clamp means (Va to Vd) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the dialyzer body B side are closed. The state and solenoid valves (V5, V6) are opened. Then, the double pump 7 is driven while the blood pump 4 is driven to rotate in the forward direction, thereby circulating the dialysis solution as the priming solution in the blood circuit. This completes a series of controls including priming.

  According to the present embodiment, on the condition that the priming liquid is filled in the blood circuit, a negative pressure is applied to the blood circuit, and bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since the blood circuit connection confirmation process is performed by determining whether or not the blood circuit is connected, the connection confirmation process for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy. The bubble detection sensor 16 detects bubbles when the blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned to the patient from the blood circuit after the blood purification treatment and returned to the patient. Since the blood return can be stopped or terminated, the function of preventing air bubbles from entering the patient and the function of confirming the connection can be combined.

  In addition, a negative pressure can be applied to the blood circuit by making the negative pressure while allowing the dialysate to flow in the dialysate flow path formed in the dialyzer 1 (blood purification means). The connection confirmation step can be performed by utilizing a phenomenon in which a negative pressure is generated during the gas purge step of filling the liquid. That is, in the gas purging process, in order to prevent the dual pump 7 from sucking bubbles discharged from the dialysate flow path in the dialyzer 1, the bubbles are captured in the degassing chamber 15 and the electromagnetic valve V7 is set. In the open state, the air bubbles are discharged from the air release line L7 to the outside, and a phenomenon occurs in which a negative pressure is applied to the blood circuit via the dialysate flow path. According to this embodiment, this phenomenon can be used to apply a negative pressure to the blood circuit during the connection confirmation process. When only the electromagnetic valve V7 is opened, an excessive negative pressure is generated on the blood circuit side due to the influence of the pressurizing pump 14. Therefore, in the present embodiment, excessive negative pressure is avoided by opening the electromagnetic valve V5 and opening the bypass line L6 that bypasses the pressurizing pump 14 to the atmosphere.

  Further, according to the present embodiment, the priming liquid filling process for filling the blood circuit with the priming liquid and the circulation washing process for circulating the priming liquid filled in the priming liquid filling process in the blood circuit are sequentially performed. In addition, since the connection confirmation process is performed during the circulation washing process, the connection confirmation process can be favorably performed in the circulation washing process of the blood circuit priming process.

Next, a blood purification apparatus according to a second embodiment of the present invention will be described.
As in the first embodiment, the blood purification apparatus according to this embodiment is applied to a hemodialysis apparatus. As shown in FIG. 8, the blood purification device includes a dialyzer 1 serving as a blood purification means and an arterial blood circuit 2 and A blood circuit to which the venous blood circuit 3 is connected, a dialyzer body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming fluid supply line La, and a bubble detection sensor (16a 16b) and the control means 17. In addition, the same code | symbol is attached | subjected to the component same as 1st Embodiment, and those description is abbreviate | omitted.

  In the present embodiment, a plurality of bubble detection sensors (16a, 16b) are arranged in the blood circuit (two in the present embodiment) and can detect bubbles at a plurality of locations (two in the present embodiment). At the same time, it is configured such that a poorly connected portion can be specified in accordance with the bubble detection sensors (16a, 16b) in which bubbles are detected. Specifically, the bubble detection sensors (16a, 16b) can detect bubbles in the liquid flowing in the blood circuit, as in the previous embodiment, and the bubble detection sensor 16a is used for the arterial blood circuit 2. It is attached to the distal end (between the connecting portion with the priming liquid supply line La and the clamping means Va), and the bubble detection sensor 16b is connected to the distal end of the venous blood circuit 3 (the venous air trap chamber 6 and the clamping means Vb). Between).

Hereinafter, the control contents of the control means 17 according to the present embodiment will be described based on the flowchart of FIG. 9 and FIG. 10.
First, before dialysis treatment (before priming), as shown in FIG. 8, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected, A closed circuit on the blood circuit side is formed by the arterial blood circuit 2 and the venous blood circuit 3 (including a flow path through which blood in the dialyzer 1 flows).

  Thereafter, the blood circuit connection confirmation (S1) and the blood circuit priming (S2) are performed by pressurization, and then the process proceeds to S3 to start the circulation cleaning process. Note that the blood circuit connection confirmation (S1) and the blood circuit priming (S2) are the same as those in the first embodiment, and thus the description thereof is omitted. As shown in FIG. 10, S3 is a process for starting a circulation cleaning process for circulating the priming liquid in the blood circuit by driving the blood pump 4 to rotate forward.

  In such a circulation washing step, as shown in the figure, the clamp means (Vc, Vd) on the blood circuit side are closed and the clamp means (Va, Vb) are opened, and the electromagnet on the dialyzer main body B side is opened. The valves (V3, V4) are closed and the solenoid valves (V1, V2, V5 to V7) are opened. Then, the double pump 7 is driven while the blood pump 4 is driven to rotate forward, whereby the dialysate flows (gas purge) in the dialysate flow path in the dialyzer 1 while circulating the priming liquid in the blood circuit.

  In the circulation cleaning step, as in the first embodiment, the electromagnetic valve V7 of the air release line L7 and the electromagnetic valve V5 of the bypass line L6 are opened while allowing the dialysate to flow through the dialysate flow path in the dialyzer 1. Thus, negative pressure is applied to the blood circuit via the dialysate flow path, and the process proceeds to S4 and S5 to determine whether or not bubbles are detected by the bubble detection sensors (16a and 16b). A circuit connection confirmation step is performed. That is, since the blood circuit is set to a negative pressure, if there is a connection failure at any location in the blood circuit, air is sucked in from the connection failure portion, so that bubbles are generated, so the connection confirmation step (S4, S5 ), The presence or absence of poor connection can be confirmed by monitoring the bubbles with the bubble detection sensors (16a, 16b).

  In the present embodiment, it is determined in S4 that either the bubble detection sensor 16a or the bubble detection sensor 16b has detected a bubble, and the bubble detection sensor 16b has detected the bubble prior to the bubble detection sensor bubble 16a. Then, it progresses to S6 and the alarm for making the circumference | surroundings grasp connection failure is generated. Such an alarm displays a warning on a liquid crystal monitor or the like of the dialyzer main body B, generates a warning sound from a speaker attached to the dialyzer main body B, and lights or blinks a warning light extending upward from the dialyzer main body B Any form may be used.

  Here, in the present embodiment, after the alarm is given in S6, the process proceeds to S7, where the poor connection is at a position downstream from the bubble detection sensor 16a (position upstream from the bubble detection sensor 16b). Is identified. That is, since the blood pump 4 is driven to rotate in the forward direction, if there is a connection failure at that position, the bubbles sucked from the connection failure location are detected by the bubble detection sensor 16b and then the bubble detection sensor 16a. Since it will be detected, a connection failure location can be specified according to the detection order.

  On the other hand, if it is determined in S4 that no bubbles are detected, the process proceeds to S5. If it is determined in S5 that either the bubble detection sensor 16a or the bubble detection sensor 16b detects the bubble and the bubble detection sensor 16a detects the bubble before the bubble detection sensor bubble 16b, the process proceeds to S8. , Generate an alarm to let the surroundings know the connection failure. Such an alarm displays a warning on a liquid crystal monitor or the like of the dialyzer main body B, generates a warning sound from a speaker attached to the dialyzer main body B, and lights or blinks a warning light extending upward from the dialyzer main body B Any form may be used.

  Here, in the present embodiment, after the alarm is given in S8, the process proceeds to S9, and the connection failure is at a position downstream of the bubble detection sensor 16b (position upstream of the bubble detection sensor 16a). Is identified. That is, since the blood pump 4 is driven to rotate in the forward direction, if there is a connection failure at that position, the bubbles sucked from the connection failure location are detected by the bubble detection sensor 16a and then detected by the bubble detection sensor 16b. Since it will be detected, a connection failure location can be specified according to the detection order.

  If it is determined in S5 that no bubbles are detected, or if a connection failure is specified in S7 and S9, the process proceeds to S10 and an in-circuit cleaning process is performed. Since this in-circuit cleaning step S10 is the same as that in the first embodiment (see FIG. 7), description thereof is omitted. This completes a series of controls including priming.

  According to the present embodiment, as in the first embodiment, on the condition that the priming liquid is filled in the blood circuit, a negative pressure is applied to the blood circuit, and the bubble detection sensors (16a, 16b) Since it is determined whether or not bubbles are detected by the (bubble detection means) and the blood circuit connection confirmation process is performed, the connection confirmation process for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy. Can be done. The bubble detection sensor 16 detects bubbles when the blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned to the patient from the blood circuit after the blood purification treatment and returned to the patient. Since the blood return can be stopped or terminated, the function of preventing air bubbles from entering the patient and the function of confirming the connection can be combined.

  In particular, according to this embodiment, a plurality of bubble detection sensors (16a, 16b) are arranged in the blood circuit and can detect bubbles at a plurality of locations, and the bubble detection sensors (16a, 16b) in which bubbles are detected. ) Can be identified in accordance with (), so that it is possible to more quickly and smoothly take action after the connection failure is confirmed. In the present embodiment, the bubble detection sensors (16a, 16b) are disposed at the distal end portion of the arterial blood circuit 2 and the distal end portion of the venous blood circuit 3, respectively. It is good also as what can arrange | position the bubble detection sensor of this and can identify a connection failure location according to the bubble detection sensor from which the bubble was detected.

Next, a blood purification apparatus according to the third embodiment of the present invention will be described.
As in the first embodiment, the blood purification apparatus according to this embodiment is applied to a hemodialysis apparatus. As shown in FIG. 1, an arterial blood circuit 2 and a dialyzer 1 as blood purification means are provided. A blood circuit to which the venous blood circuit 3 is connected, a dialyzer body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming fluid supply line La, and a bubble detection sensor 16 as a bubble detection means; The control unit 17 is mainly configured. That is, the device configuration is the same as that of the first embodiment.

Hereinafter, the control contents of the control means 17 according to the present embodiment will be described based on the flowchart of FIG. 11 and FIGS.
First, before dialysis treatment (before priming), as shown in FIG. 1, by connecting the connector a and the connector b, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are connected, A closed circuit on the blood circuit side is formed by the arterial blood circuit 2 and the venous blood circuit 3 (including a flow path through which blood in the dialyzer 1 flows).

  Thereafter, after confirmation of connection of the blood circuit by pressurization (S1) and priming of the blood circuit (S2), the operation proceeds to S3 to perform an operation of applying a negative pressure in the blood circuit. Note that the blood circuit connection confirmation (S1) and the blood circuit priming (S2) are the same as those in the first embodiment, and thus the description thereof is omitted. In S3, as shown in FIG. 12, a negative pressure is applied to the blood circuit by driving the blood pump 4 in a reverse rotation while closing a predetermined position of the blood circuit (in this embodiment, the position of the clamp means Va). Configured to get.

  Specifically, as shown in the figure, the clamping means (Va, Vc, Vd) on the blood circuit side are closed and the clamping means Vb are opened, and the solenoid valve (V1, V2, V4, V7) are closed and the solenoid valves (V3, V5, V6) are opened. Then, the negative pressure is formed in the blood circuit by driving the compound pump 7 while the blood pump 4 is driven to rotate in the reverse direction. Therefore, since the blood circuit is set to a negative pressure, if there is a connection failure at any location in the blood circuit, air is sucked from the connection failure portion to generate bubbles.

  Thereafter, the process proceeds to S4 and the priming solution is circulated in the blood circuit. S4, as shown in FIG. 13, the clamp means (Vc, Vd) on the blood circuit side are closed and the clamp means (Va, Vb) are opened, and the solenoid valves (V1, Vd) on the dialyzer main body B side are opened. V2, V4, V7) are closed and the solenoid valves (V3, V5, V6) are opened. The priming liquid is circulated in the blood circuit by driving the compound pump 7 while driving the blood pump 4 to rotate forward.

  After S4, the process proceeds to S5, where a blood circuit connection confirmation step is performed to determine whether or not bubbles are detected by the bubble detection sensor 16. That is, if there is a connection failure at any location in the blood circuit, air is sucked from the connection failure site in S3, and bubbles are generated. Therefore, the bubbles are monitored by the bubble detection sensor 16 through the connection confirmation step S5. As a result, the presence or absence of a connection failure can be confirmed.

  And when it determines with the bubble being detected in S5, it progresses to S6 and the alarm for making a periphery grasp | ascertain a connection failure is generated. Such an alarm displays a warning on a liquid crystal monitor or the like of the dialyzer main body B, generates a warning sound from a speaker attached to the dialyzer main body B, and lights or blinks a warning light extending upward from the dialyzer main body B Any form may be used.

  After it is determined in S5 that bubbles are not detected or an alarm is generated in S6, the circulation cleaning S7 and the in-circuit cleaning S8 are continued. Since these circulation cleaning S7 (see FIG. 6) and in-circuit cleaning S8 (see FIG. 7) are the same as those in the first embodiment, the description thereof will be omitted. This completes a series of controls including priming.

  According to the present embodiment, on the condition that the priming liquid is filled in the blood circuit, a negative pressure is applied to the blood circuit, and bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since the blood circuit connection confirmation process is performed by determining whether or not the blood circuit is connected, the connection confirmation process for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy. The bubble detection sensor 16 detects bubbles when the blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned to the patient from the blood circuit after the blood purification treatment and returned to the patient. Since the blood return can be stopped or terminated, the function of preventing air bubbles from entering the patient and the function of confirming the connection can be combined.

  In particular, according to the present embodiment, the blood pump 4 disposed in the arterial blood circuit 2 is driven while the clamp means Va is closed to close a predetermined position of the blood circuit (position of the clamp means Va) ( Since the negative pressure can be applied to the blood circuit by performing reverse rotation driving), the connection confirmation step can be easily performed during or after the priming of the blood circuit.

Next, a blood purification apparatus according to the fourth embodiment of the present invention will be described.
As in the first embodiment, the blood purification apparatus according to this embodiment is applied to a hemodialysis apparatus. As shown in FIGS. 15 to 20, an arterial blood circuit is added to the dialyzer 1 as blood purification means. 2, a blood circuit to which the venous blood circuit 3 is connected, a dialyzer body B having a dialysate introduction line L1 and a dialysate discharge line L2, a priming fluid supply line La, and a bubble detection sensor as a bubble detection means 16, the control means 17, and the liquid level adjustment means (18, 19). In addition, the same code | symbol is attached | subjected to the component same as 1st Embodiment, and those description is abbreviate | omitted.

  The liquid level adjusting means (18, 19) includes extended tubes (18a, 19a) extending from the upper part (air layer) of the artery-side air trap chamber 5 and having their tips opened to the atmosphere, and these extended tubes (18a). , 19b) and liquid level adjustment pumps (18b, 19b). The liquid level adjusting pumps (18b, 19b) are ironing type pumps that can be driven forward and backward, and by squeezing the extending tubes (18a, 19a) in the longitudinal direction thereof, the arterial air Air is introduced into or discharged from the upper part of the trap chamber 5 or the upper part of the venous air trap chamber 6.

  Thus, when the liquid level adjusting pump (18b, 19b) is driven to rotate in the forward direction, air is sucked from the distal end of the extension tube (18a, 19b), so that the artery side air trap chamber 5 and the vein side air trap chamber 6 are sucked. When the liquid level adjustment pump (18b, 19b) is driven in reverse rotation, air is discharged from the tip of the extension tube (18a, 19a) Air can be discharged from the arterial air trap chamber 5 and the venous air trap chamber 6 to raise the liquid level.

Hereinafter, the control contents of the control means 17 according to the present embodiment will be described based on the flowchart of FIG. 14 and FIGS.
First, before dialysis treatment (before priming), as shown in FIG. 15, the tip of the arterial blood circuit 2 and the tip of the venous blood circuit 3 are left open, and the blood circuit is pressurized. Confirm connection of blood circuit (S1). In this S1, as shown in the figure, the clamp means (Vb, Vc) on the blood circuit side are closed and the clamp means Va are opened, and the solenoid valves (V1 to V7) on the dialyzer body B side. Is closed.

  Then, each of the liquid level adjusting pumps (18b, 19b) is driven to rotate forward, and air is introduced into the arterial air trap chamber 5 and the venous air trap chamber 6 from the distal ends of the extending tubes (18a, 19b). Pressurize the blood circuit. The blood pump 4 and the duplex pump 7 are in a stopped state. After the liquid level adjusting pumps (18b, 19b) are driven to rotate forward for the set flow rate or time, the liquid level adjusting pumps (18b, 19b) are stopped and the fluid pressure in the blood circuit is adjusted by the venous pressure sensor 13. If it is detected and the detected value does not exceed a predetermined threshold value, it is determined that there is an unconnected part and is notified. Further, even when the fluid pressure detected by the venous pressure sensor 13 exceeds a predetermined threshold, if the detected value is not held for a predetermined time (for example, 2 seconds), it is determined that there is an unconnected portion and a notification is made. To do.

  After confirming the connection of the blood circuit by pressurization of S1, the process proceeds to S2, and the priming liquid (dialysis liquid) is filled in the priming liquid supply line La. In S2, as shown in FIG. 16, the clamp means (Va to Vc) on the blood circuit side are opened, and the solenoid valves (V1 to V4, V7) on the dialyzer main body B side are closed and electromagnetic. Open the valves (V5, V6). Then, by driving the dual pump 7 while stopping the blood pump 4, the priming fluid (dialysate) is filled to the tip of the priming fluid supply line La and the arterial blood circuit 2.

  After the compound pump 7 is driven for a predetermined time, the process proceeds to S3, where the entire blood circuit is filled with a priming solution (dialysis solution) for priming. In S3, as shown in FIG. 17, the clamp means Va on the blood circuit side is closed and the clamp means (Vb, Vc) are opened, and the solenoid valves (V1, V2,. V4, V7) are closed and the solenoid valves (V3, V5, V6) are opened. Then, the priming solution (dialysis solution) is filled in the entire blood circuit by driving the compound pump 7 while driving the blood pump 4 to rotate forward. Thereafter, the liquid level adjusting pumps 18 and 19 are appropriately driven to discharge the air in the arterial air trap chamber 5 and the venous air trap chamber 6 to fill the priming liquid, and the arterial air trap chamber 5 and A liquid level is formed in the venous air trap chamber 6.

  After the flow rate of the blood pump 4 reaches a predetermined amount, the process proceeds to S4, and a gas purge is performed to fill the dialysate flow path of the dialyzer 1 with the dialysate flowing. In S4, as shown in FIG. 18, the clamp means (Va, Vb) on the blood circuit side are closed and the clamp means Vc are opened, and the solenoid valves (V3, V4, V7) is closed and the solenoid valves (V1, V2, V5, V6) are opened. Then, the dialysis fluid flows and fills the dialysis fluid flow path of the dialyzer 1 by driving the compound pump 7 while driving the blood pump 4 to rotate forward.

  After the compound pump 7 is driven for a predetermined time, the process proceeds to S5 to apply a negative pressure to the blood circuit. In S5, as shown in FIG. 19, the clamp means (Va to Vc) on the blood circuit side are closed, and the solenoid valves (V3, V4) on the dialyzer body B side are closed and the solenoid valves ( V1, V2, V5, V6, V7) are opened. That is, in S5, the electromagnetic valve V7 of the atmosphere release line L7 and the electromagnetic valve V5 of the bypass line L6 are opened while flowing the dialysate into the dialysate flow path in the dialyzer 1. Thus, negative pressure is applied to the blood circuit.

  Then, it progresses to S6 and circulates a priming liquid in the blood circuit. In S6, as shown in FIG. 20, the clamp means Va on the blood circuit side is closed and the clamp means (Vb, Vc) are opened, and the electromagnetic valves (V1, V2,. V4, V7) are closed and the solenoid valves (V3, V5, V6) are opened. In this state, the process proceeds to S7, where a blood circuit connection confirmation step is performed to determine whether or not bubbles are detected by the bubble detection sensor 16. That is, since the blood circuit is set to a negative pressure in S5, if there is a connection failure at any location in the blood circuit, air is sucked from the connection failure portion and bubbles are generated. The presence or absence of poor connection can be confirmed by monitoring the bubbles with the bubble detection sensor 16 after passing through the above.

  And when it determines with the bubble being detected in S7, it progresses to S8 and the alarm for making a periphery grasp | ascertain a connection failure is generated. Such an alarm displays a warning on a liquid crystal monitor or the like of the dialyzer main body B, generates a warning sound from a speaker attached to the dialyzer main body B, and lights or blinks a warning light extending upward from the dialyzer main body B Any form may be used. Thus, after it is determined in S7 that bubbles are not detected or an alarm is generated in S8, a series of control including priming is completed.

  According to the present embodiment, on the condition that the priming liquid is filled in the blood circuit, a negative pressure is applied to the blood circuit, and bubbles are detected by the bubble detection sensor 16 (bubble detection means). Since the blood circuit connection confirmation process is performed by determining whether or not the blood circuit is connected, the connection confirmation process for confirming the quality of the blood circuit connection can be performed in a shorter time and with higher accuracy. The bubble detection sensor 16 detects bubbles when the blood is circulated extracorporeally in the blood circuit during blood purification treatment, or when blood is returned to the patient from the blood circuit after the blood purification treatment and returned to the patient. Since the blood return can be stopped or terminated, the function of preventing air bubbles from entering the patient and the function of confirming the connection can be combined.

  In addition, a negative pressure can be applied to the blood circuit by making the negative pressure while allowing the dialysate to flow in the dialysate flow path formed in the dialyzer 1 (blood purification means). The connection confirmation step can be performed by utilizing a phenomenon in which a negative pressure is generated during the gas purge step of filling the liquid. That is, in the gas purging process, in order to prevent the dual pump 7 from sucking bubbles discharged from the dialysate flow path in the dialyzer 1, the bubbles are captured in the degassing chamber 15 and the electromagnetic valve V7 is set. It is configured to discharge air bubbles to the outside from the air release line L7 in the open state, and at that time, a phenomenon occurs in which a negative pressure is applied to the blood circuit via the dialysate flow path. According to this embodiment, this phenomenon can be used to apply a negative pressure to the blood circuit during the connection confirmation process.

  Although the present embodiment has been described above, the present invention is not limited to these. For example, without confirming the connection of the blood circuit by pressurization, the bubble detection sensor 16 applies a negative pressure to the blood circuit. It is good also as what detects a bubble. In the connection confirmation step, means for applying a negative pressure to the blood circuit is not limited to the above embodiment, and various means can be used. The priming solution is not limited to using a dialysis solution as in the above embodiment, and may be, for example, a physiological saline solution or other liquid contained in a saline bag.

  Furthermore, the bubble detection sensor 16 (bubble detection means) that can detect bubbles in the connection confirmation step may be disposed in any part of the blood circuit. For example, the connection part with the dialyzer 1 in the arterial blood circuit 2 It is good also as what is arrange | positioned in the vicinity (inlet part to the dialyzer 1) or the connection site | part vicinity (the exit part from a dialyzer) with the dialyzer 1 in the venous side blood circuit 3, and confirming the connection of the dialyzer 1 reliably.

  Blood that allows a negative pressure to be applied to the blood circuit on the condition that the blood circuit is filled with a priming solution, and whether or not bubbles are detected by the bubble detection means to perform a connection confirmation step If it is a purification apparatus and its connection confirmation method, it can apply also to what added the other function.

1 ... Dializer (blood purification means)
DESCRIPTION OF SYMBOLS 2 ... Arterial side blood circuit 3 ... Vein side blood circuit 4 ... Blood pump 5 ... Arterial side air trap chamber 6 ... Vein side air trap chamber 7 ... Duplex pump 8, 9 ... Filtration filter 10 ... Dewatering pump 11 ... Collection port 12 ... Hydraulic pressure measurement sensor 13 ... Venous pressure sensor 14 ... Pressure pump 15 ... Degassing chamber 16 ... Bubble detection sensor (bubble detection means)
DESCRIPTION OF SYMBOLS 17 ... Control means 18, 19 ... Liquid level adjustment means L1 ... Dialysate introduction line L2 ... Dialysate discharge line L7 ... Air release line La ... Priming liquid supply line Lb Overflow line B ... Dialyzer main body a, b ... Connector

Claims (10)

A blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating the patient's blood;
Blood purification means connected between the arterial blood circuit and the venous blood circuit and purifying blood flowing through the blood circuit;
Bubble detecting means capable of detecting bubbles in the liquid flowing in the blood circuit;
A control means capable of supplying a priming solution to the blood circuit to perform priming of the blood circuit, and capable of performing a connection confirmation step for confirming whether the blood circuit is connected or not;
In the blood purification apparatus comprising
The control means applies a negative pressure to the blood circuit on the condition that the blood circuit is filled with a priming solution, and determines whether or not bubbles are detected by the bubble detection means. A blood purification apparatus capable of performing the connection confirmation step.   A plurality of the bubble detection means may be disposed in the blood circuit to detect bubbles at a plurality of locations, and the control means may identify a poorly connected location according to the bubble detection means in which bubbles are detected. The blood purification apparatus according to claim 1.   The said control means can give the said negative pressure in the said blood circuit by making it a negative pressure, making a dialysate flow in the dialysate flow path formed in the said blood purification means. The blood purification apparatus according to claim 1 or 2.   The control means can apply the negative pressure in the blood circuit by driving a blood pump disposed in the artery-side blood circuit while closing a predetermined position of the blood circuit. The blood purification apparatus according to claim 1 or 2.   The control means may sequentially perform a priming solution filling step for filling the blood circuit with a priming solution and a circulation washing step for circulating the priming solution filled in the priming solution filling step in the blood circuit. In addition, the blood purification apparatus according to any one of claims 1 to 4, wherein the connection confirmation step is performed during the circulation cleaning step. A blood circuit having an arterial blood circuit and a venous blood circuit capable of extracorporeally circulating the patient's blood;
Blood purification means connected between the arterial blood circuit and the venous blood circuit and purifying blood flowing through the blood circuit;
Bubble detecting means capable of detecting bubbles in the liquid flowing in the blood circuit;
A control means capable of supplying a priming solution to the blood circuit to perform priming of the blood circuit, and capable of performing a connection confirmation step for confirming whether the blood circuit is connected or not;
In the method for confirming the connection of the blood purification apparatus comprising:
On the condition that the blood circuit is filled with a priming solution, a negative pressure is applied to the blood circuit, and it is determined whether or not air bubbles are detected by the air bubble detecting means to confirm connection of the blood circuit. A method for confirming the connection of a blood purification apparatus, comprising performing a step.   A plurality of the bubble detection means are arranged in the blood circuit and can detect bubbles at a plurality of locations, and can identify a poor connection location according to the bubble detection means in which bubbles are detected. Item 7. A blood purification apparatus connection confirmation method according to Item 6.   8. The negative pressure can be applied to the blood circuit by applying a negative pressure while flowing a dialysate into a dialysate flow path formed in the blood purification means. The blood purification apparatus connection confirmation method described.   7. The negative pressure can be applied to the blood circuit by driving a blood pump disposed in the arterial blood circuit while closing a predetermined position of the blood circuit. 8. The method for confirming connection of the blood purification apparatus according to 7.   A priming solution filling step for filling the blood circuit with a priming solution, and a circulation washing step for circulating the priming solution filled in the priming solution filling step in the blood circuit can be sequentially performed. The connection confirmation method for a blood purification apparatus according to any one of claims 6 to 9, wherein the connection confirmation step is performed during the process.

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