CN108136100B - Blood purification device - Google Patents
Blood purification device Download PDFInfo
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- CN108136100B CN108136100B CN201680060936.0A CN201680060936A CN108136100B CN 108136100 B CN108136100 B CN 108136100B CN 201680060936 A CN201680060936 A CN 201680060936A CN 108136100 B CN108136100 B CN 108136100B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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Abstract
The present invention addresses the problem of providing a blood purification apparatus that can reliably fill the blood channel and the dialysate channel of the blood purification means with priming liquid and that does not require the medical staff to reverse the blood purification means at the start of the blood purification treatment. When filling the priming solution, the dialyzer (2) is held with the blood outlet port (2b) facing upward, the priming solution introduced into the blood channel (2e) of the dialyzer (2) from the blood inlet port (2a) is filtered to the dialysate channel (21) via the blood purification membrane (2g), and the priming solution is extracted from the dialysate inlet port (2c) to prime the dialysate channel (2 f).
Description
Technical Field
The present invention relates to a blood purification apparatus for purifying blood of a patient while extracorporeally circulating the blood.
Background
In general, a blood purification apparatus for performing dialysis treatment includes an arterial-side blood circuit and a venous-side blood circuit constituting a blood circuit for extracorporeally circulating blood of a patient; blood purification means for purifying blood extracorporeally circulated through the blood circuit; the blood purification treatment apparatus includes an apparatus main body in which various treatment mechanisms such as a blood pump for performing blood purification treatment using a blood circuit and a blood purifier are provided. A blood vessel contact probe or a puncture needle (an arterial puncture needle and a venous puncture needle) may be attached to the tip of each of the arterial blood circuit and the venous blood circuit.
In addition, for example, after the arterial needle and the venous needle are inserted into the patient, the blood pump is driven to flow the blood of the patient through the arterial blood circuit and the venous blood circuit, and the blood is purified by the blood purification means during the flow. In the dialysis treatment, a dialysate introduction line for introducing dialysate into the blood purification means and a dialysate discharge line for discharging a drain from the blood purification means are connected to the blood purification means, respectively.
In such a blood purification apparatus, it is necessary to prime the blood circuit and the blood purification means before the blood purification treatment. This priming is usually performed by driving a blood pump to supply physiological saline to a blood circuit, and is performed by: the priming solution is filled in a channel through which blood in the blood circuit is extracorporeally circulated, a channel through which blood flows in the blood purification means (blood channel), and a channel through which dialysate flows (dialysate channel). The prior art does not relate to the invention known in the literature, and therefore there is no information on the prior art to be described.
Disclosure of Invention
Problems to be solved by the invention
The conventional blood purification apparatus described above has the following problems.
For reasons of dialysis efficiency, the blood purification means is set so that the direction of flow of the dialysate in the dialysate channel faces the direction of flow of the blood in the blood channel. Further, when air bubbles remaining in the arterial blood circuit enter the blood purification means before the blood purification treatment, the air bubbles are directed upward and easily pass through the blood purification means, and therefore the blood purification treatment is performed while holding the blood purification means with the outlet (blood lead-out port) of the blood channel directed upward.
On the other hand, when the blood outlet port is directed upward as described above, the dialysate outlet port (dialysate outlet port) is positioned below the dialysate inlet port (dialysate inlet port), and it is difficult to satisfactorily discharge air bubbles remaining in the dialysate flow path during priming. This requires that the blood outlet port is directed downward during priming, and that the blood purification mechanism be inverted upward and the blood outlet port be directed upward when blood purification treatment is started, which requires the medical staff to perform the inversion operation.
The present invention has been made in view of the above circumstances, and provides a blood purification apparatus that can reliably fill the blood flow path and the dialysate flow path of the blood purification means with priming liquid and does not require the reversal operation of the blood purification means by the medical staff at the start of the blood purification treatment.
Means for solving the problems
A first aspect of the present invention relates to a blood purification apparatus including:
blood purification mechanism, this blood purification mechanism includes: a blood introduction port through which blood can be introduced; a blood lead-out port through which blood can be led out; a blood channel extending in the range of the blood introduction port and the blood discharge port and allowing blood to flow therethrough; a dialysate introduction port into which dialysate can be introduced; a dialysate extraction port from which dialysate can be extracted; a dialysate flow path extending in the range of the dialysate introduction port and the dialysate extraction port and allowing dialysate to flow in a direction facing the blood flowing through the blood flow path; a blood purification membrane that is interposed between the blood channel and the dialysate channel and that can purify blood flowing through the blood channel;
a blood circuit including an arterial blood circuit connected to the blood introduction port of the blood purification means and a venous blood circuit connected to the blood discharge port, the blood circuit being capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;
a dialysate introduction line connected to a dialysate introduction port of the blood purification means and capable of introducing dialysate into the blood purification means; a dialysate discharge line connected to the dialysate discharge port of the blood purification mechanism for discharging the discharged fluid from the blood purification mechanism;
a blood pump provided in the arterial blood circuit and configured to extracorporeally circulate blood of the patient from the arterial blood circuit to the venous blood circuit and to drive the blood pump to supply priming liquid to the blood circuit for priming,
the blood purification apparatus is characterized in that the blood purification means is held in a state in which the blood lead-out port is directed upward during filling of the priming solution for priming, the priming solution introduced into the blood channel of the blood purification means from the blood lead-in port is filtered into the dialysate channel through the blood purification membrane, and is led out from the dialysate lead-in port to prime the dialysate channel, and the blood purification apparatus further comprises a fluid replacement line capable of communicating a predetermined portion of the arterial blood circuit with the dialysate lead-in line, and capable of discharging gas discharged from the dialysate lead-in port of the blood purification means into the venous blood circuit through the fluid replacement line during filling of the priming solution for priming.
A second aspect of the present invention is the blood purification apparatus according to the first aspect, wherein a priming solution receiving bag that receives a priming solution is connectable to at least a distal end portion of the arterial blood circuit and the venous blood circuit, and the priming solution in the priming solution receiving bag is supplied to the blood circuit at the time of filling the priming solution.
A third aspect of the present invention is directed to the blood purification apparatus according to the first aspect, including a substitution pump that is provided on the substitution line and is capable of delivering dialysate from the dialysate introduction line to the venous blood circuit, wherein, at the time of filling the priming solution, a flow rate of the substitution pump is set to be equal to or less than a flow rate of the blood pump, and gas discharged from a dialysate introduction port of the blood purification means is capable of being discharged to the venous blood circuit via the substitution line.
A fourth aspect of the present invention is a blood purification apparatus according to the first aspect, including an opening/closing mechanism that is provided between the blood purification mechanism of the venous blood circuit and a connection portion of the fluid replacement line, and that is capable of opening and closing the flow path as desired, and that is capable of closing the flow path by closing the opening/closing mechanism at the time of filling the priming fluid, thereby discharging gas discharged from a dialysate introduction port of the blood purification mechanism into the venous blood circuit via the fluid replacement line.
A fifth aspect of the present invention is the blood purification apparatus according to the first, third, or fourth aspect, wherein the gas discharged into the venous blood circuit can be recovered by a recovery vessel connected to a distal end portion of the venous blood circuit at the time of filling the priming liquid.
A sixth aspect of the present invention is directed to the blood purification apparatus according to the first, third or fourth aspect, characterized in that it comprises: a blood circuit-side air trap chamber provided at a connection portion of the fluid replacement line of the vein-side blood circuit;
an air discharge line extending from an upper portion of the blood circuit side air trap chamber and capable of discharging air in the blood circuit side air trap chamber;
an air discharge mechanism capable of discharging the air in the blood circuit-side air capturing chamber to the outside through the air discharge line;
the blood circuit side air trap chamber may trap gas discharged into the venous side blood circuit during filling of the priming solution, and the air discharge mechanism may be operated to discharge the gas to the outside through the air discharge line.
A seventh aspect of the present invention is directed to the blood purification apparatus according to the sixth aspect, including liquid surface detection means for detecting a liquid surface in the blood circuit-side air trapping chamber and stopping the discharge of the gas by the air discharge means on condition that the liquid surface detection means detects a liquid surface at a predetermined height.
An eighth aspect of the present invention relates to the blood purification apparatus according to the first aspect, including:
a dialysate receiving bag connected to a distal end portion of the dialysate introduction line, the dialysate receiving bag receiving dialysate introduced into the blood purification mechanism;
a drain receiving bag connected to a distal end portion of the dialysate discharge line and configured to receive drain discharged from the blood purification unit;
a dialysate pump that is provided on the dialysate introduction line and that delivers the dialysate of the dialysate receiving bag to the blood purification mechanism;
and a drain pump provided on the dialysate discharge line and configured to transport the drain discharged from the blood purification mechanism to the drain receiving bag.
A ninth aspect of the present invention is directed to the blood purification apparatus according to the eighth aspect, wherein the dialysate pump is driven in reverse so that a flow rate of the dialysate pump becomes equal to or less than a flow rate of the blood pump at the time of filling the priming solution, so that the priming solution introduced into the blood channel of the blood purification mechanism from the blood introduction port is filtered into the dialysate channel through the blood purification membrane, and is led out from the dialysate introduction port to prime the dialysate channel.
A tenth aspect of the present invention relates to the blood purification apparatus according to the eighth or ninth aspect, comprising: a dialysate side air trap chamber provided between the dialysate pump of the dialysate introduction line and the blood purification mechanism; an air discharge line extending from an upper portion of the dialysate side air capture chamber and configured to discharge air in the dialysate side air capture chamber; an air discharge mechanism capable of discharging air in the dialysate side air trap chamber to the outside via the air discharge line; the air discharge mechanism is operable to capture the gas discharged from the dialysate introduction port by the dialysate side air capture chamber during filling of the priming solution, and to discharge the gas to the outside through the air discharge line.
An eleventh aspect of the present invention is a blood purification apparatus according to the tenth aspect, comprising liquid surface detection means for detecting a liquid surface in the dialysate side air trap chamber and stopping the discharge of gas by the air discharge means on condition that the liquid surface detection means detects a liquid surface at a predetermined height.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the first aspect of the present invention, the blood purification mechanism can be held with the blood outlet port directed upward during filling of the priming solution that has been primed, and the priming solution introduced into the blood channel of the blood purification mechanism from the blood inlet port can be filtered into the dialysate channel via the blood purification membrane and then be withdrawn from the dialysate inlet port to prime the dialysate channel. Since the blood purification mechanism includes the fluid replacement line that can communicate the predetermined site of the venous blood circuit with the dialysate introduction line and can discharge the gas discharged from the dialysate introduction port of the blood purification mechanism to the venous blood circuit via the fluid replacement line at the time of filling the priming fluid, priming can be performed more efficiently.
According to the second aspect of the present invention, the priming solution receiving bag that receives the priming solution can be connected to at least the distal end portion of the arterial blood circuit and the venous blood circuit, and the priming solution in the priming solution receiving bag can be supplied to the blood leading circuit when the priming solution is filled, so that the filling of the priming solution on the blood circuit side can be performed more reliably and smoothly.
According to the third aspect of the present invention, since the fluid replacement pump is provided on the fluid replacement line and can deliver the dialysate from the dialysate introduction line to the vein blood circuit, and the flow rate of the fluid replacement pump is set to be equal to or lower than the flow rate of the blood pump at the time of filling the priming fluid, the gas discharged from the dialysate introduction port of the blood purification means can be discharged to the vein blood circuit via the fluid replacement line, and therefore the fluid replacement pump can be used, and more effective priming can be performed.
According to the fourth aspect of the present invention, the blood purification device is provided with an opening/closing mechanism which is provided between the blood purification device of the vein-side blood circuit and the connection part of the substitution line, and which can open and close the flow path as desired, and which can close the flow path by closing the opening/closing mechanism at the time of filling the priming solution, and which can discharge the gas discharged from the dialysate introduction port of the blood purification device into the vein-side blood circuit via the substitution line. Therefore, the gas can be discharged through the fluid replacement line more reliably, and more effective priming can be performed.
According to the fifth aspect of the present invention, since the gas discharged into the venous blood circuit can be recovered by the recovery vessel connected to the tip end portion of the venous blood circuit at the time of filling the priming liquid with the priming liquid, the gas replacing the priming liquid can be recovered more reliably at the time of filling the priming liquid.
According to the sixth aspect of the present invention, since the gas discharged into the venous blood circuit can be trapped by the blood circuit side air trapping chamber and the air discharge mechanism can be operated to discharge the gas to the outside via the air discharge line at the time of filling the priming solution, the blood circuit side air trapping chamber and the air discharge mechanism can be used, and the gas replacing the priming solution can be reliably discharged to the outside at the time of filling the priming solution.
According to the seventh aspect of the present invention, since the blood circuit side air trap chamber includes the liquid level detection means for detecting the liquid level of the blood circuit side air trap chamber and stopping the gas discharge by the air discharge means on the condition that the liquid level detection means detects the liquid level at a predetermined height, the liquid level detection means can be used to detect that the priming liquid is completely replaced with gas, and the priming operation of the priming liquid can be terminated, thereby enabling more efficient priming.
According to an eighth aspect of the present invention, there is provided a dialysate receiving bag connected to a distal end portion of the dialysate introduction line, the dialysate receiving bag receiving dialysate introduced into the blood purification means; a drain receiving bag connected to a distal end portion of the dialysate discharge line and configured to receive drain discharged from the blood purification unit; a dialysate pump that is provided on the dialysate introduction line and that delivers the dialysate of the dialysate receiving bag to the blood purification mechanism; and a drain pump provided on the dialysate discharge line and configured to transport the discharged liquid from the blood purification mechanism to the liquid discharge bag, so that the priming can be performed more efficiently by using the dialysate pump or the drain pump.
According to the ninth aspect of the present invention, when the priming solution is filled, the dialysate pump is driven in reverse so that the flow rate of the dialysate pump is equal to or less than the flow rate of the blood pump, whereby the priming solution introduced into the blood channel of the blood purification mechanism from the blood introduction port is filtered into the dialysate channel through the blood purification membrane, the priming solution is introduced from the dialysate introduction port, and the dialysate channel is primed, so that more effective priming can be performed by the cooperative action of the dialysate pump and the blood pump.
According to the tenth aspect of the present invention, the gas discharged from the dialysate introduction port can be captured by the dialysate side air capture chamber and the air discharge mechanism can be operated to discharge the gas to the outside through the air discharge line during filling of the priming solution, so that the dialysate side air capture chamber and the air discharge mechanism can be used, and the gas replacing the priming solution can be reliably discharged to the outside during filling of the priming solution.
According to the eleventh aspect of the present invention, since the liquid level detection means is provided for detecting the liquid level in the dialysate side air trap chamber and the gas discharge from the air discharge means is stopped on condition that the liquid level at a predetermined height is detected by the liquid level detection means, the liquid level detection means can be used to detect that the priming liquid is completely replaced with gas, and the priming operation can be terminated, thereby enabling more efficient priming.
Drawings
FIG. 1 is a schematic view showing a blood purification apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic view showing a blood purification mechanism used in the blood purification apparatus;
FIG. 3 is a flowchart showing steps performed during priming of the blood purification apparatus;
FIG. 4 is a schematic view showing the blood purification apparatus (at the time of filling the priming solution);
FIG. 5 is a schematic view showing the blood purification apparatus (at the time of filling the priming solution);
FIG. 6 is a schematic view showing the blood purification apparatus (at the time of filling the priming solution);
FIG. 7 is a schematic view showing the blood purification apparatus (at the time of filling the priming solution);
FIG. 8 is a schematic view showing a blood purification apparatus (of the type having an opening/closing mechanism);
fig. 9 is a schematic diagram showing a blood purification apparatus according to another embodiment of the present invention.
Detailed Description
Embodiments of the present invention will be specifically described below with reference to the accompanying drawings.
The blood purification apparatus of the present embodiment is applied to a blood purification apparatus for purifying blood of a patient while extracorporeally circulating the blood, and includes, as shown in fig. 1: a blood circuit 1, the blood circuit 1 having an arterial blood circuit 1a and a venous blood circuit 1 b; a dialyzer (blood purification means) 2 interposed between the arterial blood circuit 1a and the venous blood circuit 1b, the dialyzer 2 purifying blood flowing through the blood circuit 1; a blood pump P1, the blood pump P1 being constituted by a peristaltic pump provided in the arterial blood circuit 1 a; a dialysate introduction line L1 and a dialysate discharge line L2; a dialysate pump P2 and a drain pump P3 respectively provided in the dialysate introduction line L1 and the dialysate discharge line L2; a fluid replacement line L3; the fluid replacement pump P4, the fluid replacement pump P4 is arranged on the fluid replacement pipeline L3; and a control mechanism 11. In the figure, symbol P denotes a pressure detection mechanism.
The arterial blood circuit 1a and the venous blood circuit 1b are connected at their distal ends with connectors, and an arterial puncture needle and a venous puncture needle (not shown) are connectable via the connectors. Further, if the blood pump P1 is rotationally driven (normally rotated) in a state where the patient is punctured by the artery side puncture needle connected to the tip of the artery side blood circuit 1a and the vein side puncture needle connected to the tip of the vein side blood circuit 1b, the blood of the patient passes through the artery side blood circuit 1a to reach the dialyzer 2, is blood-purified by the dialyzer 2, and then passes through the vein side blood circuit 1b to return to the body of the patient. In addition, instead of the method of puncturing the patient with the arterial puncture needle and the venous puncture needle, a double hollow lumen probe may be inserted into the subclavian vein or the femoral vein of the patient, or into the blood vessel of the arm of the patient.
Further, a blood circuit side air trap chamber 3 is connected to a middle portion of the vein side blood circuit 1b, and the extracorporeally circulated blood is returned to the patient after bubbles are removed by the air trap chamber 3. Further, a clamping mechanism 5 is provided at the distal end of the venous blood circuit 1b, and the channel at that position can be opened or closed by arbitrarily opening or closing the clamping mechanism 5.
In the venous blood circuit 1b of the present embodiment, a blood circuit side air trap chamber 3 is formed, and the blood circuit side air trap chamber 3 is provided at the connection part of the fluid replacement line L3; an air discharge line La extending from an upper portion of the blood circuit side air trap chamber 3 and capable of discharging air in the blood circuit side air trap chamber 3; an air discharge mechanism 9, the air discharge mechanism 9 being capable of discharging air inside the blood circuit side air capturing chamber 3 to the outside via an air discharge line La, and in the blood circuit side air capturing chamber 3, a liquid level detection mechanism 6 is mounted, the liquid level detection mechanism 6 being capable of detecting the liquid level of the blood circuit side air capturing chamber 3.
The air discharge mechanism 9 includes a flow path communicating with the air discharge line La, the front end of the flow path is opened to the atmosphere via a filter, and an electromagnetic valve Va and a squeeze pump Pa are attached to the flow path. The structure is as follows: by driving the squeeze pump Pa in the forward direction to discharge the air in the blood circuit side air trapping chamber 3 to the outside by opening the electromagnetic valve Va, the liquid level in the blood circuit side air trapping chamber 3 can be raised, and by driving the squeeze pump Pa in the reverse direction, the air can be introduced into the blood circuit side air trapping chamber 3 to lower the liquid level in the blood circuit side air trapping chamber 3.
The dialyzer 2, as shown in fig. 2, includes a blood introduction port 2a into which blood can be introduced; a blood outlet port 2b through which blood can be discharged; a blood channel 2e extending in the range of the blood inlet port 2a and the blood outlet port 2b and allowing blood to flow through the blood channel 2 e; a dialysate introduction port 2c into which dialysate can be introduced; a dialysate outlet port 2d from which dialysate can be led out; a dialysate channel 2f extending in the range of the dialysate introduction port 2c and the dialysate extraction port 2d, the dialysate channel 2f being configured to allow the dialysate to flow in a direction facing the blood flowing through the blood channel 2 e; and a blood purification membrane 2g interposed between the blood channel 2e and the dialysate channel 2f, the blood purification membrane 2g being capable of purifying blood flowing through the blood channel 2 e.
More specifically, the dialyzer 2 has a blood inlet port 2a, a blood outlet port 2b, a dialysate inlet port 2c, and a dialysate inlet port 2d formed so as to protrude from the housing, and among these, the blood inlet port 2a is connected to the arterial blood circuit 1a, the blood outlet port 2b is connected to the venous blood circuit 1b, the dialysate inlet port 2c is connected to the dialysate inlet line L1, and the dialysate outlet port 2d is connected to the dialysate outlet line L2. In order to perform effective dialysis treatment, the blood inlet port 2a, which is an inlet for blood, and the dialysate inlet port 2c, which is an inlet for dialysate, are configured to be opposite in the vertical positional relationship, and the dialysate flows in the direction in which the blood flowing through the blood channel 2e faces each other.
A plurality of hollow fiber membranes are housed inside the dialyzer 2, and the hollow fibers constitute a blood purification membrane 2g for purifying blood. That is, the blood flow path 2e is formed inside the blood purification membrane 2g constituting the hollow fiber membrane, and the dialysate flow path 2f is formed by the space between the housing and the hollow fiber. The blood purification membrane 2g is formed as a hollow fiber membrane, and is formed with a plurality of minute holes penetrating the outer peripheral surface and the inner peripheral surface thereof, so that impurities and the like in the blood flowing through the blood channel 2e via the membrane can permeate (be filtered) into the dialysate flowing through the dialysate channel 2 f.
The dialysate introduction line L1 is constituted by a flow path for introducing dialysate into the dialyzer 2, one end of which is connected to the dialysate introduction port 2c of the dialyzer 2, and a dialysate pump P2 is provided in the flow path in the middle. The dialysate pump P2 is constituted by a squeeze pump for stroking and feeding a flexible tube constituting a flow path of the dialysate introduction line L1, similarly to the blood pump P1. A dialysate receiving bag B1 that receives a predetermined amount of dialysate is connected to the other end of the dialysate introduction line L1, and the dialysate in the dialysate receiving bag B1 can be introduced into the dialyzer 2 by driving (forward driving) the dialysate pump P2.
The dialysate discharge line L2 is constituted by a flow path for discharging the discharged liquid from the dialyzer 2, one end of which is connected to the dialysate outlet port 2d of the dialyzer 2, and a liquid discharge pump P3 is provided in the flow path in the middle, and the liquid discharge pump P3 is constituted by a peristaltic pump which strokes and feeds a flexible tube constituting the flow path of the dialysate discharge line L2, similarly to the blood pump P1. A drain receiving bag B2 capable of receiving a predetermined amount of drain is connected to the other end of the dialysate discharge line L2, and the dialysate (drain) discharged from the dialyzer 2 can be introduced into the drain receiving bag B2 by driving (driving the drain pump P3 in the forward direction).
However, the dialysate in the dialysate receiving bag B1 flows and is supplied to the dialyzer 2 by the forward rotation driving of the dialysate pump P2, and the dialysate (drain) in the dialyzer 2 flows and is discharged to the drain receiving bag B2 by the forward rotation driving of the drain pump P3. The weight scales 4a and 4B are configured such that the weights of the dialysate receiving bag B1 and the drainage receiving bag B2 can be measured in real time by hooking and holding the dialysate receiving bag B1 and the drainage receiving bag B2 on a hook. The dialysate receiving bag B1 and the drainage receiving bag B2 are each constituted by a flexible receiving container, and the drainage receiving bag B2 is in an empty state in which drainage is not received before the blood purification treatment is started.
Further, the blood pump P1, the dialysate pump P2, and the drain pump P3 (and the fluid replacement pump P4) are driven based on the weights measured by the weight meters 4a and 4b and the previously stored set values. The driving speed of the drain pump P3 is controlled so as to be the same as the driving speed of the dialysate pump P2 when water removal from the patient is not performed as a treatment condition, and is configured so as to be a driving speed obtained in consideration of the flow rate of water when water removal is performed. When a difference between the theoretical weight and the weight of each of the dialysate receiving bag B1 and the drainage receiving bag B2 measured by the weight scales 4a and 4B occurs after a predetermined time has elapsed, the driving speed of the drainage pump P3 can be automatically adjusted to be fine so as to compensate for the difference.
The fluid replacement line L3 is constituted by a flow path that can communicate a predetermined portion of the venous blood circuit 1b (the blood circuit-side air trap chamber 3 connected to the venous blood circuit 1b in the present embodiment) with the dialysate introduction line L1. The substitution pump P4 is provided in the substitution line L3, and the substitution pump P4 is driven (forward rotation drive) to transfer the dialysate from the dialysate introduction line L1 to the vein blood circuit 1b and to perform substitution (post-substitution). The fluid replacement pump P4 is composed of a squeeze pump for stroking and feeding the flexible line constituting the fluid replacement line L3, similarly to the blood pump P1.
In addition, the dialysate introduction line L1 of the present embodiment includes: a dialysate-side air capture chamber 7, the dialysate-side air capture chamber 7 being disposed between the dialysate pump P2 and the dialyzer 2; an air discharge line Lb extending from an upper portion of the dialysate side air capture chamber 7 and configured to discharge air from the inside of the dialysate side air capture chamber 7; and an air discharge mechanism 10, wherein the air discharge mechanism 10 can discharge air inside the dialysate side air capture chamber 7 to the outside via an air discharge line Lb, and a liquid level detection mechanism 8 is attached to the dialysate side air capture chamber 7, and the liquid level detection mechanism 8 can detect the liquid level in the dialysate side air capture chamber 7.
The air discharge mechanism 10 includes a flow path communicating with the air discharge tube Lb, the tip of the flow path is opened to the atmosphere via a filter, and a squeeze pump Pb is provided in the flow path. The structure is as follows: the squeeze pump Pb can be driven in the forward rotation to discharge the air in the dialysate side air trapping chamber 7 to the outside, thereby increasing the liquid level in the dialysate side air trapping chamber 7, and the squeeze pump Pb can be driven in the reverse rotation to introduce the air into the dialysate side air trapping chamber 7, thereby reducing the liquid level in the dialysate side air trapping chamber 7.
The control means 11 is constituted by a microcomputer or the like provided in the blood purification apparatus, and is connected to actuators (the blood pump P1, the dialysate pump P2, the liquid discharge pump P3, the fluid replacement pump P4, and the like), various sensors (the liquid level detection means 6, 8, and the like), and a valve means (the gripping means 5, and the like), respectively, to perform various controls, and in the present embodiment, priming before blood purification treatment can be automatically performed by the control of the control means 11.
The priming is a step performed by driving the blood pump P1 to supply the priming solution to the blood circuit 1 (the arterial blood circuit 1a and the venous blood circuit 1b), and includes a priming solution filling step S1, a purging step S2, and a bubble discharge step S3, as shown in fig. 3. The priming solution filling step S1 is a step of filling the priming solution into the blood flow path 2e and the dialysate flow path 2f of the dialyzer 2 and replacing the priming solution with gas (air); the cleaning step S2 is a step of supplying the priming solution and cleaning the liquid by discharging the priming solution filled in the priming solution filling step S1 to the outside; the bubble discharge step S3 is a step of trapping bubbles remaining after the priming liquid is circulated in the flow path of the priming liquid for filling and cleaning, and discharging the trapped bubbles to the outside.
The distal ends of the arterial blood circuit 1a and the venous blood circuit 1B according to the present embodiment may be connected to a priming solution receiving bag B3 for receiving a priming solution (saline), and the priming solution of the priming solution receiving bag B3 may be supplied to the blood circuit 1 when the priming solution is filled. In the present embodiment, the priming solution receiving bag B3 is connected to the distal end portions of both the arterial blood circuit 1a and the venous blood circuit 1B, but it is sufficient if the priming solution receiving bag B3 is connected to at least the distal end portion of the arterial blood circuit 1 a.
Here, in the blood purification apparatus of the present embodiment, at the time of filling the priming solution (the priming solution filling step S1), as shown in fig. 2, in a state where the blood lead-out port 2b is directed upward (a state where the dialysate introduction port 2c is positioned above the dialysate lead-out port 2 d), the dialyzer 2 (blood purification means) is held, and the priming solution introduced into the blood channel 2e of the dialyzer 2 from the blood introduction port 2a is filtered into the dialysate channel 2f through the blood purification membrane 2g and is led out from the dialysate lead-out port 2c, whereby the dialysate channel 2f can be primed.
For example, if filling of the priming solution to be refilled is started (step S1 of filling the priming solution), as shown in fig. 4, the dialysate pump P2 and the drain pump P3 are driven in the forward direction at the same flow rate while the clamp mechanism 5 is closed, and the other pumps such as the blood pump P1 and the fluid replacement pump P4 are stopped. This allows the dialysate in the dialysate receiving bag B1 to flow and fill the connection part of the substitution line L3 of the dialysate introduction line L1.
After the above operation is completed, as shown in fig. 5, the blood pump P1 is driven in the forward direction while maintaining the closed state of the gripping mechanism 5, and the replacement fluid pump P4 is driven in the forward direction. At this time, the solenoid valve Va of the air discharge mechanism 9 is opened, the squeeze pump Pa is driven in the normal direction, and the other squeeze pumps such as the dialysate pump P2 and the drain pump P3 are stopped. The flow rate of the replacement fluid pump P4 is set to be equal to or less than the flow rate of the blood pump P1, and the driving speed of the squeeze pump Pa is controlled by the control means 11.
However, the priming solution (physiological saline) in the priming solution receiving bag B3 flows through the arterial blood circuit 1a, reaches the blood channel 2e of the dialyzer 2, is filtered by the blood purification membrane 2g, reaches the dialysate channel 2f, is discharged from the dialysate introduction port 2c, flows into the venous blood circuit 1B via the fluid replacement line L3, is filled in the circuit, and displaces the gas (air) in the channel. During the filling of the priming solution, the gas discharged from the venous blood circuit 1b (i.e., the air that has replaced the priming solution) is trapped in the blood circuit-side air trap chamber 3, and is discharged to the outside through the air discharge line La by the operation of the air discharge mechanism 9.
On the condition that the liquid level detection means 6 detects the liquid level at the predetermined height, the blood pump P1 and the substitution pump P4 are stopped, the electromagnetic valve Va of the air discharge means 9 is closed, and the squeeze pump Pa is stopped. However, instead of the priming operation described above, as shown in fig. 8, the blood purification apparatus may further include an opening/closing mechanism 12 that is provided between the connection between the dialyzer 2 of the venous blood circuit 1b and the fluid replacement line L3, and that can open and close the flow path as desired, and when filling the priming solution, the flow path can be closed by closing the opening/closing mechanism 12, and the gas (replaced air) discharged from the dialysate introduction port 2c of the dialyzer 2 can be discharged to the venous blood circuit 1b through the fluid replacement line L3.
In this manner, when the priming solution is filled (the priming solution filling step S1), the gas discharged from the dialysate introduction port 2c of the dialyzer 2 (i.e., the air that has been replaced with the priming solution) can be discharged to the venous blood circuit 1b via the solution replacement line L3. Further, when the priming solution is filled (priming solution filling step S1), by setting the flow rate of the priming solution pump P4 to be equal to or less than the flow rate of the blood pump P1, the gas discharged from the dialysate introduction port 2c of the dialyzer 2 (i.e., the air that has been replaced with the priming solution) can be discharged to the vein-side blood circuit 1b via the priming line L3.
Instead of the above-described method of discharging the gas (air substituted with the priming liquid) discharged from the dialysate inlet port 2c of the dialyzer 2 to the vein-side blood circuit 1b via the liquid replacement line L3, the following method may be used: the gas (air substituted with the priming solution) discharged from the dialysate introduction port 2c of the dialyzer 2 is captured by the dialysate side air capture chamber 7 of the dialysate introduction line L1, and the air discharge mechanism 10 is operated and discharged to the outside through the air discharge line Lb.
In this case, the dialysate pump P2 is driven in reverse so that the flow rate of the dialysate pump P2 is equal to or less than the flow rate of the blood pump P1, whereby the priming liquid introduced into the blood channel 2e of the dialyzer 2 from the blood introduction port 2a is filtered to the dialysate channel 2f through the blood purification membrane 2g, and is discharged from the dialysate introduction port 2c, whereby the dialysate channel 2f is primed. Accordingly, the air replaced with the priming liquid is trapped in the dialysate side air trap chamber 7, and therefore, the air discharge mechanism 10 can stop the discharge of the gas on condition that the liquid level detection mechanism 8 detects the liquid level at a predetermined height.
After the above operation, as shown in fig. 6, the blood pump P1 is driven in the forward direction while maintaining the closed state of the clamping mechanism 5, and the blood pump Pa is driven in the forward direction while opening the electromagnetic valve Va of the air discharge mechanism 9, whereby the air in the flow path from the connection part of the dialyzer 2 between the blood flow path 2e of the dialyzer 2 and the dialyzer 2 of the vein-side blood circuit 1b to the blood circuit-side air trap chamber 3 is replaced with the priming liquid. At this time, the driving speed of the squeeze pump Pa is controlled so that the liquid level detected by the liquid level detection means 6 is constant.
Further, the pinch pump Pa is stopped by opening the electromagnetic valve Va of the air discharge mechanism 9 while maintaining the normal rotation speed of the blood pump P1 and keeping the clamp mechanism 5 in the open state, and the gas discharged into the venous blood circuit 1B can be collected by the collection container (in the present embodiment, the priming solution receiving bag B3) connected to the distal end portion of the venous blood circuit 1B. Thereby, the priming liquid can be filled between the distal end of the vein-side blood circuit 1b and the blood circuit-side air trap chamber 3.
Further, as shown in fig. 7, when the priming solution receiving bag B3 is connected to the distal end portion of the venous blood circuit 1B, the pinch mechanism 5 is opened while the electromagnetic valve Va of the air discharge mechanism 9 is opened, and the squeeze pump Pa is driven in the normal rotation direction, whereby the air in the flow path between the distal end portion of the venous blood circuit 1B and the blood circuit air trap chamber 3 is replaced with the priming solution. Since the priming step S1 ends as described above, the washing step S2 and the bubble discharge step S3 are sequentially performed thereafter, whereby a series of priming operations ends.
In the cleaning step S2, if the priming solution supplied to the blood circuit 1 is to be discharged through the dialysate discharge line L2, the priming solution recovery bag connected only during priming may be eliminated, and the cost for priming may be reduced. In particular, in the present embodiment, since the fluid replacement line L3 is provided so as to be able to communicate the predetermined site of the venous blood circuit 1b with the dialysate introduction line L1, when the priming solution is discharged (cleaning step S2), if the priming solution supplied to the blood circuit 1 is discharged to the dialysate discharge line L2 by flowing it through the fluid replacement line L3, effective priming can be performed by using the fluid replacement line L3. After the completion of priming, when blood purification treatment is performed, the priming solution receiving bag B3 is removed from the tip portions of the arterial blood circuit 1a and the venous blood circuit 1B, and the puncture needle is connected thereto.
According to the above embodiment, at the time of filling the priming solution, the dialyzer 2 is held with the blood lead-out line 2B directed upward, and the priming solution (the physiological saline in the priming solution receiving bag B3) introduced into the blood channel 2e of the dialyzer 2 from the blood introduction port 2a is filtered into the dialysate channel 2f through the blood purification membrane 2g and can be led out from the dialysate introduction port 2c to precharge the dialysate channel 2f, so that the priming solution can be reliably filled into the blood channel 2e and the dialysate channel 2f of the dialyzer 2, and the reverse operation of the dialyzer 2 by the medical staff at the time of starting the blood purification treatment is not required. In addition, in the present embodiment, at the start of the blood purification treatment, the connection and replacement work of the receiving bag such as the dialysate bag B1 or the drain bag B2 is not necessary, and the workability can be further improved.
Further, the priming solution receiving bag B3 that receives the priming solution (saline) may be connected to at least the distal end portion of the arterial blood circuit 1a and the venous blood circuit 1B, and the priming solution of the priming solution receiving bag B3 may be supplied to the blood circuit 1 at the time of filling the priming solution, so that the filling of the priming solution on the blood circuit 1 side may be performed more reliably and smoothly.
Further, since the fluid replacement line L3 is provided so as to allow a predetermined portion of the venous blood circuit 1b to communicate with the dialysate introduction line L1, and gas discharged from the dialysate introduction port 2c of the dialyzer 2 can be discharged to the venous blood circuit 1b through the fluid replacement line L3 during filling of the priming fluid, more efficient priming can be performed. In particular, in the present embodiment, the substitution pump P4 is provided, and the substitution pump P4 is provided in the substitution line L3, and can transfer the dialysate from the dialysate introduction line L1 to the vein-side blood circuit 1b, and when the priming solution is filled for priming, the substitution pump P4 can be used to perform more effective priming because the gas discharged from the dialysate introduction port 2c of the dialyzer 2 can be discharged to the vein-side blood circuit 1b through the substitution line L3 by setting the flow rate of the substitution pump P4 to the flow rate of the blood pump P1 or less.
Further, the opening/closing mechanism 12 (see fig. 8) is provided between the connection part of the dialyzer 2 of the vein-side blood circuit 1b and the fluid replacement line L3, and the flow path can be opened and closed as desired, and if the flow path is closed by closing the opening/closing mechanism 12 at the time of filling the priming fluid, and the gas discharged from the dialysate introduction port 2c of the dialyzer 2 can be discharged into the vein-side blood circuit 1b through the fluid replacement line L3, the gas can be discharged through the fluid replacement line L3 more reliably, and more effective priming can be performed.
Further, at the time of filling the priming solution for priming, the gas discharged into the venous blood circuit 1B can be recovered by the recovery tank (in the present embodiment, the priming solution receiving bag B3) connected to the tip end portion of the venous blood circuit 1B, so that the gas of the priming solution can be more reliably recovered by replacement at the time of filling the priming solution. Further, a dedicated recovery vessel for recovering the gas at the distal end portion of the venous blood circuit 1b may be connected.
Further, at the time of filling the priming solution for priming, since the gas discharged into the venous blood circuit 1b can be captured by the blood circuit side air trap chamber 3 and the air discharge mechanism 9 is actuated to discharge the gas to the outside via the air discharge line La, the gas replaced with the priming solution at the time of filling the priming solution can be reliably discharged to the outside by using the blood circuit side air trap chamber 3 and the air discharge mechanism 9. In particular, since the liquid level detection means 6 capable of detecting the liquid level of the blood circuit side air trap chamber 3 is provided and the gas discharge from the air discharge means 9 is stopped on the condition that the liquid level at a predetermined height is detected by the liquid level detection means 6, the liquid level detection means 6 can detect that the priming solution is completely replaced with the gas, the priming operation can be terminated, and more effective priming can be performed.
Also, the apparatus comprises: a dialysate receiving bag B1 connected at the front end of the dialysate introduction line L1 by a dialysate receiving bag B1, which contains dialysate introduced into the dialyzer 2; a drain receiving bag B2, the drain receiving bag B2 being connected to the front end of the dialysate discharge line L2, the drain receiving bag B2 being capable of receiving drain discharged from the dialyzer 2; a dialysate pump P2 provided on the dialysate introduction line L1, the dialysate pump P2 transporting the dialysate in the dialysate receiving bag B1 to the dialyzer 2; since the drain pump P3 is provided in the dialysate discharge line L2 and the drain pump P3 feeds the drain discharged from the dialyzer 2 to the drain-receiving bag B2, more effective priming can be performed by following the dialysate pump P2 or the drain pump P3.
Furthermore, since the dialysate pump P2 is driven in reverse so that the flow rate of the dialysate pump P2 is set to be equal to or lower than the flow rate of the blood pump P1 at the time of filling with priming solution, priming solution introduced into the blood channel 2e of the dialyzer 2 from the blood introduction port 2a can be filtered into the dialysate channel 2f through the blood purification membrane 2g, and then discharged from the dialysate introduction port 2c, and the dialysate channel 2f can be primed, more effective priming can be performed by the cooperation between the dialysate pump P2 and the blood pump P1.
Further, when the gas discharged from the dialysate introduction port 2c is captured by the dialysate side air capture chamber 7 and the air discharge mechanism 10 is operated to discharge the gas to the outside through the air discharge line Lb at the time of filling the priming solution with the priming solution, the gas that has been substituted for the priming solution at the time of filling the priming solution can be reliably discharged to the outside by using the dialysate side air capture chamber 7 and the air discharge mechanism 10. In particular, if the liquid level detection means 8 capable of detecting the liquid level in the dialysate side air trap chamber 7 is provided and the air discharge means 10 stops discharging the gas on the condition that the liquid level detection means 8 detects the liquid level at a predetermined height, the priming operation can be terminated by detecting that the priming solution is completely replaced with the gas by following the liquid level detection means 8, and more effective priming can be performed.
While the present embodiment has been described above, the present invention is not limited to these embodiments, and may be applied to, for example, a blood purification apparatus including a compound pump 13 provided across the dialysate introduction line L1 and the dialysate discharge line L2 as shown in fig. 9; a bypass line L4, the bypass line L4 being connected to the dialysate discharge line L2 to bypass the compound pump 13; a water scavenging pump 14, the water scavenging pump 14 being connected to the bypass line L4. The blood purification device is configured in the following way: the dialysate introduction line L1 is connected to a water supply mechanism (not shown in the figure), and to a tank T1 containing a raw a fluid and a tank T2 containing a raw B fluid, and pumps 15 and 16 are driven to supply the raw a fluid and the raw B fluid to the dialysate introduction line L1, thereby producing a dialysate of a predetermined concentration and introducing the dialysate into the dialyzer 2.
Even in this case, at the time of filling the priming solution, the dialyzer 2 (blood purification means) is held with the blood lead-out port 2b facing upward, and the priming solution introduced into the blood channel 2e of the dialyzer 2 from the blood lead-in port 2a is filtered into the dialysate channel 2f through the blood purification membrane 2g, is led out from the dialysate lead-in port 2c, and is primed in the dialysate channel 2 f.
Further, it is also applicable to a blood purification apparatus not having the blood circuit side air trapping chamber 3, the dialysate side air trapping chamber 7, and the air discharging mechanisms 9, 10; or a blood purification apparatus without a substitution line L3 and a substitution pump P4. The blood purification means is not limited to the type of the blood purification membrane 2g formed of a hollow fiber membrane, and may be of another type that can purify blood and perform a treatment, and the blood purification treatment to be applied may be other treatment that purifies blood of a patient while extracorporeally circulating the blood, not limited to dialysis treatment.
Industrial applicability of the invention
In the case of priming the dialysate flow path, if the blood purification mechanism is held with the blood outlet port facing upward during filling of the priming solution, and the priming solution introduced into the blood flow path of the blood purification mechanism from the blood inlet port is filtered into the dialysate flow path through the blood purification membrane and is then drawn out from the dialysate inlet port to prime the dialysate flow path, another type of function may be added.
Description of reference numerals:
reference numeral 1 denotes a blood circuit;
reference numeral 1a denotes an arterial blood circuit;
reference numeral 8 denotes a liquid level detection mechanism;
symbol L1 denotes a dialysate introduction line;
symbol L2 denotes a dialysate discharge line;
symbol L3 denotes a fluid replacement line;
symbol P1 denotes a blood pump;
symbol P2 denotes a dialysate pump;
symbol P3 denotes a positive displacement pump;
the symbol P4 denotes a substitution pump.
Claims (11)
1. A blood purification device, comprising:
a blood purification mechanism including a blood introduction port into which blood can be introduced; a blood lead-out port capable of leading out blood; a blood channel extending in the range of the blood introduction port and the blood discharge port and allowing blood to flow therethrough; a dialysate introduction port into which dialysate can be introduced; a dialysate extraction port capable of extracting dialysate; a dialysate flow path extending in the range of the dialysate introduction port and the dialysate extraction port and allowing dialysate to flow in a direction facing the blood flowing through the blood flow path; a blood purification membrane interposed between the blood channel and the dialysate channel and capable of purifying blood flowing through the blood channel;
a blood circuit including an arterial blood circuit connected to the blood introduction port of the blood purification means and a venous blood circuit connected to the blood discharge port, the blood circuit being capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;
a dialysate introduction line connected to a dialysate introduction port of the blood purification mechanism and capable of introducing dialysate into the blood purification mechanism; a dialysate discharge line connected to the dialysate discharge port of the blood purification mechanism and capable of discharging the discharged fluid from the blood purification mechanism;
a blood pump provided in the arterial blood circuit and configured to be capable of extracorporeally circulating blood of the patient from the arterial blood circuit to the venous blood circuit and to supply a priming liquid to the blood circuit by driving the blood pump to perform priming,
wherein the blood purification means is held in a state in which the blood lead-out port is directed upward during filling of the priming solution for priming, and the priming solution introduced into the blood channel of the blood purification means from the blood lead-in port is filtered into the dialysate channel via the blood purification membrane and led out from the dialysate lead-in port to prime the dialysate channel,
the blood purification apparatus further includes a fluid replacement line that can communicate a predetermined portion of the arterial blood circuit with a dialysate introduction line, and can discharge gas discharged from a dialysate introduction port of the blood purification mechanism into the venous blood circuit via the fluid replacement line at the time of filling the priming fluid.
2. The blood purification apparatus according to claim 1, wherein a priming solution receiving bag that receives a priming solution is connectable to a distal end portion of at least the arterial blood circuit of the arterial blood circuit and the venous blood circuit, and the priming solution of the priming solution receiving bag is supplied to the blood circuit at the time of filling the priming solution.
3. The blood purification apparatus according to claim 1, comprising a substitution pump that is provided on the substitution line and is capable of delivering dialysate from the dialysate introduction line to the venous blood circuit, wherein a flow rate of the substitution pump is set to a flow rate of the blood pump or less at the time of filling the priming solution that is primed, and wherein gas discharged from the dialysate introduction port of the blood purification means is discharged to the venous blood circuit via the substitution line.
4. The blood purification apparatus according to claim 1, comprising an opening/closing mechanism provided between the blood purification mechanism of the venous blood circuit and a connection portion of the substitution line, the opening/closing mechanism being capable of opening and closing a flow path arbitrarily, and being capable of closing the flow path by closing the opening/closing mechanism at the time of filling the priming solution, thereby discharging gas discharged from the dialysate introduction port of the blood purification mechanism into the venous blood circuit via the substitution line.
5. The blood purification apparatus according to claim 1, 3 or 4, wherein the gas discharged into the venous blood circuit can be recovered by a recovery vessel connected to the distal end portion of the venous blood circuit at the time of filling the priming liquid.
6. A blood purification device according to claim 1, 3 or 4, characterized in that it comprises: a blood circuit-side air trap chamber provided at a connection portion of the fluid replacement line of the vein-side blood circuit;
an air discharge line extending from an upper portion of the blood circuit side air trap chamber and capable of discharging air in the blood circuit side air trap chamber;
an air discharge mechanism capable of discharging the air in the blood circuit side air capturing chamber to the outside through the air discharge line,
the air discharge mechanism is configured to be able to capture the gas discharged into the venous blood circuit by the blood circuit-side air capture chamber and to be able to operate the air discharge mechanism to discharge the gas to the outside through the air discharge line during filling of the priming liquid.
7. The blood purification apparatus according to claim 6, comprising liquid level detection means capable of detecting a liquid level in the blood circuit side air trap chamber and stopping the discharge of the gas by the air discharge means on condition that the liquid level detection means detects a liquid level at a predetermined height.
8. A blood purification device according to claim 1, characterized in that it comprises:
a dialysate receiving bag connected to a distal end portion of the dialysate introduction line, the dialysate receiving bag receiving dialysate introduced into the blood purification mechanism;
a drain receiving bag connected to a distal end portion of the dialysate discharge line and capable of receiving the drain discharged from the blood purification mechanism;
a dialysate pump that is provided on the dialysate introduction line and that delivers the dialysate of the dialysate receiving bag to the blood purification mechanism;
and a drain pump provided on the dialysate discharge line and configured to transport the drain discharged from the blood purification mechanism to the drain receiving bag.
9. The blood purification apparatus according to claim 8, wherein the dialysate pump is driven in reverse so that a flow rate of the dialysate pump becomes equal to or lower than a flow rate of the blood pump at the time of filling the priming solution with the priming solution, so that the priming solution introduced into the blood channel of the blood purification mechanism from the blood introduction port is filtered into the dialysate channel through the blood purification membrane, and is discharged from the dialysate introduction port to prime the dialysate channel.
10. A blood purification device according to claim 8 or 9, characterized in that it comprises:
a dialysate side air trap chamber provided between the dialysate pump of the dialysate introduction line and the blood purification mechanism;
an air discharge line extending from an upper portion of the dialysate side air capture chamber and capable of discharging air in the dialysate side air capture chamber;
an air discharge mechanism capable of discharging air in the dialysate side air trap chamber to the outside through the air discharge line,
when the priming solution is filled in the priming chamber, the gas discharged from the dialysate introduction port is captured by the dialysate side air capture chamber, and the air discharge mechanism is operated to discharge the gas to the outside through the air discharge line.
11. The blood purification apparatus according to claim 10, comprising liquid level detection means capable of detecting the liquid level in the dialysate side air capture chamber and stopping the discharge of gas by the air discharge means on condition that the liquid level detection means detects the liquid level at a predetermined height.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-207023 | 2015-10-21 | ||
| JP2015207023A JP6933439B2 (en) | 2015-10-21 | 2015-10-21 | Blood purification device |
| PCT/JP2016/081011 WO2017069171A1 (en) | 2015-10-21 | 2016-10-19 | Blood purification device |
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| CN108136100A CN108136100A (en) | 2018-06-08 |
| CN108136100B true CN108136100B (en) | 2020-10-13 |
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| JP (1) | JP6933439B2 (en) |
| CN (1) | CN108136100B (en) |
| WO (1) | WO2017069171A1 (en) |
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| EP4029539A1 (en) | 2015-04-07 | 2022-07-20 | NxStage Medical Inc. | Blood treatment device priming devices, methods, and systems |
| JP6775056B2 (en) * | 2019-04-01 | 2020-10-28 | 日機装株式会社 | Blood purification device |
| JP2024004226A (en) * | 2022-06-28 | 2024-01-16 | 日機装株式会社 | blood purification device |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1830494A (en) * | 2006-04-12 | 2006-09-13 | 重庆山外山科技有限公司 | Medical hemodialysis filter |
| JP2010125208A (en) * | 2008-11-28 | 2010-06-10 | Asahi Kasei Kuraray Medical Co Ltd | Blood extracorporeal circulation apparatus and method of priming the same |
| CN104837515A (en) * | 2012-12-13 | 2015-08-12 | 德国弗雷泽纽斯医疗保健股份有限公司 | Device and method for monitoring extracorporeal blood circulation for detection of air bubbles |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910252A (en) * | 1993-02-12 | 1999-06-08 | Cobe Laboratories, Inc. | Technique for extracorporeal treatment of blood |
| ES2402306T3 (en) * | 2007-04-12 | 2013-04-30 | Gambro Lundia Ab | Method and apparatus for priming an extracorporeal blood circuit |
| JP5548001B2 (en) * | 2010-03-25 | 2014-07-16 | 日機装株式会社 | Blood purification equipment |
| EP2465555B1 (en) * | 2010-12-20 | 2014-01-15 | Gambro Lundia AB | Method and system for providing priming and restitution liquids for an extracorporeal blood treatment |
| JP2013248334A (en) * | 2012-06-04 | 2013-12-12 | Nikkiso Co Ltd | Blood purifying device and priming method therefor |
| EP2883558B1 (en) * | 2012-08-09 | 2017-08-02 | Nikkiso Company Limited | Blood purification device and priming method therefor |
| US9623164B2 (en) * | 2013-02-01 | 2017-04-18 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
-
2015
- 2015-10-21 JP JP2015207023A patent/JP6933439B2/en active Active
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2016
- 2016-10-19 WO PCT/JP2016/081011 patent/WO2017069171A1/en active Application Filing
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1830494A (en) * | 2006-04-12 | 2006-09-13 | 重庆山外山科技有限公司 | Medical hemodialysis filter |
| JP2010125208A (en) * | 2008-11-28 | 2010-06-10 | Asahi Kasei Kuraray Medical Co Ltd | Blood extracorporeal circulation apparatus and method of priming the same |
| CN104837515A (en) * | 2012-12-13 | 2015-08-12 | 德国弗雷泽纽斯医疗保健股份有限公司 | Device and method for monitoring extracorporeal blood circulation for detection of air bubbles |
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| JP2017077383A (en) | 2017-04-27 |
| WO2017069171A1 (en) | 2017-04-27 |
| JP6933439B2 (en) | 2021-09-08 |
| CN108136100A (en) | 2018-06-08 |
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