CN109187475A - A kind of detection device and its gene detection equipment - Google Patents
A kind of detection device and its gene detection equipment Download PDFInfo
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- CN109187475A CN109187475A CN201811079471.0A CN201811079471A CN109187475A CN 109187475 A CN109187475 A CN 109187475A CN 201811079471 A CN201811079471 A CN 201811079471A CN 109187475 A CN109187475 A CN 109187475A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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Abstract
The invention discloses a kind of detection device and its gene detection equipments, including, front panel, front panel is fixed by side panel and restoring board assembly；Rear panel hinged block is provided on rear panel, rear panel hinged block is hinged by panel articulated shaft and the cover board hinged block on cover board；Cover board is used for pressing clip frame component, presss from both sides in frame component and is equipped with genetic chip；Folder frame component is mounted in detection slot, detection slot is arranged on the inside of detection block, detection block is fixed by detection bottom plate and bottom panel assembly, supporting plate is provided in detection slot, below folder frame component, it is provided with supporting plate through-hole on supporting plate, and assembly is fixed at the top of supporting plate bottom surface and resetting shaft, location hole is provided at the top of resetting shaft, resets bulge loop, it presss from both sides after frame positioning column passes through supporting plate through-hole and is assembled with location hole, assemble and fix with supporting plate after circuit board, fixed plate at the top of resetting shaft；Resetting shaft bottom is packed into reset guide cylinder, is adjacent at the top of resetting shaft bottom and reset spring, reset spring bottom is adjacent to detection bottom plate.
Description
Technical field
The present invention relates to a kind of technique of gene detection, more particularly to a kind of detection device and its gene detection equipment.
Background technique
Gene (gene) is complete nucleotide sequence needed for generating a polypeptide chain or function RNA.Gene is supported
The essential structure and performance of life.The race of life is stored, blood group, breeds, grow, all information of the processes such as apoptosis.
Environment and genetics interdepend, the important physiology course such as procreation, cell division and protein synthesis of life of deducing.Biology
Body it is sick, long, decline, old, all life phenomenon of waiting indefinitely is all related with gene.It is also the internal factor for determining life and health.
Therefore, gene has double attribute: materiality (existing way) and informedness (fundamental nature).
Detecting disease by detection gene has been very mature technology, mainly passes through Electrochemistry gene chip at present
It is detected, electrochemical gene is based on as disclosed in the Chinese patents such as Publication No. CN103224878A, CN105861293B
The gene detection equipment of chip.
Genetic chip needs to access reagent, the electric current or fluorescence that then detection reagent issues in genetic chip, thus real
Now to the detection of gene.But the gene detection equipment based on Electrochemistry gene chip is in actual use, it is found that access reagent
The pipeline sealing generally difficult to realize with the reagent access port of genetic chip；And experiment when, need to genetic chip into
Row heating, is generally required to be adjacent to using heating device and be heated on genetic chip to gene, then how to solve gene core
Piece and being adjacent to for heating device are also a problem.General use directly compresses genetic chip on the heating, this mode
Although effect is good, and simple, chip is be easy to cause to be subject to crushing.
Therefore applicant proposes a kind of detection device and its gene detection equipment, can be realized the preferable of reagent access port
Sealing, and can also effective protection chip be not subject to crushing.
Summary of the invention
In view of the above drawbacks of the prior art, technical problem to be solved by the invention is to provide a kind of detection device and
Its gene detection equipment.
To achieve the above object, the present invention provides a kind of detection devices, including, front panel, rear panel, rear panel are fixed
On bottom panel, the front panel is fixed by side panel and restoring board assembly；
Rear panel hinged block is provided on the rear panel, the rear panel hinged block passes through on panel articulated shaft and cover board
Cover board hinged block it is hinged；Cover board is for closing at the top of detection slot, and pressing clip frame component, presss from both sides in frame component and is equipped with gene core
Piece；
The folder frame component is mounted in detection slot, and detection slot is arranged on the inside of detection block, and the detection block passes through detection
Bottom plate and bottom panel assembly are fixed, and are provided with supporting plate in the detection slot, below folder frame component, are provided on the supporting plate
Supporting plate through-hole, and assembly is fixed at the top of supporting plate bottom surface and resetting shaft, and location hole is provided at the top of resetting shaft, resets bulge loop, presss from both sides frame
Positioning column assembles after passing through supporting plate through-hole with location hole, fills after circuit board, fixed plate are passed through at the top of the resetting shaft with supporting plate
With fixation；
The resetting shaft bottom is packed into reset guide cylinder, resets the assembly that can slide axially inside bulge loop and reset guide cylinder,
And be adjacent at the top of resetting shaft bottom and reset spring, reset spring bottom is adjacent to detection bottom plate.
Preferably, rotatably mounted on the fuselage to have clamping lock axis, it is fixed with clamping lock positioning plate on the clamping lock axis,
Preceding conducting block is installed on the inside of the clamping lock positioning plate, the preceding conducting block contacts conduction with pre-positioning block, so that
First detection circuit forming circuit；
One end end face that the detection device is packed into detection mounting groove is rear panel, is led after being provided on the rear panel
Electric block, rear conducting block contacts conduction with the post-positioning block being mounted on the inside of detection mounting groove, so that the second detection circuit shape
At circuit.
Preferably, the bottom panel bottom is provided with draw runner, and the draw runner can be in fuselage sliding slot and supporting plate sliding slot
Sliding, the setting of fuselage sliding slot installs trench bottom in detection, and fuselage sliding slot and supporting plate sliding slot are interconnected, and the setting of supporting plate sliding slot exists
On fuselage supporting plate.
Preferably, be additionally provided on the cover board cover board observation slot, cover board link block, cover board closing piece, the first reagent passage,
Second reagent passage, the cover board observation slot is for penetrating optical detection sem observation camera lens, to carry out to genetic chip
Observation.
Preferably, the cover board closing piece is connected by cover board link block and cover board far from panel articulated shaft one end；It is described
Cover board closing piece by handle compress so that cover board to genetic chip compress, the handle both ends are respectively arranged with handle
Hand shaft, handle shaft are packed into the recessing groove of handle mounting blocks, and the handle shaft can be in recessing groove, on vertical direction
Sliding；
Handle shaft one end is pierced by recessing groove, and traversing through end connect axis connection with the closing piece on elastic force closing piece by elastic drawstring and consolidates
Fixed, the elastic drawstring has high resiliency；The handle mounting blocks, elastic force closing piece are fixed on front panel.
Preferably, the first described reagent passage one end is connected to reagent hose, the other end is connected to the second reagent passage；
The second reagent passage open end periphery is fixed with the first sealing ring, and first sealing ring is connected to block with reagent
On third reagent passage one end around compress sealing, be provided with the second sealing around the third reagent passage other end
It encloses, sealing is compressed around the reagent wells on second sealing ring and genetic chip.
Preferably, reagent wells, the first reagent passage, the second reagent passage, third reagent passage it is equal there are two, a part make
The channel of genetic chip, channel of the another part as reagent outflow genetic chip are flowed into for reagent.
Preferably, the folder frame component includes the second folder frame, the first folder frame, and reagent is connected to block setting and presss from both sides frame first
On, the first through slot, the first clip slot, strip, folder frame hinged block are additionally provided on the first folder frame, the strip both ends are respectively arranged with
It is closed card slot；
The observation that first through slot is used to that the first folder frame to be made not block optical detection mirror, first clip slot and gene core
One end face clamping of piece；
The second through slot, the second clip slot, locking card slot, resigning short slot, buckle slot, folder, which are provided with, on the second folder frame confines position
Column, second through slot after so that heating sheet is passed through the second folder frame with genetic chip for being adjacent to, to carry out to genetic chip
Heating；
Second clip slot and the clamping of genetic chip other end, makes it cooperate clamping genetic chip with the first clip slot；
The folder frame hinged block is packed into resigning short slot, and folder frame articulated shaft passes through folder frame hinged block, the second folder frame, so that first
It presss from both sides frame and the second folder frame is hinged
Second clip slot is fixed with card in the buckle slot far from buckle slot is provided on the inside of folder frame articulated shaft one end
It detains, snap fit tabs is provided on the buckle, the snap fit tabs are packed into card slot, thus by the first folder frame and the second folder
Frame is to fixation.
A kind of application has the gene detection equipment of above-mentioned detection device, further includes, pedestal, fixes on the pedestal organic
Body, the fuselage are fixed by fuselage connecting column and fuselage roof assembly, are fixed with fuselage supporting plate on the pedestal, described
Fuselage on be provided with detection mounting groove, detect in mounting groove and detection device, and the detection mounting groove open end be installed
On be fixed with detection end plate, detect that be provided on end plate can be with the end plate mating groove of detection device snap-fit；The fuselage
Optical detection mirror is fixed between top surface and fuselage roof.
It preferably, further include latch assembly, latch assembly includes front panel, side panel, is provided on the side panel
First flange and the second flange, switch sliding slot is provided on the detection bottom plate, and second flange is packed into switch sliding slot
It is interior and slidably assemble therewith, first flange bottom surface and detection block clamping, the restoring board and detection block side it
Between form switch gap；
The side panel is provided with switch slot on the side of detection block, switchs and is equipped with switch block in slot, on switch block
It is provided with switch inclined-plane；
Switch inclined-plane is adjacent to first mandril one end, and the first mandril other end is packed into reset hole after passing through stop collar, described
Stop collar is mounted on reset hole one end, and the reset hole other end is connected to slide opening, and the slide opening, reset hole are arranged at detection
On frame side wall；
First mandril, which is packed on one end of reset hole, is provided with card tieholen, and card tieholen closed end and the assembly of the first spring one end are solid
Fixed, one end of the first spring other end and the second mandril loading card tieholen, which is assembled, to be fixed, after the second mandril other end passes through slide opening
With locking card slot snap-fit；
It is further fixed on reset ring on one end that first mandril is packed into reset hole, resets ring and reset hole close to slide opening one
Second spring is provided between the end face at end；
Arc-shaped spring piece is installed, the arc-shaped spring piece arc top part and restoring board assembly are solid in the switch gap
Fixed, both ends are adjacent to detection block.
The beneficial effects of the present invention are:
1, the present invention realizes the protection to genetic chip by folder frame component, so that genetic chip be prevented to be subject to crushing.
2, detection device of the invention can be realized the automatic ejection of folder frame component, and can be realized by positioning component
The accurate positionin of detection device improves detection accuracy to guarantee the consistency of observation position.
3, latch assembly of the invention, initial position limits when can be realized folder frame component installation, and its unfolding mode
Also very simple, total is merged with detection block, detection device, and simplifies structure, and facilitates operation.
4, the present invention is by advance installing folder frame component, then in such a way that cover board auxiliary compresses, Neng Gouyou
Effect prevents folder frame component from upwarping, shifting.And folder frame component also achieves the connection of the sealing to reagent wells.
Detailed description of the invention
Fig. 1-Fig. 3 is structural schematic diagram of the invention.
Fig. 4-Fig. 7, Fig. 9-Figure 12, Figure 19-Figure 20 are the structural schematic diagrams of detection device of the present invention.Wherein Figure 11 is Figure 10
Enlarged drawing at middle F1；Figure 20 is enlarged drawing at F5 in Figure 19.
Fig. 8 is positioning component structural schematic diagram of the invention.
Figure 13, Figure 15, Figure 17 are respectively A-A, B-B(perspective view in Figure 12), shape of the C-C cross-sectional view in perspective view
State.
Figure 14, Figure 16, Figure 18 are respectively enlarged drawing at F4 at F2, in Figure 15 at F3, in Figure 17 in Figure 13.
Figure 21-Figure 25 is detection device partial structure diagram of the present invention.Wherein Figure 25 is enlarged drawing at F6 in Figure 24.
Figure 26-Figure 27 is the explosive view of detection device of the present invention.
Figure 28-Figure 30 is the structural schematic diagram of present invention folder frame component.
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and examples:
Referring to figures 1-3 0, a kind of gene detection equipment, including, pedestal 110 is fixed with fuselage 120 on the pedestal 110,
The fuselage 120 is fixed by fuselage connecting column 130 and the assembly of fuselage roof 140, is fixed with fuselage on the pedestal 110
Supporting plate 150 is provided with detection mounting groove 121 on the fuselage 120, detects in mounting groove 121 and be equipped with detection device, detects
Device is fixed with detection end plate 160 for carrying out genetic test on 121 open end of detection mounting groove, detect end plate
Being provided on 160 can be with the end plate mating groove 161 of detection device snap-fit；
Optical detection mirror 210 is fixed between 120 top surface of fuselage and fuselage roof 140, optical detection mirror 210 is for seeing
The fluorescence on genetic chip is examined, to be detected, can specifically be referred in the Chinese patent of Publication No. CN105861293B
Full transmitting microscope；
It is provided with supporting plate sliding slot 151 on the fuselage supporting plate 150, it is rotatably mounted on the fuselage 120 to have clamping lock axis
170, clamping lock positioning plate 171 is fixed on the clamping lock axis 170, and preceding conduction is installed on the inside of the clamping lock positioning plate 171
Block 172, the preceding conducting block 172 and pre-positioning block 442 contact conduction, so that the first detection circuit is formed into a loop, this
When can be assumed that and be adjacent to for clamping lock positioning plate 171 and the front panel 440 of detection device.First detection circuit, including, electricity
Pond, current sensor, resistance, the anode and preceding conducting block 172 connect conductive, cathode and resistance and terminate admittance into electricity
Electricity, resistance current output terminal and current sensor are led into electricity termination admittance electricity, current sensor current output terminal with the connection of pre-positioning block 442
Electricity.When current conducting block 172 is contacted with pre-positioning block 442, the first detection circuit forming circuit, current sensor detects electricity
Stream can regard as front panel 440 and the assembly of clamping lock positioning plate 171 in place at this time.
The preceding conducting block 172, pre-positioning block 442, the first detection circuit collectively form positioning component.
Referring to Fig. 5, Fig. 8, one end end face that the detection device is packed into detection mounting groove 121 is rear panel 410, institute
Rear conducting block 412, rear conducting block 412 and the post-positioning block being mounted on the inside of detection mounting groove are provided on the rear panel 410 stated
122 contacts are conductive, so that the second detection circuit is formed into a loop.
Second detection circuit, including, battery, current sensor, resistance, the anode and rear conducting block
412 connect conductive, cathode and resistance, and into electric termination admittance, electric, resistance current output terminal and current sensor are electric into electricity termination admittance, electricity
Flow sensor current output terminal and post-positioning block 122 connect conduction.When rear conducting block 412 is contacted with post-positioning block 122, the second detection
Circuit forming circuit, current sensor detect electric current, can regard as conducting block 412 and the assembly of post-positioning block 122 at this time in place.
Conducting block 412 and post-positioning block 122, the second detection circuit collectively form another positioning component.It is positioned by two
The design of component can regard as detection device peace as long as two positioning components constitute circuit after guaranteeing detection device installation
It is attached to position, accurate detection is just able to carry out without other structures.It can effectively ensure that 210 camera lens of optical detection mirror position always
Above preset genetic chip, guarantee the accuracy of observation.
The detection device, including, front panel 440, rear panel 410, rear panel 410 are fixed on bottom panel 420, institute
The front panel 440 stated is fixed by side panel 430 and the assembly of restoring board 450, is adjacent on the inside of restoring board 450 and rear panel 410；
420 bottom of bottom panel is provided with draw runner 421, and the draw runner 421 can be in fuselage sliding slot 111 and supporting plate sliding slot
Sliding in 151, the setting of fuselage sliding slot 111 installs trench bottom in detection, and fuselage sliding slot 111 and supporting plate sliding slot 151 are interconnected；
Rear panel hinged block 411 is provided on the rear panel 410, the rear panel hinged block 411 is hinged by panel
Cover board hinged block 311 on axis 230 and cover board 310 is hinged (rotatably assembly).
Referring to Fig. 7, clamping lock positioning plate 171 turns over pre-positioning block 442 in order to prevent, can below pre-positioning block 442, it is preceding
Spacing block set 441 is installed on panel 440, in use, by clamping lock positioning plate 171 turn to the top of spacing block set 441 and with limit
Convex block 441 is adjacent to.
Referring to Figure 11, Figure 16, cover board observation slot 312, cover board link block 313, cover board lock are additionally provided on the cover board 310
Block 314, the first reagent passage 315, the second reagent passage 316, the cover board observation slot 312 is for making optical detection sem observation
Camera lens penetrates, to observe genetic chip；
The cover board closing piece 314 is connect with cover board 310 far from 230 one end of panel articulated shaft by cover board link block 313；Referring to
Fig. 7, the cover board closing piece 314 are compressed by handle 446, so that cover board 310 is compressed to genetic chip 520, it is described
446 both ends of handle are respectively arranged with handle shaft 445, and handle shaft 445 is packed into the recessing groove 4441 of handle mounting blocks 444,
The handle shaft 445 can be slided in recessing groove 4441, on vertical direction；
445 one end of handle shaft is pierced by recessing groove 4441, and traversing through end passes through the lock on elastic drawstring 240 and elastic force closing piece 443
Block connecting shaft 4431 is connected and fixed, and the elastic drawstring 240 has high resiliency, can use rubber, silica gel, the poly- second of high resiliency
The production such as alkene fiber；
When handle 446 is not with cover board 314 clamping of closing piece, handle shaft 445 is pulled down to recessing groove under the effect of elastic drawstring 240
Then 4441 bottoms pass through handle so that handle 446 can be rotated centered on handle shaft 445 as 440 upright position of front panel
Hand can be driven detection device and be slided in fuselage sliding slot 111, supporting plate sliding slot 151 by draw runner 421.It mainly will test device
Pull out detection mounting groove.
When needing handle 446 and 314 clamping of cover board closing piece, elastic drawstring elastic force is overcome to pull up handle 446, until handle
446 inside of hand and the 314 clamping clamping of cover board closing piece, this design is so that handle can either treat as different handle applications, again
It can be to kill two birds with one stone, can effectively simplify structure by 240 clamping cover board 310 of elastic drawstring.
The handle mounting blocks 444, elastic force closing piece 443 are fixed on front panel 440.
Described 315 one end of the first reagent passage is connected to reagent hose 220, the other end and the second reagent passage 316 connect
It is logical, in use, the reagent for needing to carry out genetic test enters the first reagent passage 315 from reagent hose 220, then from the second examination
Agent channel 316 is discharged；
Second reagent passage, the 316 open end periphery is fixed with the first sealing ring 251, first sealing ring 251 with
Reagent, which is connected to around 3211 one end of third reagent passage on block 321, compresses sealing, and the third reagent passage 3211 is another
The second sealing ring 252, second sealing ring 252 and the 521 surrounding pressure of reagent wells on genetic chip 520 are provided with around end
Close envelope, so that reagent wells 521 can be entered by reagent hose under not leak condition by allowing for reagent；
There are two reagent wells 521, the first reagent passage 315, the second reagent passage 316, third reagent passage 3211 are equal, use
When, a part flows into the channel of genetic chip, channel of the another part as reagent outflow genetic chip as reagent.Although base
It is generally to be cleaned (mainly internal guidance reagent replacing another reagent still because chip is disposable
The channel of flowing), this is just needed the reagent outflow in genetic chip.
2- Figure 30 referring to fig. 2, reagent connection block 321 setting is on the first folder frame 320, the first folder frame
320 belong to folder frame component, and the folder frame component further includes the second folder frame 330, are additionally provided with the first through slot on the first folder frame 320
322, the first clip slot 323, strip B310, folder frame hinged block B110, the both ends strip B310 are respectively arranged with closure card slot
B311；
The observation that first through slot 322 is used to that the first folder frame 320 to be made not block optical detection mirror 210, first folder
Slot 323 and 520 1 end face clamping of genetic chip；
Be provided on the described second folder frame 330 second through slot 336, the second clip slot 335, locking card slot 332, resigning short slot 333,
Buckle slot 334, folder frame positioning column 331, second through slot 336 for make heating sheet 540 pass through second folder frame 330 after with base
Because chip is adjacent to, to be heated to genetic chip；
Second clip slot 335 and 520 other end clamping of genetic chip, make it cooperate clamping gene with the first clip slot 323
Chip 520；
The folder frame hinged block B110 is packed into resigning short slot 333, and folder frame articulated shaft B210 passes through folder frame hinged block B110, the
Two folder frames 330, so that the first folder frame 320 and the second folder frame 330 are hinged, that is, the first folder frame 320 and the second folder frame 330 can lead to
Cross folder frame articulated shaft B210 relative rotation；
Buckle slot 334, the buckle slot are provided on the inside of described separate folder one end frame articulated shaft B210 of the second clip slot 335
It is fixed in 334 on buckle B410, the buckle B410 and is provided with snap fit tabs B411, the snap fit tabs B411 is packed into
In card slot B311, thus by the first folder frame 320 and the second folder frame 330 to fixation.
In use, only needing firmly to break the first folder frame 320 and the second folder frame 330 into two with one's hands, so that snap fit tabs B411 is detached from
Card slot B311, that is, openable first folder frame 320 and the second folder frame 330.Snap fit tabs B411 stretches out buckle slot 334, and institute after opening
The buckle B410 stated has elasticity, and in Figure 25 state, snap fit tabs B411 is squeezed so that buckling B410 storage elastic force.It beats
After opening the first folder frame 320 and the second folder frame 330, snap fit tabs B411 stretches out buckle slot 334 under the action of buckling B410 elastic force.
The folder frame component is mounted in detection slot 511, and the setting of detection slot 511 is in 510 inside of detection block, the inspection
It surveys frame 510 and is fixed by detecting bottom plate 350 and the assembly of bottom panel 420, in the detection slot 511, press from both sides setting below frame component
There is supporting plate 340, supporting plate through-hole 341 is provided on the supporting plate 340, and assembly is solid at the top of 340 bottom surface of supporting plate and resetting shaft 260
It is fixed, location hole 261 is provided at the top of resetting shaft 260, resets bulge loop 262, folder frame positioning column 331 pass through after supporting plate through-hole 341 with
Location hole 261 assembles, and fixes after circuit board 530, fixed plate 360 are passed through at the top of the resetting shaft 260 with the assembly of supporting plate 340,
And resetting shaft 260 and circuit board 530, fixed plate 360 are slided relatively；
260 bottom of resetting shaft is packed into reset guide cylinder 270, and resetting can axis inside bulge loop 262 and reset guide cylinder 270
It is adjacent to slidable fit, and at the top of 260 bottom of resetting shaft and reset spring 280,280 bottom of reset spring and detection bottom plate 350
It is adjacent to.
In use, resetting shaft 260 moves up under the supporting role of reset spring, to supporting plate 340 be jacked up upwards, then
The folder frame component for having clamped genetic chip is put into detection slot 511, so that after folder frame positioning column 331 passes through supporting plate through-hole 341
It is assembled with location hole 261, then the elastic force of reset spring can be overcome to push genetic chip by pushing folder frame component, work as lid
It is compressible genetic chip 520 by cover board 310 after plate 310 is closed, so that genetic chip 520 is adjacent to heating sheet 540, and
Reagent wells are connected to the sealing of reagent hose respectively, since active force does not act directly on genetic chip, it is possible to prevent base
Because chip is subject to crushing.And installation site of the adjustable fixed plate 360 in detection slot, moving down for folder frame component can be limited
Distance can also further prevent genetic chip and heating sheet 540 excessively to compress and cause genetic chip impaired.
Since when in use, once opening cover board, folder frame component will will press from both sides frame group under the effect of the elastic force of reset spring
Part jacks up upwards, and presss from both sides frame component and only pass through folder frame positioning column 331 and the assembly of location hole 261, this allows for cover board and was switching
Folder frame component unilateral side stress is caused in journey, can accelerate the abrasion for pressing from both sides frame positioning column 331 and location hole 261, or even folder is caused to confine
Position column 331 and location hole 261 be detached from, influence using.Therefore, applicant proposes latch assembly to solve the problems, such as this.
Referring to Figure 14-15, Figure 18-20, the latch assembly, including, front panel 440, side panel 430, the side
It is provided with the first flange 431 and the second flange 432 on panel 430, switch sliding slot 351 is provided on the detection bottom plate 350,
Second flange 432 is packed into switch sliding slot 351 and slidably assembles therewith, 431 bottom surface of the first flange and inspection
510 clamping of frame is surveyed, so that side panel 430 opposite with detection block 510 can slide, the restoring board 450 and detection block 510
Switch gap 401 is formed between side, and arc-shaped spring piece 250, the arc spring are installed in the switch gap 401
250 arc top part of piece and the assembly of restoring board 450 are fixed, and both ends are adjacent to detection block 510；This is allowed for, when original state, in arc
Under the effect of 250 elastic force of shape spring leaf, restoring board 450 always far from detection block 510, that is, front panel 440 always with detection block
510 are adjacent to；
The side panel 430 is provided with switch slot 433 on the side of detection block 510, switchs in slot 433 and is equipped with switch
Be provided with switch inclined-plane A111 on block A110, switch block A110, referring to fig. 20, the switch inclined-plane A111 by restoring board forward
Panel is gradually tilted to the left；
Switch inclined-plane A111 is adjacent to first one end mandril A210, and the first mandril A210 other end is packed into after passing through stop collar A420
In reset hole 514, the stop collar A420 is mounted on 514 one end of reset hole, and 514 other end of reset hole and slide opening 513 connect
Lead to, the slide opening 513, reset hole 514 are arranged on 510 side wall of detection block；
First mandril A210 is packed on one end of reset hole 514 and is provided with card tieholen A211, the closed end card tieholen A211 and first
The assembly of the one end spring A310 is fixed, and one end of the first spring A310 other end and the second mandril A220 loading card tieholen A211 are assembled
It is fixed, the second mandril A220 other end pass through after slide opening 513 with locking 332 snap-fit of card slot；
Be further fixed on one end that the first mandril A210 is packed into reset hole 514 and reset ring A410, reset ring A410 with
Reset hole 514 is provided with second spring A320 between the end face of 513 one end of slide opening, and second spring A320 makes for generating
The power that one mandril is slided to switch block A110.
When needing to install or remove genetic chip, handle 446 is separated with cover board closing piece 314 first, then swing handle,
And device will test by handle and pulled to fuselage supporting plate direction, at this point, detection device is by draw runner 421 in fuselage sliding slot 111
It is slided in supporting plate sliding slot 151, until draw runner 421 slides into 151 closed end of supporting plate sliding slot.In the process, due to there is arc
The elastic force of spring leaf 250 acts on, and side panel 430 will not relatively move between detection block 510, that is, can guarantee open
It closes and is not relatively moved between inclined-plane A111 and the first mandril.This needs the elastic force of arc-shaped spring piece to be greater than draw runner and fuselage
The frictional force of sliding slot, supporting plate sliding slot；
After draw runner and 151 end face of supporting plate sliding slot are adjacent to, detection device cannot continue to slide, at this point, open cover board 310 then after
Continuous pull handle 446, handle will drive restoring board 450 to apply pressure to arc-shaped spring piece, so that arc-shaped spring piece is by buckling
It is relatively moved between shape, that is, side panel 430 and detection block 510, at this point, switch inclined-plane A111 and the first mandril A210
Between relatively move, this just promotes second spring A320 to drive the first mandril mobile to switch inclined-plane A111, the first mandril
Drive the second mandril mobile to switch inclined-plane A111 again, until the second mandril is detached from locking card slot 332, at this point, resetting bullet
Spring 280 drives resetting shaft to move up, and resetting shaft driving supporting plate and folder frame component move up, so that folder frame component ejects detection slot
511, so that folder frame component be facilitated to be removed.
Preferably, two taking-up slots 512 being connected to detection slot can be set at the top of detection block 510, in use, finger
It is very convenient to can be taken off folder frame component across taking-up slot.
Preferably, the height of the locking card slot 332 in the vertical direction is greater than the diameter of the second mandril, this is allowed for
Second mandril can be relatively moved with locking card slot 332.After installing folder frame component, the prominent detection block in folder frame component top surface
Cover board 310 is closed in 510 top surfaces at this time, and the meeting of cover board 310 forms second to detection block and compresses, to guarantee genetic chip and add
Backing is adjacent to.Heating sheet can specifically be referred to using chip controls so as to real-time controller calorific value
Chip heating module disclosed in the Chinese patent of CN103224878A.And the circuit board, genetic chip in this case can also divide
It Can Kao not circuit board, Electrochemistry gene chip disclosed in the Chinese patent of CN103224878A.Certainly, heating sheet, gene core
Piece, circuit board connection type also as above-mentioned patent, genetic chip and circuit board communication connection, circuit board control heating sheet
Temperature change.
Place is not described in detail by the present invention, is the well-known technique of those skilled in the art.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be within the scope of protection determined by the claims.
Claims (10)
1. a kind of detection device, it is characterized in that: including, front panel, rear panel, rear panel are fixed on bottom panel, before described
Panel is fixed by side panel and restoring board assembly；
Rear panel hinged block is provided on the rear panel, the rear panel hinged block passes through on panel articulated shaft and cover board
Cover board hinged block it is hinged；Cover board is for closing at the top of detection slot, and pressing clip frame component, presss from both sides in frame component and is equipped with gene core
Piece；
The folder frame component is mounted in detection slot, and detection slot is arranged on the inside of detection block, and the detection block passes through detection
Bottom plate and bottom panel assembly are fixed, and are provided with supporting plate in the detection slot, below folder frame component, are provided on the supporting plate
Supporting plate through-hole, and assembly is fixed at the top of supporting plate bottom surface and resetting shaft, and location hole is provided at the top of resetting shaft, resets bulge loop, presss from both sides frame
Positioning column assembles after passing through supporting plate through-hole with location hole, fills after circuit board, fixed plate are passed through at the top of the resetting shaft with supporting plate
With fixation；
The resetting shaft bottom is packed into reset guide cylinder, resets the assembly that can slide axially inside bulge loop and reset guide cylinder,
And be adjacent at the top of resetting shaft bottom and reset spring, reset spring bottom is adjacent to detection bottom plate.
2. detection device as described in claim 1, it is characterized in that: rotatably mounted on the fuselage have a clamping lock axis, it is described
Clamping lock axis on be fixed with clamping lock positioning plate, preceding conducting block, the preceding conducting block are installed on the inside of the clamping lock positioning plate
Conduction is contacted with pre-positioning block, so that the first detection circuit is formed into a loop；
One end end face that the detection device is packed into detection mounting groove is rear panel, is led after being provided on the rear panel
Electric block, rear conducting block contacts conduction with the post-positioning block being mounted on the inside of detection mounting groove, so that the second detection circuit shape
At circuit.
3. detection device as described in claim 1, it is characterized in that: the bottom panel bottom is provided with draw runner, the cunning
Item can slide in fuselage sliding slot and supporting plate sliding slot, and the setting of fuselage sliding slot installs trench bottom, and fuselage sliding slot and supporting plate in detection
Sliding slot is interconnected, and supporting plate sliding slot is arranged on fuselage supporting plate.
4. detection device as described in claim 1, it is characterized in that: being additionally provided with cover board observation slot on the cover board, cover board connects
Block, cover board closing piece, the first reagent passage, the second reagent passage are connect, the cover board observation slot is for making optical detection sem observation
Camera lens penetrates, to observe genetic chip.
5. detection device as claimed in claim 4, it is characterized in that: the cover board closing piece is remote with cover board by cover board link block
It is connected from panel articulated shaft one end；The cover board closing piece is compressed by handle, so that cover board is compressed to genetic chip, institute
The handle both ends stated are respectively arranged with handle shaft, and handle shaft is packed into the recessing groove of handle mounting blocks, and the handle turns
Axis can slide in recessing groove, on vertical direction；
Handle shaft one end is pierced by recessing groove, and traversing through end connect axis connection with the closing piece on elastic force closing piece by elastic drawstring and consolidates
Fixed, the elastic drawstring has high resiliency；The handle mounting blocks, elastic force closing piece are fixed on front panel.
6. detection device as claimed in claim 4, it is characterized in that: the first described reagent passage one end and reagent hose connect
The logical, other end is connected to the second reagent passage；
The second reagent passage open end periphery is fixed with the first sealing ring, and first sealing ring is connected to block with reagent
On third reagent passage one end around compress sealing, be provided with the second sealing around the third reagent passage other end
It encloses, sealing is compressed around the reagent wells on second sealing ring and genetic chip.
7. detection device as claimed in claim 4, it is characterized in that: reagent wells, the first reagent passage, the second reagent passage,
There are two three reagent passages are equal, a part flows into the channel of genetic chip as reagent, and another part flows out gene as reagent
The channel of chip.
8. detection device as claimed in claim 4, it is characterized in that: the folder frame component includes the second folder frame, the first folder frame,
Reagent is connected to block setting on the first folder frame, and the first through slot, the first clip slot, strip, folder frame hinged block are additionally provided on the first folder frame,
The strip both ends are respectively arranged with closure card slot；
The observation that first through slot is used to that the first folder frame to be made not block optical detection mirror, first clip slot and gene core
One end face clamping of piece；
The second through slot, the second clip slot, locking card slot, resigning short slot, buckle slot, folder, which are provided with, on the second folder frame confines position
Column, second through slot after so that heating sheet is passed through the second folder frame with genetic chip for being adjacent to, to carry out to genetic chip
Heating；
Second clip slot and the clamping of genetic chip other end, makes it cooperate clamping genetic chip with the first clip slot；
The folder frame hinged block is packed into resigning short slot, and folder frame articulated shaft passes through folder frame hinged block, the second folder frame, so that first
It presss from both sides frame and the second folder frame is hinged
Second clip slot is fixed with card in the buckle slot far from buckle slot is provided on the inside of folder frame articulated shaft one end
It detains, snap fit tabs is provided on the buckle, the snap fit tabs are packed into card slot, thus by the first folder frame and the second folder
Frame is to fixation.
9. a kind of application has the right to require the gene detection equipment of any detection device of 1-8, it is characterized in that: further including bottom
, fuselage is fixed on the pedestal, the fuselage is fixed by fuselage connecting column and fuselage roof assembly, the bottom
It is fixed with fuselage supporting plate on seat, detection mounting groove is provided on the fuselage, detects in mounting groove and detection device is installed, and
Detection end plate is fixed on the detection mounting groove open end, being provided on detection end plate can be with detection device snap-fit
End plate mating groove；Optical detection mirror is fixed between the fuselage top surface and fuselage roof.
10. gene detection equipment as claimed in claim 9, it is characterized in that: further including latch assembly, latch assembly includes, preceding
Panel, side panel are provided with the first flange and the second flange on the side panel, are provided with switch on the detection bottom plate
Sliding slot, second flange are packed into switch sliding slot and slidably assemble therewith, first flange bottom surface and detection block
Clamping forms switch gap between the restoring board and detection block side；
The side panel is provided with switch slot on the side of detection block, switchs and is equipped with switch block in slot, on switch block
It is provided with switch inclined-plane；
Switch inclined-plane is adjacent to first mandril one end, and the first mandril other end is packed into reset hole after passing through stop collar, described
Stop collar is mounted on reset hole one end, and the reset hole other end is connected to slide opening, and the slide opening, reset hole are arranged at detection
On frame side wall；
First mandril, which is packed on one end of reset hole, is provided with card tieholen, and card tieholen closed end and the assembly of the first spring one end are solid
Fixed, one end of the first spring other end and the second mandril loading card tieholen, which is assembled, to be fixed, after the second mandril other end passes through slide opening
With locking card slot snap-fit；
It is further fixed on reset ring on one end that first mandril is packed into reset hole, resets ring and reset hole close to slide opening one
Second spring is provided between the end face at end；
Arc-shaped spring piece is installed, the arc-shaped spring piece arc top part and restoring board assembly are solid in the switch gap
Fixed, both ends are adjacent to detection block.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811079471.0A CN109187475B (en) | 2018-09-17 | 2018-09-17 | Gene chip mounting device and gene detection equipment thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811079471.0A CN109187475B (en) | 2018-09-17 | 2018-09-17 | Gene chip mounting device and gene detection equipment thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109187475A true CN109187475A (en) | 2019-01-11 |
| CN109187475B CN109187475B (en) | 2021-06-04 |
Family
ID=64911299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811079471.0A Active CN109187475B (en) | 2018-09-17 | 2018-09-17 | Gene chip mounting device and gene detection equipment thereof |
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| Country | Link |
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| CN (1) | CN109187475B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110018175A (en) * | 2019-05-25 | 2019-07-16 | 凌龙智能(深圳)科技有限公司 | Automatic checkout equipment |
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|---|---|---|---|---|
| CN103060187A (en) * | 2012-12-31 | 2013-04-24 | 中山大学达安基因股份有限公司 | Detecting device for detecting electrochemical genes |
| CN103224878A (en) * | 2013-05-08 | 2013-07-31 | 中山大学达安基因股份有限公司 | Gene chip based detection apparatus |
| CN205576154U (en) * | 2016-04-06 | 2016-09-14 | 深圳市瀚海基因生物科技有限公司 | Press from both sides dress platform |
| US20180135119A1 (en) * | 2016-04-06 | 2018-05-17 | Direct Genomics Co., Ltd. | Nucleic acid sequencing system |
| CN207762463U (en) * | 2017-12-21 | 2018-08-24 | 深圳华大智造科技有限公司 | Position regulator and gene sequencer equipped with the position regulator |
-
2018
- 2018-09-17 CN CN201811079471.0A patent/CN109187475B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103060187A (en) * | 2012-12-31 | 2013-04-24 | 中山大学达安基因股份有限公司 | Detecting device for detecting electrochemical genes |
| CN103224878A (en) * | 2013-05-08 | 2013-07-31 | 中山大学达安基因股份有限公司 | Gene chip based detection apparatus |
| CN205576154U (en) * | 2016-04-06 | 2016-09-14 | 深圳市瀚海基因生物科技有限公司 | Press from both sides dress platform |
| US20180135119A1 (en) * | 2016-04-06 | 2018-05-17 | Direct Genomics Co., Ltd. | Nucleic acid sequencing system |
| CN207762463U (en) * | 2017-12-21 | 2018-08-24 | 深圳华大智造科技有限公司 | Position regulator and gene sequencer equipped with the position regulator |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110018175A (en) * | 2019-05-25 | 2019-07-16 | 凌龙智能(深圳)科技有限公司 | Automatic checkout equipment |
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| Publication number | Publication date |
|---|---|
| CN109187475B (en) | 2021-06-04 |
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