CN215179656U - POCT blood cell analyzer - Google Patents
POCT blood cell analyzer Download PDFInfo
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- CN215179656U CN215179656U CN202120686481.1U CN202120686481U CN215179656U CN 215179656 U CN215179656 U CN 215179656U CN 202120686481 U CN202120686481 U CN 202120686481U CN 215179656 U CN215179656 U CN 215179656U
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Abstract
The utility model provides a POCT (Point-of-care testing, on-site rapid detection) blood cell analyzer, which comprises a shell, a detection seat and a temperature control module, wherein the detection seat is arranged in the shell and is used for receiving a kit, the temperature control module is arranged in the shell, and the temperature control module is attached to the detection seat to provide detection temperature; the temperature control module is a heating film or a heating rod; and/or the temperature control module is a Peltier, and the Peltier is used for heating or refrigerating the heating seat. Through designing the temperature control module in the POCT blood cell analyzer, the POCT blood cell analyzer is independent of the constant temperature environment of a laboratory, and is convenient to use in the natural environment.
Description
Technical Field
The utility model relates to a blood sample analysis technical field, in particular to POCT blood cell analyzer.
Background
The hemocyte analyzer is called hemocyte analyzer, blood-ball meter, blood-cell counter, etc. and is one of the widely used instruments for clinical examination in hospital.
Most parts of the components in the conventional blood cell analyzer belong to a cleaning system, because the use trace of the previous blood sample must be cleaned before the next blood sample detection. The whole cleaning system is complex in structure and multiple in parts, and a large amount of reagents are needed in the cleaning process, so that the cleaning system occupies a long time.
Compared with the traditional blood cell analyzer, the POCT blood cell analyzer is greatly simplified in instrument components, and the POCT blood cell analyzer can completely remove components related to a cleaning liquid path in the traditional blood analysis, so that the complexity and the production cost of a product are greatly reduced.
However, the conventional POCT blood cell analyzer has a large limitation on the use environment, depends on a constant temperature environment in a laboratory, and is not easily used in a natural environment such as outdoors.
SUMMERY OF THE UTILITY MODEL
The utility model provides a POCT blood cell analyzer can solve and detect among the prior art that service environment restrictive is great, relies on the constant temperature environment in laboratory, is not convenient for the problem of using among natural environment such as open air.
In order to solve the technical problem, the utility model discloses a technical scheme be: provided is a POCT blood cell analyzer including:
a housing;
the detection seat is arranged in the shell and is used for receiving the kit;
the temperature control module is attached to the detection seat to provide detection temperature;
the temperature control module is a heating film or a heating rod; and/or
The temperature control module is a Peltier, and the Peltier is used for heating or refrigerating the heating seat.
The utility model has the advantages that: be different from prior art's condition, the utility model provides a POCT blood cell analyzer is through designing temperature control module in POCT blood cell analyzer, can be so that POCT blood cell analyzer does not rely on the constant temperature environment in laboratory, is convenient for use in natural environment.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
fig. 1 is a schematic perspective view of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 2 is a schematic view of the POCT hematology analyzer receiving kit provided by the embodiment of the present invention;
fig. 3 is a schematic view of an internal structure of a POCT blood cell analyzer according to an embodiment of the present invention;
FIG. 4 is a schematic diagram illustrating a separation state of the reagent kit and the detection seat provided by the embodiment of the present invention;
fig. 5 is an exploded view of a kit according to an embodiment of the present invention;
fig. 6 is a partial cross-sectional view of a kit provided by an embodiment of the present invention;
fig. 7 is a schematic perspective view of a detection seat of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 8 is a schematic cross-sectional structure view of a detection seat of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 9 is a schematic view of an internal structure of a POCT blood cell analyzer according to an embodiment of the present invention;
fig. 10 is a schematic view of a film tearing mechanism provided by an embodiment of the present invention;
fig. 11 is a schematic view of another film tearing mechanism provided in the embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work all belong to the protection scope of the present invention.
It should be noted that, if directional indications (such as upper, lower, left, right, front and rear … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.
Referring to fig. 1 to 11, a POCT blood cell analyzer 10 according to an embodiment of the present invention includes a housing 11, a detection seat 200, a liquid-moving device 300, and a movement mechanism 400.
The housing 11 is provided with a display module 12, a door 13, and a handle 15. The display screen module 12 can be fixedly installed on the upper portion of the side surface of the housing 11, the display screen module 12 can be arranged in an inclined manner so as to be convenient to view, the display screen module 12 can be used for displaying a detection result and performing touch operation, the housing 11 is provided with an opening 14, the door panel 13 is used for covering the opening 14 and can be rotatably connected with the lower portion or the side portion of the housing 11, and the handle portion 15 can be arranged on the top portion of the housing 11 so as to facilitate the portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may also be eliminated, the main control module in the POCT blood cell analyzer 10 is connected to a mobile communication device such as a mobile phone or a tablet computer through a communication method such as bluetooth connection, and the detection result and the corresponding touch operation are displayed through the mobile phone or the tablet computer.
The detection seat 200 is disposed on the casing 11 for receiving the reagent cartridge 100, the detection seat 200 is provided with a plurality of impedance detection components 210 and/or a plurality of optical detection components 220, when the door 13 is opened relative to the casing 11, the detection seat 200 can be moved out of the casing 11 through a sliding component or a hinge component inside the casing 11 to receive the reagent cartridge 100, the impedance detection components 210 have electrode conductive devices 211 (see fig. 8), the electrode conductive devices 211 may specifically be elastic ejector pins (pogo pins), and the electrode conductive devices 211 are electrically connected with the impedance detection cells 120 of the reagent cartridge 100 after the reagent cartridge 100 is installed in the detection seat 200. The detection principle of using the impedance detection module 210 and the optical detection module 220 to perform impedance detection and optical detection on blood cells does not relate to the invention, and is not described in detail in this application. Each impedance detection element 210 and each optical detection element 220 can detect a separate item to obtain a specific blood cell parameter value.
The pipette 300 is disposed in the housing 11 and can be located above the detection seat 200, and is used for sleeving the pipette head 114 (such as tip head) to perform a pipetting operation on the kit 100, the pipetting operation refers to a pipetting, moving and spitting operation, and the pipette 300 can also be used for repeatedly pipetting and spitting liquid to form a pipetting and spitting mixing effect, the pipette 300 provided by the utility model is different from a traditional sampling needle, a sample can enter the inside of the sampling needle when the traditional sampling needle is in the pipetting operation, so as to pollute the inner wall and the outer wall of the sampling needle, and a cleaning operation is required before each detection, the pipette 300 provided by the utility model is sleeved with the pipette head 114, the pipette head 114 has a certain volume, the sample cannot enter the inside of the pipette 300 when the pipetting operation, so as not to pollute the pipette 300, and complex cleaning components and cleaning flows are omitted, the detection efficiency is improved.
The utility model provides a pipettor 300 can include motor, cavity, piston, and the motor is used for driving the piston in the cavity reciprocating motion in order to move the liquid operation.
The utility model provides a pipettor 300 can be ADP (Air drive Pump), and ADP is that the volume is accurate to can produce the power device of malleation and negative pressure.
The traditional blood cell analyzer adopts a set of complex devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application finishes liquid preparation and counting by ADP and does not need cleaning. In addition, the ADP is a modular component, the structure is flexible, the ADP is accurately driven by a motor, and the ADP is slightly interfered by other systems.
The pipette 300 may also be used to bubble the liquid in the kit 100 for the mixing operation, and specifically, when the pipette 300 performs the mixing operation by bubbling, the pipette 300 sucks air above the liquid surface and discharges air below the liquid surface. Of course, also can adopt independent air pressure system to the bottom input air of cell body, corresponding increase extra air pressure system subassembly can, pipettor 300 is used for moving the liquid promptly in this application, still can be used to carry out the bubble mixing, and the subassembly is very simplified.
The movement mechanism 400 is used to move the pipette 300 and the detection seat 200 relative to each other, and the movement mechanism 400 may be a three-axis movement system to drive the pipette 300 to displace in the direction X, Y, Z, of course, the implementation manner of the movement mechanism 400 is not limited thereto, and the movement mechanism 400 may also drive the detection seat 200 to displace relative to the pipette 300 or drive the pipette 300 and the detection seat 200 to displace simultaneously.
In one embodiment, the moving mechanism includes a first motor transmission component 410, a second motor transmission component 420, and a third motor transmission component 430, wherein the first motor transmission component 410 is used for driving the detection seat to move in the X direction; the second motor transmission assembly 420 is used for driving the pipettor to move in the Y direction; the third motor transmission assembly 430 is used for driving the pipettor to move in the Z direction, the first motor transmission assembly 410, the second motor transmission assembly 420, and the third motor transmission assembly 430 may all include a motor 401, a transmission wheel 402, a transmission belt 403, and a transmission member 404, the motor 401 and the transmission wheel 402 are arranged at an interval, the transmission belt 403 is sleeved on the output end of the motor 401 and the transmission wheel 402, the transmission member 404 is fixed with the transmission belt 403 and is in transmission fit with the detection seat 200 or the ADP, for example, the transmission member 404 is provided with a U-shaped bayonet, and the detection seat 200 and the ADP are slidably arranged through a slider and a slide rail mechanism and receive a driving force transmitted from the U-shaped bayonet to perform corresponding sliding.
The embodiment of the utility model provides a POCT blood cell analyzer, with the required supporting part of test system (impedance detection pond 120, optical detection pond 130) and multiple reagent integration on kit 100 to kit 100 belongs to disposable, can remove huge cleaning system, makes the part quantity of whole instrument reduce by a wide margin, and wherein, impedance detection pond 120, optical detection pond 130 are main washing object in traditional blood cell analyzer.
Referring to fig. 4 to 6, the embodiment of the present invention provides a reagent kit 100, where the reagent kit 100 may be a disposable reagent kit or a reusable reagent kit, and the reagent kit 100 includes a kit body 110, a plurality of impedance detection cells 120, a plurality of optical detection cells 130, a reagent cell 140, a kit bottom 150, and a sealing layer 160. The kit 100 has an asymmetric structure, and is convenient to be placed in the detection seat 200 in a foolproof manner.
In one embodiment, the cassette body 110 may be rectangular, and the cassette body 110 may have a first insertion hole 111, where the first insertion hole 111 is used to receive a sample tube 113; alternatively, the cartridge 110 may be directly connected to a sample cell, such as an integral connection or a sleeve connection, and the sample tube 113 may be used to receive a sample, such as a blood sample. The cassette 110 may further be provided with a second insertion hole 112, a first insertion hole 111 for receiving a pipette tip 114, the pipette tip 114 being adapted to be mounted on a pipette 300 for cooperating pipetting operations.
A plurality of impedance detection cells 120 are connected to cartridge 110 for matching impedance detection, and the number of impedance detection cells 120 is at least one, and two are shown in fig. 5.
A plurality of optical detection cells 130 are connected to the box body 110 for performing photoelectric detection, and the number of the optical detection cells 130 is at least one, and two are shown in fig. 5.
The reagent reservoir 140 is connected to the cartridge body 110 for accommodating reagents, such as a hemolytic agent, an antibody reagent, a diluent, and the like. The reagent reservoir 140 may be provided in plural so as to accommodate plural kinds of reagents, and of course, one reagent reservoir 140 may be provided.
The box body 110 is arranged at the opening end of the box bottom 150, and the impedance detection pool 120 and the reagent pool 140 are contained in the box bottom 150; the optical detection cell 130 extends out of the cassette bottom 150; the impedance measuring cell 120, the optical measuring cell 130, and the reagent cell 140 each have an opening 115 communicating with the cartridge 110, and the sealing layer 160 seals and covers the opening 115 (see fig. 10 and 11).
In a specific embodiment, the opening 115 corresponding to the optical detection cell 130 may be a rectangular hole 115a, the opening 115 corresponding to the reagent cell 140 may be a kidney-shaped hole, and includes a large number of small kidney-shaped holes 115b and a large kidney-shaped hole 115c, the reagent cell 140 corresponding to the small kidney-shaped hole 115b may be used to install a plurality of special reagents, such as hemolytic agents and antibody reagents, the reagent cell 140 corresponding to the large kidney-shaped hole 115c may be used to install a diluent and serve as a mixing cell, receive a blood sample and other reagent inputs to support dilution and mixing, the opening 115 corresponding to the impedance detection cell 120 is special, and is a small kidney-shaped hole 115d, the existing impedance detection cell 120 is drained by a negative pressure mode, that is, a liquid in the front cell enters the rear cell by a cell flow mode through the negative pressure acting on the rear cell, an additional negative pressure component is needed for draining by the negative pressure mode, and the application directly uses a 300 pipette to provide positive pressure to the opening 115 of the small kidney-shaped hole 115d so that the front cell provides positive pressure to the front cell The liquid in the chamber 121 enters the rear pool 122 in a cell flow mode, so that negative pressure components can be reduced, and the equipment structure is simplified.
The impedance detection pool 120 is a group or a plurality of groups, the impedance detection pool 120 includes a front pool 121, a rear pool 122 and a detection device 123 for matching impedance detection, the detection device 123 can be an electrode plate, the box bottom 150 is provided with an exposed hole corresponding to the detection device 123 so as to realize that the detection device 123 is electrically connected with an electrode conductive device 211 (see fig. 8) of the impedance detection assembly 210, the electrode conductive device can be an elastic thimble (pogo pin), the impedance detection pool 120 can further include a waste liquid cavity (not shown) communicated with the rear pool 122 for receiving waste liquid, and after positive pressure is provided so that liquid in the front pool 121 enters the rear pool 122 in a cell flow manner, the waste liquid is finally collected by the waste liquid cavity, thereby avoiding waste liquid flowing and scattering.
The optical detection cells 130 are one or more and are adapted to perform a transmitted light photodetection and/or a scattered light photodetection.
The impedance detection cell 120, the optical detection cell 130, and the reagent cell 140 may be integrally formed with the cartridge body 110; or the cartridge body 110 is integrally formed with the assembly cartridge 116, and at least some of the impedance detection cell 120, the optical detection cell 130, and the reagent cell 140 are connected with the assembly cartridge 116 in an abutting manner, such as a snap connection or an interference fit.
The optical detection cell 130 may be made of optical plastic, transparent plastic, or glass.
In one embodiment, the reagent kit 100 is provided with a plurality of cell bodies, which may be arranged in a single row, and correspondingly, the motion mechanism may be a two-dimensional motion mechanism, and drives the ADP to perform reciprocating motion and lifting motion on a two-dimensional plane.
In another embodiment, the reagent kit is provided with a plurality of cell bodies which are arranged in a plurality of rows, and the movement mechanism is a three-dimensional movement mechanism which drives ADP to perform three-dimensional movement in a three-dimensional space.
The utility model provides a kit 100 is through setting up a plurality of impedance detection ponds 120, a plurality of optical detection pond 130 and a plurality of reagent pond 140, can support to carry out impedance detection and/or colorimetric detection and/or than turbid the detection to the blood sample, each optical detection pond 130 and each reagent pond 140 can cooperate and detect an independent project in order to obtain specific blood cell parameter value, the project that its detected is more, and the scalability of detecting the project is good, the preliminary treatment that detects the dilution of sample and add reagent can be allocated through the reagent of preassembleing in the reagent pond 140, POCT detection efficiency has been optimized. In addition, the kit 100 itself can be used as a waste liquid collector, so that a reagent barrel and a waste liquid barrel which are required to be connected with a traditional blood cell analyzer are omitted, and the POCT blood cell analyzer 10 can be portable and movable.
Referring to fig. 1 to 11, an embodiment of the invention provides a POCT blood cell analyzer 10, where the POCT blood cell analyzer 10 includes a housing 11, a support 16, a detection seat 200, a liquid shifter 300, a movement mechanism 400, a storage battery module 500, a power supply module, a temperature control module, and a film tearing mechanism.
The housing 11 is provided with a display module 12, a door 13, and a handle 15. The display screen module 12 can be fixedly installed on the upper portion of the side surface of the casing 11, the display screen module 12 can be obliquely arranged so as to be convenient to view, the display screen module 12 can be used for displaying a detection result and performing touch operation, the casing 11 is provided with an opening 14, the door panel 13 is used for covering the opening 14 and can be rotatably connected with the lower portion or the side portion of the casing 11, the detection seat 200 can be moved out of the casing 11 and receive the reagent kit 100 to be loaded when the door panel 13 is opened, and the handle portion 15 can be arranged on the top of the casing 11 so as to facilitate the portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may also be eliminated, the main control module in the POCT blood cell analyzer 10 is connected to a mobile communication device such as a mobile phone or a tablet computer through a communication method such as bluetooth connection, and the detection result and the corresponding touch operation are displayed through the mobile phone or the tablet computer.
The detection seat 200 is arranged in the shell 11 and is used for receiving the kit 100 to be loaded, wherein the detection seat 200 is arranged in a sliding manner relative to the shell 11, and the detection seat 200 is used for receiving the kit 100 to be loaded when sliding out of the shell 11; alternatively, the test socket 200 is hinged with respect to the housing 11, and the test socket 200 is used for receiving the reagent cartridge 100 when being screwed out of the housing 11.
The detection seat 200 is provided with a plurality of impedance detection components 210 and/or a plurality of optical detection components 220, the impedance detection components 210 include electrode conductive devices 211 (see fig. 8), the electrode conductive devices 211 can be elastic ejector pins (pogo pins), the reagent kit 100 is provided with detection devices 123, the detection devices 123 can be electrode plates, the electrode conductive devices 211 and the detection devices 123 are in electrical contact when the reagent kit 100 is installed in the detection seat 200, and the optical detection components 220 include light emitting components and light receiving components which are arranged at intervals. The detection principle of detecting blood cells by using the impedance detection module 210 and the optical detection module 220 does not relate to the invention, and is not described in detail in this application.
The pipette 300 is disposed in the housing 11 and above the detection seat 200, and is used for sleeving a pipette head 114 (such as a tip head) to perform a pipetting operation on the kit 100. The utility model provides a pipettor 300 can include motor, cavity, piston, and the motor is used for driving the piston in the cavity reciprocating motion in order to move the liquid operation. The utility model provides a pipettor 300 can be ADP (Air drive Pump), and ADP is that the volume is accurate to can produce the power device of malleation and negative pressure. The traditional blood cell analyzer adopts a set of complex devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application finishes liquid preparation and counting by ADP and does not need cleaning. In addition, the ADP is a modular component, the structure is flexible, the ADP is accurately driven by a motor, and the ADP is slightly interfered by other systems.
A carriage 16 is provided within the housing 11 and the ADP is mounted on the carriage 16 by a movement mechanism 400.
Wherein, move liquid operation and refer to imbibition, remove, spit liquid operation, include specifically:
dispensing the blood sample to a specific reagent reservoir 140, which may be pre-filled with a diluent, the specific reagent reservoir 140 may be a reagent reservoir 140 having a large kidney-shaped aperture 115 c;
adding the reagents in the other reagent pools 140 into the specific reagent pool 140 to mix so as to form a sample to be detected, wherein the other reagent pools 140 can be reagent pools 140 with small waist-shaped holes 115 b;
the sample to be detected is moved into the impedance detection cell 120 and/or the optical detection cell 130 for impedance detection and/or optical detection.
The movement mechanism 400 is disposed in the housing 11, and is used for moving the pipette 300 relative to the detection seat 200 to support a pipetting operation, and the movement mechanism 400 may be a three-axis movement system to drive the pipette 300 to displace in the direction X, Y, Z, of course, the implementation manner of the movement mechanism 400 is not limited thereto, and the movement mechanism 400 may also drive the detection seat 200 to displace relative to the pipette 300 or drive the pipette 300 and the detection seat 200 to displace simultaneously.
The battery module 500 is electrically connected to the test socket 200, the movement mechanism 400, and the pipette 300, and the POCT blood cell analyzer 10 can be conveniently used in various places, for example, outdoors, by providing the battery module 500. In order to facilitate the assembly and disassembly of the battery module 500, a battery cavity may be disposed on the outer surface of the housing 11, and the battery module 500 and the battery cavity are assembled by a snap fit, or the POCT blood cell analyzer is provided with a battery cavity and a cover plate, the battery module and the battery cavity are assembled by a snap fit and are covered by the cover plate, the cover plate may be an instrument housing, or may be a panel on any side surface or top end of the instrument, and the two ways may both achieve the convenient assembly and disassembly of the battery module 500. Certainly, the POCT blood cell analyzer 10 further includes a power supply module electrically connected to the detection seat 200, the movement mechanism 400 and the pipette 300, and configured to connect to a mains supply.
The temperature control module is attached to the detection base 200 to provide a detection temperature. As shown in fig. 7, the temperature control module may be a heating film 510 attached to the bottom surface or the side surface of the detection seat 200, or the temperature control module may be a heating rod, and accordingly, the detection seat 200 is provided with a mounting hole for receiving the heating rod; the temperature control module can also be a peltier 520, and the peltier 520 is used for heating or cooling the heating base. Current POCT hematology analyzer relies on the constant temperature environment in laboratory, is not convenient for use in natural environment, the utility model provides a POCT hematology analyzer can independently heat or refrigerate through setting up temperature control module, and ambient temperature is little to detecting the influence.
In one embodiment, the pipette 300 includes a motor, a cavity, and a piston, wherein the motor is used to drive the piston to reciprocate in the cavity to perform pipetting operations.
The film tearing mechanism is used for tearing the sealing layer 160 on the surface of the kit 100; or a peel mechanism for puncturing the sealing layer 160 on the surface of the kit 100.
As shown in fig. 10, the film tearing mechanism may be a fixedly arranged hook 610, the hook 610 is used for hooking the tab portion 162 of the sealing layer 160 when the detection seat 200 receives the reagent kit 100 and enters the housing 11, so as to realize automatic film tearing, the hook 610 may be in an L-shaped plate, and the tab portion 162 is provided with a corresponding hook hole. If a manual film tearing mode is adopted, namely the reagent kit 100 is arranged in the detection seat 200 after the sealing layer 160 is torn off, due to the uncertainty of operation, the reagent pre-arranged in the reagent kit 100 is easily spilled, so that the normal detection is influenced due to the insufficient amount of the reagent.
As shown in fig. 11, in another embodiment, the film tearing mechanism includes a plate 621, a film breaking column 622 disposed on one surface of the plate 621, and a driving mechanism 623 for driving the plate 621 to ascend and descend, the film breaking column 621 corresponds to the cell body of the reagent kit 100, the driving mechanism 623 is configured to drive the plate 621 so that the film breaking column 622 pierces the sealing layer 160 on the surface of the reagent kit 100, a free end of the film breaking column 622 has a gradually decreasing cross-sectional area, the film breaking column 622 may be in a conical shape, and the driving mechanism 623 may be a motor and a transmission belt or a motor and gear transmission mechanism.
The embodiment of the utility model provides a still provide a detection method based on aforementioned POCT blood cell analyzer 10, this method includes:
receiving the reagent kit 100 and putting the reagent kit 100 into the detection seat 200, wherein the reagent kit 100 comprises a plurality of impedance detection cells 120 and/or a plurality of optical detection cells 130 which are used for matching impedance and/or photoelectric detection, the reagent kit 100 further comprises a plurality of reagent cells 140, the reagent cells 140 are used for containing a plurality of reagents, the reagent kit 100 is further provided with a sample tube, and a blood sample is filled in the sample tube;
dispensing a blood sample into a specific reagent reservoir 140 by a pipette 300, i.e. automatic blood dispensing by a device;
adding the reagents in other reagent pools 140 into the specific reagent pool 140 through the pipettor 300 for mixing to form a sample to be detected, namely, automatically adding the reagents through equipment;
the sample to be detected is moved into the impedance detection cell 120 and/or the optical detection cell 130 by the pipette 300 to perform impedance detection and/or optical detection.
The utility model provides a POCT blood cell analyzer and detection method can realize automatic distribution blood sample, automatic reagent that adds through the cooperation of motion mechanism, pipettor, has optimized POCT detection efficiency. In the existing detection method, reagents are required to be added manually, and the reagents are poured into an instrument for detection after being mixed manually.
Wherein, the step of receiving the reagent kit 100 into the test seat 200 comprises the following steps:
tearing the sealing layer 160 on the surface of the kit 100 by using a film tearing mechanism; or a tear mechanism may be used to puncture the sealing layer 160 on the surface of the kit 100.
Wherein the step of dispensing the blood sample into the specific reagent reservoir 140 by the pipette 300 is preceded by:
the pipette 300 is inserted and butted with a pipette tip 114 preset on the kit 100, so that the blood sample, the reagent and the sample to be detected are contacted only through the pipette tip 114 when the pipette 300 performs the pipetting operation, and the pipette 300 is prevented from being polluted.
Wherein, utilize pipettor 300 to provide the malleation in order to impel the sample that awaits measuring in the impedance detection pond to flow when carrying out the impedance detection, can reduce among the prior art need extra negative pressure device to carry out the impedance detection drainage through multiplexing pipettor 300, reduced the product subassembly.
According to the POCT blood cell analyzer and the detection method provided by the embodiment, automatic blood sample distribution and automatic reagent addition can be realized through the cooperation of the movement mechanism and the pipettor, and the POCT detection efficiency is optimized.
The embodiment of the utility model provides a still provide a drive arrangement that the liquid of impedance detection pond 120 flows, this drive arrangement includes the pressure source, and impedance detection pond 120 includes forebay 121, back pond 122 through the micropore intercommunication and is used for the cooperation to carry out the detection device 123 that the impedance detected, and the pressure source is used for exerting pressure to forebay 121 and makes the liquid in the forebay 121 flow to back pond 122 through the micropore.
The pressure source may be embodied as a pipette 300, the pipette 300 being configured for pipetting when the pipette head 114 is docked and the pipette 300 being further configured for applying pressure when the pipette head 114 is undocked. The utility model provides a pipettor 300 can be ADP (Air drive Pump), and ADP is that the volume is accurate to can produce the power device of malleation and negative pressure. The traditional blood cell analyzer adopts a set of complex devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application finishes liquid preparation and counting by ADP and does not need cleaning. In addition, the ADP is a modular component, and has a flexible architecture and is less interfered by other systems.
The pipette 300 includes a motor, a cavity, and a piston, and the motor is used to drive the piston to reciprocate in the cavity to perform pipetting operations.
The top end of forebay 121 is provided with an opening 115, and opening 115 is used for close-fitting docking with the free end of pipette 300 to receive pressure input into forebay 121. The opening 115 may be in the shape of a small circular hole 115d to facilitate a tight fit with the free end of the pipette 300.
The embodiment of the utility model provides a POCT blood cell analyzer is still provided, this blood analyzer includes casing 11, detects seat 200, pressure source, motion 400, temperature control module, battery module 50, power module.
The housing 11 is provided with a display module 12, a door 13, and a handle 15. The display screen module 12 can be fixedly installed on the upper portion of the side surface of the casing 11, the display screen module 12 can be obliquely arranged so as to be convenient to view, the display screen module 12 can be used for displaying a detection result and performing touch operation, the casing 11 is provided with an opening 14, the door panel 13 is used for covering the opening 14 and can be rotatably connected with the lower portion of the casing 11, the detection seat 200 can be moved out of the casing 11 and receive the reagent kit 100 to be loaded when the door panel 13 is opened, and the lifting handle 15 can be arranged on the top of the casing 11 so as to facilitate the portable movement of the POCT blood cell analyzer 10. Of course, the display screen module 12 may also be eliminated, the main control module in the POCT blood cell analyzer 10 is connected to a mobile communication device such as a mobile phone or a tablet computer through a communication method such as bluetooth connection, and the detection result and the corresponding touch operation are displayed through the mobile phone or the tablet computer.
The detection seat 200 is arranged in the shell 11 and used for receiving the reagent kit 100, the reagent kit 100 comprises an impedance detection cell 120, the impedance detection cell 120 comprises a front cell 121 and a rear cell 122 which are communicated through micropores and a detection device 123 used for matching to perform impedance detection, the detection seat 200 is provided with an impedance detection assembly 210 corresponding to the impedance detection cell 120, the impedance detection assembly 210 comprises an electrode conductive device 211, and the electrode conductive device 211 is electrically contacted with the detection device 123 when the reagent kit 100 is arranged in the detection seat 200.
A pressure source is disposed within the housing 11 for applying pressure to the front reservoir 121 to cause liquid in the front reservoir 121 to flow through the pores to the back reservoir 122. The pressure source may be embodied as a pipette 300, the pipette 300 being configured for pipetting when the pipette head 114 is docked and the pipette 300 being further configured for applying pressure when the pipette head 114 is undocked. The utility model provides a pipettor 300 can be ADP (Air drive Pump), and ADP is that the volume is accurate to can produce the power device of malleation and negative pressure. The traditional blood cell analyzer adopts a set of complex devices such as an air pump, an air valve, a pressure chamber and the like to realize liquid preparation, counting and cleaning. The POCT blood cell analyzer provided by the application finishes liquid preparation and counting by ADP and does not need cleaning. In addition, the ADP is a modular component, and has a flexible architecture and is less interfered by other systems.
The liquid transfer device 300 comprises a motor, a cavity and a piston, wherein the motor is used for driving the piston to reciprocate in the cavity so as to perform liquid transfer operation, sucking and spitting mixing operation or inflating and mixing.
As shown in fig. 5, the top end of forebay 121 is provided with an opening 115, and opening 115 is adapted to mate with the free end of pipette 300 to receive pressure input into forebay 121. The opening 115 may be in the shape of a small circular hole 115d to facilitate a tight fit with the free end of the pipette 300.
In particular embodiments, the pipette 300 may include a first syringe and a second syringe slidably nested, with the free end of the second syringe retracted into the free end of the first syringe such that the free end of the first syringe is exposed and thereby received by the pipette head 114, and the second syringe separated from the pipette head 114 when moved toward the free end of the first syringe.
The movement mechanism 400 is disposed in the housing 11, and is used for moving the pipette 300 relative to the detection seat 200 to perform a pipette holding operation; the temperature control module is attached to the detection seat 200 to provide a detection temperature; the battery module 500 is electrically connected to the detection holder 200, the movement mechanism 400, and the pipette 300; and/or the power supply module is electrically connected with the detection seat 200, the movement mechanism 400 and the pipette 300, and is used for connecting with the mains supply.
The embodiment of the utility model provides a POCT hematology analyzer and impedance detect drive arrangement that liquid flows in pond makes the liquid in the fore-pool through micropore flow direction rear pool through applying pressure to the pond forward, need not extra negative pressure generating device, can simplify the product subassembly structure.
The above is only the embodiment of the present invention, not the limitation of the patent scope of the present invention, all the equivalent structures or equivalent processes that are used in the specification and the attached drawings or directly or indirectly applied to other related technical fields are included in the patent protection scope of the present invention.
Claims (10)
1. A POCT blood cell analyzer, comprising:
a housing;
the detection seat is arranged in the shell and is used for receiving the kit;
and the temperature control module is attached to the detection seat so as to provide detection temperature.
2. The POCT hematology analyzer of claim 1, wherein:
the temperature control module is a heating film or a heating rod; and/or
The temperature control module is a Peltier, and the Peltier is used for heating or refrigerating the heating seat.
3. The POCT hematology analyzer of claim 1, further comprising:
the pipettor is arranged in the shell and used for carrying out pipetting operation on the kit;
and the movement mechanism is arranged in the shell and is used for enabling the pipettor to move relative to the detection seat so as to support the pipetting operation.
4. The POCT hematology analyzer of claim 3, wherein:
the POCT blood cell analyzer also comprises a storage battery module which is electrically connected with the detection seat, the temperature control module, the motion mechanism and the pipettor; and/or;
the POCT blood cell analyzer further comprises a power supply module, wherein the power supply module is electrically connected with the detection seat, the temperature control module, the movement mechanism and the pipettor and is used for being connected with a mains supply.
5. The POCT hematology analyzer of claim 4, wherein:
a battery cavity is formed in the outer surface of the shell, and the storage battery module is assembled with the battery cavity in a buckling mode; or
The POCT blood cell analyzer is provided with a battery cavity and a cover plate, and the storage battery module is assembled with the battery cavity in a buckling mode and is covered by the cover plate in a sealing mode.
6. The POCT hematology analyzer of claim 1, wherein:
the POCT blood cell analyzer further comprises a door plate, the shell is provided with an opening, the door plate is used for opening or closing the opening, and when the door plate is opened, the detection seat can slide out of the shell and receive the kit to be loaded.
7. The POCT hematology analyzer of claim 3, wherein:
the pipettor comprises a motor, a cavity and a piston, wherein the motor is used for driving the piston to reciprocate in the cavity so as to perform pipetting operation.
8. The POCT hematology analyzer of claim 3, wherein:
the pipette is further used to provide positive pressure to cause liquid flow within an impedance detection well of the kit; and/or
The pipettor is also used for sucking and spitting to realize uniform mixing operation; and/or
The liquid transfer device is also used for inflating bubbles into liquid so as to realize uniform mixing operation.
9. The POCT hematology analyzer of claim 1, wherein:
the POCT blood cell analyzer also comprises a film tearing mechanism;
the film tearing mechanism is used for tearing the sealing layer on the surface of the kit; or
The film tearing mechanism is used for puncturing a sealing layer on the surface of the kit.
10. The POCT blood cell analyzer of claim 9, wherein:
the film tearing mechanism is a hook-hanging piece which is used for hooking a lug piece part of the sealing layer when the detection seat receives the reagent kit and then enters the shell; or
The film tearing mechanism comprises a plate body, a plurality of film breaking columns arranged on one surface of the plate body in an array mode and a driving mechanism used for driving the plate body to lift, wherein the driving mechanism is used for driving the plate body to enable the film breaking columns to puncture a sealing layer on the surface of the kit.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020204870404 | 2020-04-03 | ||
| CN202020487040 | 2020-04-03 |
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| Publication Number | Publication Date |
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| CN215179656U true CN215179656U (en) | 2021-12-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114397335A (en) * | 2022-01-18 | 2022-04-26 | 海南德名声科技有限责任公司 | Novel blood gas analyzer measuring chamber |
| WO2023134622A1 (en) * | 2022-01-11 | 2023-07-20 | Guangzhou Wondfo Biotech Co., Ltd. | Blood gas analyzer |
-
2021
- 2021-04-02 CN CN202120686481.1U patent/CN215179656U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023134622A1 (en) * | 2022-01-11 | 2023-07-20 | Guangzhou Wondfo Biotech Co., Ltd. | Blood gas analyzer |
| CN114397335A (en) * | 2022-01-18 | 2022-04-26 | 海南德名声科技有限责任公司 | Novel blood gas analyzer measuring chamber |
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