CN205576154U - Press from both sides dress platform - Google Patents
Press from both sides dress platform Download PDFInfo
- Publication number
- CN205576154U CN205576154U CN201620278940.1U CN201620278940U CN205576154U CN 205576154 U CN205576154 U CN 205576154U CN 201620278940 U CN201620278940 U CN 201620278940U CN 205576154 U CN205576154 U CN 205576154U
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- platform
- clamp
- limit
- frame
- gene sequencing
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- 108090000623 proteins and genes Proteins 0.000 claims abstract description 48
- 238000012163 sequencing technique Methods 0.000 claims abstract description 46
- 230000007306 turnover Effects 0.000 claims abstract description 12
- 238000009434 installation Methods 0.000 claims abstract description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 238000005516 engineering process Methods 0.000 description 6
- 238000003752 polymerase chain reaction Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007622 bioinformatic analysis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000012165 high-throughput sequencing Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a press from both sides dress platform belongs to the technical scheme in the gene sequencing field, and it includes that the platform base fixes a position the fixed dress frame that presss from both sides with being used for to gene sequencing chip, press from both sides the dress frame with platform base pivot hookup, so that it can turn over to leaving with turning over to press from both sides the dress frame the platform base, a serial communication port, the upper surface of platform base is equipped with and is used for the installation gene sequencing chip's installing zone, install the control by temperature change chip in the installing zone. Because in the installing zone is located to the control by temperature change chip, thus the control by temperature change chip can with gene sequencing chip direct contact for efficiency of heat transfer, the control by temperature change chip has the temperature control accuracy, adjusts rapid characteristics moreover, thus solved prior art temperature control exist lag behind, unsafe problem.
Description
Technical field
This utility model relates to the parts of a kind of gene sequencing equipment, clamps platform particularly to one.
Background technology
Along with the development of gene sequencing technology, second filial generation high throughput sequencing technologies has been widely used for
In each research field, but along with the popularization of application, the weak point of secondary order-checking highlights the most day by day.Such as,
Needing library construction, process is not only complicated but also the most long；Need to carry out PCR amplification, easily produce partially
Good property, causes the distortion of original gene ratio；Sequencing reading length is shorter, to follow-up sequence assembly and assembling etc.
Bioinformatic analysis brings difficulty.Therefore third generation single-molecule sequencing technology is arisen at the historic moment, and it uses single point
Sub-reading technology, has higher sensitivity and faster data reading speed, without the need for PCR
(Polymerase Chain Reaction) expands, it is ensured that the real information of detection sample, the most further
Reduce order-checking cost.Wherein, PCR cries again polymerase chain reaction, and polymerase chain reaction is a kind of using
In amplifying the Protocols in Molecular Biology expanding specific DNA fragmentation, it is considered as the special DNA of in vitro
Replicating, the maximum feature of PCR, is to be significantly increased by the DNA of trace.
Wherein, above-mentioned third generation single-molecule sequencing technology is applied to need to keep reaction temperature accurate, in existing skill
In art, gene sequencing chip is arranged on and clamps on platform, and the bottom clamping platform is provided with heater strip, heater strip
Directly do not contact with gene sequencing chip；But owing to the thermal inertia of heater strip is relatively big, the regulation to temperature has
There is bigger hysteresis quality, thus bring bad impact for gene sequencing.
Utility model content
The purpose of this utility model is to provide one to clamp platform, inaccurate to solve the control of prior art temperature
True problem.
In order to solve above-mentioned technical problem, this utility model provides one and clamps platform, including platform base
With for clamping frame to what gene sequencing chip was fixed on the positioning, described in clamp frame and turn with described platform base
Axle couple so that described in clamp frame can turn over to turn over from described platform base, the upper table of described platform base
Face is provided with the installing zone for installing described gene sequencing chip, is provided with Temperature Controlling Chip in described installing zone.
Preferably, the both sides of described installing zone are equipped with reagent pod apertures, the upper port of described reagent pod apertures
For connecting with described gene sequencing chip.
Preferably, described platform base is respectively provided with a rotating shaft platform in the both sides of described installing zone；
The described frame that clamps includes that two clamp limit and limit, a location, described two one end clamping limit respectively with
The two ends on limit, described location are vertically connected and connect, and described two other ends clamping limit turn with described rotating shaft platform respectively
Axle couples so that described in clamp frame and turn over when described platform base, described in clamp frame and can be centered around described installation
The periphery in district.
Preferably, limit, described location is provided with snap close, described base platform with corresponding position, described snap close position
Being provided with lock station, described lock station is provided with unblock button；
Described snap close is used for inserting in described lock station, with this realize clamping between frame and base platform sealed fixed
Position；
The described frame that clamps is fixed by described unblock button for releasing described lock station.
Preferably, clamp limit described in and can be provided with boss, described boss use towards the surface of described platform base
In in embedding described gene sequencing chip, it being positioned.
Preferably, clamp limit described in and described rotating shaft platform connection place is provided with torsion spring, one end of described torsion spring and institute
State and clamp that limit abuts, the other end abuts with described rotating shaft platform, with this make described in clamp frame and be maintained at and open shape
State.
The beneficial effects of the utility model are as follows:
Temperature Controlling Chip is located in installing zone, so Temperature Controlling Chip directly can contact with gene sequencing chip, adds
Fast heat transference efficiency；And Temperature Controlling Chip has temperature precise control, regulates rapid feature, thus solve
Prior art of having determined temperature controls to there is problem delayed, inaccurate.
Accompanying drawing explanation
In order to be illustrated more clearly that the technical solution of the utility model, will make required in embodiment below
Accompanying drawing be briefly described, it should be apparent that, below describe in accompanying drawing the most of the present utility model
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 be this utility model preferred embodiment provide clamp beating when gene sequencing chip do not installed by platform
Open state schematic diagram；
Fig. 2 is the part A enlarged diagram of Fig. 1；
Fig. 3 be this utility model preferred embodiment provide clamp pass when gene sequencing chip do not installed by platform
Closed state schematic diagram；
Fig. 4 be this utility model preferred embodiment provide clamp stage+module gene sequencing chip after open
View；
Fig. 5 is the closedown clamped after stage+module gene sequencing chip that this utility model preferred embodiment provides
View；
Fig. 6 is the diagrammatic side-view cross-sectional schematic diagram clamping platform that this utility model preferred embodiment provides；
Fig. 7 is the gene sequencing chip structure schematic diagram that this utility model preferred embodiment provides.
Reference is as follows:
2, platform is clamped；21, platform base；211, installing zone；212, reagent pod apertures；213, turn
Pillow block；214, lock station；215, button is unlocked；22, Temperature Controlling Chip；23, frame is clamped；231, limit is clamped；
232, limit, location；233, snap close；234, boss；24, torsion spring；6, gene sequencing chip；61, fixed
Hole, position；62, the first gene sequencing passage；63, the second gene sequencing passage.
Detailed description of the invention
Below in conjunction with the accompanying drawing in this utility model embodiment, to the skill in this utility model embodiment
Art scheme is clearly and completely described.
Knowable to Fig. 1 is to 7, the platform 2 that clamps described in the utility model includes platform base 21 and for right
What gene sequencing chip was fixed on the positioning clamps frame 23, described in clamp frame 23 and described platform base 21 turns
Axle couple so that described in clamp frame 23 can turn over to turn over from described platform base 21, described platform base
The upper surface of 21 is provided with the installing zone 211 for installing described gene sequencing chip, in described installing zone 211
Temperature Controlling Chip 22 is installed.
When clamping frame 23 and turning over from platform base 21, gene sequencing chip just can be arranged on installing zone 211
In, or gene sequencing chip is removed in installing zone 211；When gene sequencing chip is arranged on installing zone
After 211, just can turn over clamping frame 23 to platform base 21, with this, gene sequencing chip be carried out folder and consolidate calmly；
And the technical program uses Temperature Controlling Chip 22 to control the reaction temperature in gene sequencing chip, its temperature controls
Accurately, easy to adjust, this be prior art use electric-heating-wire-heating cannot realize.
Further, as it is shown in figure 1, the both sides of described installing zone 211 are equipped with reagent pod apertures 212,
The upper port of described reagent pod apertures 212 is for connecting with described gene sequencing chip.When this utility model should
Time on gene sequencer, the lower port of reagent pod apertures 212 is then for connecting with fluid control device.
Further, as it is shown in figure 1, described platform base 21 respectively sets in the both sides of described installing zone 211
There is a rotating shaft platform 213；The described frame 23 that clamps includes that two clamp limit 231 and limit 232, a location, institute
State the two ends respectively with limit, described location 232, two one end clamping limit 231 to be vertically connected and connect, described two
The other end clamping limit 231 couples with the rotating shaft of described rotating shaft platform 213 respectively so that described in clamp frame 23 turn over to
During described platform base 21, described in clamp frame 23 and can be centered around the periphery of described installing zone 211.
Further, as it is shown in figure 1, limit, described location 232 is provided with snap close 233, described base platform
Being provided with lock station 214 with corresponding position, described snap close 233 position, described lock station 214 is provided with unblock button 215；
Described snap close 233 is used for inserting in described lock station 214, realizes clamping between frame 23 and base platform with this
Sealed location；Described unblock button 215 clamps the fixing of frame 23 for releasing described lock station 214 to described.
Further, as shown in figs. 1 and 4, clamping limit 231 described in can be towards described platform base 21
Surface be provided with boss 234, described boss 234 is for positioning it in embedding described gene sequencing chip 6.
Wherein, the both sides of the most described gene sequencing chip 6 are equipped with hole 61, location, and described boss 234 is used for
To in embedding hole, described location 61, described gene sequencing chip 6 is positioned.
Further, as in figure 2 it is shown, described in clamp limit 231 and be provided with described rotating shaft platform 213 connection place
Torsion spring 24, one end of described torsion spring 24 with described clamp limit 231 abut, the other end and described rotating shaft platform 213
Abut, with this make described in clamp frame 23 and be maintained at the state of opening.
As it is shown in figure 1, in normal state, owing to torsion spring 24 persistently exerts a force to clamping limit 231, so folder
Frame up and 23 will remain in the state of opening, turn over to platform base 21 if frame 23 now will be clamped, then snap close 233
To embed in lock station 214, so that clamp frame 23 can be centered around the periphery of installing zone 211, and with this shape
State keeps fixing, the most as shown in Figure 3；And after pressing unblock button 215, lock station 214 is to snap close 233
Unlock, thus torsion spring 24 again will clamp frame 23 and push away platform base 21, the most just can be surveyed by gene
Sequence chip 6 is arranged in installing zone 211, and the state after installation is as shown in Figure 4；Finally, as long as will clamp
Frame 23 turns over to platform base 21, makes snap close 233 just will can enter gene sequencing chip 6 in embedding lock station 214
Row is fixing, and wherein, described boss 234 will embed in hole, described location 61, with this further enchancer
Sequence testing chip fixing, concrete visible Fig. 5 and Fig. 6, now gene sequencing chip 6, Temperature Controlling Chip 22, flat
Platform base 21 and mobile platform 5 will be arranged the most from top to bottom.
It addition, as it is shown in fig. 7, described gene sequencing chip 6 is provided with the first gene sequencing passage 62 and
Two gene order-checking passage 63, after gene sequencing chip 6 is arranged on installing zone 211, described first gene is surveyed
Sequence passage 62 and the second gene sequencing passage 63 connect and are connected with reagent pod apertures.
The above is preferred implementation of the present utility model, it is noted that general for the art
For logical technical staff, on the premise of without departing from this utility model principle, it is also possible to make some improvement and
Retouching, these improvements and modifications are also considered as protection domain of the present utility model.
Claims (6)
1. clamp a platform, including platform base with for clamping that gene sequencing chip is fixed on the positioning
Frame, described in clamp frame and couple with described platform base rotating shaft so that described in clamp frame can turn over to turn over from institute
State platform base, it is characterised in that the upper surface of described platform base is provided with for installing described gene sequencing
The installing zone of chip, is provided with Temperature Controlling Chip in described installing zone.
The most according to claim 1 clamp platform, it is characterised in that the both sides of described installing zone are equipped with
Reagent pod apertures, the upper port of described reagent pod apertures is for connecting with described gene sequencing chip.
The most according to claim 1 clamp platform, it is characterised in that
Described platform base is respectively provided with a rotating shaft platform in the both sides of described installing zone；
The described frame that clamps includes that two clamp limit and limit, a location, described two one end clamping limit respectively with
The two ends on limit, described location are vertically connected and connect, and described two other ends clamping limit turn with described rotating shaft platform respectively
Axle couples so that described in clamp frame and turn over when described platform base, described in clamp frame and can be centered around described installation
The periphery in district.
The most according to claim 3 clamp platform, it is characterised in that
Limit, described location is provided with snap close, and described base platform is being provided with lock station with corresponding position, described snap close position,
Described lock station is provided with unblock button；
Described snap close is used for inserting in described lock station, with this realize clamping between frame and base platform sealed fixed
Position；
The described frame that clamps is fixed by described unblock button for releasing described lock station.
The most according to claim 3 clamp platform, it is characterised in that described in clamp limit can be towards described
The surface of platform base is provided with boss, and described boss is for positioning it in embedding described gene sequencing chip.
The most according to claim 3 clamp platform, it is characterised in that described in clamp limit and described rotating shaft platform
Connection place is provided with torsion spring, with described, one end of described torsion spring clamps that limit abuts, the other end supports with described rotating shaft platform
Connect, with this make described in clamp frame and be maintained at the state of opening.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620278940.1U CN205576154U (en) | 2016-04-06 | 2016-04-06 | Press from both sides dress platform |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620278940.1U CN205576154U (en) | 2016-04-06 | 2016-04-06 | Press from both sides dress platform |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205576154U true CN205576154U (en) | 2016-09-14 |
Family
ID=56865040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620278940.1U Active CN205576154U (en) | 2016-04-06 | 2016-04-06 | Press from both sides dress platform |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205576154U (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106770114A (en) * | 2016-12-23 | 2017-05-31 | 西安交通大学 | A kind of high-flux sequence base fluorescence identifying system and device and method |
| WO2018113435A1 (en) * | 2016-12-21 | 2018-06-28 | 深圳市瀚海基因生物科技有限公司 | Sample bearing system |
| CN108265003A (en) * | 2016-12-30 | 2018-07-10 | 广州康昕瑞基因健康科技有限公司 | Multichannel gene sequencing reaction cell and multichannel gene sequencing reaction device |
| CN108326773A (en) * | 2018-01-08 | 2018-07-27 | 清华大学 | A kind of chip fixture apparatus |
| CN108326774A (en) * | 2018-01-08 | 2018-07-27 | 清华大学 | A kind of chip fixture apparatus |
| CN109187475A (en) * | 2018-09-17 | 2019-01-11 | 赵勇 | A kind of detection device and its gene detection equipment |
| WO2020034143A1 (en) * | 2018-08-16 | 2020-02-20 | 深圳华大智造科技有限公司 | Handle device, positioning device, loading device and gene sequencer |
| CN110846202A (en) * | 2019-10-30 | 2020-02-28 | 广州市金圻睿生物科技有限责任公司 | Accurate positioning clamping sample adding platform device of gene sequencing chip and gene sequencer |
| CN110892057A (en) * | 2017-08-01 | 2020-03-17 | 深圳华大智造科技有限公司 | Gene sequencing reaction apparatus, gene sequencing system, and gene sequencing reaction method |
| US20220016633A1 (en) * | 2018-12-13 | 2022-01-20 | Mgi Tech Co., Ltd. | Portable sample loading device |
| US12121902B2 (en) * | 2018-12-13 | 2024-10-22 | Mgi Tech Co., Ltd. | Portable sample loading device |
-
2016
- 2016-04-06 CN CN201620278940.1U patent/CN205576154U/en active Active
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018113435A1 (en) * | 2016-12-21 | 2018-06-28 | 深圳市瀚海基因生物科技有限公司 | Sample bearing system |
| CN106770114A (en) * | 2016-12-23 | 2017-05-31 | 西安交通大学 | A kind of high-flux sequence base fluorescence identifying system and device and method |
| CN108265003A (en) * | 2016-12-30 | 2018-07-10 | 广州康昕瑞基因健康科技有限公司 | Multichannel gene sequencing reaction cell and multichannel gene sequencing reaction device |
| CN110892057A (en) * | 2017-08-01 | 2020-03-17 | 深圳华大智造科技有限公司 | Gene sequencing reaction apparatus, gene sequencing system, and gene sequencing reaction method |
| CN108326773A (en) * | 2018-01-08 | 2018-07-27 | 清华大学 | A kind of chip fixture apparatus |
| CN108326774A (en) * | 2018-01-08 | 2018-07-27 | 清华大学 | A kind of chip fixture apparatus |
| CN108326774B (en) * | 2018-01-08 | 2024-08-02 | 清华大学 | Chip fixing device |
| CN108326773B (en) * | 2018-01-08 | 2024-08-02 | 清华大学 | Chip fixing device |
| WO2020034143A1 (en) * | 2018-08-16 | 2020-02-20 | 深圳华大智造科技有限公司 | Handle device, positioning device, loading device and gene sequencer |
| CN109187475B (en) * | 2018-09-17 | 2021-06-04 | 赵勇 | Gene chip mounting device and gene detection equipment thereof |
| CN109187475A (en) * | 2018-09-17 | 2019-01-11 | 赵勇 | A kind of detection device and its gene detection equipment |
| US20220016633A1 (en) * | 2018-12-13 | 2022-01-20 | Mgi Tech Co., Ltd. | Portable sample loading device |
| US12121902B2 (en) * | 2018-12-13 | 2024-10-22 | Mgi Tech Co., Ltd. | Portable sample loading device |
| CN110846202B (en) * | 2019-10-30 | 2022-12-06 | 广州市金圻睿生物科技有限责任公司 | Accurate positioning clamping sample adding platform device of gene sequencing chip and gene sequencer |
| CN110846202A (en) * | 2019-10-30 | 2020-02-28 | 广州市金圻睿生物科技有限责任公司 | Accurate positioning clamping sample adding platform device of gene sequencing chip and gene sequencer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 518000 Shenye Jinyuan Building, No. 116 Qingshuihe Road, Qingshuihe Street, Luohu District, Shenzhen City, Guangdong Province, 2 5th and 6th floors Patentee after: Shenzhen Zhenmai Biotechnology Co.,Ltd. Address before: The city on the 518000 Shenzhen Road, Guangdong province Nanshan District Xili Xili Street University No. 9 National Supercomputing research center 10 floor building in Shenzhen Patentee before: DIRECT GENOMICS Co.,Ltd. |
|
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 518000 podium 502A and 502B, podium 602, Luohu investment holding building, No. 112, Qingshuihe 1st Road, Qingshuihe community, Qingshuihe street, Luohu District, Shenzhen, Guangdong Patentee after: Shenzhen Zhenmai Biotechnology Co.,Ltd. Country or region after: China Address before: 518000 5th and 6th floors, block 2, Shenye Jinyuan Building, No.116, Qingshuihe 1st Road, Qingshuihe street, Luohu District, Shenzhen City, Guangdong Province Patentee before: Shenzhen Zhenmai Biotechnology Co.,Ltd. Country or region before: China |