CN109172810A - 一种防治头颈癌的生物组合物 - Google Patents
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Abstract
本发明涉及一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物8~12份、玉米肽5~8份、黄精提取物2~5份、嗜酸乳杆菌3~6份、茯苓多糖6~10份、鸡胶原蛋白10~15份、米罗那非原粉5~8份、双歧杆菌3~7份、松树皮提取物2~5份、藿香提取物6~9份、卡琪花蒂玛提取物1~3份、槲皮素5~8份、乳酸菌2~5份、燕麦葡聚糖2~5份、沙棘果油3~7份、鞣花酸6~9份。本发明使用经过严格筛选的动植物提取物粉末,接入菌种和离子水,进行厌氧发酵。发酵后保证了有益菌的活性,提高了药效、改变药性,使药效持久、疗效稳定。
Description
技术领域
本发明属于生物医药技术领域,具体涉及一种防治头颈癌的生物组合物。
背景技术
头颈癌与吸烟和酗酒密切相关,烟酒消费高的国家发病率也高,头颈部肿瘤包括源于除眼、脑、耳、甲状腺和食道外头颈部任何组织或器官的肿瘤,应包括颈部肿瘤、耳鼻喉科肿瘤以及口腔颌面部肿瘤三大部分。因此,头颈部所发生的肿瘤,其原发部位和病理类型之多,居全身肿瘤之首,超过90%的头颈部肿瘤为鳞状细胞癌。全球每年约有 645,000 例新发生的头颈部癌病例。在大多数国家,头颈部肿瘤男性多于女性,且年龄≥50岁者多见。欧洲2012年的新发病例约为100800例,40000多例死亡。最近10年全球头颈部鳞状细胞癌(SCCHN)的发病率明显上升,特别是在女性中。
发明内容
本发明所要解决的技术问题在于针对上述现有技术中的不足,提供一种防治头颈癌的生物组合物,该组合物利用了天然微生物发酵技术,使用经过严格筛选的动植物提取物粉末,接入菌种和离子水,进行厌氧发酵。发酵后保证了有益菌的活性,提高了药效、改变药性,使药效持久、疗效稳定。
所述的一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物8~12份、玉米肽5~8份、黄精提取物2~5份、嗜酸乳杆菌3~6份、茯苓多糖6~10份、鸡胶原蛋白10~15份、米罗那非原粉5~8份、双歧杆菌3~7份、松树皮提取物2~5份、藿香提取物6~9份、卡琪花蒂玛提取物1~3份、槲皮素5~8份、乳酸菌2~5份、燕麦葡聚糖2~5份、沙棘果油3~7份、鞣花酸6~9份。
作为本发明的一种优选方案,其特征在于由以下重量份的原料制成:山楂提取物9份、玉米肽7份、黄精提取物3份、嗜酸乳杆菌5份、茯苓多糖7份、鸡胶原蛋白11份、米罗那非原粉6份、双歧杆菌5份、松树皮提取物3份、藿香提取物8份、卡琪花蒂玛提取物2份、槲皮素6份、乳酸菌3份、燕麦葡聚糖5份、沙棘果油5份、鞣花酸8份。
上述的一种防治头颈癌的生物组合物的制备方法为:按所述的重量份称取各原料,按重量份称取原料,放入搅拌发酵容器内,再按比例1:0.3加入离子水,均质搅拌均匀,使原料含水量在30%-40%,再将容器恒温在30°C~35°C,发酵48小时后烘干压片,即得防治头颈癌的生物组合物。
上述一种防治头颈癌的生物组合物的原料功效解析:
山楂提取物:具有扩张血管、增加冠脉血流量、改善心脏活力、兴奋中枢神经系统、降低血压和胆固醇、软化血管及利尿和镇静、强心作用,对老年性心脏病也有益处,有防衰老、抗癌的作用。
玉米肽:改善肝功能,缓解血液芳香族氨基酸浓度过高导致肝昏迷、醒酒活性、抗疲劳、降血压作用。
黄精提取物:补气养阴,健脾,润肺,益肾。用于脾胃虚弱,体倦乏力,口干食少,
茯苓多糖:茯苓味甘、淡、性平,入药具有利水渗湿、益脾和胃、宁心安神之功用,能增强机体免疫功能,茯苓多糖有明显的抗肿瘤及保护肝脏作用。
鸡胶原蛋白:保护骨关节健康、缓解骨关节疼痛或僵硬、促进骨关节弹性和灵活性,促进骨骼代谢机能,防治骨坏死、增强免疫力、改善亚健康、调节血糖、血脂和血粘稠、健美皮肤、促进青少年生长等方面。
米罗那非原粉:补肾保健。
松树皮提取物:具有抗癌,抗炎症和抗过敏,因为自由基在肿瘤形成过程中起着重要的作用,发挥其抗癌功效,同时由于其有效抑制发炎因子,并选择性与关节部的结缔体素结合以缓解疼痛和水肿。
藿香提取物:芳香化浊,开胃止呕,湿浊中阻,脘痞呕吐,暑湿倦怠,胸闷不舒,寒湿闭暑,腹痛吐泻,鼻渊头痛。
卡琪花蒂玛提取物:平衡体内荷尔蒙,改善内分泌引起的微循环紊乱,减少骨质疏松发生、缓解发热潮红、盗汗、失眠症状,减低心血管事件风险,改善情绪,增加自我健康,增加机体能量,让机体更具活力。
槲皮素:有助于防治骨质疏松症,有很强的杀菌能力,预防感冒,对复发性口腔溃疡有一定的治疗效果,具有降血糖、刺激食欲、帮助消化作用,槲皮素中含糖、蛋白质及各种无机盐、维生素等营养成分对机体代谢起一定作用。
燕麦葡聚糖:降低人体胆固醇的合成,对高血脂人群有明显的降低胆固醇的作用。可有效降低餐后血糖浓度和胰岛素水平,降低胆固醇和预防心血管疾病,增强免疫力,改善肠道。
沙棘果油:沙棘果油中类胡萝卜素和维生素E以及多种微量元素如人体不可缺少的维生素A、硒、镁、锌、铁、锰等含量亦较高。
鞣花酸:鞣花酸表现出对化学物质诱导癌变及其他多种癌变有明显的抑制作用,特别是对结肠癌、食管癌、肝癌、肺癌、舌及皮肤肿瘤等有很好的抑制作用,具有优异的抗突变,抗癌变效力。
有益效果:具有扩张血管、增加冠脉血流量、改善心脏活力、兴奋中枢神经系统、降低血压和胆固醇、软化血管及利尿和镇静、强心,减低心血管事件风险,改善情绪,增强机体免疫功能,抗癌防癌,抑制肿瘤,具有优异的抗突变,抗癌变效力。
具体实施方式:
实施例一:
所述的一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物9份、玉米肽6份、黄精提取物3份、嗜酸乳杆菌4份、茯苓多糖7份、鸡胶原蛋白11份、米罗那非原粉6份、双歧杆菌4份、松树皮提取物3份、藿香提取物7份、卡琪花蒂玛提取物1份、槲皮素6份、乳酸菌3份、燕麦葡聚糖3份、沙棘果油4份、鞣花酸7份。
实施例二:
所述的一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物10份、玉米肽7份、黄精提取物4份、嗜酸乳杆菌5份、茯苓多糖8份、鸡胶原蛋白12份、米罗那非原粉7份、双歧杆菌5份、松树皮提取物4份、藿香提取物8份、卡琪花蒂玛提取物2份、槲皮素7份、乳酸菌4份、燕麦葡聚糖4份、沙棘果油5份、鞣花酸8份。
实施例三:
所述的一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物11份、玉米肽8份、黄精提取物5份、嗜酸乳杆菌6份、茯苓多糖9份、鸡胶原蛋白13份、米罗那非原粉8份、双歧杆菌6份、松树皮提取物5份、藿香提取物9份、卡琪花蒂玛提取物3份、槲皮素8份、乳酸菌5份、燕麦葡聚糖5份、沙棘果油6份、鞣花酸9份。
上述的一种防治头颈癌的生物组合物的制备方法为:按所述的重量份称取各原料,按重量份称取原料,放入搅拌发酵容器内,再按比例1:0.3加入离子水,均质搅拌均匀,使原料含水量在30%-40%,再将容器恒温在30°C~35°C,发酵48小时后烘干压片,即得防治头颈癌的生物组合物。
临床应用实例:
选取人群:2015年6月-2016年5月,依据就诊病历,在六所医院筛选头颈癌患者60例,年龄35-65岁,平均年龄约为46岁,病程0.6-2.5年内,所有受试者均经X线双重对比造影、B超检查、癌胚抗原检测,诊断为头颈癌。试验前,将患者随机分为两组,实验组30例和对照组30例,两组在年龄、病程、病情等方面无显著差异。实验组服用本发明实例一所得的一种防治头颈癌的生物组合物,1天3次,每次15-20g,温热水吞服,45天为一个疗程;对照组使用其他常规药物。服药期间对两组患者进行连续观察,记录两组患者肿块大小、数量、位置、质地、活动度和有无压痛的变化情况;停药后持续观察半年,记录复发情况。
疗效判定标准:参照文献疗效标准,(1)显效:肿瘤病变全部消除,症状及体征消失,能维持六周以上;(2)有效:肿瘤病变基本消除,症状及体征明显改善,无新病情出现,能维持六周以上;(3)无效:症状及体征无改善,或出现新病情。
临床结果如下表:
总病例数 | 显效 | 有效 | 无效 | 有效率 | |
实验组 | 30 | 15 | 13 | 2 | 93% |
对照组 | 30 | 5 | 7 | 18 | 40% |
从上表可以说明本发明所得产品疗效显著,可有效缓解病症,且服用本药物组合物均未出现任何毒副反应。
Claims (1)
1.一种防治头颈癌的生物组合物,其特征在于由以下重量份的原料制成:山楂提取物8~12份、玉米肽5~8份、黄精提取物2~5份、嗜酸乳杆菌3~6份、茯苓多糖6~10份、鸡胶原蛋白10~15份、米罗那非原粉5~8份、双歧杆菌3~7份、松树皮提取物2~5份、藿香提取物6~9份、卡琪花蒂玛提取物1~3份、槲皮素5~8份、乳酸菌2~5份、燕麦葡聚糖2~5份、沙棘果油3~7份、鞣花酸6~9份。
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