CN109172798A - 能够活血化瘀、改善子宫虚寒的妇科凝胶 - Google Patents
能够活血化瘀、改善子宫虚寒的妇科凝胶 Download PDFInfo
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Abstract
一种能够活血化瘀、改善子宫虚寒的妇科凝胶,由下列重量份配比的原料组成:人参、茯苓、白术份、肉桂、延胡索、苏木、党参、川贝2、炙黄芪、杜仲、红花、炮姜、艾碳、泽泻、怀牛膝、赤芍、甘草、杭白菊、小茴香、熟地黄、益母草、当归、香附、阿胶、炙甘草、蒲黄、陈皮、三棱、莪术、桃仁、川芎、牡丹皮、红糖、蜂蜜和鹿胎粉。本发明诸药合用,共奏补气养血、调经散寒、化瘀止痛之功效,对调补冲任、滋阴补阳、调节免疫力有着显著的效果。适用于气血不足,虚弱消瘦,腰腿疼痛,精神疲倦,子宫虚寒,月经不调,经期腹痛,血枯经闭,寒湿带下,久不孕育的患者。
Description
技术领域
本发明涉及妇科外用药技术领域,尤其涉及一种能够活血化瘀、改善子宫虚寒的妇科凝胶。
背景技术
不孕症中医认为是由于正气不足所致,病因之本在体虚,病因之标在损伤或感染,病机为正虚邪恋,其病程日久,迁延难愈。治疗需要扶正祛邪,调整阴阳为主。
子宫内膜异位症归属于中医学痛经、不孕症、月经不调等病论治,病因主要与血瘀有关,血瘀是产生子宫内膜异位症的症状和体征的关键;冲任之脉因血瘀而功能失调,经络阻滞,隧道闭塞,冲任气血不通,故见痛经;宿瘀血结,日久不散,阻碍精卵相遇,故可导致不孕症;血瘀于内,新血不得归经,加痰浊内生,痰瘀互结所致月经不调、渐进性痛经、性交痛等症状。
痛经,中医又称经行腹痛,因多思忿怒,情志不舒,疏泄失司,血循不畅而致或受风冷之气客于胞络,损伤冲任之脉所致。
中医中药治疗不孕症、子宫内膜异位症及痛经方面有优势,在解除症状的同时,身体的功能得到调整,并可使患者体质状况得到改善。由于中医药疗效好,毒副作用小,容易被患者所接受。因此寻求一种高效治疗不孕症、子宫内膜异位症及痛经的药物是急待解决的问题。
发明内容
为此,本发明提供一种能够活血化瘀、改善子宫虚寒的妇科凝胶,用以克服现有技术中治疗效率低的问题。
一方面,本发明提供一种能够活血化瘀、改善子宫虚寒的妇科凝胶,它是由下列重量份配比的原料组成:
人参25-30份、茯苓25-30份、白术25-30份、肉桂25-30份、延胡索25-30份、苏木25-30份、党参25-30份、川贝25-30份、炙黄芪15-20份、杜仲15-20份、红花15-20份、炮姜15-20份、艾碳15-20份、泽泻15-20份、怀牛膝15-20份、赤芍15-20份、甘草15-20份、杭白菊15-20份、小茴香15-20份、熟地黄75-80份、益母草75-80份、当归45-50份、香附35-40份、阿胶35-40份、炙甘草8-10份、蒲黄8-10份、陈皮4-5份、三棱4-5份、莪术4-5份、桃仁4-5份、川芎4-5份、牡丹皮4-5份、红糖280-300份、蜂蜜280-300份和鹿胎粉180-200份。
优选地,所述凝胶是由下列重量份配比的原料组成:
人参30份、茯苓30份、白术30份、肉桂30份、延胡索30份、苏木30份、党参30份、川贝30份、炙黄芪20份、杜仲20份、红花20份、炮姜20份、艾碳20份、泽泻20份、怀牛膝20份、赤芍20份、甘草20份、杭白菊20份、小茴香20份、熟地黄80份、益母草80份、当归50份、香附40份、阿胶40份、炙甘草10份、蒲黄10份、陈皮5份、三棱5份、莪术5份、桃仁5份、川芎5份、牡丹皮5份、红糖300份、蜂蜜300份和鹿胎粉200份。
进一步地,其中加入药学上可接受的载体制成适于药用的制剂。
另一方面,本发明提供一种能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,包括:
步骤1:将以上三十五味药材,除蜂蜜、红糖、阿胶、鹿胎粉四味外,将肉桂、延胡索、苏木、泽泻、怀牛膝、赤芍、甘草、杭白菊、小茴香、熟地黄、益母草、当归、香附、陈皮、三棱、莪术、炙甘草、蒲黄、桃仁、川芎和牡丹皮二十一味加8重量倍水煎煮三次,
步骤2:合并所述煎液,滤过,并将滤液浓缩成中药稠膏;
步骤3:将其余十味粉碎成中药细粉;
步骤4:取红糖与阿胶加水溶化,加入蜂蜜、鹿胎粉、上述制备的中药稠膏及中药细粉,混匀,用文火煎熬浓缩,不断搅拌,熬至呈牵缕状不粘手时出锅,放冷,压制成块,粉碎即得。
进一步地,所述步骤1中煎煮三次的时间分别为:第一、二次各2小时,第三次1小时。
进一步地,所述步骤2中滤液浓缩成的中药稠膏密度为1.0-1.2。
进一步地,所述步骤3中的研磨细度为100~120目。
进一步地,所述步骤4中的研磨细度为160~180目。
与现有技术相比,本发明的有益效果在于,本发明诸药合用,共奏补气养血、调经散寒、化瘀止痛之功效,对调补冲任、滋阴补阳、调节免疫力有着显著的效果。适用于气血不足,虚弱消瘦,腰腿疼痛,精神疲倦,子宫虚寒,月经不调,经期腹痛,血枯经闭,寒湿带下,久不孕育的患者。
具体实施方式
为了使本发明的目的和优点更加清楚明白,下面结合实施例对本发明作进一步描述;应当理解,此处所描述的具体实施例仅用于解释本发明,并不用于限定本发明。
一种能够活血化瘀、改善子宫虚寒的妇科凝胶,按照重量份包括:人参30份、茯苓30份、白术30份、肉桂30份、延胡索30份、苏木30份、党参30份、川贝30份、炙黄芪20份、杜仲20份、红花20份、炮姜20份、艾碳20份、泽泻20份、怀牛膝20份、赤芍20份、甘草20份、杭白菊20份、小茴香20份、熟地黄80份、益母草80份、当归50份、香附40份、阿胶40份、炙甘草10份、蒲黄10份、陈皮5份、三棱5份、莪术5份、桃仁5份、川芎5份、牡丹皮5份、红糖300份、蜂蜜300份和鹿胎粉200份。
上述妇科凝胶的制备方法包括:将以上三十五味,除蜂蜜、红糖、阿胶、鹿胎粉四味外,将肉桂、延胡索、苏木、泽泻、怀牛膝、赤芍、甘草、杭白菊、小茴香、熟地黄、益母草、当归、香附、陈皮、三棱、莪术、炙甘草、蒲黄、桃仁、川芎和牡丹皮二十一味加8重量倍水煎煮三次,第一、二次各2小时,第三次1小时,合并煎液,滤过,滤液浓缩成密度为1.0至1.2的中药稠膏;再将其余十味粉碎成100~120目中药细粉;最后,取红糖与阿胶加水溶化,加入蜂蜜、鹿胎粉、上述制备的中药稠膏及中药细粉,混匀,用文火煎熬浓缩,不断搅拌,熬至呈牵缕状不粘手时出锅,放冷,压制成块,粉碎成160~180目细粉,即得。
其中所述鹿胎粉的制备方法:首先用开水烧烫胎儿,摘除胎儿被毛,用清水洗净放入锅内煎煮,当胎儿骨肉分离时停止煎煮,将骨捞出,用纱布过滤胎浆,低温保存备用;再将捞出的骨肉分别放入烘干箱内,60~80℃烘干,头骨和长轴骨可砸碎后再烘干,直至骨肉酥黄纯干为止;最后将纯干的骨肉粉碎成100~120目的鹿胎粉。
对比例:一种妇科用对比凝胶,按重量份包括:
人参30份、茯苓30份、白术30份、肉桂30份、延胡索30份、熟地黄80份、益母草80份、当归50份、香附40份、阿胶40份、怀牛膝20份、炙甘草10份、蒲黄10份、陈皮5份、桃仁5份、川芎5份、牡丹皮5份、红糖300份和蜂蜜300份和鹿胎粉200份。
鹿胎膏的制备方法:以上二十味,除蜂蜜、红糖、阿胶、鹿胎粉四味外,将肉桂、延胡索、熟地黄、益母草、当归、香附、怀牛膝、炙甘草、蒲黄、陈皮、桃仁、川芎和牡丹皮一十三味加8重量倍水煎煮三次,第一、二次各2小时,第三次1小时,合并煎液,滤过,滤液浓缩成密度为1.0至1.2的中药稠膏;再将其余三味粉碎成100~120目中药细粉;最后,取红糖与阿胶加水溶化,加入蜂蜜、鹿胎粉、上述制备的中药稠膏及中药细粉,混匀,用文火煎熬浓缩,不断搅拌,熬至呈牵缕状不粘手时出锅,放冷,压制成块,粉碎成160~180目细粉,即得。
其中所述鹿胎粉的制备方法同实施例。
通过上述能够活血化瘀、改善子宫虚寒的妇科凝胶与对比凝胶针对不同病症进行使用和治疗后进行对比,其中:
凝胶的使用方法:每次5克,每日服药2次,早饭前晚饭后温开水冲服。1个月为一疗程。2~4个疗程统计疗效。
使用注意事项:
1、忌食寒凉、生冷食物。
2、服用鹿胎膏期间不宜喝茶和吃萝卜,不宜同时服用藜芦、五灵脂、皂荚或其制剂。
3、感冒发烧时不宜服用。
4、月经过多者不宜服用。
5、过敏性体质者慎用。
实施例1
本实施例针对凝胶治疗不孕症386例的疗效进行观察:
一般资料:符合以下条件的患者:1、婚后2年以上不孕;2、有痛经或下腹痛病史;3、妇科检查宫骶韧带、子宫直肠陷凹、子宫后壁下段触及痛、硬结节;4、血抗子宫内膜抗体阳性。全部病人子宫、输卵管照影显示子宫正常、输卵管通畅,夫妻同居2年以上,配偶生殖功能正常,未避孕而不受孕者。
临床观察386例,分为2组,治疗组和对比组。
实施例药物用于治疗组282例,≤25岁36例,26~30岁109例,31~35岁83例,36~40岁52例,>41岁2例。不孕年限:2~5年112例,6~10年138例,>10年32例。
对比例药物用于对比组104例,年龄26~30岁,不孕年限:2~8年。
2组资料经统计学处理,差异无显著性意义,具有可比性。
治疗结果:
抗子宫内膜抗体转阴情况:
治疗组282例,2个疗程转阴230例,占81.56%;4个疗程转阴20例,合计转阴250例,转阴率为88.65%,未转阴32例,占11.35%。
对比组104例,2个疗程转阴82例,占78.84%;4个疗程转阴7例,合计转阴89例,转阴率为85.58%,未转阴15例,占14.42%。
痛经及下腹痛改善情况:
治疗组282例,2个疗程疼痛消失89例,减轻64例,4个疗程疼痛消失58例,减轻26例,总有效率84.04%,无改善45例,占15.96%。
对比组104例,2个疗程疼痛消失31例,减轻15例,4个疗程疼痛消失24例,减轻10例,总有效率76.92%,无改善24例,占23.08%。
治疗后妊娠情况:
治疗组250例子宫内膜抗体转阴患者,治疗结束后跟踪6个月经周期,妊娠228例,占91.2%。
对比组80例子宫内膜抗体转阴患者,治疗结束后跟踪6个月经周期,妊娠57例,占71.25%。
两组妊娠患者未发生流产。
实施例2
本实施例针对凝胶治疗子宫内膜异位症的疗效进行观察:
一般资料:符合以下条件的患者:1、渐进性痛经;2、经期少腹、腰骶不适,进行性加剧;3、周期性直肠刺激症状,进行性加剧;4、后穹窿、子宫骶骨韧带或子宫峡部触痛性结节;5、附件粘连包快伴结节感、输卵管通畅;6、月经前后附件上述包块有明显之大小变化。凡有以上1、2、3之1项和4、5、6之1项,结合B超、子宫内膜抗体阳性确诊。
临床观察117例,分为2组,治疗组和对比组。
实施例药物用于治疗组72例,年龄24~52岁,平均34.8岁;病程3月~20年,平均4.1年。
对比例药物用于对比组45例,年龄26~43岁,平均32.2岁;病程3月~12年,平均6.3年。
2组资料经统计学处理,差异无显著性意义,具有可比性。
疗效标准:
痊愈:症状全部消失,盆腔包块等局部体征基本消失,不孕患者在3年内妊娠或生育;显效:症状基本消失,盆腔包块缩小,虽局部体征存在,但不孕患者得以受孕;有效:症状减轻,盆腔包块无增大或略缩小,停药3月症状不加重;无效:主要症状无变化或恶化,局部病变有加重的趋势。
治疗结果:
治疗组痊愈20例,显效32例,有效14例,无效6例,总有效率91.67%。
对比组痊愈11例,显效9例,有效10例,无效15例,总有效率66.67%。
实施例3
本实施例针对凝胶治疗痛经65例的疗效进行观察:
一般资料:符合以下条件的患者:1、妇女在经期或经期前后出现周期性下腹疼痛,伴有其它不适,以致影响工作及生活者;2、原发性痛经:生殖器官无器质性病变而出现痛经者;3、寒凝血瘀型痛经:经前或经期小腹冷痛,经血量少,经行不畅,血色暗有块,畏寒便溏,舌紫暗或有斑点,脉玄或涩。
痛经程度评分标准:
经期或经期前后小腹疼痛计5分;腹痛难忍计1分,腹痛明显计0.5分;坐卧不宁计1分,休克计2分,面色晄白计0.5分,冷汗淋漓计1分,四肢厥冷计1分;需卧床休息计1分,影响工作学习计1分;伴腰骶疼痛计0.5分,伴恶心呕吐计0.5分,伴肛门坠胀计0.5分,伴大便次数增多计0.5分;疼痛在1天内计0.5分,疼痛每增加1天均增计0.5分。重度:积分在14分以上;中度:积分在8~13.5分;轻度:积分在8分以下。
临床观察病例共65例,治疗前均进行肛检、妇检或B超检测,排除盆腔器质性病变后,随机分为2组。
用于实施例药物的治疗组35例,年龄12~32岁,平均19.51岁;其中未婚25例,已婚未育9例,已婚无育1例,病程0.5~12年,平均5.26年;痛经程度:轻度痛经10例,中度痛经19例,重度痛经6例。
用于对比例药物的对比组30例,年龄13~30岁,平均19.53岁;其中未婚21例,已婚未育8例,已婚无育1例,病程0.6~12年,平均5.33年;痛经程度:轻度痛经8例,中度痛经17例,重度痛经5例。
2组资料经统计学处理,差异无显著性意义,具有可比性。
疗效标准:痊愈:服药后经期腹痛及其它症状消失,积分为0,连续3个月经周期未见复发;显效:腹痛明显减轻,其它症状消失或减轻,治疗后积分降至治疗前积分的1/2以下;有效:腹痛减轻,其它症状好转,治疗后积分降至治疗前积分的1/3以下;无效:腹痛及其它症状未见改善。
实施例35味中药与对比例20味中药比较,增加了苏木、党参、川贝、炙黄芪、杜仲、红花、炮姜、艾碳、泽泻、赤芍、甘草、杭白菊、小茴香、三棱、莪术15味。从临床观察效果上看,治疗组明显或显著高于对比组,说明了加入15味中药具有增效作用。
以上所述仅为本发明的优选实施例,并不用于限制本发明;对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (8)
1.一种能够活血化瘀、改善子宫虚寒的妇科凝胶,其特征在于,按重量份包括:
人参25-30份、茯苓25-30份、白术25-30份、肉桂25-30份、延胡索25-30份、苏木25-30份、党参25-30份、川贝25-30份、炙黄芪15-20份、杜仲15-20份、红花15-20份、炮姜15-20份、艾碳15-20份、泽泻15-20份、怀牛膝15-20份、赤芍15-20份、甘草15-20份、杭白菊15-20份、小茴香15-20份、熟地黄75-80份、益母草75-80份、当归45-50份、香附35-40份、阿胶35-40份、炙甘草8-10份、蒲黄8-10份、陈皮4-5份、三棱4-5份、莪术4-5份、桃仁4-5份、川芎4-5份、牡丹皮4-5份、红糖280-300份、蜂蜜280-300份和鹿胎粉180-200份。
2.根据权利要求1所述的能够活血化瘀、改善子宫虚寒的妇科凝胶,其特征在于,按重量份包括:
人参30份、茯苓30份、白术30份、肉桂30份、延胡索30份、苏木30份、党参30份、川贝30份、炙黄芪20份、杜仲20份、红花20份、炮姜20份、艾碳20份、泽泻20份、怀牛膝20份、赤芍20份、甘草20份、杭白菊20份、小茴香20份、熟地黄80份、益母草80份、当归50份、香附40份、阿胶40份、炙甘草10份、蒲黄10份、陈皮5份、三棱5份、莪术5份、桃仁5份、川芎5份、牡丹皮5份、红糖300份、蜂蜜300份和鹿胎粉200份。
3.根据权利要求1或2所述的能够活血化瘀、改善子宫虚寒的妇科凝胶,其特征在于,其中加入药学上可接受的载体制成适于药用的制剂。
4.一种如权利要求1-3任一项权利要求所述的能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,其特征在于,包括:
步骤1:将以上三十五味药材,除蜂蜜、红糖、阿胶、鹿胎粉四味外,将肉桂、延胡索、苏木、泽泻、怀牛膝、赤芍、甘草、杭白菊、小茴香、熟地黄、益母草、当归、香附、陈皮、三棱、莪术、炙甘草、蒲黄、桃仁、川芎和牡丹皮二十一味加8重量倍水煎煮三次,
步骤2:合并所述煎液,滤过,并将滤液浓缩成中药稠膏;
步骤3:将其余十味粉碎成中药细粉;
步骤4:取红糖与阿胶加水溶化,加入蜂蜜、鹿胎粉、上述制备的中药稠膏及中药细粉,混匀,用文火煎熬浓缩,不断搅拌,熬至呈牵缕状不粘手时出锅,放冷,压制成块,粉碎即得。
5.根据权利要求4所述的能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,其特征在于,所述步骤1中煎煮三次的时间分别为:第一、二次各2小时,第三次1小时。
6.根据权利要求4所述的能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,其特征在于,所述步骤2中滤液浓缩成的中药稠膏密度为1.0-1.2。
7.根据权利要求4所述的能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,其特征在于,所述步骤3中的研磨细度为100~120目。
8.根据权利要求4所述的能够活血化瘀、改善子宫虚寒的妇科凝胶的制备方法,其特征在于,所述步骤4中的研磨细度为160~180目。
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