CN109172765A - A kind of drug and preparation method thereof for treating infantile eczema - Google Patents

A kind of drug and preparation method thereof for treating infantile eczema Download PDF

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CN109172765A
CN109172765A CN201811311837.2A CN201811311837A CN109172765A CN 109172765 A CN109172765 A CN 109172765A CN 201811311837 A CN201811311837 A CN 201811311837A CN 109172765 A CN109172765 A CN 109172765A
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parts
drug
treatment
infantile eczema
raw material
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余浚龙
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The present invention relates to drug fields, in particular to a kind of drug and preparation method thereof for treating infantile eczema.The raw material for treating the drug of infantile eczema mainly includes following components by weight: 10-30 parts of kuh-seng, 10-30 parts of garden burnet, 10-30 parts of cortex dictamni, 10-30 parts of the tuber of stemona, 5-30 parts of frutus cnidii and 15-30 parts of Cortex Phellodendri.The tuber of stemona, kuh-seng, cortex dictamni, garden burnet, frutus cnidii and Cortex Phellodendri support dipping medicament, can be imported in skin by pore, and eczema belongs to the illness of skin surface, is more advantageous to treatment.And the present embodiment using drug be to be administered by the way of dipping, do not stimulate the taste of child.The prior art needs to reduce during eczema treatment the frequency had a bath and taken a shower, and the drug provided through this embodiment need not reduce bathing frequency, and tool has a better effect.

Description

A kind of drug and preparation method thereof for treating infantile eczema
Technical field
The present invention relates to drug fields, in particular to a kind of drug and preparation method thereof for treating infantile eczema.
Background technique
Eczema is a kind of scytitis reaction of the acute pruritus as caused by a variety of internal and external factors.Divide acute, subacute, slow Three phases of property.Acute stage tool exudation tendency, chronic phase, then infiltrate, are plump.Over the course for the treatment of, mostly use greatly the means such as oral medicine into Row treatment.
The gastrointestinal peristalsis speed of child is slower, and drug is longer in the time of the gastrointestinal residence of child；There are also be exactly child Son acid concentration is low, the enzymatic activity in gastrointestinal tract is not as good as adult high, drug is more difficult to degrade in the gastrointestinal tract of child.Child's Liver, kidney development are also incomplete, and enzyme system needed for drug degradation is also unsound, and the metabolism of drug and drainage rate can all slow down, because This, is easy to accumulate drug in child's body, once being more than toxic dose, will result in serious adverse reaction.Therefore child Sub- medication can bring certain injury to its liver, kidney.
Summary of the invention
The purpose of the present invention is to provide a kind of drugs and preparation method thereof for treating infantile eczema, are intended to provide one kind It can avoid damaging child liver, kidney while treating infantile eczema.
The present invention provides a kind of technical solution:
A kind of drug for treating infantile eczema, treat the drug of infantile eczema raw material mainly include by weight with Lower component:
10-30 parts of kuh-seng, 10-30 parts of garden burnet, 10-30 parts of cortex dictamni, 10-30 parts of the tuber of stemona, 5-30 parts of frutus cnidii and Huang 15-30 parts of cypress；The medicine preparation for treating infantile eczema is percutaneous drug delivery dosage form.
In other embodiments of the invention, above-mentioned raw materials mainly include following components by weight:
16-24 parts of kuh-seng, 15-26 parts of garden burnet, 18-21 parts of cortex dictamni, 17-23 parts of the tuber of stemona, 9-17 parts of frutus cnidii and Huang 21-27 parts of cypress.
In other embodiments of the invention, above-mentioned raw materials mainly include following components by weight:
19 parts of kuh-seng, 21 parts of garden burnet, 20 parts of cortex dictamni, 19 parts of the tuber of stemona, 15 parts of frutus cnidii and 24 parts of Cortex Phellodendri.
In other embodiments of the invention, the drug of above-mentioned treatment infantile eczema further includes auxiliary material.
The present invention also provides a kind of technical solutions:
The preparation method of the drug of above-mentioned treatment infantile eczema, mainly comprises the steps that
Raw material is adopted to mixed filtrate after being extracted with water 2-3 times, then filter vacuum is concentrated.
In other embodiments of the invention, it is above-mentioned raw water is extracted before, further include that raw material is mixed into immersion with water 30-60 minutes.
In other embodiments of the invention, it is above-mentioned raw water is extracted before, further include crush raw material to cross 100 mesh.
In other embodiments of the invention, preservative is added in the above-mentioned filtrate to after vacuum concentration.
In other embodiments of the invention, after above-mentioned water extracts, before filter vacuum concentration further include:
By the dregs of a decoction squeezed to obtain raffinate, mix raffinate and then filtrate be concentrated in vacuo.
In other embodiments of the invention, the volume ratio of raw material and water is 0.8:1-1.5 in above-mentioned water extraction step.
The beneficial effect of the drug for the treatment of infantile eczema provided in an embodiment of the present invention and preparation method thereof is:
The tuber of stemona, kuh-seng and cortex dictamni clearing heat and expelling damp, removing toxic substances wind-dispelling, antipruritic, cure mainly eczema, can alleviate illness quickly. Garden burnet, frutus cnidii and the compatible astringing to arrest bleeding of Cortex Phellodendri, purging fire for removing toxin；The tuber of stemona, kuh-seng and cortex dictamni is assisted to treat eczema.And The tuber of stemona, kuh-seng, cortex dictamni, garden burnet, frutus cnidii and Cortex Phellodendri do not stimulate skin mildly.
The tuber of stemona, kuh-seng, cortex dictamni, garden burnet, frutus cnidii and Cortex Phellodendri support dipping medicament, can import skin by pore It is interior, and eczema belongs to the illness of skin surface, is more advantageous to treatment.And the present embodiment using drug be by the way of dipping to Medicine does not stimulate the taste of child.The prior art needs to reduce during eczema treatment the frequency had a bath and taken a shower, by this implementation The drug that example provides need not reduce bathing frequency, and tool has a better effect.
Drug provided in this embodiment can be impaired to avoid liver and taste, and the skin of children is thinner than adult skin, transdermal Assimilation effect is good, and drug provided in this embodiment is compared by inventor with the antipyretic of pharmacy, and the embodiment of the present invention provides Drug side-effect it is smaller, the influence to liver kidney is smaller；And it does not rebound after bringing down a fever.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase Product.
The drug and preparation method thereof of the treatment infantile eczema of the embodiment of the present invention is specifically described below.
The present invention provides a kind of technical solution:
A kind of drug for treating infantile eczema, treat the drug of infantile eczema raw material mainly include by weight with Lower component:
10-30 parts of kuh-seng, 10-30 parts of garden burnet, 10-30 parts of cortex dictamni, 10-30 parts of the tuber of stemona, 5-30 parts of frutus cnidii and Huang 15-30 parts of cypress；The medicine preparation for treating infantile eczema is percutaneous drug delivery dosage form.
Kuh-seng: bitter, it is cold in nature, enter the heart, liver, stomach, large intestine and bladder meridian.With heat-clearing and damp-drying drug, desinsection, diuresis effect.Clearly It is especially kind among hot eliminating dampness to remove damp-heat in lower-JIAO, control the dysentery of letting out of damp-heat accumulation large intestine, discharging fresh blood stool and all diseases of leukorrhagia.And energy diuresis, It dispels bladder damp-heat, controls difficulty and pain in micturition.And kind wind-dispelling, desinsection are antipruritic.It is common by many dermatosis chronic diseases.
Garden burnet: bitter, acid, puckery, cold nature return liver, large intestine channel.This product bitter it is cold in nature enter blood system, be longer than and expel the heat-evil and cool blood Hemostasis；Taste and sour and astringent, but can astringing to arrest bleeding, the card of Zhiduo County's kind blood-head bleeding can be used.Bitter cold energy purging fire for removing toxin, sour-puckery flavor can be held back Sore, for the key medicine for controlling scald.
Cortex dictamni: bitter, it is cold in nature, enter spleen, stomach meridian.Function is apt to heat-clearing and damp-drying drug, removing toxic substances, dispelling wind and arresting itching, is to control skin eczema.It is wet Sore, scabies are commonly used；Again can clearing heat and promoting diuresis and removing jaundice subcutaneous ulcer, control jaundice with damp-heat pathogen；Can also wind-dispelling paralysis, to control damp and hot paralysis.
Frutus cnidii: acrid flavour, it is bitter, it is warm-natured；Returns spleen, kidney channel.With warming kidney and enhancing body, the effect of removing dampness and destroying parasites, dispelling wind and arresting itching.
The tuber of stemona: this product bitter drop in sweet flavor, tepor is not dry, and medicinal peace is transferred to lung channel.Function arrogates to oneself moistening lung to arrest cough, and kind desinsection goes out Lice controls pinworm, Trichomonas vaginalis, head louse agent scabies etc..
Cortex Phellodendri: the sedimentation of this product bitter cold is longer than and rushes down damp-heat in lower-JIAO clearly.Among heat-clearing and damp-drying drug, it is apt to except large intestinal damp-heat is to control dysentery, The jaundice of retention and fumigation of damp-heat inside the body can be controlled.Can heat-clearing and damp-drying drug and purging fire for removing toxin, with controlling sore swollen toxin.
The tuber of stemona, kuh-seng and cortex dictamni clearing heat and expelling damp, removing toxic substances wind-dispelling, antipruritic, cure mainly eczema, can alleviate illness quickly. Garden burnet, frutus cnidii and the compatible astringing to arrest bleeding of Cortex Phellodendri, purging fire for removing toxin；The tuber of stemona, kuh-seng and cortex dictamni is assisted to treat eczema.And The tuber of stemona, kuh-seng, cortex dictamni, garden burnet, frutus cnidii and Cortex Phellodendri do not stimulate skin mildly.
The tuber of stemona, kuh-seng, cortex dictamni, garden burnet, frutus cnidii and Cortex Phellodendri support dipping medicament, can import skin by pore It is interior, and eczema belongs to the illness of skin surface, is more advantageous to treatment.And the present embodiment using drug be by the way of dipping to Medicine does not stimulate the taste of child.The prior art needs to reduce during eczema treatment the frequency had a bath and taken a shower, by this implementation The drug that example provides need not reduce bathing frequency, and tool has a better effect.
Further, in an embodiment of the present invention, raw material mainly includes following components by weight:
26-35 parts of radix bupleuri, 8-16 parts of peppermint, 8-16 parts of cortex cinnamomi, 16-28 parts of schizonepeta, 8-17 parts of radix saposhnikoviae, 8-17 parts of radix scutellariae, 16-25 parts of the tuber of pinellia, 13-17 parts of ramulus cinnamomi, 16-25 parts of Radix Codonopsis, 8-13 parts of ginger, 9-17 parts of jujube and 12-18 parts of Radix Glycyrrhizae.
In the present embodiment, raw material mainly includes following components by weight:
27 parts of radix bupleuri, 12 parts of peppermint, 11 parts of cortex cinnamomi, 19 parts of schizonepeta, windproof 13 parts, 13 parts of radix scutellariae, 21 parts of the tuber of pinellia, ramulus cinnamomi 16 Part, 19 parts of Radix Codonopsis, 11 parts of ginger, 12 parts of jujube and 16 parts of Radix Glycyrrhizae.
Further, the drug for treating infantile eczema further includes auxiliary material.Auxiliary material can be alcohol, water, preservative etc..
The present invention also provides a kind of technical solutions:
The preparation method of the drug of above-mentioned treatment infantile eczema, mainly comprises the steps that
Raw material is adopted to mixed filtrate after being extracted with water 2-3 times, then filter vacuum is concentrated.
Adopt the drug ingedient being extracted with water in raw material, vacuum concentration filtrate is to precipitating crystal.Alternatively, in other embodiments In, vacuum concentration filtrate to filtrate is lotion.
Material is not affected by high temperatures in vacuum Concentrating Process, avoids the destruction and loss of thermally labile component, preferably Save the nutritional ingredient and fragrance of raw material.Especially ramulus cinnamomi, readily volatilized effective component are protected well under this cryogenic vacuum Its effective component is deposited.
In preferred embodiments of the present invention, it is above-mentioned raw water is extracted before, further include that raw material is mixed into immersion with water 30-60 minutes.The effective component that soaking process can increase in drug enters in solution.
In preferred embodiments of the present invention, it is above-mentioned raw water is extracted before, further include crush raw material to cross 100 mesh. Correspondingly, crushing raw material can also promote more raw materials in drug to enter in solution to 100 mesh are crossed.
In preferred embodiments of the present invention, preservative is added in the above-mentioned filtrate to after vacuum concentration.It is stored up to drug Before depositing, preservative is added in the filtrate after vacuum concentration, can be grown to avoid bacterium etc..
In preferred embodiments of the present invention, after above-mentioned water extracts, before filter vacuum concentration further include:
By the dregs of a decoction squeezed to obtain raffinate, mix raffinate and then filtrate be concentrated in vacuo.The dregs of a decoction are pressed Squeezing obtains raffinate, mixes raffinate and then filtrate is concentrated in vacuo.
In preferred embodiments of the present invention, the volume ratio of raw material and water is 0.8:1-1.5 when above-mentioned water extracts.Above-mentioned water The volume ratio of raw material and water is 0.8:1-1.5 when extraction.
In the present embodiment, water extraction refers to, uses instead and is cooked by slow fire after boiling by intense fire.
In other embodiments of the invention, the preparation method for treating the drug of infantile eczema also may include other steps Suddenly, it for example, directly carrying out boiling to raw material, is filtered after boiling, dipping is carried out to children using filtrate.
It should be noted that in the present invention, the children refer to 0-8 years old child.Child especially to 0-6 years old Effect it is preferable.The drug for the treatment of infantile eczema provided in this embodiment also correspondingly has effect to adult, small to 0-6 years old Child has better effect.
In the present embodiment, in the pharmaceutical procedures using treatment infantile eczema, first water is heated to the temperature that can be taken a shower Degree, then drug is mixed with hot water, dipping then is carried out to child.
In the present embodiment, drug is to be treated in a manner of lotion subsequently through dipping.It should be noted that In the other embodiment of the present invention, drug may be other dosage forms, such as liniment, ointment, emplastrum, paste, patch, spray Other dosage forms such as paint.
Drug provided in this embodiment can be impaired to avoid liver and taste, and the skin of children is transdermal than adult skin packet Assimilation effect is good, and drug provided in this embodiment is compared by inventor with the antipyretic of pharmacy, and the embodiment of the present invention provides Drug side-effect it is smaller, the influence to liver kidney is smaller；And it does not rebound after bringing down a fever.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
10-30 parts of kuh-seng, 10-30 parts of garden burnet, 10-30 parts of cortex dictamni, 10-30 parts of the tuber of stemona, 5-30 parts of frutus cnidii and Huang 15-30 parts of cypress.
Raw material is crushed to 100 mesh are crossed, adopts mixed filtrate after being extracted with water 3 times, the volume ratio of raw material and water is respectively after 3 times 0.8:1,0.8:1.2,0.8:1.5.
Then filter vacuum solid precipitation has been concentrated into；It bottles after preservative is added.
Embodiment 2
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
10 parts of kuh-seng, 10 parts of garden burnet, 10 parts of cortex dictamni, 10 parts of the tuber of stemona, 55 parts of frutus cnidii and 15 parts of Cortex Phellodendri.
Raw material is crushed to 100 mesh are crossed, is extracted being boiled 35 minutes after raw material and boiling boiling, water mixes filter after extracting 3 times Then filter vacuum has been concentrated into solid precipitation by liquid；It bottles after preservative is added.
Embodiment 3
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
30 parts of kuh-seng, 30 parts of garden burnet, cortex dictamni 30,30 parts of the tuber of stemona, 30 parts of frutus cnidii and 30 parts of Cortex Phellodendri.
Raw material is crushed to 100 mesh are crossed, is extracted being boiled 35 minutes after raw material and boiling boiling, water mixes filter after extracting 3 times Then filter vacuum has been concentrated into solid precipitation by liquid；It bottles after preservative is added.
Embodiment 4
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
16 parts of kuh-seng, 15 parts of garden burnet, 18 parts of cortex dictamni, 17 parts of the tuber of stemona, 9 parts of frutus cnidii and 21 parts of Cortex Phellodendri.
Raw material is mixed to immersion 50 minutes with water；It is extracted being boiled 35 minutes after raw material and boiling boiling, after water extracts 3 times Then filter vacuum has been concentrated into solid precipitation by mixed filtrate；It bottles after preservative is added.
Embodiment 5
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
24 parts of kuh-seng, 26 parts of garden burnet, 21 parts of cortex dictamni, 23 parts of the tuber of stemona, 17 parts of frutus cnidii and 27 parts of Cortex Phellodendri.
Raw material is mixed to immersion 40 minutes with water；It is extracted being boiled 30 minutes after raw material and boiling boiling, after extracting twice Then filter vacuum has been concentrated into solid precipitation by mixed filtrate；It bottles after preservative is added.
Embodiment 6
A kind of drug for treating infantile eczema is present embodiments provided, lotion is made in the drug for treating infantile eczema, it is main It to be made by following steps:
24 parts of kuh-seng, 26 parts of garden burnet, 21 parts of cortex dictamni, 23 parts of the tuber of stemona, 17 parts of frutus cnidii and 27 parts of Cortex Phellodendri.
It is extracted being boiled 30 minutes after raw material and boiling boiling, mixed filtrate after water extracts 2 times is then dense by filter vacuum It has been reduced to solid precipitation；It bottles after preservative is added.
Case
Lee, girl baby, 2 years old half.Based on small papule, incrustation and the scales of skin that peel off, a small amount of papulo-vesicle, itch redness.Use embodiment 1 The drug dipping of offer 7 days, twice a day, each dipping 30 minutes.Start to improve after 3 days, fully recover after 7 days.
It is remaining certain, boy baby, 4 years old.After ear, distal limbs have small papule.The drug dipping provided using embodiment 25 days, one It twice, each dipping 30 minutes.Start to improve after 3 days, fully recover after 5 days.
Zheng, boy baby, 9 months 3 years old, on hand have small papule, the drug dipping provided using embodiment 33 days, one day two It is secondary, each dipping 30 minutes.Start to improve after 1 day, fully recover after 3 days.
Zhao, girl baby, 11 months 2 years old, shank had eczema, fell ill 3 months, the drug dipping 15 provided using embodiment 4 It, twice a day, each dipping 30 minutes.Start to improve after 4 days, fully recover after 15 days.
Qian, girl baby, 7 years old, after ear, both hands have eczema, fall ill 8 months, the drug dipping 15 provided using embodiment 5 It, twice a day, each dipping 30 minutes.Start to improve after 4 days, fully recover after 15 days.
By above-mentioned case it is found that the drug for the treatment infantile eczema that embodiment 1- embodiment 6 provides to treat children wet Rash, and therapeutic effect is preferable.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of drug for treating infantile eczema, which is characterized in that the raw material of drug of the treatment infantile eczema mainly includes Following components by weight:
10-30 parts of kuh-seng, 10-30 parts of garden burnet, 10-30 parts of cortex dictamni, 10-30 parts of the tuber of stemona, 5-30 parts of frutus cnidii and Cortex Phellodendri 15- 30 parts；The medicine preparation of the treatment infantile eczema is percutaneous drug delivery dosage form.
2. the drug for the treatment of infantile eczema according to claim 1, which is characterized in that the raw material mainly includes by weight The following components of part meter:
Described kuh-seng 16-24 parts, garden burnet 15-26 parts described, cortex dictamni 18-21 parts described, the tuber of stemona 17-23 parts described, snake 9-17 parts of machine tool and Cortex Phellodendri 21-27 parts described.
3. the drug for the treatment of infantile eczema according to claim 1, which is characterized in that the raw material mainly includes by weight The following components of part meter:
19 parts of the kuh-seng, 21 parts of the garden burnet, 20 parts of the cortex dictamni, 19 parts of the tuber of stemona, 15 parts of the frutus cnidii and 24 parts of the Cortex Phellodendri.
4. the drug for the treatment of infantile eczema according to claim 1, which is characterized in that the drug of the treatment infantile eczema It further include auxiliary material.
5. the preparation method of the drug for the treatment of infantile eczema according to any one of claims 1-4, which is characterized in that main packet Include following steps:
The raw material is adopted to mixed filtrate after being extracted with water 2-3 times, then the filter vacuum is concentrated.
6. the preparation method of the drug for the treatment of infantile eczema according to claim 5, which is characterized in that by the raw water It further include that the raw material is mixed to immersion 30-60 minutes with water before extraction.
7. the preparation method of the drug for the treatment of infantile eczema according to claim 5, which is characterized in that by the raw water It further include crushing the raw material to 100 mesh excessively before extraction.
8. the preparation method of the drug for the treatment of infantile eczema according to claim 5, which is characterized in that after vacuum concentration The filtrate in preservative is added.
9. the preparation method of the drug for the treatment of infantile eczema according to claim 5, which is characterized in that after water extracts, Before the filter vacuum concentration further include:
By the dregs of a decoction squeezed to obtain raffinate, mix the raffinate and the filtrate and then be concentrated in vacuo.
10. the preparation method of the drug for the treatment of infantile eczema according to claim 5, which is characterized in that water extraction step Described in the volume ratio of raw material and water be 0.8:1-1.5.
CN201811311837.2A 2018-11-06 2018-11-06 A kind of drug and preparation method thereof for treating infantile eczema Pending CN109172765A (en)

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CN201811311837.2A CN109172765A (en) 2018-11-06 2018-11-06 A kind of drug and preparation method thereof for treating infantile eczema

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811311837.2A CN109172765A (en) 2018-11-06 2018-11-06 A kind of drug and preparation method thereof for treating infantile eczema

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Publication Number Publication Date
CN109172765A true CN109172765A (en) 2019-01-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811311837.2A Pending CN109172765A (en) 2018-11-06 2018-11-06 A kind of drug and preparation method thereof for treating infantile eczema

Country Status (1)

Country Link
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