CN109172444A - A kind of leave hand cleanser and preparation method thereof - Google Patents
A kind of leave hand cleanser and preparation method thereof Download PDFInfo
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- CN109172444A CN109172444A CN201811120802.0A CN201811120802A CN109172444A CN 109172444 A CN109172444 A CN 109172444A CN 201811120802 A CN201811120802 A CN 201811120802A CN 109172444 A CN109172444 A CN 109172444A
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- hand cleanser
- leave hand
- mixture
- essential oil
- leave
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
Abstract
The present invention provides a kind of leave hand cleanser, including following components in percentage by weight: benzalkonium chloride 0.025-0.10%, and persimmon berry extract 0.1-2.0%, polyquaternium 0.3-1.2%, surplus is deionized water.The leave hand cleanser efficient sterilizing, deodorizing capability is strong, healthy skin care；It can be avoided caused skin irritatin, dry skin or allergic phenomena.The present invention also provides a kind of preparation methods of leave hand cleanser, the following steps are included: weigh each component by formula rate, after mixing by polyquaternium and deionized water, it is warming up to 80-85 DEG C, stirring forms the first mixture of transparent gel-form, be subsequently cooled to 40-45 DEG C it is spare；Benzalkonium chloride, persimmon berry extract are added in first mixture obtained second mixture and after mixing evenly by second mixture obtain leave hand cleanser.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of leave hand cleanser and preparation method thereof.
Background technique
The ubiquitous spread of germs source moment threatens the health of people in daily life, and disinfection hand cleanser also increasingly obtains
To the approval of consumer, and appear in various public situations.Currently, disinfection hand cleanser is that hand cleanser occupancy volume is maximum in the market
It is a kind of；Wherein, the features such as leave disinfection hand cleanser is by its easy to use, easy to carry and saving water resource is deeper by all kinds of
Consumer's likes.
The common leave disinfection hand cleanser kind in market is more at present, but most of with certain defect, and what is had is inflammable
And it is irritant；Some storages for a long time are unstable easy to be separated；Disposable anti-bacteriostatic hand sanitizer viscosity also is low, and appearance picture disappears
Malicious water, it is inconvenient to use.For example, investigation show most of leave disinfection hand cleanser main component be sterilizing at
Point and volatile component.Wherein, the most prominent as solvent using the volatility such as ethyl alcohol alcohols.Disposable sterilization existing at present is washed one's hands
Liquid ethanol content is generally 55-65%, or more low ethanol content needs to compound other fungicide.But add the Non-water washing of ethyl alcohol
Hand liquid is easy to produce the disadvantages of stimulation decortication is dry in the presence of the smell is awful.
Therefore, it is necessary to develop a kind of disposable hand cleanser that can be free of ethyl alcohol and efficient sterilizing, safe skin care.
Summary of the invention
In view of this, the present invention provides a kind of leave hand cleanser and preparation method thereof, which can be with
Efficiently, long-acting bactericidal inhibits bacteria breed, effective protection skin safe；The leave hand cleanser is mild, comfortable, health shield
Skin can be avoided caused skin irritatin, dry skin or allergic phenomena.
In a first aspect, the present invention is referred to a kind of leave hand cleanser, including following components in percentage by weight: benzene pricks chlorine
Ammonium 0.025-0.10%, persimmon berry extract 0.1-2.0%, polyquaternium 0.3-1.2%, surplus is deionized water.
Further, optionally, weight percent of the benzalkonium chloride in the leave hand cleanser is 0.03-
0.10%.It for example, weight percent of the benzalkonium chloride in the leave hand cleanser is 0.025%, or is 0.03%,
It or is 0.05%, or be 0.065%, or be 0.08%, or be 0.09%, or be 0.10%.Benzalkonium chloride tool of the present invention
There are prominent, wide spectrum biocidal efficacies, can effectively, quickly be sterilized.
Optionally, weight percent of the polyquaternium in the leave hand cleanser is 0.5-1.0%.For example,
Weight percent of the polyquaternium in the leave hand cleanser is 0.3%, or is 0.5%, or is 0.8%, or be
1.0%, or be 1.2%.In the present invention, the polyquaternium can be used for participating in forming clear gel.Preferably, the polyquaternary amine
Salt includes polyquaternium -37.
Optionally, weight percent of the persimmon berry extract in the leave hand cleanser is 0.3-1.2%.Example
Such as, weight percent of the persimmon berry extract in the leave hand cleanser is 0.1%, or is 0.3%, or is 0.5%,
It or is 0.8%, or be 1.0%, or be 1.2%, or be 1.5%, or be 1.8%, or be 2.0%.
Optionally, the persimmon berry extract includes tannic acid, sodium lactate.Further, optionally, the persimmon berry extract
It further include the other compositions such as alcohol compound.Wherein, weight percent of the tannic acid in the persimmon berry extract is
1%-10%.Further, optionally, weight percent of the tannic acid in the persimmon berry extract is 1%-5%.Into
One step, optionally, weight percent of the tannic acid in the persimmon berry extract is 6%-10%.Persimmon of the present invention
Berry extract can be extracted from natural persimmon fruit and be obtained；On the one hand the persimmon berry extract can promote well and improve benzene
Prick sterilization, the bacteriostasis of oronain；On the other hand, the persimmon berry extract has deodorizing capability outstanding；In another aspect, described
Persimmon berry extract also has certain moisturizing, skin-care effect.
Optionally, the leave hand cleanser further includes the polyalcohol that weight percent is 1.0-5.0%.Optionally, institute
Stating polyalcohol further includes one of 1,2- hexylene glycol, glycerol, butanediol and sorbierite or a variety of.For example, the polyalcohol packet
Include 1,2- hexylene glycol；Or the polyalcohol includes 1,2- hexylene glycol and glycerol.Polyalcohol of the present invention, which has, assists to promote suppression
The effect of bacterium, the polyalcohol are mild, non-stimulated；And the polyalcohol also has certain moisture-keeping function, skin can be made to tie up
It holds in the equilibrium state for being higher than normal water content, plays the role of mitigating dry skin.
Further, optionally, the polyalcohol includes at least one of glycerol, butanediol and sorbierite and 1,2- oneself
Glycol.For example, the polyalcohol includes 1,2- hexylene glycol and glycerol；Or the polyalcohol includes the 1,2- hexylene glycol and fourth two
Alcohol；Or the polyalcohol includes 1,2- hexylene glycol and sorbierite；Or the polyalcohol includes the 1,2- hexylene glycol, glycerol and fourth
Glycol.Optionally, the polyalcohol is at least one of the glycerol, the butanediol and described sorbierite and described 1,2-
By the compositional liquor of constant weight percentage composition, weight percent of 1, the 2- hexylene glycol in the compositional liquor between hexylene glycol
Than for 20-80%.The 1,2- hexylene glycol, which has, promotes antibacterial effect.
Optionally, the leave hand cleanser further include weight percent be 0.1-0.6% plant origin solubilizer and
Weight percent is the plants essential oil of 0.01-0.2%.
Further, optionally, weight percent of the plant origin solubilizer in the leave hand cleanser is
0.2-0.5%.For example, weight percent of the plant origin solubilizer in the leave hand cleanser is 0.1%, or it is
0.2%, or be 0.3%, or be 0.4%, or be 0.5%, or be 0.6%.The plant origin solubilizer is mild, non-stimulated,
It can effectively be promoted and plants essential oil is promoted to dissolve to form uniform, clear solution.Optionally, the plant origin solubilizer includes pungent
Acid/glycerol decanoate class Natrulon H-10 esters.
Further, optionally, the plants essential oil is 0.05- in the weight percent content of the leave hand cleanser
0.15%.It for example, weight percent of the plants essential oil in the leave hand cleanser is 0.01%, or is 0.05%,
It or is 0.08%, or be 0.1%, or be 0.12%, or be 0.15%, or be 0.18%, or be 0.2%.Optionally, the plant
Object essential oil includes one of yellow chamomile essential oil, Rosemary Oil, Salvia japonica essential oil, lemon and Lavender or more
Kind.Plants essential oil of the present invention is obtained by extracted form natural plant；The plants essential oil has attached Xiang Gong energy, the plants essential oil
It can accelerate to allay nervousness to a certain extent, the impression of euthymia is brought to people.
Optionally, the leave hand cleanser further includes the D-lactic acid that weight percent is 0.001-0.005%.Into one
Step ground, optionally, weight percent of the D-lactic acid in the leave hand cleanser are 0.001-0.003%.For example,
Weight percent of the D-lactic acid in the leave hand cleanser is 0.001%, or is 0.002%, or be
0.003%, or be 0.004%, or be 0.005%.D-lactic acid of the present invention has the characteristics that mild, non-stimulated, can be used for
Adjust the pH of the leave hand cleanser；Meanwhile the D-lactic acid also has certain bacteriostasis efficacy, can participate in and be promoted
The whole degerming of leave hand cleanser of the present invention, fungistatic effect enable the leave hand cleanser more efficiently to remove
Bacterium.
Optionally, the pH of the leave hand cleanser is 5.0-6.0.In the present invention, the leave hand cleanser can be presented
Faintly acid, the pH of the leave hand cleanser are the pH normal range (NR) that 5.0-6.0 numberical range meets human skin, can be significantly
Stimulation of the leave hand cleanser to human skin is reduced, sense of touch is mild, and various people is suitble to use, and especially baby is virgin.
Optionally, the form of the leave hand cleanser is transparent gel-form.
A kind of leave hand cleanser that first aspect present invention proposes has wide spectrum, efficient bactericidal effect, can
The various germs that site of action is eliminated within the of short duration time, inhibit the growth of germ；Meanwhile leave hand cleanser of the present invention
Appearance be clear gel, the impurity sense such as particle will not be carried out to the skin tape of user, can have good usage experience sense.
Further, the leave hand cleanser not spirituosity, pigment, compound essence or the sensitizer in mineral oil source；With pair
The features such as skin is mildly nonirritant is suitble to various people to use, and especially baby is virgin.
Second aspect, the present invention also provides a kind of preparation methods of leave hand cleanser, comprising:
Each component is weighed by formula rate, after mixing by polyquaternium and deionized water, 80-85 DEG C is warming up to, stirs
Mix the first mixture to form transparent gel-form, be subsequently cooled to 40-45 DEG C it is spare；
Benzalkonium chloride, persimmon berry extract are added in first mixture, the second mixture is made, by described second
Mixture after mixing evenly, obtains leave hand cleanser.
Optionally, described to be additionally added polyalcohol while be uniformly mixed polyquaternium and deionized water；It is described polynary
Alcohol is conducive to be promoted the synthesis speed of first mixture.Optionally, polyalcohol includes 1,2- hexylene glycol, glycerol, butanediol
With one of sorbierite or a variety of.The butanediol includes 1,3 butylene glycol.
Optionally, the polyquaternium includes polyquaternium -37.
Optionally, by it is described benzalkonium chloride, persimmon berry extract are added in first mixture while, to described
Polyalcohol is added in first mixture, and the second mixture is made.In the present invention, in the preparation method of the leave hand cleanser, institute
Stating polyalcohol can be, but not limited to be divided into two parts, and a part participates in preparing first mixture；Another part participates in preparation
Second mixture.
Optionally, described while be added to benzalkonium chloride, persimmon berry extract in first mixture, to described
Plants essential oil transparent liquid being added in one mixture, the second mixture being made, the preparation process of the plants essential oil transparent liquid includes:
Plants essential oil and plant origin expanding material are weighed by formula rate, the plants essential oil is dispersed to the plant origin expanding material
In, obtain the plants essential oil transparent liquid.
Further, optionally, the plant origin solubilizer includes caprylic/capric glyceride type Natrulon H-10 esters.
The plants essential oil includes one of yellow chamomile essential oil, Rosemary Oil, Salvia japonica essential oil, lemon and Lavender
Or it is a variety of.
Optionally, it is described by second mixture after mixing evenly, the pH for adjusting second mixture is 5.0-
6.0.In the preparation method, the pH of second mixture can be adjusted by adding some acidic ph modifiers,
Such as D-lactic acid.
Preferably, the present invention also provides a kind of preparation methods of leave hand cleanser, comprising:
(a) each component is weighed by formula rate, wherein polyalcohol is divided into part polyalcohol and remaining polyalcohol, is taken poly-
Quaternary ammonium salt is dispersed in the part polyalcohol, after deionized water then is added, is warming up to 80-85 DEG C to form transparent coagulate
Colloidal mixture, be then cooled to 40-45 DEG C it is spare；
(b) it takes essential oil dispersion into plant origin expanding material, obtains plants essential oil transparent liquid, it is spare；
(c) benzalkonium chloride, persimmon berry extract and the remaining polyalcohol are taken, the benzalkonium chloride, the persimmon fruit are extracted
It object, the remaining polyalcohol, the plants essential oil transparent liquid and is cooled to 40-45 DEG C of the mixture and stirs evenly together,
Adjusting pH is 5.0-6.0, obtains leave hand cleanser.
Optionally, the weight ratio of the step (a), the part polyalcohol and the polyquaternium is 3:2.Further
Ground, entirely in the preparation method of the leave hand cleanser, the weight percent of the polyalcohol is 1.0-5.0%.
Optionally, in the leave hand cleanser, the weight percent of each component includes: the benzalkonium chloride 0.025-
0.10%, the persimmon berry extract 0.1-2.0%, the polyquaternium 0.3-1.2%, the polyalcohol 1.0-5.0% is described
Plant origin solubilizer 0.1-0.6%, the plants essential oil 0.01-0.2%, surplus is deionized water.
Optionally, the preparation method of persimmon berry extract can be, but not limited to include: to pulverize persimmon fruit, and sieving obtains persimmon fruit powder
End adds distilled water immersion, is then heated to boiling, keeps the temperature, and filtering is concentrated to get persimmon berry extract.
The preparation method for the leave hand cleanser that second aspect of the present invention provides, technique are simplified, and reaction condition is mild, cost
It is low, easily realize industrialization production.Leave hand cleanser of the present invention is mildly non-stimulated；Including the persimmon berry extract and
The benzalkonium chloride, the two cooperate, and leave hand cleanser obtained by the present invention is made to have more broad spectrum antibacterial performance；In conjunction with
Plants essential oil with bacteriostasis efficacy further increases degerming of the invention, antibacterial effect.
The third aspect includes leave hand cleanser or second aspect described in first aspect present invention the present invention also provides one kind
Application of the leave hand cleanser that the preparation method is prepared in daily necessities field.
The leave that preparation method described in leave hand cleanser or second aspect described in first aspect present invention is prepared
Hand cleanser under the premise of efficient degerming, also with skin care, Non-water washing the advantages of, have broad application prospects.
The advantages of inventive embodiments, will partially illustrate in the following description, and a part is aobvious and easy according to specification
See, or can implementation through the embodiment of the present invention and know.
Specific embodiment
As described below is the preferred embodiment of the embodiment of the present invention, it is noted that for the common skill of the art
For art personnel, without departing from the principles of the embodiments of the present invention, several improvements and modifications can also be made, these improvement
Also it is considered as the protection scope of the embodiment of the present invention with retouching.
Divide multiple embodiments that the embodiment of the present invention is further detailed below.Wherein, the embodiment of the present invention is unlimited
Due to specific embodiment below.Within the scope of the unchanged main rights, implementation can appropriate be changed.If without especially saying
Bright, raw material used by the embodiment of the present invention and other chemical reagent are all commercial goods.
A kind of preparation method of the leave hand cleanser of embodiment 1, the formula of the leave hand cleanser are as follows:
| Raw material | It matches (%) |
| Benzalkonium chloride | 0.04 |
| Persimmon berry extract | 1.2 |
| Polyquaternium -37 | 0.8 |
| 1,2- hexylene glycol, glycerol | 3 |
| Caprylic/capric glyceride type Natrulon H-10 esters | 0.5 |
| Yellow chamomile essential oil | 0.15 |
| Water | 95.31 |
Specifically preparation step includes:
(1) each component is weighed by above-mentioned formula rate, taking 0.8g polyquaternium -37 to be dispersed in 1.5g weight ratio is 1:
In 21,2- hexylene glycol and glycerol compositional liquor, after deionized water then is added, 80 DEG C, homogeneous 4min are warming up to, is obtained transparent solidifying
Colloidal mixture, be then cooled to 45 DEG C it is spare；
(2) it takes 0.15g yellow chamomile essential oil dispersion into 0.5g caprylic/capric glyceride type Natrulon H-10 esters, is planted
Object essential oil transparent liquid, it is spare；
(3) take 0.04 benzalkonium chloride, 1.2g persimmon berry extract, remaining weight more multiple than the 1,2- hexylene glycol and glycerol for 1:2
With liquid, by benzalkonium chloride, persimmon berry extract, 1,2- hexylene glycol and glycerol compositional liquor, yellow chamomile essential oil and it is cooled to 45 DEG C mixed
It closes object to stir evenly together, adjusting pH is 5.5, obtains leave hand cleanser.
A kind of preparation method of the leave hand cleanser of embodiment 2, the formula of the leave hand cleanser are as follows:
| Raw material | It matches (%) |
| Benzalkonium chloride | 0.09 |
| Persimmon berry extract | 0.3 |
| Polyquaternium -37 | 1.0 |
| 1,2- hexylene glycol, butanediol | 4 |
| Caprylic/capric glyceride type Natrulon H-10 esters | 0.2 |
| Rosemary Oil | 0.05 |
| Water | 94.38 |
Specifically preparation step includes:
(1) each component is weighed by formula rate, taking 1.0g polyquaternium -37 to be dispersed in 2.0g weight ratio is 1:3's
In 1,2- hexylene glycol and butanediol compositional liquor, after deionized water then is added, 83 DEG C, homogeneous 3min are warming up to, is obtained transparent solidifying
Colloidal mixture, be then cooled to 40 DEG C it is spare；
(2) it takes the fan 0.05g essential oil that changes to be dispersed in 0.2g caprylic/capric glyceride type Natrulon H-10 esters, is planted
Object essential oil transparent liquid, it is spare；
(3) 1, the 2- hexylene glycol and butanediol compositional liquor of 0.09g benzalkonium chloride, 0.3g persimmon berry extract, residual mass are taken,
By benzalkonium chloride, persimmon berry extract, 1,2- hexylene glycol and butanediol compositional liquor, plants essential oil transparent liquid and it is cooled to 40 DEG C saturating
Bright gelatinous mixture stirs evenly together, and adjusting pH is 5.0, obtains leave hand cleanser.
A kind of preparation method of the leave hand cleanser of embodiment 3, the formula of the leave hand cleanser are as follows:
| Raw material | It matches (%) |
| Benzalkonium chloride | 0.05 |
| Persimmon berry extract | 1.0 |
| Polyquaternium -37 | 0.5 |
| 1,2- hexylene glycol, sorbierite | 2 |
| Caprylic/capric glyceride type Natrulon H-10 esters | 0.4 |
| Salvia japonica essential oil | 0.12 |
| Water | 95.93 |
Specifically preparation step includes:
(1) each component is weighed by formula rate, taking 0.5g polyquaternium -37 to be dispersed in 1.0g weight ratio is 1:1's
In 1,2- hexylene glycol and sorbierite compositional liquor, after deionized water then is added, 85 DEG C, homogeneous 5min are warming up to, is obtained transparent solidifying
Colloidal mixture, be then cooled to 45 DEG C it is spare；
(2) it takes 0.12g Salvia japonica essential oil dispersion into 0.4g caprylic/capric glyceride type Natrulon H-10 esters, is planted
Object essential oil transparent liquid, it is spare；
(3) the 1,2- hexylene glycol and sorbierite compounding of 0.05g benzalkonium chloride, 1.0g persimmon berry extract and residual mass are taken
Liquid by benzalkonium chloride, persimmon berry extract, 1,2- hexylene glycol and sorbierite compositional liquor, plants essential oil transparent liquid and is cooled to 45 DEG C
Transparent gel-form mixture stir evenly together, adjust pH be 6.0, obtain leave hand cleanser.
A kind of preparation method of the leave hand cleanser of embodiment 4, the formula of the leave hand cleanser are as follows:
| Raw material | It matches (%) |
| Benzalkonium chloride | 0.065 |
| Persimmon berry extract | 0.8 |
| Polyquaternium -37 | 0.7 |
| 1,2- hexylene glycol, sorbierite | 2.5 |
| Caprylic/capric glyceride type Natrulon H-10 esters | 0.3 |
| Lemon | 0.08 |
| Water | 95.555 |
Specifically preparation step includes:
(1) each component is weighed by formula rate, taking 0.7g polyquaternium -37 to be dispersed in 1.25g weight ratio is 2:3's
In 1,2- hexylene glycol and sorbierite compositional liquor, after deionized water then is added, 85 DEG C, homogeneous 5min are warming up to, is obtained transparent solidifying
Colloidal mixture, be then cooled to 45 DEG C it is spare；
(2) plant origin for taking 0.08 lemon to be dispersed to 0.3g caprylic/capric glyceride type Natrulon H-10 esters increases
Hold in agent, obtains plants essential oil transparent liquid, it is spare；
(3) the 1,2- hexylene glycol and sorbierite compounding of 0.065g benzalkonium chloride, 0.8g persimmon berry extract and residual mass are taken
Liquid by benzalkonium chloride, persimmon berry extract, 1,2- hexylene glycol and sorbierite compositional liquor, plants essential oil transparent liquid and is cooled to 45 DEG C
Transparent gel-form mixture stir evenly together, adjust pH be 5.2, obtain leave hand cleanser.
A kind of preparation method of the leave hand cleanser of embodiment 5, the formula of the leave hand cleanser are as follows:
| Raw material | It matches (%) |
| Benzalkonium chloride | 0.08 |
| Persimmon berry extract | 0.6 |
| Polyquaternium -37 | 0.9 |
| 1,2- hexylene glycol, glycerol | 3.5 |
| Caprylic/capric glyceride type Natrulon H-10 esters | 0.35 |
| Lavender, lemon | 0.1 |
| Water | 94.47 |
Specifically preparation step includes:
(1) each component is weighed by formula rate, taking 0.9g polyquaternium -37 to be dispersed in 1.75g weight ratio is 2:3's
In 1,2- hexylene glycol and glycerol compositional liquor, after deionized water then is added, 85 DEG C are warming up to, homogeneous 5min obtains clear gel
Shape mixture, be then cooled to 45 DEG C it is spare, the polyalcohol include weight ratio be 2:3 1,2- hexylene glycol and glycerol；
(2) the essential oil mixed liquor for the Lavender and lemon that 0.1g weight ratio is 1:1 is taken to be dispersed to 0.35g pungent
In acid/glycerol decanoate class Natrulon H-10 esters plant origin expanding material, plants essential oil transparent liquid is obtained, it is spare；
(3) take 1,2- hexylene glycol and the glycerine polyol of 0.08g benzalkonium chloride, 0.6g persimmon berry extract and residual mass multiple
With liquid, by benzalkonium chloride, persimmon berry extract, 1,2- hexylene glycol and glycerine polyol compositional liquor, the plants essential oil transparent liquid and
It is cooled to 45 DEG C of transparent gel-form mixture to stir evenly together, adjusting pH is 5.8, obtains leave hand cleanser.
Effect example
(1) sterility test (Bristol test method TM201)
The property of sample according to embodiments of the present invention, determines that microorganism whether there is using different test methods.It will
The leave hand cleanser sample that a small amount of above-described embodiment is prepared is transferred in the culture medium of suitable microorganism growth；Inoculation
Agar afterwards is cultivated 2-5 days at a suitable temperature, and any microorganism growth visually assess by operational evaluation scale, is as a result joined
Be shown in Table 1, wherein 30 DEG C of TSA: soy agar trypticase culture medium hatches 2 days detection bacteriums at 30 DEG C；
25 DEG C of SDA: Sabouraud glucose agar hatches 5 days detection fungies at 25 DEG C.
Table 1: sterility test test result
It can be seen that in each sample test process of 30 DEG C of TSA and 25 DEG C of SDA from the test result of table 1 all without micro- life
Object growth, test result show that leave hand cleanser provided in an embodiment of the present invention all has sterilization, fungistatic effect well.
(2) bactericidal effect test (European Union's EN1276 testing standard)
The leave hand cleanser that embodiment 1-5 is obtained is subjected to sterilization test according to the testing standard of EN1276.Wherein, it kills
The bacterium time test time is set as 0.5min and 5min.Test result: referring to table 2, embodiment 1-5 is by test and Log value
Reduce > 5；Wherein A: clean environment is represented；B: dirty environment is represented.
Table 2: bactericidal effect test result
According to the testing standard of EN1276, it is desirable that microorganism declines order of magnitude > 5, is shown according to upper table test result, sample
Product meet test request；And the standard is more stringenter than the requirement of national standard GB-15979-2002, tests knot by above sterilization
Fruit, it can be deduced that, the leave hand cleanser that the embodiment of the present invention is prepared can reach after acting on 30s sterilizing rate >
99.99%.
(3) deodorizing effect is tested
1. test method: placing a test sample and foul smell in closed test container；Pass through measurement test after 3min
Odor concentration in container calculates deodorization ratio.
2. being deodorized ratio (%), the following table 3 is participated in:
Table 3: deodorizing effect test data table
| Template | Ammonia | Trimethylamine | Hydrogen sulfide | Acetic acid | Isovaleric acid | Acetaldehyde | Nonenyl aldehyde |
| Embodiment 1 | 99.9 | 98.5 | 75.0 | 99.2 | 97.6 | 89.7 | 91.3 |
| Embodiment 2 | 99.7 | 98.5 | 25 | 98 | 97.6 | 42.9 | 58.1 |
| Embodiment 3 | 99.8 | 98.5 | 61.3 | 98.9 | 97.6 | 63.5 | 87.5 |
| Embodiment 4 | 99.7 | 98.5 | 42 | 98.6 | 97.6 | 53.9 | 80.1 |
| Embodiment 5 | 99.7 | 98.5 | 31 | 98.0 | 97.6 | 42.9 | 75.7 |
As can be seen from Table 3, the leave hand cleanser deodorising effect of all embodiments of the invention is all relatively good, can be high
Imitate deodorization；Wherein, embodiment 1 and embodiment 3 are more prominent.
(4) contrast test is tried out
The leave hand cleanser that embodiment 3 is obtained is as test group；(wine will be contained by certain brand non-water hand cleanser on the market
It is smart and bactericide compounded) as a control group 1, high alcohol content non-water hand cleanser 2 carry out comparison on probation as a control group.Select year
Personnel totally 75 between 20-40 years old age, experimenter and collator are respectively 25, dry skin, neutral skin in each group
It is about identical with mixing sex ratio.Experimenter uses the leave hand cleanser of test group, and collator uses the market of corresponding control group
Upper brand non-water hand cleanser；Daily using three times, using before meals in the morning, afternoon and evening respectively；No longer in addition using other during use
Hand cleanser and hand lotion；Continuous use one week.Using shown in rear Comparative result such as the following table 4 (below in percentage):
Table 4: contrast test tables of data on probation
From upper 4 test result of table, it can be seen that with the leave hand cleanser prepared of the present invention dry skin, decortication and
Stimulating item is all the non-water hand cleanser for being much better than low content alcohol and high alcohol content on the market.It, can from overall merit
To find out consumer to high-proof non-water hand cleanser degree of liking far below the leave hand cleanser that the present invention develops.
By testing and comparing on probation as a result, leave hand cleanser provided by the present invention can sterilize mark by European Union
The features such as standard, for 30s up to bactericidal effect 99.99%, deodorizing capability is strong, and mildly nonirritant to skin, does not hurt hands, and is suitble to each
Class crowd uses, and especially baby is virgin.
The above disclosure is only the preferred embodiments of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, those skilled in the art can understand all or part of the processes for realizing the above embodiment, and wants according to right of the present invention
Made equivalent variations is sought, is still belonged to the scope covered by the invention.
Claims (10)
1. a kind of leave hand cleanser, which is characterized in that including following components in percentage by weight: benzalkonium chloride 0.025-
0.10%, persimmon berry extract 0.1-2.0%, polyquaternium 0.3-1.2%, surplus is deionized water.
2. leave hand cleanser as described in claim 1, which is characterized in that the leave hand cleanser further includes weight percent
Than the polyalcohol for 1.0-5.0%.
3. leave hand cleanser as claimed in claim 2, which is characterized in that the polyalcohol further includes 1,2- hexylene glycol, sweet
One of oil, butanediol and sorbierite are a variety of.
4. leave hand cleanser as claimed in claim 1 or 2, which is characterized in that the leave hand cleanser further includes weight
The plants essential oil that the plant origin solubilizer and weight percent that percentage is 0.1-0.6% are 0.01-0.2%.
5. leave hand cleanser as claimed in claim 4, which is characterized in that the plant origin solubilizer includes octanoic acid/last of the ten Heavenly stems
Acid glyceride class Natrulon H-10 esters；The plants essential oil includes yellow chamomile essential oil, Rosemary Oil, Salvia japonica essential oil, lemon
One of essential oil and Lavender are a variety of.
6. leave hand cleanser as described in claim 1, which is characterized in that the leave hand cleanser further includes weight percent
Than the D-lactic acid for 0.001-0.005%.
7. leave hand cleanser as described in claim 1, which is characterized in that the pH of the leave hand cleanser is 5.0-6.0；
The form of the leave hand cleanser is transparent gel-form.
8. a kind of preparation method of leave hand cleanser characterized by comprising
Each component is weighed by formula rate, after mixing by polyquaternium and deionized water, 80-85 DEG C is warming up to, stirs shape
At the first mixture of transparent gel-form, be subsequently cooled to 40-45 DEG C it is spare；
Benzalkonium chloride, persimmon berry extract are added in first mixture, the second mixture is made, described second is mixed
Object after mixing evenly, obtains leave hand cleanser.
9. preparation method as claimed in claim 8, which is characterized in that be added to benzalkonium chloride, persimmon berry extract for described
While in first mixture, polyalcohol is added into first mixture, the second mixture is made.
10. preparation method as claimed in claim 8 or 9, which is characterized in that described to add benzalkonium chloride, persimmon berry extract
While in first mixture, plants essential oil transparent liquid is added into first mixture, the second mixture is made,
The preparation process of the plants essential oil transparent liquid includes: to weigh plants essential oil and plant origin expanding material by formula rate, by institute
It states plants essential oil to be dispersed in the plant origin expanding material, obtains the plants essential oil transparent liquid.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326727A (en) * | 2015-12-11 | 2016-02-17 | 饶雅琴 | Wild chrysanthemum flower washing-free hand sanitizer and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105326727A (en) * | 2015-12-11 | 2016-02-17 | 饶雅琴 | Wild chrysanthemum flower washing-free hand sanitizer and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王勇等: "天然高分子柿单宁的研究与应用", 《材料导报》 * |
| 王求淦: "《新编实用临床药物手册》", 30 September 2010, 广东科技出版社 * |
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