CN109157627A - 一种治疗风湿类风湿关节炎的中药药酒及其制备方法 - Google Patents

一种治疗风湿类风湿关节炎的中药药酒及其制备方法 Download PDF

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CN109157627A
CN109157627A CN201811337344.6A CN201811337344A CN109157627A CN 109157627 A CN109157627 A CN 109157627A CN 201811337344 A CN201811337344 A CN 201811337344A CN 109157627 A CN109157627 A CN 109157627A
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radix
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袁慧
曹君
曹君一
白艳荣
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Affiliated Hospital of Shaanxi University of Chinese Medicine
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Abstract

本发明公开了一种治疗风湿类风湿关节炎的中药药酒及其制备方法，该中药药酒由以下重量份的原料制备而成：杜仲10‑20份、桑寄生10‑20份、补骨脂5‑15份、丹参10‑20份、青风藤10‑20份、土茯苓10‑20份、羌活5‑15份、山楂3‑5份、甘草3‑5份、陈皮3‑5份、三七5‑10份、老虎泡5‑15份、六叶龙胆5‑10份、茵芋5‑10份、陈皮3‑5份、乌梅3‑6份、伸筋草5‑15份、白酒100份。本发明的药酒具有祛风除湿，温经通络，行气活血，散寒止痛，补益肝肾，强筋健骨之效，使痹症自除，改善了肢体小关节微循环，促进了炎症病灶的消退及增生病变的软化和吸收，改善了机体免疫功能。

Description

一种治疗风湿类风湿关节炎的中药药酒及其制备方法
技术领域
本发明涉及药酒制备领域，具体涉及一种治疗风湿类风湿关节炎的中药药酒及其制备方法。
背景技术
类风湿性关节炎(Rheumatoid arthritis，RA)，是一种由自身免疫障碍引致免疫系统攻击关节的长期慢性炎症，其病变特点为滑膜炎，以及由此造成的关节软骨和骨质破坏，最终导致关节畸形，如果不经过正规治疗，约75％的患者在3年内出现残废，类风湿关节炎的发病原因尚不明确，一般认为与遗传、环境、感染等因素密切相关：1、遗传因素，类风湿关节炎患者1级亲属中患病的风险较普通人群高1.5倍，孪生子研究结果显示，与类风湿关节炎相关的各种因素中，遗传因素占50％～60％，与类风湿关节炎发病相关的易感基因包括HLA-DR、PADI4和PTPN22等，2、感染因素，某些病毒和细菌感染可能作为始动因子，启动携带易感基因的个体发生免疫反应，进而导致类风湿关节炎的发病，与类风湿关节炎发病相关的病原体包括EB病毒、细小病毒B19、流感病毒及结核分枝杆菌等，3、性激素，类风湿关节炎发病率男女之比为1∶2～4，提示性激素可能参与发病，另外，女性类风湿关节炎患者在怀孕期内病情可减轻，分娩后1～3个月易复发，提示孕激素水平下降或雌-孕激素失调可能与类风湿关节炎的发病有关，4、其他因素，吸烟、寒冷、外伤及精神刺激等因素可能与类风湿关节炎的发生有关。
目前临床上治疗类风湿性关节炎药物种类很多，主要分为内服西药、外用药和内服中药三大类，内服西药长期服用后，副作用较大，对人体有一定的损害；外用药主要是贴剂和擦剂，普遍只能稍缓解症状，且易对人体表面皮肤造成伤害；内服中药包括中药制剂和抗类风湿药酒，目前，现有的抗类风湿药酒普遍存在药效低，针对性差，疗效不明显的缺陷。
发明内容
为解决上述问题，本发明提供了一种治疗风湿类风湿关节炎的中药药酒及其制备方法。
为实现上述目的，本发明采取的技术方案为：
一种治疗风湿类风湿关节炎的中药药酒，由以下重量份的原料制备而成：
杜仲10-20份、桑寄生10-20份、补骨脂5-15份、丹参10-20份、青风藤10-20份、土茯苓10-20份、羌活5-15份、山楂3-5份、甘草3-5份、陈皮3-5份、三七5-10份、老虎泡5-15份、六叶龙胆5-10份、茵芋5-10份、陈皮3-5份、乌梅3-6份、伸筋草5-15份、白酒100份。
优选地，该中药药酒由以下重量份的原料制备而成：
杜仲10份、桑寄生10份、补骨脂5份、丹参10份、青风藤10份、土茯苓10份、羌活5份、山楂3份、甘草3份、陈皮3份、三七5份、老虎泡5份、六叶龙胆5份、茵芋5份、陈皮3份、乌梅3份、伸筋草5份、白酒100份。
优选地，该中药药酒由以下重量份的原料制备而成：
杜仲20份、桑寄生20份、补骨脂15份、丹参20份、青风藤20份、土茯苓20份、羌活15份、山楂5份、甘草5份、陈皮5份、三七10份、老虎泡15份、六叶龙胆10份、茵芋10份、陈皮5份、乌梅6份、伸筋草15份、白酒100份。
优选地，该中药药酒由以下重量份的原料制备而成：
杜仲15份、桑寄生15份、补骨脂10份、丹参15份、青风藤15份、土茯苓15份、羌活10份、山楂4份、甘草4份、陈皮4份、三七7.5份、老虎泡10份、六叶龙胆7.5份、茵芋7.5份、陈皮4份、乌梅4.5份、伸筋草10份、白酒100份。
本发明还提供了上述一种治疗风湿类风湿关节炎的中药药酒的制备方法，包括如下步骤：
S1、按上述的配方称取各组分；
S2、将称取的杜仲、桑寄生、补骨脂、丹参、青风藤、土茯苓、羌活、山楂、陈皮、甘草、陈皮、三七、老虎泡、六叶龙胆、茵芋、陈皮、乌梅和伸筋草洗净沥干后，置于汽爆罐内，通入氮气至汽爆罐内压力为0.8～1.8MPa，爆破处理12～23min后，喷雾干燥，得粉体；
S3、按质量百分比为3～5％的比例向粉体内加入中性蛋白酶，按质量百分比为2～3％加入风味蛋白酶，25～35℃下酶解1～2h，过滤，得酶解液；
S4、将所得的酶解液迅速冷冻后再自然解冻，使提取物中淀粉老化沉淀；收集上清液，剩余部分离心，收集离心液体并合并于上清液中，浓缩，使得提取物呈稠膏状；
S5、将所得膏体与称取的白酒混合搅拌均匀，灌装封盖，即得。
本发明具有以下有益效果：
1)以桑寄生、青风藤、土茯苓、羌活、三七、老虎泡、六叶龙胆、茵芋和伸筋草祛风除湿、镇痛消炎、祛瘀活血、解毒消肿；补骨脂、杜仲补肝强肾、活血补血、祛瘀行血、山楂、陈皮、乌梅健脾化痰，甘草协同诸药，从而达到祛风除湿，温经通络，行气活血，散寒止痛，补益肝肾，强筋健骨之效，使痹症自除，改善了肢体小关节微循环，促进了炎症病灶的消退及增生病变的软化和吸收，改善了机体免疫功能。
2)将汽爆和酶解相结合进行原料的预处理，从而使得原料中的有效成分充分析出，大大提高了药酒的药效。
具体实施方式
下面结合具体实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明，但不以任何形式限制本发明。应当指出的是，对本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进。这些都属于本发明的保护范围。
实施例1
一种治疗风湿类风湿关节炎的中药药酒的制备方法，包括如下步骤：
S1、重量份称取：
杜仲10份、桑寄生10份、补骨脂5份、丹参10份、青风藤10份、土茯苓10份、羌活5份、山楂3份、甘草3份、陈皮3份、三七5份、老虎泡5份、六叶龙胆5份、茵芋5份、陈皮3份、乌梅3份、伸筋草5份、白酒100份。
S2、将称取的杜仲、桑寄生、补骨脂、丹参、青风藤、土茯苓、羌活、山楂、陈皮、甘草、陈皮、三七、老虎泡、六叶龙胆、茵芋、陈皮、乌梅和伸筋草洗净沥干后，置于汽爆罐内，通入氮气至汽爆罐内压力为0.8～1.8MPa，爆破处理12～23min后，喷雾干燥，得粉体；
S3、按质量百分比为3～5％的比例向粉体内加入中性蛋白酶，按质量百分比为2～3％加入风味蛋白酶，25～35℃下酶解1～2h，过滤，得酶解液；
S4、将所得的酶解液迅速冷冻后再自然解冻，使提取物中淀粉老化沉淀；收集上清液，剩余部分离心，收集离心液体并合并于上清液中，浓缩，使得提取物呈稠膏状；
S5、将所得膏体与称取的白酒混合搅拌均匀，灌装封盖，即得。
实施例2
一种治疗风湿类风湿关节炎的中药药酒的制备方法，包括如下步骤：
S1、重量份称取：
杜仲20份、桑寄生20份、补骨脂15份、丹参20份、青风藤20份、土茯苓20份、羌活15份、山楂5份、甘草5份、陈皮5份、三七10份、老虎泡15份、六叶龙胆10份、茵芋10份、陈皮5份、乌梅6份、伸筋草15份、白酒100份。
S2、将称取的杜仲、桑寄生、补骨脂、丹参、青风藤、土茯苓、羌活、山楂、陈皮、甘草、陈皮、三七、老虎泡、六叶龙胆、茵芋、陈皮、乌梅和伸筋草洗净沥干后，置于汽爆罐内，通入氮气至汽爆罐内压力为0.8～1.8MPa，爆破处理12～23min后，喷雾干燥，得粉体；
S3、按质量百分比为3～5％的比例向粉体内加入中性蛋白酶，按质量百分比为2～3％加入风味蛋白酶，25～35℃下酶解1～2h，过滤，得酶解液；
S4、将所得的酶解液迅速冷冻后再自然解冻，使提取物中淀粉老化沉淀；收集上清液，剩余部分离心，收集离心液体并合并于上清液中，浓缩，使得提取物呈稠膏状；
S5、将所得膏体与称取的白酒混合搅拌均匀，灌装封盖，即得。
实施例3
一种治疗风湿类风湿关节炎的中药药酒的制备方法，包括如下步骤：
S1、重量份称取：
杜仲15份、桑寄生15份、补骨脂10份、丹参15份、青风藤15份、土茯苓15份、羌活10份、山楂4份、甘草4份、陈皮4份、三七7.5份、老虎泡10份、六叶龙胆7.5份、茵芋7.5份、陈皮4份、乌梅4.5份、伸筋草10份、白酒100份。
S2、将称取的杜仲、桑寄生、补骨脂、丹参、青风藤、土茯苓、羌活、山楂、陈皮、甘草、陈皮、三七、老虎泡、六叶龙胆、茵芋、陈皮、乌梅和伸筋草洗净沥干后，置于汽爆罐内，通入氮气至汽爆罐内压力为0.8～1.8MPa，爆破处理12～23min后，喷雾干燥，得粉体；
S3、按质量百分比为3～5％的比例向粉体内加入中性蛋白酶，按质量百分比为2～3％加入风味蛋白酶，25～35℃下酶解1～2h，过滤，得酶解液；
S4、将所得的酶解液迅速冷冻后再自然解冻，使提取物中淀粉老化沉淀；收集上清液，剩余部分离心，收集离心液体并合并于上清液中，浓缩，使得提取物呈稠膏状；
S5、将所得膏体与称取的白酒混合搅拌均匀，灌装封盖，即得。
以上对本发明的具体实施例进行了描述。需要理解的是，本发明并不局限于上述特定实施方式，本领域技术人员可以在权利要求的范围内做出各种变化或修改，这并不影响本发明的实质内容。在不冲突的情况下，本申请的实施例和实施例中的特征可以任意相互组合。

Claims (5)

1.一种治疗风湿类风湿关节炎的中药药酒，其特征在于：由以下重量份的原料制备而成：
杜仲10-20份、桑寄生10-20份、补骨脂5-15份、丹参10-20份、青风藤10-20份、土茯苓10-20份、羌活5-15份、山楂3-5份、甘草3-5份、陈皮3-5份、三七5-10份、老虎泡5-15份、六叶龙胆5-10份、茵芋5-10份、陈皮3-5份、乌梅3-6份、伸筋草5-15份、白酒100份。
2.如权利要求1所述的一种治疗风湿类风湿关节炎的中药药酒，其特征在于：由以下重量份的原料制备而成：
杜仲10份、桑寄生10份、补骨脂5份、丹参10份、青风藤10份、土茯苓10份、羌活5份、山楂3份、甘草3份、陈皮3份、三七5份、老虎泡5份、六叶龙胆5份、茵芋5份、陈皮3份、乌梅3份、伸筋草5份、白酒100份。
3.一种治疗风湿类风湿关节炎的中药药酒，其特征在于：由以下重量份的原料制备而成：
杜仲20份、桑寄生20份、补骨脂15份、丹参20份、青风藤20份、土茯苓20份、羌活15份、山楂5份、甘草5份、陈皮5份、三七10份、老虎泡15份、六叶龙胆10份、茵芋10份、陈皮5份、乌梅6份、伸筋草15份、白酒100份。
4.一种治疗风湿类风湿关节炎的中药药酒，其特征在于：由以下重量份的原料制备而成：
杜仲15份、桑寄生15份、补骨脂10份、丹参15份、青风藤15份、土茯苓15份、羌活10份、山楂4份、甘草4份、陈皮4份、三七7.5份、老虎泡10份、六叶龙胆7.5份、茵芋7.5份、陈皮4份、乌梅4.5份、伸筋草10份、白酒100份。
5.一种治疗风湿类风湿关节炎的中药药酒的制备方法，其特征在于：包括如下步骤：
S1、按权利要求1-4任一项所述的配方称取各组分；
S2、将称取的杜仲、桑寄生、补骨脂、丹参、青风藤、土茯苓、羌活、山楂、甘草、陈皮、三七、老虎泡、六叶龙胆、茵芋、陈皮、乌梅和伸筋草洗净沥干后，置于汽爆罐内，通入氮气至汽爆罐内压力为0.8～1.8MPa，爆破处理12～23min后，喷雾干燥，得粉体；
S3、按质量百分比为3～5％的比例向粉体内加入中性蛋白酶，按质量百分比为2～3％加入风味蛋白酶，25～35℃下酶解1～2h，过滤，得酶解液；
S4、将所得的酶解液迅速冷冻后再自然解冻，使提取物中淀粉老化沉淀；收集上清液，剩余部分离心，收集离心液体并合并于上清液中，浓缩，使得提取物呈稠膏状；
S5、将所得膏体与称取的白酒混合搅拌均匀，灌装封盖，即得。
CN201811337344.6A 2018-11-07 2018-11-07 一种治疗风湿类风湿关节炎的中药药酒及其制备方法 Pending CN109157627A (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102755571A (zh) * 2012-08-08 2012-10-31 张立波 一种治疗风湿类风湿的药酒及制备工艺
KR20130071214A (ko) * 2011-12-20 2013-06-28 가천대학교 산학협력단 Ｓｋｇ 추출물을 유효성분으로 함유하는 골다공증 억제 효과를 가지는 약학적 조성물
CN104587242A (zh) * 2014-12-31 2015-05-06 胡汛 一种治疗风湿性关节炎的药酒
CN107149145A (zh) * 2017-04-29 2017-09-12 吉首大学 一种杜仲抗疲劳保健食品及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130071214A (ko) * 2011-12-20 2013-06-28 가천대학교 산학협력단 Ｓｋｇ 추출물을 유효성분으로 함유하는 골다공증 억제 효과를 가지는 약학적 조성물
CN102755571A (zh) * 2012-08-08 2012-10-31 张立波 一种治疗风湿类风湿的药酒及制备工艺
CN104587242A (zh) * 2014-12-31 2015-05-06 胡汛 一种治疗风湿性关节炎的药酒
CN107149145A (zh) * 2017-04-29 2017-09-12 吉首大学 一种杜仲抗疲劳保健食品及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
赵汝能: "《甘肃中草药资源志 （上册）》", 30 December 2004, 甘肃科学技术出版社 *

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