CN109152780B - 用于治疗结晶性关节病症的cxcr-2抑制剂 - Google Patents

用于治疗结晶性关节病症的cxcr-2抑制剂 Download PDF

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Publication number
CN109152780B
CN109152780B CN201780029205.4A CN201780029205A CN109152780B CN 109152780 B CN109152780 B CN 109152780B CN 201780029205 A CN201780029205 A CN 201780029205A CN 109152780 B CN109152780 B CN 109152780B
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compound
cxcr
pharmaceutically acceptable
inhibitor
acceptable salt
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CN109152780A (zh
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帕耶尔·纳纳瓦蒂
杰弗里·迈纳
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Ardea Biociences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780029205.4A 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂 Active CN109152780B (zh)

Priority Applications (1)

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CN202111152242.9A CN113893252A (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂

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US201662307348P 2016-03-11 2016-03-11
US62/307,348 2016-03-11
PCT/US2017/021570 WO2017156270A1 (en) 2016-03-11 2017-03-09 Cxcr-2 inhibitors for treating crystal arthropathy disorders

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CN202111152242.9A Division CN113893252A (zh) 2016-03-11 2017-03-09 用于治疗结晶性关节病症的cxcr-2抑制剂

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CN109152780B true CN109152780B (zh) 2021-10-01

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US (1) US10772886B2 (enExample)
EP (1) EP3426253A4 (enExample)
JP (2) JP6883917B2 (enExample)
CN (2) CN109152780B (enExample)
AU (1) AU2017231832B2 (enExample)
BR (1) BR112018068393A2 (enExample)
CA (1) CA3017345A1 (enExample)
CO (1) CO2018010880A2 (enExample)
MX (1) MX386771B (enExample)
WO (1) WO2017156270A1 (enExample)

Families Citing this family (7)

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CN109152780B (zh) 2016-03-11 2021-10-01 阿迪亚生命科学公司 用于治疗结晶性关节病症的cxcr-2抑制剂
AU2018334152A1 (en) * 2017-09-12 2020-04-23 Ardea Biosciences, Inc. CXCR-2 inhibitors for treating disorders
CN111727184B (zh) 2018-01-11 2022-06-28 深圳嘉科生物科技有限公司 Cxcr2拮抗剂
WO2021004531A1 (zh) * 2019-07-11 2021-01-14 南京明德新药研发有限公司 一种cxcr2拮抗剂的晶型及其应用
KR102260478B1 (ko) * 2019-08-19 2021-06-02 연세대학교 산학협력단 일나트륨 요소화물 결정 용해용 조성물
EP4161499A1 (en) * 2020-06-05 2023-04-12 Aristea Therapeutics, Inc. Use of a combination of colchicine and a cxcr-2 inhibitor for the treatment or prevention of familial mediterranean fever (fmf) and flare-ups thereof
WO2022162021A1 (en) * 2021-01-27 2022-08-04 Astrazeneca Ab Verinurad compositions and methods of use

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CN103781781A (zh) * 2011-07-12 2014-05-07 阿斯利康(瑞典)有限公司 作为趋化因子受体调节剂的n-(6-((2r,3s)-3,4-二羟基丁-2-基氧基)-2-(4-氟苄基硫基)嘧啶-4-基)-3-甲基氮杂环丁烷-1-磺酰胺

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EP2311827A1 (en) 2004-08-28 2011-04-20 AstraZeneca AB Thiopyrimidine derivative, useful as an intermediate for chemokine receptor modulators.
RU2009131454A (ru) * 2007-01-19 2011-02-27 Такеда Фармасьютикалз Норт Америка, Инк. (Us) Способы предупреждения или уменьшения числа обострений подагры с применением ингибиторов ксантиноксидоредуктазы и противовоспалительных средств
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CN103781781A (zh) * 2011-07-12 2014-05-07 阿斯利康(瑞典)有限公司 作为趋化因子受体调节剂的n-(6-((2r,3s)-3,4-二羟基丁-2-基氧基)-2-(4-氟苄基硫基)嘧啶-4-基)-3-甲基氮杂环丁烷-1-磺酰胺

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JP2019507791A (ja) 2019-03-22
JP6883917B2 (ja) 2021-06-09
CN113893252A (zh) 2022-01-07
CN109152780A (zh) 2019-01-04
JP2021121600A (ja) 2021-08-26
JP7126014B2 (ja) 2022-08-25
US10772886B2 (en) 2020-09-15
US20180235964A1 (en) 2018-08-23
EP3426253A1 (en) 2019-01-16
AU2017231832A1 (en) 2018-10-04
WO2017156270A1 (en) 2017-09-14
MX2018010946A (es) 2019-05-23
AU2017231832B2 (en) 2021-11-11
CO2018010880A2 (es) 2018-10-22
CA3017345A1 (en) 2017-09-14
EP3426253A4 (en) 2019-11-06
BR112018068393A2 (pt) 2019-01-15
MX386771B (es) 2025-03-19

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