CN109125733A - A kind of composition for the treatment of of arthritis and its application - Google Patents
A kind of composition for the treatment of of arthritis and its application Download PDFInfo
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention belongs to pharmaceutical technology fields, more particularly to a kind of composition for the treatment of of arthritis, effective component of chinese medicine or chemotherapy curative for effect will be gone to be used in combination with the Chinese medicine or its extract with promotion Drug Percutaneous Absorption effect, it is administered by transdermal topical, realize safe and effective and with strong points arthritis drug treatment, shorten treatment course, reduces chemical drug and treat side effects on the body.The composition can be applied to the drug of preparation treatment of arthritis by the beneficial effect of the composition based on the treatment of arthritis, and the pharmaceutical dosage form can be paste, spray, gelling agent, film and cataplasm.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of composition for the treatment of of arthritis and its application.
Background technique
Arthropathy, still with swelling and moving obstacle, in breaking-out and alleviates the alternate chronic course of disease, portion in addition to having pain
Even there is joint and disables and viscera function exhaustion in point patient.The existing treatment method of arthropathy has chemical drug treatment, biology to control
It treats and Chinese medicine is treated.The toxic side effect that chemical drug treats (especially Formulations for systemic administration) is strong；Biological therapy is for treatment arthropathy
Long-term treatment, somewhat expensive；Chinese medicine treatment is comparatively safe, but only can be relieved symptom, tends not to radical cure illness, and Chinese medicine at
It is point too complicated, quality control it cannot be guaranteed that.
Summary of the invention
Based on problem above, the object of the present invention is to provide a kind of composition for the treatment of of arthritis, effective component of chinese medicine or
Person's chemotherapeutics is combined, and is administered by transdermal topical, to realize safely and effectively treatment of arthritis disease.
The technical solution of the present invention is as follows:
The present invention provides a kind of composition for the treatment of of arthritis, including A and B, A are the drug for the treatment of of arthritis, and B is to promote
The Chinese medicine of Drug Percutaneous Absorption or its extract,
B is in rhizoma zingiberis, semen brassicae, Chinese prickly ash, Radix Glycyrrhizae, borneol, peppermint, cortex cinnamomi, galangal, cloves, green onion, fragrant-flowered garlic or its extract
One or more.Through applicant's actual verification, above several Chinese medicines or the arthritic drug of its extract combined treatment are used,
Cutaneous penetration, it is curative for effect.
Applicant demonstrates in the development process of the composition, and green onion, fragrant-flowered garlic and its extract also have the significant skin that promotees to seep
Effect thoroughly, meanwhile, green onion, the equal attribute acrid flavour of fragrant-flowered garlic, the component of temperature, middle benefit gas, dissipate the stasis of blood at promoting the circulation of qi, can also further improve arthritis phase
Close the diseases such as swelling pain.
Experiments verify that preferably semen brassicae, borneol, peppermint, cortex cinnamomi, galangal and one of cloves or its extract or
It is several, it is combined with the drug A for the treatment of of arthritis, the arthritic effect of transdermal medicine for treating is preferable.
Highly preferred, the B is semen brassicae, borneol and one or more of peppermint or its extract, is closed with treatment
The scorching drug A combination of section, the arthritic effect of transdermal medicine for treating are preferable.
The mass ratio of the composition for the treatment of of arthritis according to the present invention, A and B are 10-20:3-10, with this mass ratio
A, B is combined, and can play effective treatment of arthritis.
The composition for the treatment of of arthritis according to the present invention, preferably component A, A are curcumin, dihydromyricetin, tripterygium wilfordii
One or more of A prime, Celastrol, dexamethasone and hydrocortisone.
More preferably, the A is one or more of curcumin, dihydromyricetin and Celastrol, with B component
Transdermal Chinese medicine or the cooperation of its extract, can effective treatment of arthritis.
Most preferably, the A is curcumin and/or dihydromyricetin, is matched with the transdermal Chinese medicine of B component or its extract
It closes, it can more effective treatment of arthritis.
The composition for the treatment of of arthritis according to the present invention, the Chinese medical extract for promoting Drug Percutaneous Absorption are mentioned by water
Method is made, and with Chinese medical extract made from water extraction in conjunction with component A, transdermal effect is significant, drug treatment better effect.
The composition for the treatment of of arthritis according to the present invention, the group for also providing a kind of B are grouped as dosage, it is made to promote drug
The drug effect of Transdermal absorption treatment of arthritis more optimizes, and B includes following parts by weight of component: 10-20 parts of semen brassicae, peppermint 5-10
Part, 7-10 parts of borneol, 10-20 parts of cortex cinnamomi, 30-40 parts of galangal and 10-15 parts of cloves.
The composition for the treatment of of arthritis according to the present invention provides a kind of group of preferable composition of specific therapeutic effect
It is curcumin at: A, B is semen brassicae, borneol and the water extract of peppermint, and the mass ratio of A and B are 10:5, semen brassicae, borneol and thin
The mass ratio of lotus water extract is 3:1:1.
The composition for the treatment of of arthritis according to the present invention provides a kind of group of preferable composition of specific therapeutic effect
The mass ratio of the curcumin and hydrocortisone for being mass ratio 4:1 at: A, A and B are 10:3.
The composition for the treatment of of arthritis according to the present invention provides a kind of group of preferable composition of specific therapeutic effect
The mass ratio of curcumin, dihydromyricetin and the Celastrol for being mass ratio 4:1:2 at: A, A and B are 20:3.
The composition that the present invention provides any treatment of arthritis is preparing the application in medicament for treating arthritis.Root
According to the application, the pharmaceutical dosage form of the preparation is paste, spray, gelling agent, film and cataplasm.
The invention has the benefit that
The present invention provides a kind of composition for the treatment of of arthritis, by effective component of chinese medicine or chemotherapy curative for effect to go with
It is used in combination with the Chinese medicine or its extract for promoting Drug Percutaneous Absorption effect, is administered by transdermal topical, realize that safety has
Effect and arthritis drug with strong points treatment, shorten treatment course, reduce chemical drug and treat side effects on the body.
The composition can be applied to preparation treatment joint by the beneficial effect of the composition based on the treatment of arthritis
Scorching drug, the pharmaceutical dosage form can be paste, spray, gelling agent, film and cataplasm.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
With 1 part for 1g in following embodiment.
Embodiment 1
The present invention provides a kind of composition for the treatment of of arthritis, including A and B, A are the drug for the treatment of of arthritis, and B is to promote
The Chinese medicine of Drug Percutaneous Absorption or its extract,
The mass ratio of A and B is 10:10；
A is dexamethasone；
B is the water extract of rhizoma zingiberis, semen brassicae and green onion that mass ratio is 1:3:1.
Embodiment 2
The present invention provides a kind of composition for the treatment of of arthritis, including A and B, A are the drug for the treatment of of arthritis, and B is to promote
The Chinese medicine of Drug Percutaneous Absorption or its extract,
The mass ratio of A and B is 15:8；
A is triptolide, Celastrol and hydrocortisone；
B is Radix Glycyrrhizae.
Embodiment 3
The present invention provides a kind of composition for the treatment of of arthritis, including A and B, A are the drug for the treatment of of arthritis, and B is to promote
The Chinese medicine of Drug Percutaneous Absorption or its extract,
The mass ratio of A and B is 20:10；
A is hydrocortisone；
B is the water extract of semen brassicae and fragrant-flowered garlic, and the mass ratio of semen brassicae and fragrant-flowered garlic water extract is 3:2.
Embodiment 4
The present invention provides a kind of composition for the treatment of of arthritis, and A is curcumin, B be mass ratio be 3:1:1 semen brassicae,
The mass ratio of the water extract of borneol and peppermint, A and B are 10:5.
Embodiment 5
The present invention provides a kind of composition for the treatment of of arthritis, and A is curcumin, and B is the mixing of borneol and Peppermint Water extract
The mass ratio of object, A and B are 17:11.
Embodiment 6
The present invention provides a kind of composition for the treatment of of arthritis, and A is the curcumin and hydrocortisone of mass ratio 4:1, B packet
Include following parts by weight of component: 10 parts of semen brassicae, 10 parts of peppermint, 7 parts of borneol, 20 parts of cortex cinnamomi, 30 parts of galangal and 15 parts of cloves；
The mass ratio of A and B is 10:3.
Embodiment 7
The present invention provides a kind of composition for the treatment of of arthritis, curcumin that A is mass ratio 4:1:2, dihydromyricetin and
Celastrol, B include following parts by weight of component: 20 parts of semen brassicae, 5 parts of peppermint, 10 parts of borneol, 10 parts of cortex cinnamomi, galangal 40
Part and 10 parts of cloves；
The mass ratio of A and B is 20:3.
Embodiment 8
The present invention provides a kind of composition for the treatment of of arthritis, and A is dihydromyricetin, and B includes following parts by weight of component: white
15 parts of mustard seed, 7 parts of peppermint, 9 parts of borneol, 15 parts of cortex cinnamomi, 35 parts of galangal and 12 parts of cloves；
The mass ratio of A and B is 12:7.
Embodiment 9
The present invention provides a kind of composition for the treatment of of arthritis, and A is the mixture of matter curcumin and dihydromyricetin, B packet
Include Chinese prickly ash；
The mass ratio of A and B is 12:7.
All compositions of above embodiments 1-8 are used equally for the conventional dose of preparation treatment of arthritis, such as paste, by spraying
Agent, gelling agent, film and cataplasm etc..
Experiment
Transdermal paste is made with 1-9 any combination object of the embodiment of the present invention and gives arthritic's smearing use, carries out this
The efficacy experiment of inventive composition is verified.
Arthritic is given with the separately made paste of component A in each composition of embodiment 1-9 and smears use, as right
Ratio is denoted as comparative example 1-9.
Every embodiment and comparative example arthritis volunteer is 20, and each embodiment and comparative example volunteer age, gender
There is statistical significance to final experimental result with conditions.
Application method is according to symptom weight, and each smearing one is inferior to affected part sooner or later, with a month as a treatment course, with joint
Inflammation shape completely disappears to cure, symptom mitigate be it is effective, it is effective and to cure the sum of percentage be total effective rate.
Table 1 is shown as experimental result
Table 1
A, B of the invention are applied in combination it can be seen from the above Contrast on effect, and the total effective rate for the treatment of of arthritis is 85%
Even up to 95%, without the paste used with B combination A, the effective percentage for the treatment of of arthritis is only 50% or so, it is seen that with this
The composition treatment of arthritis of invention plays efficiency and greatly improves, and with the semen brassicae of specific components, peppermint, borneol, cortex cinnamomi, height
Galanga and cloves are transdermal component, and experiment total effective rate stably reaches 90% or more.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of composition for the treatment of of arthritis, which is characterized in that including A and B, A is the drug for the treatment of of arthritis, and B is to promote
The Chinese medicine of Drug Percutaneous Absorption or its extract,
B is one in rhizoma zingiberis, semen brassicae, Chinese prickly ash, Radix Glycyrrhizae, borneol, peppermint, cortex cinnamomi, galangal, cloves, green onion, fragrant-flowered garlic or its extract
Kind is several.
2. the composition for the treatment of of arthritis according to claim 1, which is characterized in that the mass ratio of A and B is 10-20:3-
10。
3. the composition for the treatment of of arthritis according to claim 1, which is characterized in that A be curcumin, dihydromyricetin,
One or more of triptolide, Celastrol, dexamethasone and hydrocortisone.
4. the composition for the treatment of of arthritis according to claim 1, which is characterized in that the promotion Drug Percutaneous Absorption
Chinese medical extract is made by water extraction.
5. the composition for the treatment of of arthritis according to claim 1, which is characterized in that B includes following parts by weight of component: white
10-20 parts of mustard seed, 5-10 parts of peppermint, 7-10 parts of borneol, 10-20 parts of cortex cinnamomi, 30-40 parts of galangal and 10-15 parts of cloves.
6. the composition for the treatment of of arthritis according to claim 1, which is characterized in that A is curcumin, and B is semen brassicae, ice
The mass ratio of the water extract of piece and peppermint, A and B are 10:5, and the mass ratio of semen brassicae, borneol and Peppermint Water extract is 3:1:1.
7. the composition for the treatment of of arthritis according to claim 5, which is characterized in that A be mass ratio 4:1 curcumin and
The mass ratio of hydrocortisone, A and B are 10:3, and the mass ratio of curcumin and hydrocortisone is 4:1.
8. the composition for the treatment of of arthritis according to claim 5, which is characterized in that A is the turmeric of mass ratio 4:1:2
The mass ratio of element, dihydromyricetin and Celastrol, A and B are 20:3.
9. any composition of claim 1-8 is preparing the application in medicament for treating arthritis.
10. application according to claim 9, which is characterized in that the pharmaceutical dosage form is paste, spray, gelling agent, film
Agent and cataplasm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811273670.5A CN109125733A (en) | 2018-10-30 | 2018-10-30 | A kind of composition for the treatment of of arthritis and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811273670.5A CN109125733A (en) | 2018-10-30 | 2018-10-30 | A kind of composition for the treatment of of arthritis and its application |
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| Publication Number | Publication Date |
|---|---|
| CN109125733A true CN109125733A (en) | 2019-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811273670.5A Pending CN109125733A (en) | 2018-10-30 | 2018-10-30 | A kind of composition for the treatment of of arthritis and its application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112294782A (en) * | 2020-11-12 | 2021-02-02 | 成都植宇生物科技有限公司 | Pharmaceutical composition of dihydromyricetin and application |
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| CN112294782A (en) * | 2020-11-12 | 2021-02-02 | 成都植宇生物科技有限公司 | Pharmaceutical composition of dihydromyricetin and application |
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