CN109106915A - A kind of anti-inflammatory cream and preparation method thereof of releiving - Google Patents

A kind of anti-inflammatory cream and preparation method thereof of releiving Download PDF

Info

Publication number
CN109106915A
CN109106915A CN201811268879.2A CN201811268879A CN109106915A CN 109106915 A CN109106915 A CN 109106915A CN 201811268879 A CN201811268879 A CN 201811268879A CN 109106915 A CN109106915 A CN 109106915A
Authority
CN
China
Prior art keywords
parts
inflammatory
releiving
skin
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201811268879.2A
Other languages
Chinese (zh)
Inventor
何凤姣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201811268879.2A priority Critical patent/CN109106915A/en
Publication of CN109106915A publication Critical patent/CN109106915A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses the anti-inflammatory creams of releiving of one of anti-inflammatory drug preparation technical field, including raw material below: Jojoba oil content, reed fragrant plant oil, albolene, ophiopogonpolysaccharide, methyl glucoside sesquistearate, methyl glucoside sesquistearate, dimethicone, pseudoephedrine hydrochloride, carbomer, polyethylene glycol, anti-inflammatory plant extracts, deionized water, niacinamide, skin conditioner, antiallergic are releived composition, Trimethoprim, oil phase thickeners.The each component scientific compatibility of the present invention, reasonable formula, property is mildly non-stimulated, can effectively calm sensitive skin, fading redness, red capillary, trace such as are itched at the malaise symptoms, sensitive skin, fatigue of releiving are repaired, and supplements skin moisture content, improve the moisture-retaining capacity and autoimmunity of skin cuticula, improve sensitive skin quality, restore the natural physiology rhythm of skin, resists and injured caused by outer bound pair skin.

Description

A kind of anti-inflammatory cream and preparation method thereof of releiving
Technical field
The present invention relates to anti-inflammatory drug preparation technical field, specifically a kind of anti-inflammatory cream and preparation method thereof of releiving.
Background technique
Chafing is due to the inflammatory reaction that bacterium invades human skin and occurs, and the bacterium of invasion is more generally gold Color staphylococcus, A group streptococcus, Pseudomonas aeruginosa, vibrio parahaemolytious etc..So as to cause part may occur in which it is red, swollen, hot, pain and Dysfunction, bacterium and toxin, which enter blood circulation, when serious can cause toxaemia or septicemia.
For at present, common solution skin problem method is mostly to take drugs and smear corresponding ointments drug, Such as: Loratadine, vitamin C, amoxicillin and clavulanate potassium dispersible tablet or smearing mupirocin ointment etc. are taken, it is this kind of Drug has positive effect for traditional skin problem really.But many ointments drugs are inevitably irritating, easily lead to skin and go out The anaphylaxis abnormal phenomenon such as existing shouting pain, redness.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-inflammatory creams and preparation method thereof of releiving, to solve in above-mentioned background technique The problem of proposition.
To achieve the above object, the invention provides the following technical scheme:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 0.5-2.5 parts of jojoba oil, reed fragrant plant oil 3-9 parts, 4-10 parts of albolene, 3-7 parts of ophiopogonpolysaccharide, 2-8 parts of methyl glucoside sesquistearate, methyl glucoside 2-6 parts of sesquistearate, 4-8 parts of dimethicone, 0.5-3.5 parts of pseudoephedrine hydrochloride, 1-5 parts of carbomer, polyethylene glycol 2-6 parts, plant extracts 4-12 parts anti-inflammatory, 10-20 parts of deionized water, 3-9 parts of niacinamide, 5-15 parts of skin conditioner, antiallergic It releives 3-7 parts of composition, 3-7 parts of Trimethoprim, 6-14 parts of oil phase thickeners.
As a further solution of the present invention: including following raw material in parts by weight: 1-2 parts of jojoba oil, reed fragrant plant 5-7 parts oily, 5-9 parts of albolene, 4-6 parts of ophiopogonpolysaccharide, 3-7 parts of methyl glucoside sesquistearate, methyl glucoside 3-5 parts of glycosides sesquistearate, 5-7 parts of dimethicone, 1-3 parts of pseudoephedrine hydrochloride, 2-4 parts of carbomer, polyethylene glycol 3-5 Part, plant extracts 6-10 parts anti-inflammatory, 12-18 parts of deionized water, 5-7 parts of niacinamide, 7-13 parts of skin conditioner, antiallergic are releived 4-6 parts of composition, 4-6 parts of Trimethoprim, 8-12 parts of oil phase thickeners.
As further scheme of the invention: including following raw material in parts by weight: 1.5 parts of jojoba oil, reed Fragrant plant oil 6 parts, 7 parts of albolene, 5 parts of ophiopogonpolysaccharide, 5 parts of methyl glucoside sesquistearate, methyl glucoside sesquialter 4 parts of stearate, 6 parts of dimethicone, 2 parts of pseudoephedrine hydrochloride, 3 parts of carbomer, 4 parts of polyethylene glycol, anti-inflammatory plant extract 8 parts of object, 15 parts of deionized water, 6 parts of niacinamide, 10 parts of skin conditioner, antiallergic releive 5 parts of composition, 5 parts of Trimethoprim, 10 parts of oil phase thickeners.
As the present invention further scheme: the skin conditioner is by tocopherol acetate, hydrolecithin, red Bisabol is formed according to mass ratio 1:1:1, and the Shu Min releives composition by Astragalus membranacus root extract, the extraction of Rhizoma Atractylodis Macrocephalae rhizome Object, Baical Skullcap root P.E, german chamomile flower extract, houttuynia extract and licorice root extract are according to mass ratio 1:1:1:1:1:1 group At the anti-inflammatory plant extracts includes menthol, chamomile and curcuma zedoary, and is formed according to mass ratio 1:2:1.
As further scheme of the invention: the Trimethoprim is sulfamethoxazole, and the oil phase thickeners are It is made of ring five dimethyl silicone polymer, distearyl dimethylammonium hectorite and propylene glycol carbonate.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A are warming up to 80~85 DEG C, keep the temperature 5~10min, then cool to 40~45 DEG C, and antiallergic is added It releives composition and anti-inflammatory plant extracts, stirs 5~10min, discharge spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 10~15min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 35~50min, then high speed homogenization, vacuumizes and disappears Bubble；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
As the present invention further scheme: the step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts With revolving speed 600-800r/min stirring.
As further scheme of the invention: the step S4 emulsion pot needs first to stir with 200-300r/min before opening Mix 10~20min.
Compared with prior art, the beneficial effects of the present invention are: pseudoephedrine hydrochloride and niacinamide etc. that the present invention is added The germ at inflammation to skin can be accelerated to have with vitamin effect, and with the cooperation of mutually promoting of anti-inflammatory plant extracts Effect is killed, and the Trimethoprim being added can effectively enhance the effect of germ processing；Antiallergic composition of releiving can be effectively prevent Skin is to the allergic conditions of the sterilization cream, and each component scientific compatibility, reasonable formula, property is mildly non-stimulated, can be effective Calm sensitivity skin, fading redness, red capillary, trace such as are itched at the malaise symptoms, repair sensitivity skin, fatigue of releiving, and supplement skin Moisture content improves the moisture-retaining capacity and autoimmunity of skin cuticula, improves sensitive skin quality, restores the natural physiology rhythm of skin Rule is resisted and is injured caused by outer bound pair skin.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment one:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 0.5 part of jojoba oil, 3 parts of reed fragrant plant oil, 4 parts of albolene, 3 parts of ophiopogonpolysaccharide, 2 parts of methyl glucoside sesquistearate, methyl glucoside sesquistearate 2 Part, 4 parts of anti-inflammatory plant extracts, is gone 4 parts of dimethicone, 0.5 part of pseudoephedrine hydrochloride, 1 part of carbomer, 2 parts of polyethylene glycol 10 parts of ionized water, 3 parts of niacinamide, 5 parts of skin conditioner, antiallergic are releived 3 parts of composition, 3 parts of Trimethoprim, oil phase thickeners 6 parts.
The skin conditioner is by tocopherol acetate, hydrolecithin, bisabolol according to mass ratio 1:1:1 group It is mentioned at, Shu Min composition of releiving by Astragalus membranacus root extract, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, Flos Chrysanthemi Object, houttuynia extract and licorice root extract is taken to form according to mass ratio 1:1:1:1:1:1, the anti-inflammatory plant extracts packet Menthol, chamomile and curcuma zedoary are included, and is formed according to mass ratio 1:2:1.
The Trimethoprim is sulfamethoxazole, and the oil phase thickeners are by ring five dimethyl silicone polymer, two hard Rouge dimethylammonium hectorite and propylene glycol carbonate composition, mass ratio 1:2:1.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A, are warming up to 80 DEG C, keep the temperature 5min, then cool to 40 DEG C, be added antiallergic releive composition and Anti-inflammatory plant extracts stirs 5min, discharges spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 10min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 35min, then high speed homogenization, vacuumizes defoaming；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
The step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts with revolving speed 60r/min stirring.
The step S4 emulsion pot needs first to stir 10min with 200r/min before opening.
Embodiment two:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 1 part of jojoba oil, reed fragrant plant are 5 parts oily, white 5 parts of vaseline, 4 parts of ophiopogonpolysaccharide, 3 parts of methyl glucoside sesquistearate, methyl glucoside sesquistearate 3 Part, 5 parts of dimethicone, 1 part of pseudoephedrine hydrochloride, 2 parts of carbomer, 3 parts of polyethylene glycol, 6 parts of anti-inflammatory plant extracts, go from 12 parts of sub- water, 5 parts of niacinamide, 7 parts of skin conditioner, antiallergic are releived 4 parts of composition, 4 parts of Trimethoprim, oil phase thickeners 8 Part.
The skin conditioner is by tocopherol acetate, hydrolecithin, bisabolol according to mass ratio 1:1:1 group It is mentioned at, Shu Min composition of releiving by Astragalus membranacus root extract, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, Flos Chrysanthemi Object, houttuynia extract and licorice root extract is taken to form according to mass ratio 1:1:1:1:1:1, the anti-inflammatory plant extracts packet Menthol, chamomile and curcuma zedoary are included, and is formed according to mass ratio 1:2:1.
The Trimethoprim is sulfamethoxazole, and the oil phase thickeners are by ring five dimethyl silicone polymer, two hard Rouge dimethylammonium hectorite and propylene glycol carbonate composition, mass ratio 1:2:1.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A, are warming up to 85 DEG C, keep the temperature 10min, then cool to 45 DEG C, be added antiallergic releive composition and Anti-inflammatory plant extracts stirs 10min, discharges spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 15min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 50min, then high speed homogenization, vacuumizes defoaming；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
The step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts with revolving speed 650r/min stirring.
The step S4 emulsion pot needs first to stir 20min with 300r/min before opening.
Embodiment three:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 1.5 parts of jojoba oil, 6 parts of reed fragrant plant oil, 7 parts of albolene, 5 parts of ophiopogonpolysaccharide, 5 parts of methyl glucoside sesquistearate, methyl glucoside sesquistearate 4 Part, 6 parts of dimethicone, 2 parts of pseudoephedrine hydrochloride, 3 parts of carbomer, 4 parts of polyethylene glycol, 8 parts of anti-inflammatory plant extracts, go from 15 parts of sub- water, 6 parts of niacinamide, 10 parts of skin conditioner, antiallergic are releived 5 parts of composition, 5 parts of Trimethoprim, oil phase thickeners 10 parts.
The skin conditioner is by tocopherol acetate, hydrolecithin, bisabolol according to mass ratio 1:1:1 group It is mentioned at, Shu Min composition of releiving by Astragalus membranacus root extract, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, Flos Chrysanthemi Object, houttuynia extract and licorice root extract is taken to form according to mass ratio 1:1:1:1:1:1, the anti-inflammatory plant extracts packet Menthol, chamomile and curcuma zedoary are included, and is formed according to mass ratio 1:2:1.
The Trimethoprim is sulfamethoxazole, and the oil phase thickeners are by ring five dimethyl silicone polymer, two hard Rouge dimethylammonium hectorite and propylene glycol carbonate composition, mass ratio 1:2:1.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A, are warming up to 80 DEG C, keep the temperature 5min, then cool to 40 DEG C, be added antiallergic releive composition and Anti-inflammatory plant extracts stirs 5min, discharges spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 10min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 35min, then high speed homogenization, vacuumizes defoaming；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
The step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts with revolving speed 700r/min stirring.
The step S4 emulsion pot needs first to stir 20min with 300r/min before opening.
Example IV:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 2 parts of jojoba oil, reed fragrant plant are 7 parts oily, white 9 parts of vaseline, 6 parts of ophiopogonpolysaccharide, 7 parts of methyl glucoside sesquistearate, methyl glucoside sesquistearate 5 Part, 10 parts of anti-inflammatory plant extracts, is gone 7 parts of dimethicone, 3 parts of pseudoephedrine hydrochloride, 4 parts of carbomer, 5 parts of polyethylene glycol 18 parts of ionized water, 7 parts of niacinamide, 13 parts of skin conditioner, antiallergic releive 6 parts of composition, 6 parts of Trimethoprim, oil mutually thicken 12 parts of agent.
The skin conditioner is by tocopherol acetate, hydrolecithin, bisabolol according to mass ratio 1:1:1 group It is mentioned at, Shu Min composition of releiving by Astragalus membranacus root extract, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, Flos Chrysanthemi Object, houttuynia extract and licorice root extract is taken to form according to mass ratio 1:1:1:1:1:1, the anti-inflammatory plant extracts packet Menthol, chamomile and curcuma zedoary are included, and is formed according to mass ratio 1:2:1.
The Trimethoprim is sulfamethoxazole, and the oil phase thickeners are by ring five dimethyl silicone polymer, two hard Rouge dimethylammonium hectorite and propylene glycol carbonate composition, mass ratio 1:2:1.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A, are warming up to 80 DEG C, keep the temperature 5min, then cool to 40 DEG C, be added antiallergic releive composition and Anti-inflammatory plant extracts stirs 5min, discharges spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 10min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 35min, then high speed homogenization, vacuumizes defoaming；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
The step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts with revolving speed 750r/min stirring.
The step S4 emulsion pot needs first to stir 10min with 200r/min before opening.
Embodiment five:
A kind of anti-inflammatory cream of releiving, including following raw material in parts by weight: 2.5 parts of jojoba oil, 9 parts of reed fragrant plant oil, 10 parts of albolene, 7 parts of ophiopogonpolysaccharide, 8 parts of methyl glucoside sesquistearate, methyl glucoside sesquistearate 6 parts, 8 parts of dimethicone, 3.5 parts of pseudoephedrine hydrochloride, 5 parts of carbomer, 6 parts of polyethylene glycol, 12 parts of anti-inflammatory plant extracts, 20 parts of deionized water, 9 parts of niacinamide, 15 parts of skin conditioner, antiallergic releive 7 parts of composition, 7 parts of Trimethoprim, oil mutually increase Thick dose 14 parts.
The skin conditioner is by tocopherol acetate, hydrolecithin, bisabolol according to mass ratio 1:1:1 group It is mentioned at, Shu Min composition of releiving by Astragalus membranacus root extract, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, Flos Chrysanthemi Object, houttuynia extract and licorice root extract is taken to form according to mass ratio 1:1:1:1:1:1, the anti-inflammatory plant extracts packet Menthol, chamomile and curcuma zedoary are included, and is formed according to mass ratio 1:2:1.
The Trimethoprim is sulfamethoxazole, and the oil phase thickeners are by ring five dimethyl silicone polymer, two hard Rouge dimethylammonium hectorite and propylene glycol carbonate composition, mass ratio 1:2:1.
A kind of preparation method of the anti-inflammatory cream of releiving, comprising the following steps:
S1: each component is weighed；
S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% 200 mesh mistake of deionized water stirring and dissolving Prefabrication A is made in filter；
S3: remaining deionized water being added in emulsion pot, starts to stir, and jojoba oil, reed fragrant plant oil, Bai Fanshi is added Woods, dimethicone and prefabrication A, are warming up to 85 DEG C, keep the temperature 10min, then cool to 45 DEG C, be added antiallergic releive composition and Anti-inflammatory plant extracts stirs 10min, discharges spare；
S4: emulsion pot is opened, by niacinamide, methyl glucoside sesquistearate, methyl glucoside times semi-solid fat Acid esters and polyethylene glycol are added in emulsion pot, then skin conditioner, Trimethoprim, oil phase thickeners is added in homogeneous, and homogeneous stirs Mix 10~15min；
S5: water phase is slowly pumped into emulsion pot after filtering, exhausts in 50min, then high speed homogenization, vacuumizes defoaming；
S6: sampling inspection, after Material inspection is qualified, discharging is got product.
The step S3 is added antiallergic and releives composition and anti-inflammatory plant extracts with revolving speed 800r/min stirring.
The step S4 emulsion pot needs first to stir 20min with 300r/min before opening.
Comparative example 1
Compared with Example 3, pseudoephedrine hydrochloride is free of, other are same as Example 3.
Comparative example 2
Compared with Example 3, not niacinamide-containing, other are same as Example 3.
Comparative example 3
Compared with Example 3, pseudoephedrine hydrochloride and niacinamide are free of, other are same as Example 3.
Choose mouse 80 between 20-30 grams of weight, mouse be divided into 4 groups, then rat hindleg plantar (measurement Position) 0.05 milliliter of egg white of subcutaneous injection/only, make its inflammation swelling, after ten minutes, vola pedis applies after the mouse of each group respectively The anti-inflammatory cream for wiping comparative example 1-3 and the preparation of embodiment three, observes the swelling situation of vola pedis after mouse.Itself the result is as follows:
As can be seen from the above table, the anti-inflammatory cream of releiving that prepared by embodiment three takes effect faster in anti-inflammatory effects, can be effective It releives pain.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.

Claims (8)

1. a kind of anti-inflammatory cream of releiving, which is characterized in that including following raw material in parts by weight: jojoba oil 0.5-2.5 Part, 3-9 parts of reed fragrant plant oil, 4-10 parts of albolene, 3-7 parts of ophiopogonpolysaccharide, 2-8 parts of methyl glucoside sesquistearate, first 2-6 parts of base glucoside sesquistearate, 4-8 parts of dimethicone, 0.5-3.5 parts of pseudoephedrine hydrochloride, carbomer 1-5 Part, 2-6 parts of polyethylene glycol, plant extracts 4-12 parts anti-inflammatory, 10-20 parts of deionized water, 3-9 parts of niacinamide, skin conditioner 5-15 parts, antiallergic releives 3-7 parts of composition, 3-7 parts of Trimethoprim, 6-14 parts of oil phase thickeners.
2. anti-inflammatory cream of releiving according to claim 1, which is characterized in that including following raw material in parts by weight: 1-2 parts of jojoba oil, 5-7 parts of reed fragrant plant oil, 5-9 parts of albolene, 4-6 parts of ophiopogonpolysaccharide, methyl glucoside sesquialter stearic acid 3-7 parts of ester, 3-5 parts of methyl glucoside sesquistearate, 5-7 parts of dimethicone, 1-3 parts of pseudoephedrine hydrochloride, card wave 2-4 parts of nurse, 3-5 parts of polyethylene glycol, plant extracts 6-10 parts anti-inflammatory, 12-18 parts of deionized water, 5-7 parts of niacinamide, skin tune Agent 7-13 parts of reason, antiallergic are releived 4-6 parts of composition, 4-6 parts of Trimethoprim, 8-12 parts of oil phase thickeners.
3. anti-inflammatory cream of releiving according to claim 1, which is characterized in that including following raw material in parts by weight: 1.5 parts of jojoba oil, 6 parts of reed fragrant plant oil, 7 parts of albolene, 5 parts of ophiopogonpolysaccharide, 5 parts of methyl glucoside sesquistearate, 4 parts of methyl glucoside sesquistearate, 6 parts of dimethicone, 2 parts of pseudoephedrine hydrochloride, 3 parts of carbomer, polyethylene glycol 4 Part, 8 parts of anti-inflammatory plant extracts, 15 parts of deionized water, 6 parts of niacinamide, 10 parts of skin conditioner, antiallergic releive 5 parts of composition, 5 parts of Trimethoprim, 10 parts of oil phase thickeners.
4. anti-inflammatory cream of releiving according to claim 1, which is characterized in that the skin conditioner is by tocopheryl acetate Ester, hydrolecithin, bisabolol are formed according to mass ratio 1:1:1, and Shu Min composition of releiving is mentioned by Astragalus membranacus root Take object, Rhizoma Atractylodis Macrocephalae rhizome extract, Baical Skullcap root P.E, german chamomile flower extract, houttuynia extract and licorice root extract according to matter Amount is formed than 1:1:1:1:1:1, and the anti-inflammatory plant extracts includes menthol, chamomile and curcuma zedoary, and according to mass ratio 1: 2:1 composition.
5. anti-inflammatory cream of releiving according to claim 1, which is characterized in that the Trimethoprim is sulfamethoxazole, The oil phase thickeners are to be made of ring five dimethyl silicone polymer, distearyl dimethylammonium hectorite and propylene glycol carbonate.
6. a kind of preparation method of anti-inflammatory cream of releiving a method as claimed in any one of claims 1 to 5, which is characterized in that including following step It is rapid: S1: to weigh each component；S2: weighed pseudoephedrine hydrochloride, carbomer, ophiopogonpolysaccharide, 50% deionized water stirring it is molten The filtering of 200 mesh is solved, prefabrication A is made；S3: remaining deionized water being added in emulsion pot, starts to stir, and Jojoba is added Oil, reed fragrant plant oil, albolene, dimethicone and prefabrication A are warming up to 80~85 DEG C, keep the temperature 5~10min, then cool to 40 ~45 DEG C, antiallergic is added and releives composition and anti-inflammatory plant extracts, stirs 5~10min, discharges spare；S4: emulsification is opened Cream is added in niacinamide, methyl glucoside sesquistearate, methyl glucoside sesquistearate and polyethylene glycol by pot Change in pot, then be uniformly added into skin conditioner, Trimethoprim, oil phase thickeners, homogeneous stirs 10~15min；S5: water phase It is slowly pumped into emulsion pot after filtering, is exhausted in 35~50min, then high speed homogenization, vacuumizes defoaming；S6: sampling inspection, material After body inspection is qualified, discharging is got product.
7. the preparation method of anti-inflammatory cream of releiving according to claim 6, which is characterized in that antiallergic is added in the step S3 Composition and anti-inflammatory plant extracts releive with revolving speed 600-800r/min stirring.
8. the preparation method of anti-inflammatory cream of releiving according to claim 6, which is characterized in that the step S4 emulsion pot is opened It needs first to stir 10~20min with 200-300r/min before opening.
CN201811268879.2A 2018-10-29 2018-10-29 A kind of anti-inflammatory cream and preparation method thereof of releiving Withdrawn CN109106915A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811268879.2A CN109106915A (en) 2018-10-29 2018-10-29 A kind of anti-inflammatory cream and preparation method thereof of releiving

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811268879.2A CN109106915A (en) 2018-10-29 2018-10-29 A kind of anti-inflammatory cream and preparation method thereof of releiving

Publications (1)

Publication Number Publication Date
CN109106915A true CN109106915A (en) 2019-01-01

Family

ID=64855478

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811268879.2A Withdrawn CN109106915A (en) 2018-10-29 2018-10-29 A kind of anti-inflammatory cream and preparation method thereof of releiving

Country Status (1)

Country Link
CN (1) CN109106915A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110327267A (en) * 2019-08-14 2019-10-15 谢娟 A kind of skin energy cream and preparation method thereof
CN114028299A (en) * 2021-12-20 2022-02-11 浙江卡莱卡生物科技有限公司 Fibrous ointment for wound surface nursing and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106726994A (en) * 2016-12-29 2017-05-31 广州市中通生化制品有限公司 A kind of antiallergic is releived cream and preparation method thereof
CN108042463A (en) * 2017-11-30 2018-05-18 东莞沃莱施日用品有限公司 A kind of elastic force beauty body lotion and preparation method thereof
CN108464968A (en) * 2018-05-22 2018-08-31 广东药科大学 A kind of infant's anti-inflammatory cream and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106726994A (en) * 2016-12-29 2017-05-31 广州市中通生化制品有限公司 A kind of antiallergic is releived cream and preparation method thereof
CN108042463A (en) * 2017-11-30 2018-05-18 东莞沃莱施日用品有限公司 A kind of elastic force beauty body lotion and preparation method thereof
CN108464968A (en) * 2018-05-22 2018-08-31 广东药科大学 A kind of infant's anti-inflammatory cream and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110327267A (en) * 2019-08-14 2019-10-15 谢娟 A kind of skin energy cream and preparation method thereof
CN114028299A (en) * 2021-12-20 2022-02-11 浙江卡莱卡生物科技有限公司 Fibrous ointment for wound surface nursing and preparation method thereof

Similar Documents

Publication Publication Date Title
CN103976907B (en) A kind of cosmetics comprising the compositionss with antiallergic effect of releiving, its preparation method and application
CN110755321A (en) Composition for quick allergy relief and preparation method and application thereof
CN103961294A (en) Rehmannia extracting solution as well as preparation method and application thereof
CN109106915A (en) A kind of anti-inflammatory cream and preparation method thereof of releiving
CN111728907A (en) Soothing and anti-allergy composition, preparation method thereof and application thereof in cosmetics
Manouchehri et al. Polycystic ovaries and herbal remedies: A systematic review
CN106619358A (en) Skincare preparation with easing, anti-allergy and repairing effects
CN108653129A (en) A kind of dressing for skin including the potent antiallergic composition of natural plants
CN104027280B (en) A kind of delay aging drug compositions and the application in cosmetics thereof
Ayeni et al. Cytotoxic and antioxidant activities of selected South African medicinal plants
Rodda et al. Investigation on anti-inflammatory property of Basella alba Linn leaf extract
CN107260612B (en) Chloasma removing composition, application, compound preparation and preparation method
KR102025859B1 (en) Cosmetic or phamaceutical composition comprising herb extract and method for preparing the same
CN102772644B (en) Traditional Chinese medicine composition and preparation with detumescence repairing function and preparation method thereof
CN108464968A (en) A kind of infant's anti-inflammatory cream and preparation method thereof
Bekele et al. Antidiabetic activity and phytochemical screening of crude extracts of Stevia rebaudiana Bertoni and Ajuga remota Benth grown in Ethiopia on alloxan-induced diabetic mice
CN115770209A (en) Rod-shaped lithospermum ointment containing three-purple oil and preparation method thereof
CN103565960B (en) A kind of semi-bionic extraction technology prepares the method for Semen Hoveniae extract (Fructus Hoveniae extract)
CN103829254A (en) Application of proanthocyanidins in preparing diet food or drug
CN103169764A (en) Pharmaceutical composition for treating eczema and preparation method thereof
CN107007500A (en) A kind of antiallergy rouge cream
CN106726987A (en) A kind of inhibiting bacteria and diminishing inflammation composition and its application
KR20110038551A (en) Cosmetic composition containing sophora angustifolia root, black cohosh, pueraria lobata root and punica granatum extract for anti-irritation effect and skin soothing effect
CN104523524B (en) Eye essence and preparation method prepared by composition are wanted based on one Plant Extracts
CN100484517C (en) Smash-resisting panax notoginseng total saponin free-dried powdery injection and its preparation

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20190101