CN109106799A - It is a kind of to contain conjugated linoleic acid, organic zinc, the myogenic cream of peptide components and preparation method thereof - Google Patents
It is a kind of to contain conjugated linoleic acid, organic zinc, the myogenic cream of peptide components and preparation method thereof Download PDFInfo
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Abstract
The present invention provide it is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream, wherein cla levels be 3.6-4.2%, peptide content 0.3-0.5%, n-hexane extract layer Zn2+Content is 1.5-1.9%；Also provide it is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream preparation method.The beneficial effects of the present invention are: make to generate conjugated linoleic acid, organic zinc, peptide components in myogenic cream finished product by carrying out different temperatures, the processing of time to raw material in order, peptide can effective acceleration of tissue repair, wound healing；Conjugated linoleic acid has the function of promotion cell division, somatomedin, anti-oxidant, the reaction of raising Cellular Immunity, reduction inflammatory reaction, can promote wound repair；Organic zinc has the advantages that biological value height, strengthen immunity, improves disease-resistant and oxidation resistance；For the myogenic cream for chronic wounds such as various trauma property skin defects, telephium, bedsore, diabetes, good effect is quick, easy to use, has no adverse reaction.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, contain conjugated linoleic acid, organic zinc, peptide components more particularly, to one kind
Myogenic cream and preparation method thereof.
Background technique
Refractory wound is primarily referred to as causing skin and soft tissue large defect or chronic wounds due to severe trauma, tool
Have that surface of a wound area is big, depth depth, chronic wounds Extracellular Matrix Remodeling, re-epithelialization are suppressed and long-time inflammatory reaction etc.
Feature belongs to frequently problem in surgery and Orthopeadic Surgery treatment.For surgical infections such as various skin diseases and burn and scalds
Caused refractory wound, carries out cleaning and externally applied drug is smeared, and the quality of externally applied drug determines the healing of wound.
The drug of existing clinical treatment surgical infection mainly includes antibiotic medicine and Chinese medicine.Take antibiotic to dosage and
The course for the treatment of there are certain requirements, and Time of Administration is unsuitable too long, and side effect is big.Myogenic cream is TCM surgery common medicine, comes from Zhang Shanlei
" ulcer section outline ", has effects that myogenic, sore, for treating wound concurrent infection, pressure ulcer, diabetes, veins of lower extremity
Chronic wound caused by ulcer, burn and scald etc. is significant in efficacy.The existing most complicated composition of myogenic cream, effective substance is indefinite,
Unstable quality, curative effect is not significant, and is only capable of being treated for certain a kind of or similar Cutaneous lesion of a few classes, therapeutic domain
It is relatively narrow.
Summary of the invention
The problem to be solved in the present invention is to provide it is a kind of containing conjugated linoleic acid, organic zinc, peptide components, can be used for it is various
Refractory wounds and myogenic cream and preparation method thereof significant in efficacy.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: one kind containing conjugated linoleic acid, organic zinc,
The myogenic cream of peptide components, cla levels are 3.6-4.2%, peptide content 0.3-0.5%, n-hexane in the myogenic cream
Extract layer Zn2+Content is 1.5-1.9%.
It is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream, made of the bulk pharmaceutical chemicals of following weight ratio:
10-15 parts more than green blood, 20-30 parts of raw tortoise plastron, 10-15 parts of Radix Angelicae Sinensis, 22-26 parts of Radix Rehmanniae, 27-33 parts of gypsum, calamine 28-32
Part, 15-20 parts of elephant hide, 80-100 parts of yellow wax, 450-550 parts of vegetable oil.
In technical solution, it is preferred that 12-14 parts more than green blood, 23-26 parts of raw tortoise plastron, 11-14 parts of Radix Angelicae Sinensis, Radix Rehmanniae 23-26
Part, 28-31 parts of gypsum, 30-32 parts of calamine, 16-18 parts of elephant hide, 85-95 parts of yellow wax, 480-520 parts of vegetable oil.
In technical solution, it is preferred that the vegetable oil is sesame oil.
It is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream preparation method, include the following steps:
S1. raw material is weighed by formula, 50% vegetable oil is taken to be heated to 230-270 DEG C, be put into more than green blood, frying 10-15 points
Clock is to atherosclerotic；
S2. remaining vegetable oil is added, is down to 180-220 DEG C to oil temperature, is put into raw tortoise plastron frying 18-23 minutes, until being in chestnut
Sub- color of the leather；
S3. Radix Rehmanniae is put into 180-220 DEG C of frying 3-6 minutes to being deep-fried；Radix Angelicae Sinensis frying 1-3 minutes is put into being deep-fried；
S4. be put into gypsum, calamine, 180-220 DEG C frying 1.5-2.5 hours, until being in dark brown；Another extracting container will be yellow
Wax dissolves completely, and yellow wax is put into vegetable oil by filtering to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
In technical solution, it is preferred that be filtered and remove slag at the end of S3 step.
In technical solution, it is preferred that in S1 step, by formula weigh after raw material elephant hide talcum powder is ironed, crush, mistake
80-120 mesh.
In technical solution, it is preferred that in S1 step, weigh by formula and crush gypsum, calamine after raw material, cross 80-
120 meshes.
In technical solution, it is preferred that in S4 step, yellow wax solution time is 12-16 minutes.
In technical solution, it is preferred that in S1-S3 step, green blood is remaining, raw tortoise plastron, Radix Rehmanniae, Radix Angelicae Sinensis are respectively after frying
It pulls out.
The advantages and positive effects of the present invention are: by carrying out different temperatures, the processing of time to raw material in order
Make to generate conjugated linoleic acid, organic zinc, peptide components in myogenic cream finished product, oil temperature is down to 100 DEG C or less and is put into elephant hide and constantly stirs
Mix, can retain the peptides active material in elephant hide, peptide can effective acceleration of tissue repair, wound healing；Contain in sesame oil
Linoleic acid a part is converted into conjugated linoleic acid during the preparation process, conjugated linoleic acid may participate in the adjusting of immune system, tool
Play the role of promoting cell division, somatomedin, anti-oxidant, the reaction of raising Cellular Immunity, reduction inflammatory reaction, can promote
Into wound repair；Contain inorganic zinc in calamine, be partially converted into organic zinc during the preparation process, zinc is RNA synzyme and DNA
The co-factor of synzyme is DNA synthesis, cell division and albumen synthesis essential component, and compared to inorganic zinc, organic zinc has
Steady chemical structure, strengthen immunity, improves the advantages of disease-resistant and oxidation resistance at biological value height；The myogenic cream has
Detoxificationization is rotten, nourishing the blood and yin, closing in myogenic and other effects, for various trauma property skin defects, telephium, bedsore, glycosuria
The chronic wounds such as foot disease, good effect is quick, easy to use, has no adverse reaction.
Specific embodiment
Test example
The assay of peptide in myogenic cream:
Seralbumin (ox) reference substance albumen quality concentration within the scope of 36.32~272.4 μ g/mL, absorbance (A) with
Mass concentration (C) is in good linear relationship.
Myogenic cream about 2.5g is taken, it is accurately weighed, it sets in stuffed conical flask, n-hexane 20ml is added, be ultrasonically treated (power
240W, frequency 40kHz) 5 minutes, filtration.Filter residue volatilizes n-hexane, and water 50ml is added in precision, and weighed weight is ultrasonically treated (function
Rate 240W, frequency 40kHz) 15 minutes, it lets cool, then weighed weight, the weight of less loss is supplied with water, is shaken up, filter, precision measures
In filtrate 2ml to test tube, add forint phenol test solution A 10mL, shake up, 37 DEG C of placement 10min rapidly join forint phenol test solution B
1mL shakes up immediately, and 30min is placed at 37 DEG C, and after colour developing, ice bath 5min takes supernatant appropriate, as test solution.It is accurate
It measures in water 1mL to test tube, adds forint phenol test solution A 5mL, shake up, 37 DEG C of placement 10min rapidly join forint phenol test solution B
0.5mL shakes up immediately, and 30min is placed at 37 DEG C, after colour developing, ice bath 5min, as placebo solution.Precision measures 140 μ
G/mL seralbumin (ox) reference substance solution 1mL is operated from " forint phenol test solution A 5mL " with method, molten as reference substance
Liquid.
According to UV-VIS spectrophotometry, test solution and reference substance solution are measured at wavelength 750nm or so place
Absorbance calculates the content of peptide in myogenic cream according to the reference substance comparison method in content assaying method.
The assay of myogenic cream n-hexane extract layer organic zinc:
Myogenic cream about 5g is taken, it is accurately weighed, it sets in stuffed conical flask, n-hexane 20ml is added in precision, and close plug is weighed heavy
Amount, ultrasonic treatment (power 240W, frequency 40kHz) 5 minutes, lets cool, then weighed weight, the weight of less loss is supplied with n-hexane,
It shaking up, stands, precision measures supernatant 10ml, it sets in stuffed conical flask, precision addition dilute hydrochloric acid 20ml, close plug, weighed weight,
It is ultrasonically treated (power 240W, frequency 40kHz) 5 minutes, lets cool, then weighed weight, the weight of less loss is supplied with dilute hydrochloric acid, is shaken
It is even, it stands, precision measures dilute hydrochloric acid layer 10ml, enriching ammonia solution and ammonia-ammonium chloride buffer (PH10.0) each 10ml, it shakes up,
Add disodium hydrogen phosphate test solution 10ml, shake up, the mixed liquor for adding 1 part of ammonia-ammonium chloride buffer (PH10.0) with 4 parts of water washs
30ml, 30% triethanolamine solution 15ml and chromium black T indicator are a small amount of, with Calcium Disodium Versenate titrating solution (0.05mol/
L) being titrated to solution becomes pure blue from aubergine.Every 1ml Calcium Disodium Versenate titrating solution (0.05mol/L) is equivalent to
3.269mg Zn2+。
The assay of conjugated linoleic acid in myogenic cream:
Within the scope of 3.62~39.82 μ g/mL, absorbance (A) is in conjugated linoleic acid reference substance concentration with mass concentration (C)
Good linear relationship.
Myogenic cream about 2.5mg is taken, it is accurately weighed, it sets in stuffed conical flask, precision addition dehydrated alcohol 5ml, weighed weight,
It is ultrasonically treated (power 240W, frequency 40kHz) 2 minutes, lets cool, then weighed weight, the weight of less loss is supplied with dehydrated alcohol, is shaken
Even, filtration takes filtrate, according to UV-VIS spectrophotometry, measures absorbance at 230~232nm of wavelength or so place.With 18 μ
G/mL conjugated linoleic acid reference substance solution is control, according to the reference substance in UV-VIS spectrophotometry content assaying method
Comparison method calculates the content of conjugated linoleic acid in myogenic cream.
Embodiment 1
Accurately weigh following raw material: green blood mores than 10 parts, and 23 parts of raw tortoise plastron, 11 parts of Radix Angelicae Sinensis, 25 parts of Radix Rehmanniae, 28 parts of gypsum,
33 parts of calamine, 18 parts of elephant hide, 80 parts of yellow wax, 480 parts of sesame oil.
S1. elephant hide talcum powder is ironed, beat powder, cross 80 meshes, gypsum, calamine crushed, 80 meshes are crossed；It takes
50% vegetable oil is heated to 230 DEG C, is put into more than green blood, frying 12 minutes to atherosclerotic, filter and remove residue；
S2. remaining vegetable oil is added, is down to 200 DEG C to oil temperature, is put into raw tortoise plastron frying 22 minutes, until be in chestnut color of the leather,
Filter and remove residue；
S3. be put into Radix Rehmanniae 200 DEG C frying 6 minutes to being deep-fried, pull out；Radix Angelicae Sinensis frying 3 minutes are put into being deep-fried, is filtered off
Slag；
S4. be put into gypsum, calamine, 190 DEG C frying 2 hours, until being in dark brown；Yellow wax is dissolved 13 points by another extracting container
Clock filters to dissolving completely, yellow wax is put into vegetable oil to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
Embodiment 2
Accurately weigh following raw material: green blood mores than 14 parts, and 20 parts of raw tortoise plastron, 15 parts of Radix Angelicae Sinensis, 24 parts of Radix Rehmanniae, 28 parts of gypsum,
28 parts of calamine, 16 parts of elephant hide, 95 parts of yellow wax, 550 parts of sesame oil.
S1. elephant hide talcum powder is ironed, beat powder, cross 120 meshes, gypsum, calamine crushed, 120 meshes are crossed；It takes
50% vegetable oil is heated to 260 DEG C, is put into more than green blood, frying 15 minutes to atherosclerotic, filter and remove residue；
S2. remaining vegetable oil is added, is down to 180 DEG C to oil temperature, is put into raw tortoise plastron frying 20 minutes, until be in chestnut color of the leather,
Filter and remove residue；
S3. be put into Radix Rehmanniae 210 DEG C frying 3 minutes to being deep-fried, pull out；Radix Angelicae Sinensis frying 1 minute is put into being deep-fried, is filtered off
Slag；
S4. be put into gypsum, calamine, 200 DEG C frying 2.5 hours, until being in dark brown；Yellow wax is dissolved 12 by another extracting container
Minute to dissolving completely, filters, yellow wax is put into vegetable oil to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
Embodiment 3
Accurately weigh following raw material: green blood mores than 12 parts, and 30 parts of raw tortoise plastron, 10 parts of Radix Angelicae Sinensis, 26 parts of Radix Rehmanniae, 31 parts of gypsum,
30 parts of calamine, 15 parts of elephant hide, 100 parts of yellow wax, 450 parts of sesame oil.
S1. elephant hide talcum powder is ironed, beat powder, sieve with 100 mesh sieve, by gypsum, calamine crush, sieve with 100 mesh sieve；It takes
50% vegetable oil is heated to 250 DEG C, is put into more than green blood, frying 13 minutes to atherosclerotic, filter and remove residue；
S2. remaining vegetable oil is added, is down to 190 DEG C to oil temperature, is put into raw tortoise plastron frying 18 minutes, until be in chestnut color of the leather,
Filter and remove residue；
S3. be put into Radix Rehmanniae 180 DEG C frying 4 minutes to being deep-fried, pull out；Radix Angelicae Sinensis frying 2 minutes are put into being deep-fried, is filtered off
Slag；
S4. be put into gypsum, calamine, 180 DEG C frying 2 hours, until being in dark brown；Yellow wax is dissolved 15 points by another extracting container
Clock filters to dissolving completely, yellow wax is put into vegetable oil to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
Embodiment 4
Accurately weigh following raw material: green blood mores than 15 parts, and 26 parts of raw tortoise plastron, 14 parts of Radix Angelicae Sinensis, 22 parts of Radix Rehmanniae, 27 parts of gypsum,
32 parts of calamine, 20 parts of elephant hide, 85 parts of yellow wax, 520 parts of sesame oil.
S1. elephant hide talcum powder is ironed, beat powder, sieve with 100 mesh sieve, by gypsum, calamine crush, sieve with 100 mesh sieve；It takes
50% vegetable oil is heated to 270 DEG C, is put into more than green blood, frying 10 minutes to atherosclerotic, filter and remove residue；
S2. remaining vegetable oil is added, is down to 220 DEG C to oil temperature, is put into raw tortoise plastron frying 23 minutes, until be in chestnut color of the leather,
Filter and remove residue；
S3. be put into Radix Rehmanniae 220 DEG C frying 5 minutes to being deep-fried, pull out；Radix Angelicae Sinensis frying 3 minutes are put into being deep-fried, is filtered off
Slag；
S4. be put into gypsum, calamine, 220 DEG C frying 1.5 hours, until being in dark brown；Yellow wax is dissolved 16 by another extracting container
Minute to dissolving completely, filters, yellow wax is put into vegetable oil to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
Assay, result such as table 1 are carried out to the myogenic cream finished product of embodiment 1-4.
Conjugated linoleic acid, peptide, n-hexane extract layer Zn in 1 embodiment 1-4 myogenic cream of table2+Assay result
After measured, detected in the myogenic cream of embodiment 1-4 manufacture the conjugated linoleic acid, peptides and zinc of certain content from
Son.
Use example
In order to verify clinical effectiveness of the invention, clinical verification is carried out to the myogenic cream in Tianjin Hospital, Tianjin City:
50 bed sore at ulcerative stage patients are chosen as research object, wherein male 29, female 21；Age is 21-76 years old, is put down
The equal age be (47.9 ± 6.3) year；Wherein pressure sore occurs have 31 in sacrum tail, and crista iliaca has 15, other positions have 4.With
Machine is divided into control group and observation group, and every group 25.Male 16, female 9 in observation group.
2 groups of patients are not significantly different (P > 0.05) in terms of the general information such as age, gender, pressure sore position, have
Comparativity.
Drug control group uses the dressing of ANER DIAN surgical debridement, and observation group is treated using myogenic cream.
Sore face nursing: firstly, 2 groups of patients aseptically carry out thoroughly sore face using hydrogen peroxide and physiological saline
Purulent secretion and necrotic tissue are removed in cleaning.It is carried out disinfection with ANER DIAN cotton balls to the skin around sore face, whole process is equal
Using full exposure method.On this basis, the patient of control group embrocates sore face with ANER DIAN disinfectant, embrocate daily number according to
Open sore part infection severity is determined, 1-4 times daily；The patient of observation group dips myogenic cream using sterile spatula and uniformly applies
It smears on sterile absorbent cotton, it is smooth to be affixed on sore face, with immobilization with adhesive tape, once a day.It also needs to place under repair to sore face when dressing,
The organization edge of necrosis is removed, muscle growth, wound healing are promoted.
Assisted care: 2 groups of patients give timing turning over, and every 2h is carried out 1 time, slept air bed, keep the drying of bed whole
It is clean.It is appropriate to give homovitamin, high heat, high protein and digestible food according to the state of an illness of patient, improve patient's
Nutrition condition.
Criterion of therapeutical effect: according to " Chinese disease Standardization of diagnosis and curative effect " evaluation criteria: cure: the surface of a wound heals completely, ulcer table
Face, which has been formed a scab, to fall off；Effective: the surface of a wound heals substantially, and purulent secretion almost disappears, the visible granulation tissue growth of the surface of a wound；Have
Effect: ulcer surface purulent secretion is reduced, and the surface of a wound has the tendency that healing；Invalid: the surface of a wound does not heal or more serious, the surface of a wound
Increase, purulent secretion constantly oozes out.
After whole Ointment Treatment, the state of an illness of 2 groups of patients is improved.From the point of view of wound healing time, control
Group is average to need (32 ± 5.5) d, and observation group averagely needs (15 ± 2.4) d, is considerably less than control group (P the time required to observation group
< 0.05).Compare in terms of clinical efficacy and is shown in Table 2.
22 groups of patient clinical curative effects of table compare n (%)
| Group | n | It cures | It is effective | Effectively | In vain | Total effective rate/% |
| Control group | 25 | 10(40.0) | 6(24.0) | 5(20.0) | 4(16.0) | 84.0 |
| Observation group | 25 | 18(72.0)* | 6(24.0) | 1(4.0) | 0 | 100* |
Note: compared with the control group, * P < 0.05
Several embodiments of the invention are described in detail above, but the content is only preferable implementation of the invention
Example, should not be considered as limiting the scope of the invention.It is all according to all the changes and improvements made by the present patent application range
Deng should still be within the scope of the patent of the present invention.
Claims (10)
1. it is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream, it is characterised in that: be conjugated in the myogenic cream sub-
Oleic acid content is 3.6-4.2%, peptide content 0.3-0.5%, n-hexane extract layer Zn2+Content is 1.5-1.9%.
2. it is a kind of containing conjugated linoleic acid, organic zinc, peptide components myogenic cream, which is characterized in that by the raw material of following weight ratio
Made of medicine: 10-15 parts more than green blood, 20-30 parts of raw tortoise plastron, 10-15 parts of Radix Angelicae Sinensis, 22-26 parts of Radix Rehmanniae, 27-33 parts of gypsum, furnace
Sweet stone 28-32 parts, 15-20 parts of elephant hide, 80-100 parts of yellow wax, 450-550 parts of vegetable oil.
3. myogenic cream according to claim 2, it is characterised in that: 12-14 parts more than green blood, 23-26 parts of raw tortoise plastron, Radix Angelicae Sinensis
11-14 parts, 23-26 parts of Radix Rehmanniae, 28-31 parts of gypsum, 30-32 parts of calamine, 16-18 parts of elephant hide, 85-95 parts of yellow wax, plant
It is 480-520 parts oily.
4. myogenic cream according to claim 2 or 3, it is characterised in that: the vegetable oil is sesame oil.
5. according to claim 1 described in -4 it is any containing conjugated linoleic acid, organic zinc, peptide components myogenic cream preparation
Method, which comprises the steps of:
S1. raw material is weighed by formula, 50% vegetable oil is taken to be heated to 230-270 DEG C, be put into more than green blood, frying 10-15 minutes；
S2. remaining vegetable oil is added, is down to 180-220 DEG C to oil temperature, is put into raw tortoise plastron frying 18-23 minutes；
S3. be put into Radix Rehmanniae 180-220 DEG C frying 3-6 minutes；It is put into Radix Angelicae Sinensis frying 1-3 minutes；
S4. be put into gypsum, calamine, 180-220 DEG C frying 1.5-2.5 hours, until being in dark brown；Another extracting container is complete by yellow wax
It dissolves entirely, filters, yellow wax is put into vegetable oil to the end of gypsum, calamine frying；
S5. oil temperature is down to 100 DEG C hereinafter, be put into elephant hide, is stirred continuously to being cooled to cream.
6. the preparation method of myogenic cream according to claim 5, it is characterised in that: be filtered at the end of S3 step
Slag.
7. the preparation method of myogenic cream according to claim 5, it is characterised in that: in S1 step, weigh raw material by formula
Afterwards that elephant hide talcum powder is ironed, crushing, crosses 80-120 mesh.
8. the preparation method of myogenic cream according to claim 5, it is characterised in that: in S1 step, weigh raw material by formula
Gypsum, calamine are crushed afterwards, cross 80-120 mesh.
9. the preparation method of myogenic cream according to claim 5, it is characterised in that: in S4 step, yellow wax solution time is
12-16 minutes.
10. the preparation method of myogenic cream according to claim 5, it is characterised in that: in S1-S3 step, green blood is remaining, raw tortoise
Plate, Radix Rehmanniae, Radix Angelicae Sinensis are pulled out after frying respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811071919.4A CN109106799A (en) | 2018-09-14 | 2018-09-14 | It is a kind of to contain conjugated linoleic acid, organic zinc, the myogenic cream of peptide components and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811071919.4A CN109106799A (en) | 2018-09-14 | 2018-09-14 | It is a kind of to contain conjugated linoleic acid, organic zinc, the myogenic cream of peptide components and preparation method thereof |
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| CN109106799A true CN109106799A (en) | 2019-01-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811071919.4A Pending CN109106799A (en) | 2018-09-14 | 2018-09-14 | It is a kind of to contain conjugated linoleic acid, organic zinc, the myogenic cream of peptide components and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113230409A (en) * | 2020-12-28 | 2021-08-10 | 上海奥茵特生物科技有限公司 | Traditional Chinese medicine composite matrix ointment for promoting wound healing |
-
2018
- 2018-09-14 CN CN201811071919.4A patent/CN109106799A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 刘彦生等: "生肌象皮膏的制备及临床应用", 《辽宁药物与临床》 * |
| 李茜等: "生肌象皮膏制备工艺的改进", 《中医外治杂志》 * |
| 穆万荣等: "生肌象皮膏的制备与临床应用观察", 《贵阳医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113230409A (en) * | 2020-12-28 | 2021-08-10 | 上海奥茵特生物科技有限公司 | Traditional Chinese medicine composite matrix ointment for promoting wound healing |
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Application publication date: 20190101 |