CN108392572A - A kind of plaster and its preparation method and application that expelling the stasis for the new sore relieves the pain - Google Patents
A kind of plaster and its preparation method and application that expelling the stasis for the new sore relieves the pain Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/28—Mercury; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention discloses a kind of plaster that expelling the stasis for the new sore relieves the pain, it comprising Chinese medicine material make a living it is white hold back 20 ~ 40 parts, 20 ~ 40 parts of the raw bletilla striata, 40 ~ 80 parts of calcined gypsum, 30 ~ 60 parts of calcined Dragon's bone, 30 ~ 60 parts of pearl, 10 ~ 20 parts of dragon's blood, 10 ~ 20 parts of cinnabar.The present invention is according to traditional Chinese medical theory, Chinese medicinal composition is screened by many experiments, to hold back 20g in vain, bletilla striata 20g, calcined gypsum 40g, calcined Dragon's bone 30g and pearl 30g are that Chinese medicinal component is the first component and is the second component with dragon's blood and each 10g of cinnabar superfine powder, the experimental results showed that, plaster provided by the invention has expelling the stasis for the new, hygroscopic sore and relieves the pain and other effects simultaneously, festers mouth to diabetes, skin infection etc. has promotes healing and other effects well.The preparation method of plaster provided by the invention, process stabilizing, reliable, production cost is low, and operability is strong, is suitble to industrialized production.
Description
Technical field
The present invention relates to a kind of drugs, and in particular to a kind of plaster that expelling the stasis for the new sore relieves the pain and preparation method thereof and answers
With.
Background technology
With aging of population, the elderly's metabolism is slow, and wound-healing abilities are poor, especially for diabetes
Crowd, wound are difficult to heal, and bring great pain to patient, chemicals generally use antalgica and antiphlogistic, effect
It is bad, and adverse reaction is larger.Lack currently on the market while there is expelling the stasis for the new, hygroscopic sore, the safe traditional Chinese medicinal ointment to relieve the pain
Medicine.
Therefore, it is necessary to which to research and develop a kind of compatibility on the basis of the prior art reasonable, while there is expelling the stasis for the new, receive
Wet sore, the safe traditional Chinese medicine plaster to relieve the pain.
Invention content
Goal of the invention：Present invention aim to address the deficiencies in the prior art, researched and developed on the basis of the prior art a kind of
Compatibility is reasonable, while having expelling the stasis for the new, hygroscopic sore, the safe traditional Chinese medicine plaster to relieve the pain.Another object of the present invention is to provide
The preparation method and applications of the traditional Chinese medicine plaster.
Technical solution：In order to achieve the goal above, the technical solution that the present invention takes is：
A kind of plaster that expelling the stasis for the new sore relieves the pain, it includes the raw material of following parts by weight：
It is raw to hold back 20~40 parts in vain, 20~40 parts of the raw bletilla striata, 40~80 parts of calcined gypsum, 30~60 parts of calcined Dragon's bone, pearl 30~
60 parts, 10~20 parts of dragon's blood, 10~20 parts of cinnabar.
Preferably, the plaster that above-described expelling the stasis for the new sore relieves the pain, it by following parts by weight raw material
It is made：
It is raw to hold back 20 parts in vain, 20 parts of the raw bletilla striata, 40 parts of calcined gypsum, 30 parts of calcined Dragon's bone, 30 parts of pearl, 10 parts of dragon's blood, cinnabar 10
Part.
Preferably, the preparation method for the plaster that above-described expelling the stasis for the new sore relieves the pain, includes the following steps：
(1) constant temperature water tank is adjusted to 50~80 degrees Celsius, water is added, beaker is placed in constant temperature water tank；
(2) vaseline is taken to be put into beaker thawing；
(3) it will hold back in vain, the bletilla striata, calcined gypsum, calcined Dragon's bone and pearl are mixed into superfine powder, pour into the burning equipped with vaseline
In cup, after stirring evenly；
(4) when temperature drops to 35 DEG C, dragon's blood and cinnabar superfine powder is added, stir evenly to get.
As more preferred scheme, the preparation method for the plaster that above-described expelling the stasis for the new sore relieves the pain, including with
Lower step：
(1) constant temperature water tank is adjusted to 50 degrees Celsius, 1000mL water is added, beaker is placed in constant temperature water tank；
(2) 500 grams of vaseline is taken to be put into beaker thawing；
(3) 20g, bletilla striata 20g, calcined gypsum 40g, calcined Dragon's bone 30g and pearl 30g will be held back in vain, are mixed into superfine powder, are poured into
In beaker equipped with vaseline, after stirring evenly；
(4) when temperature drops to 35 DEG C, dragon's blood and each 10g of cinnabar superfine powder is added, stir evenly to get.
The plaster that expelling the stasis for the new sore of the present invention relieves the pain is preparing expelling the stasis for the new, plaster that hygroscopic sore relieves the pain
Using.
Plaster provided by the invention have remove necrosis and promote granulation, hygroscopic sore, analgesic efficacy.It can be used for gangrene, the cold of bedsore coagulates
Blood stasis, blockage of the vessel card.It is equivalent to the wounds such as 3 grades of clinical medical diabetes or more, pressure sore difficult healing state long.
In plaster of the present invention, dragon's blood：The key medicine of scattered blood stasis, raw new blood, main broken hematocele, relieves pain raw meat.Experiment shows its water
It decocts alcohol precipitation liquid energy and obviously inhibits platelet aggregation, prevent thrombosis.Aqueous extracts are to staphylococcus aureus, staphylococcus albus
And a variety of pathomycetes have different degrees of inhibiting effect, so having facilitation to the healing of diabetic foot ulcer surface, prevent
Foot blood vessel blockage, tissue necrosis；And its fungistatic effect contributes to ulcer to restore.
Radix ampelopsis：Carbuncle swells subcutaneous ulcer sore, eliminating stagnation to stop pain, for the swollen ulcer man key medicine of malignant boil.Radix ampelopsis has very strong bacteriostasis, and has very strong
Anti-mycotic efficiency.The infection of fungi can effectively be inhibited at diabetic foot ulcer.
Pearl：It is clearing heat and detoxicating, remove necrosis and promote granulation.Pearl, which is applied with, can promote wound granulation hyperplasia.Pearl can eliminate diabetes
While foot leads to inflammation, slough is removed, new skin is promoted to grow.
The bletilla striata：Astringing to arrest bleeding, detumescence and promoting granulation.Local external use's haemostatic effect is preferable, can promote the solidifying of bleeding surface of a wound blood platelet
It is poly-, increase the quantity of phagocyte, it is inhibited to bleedings such as blood vessels；To hay bacillus, Candida albicans, Gold production Portugal
Grape coccus has inhibiting effect.The stagnant qi and blood of the stasis of blood is dredged by drug, to promote body to bear new skin, for diabetes
Treatment has important role.
Frankincense：Promoting blood circulation analgesic therapy, detumescence and promoting granulation.Frankincense can improve metabolism, to play anti-infectious function.Help to alleviate
The feeling of pain of patient with diabetic feet promotes the healing of ulcer wound surface.
Myrrh：Chinese medicine thinks have the effect of detumescence and promoting granulation, scattered stasis pain that can stimulate white blood cell, activated immune system；Its energy
Directly against microorganism, make sick body quick recovery, makes diabetic foot ulcer newly at faster metabolism, wound healing.
Pharmacological research shows：The traditional Chinese medicine ingredients in plaster that the present invention is prepared are to staphylococcus aureus, most of
Gram-positive bacteria, certain Gram-negative bacterias and common pathogenic fungus bacillus anthracis etc. have inhibiting effect, and not
It is also easy to produce drug resistance.In addition, the plaster of the present invention also has the function of adsorbing secretion and hemostasia effect, and energy hygroscopic analgesic,
Conducive to the protection surface of a wound, make its quick healing.Control blood glucose, it is anti-infectious on the basis of be used in combination outside plaster of the present invention
With, remove necrosis and promote granulation, hygroscopic sore, relieving pain, can reduce operation amputation risk, improve patient with diabetic feet live matter
Amount.
Advantageous effect：Compared to the prior art the plaster that expelling the stasis for the new sore provided by the invention relieves the pain has following excellent
Point:
1, the present invention screens Chinese medicinal composition, to hold back 20g in vain, bletilla striata 20g is forged according to traditional Chinese medical theory by many experiments
Gypsum 40g, calcined Dragon's bone 30g and pearl 30g are that Chinese medicinal component is the first component and is second with dragon's blood and each 10g of cinnabar superfine powder
Component, the experimental results showed that, the multiple efficacies such as plaster provided by the invention has expelling the stasis for the new, hygroscopic sore and relieves the pain simultaneously,
It festers mouth to diabetes, skin infection etc. has promotes healing and other effects well.The present invention is as external preparation, safety
It is good.
2, the preparation method of plaster provided by the invention, it is process stabilizing, reliable, easily implement, production cost is low, operability
By force, it is suitble to industrialized production.
3, the present invention is externally-applied soft ointment, is had the following advantages that：
1. fine and smooth uniform, no harsh feeling；2. viscosity is suitable, it is easy to be coated with；3. quality is relatively stablized；4. water imbibition compares
It is good,
The release of contained drug, penetration capacity are stronger；5. without bad irritation, anaphylaxis, adverse reaction is small.
Specific implementation mode
With reference to specific embodiment, the present invention is furture elucidated, it should be understood that these embodiments be merely to illustrate the present invention and
It is not used in and limits the scope of the invention, after having read the present invention, various of equal value shapes of the those skilled in the art to the present invention
The modification of formula falls within the application range as defined in the appended claims.
Embodiment 1
1, a kind of plaster that expelling the stasis for the new sore relieves the pain, it is made of the raw material of following parts by weight：
It is white to hold back 20 parts, 20 parts of the bletilla striata, 40 parts of calcined gypsum, 30 parts of calcined Dragon's bone, 30 parts of pearl, 10 parts of dragon's blood, 10 parts of cinnabar.
2, the preparation method for the plaster that expelling the stasis for the new sore provided by the invention relieves the pain, includes the following steps：
(1) constant temperature water tank is adjusted to 50 degrees Celsius, 1000mL water is added, beaker is placed in constant temperature water tank；
(2) 500 grams of vaseline is taken to be put into beaker thawing；
(3) 20g, bletilla striata 20g, calcined gypsum 40g, calcined Dragon's bone 30g and pearl 30g will be held back in vain, are mixed into superfine powder, are poured into
In beaker equipped with vaseline, after stirring evenly；
(4) when temperature drops to 35 DEG C, dragon's blood and each 10g of cinnabar superfine powder is added, stir evenly to get.
Embodiment 2
1, a kind of plaster that expelling the stasis for the new sore relieves the pain, it is made of the raw material of following parts by weight：
It is white to hold back 40 parts, 40 parts of the bletilla striata, 80 parts of calcined gypsum, 60 parts of calcined Dragon's bone, 60 parts of pearl, 20 parts of dragon's blood, 20 parts of cinnabar.
2, the preparation method for the plaster that expelling the stasis for the new sore provided by the invention relieves the pain, includes the following steps：
(1) constant temperature water tank is adjusted to 50 degrees Celsius, 2000mL water is added, beaker is placed in constant temperature water tank；
(2) 1000 grams of vaseline is taken to be put into beaker thawing；
(3) 40 parts will white be held back, 40 parts of the bletilla striata, 80 parts of calcined gypsum, 60 parts of 60 parts of calcined Dragon's bone and pearl are mixed into ultra-fine
Powder pours into the beaker equipped with vaseline, after stirring evenly；
(4) when temperature drops to 35 DEG C, dragon's blood and each 20g of cinnabar superfine powder is added, stir evenly to get.
3 lanqin oral solutions of embodiment
1 materials and methods
1.1 research object
60 patient with diabetic feet are chosen, the Yixing City hospital of traditional Chinese hospital is come from, meets WHO diabetes diagnostic criterions, wherein
Man 30, female 30 are diabetes B, and 51~75 years old age, 61 years old average, the course of disease 5~12 years is 7 years average, before being admitted to hospital
It is all made of oral hypoglycemic agents treatment, 11.32 ± 1.56mmol/L of fasting blood-glucose when being admitted to hospital is single lower limb ulcer, ulcer surface
146.3 ± 3.14cm of product2,It is not cured throughout the year.
1.2 research method
60 patients are randomly divided into two groups for the treatment of group, control group, wherein (prepared by the embodiment of the present invention 1 for treatment group 40
Obtained plaster), man 20, female 20；Control group 20, wherein man 10, female 10, each group clinic basic document has can
Compare property.
Two groups of patients give diabetic diet, and insulin controls blood glucose in ideal range.This hair for the treatment of group patient external application
The plaster treatment that bright embodiment 1 is prepared, 4 weeks are 1 course for the treatment of；Control group patient's external application bFGF-ESSEX (external application recombinant bovine alkalinity at
Fibroblast growth factor) treatment, 2 weeks are 1 course for the treatment of.
1.3 curative effect determinate standard
It is effective：80% or more Wound healing, granulation or epithelial tissue well-grown；Effectively：40% or more Wound healing, wound
Flushing profit, no oozing of blood have granulation tissue growth；In vain：Before and after treatment without improvement.
1.4 statistical method
Descriptive statistic：Enumeration data indicates that measurement data is used using composition ratio or rateIt indicates；Statistical inference：
Statistical method has parametric test and non-parametric test, and specific method has Chi-square Test, paired t-test and the t of sample is examined in groups
SPSS13.0 is used Deng, statistical software.
2 results
It is shown by the test result of table 1, the total effective rate of traditional Chinese medicine plaster provided by the invention and bFGF-ESSEX is respectively 85%
With 45%, as a result show that traditional Chinese medicine plaster curative effect provided by the invention is better than bFGF-ESSEX, and significant difference, statistically significant (p ＜
0.01)
1 two groups of Clinical efficacy comparisons of table
Diabetes be cause diabetic to be disabled, lethal severe chronic complication, can cause infection and amputation.It
There are the sings and symptoms of local infection, ulcer, gangrene or the surgical disease of necrosis, therefore the processing of local wound in the treatment must not
It can lack.Plaster provided by the invention has the promoting healing effect of good treatment diabetic ulcer, and without obvious adverse reaction.
And the present invention is held back by using the white of other weight ratio, the bletilla striata, calcined gypsum, calcined Dragon's bone, pearl, dragon's blood and Zhu
Sand carries out contrast experiment, finds other weight ratio (including scheme one：20 parts are held back in vain, 20 parts of the bletilla striata, 20 parts of calcined gypsum forges dragon
20 parts of bone, 20 parts of pearl, 10 parts of dragon's blood, 10 parts of cinnabar；Scheme two：It is white to hold back 10 parts, 10 parts of the bletilla striata, 20 parts of calcined gypsum, calcined Dragon's bone
20 parts, 20 parts of pearl, 5 parts of dragon's blood, 5 parts of cinnabar；Scheme three：It is white to hold back 40 parts, 40 parts of the bletilla striata, 10 parts of calcined gypsum, 10 parts of calcined Dragon's bone,
10 parts of pearl, 15 parts of dragon's blood, 15 parts of cinnabar；) Chinese medicine with plaster made of 1 method of embodiment diabetes B is merged
Infection, ulcer, gangrene or downright bad promoting healing effect are poor, and effective percentage is less than 50%.
4 animal effectiveness study of embodiment
1, experimental animal：Cleaning grade Kunming mouse 100 is male, 35~40g.
2, modeling：Mouse is normally fed after a week, 12 hours on an empty stomach, gives the abdominal cavities streptozotocin (STZ) 80mg/kg note
It penetrates.Blood examination is taken to survey blood glucose, blood glucose level after 72 hours again>16.7mmol/L can reach modeling standard.Reach the small of modeling standard
After mouse anesthesia, to mouse hind leg shaving, disinfection, the full thickness skin that about 1.5cm × 0.5cm is prepared with surgical method festers model.
3, experiment packet：60 diabetes exanthemv mouse by table of random number be divided into embodiment 1 plaster group and
Blank lotion control group, every group 30；Every time wound healing situation is recorded before medicine-feeding.Experimental animal sub-cage rearing, per one, cage,
It prevents collective raising from mutually licking and licks the surface of a wound, influence experiment result accuracy；It is protected in surface of a wound plastic film small with one, frivolous,
It prevents from mouse itself from licking to lick, influences experimental result.
4, medication：
Experimental group：The plaster group 2g for giving embodiment 1 after daily partly sterilised at the surface of a wound is uniformly applied to ulcer surface.
Control group：The surface of a wound gives blank lotion 2g and is uniformly applied to ulcer surface after daily partly sterilised.
5, observation index：Wound healing rate
Surface of a wound form and dimension is drawn with clear panel thin paper respectively after modeling and (by record number of days) at the end of observation, is used
Photograph is imported computer ImageJ softwares and calculates surface of a wound area, calculated healing rate, shrink by the pattern photograph that camera is drawn
Rate=(original area-wound institute area coverage) original area × 100% of/surface of a wound).
6, experimental result
2 two groups of Clinical efficacy comparisons of table
5 irritant experiment of embodiment
1, experimental animal：Health is provided without skin disease New Zealand White Rabbit 3, regular grade, Nanjing warren, quality certification number：SCXK
(Soviet Union) No. 2012-0003 number, weight 2.6-2.7kg.Experimental animal sub-cage rearing, per one, cage.
2, experimental method
Backbone both sides cropping preserved skin 3cm × 3cm, next day apply before by 1 plaster group of the embodiment of the present invention for 24 hours before rabbit experiment,
On 2.5cm × 2.5cm skin of unhairing, exposed skin is cleaned with 75% alcohol, is drawn in preserved skin area with sterilizing three-edged needle later
One " well " shape damage zone, skin damage only up to epidermis.
1 plaster 5g of the embodiment of the present invention is applied to (for maximum dosage-feeding) in the damage zone, two layers of gauze, one layer of oilpaper cover
Lid, with non-stimulated immobilization with adhesive tape, the other side applies the control of 5g blank lotions, is washed away with sterile saline after application 4h and remains Yu Ze
Cream observes and records dermoreaction after 1/24/48h.
3, experimental result
The plaster that the present invention is prepared applies with after skin surface, does not occur the irritative responses such as erythema, allergy, show
Mildly without obvious irritation.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (5)
1. a kind of plaster that expelling the stasis for the new sore relieves the pain, which is characterized in that it includes the raw material of following parts by weight：
It is raw to hold back 20 ~ 40 parts in vain, 20 ~ 40 parts of the raw bletilla striata, 40 ~ 80 parts of calcined gypsum, 30 ~ 60 parts of calcined Dragon's bone, 30 ~ 60 parts of pearl, dragon's blood
10 ~ 20 parts, 10 ~ 20 parts of cinnabar.
2. the plaster that expelling the stasis for the new sore according to claim 1 relieves the pain, which is characterized in that it is by following parts by weight
Raw material is made：
It is raw to hold back 20 parts in vain, 20 parts of the raw bletilla striata, 40 parts of calcined gypsum, 30 parts of calcined Dragon's bone, 30 parts of pearl, 10 parts of dragon's blood, 10 parts of cinnabar.
3. the preparation method for the plaster that expelling the stasis for the new sore as claimed in claim 1 or 2 relieves the pain, which is characterized in that including following
Step：
（1）Constant temperature water tank is adjusted to 50 ~ 80 degrees Celsius, water is added, beaker is placed in constant temperature water tank；（2）Vaseline is taken to be put into
Beaker melts；
（3）It holding back in vain, the bletilla striata, calcined gypsum, calcined Dragon's bone and pearl are mixed into superfine powder, pour into the beaker equipped with vaseline,
After stirring evenly；
（4）When temperature drops to 35 DEG C, dragon's blood and cinnabar superfine powder is added, stir evenly to get.
4. the preparation method for the plaster that expelling the stasis for the new sore according to claim 3 relieves the pain, which is characterized in that including following
Step：
（1）Constant temperature water tank is adjusted to 50 degrees Celsius, 1000mL water is added, beaker is placed in constant temperature water tank；（2）Take vaseline
500 grams are put into beaker thawing；
（3）20g, bletilla striata 20g, calcined gypsum 40g, calcined Dragon's bone 30g and pearl 30g will be held back in vain, are mixed into superfine powder, are poured into and be equipped with
In the beaker of vaseline, after stirring evenly；
（4）When temperature drops to 35 DEG C, dragon's blood and each 10g of cinnabar superfine powder is added, stir evenly to get.
5. the plaster that expelling the stasis for the new sore as claimed in claim 1 or 2 relieves the pain is in the cream for preparing expelling the stasis for the new, hygroscopic sore relieves the pain
The application of medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810351783.6A CN108392572B (en) | 2018-04-19 | 2018-04-19 | Plaster for removing stasis, promoting tissue regeneration, healing sore and relieving pain and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810351783.6A CN108392572B (en) | 2018-04-19 | 2018-04-19 | Plaster for removing stasis, promoting tissue regeneration, healing sore and relieving pain and preparation method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN108392572A true CN108392572A (en) | 2018-08-14 |
| CN108392572B CN108392572B (en) | 2021-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810351783.6A Active CN108392572B (en) | 2018-04-19 | 2018-04-19 | Plaster for removing stasis, promoting tissue regeneration, healing sore and relieving pain and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904660A (en) * | 2018-08-31 | 2018-11-30 | 徐高阳 | A kind of liniment for treating bedsore and diabetes |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166973A (en) * | 1996-05-30 | 1997-12-10 | 刘全有 | Multi-function ointment for burn and scald |
| CN101607014B (en) * | 2008-06-18 | 2011-11-23 | 朱春燕 | Ointment for promoting tissue regeneration and restraining sore and preparation method thereof |
-
2018
- 2018-04-19 CN CN201810351783.6A patent/CN108392572B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166973A (en) * | 1996-05-30 | 1997-12-10 | 刘全有 | Multi-function ointment for burn and scald |
| CN101607014B (en) * | 2008-06-18 | 2011-11-23 | 朱春燕 | Ointment for promoting tissue regeneration and restraining sore and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘剑: "生肌收口粉治疗外科慢性溃疡", 《中医外治杂志》 * |
| 林修森等: "化疽生新膏促进糖尿病大鼠溃疡创面愈合的实验研究", 《湖北中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904660A (en) * | 2018-08-31 | 2018-11-30 | 徐高阳 | A kind of liniment for treating bedsore and diabetes |
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| CN108392572B (en) | 2021-03-23 |
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