CN109078163A - A kind of Chinese medicine for treating knot card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach - Google Patents
A kind of Chinese medicine for treating knot card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach Download PDFInfo
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Abstract
The present invention relates to the Chinese medicines that card is tied in the treatment weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach, it can effectively solve the problems, such as the medication of knot card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach, its solve technical solution be, the Chinese medicine is made of the material medicine of following poidometer: Radix Codonopsis 10-20g, Rhizoma Atractylodis Macrocephalae 10-20g, curcuma zedoary 8-17g, ginger 3-9g, coptis 2-4g, tuber of pinellia 8-17g, endothelium corneum gigeriae galli 10-20g, coloured malt 10-20g, rhizoma cyperi 8-17g, rhizoma corydalis 8-17g, sword bean 8-17g and Chinese actinidia root 6-14g, compatibility of the present invention is scientific and reasonable, abundant raw material, it is convenient to take, effect is good, strengthening the spleen and stomach is played altogether, it is pungent to open bitter drop, the benefits of dissolving blood stasis and detoxication, the transfer and metastatic lesion that primary lesion can be effectively controlled continue to spread, effective for treating gastric cancer Knot card patient in the weak cold-heat jumble extravasated blood of spleen deficiency stomach, is the innovation treated in gastric cancer medicament.
Description
Technical field
The present invention relates to field of medicaments, especially a kind of to treat in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach in knot card
Medicine.
Background technique
Gastric cancer is digestive system kinds of tumor, and as middle and advanced stage when often finding has 80% or more patients with gastric cancer, all can
There is upper abdomen pain, uncomfortable phenomenon, there is 1/3 gastric cancer to have the performance of appetite stimulator, either which kind of tumour, in cancer cell
In growth course, a large amount of nutriment and energy are needed, also therefore will lead to other body normal tissues can not obtain nutrition,
To show as apparent syntexis.Most of patient will appear nausea, vomiting, sour regurgitation.With the growth of tumour, can destroy in stomach
Thin vessels, therefore have the Symptoms of fecal occult blood, but if the blood vessel invaded is larger, then can up cause spitting blood, it is past
Under then will appear melena, progression of disease is fast, and patients ' life quality is very poor, though chemicotherapy can delay progression of disease to a certain extent,
But adverse reaction aggravates, and traditional Chinese medicine can be relieved patient symptom by integrated regulation and diagnosis and treatment, improve the quality of living, and enhancing is exempted from
Epidemic disease power and extension life cycle.Therefore, the improvement in Chinese medicine treatment gastric cancer medicament and innovation are imperative.
Summary of the invention
For above situation, for the defect for solving the prior art, the purpose of the present invention, which is just to provide, a kind of treats gastric cancer spleen
The Chinese medicine of knot card in the empty weak cold-heat jumble extravasated blood of stomach, can effectively solve the medication of knot card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach
Problem.
The technical solution that the present invention solves is that the Chinese medicine is made of the material medicine of following poidometer: Radix Codonopsis 10-20g,
Rhizoma Atractylodis Macrocephalae 10-20g, curcuma zedoary 8-17g, ginger 3-9g, coptis 2-4g, tuber of pinellia 8-17g, endothelium corneum gigeriae galli 10-20g, coloured malt 10-20g, perfume (or spice)
Attached 8-17g, rhizoma corydalis 8-17g, sword bean 8-17g and Chinese actinidia root 6-14g, wherein crush Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, rhizoma corydalis simultaneously
Add the ethanol percolation that Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured are 70%, at 45-55 DEG C, be concentrated under reduced pressure
Be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4 taste medicinal material of rhizoma corydalis the dregs of a decoction and Radix Codonopsis, Huang
Company, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli merge, and add 4-6 times of the material medicine water measured
It decocts 2 times, it is 1-2 hours each, merge 2 gained decocting liquids, at 45-55 DEG C, the leaching that preparation relative density is 1.2 is concentrated under reduced pressure
Cream merges 2 medicinal extract being prepared, and is dried, crushed into medicinal powder, and auxiliary material is added, and medicinal powder and ratio of adjuvant are 1:2, auxiliary material group
It is 80% ethyl alcohol as wetting agent using mass concentration as dextrin-Icing Sugar 1:1, softwood is uniformly made, crosses the granulation of 20 meshes, 55-65
DEG C be dried, the granulation of 14 mesh sieves, packing to get.
Compatibility of the present invention is scientific and reasonable, and abundant raw material is convenient to take, and effect is good, plays strengthening the spleen and stomach altogether, pungent to open bitter drop, changes
The benefits of stasis of blood is detoxified, the transfer and metastatic lesion that primary lesion can be effectively controlled continue to spread, effective for treating gastric cancer spleen deficiency
Knot card patient in the weak cold-heat jumble extravasated blood of stomach, is the innovation treated in gastric cancer medicament.
Specific embodiment
Specific embodiments of the present invention will be described in further detail with reference to embodiments.
Embodiment 1
The present invention in the specific implementation, can be made of the material medicine of following poidometer: Radix Codonopsis 11g, Rhizoma Atractylodis Macrocephalae 19g, curcuma zedoary 9g, life
Ginger 8g, coptis 2g, tuber of pinellia 16g, endothelium corneum gigeriae galli 11g, coloured malt 19g, rhizoma cyperi 9g, rhizoma corydalis 16g, sword bean 9g and Chinese actinidia root 13g,
In, crushing and add Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured for Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, rhizoma corydalis is 70%
Ethanol percolation, at 45 DEG C, be concentrated under reduced pressure be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, prolong
The dregs of a decoction of 4 taste medicinal material of Hu rope merge with Radix Codonopsis, the coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli
Together, add the water of 4 times of material medicine amounts to decoct 2 times, 1 hour every time, merge 2 gained decocting liquids and system is concentrated under reduced pressure at 45 DEG C
The medicinal extract that standby relative density is 1.2 merges 2 medicinal extract being prepared, and is dried, crushed into medicinal powder, is added auxiliary material, medicinal powder with it is auxiliary
Material proportion is 1:2, and auxiliary material group becomes dextrin-Icing Sugar 1:1, is 80% ethyl alcohol as wetting agent using mass concentration, softwood is uniformly made,
Cross 20 meshes granulation, 55 DEG C are dried, 14 mesh sieves granulation, packing to get.
Embodiment 2
The present invention in the specific implementation, can also be made of the material medicine of following poidometer: Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, curcuma zedoary
12g, ginger 6g, coptis 3g, tuber of pinellia 12g, endothelium corneum gigeriae galli 15g, coloured malt 15g, rhizoma cyperi 12g, rhizoma corydalis 12g, sword bean 12g and Chinese gooseberry
Root 10g, wherein crush and add Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, the quality of 5 times of rhizoma corydalis amounts dense Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, rhizoma corydalis
Degree be 70% ethanol percolation, at 50 DEG C, be concentrated under reduced pressure be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia,
Sword bean, the dregs of a decoction of 4 taste medicinal material of rhizoma corydalis and Radix Codonopsis, the coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicine of endothelium corneum gigeriae galli
Material merges, and adds the water of 5 times of material medicine amounts to decoct 2 times, 1.5 hours every time, merges 2 gained decocting liquids, at 50 DEG C,
The medicinal extract that preparation relative density is 1.2 is concentrated under reduced pressure, merges 2 medicinal extract being prepared, is dried, crushed into medicinal powder, is added auxiliary
Material, medicinal powder and ratio of adjuvant are 1:2, and it is 80% ethyl alcohol as wetting agent using mass concentration, that auxiliary material group, which becomes dextrin-Icing Sugar 1:1,
It is even to be made softwood, cross the granulation of 20 meshes, 60 DEG C are dried, the granulation of 14 mesh sieves, packing to get.
Embodiment 3
The present invention in the specific implementation, can also be made of the material medicine of following poidometer: Radix Codonopsis 19g, Rhizoma Atractylodis Macrocephalae 11g, curcuma zedoary
16g, ginger 4g, coptis 4g, tuber of pinellia 9g, endothelium corneum gigeriae galli 19g, coloured malt 11g, rhizoma cyperi 16g, rhizoma corydalis 9g, sword bean 16g and Chinese actinidia root
7g, wherein Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, rhizoma corydalis are crushed and added Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured
It is concentrated under reduced pressure at 45-55 DEG C for 70% ethanol percolation and is prepared into the medicinal extract that relative density is 1.2, by above-mentioned Rhizoma Atractylodis Macrocephalae, half
Summer, sword bean, the dregs of a decoction of 4 taste medicinal material of rhizoma corydalis and Radix Codonopsis, the coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste of endothelium corneum gigeriae galli
Medicinal material merges, and adds 4-6 times of the material medicine water measured to decoct 2 times, 2 hours every time, merges 2 gained decocting liquids, in 45-55
At DEG C, the medicinal extract that preparation relative density is 1.2 is concentrated under reduced pressure, merges 2 medicinal extract being prepared, is dried, crushed into medicinal powder, adds
Enter auxiliary material, medicinal powder and ratio of adjuvant are 1:2, and it is 80% ethyl alcohol as wetting using mass concentration that auxiliary material group, which becomes dextrin-Icing Sugar 1:1,
Agent, is uniformly made softwood, crosses the granulation of 20 meshes, and 65 DEG C are dried, the granulation of 14 mesh sieves, packing to get.
Chinese medicine thinks that The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, the pivot of ascending or descending movement of vital Qi, occupies in the vital movement of human body
Critically important status." Treatise on the spleen and stomach taste actual situation progress of disease opinion " cloud " both hurt, and vigour cannot also fill, and the institute of all diseases by QI of the spleen and stomach
By giving birth to ", it is believed that the generation of disease is all because taste are impaired.Modern scholar think more the generation of gastric cancer with " void, phlegm, the stasis of blood,
Poison " is closely related.The present invention is pungent to open hardship with strengthening the spleen and stomach for the interpretation of the cause, onset and process of an illness feature tied in the weak cold-heat jumble extravasated blood of its spleen deficiency stomach
Drop, dissolving blood stasis and detoxication is the rules for the treatment of.Radix Codonopsis is sweet in flavor mild-natured in side, tonifying middle-Jiao and Qi, strengthening spleen and nourishing stomach；Rhizoma Atractylodis Macrocephalae bitter but sweet flavor and it is warm-natured, invigorating the spleen is dry
It is wet, eliminate dampness and have diuretic effect；Two medicines share, and mutual reinforcement between matches, and not only gain gas helped the power of fortune, but also the benefits of strong strengthening the spleen and stomach, was altogether monarch drug in a prescription.The tuber of pinellia
Pungent-warm, dissipating bind is except full, stopping nausea and vomiting by lowering the adverse flow of QI；Coptis bitter cold, clearing heat-fire, eliminating dampness open ruffian；Two medicine compatibilities, simultaneously using both cold and hot drugs with and yin-yang,
It works hard and to increase drop；Rhizoma cyperi, pungent row hardship are let out, are relieved pain in qi-regulating tune；Compatibility ginger again, not only warming middle energizer to arrest vomiting, but also the solution tuber of pinellia it
Poison；It is altogether ministerial drug.The pungent scattered temperature of curcuma zedoary is logical, the blood-breaking Eradicates stasis of blood, promoting qi circulation and relieving pain；The sweet temperature of sword bean is supporing yang, warming middle-JIAO for easing the stomach, and drop check is oh；Rattan
The cool heat-clearing of pears root acid, anticancer removing toxic substances；The pungent scattered temperature of rhizoma corydalis is logical, and promoting qi circulation and relieving pain is altogether adjutant.Make with coloured malt stomach strengthening and digestion promoting；Chicken
Interior gold promoting digestion and removing indigestion.With using, tonification and purgation in combination, attacks and does not hurt just for comprehensive full side, air making-up and spleen enlivening medicine and dissolving blood stasis and detoxication medicine；Bitter cold Chinese laxative drugs for removing fire factor
It is pungent to open bitter drop, coordination of cold and heat with pungent-warm eliminating dampness medicine with use；Air making-up and spleen enlivening medicine and treatment for relieving indigestion and constipation qi-activating drug are with using, resolving and invigoration therapies being applied simultaneously, mend without
It is stagnant；The benefits of all medicines share, plays strengthening the spleen and stomach altogether, pungent to open bitter drop, dissolving blood stasis and detoxication, it is wrong effective for the weak fever and chills for the treatment of gastric cancer spleen deficiency stomach
Knot card, significant in efficacy in miscellaneous extravasated blood, and has obtained sufficiently proving through clinical data, and related clinical data is as follows:
1. selecting the standard of case
Pathological diagnosis is the patient of gastric cancer；Tcm diagnosis is that card person is tied in the weak cold-heat jumble extravasated blood of spleen deficiency stomach.
Diagnostic criteria
By pathology or the patients with gastric cancer of cytodiagnosis, basis of stages TNM stage method.
Exclusion criteria
Gestation or breast feeding women；Mental disorder patient；There is language to express obstacle, judgement is lacked to itself symptom
Person；Allergic constitution is known to this explosive component allergy sufferers；Merge intentionally, liver, lung, the severe primaries disease such as kidney and hemopoietic system
Patient.
Therapeutic scheme
The patient point treatment group for being diagnosed as gastric cancer for 120 and control group, control group doctor trained in Western medicine conventional chemotherapy, treatment group are routinizing
Chinese medicine (stomach love relaxation grain) of the present invention is taken orally on the basis for the treatment of daily, each 1 time daily morning and evening, 1-2 bags each, every bag of 5g every 4 weeks is
One period, and conventional anti symptom treatment is given according to the state of an illness, treatment time was four periods, and comprehensive review is carried out after treatment end and is commented
Estimate therapeutic effect.
Efficacy assessment standard
Complete incidence graph (CR): all targeted sites disappear.
Alleviate (PR) in part: baseline lesion major diameter summation reduces 30%.Stable disease (SD): baseline lesion major diameter summation has
It reduces, but not up to PR, or has increase, but not up to PD.
Progression of disease (PD): baseline lesion major diameter summation increases by 20%, or new lesion occurs.
Efficient (%)=(CR+PR+SD)/n × 100%
6. statistical procedures
240 enrolled patients are treated, wherein male patient 156, female patient 84, the age 40-70 years old, press
According to TNM stage, III phase patient 164, IV phase patient 76 is grouped at random, male 38 in control group, and women 22,
III phase patient 40, the IV phase 20, male 40 in treatment group, women 20, III phase patient 42, the IV phase 18.
For statistical analysis to experimental data using computer SPSS(19.0) statistical analysis software, enumeration data uses
X2It examines, measurement data is indicated with mean ± standard deviation.
60 patients, after treating, Objective evaluation is compared as follows (n, %):
| Group | Number of cases | CR | PR | SD | PD | It is efficient |
| Control group | 120 | 0 | 36 | 24 | 60 | 50.00 |
| Treatment group | 120 | 5 | 56 | 37 | 22 | 81.67 |
It is as follows that pretherapy and post-treatment clinical symptoms improve situation:
| Group | Number of cases | Loss of appetite | Nausea and vomiting | Abdominal fullness and distention | Fatigue and asthenia | Loose stool |
| Control group | 120 | 72/116 | 40/88 | 40/104 | 24/80 | 48/76 |
| Treatment group | 120 | 76/84 | 44/52 | 76/84 | 28/48 | 44/40 |
Adverse reaction is found no in this test, shows drug safety of the present invention, and curative effect is reliable and stable.
For more detailed description treatment condition, the curative effect situation of typical case and treatment is given below:
Typical case:
Nanyang City, Henan Province Lee XX, male, 78 years old, upper abdomen distending pain was aggravated with sour regurgitation heartburn more than 4 years with dysphagia 10 days,
On March 23rd, 2018 looks into gastroscope to Henan Prov. People's Hospital and shows: stomach bottom intersection mucous membrane ulcer above covers dunghill, touching
Easy bleeding.Pathological biopsy shows: sdenocarcinoma of stomach.CT shows: thickened stomach wall, considers gastric cancer.Stomach Zhou Duofa enlarged lymph node, it is multiple in liver
Low-density stove considers transfer.Smoking history 40 years, history of drinking more than 30 years；
Tcm diagnosis: gastric cancer (the weak ecchymosis stagnation type of spleen deficiency stomach)
Doctor trained in Western medicine diagnosis: sdenocarcinoma of stomach IV phase
Head examines in patient's private prosecution stomach that sour regurgitation is noisy, and swollen pain of sinking is stuffy, there is a bearing down, dysphagia, has choke to cough up sense, halitosis, usually
Like that eczema out, double lower limb have blutpunkte, sheet, that presses is colour-fast.Therapeutic scheme selects the tegafur, gimeracil and oteracil potassium list medicine chemotherapy combined present invention
Stomach likes relaxation grain.After 2 periods, the noisy mitigation of sour regurgitation in two patient's stomaches when examining gulps down choke and coughs up sense and mitigates, and appetite is poor, double lower limb night
Itch when sleep, still there is blutpunkte.Continue former Regimen Chemotherapy, after 4 periods, three occasionally have sour regurgitation when examining, can without heartburn, no abdominal distension
Feed soft food, lower limb blutpunkte significantly reduces earlier above, and show through CT check: liver inner disease foci disappears, stomach week enlarged lymph node compared with
Before be obviously reduced, during which have no obvious bone marrow suppression and other adverse reactions.
Conclusion
By above situation show the present invention be for treating the active drug for tying card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach,
The benefits of all medicines share, plays strengthening the spleen and stomach altogether, pungent to open bitter drop, dissolving blood stasis and detoxication, has no toxic side effect, it is to control securely and reliably that curative effect, which is stablized,
The innovation in gastric cancer medicament is treated, clinical meaning is huge.
Claims (4)
1. a kind of Chinese medicine for treating knot card in the weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach, which is characterized in that the Chinese medicine is by following
The material medicine of poidometer is made: Radix Codonopsis 10-20g, Rhizoma Atractylodis Macrocephalae 10-20g, curcuma zedoary 8-17g, ginger 3-9g, coptis 2-4g, tuber of pinellia 8-
17g, endothelium corneum gigeriae galli 10-20g, coloured malt 10-20g, rhizoma cyperi 8-17g, rhizoma corydalis 8-17g, sword bean 8-17g and Chinese actinidia root 6-14g,
In, crushing and add Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured for Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, rhizoma corydalis is 70%
Ethanol percolation, at 45-55 DEG C, be concentrated under reduced pressure be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, knife
Beans, the dregs of a decoction of 4 taste medicinal material of rhizoma corydalis and Radix Codonopsis, the coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli
It merges, 4-6 times of the material medicine water measured is added to decoct 2 times, it is 1-2 hours each, merge 2 gained decocting liquids, at 45-55 DEG C
Under, the medicinal extract that preparation relative density is 1.2 is concentrated under reduced pressure, merges 2 medicinal extract being prepared, is dried, crushed into medicinal powder, is added
Auxiliary material, medicinal powder and ratio of adjuvant are 1:2, and it is 80% ethyl alcohol as wetting agent using mass concentration that auxiliary material group, which becomes dextrin-Icing Sugar 1:1,
Uniformly be made softwood, cross the granulation of 20 meshes, 55-65 DEG C is dried, the granulation of 14 mesh sieves, packing to get.
2. the Chinese medicine of knot card in the treatment weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach according to claim 1, which is characterized in that
Be made of the material medicine of following poidometer: Radix Codonopsis 11g, Rhizoma Atractylodis Macrocephalae 19g, curcuma zedoary 9g, ginger 8g, coptis 2g, tuber of pinellia 16g, in chicken
Golden 11g, coloured malt 19g, rhizoma cyperi 9g, rhizoma corydalis 16g, sword bean 9g and Chinese actinidia root 13g, wherein by Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, prolong recklessly
Rope crushes and adds the ethanol percolation that Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured are 70%, at 45 DEG C, decompression
Concentration be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, the dregs of a decoction of 4 taste medicinal material of rhizoma corydalis and Radix Codonopsis,
The coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli merge, and add the water of 4 times of material medicine amounts
It decocts 2 times, 1 hour every time, merges 2 gained decocting liquids, at 45 DEG C, the medicinal extract that preparation relative density is 1.2 is concentrated under reduced pressure, closes
And 2 medicinal extract being prepared, it is dried, crushed into medicinal powder, auxiliary material is added, medicinal powder and ratio of adjuvant are 1:2, and auxiliary material group becomes paste
Essence-Icing Sugar 1:1 is 80% ethyl alcohol as wetting agent using mass concentration, and softwood is uniformly made, and crosses the granulation of 20 meshes, 55 DEG C are done
It is dry, 14 mesh sieves granulation, packing to get.
3. the Chinese medicine of knot card in the treatment weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach according to claim 1, which is characterized in that
Be made of the material medicine of following poidometer: Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 15g, curcuma zedoary 12g, ginger 6g, coptis 3g, tuber of pinellia 12g, in chicken
Golden 15g, coloured malt 15g, rhizoma cyperi 12g, rhizoma corydalis 12g, sword bean 12g and Chinese actinidia root 10g, wherein by Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, prolong
Hu Suo crushes and adds Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, the ethanol percolation that the mass concentration of 5 times of rhizoma corydalis amounts is 70% to depressurize at 50 DEG C
Concentration be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, the dregs of a decoction of 4 taste medicinal material of rhizoma corydalis and Radix Codonopsis,
The coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli merge, and add the water of 5 times of material medicine amounts
It decocts 2 times, 1.5 hours every time, merges 2 gained decocting liquids, at 50 DEG C, the medicinal extract that preparation relative density is 1.2 is concentrated under reduced pressure,
Merge 2 medicinal extract being prepared, be dried, crushed into medicinal powder, auxiliary material is added, medicinal powder and ratio of adjuvant are 1:2, and auxiliary material group becomes
Dextrin-Icing Sugar 1:1 is 80% ethyl alcohol as wetting agent using mass concentration, and softwood is uniformly made, and crosses the granulation of 20 meshes, 60 DEG C are done
It is dry, 14 mesh sieves granulation, packing to get.
4. the Chinese medicine of knot card in the treatment weak cold-heat jumble extravasated blood of gastric cancer spleen deficiency stomach according to claim 1, which is characterized in that
Be made of the material medicine of following poidometer: Radix Codonopsis 19g, Rhizoma Atractylodis Macrocephalae 11g, curcuma zedoary 16g, ginger 4g, coptis 4g, tuber of pinellia 9g, in chicken
Golden 19g, coloured malt 11g, rhizoma cyperi 16g, rhizoma corydalis 9g, sword bean 16g and Chinese actinidia root 7g, wherein by Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, prolong recklessly
Rope crushes and adds the ethanol percolation that Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4-6 times of the rhizoma corydalis mass concentration measured are 70%, at 45-55 DEG C,
Be concentrated under reduced pressure be prepared into relative density be 1.2 medicinal extract, by above-mentioned Rhizoma Atractylodis Macrocephalae, the tuber of pinellia, sword bean, 4 taste medicinal material of rhizoma corydalis the dregs of a decoction with
Radix Codonopsis, the coptis, rhizoma cyperi, ginger, curcuma zedoary, Chinese actinidia root, coloured malt, 8 taste medicinal material of endothelium corneum gigeriae galli merge, and add material medicine 4-6
The water of amount decocts 2 times again, 2 hours every time, merges 2 gained decocting liquids, at 45-55 DEG C, reduced pressure prepares relative density and is
1.2 medicinal extract merges 2 medicinal extract being prepared, and is dried, crushed into medicinal powder, and auxiliary material is added, and medicinal powder and ratio of adjuvant are 1:2,
Auxiliary material group becomes dextrin-Icing Sugar 1:1, is 80% ethyl alcohol as wetting agent using mass concentration, and softwood is uniformly made, and crosses the granulation of 20 meshes,
65 DEG C are dried, 14 mesh sieves granulation, packing to get.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745089A (en) * | 2009-12-16 | 2010-06-23 | 陈正华 | Medicament for treating stomach cancer and preparation method thereof |
| CN102302737A (en) * | 2011-09-06 | 2012-01-04 | 江苏省中医药研究院 | Traditional Chinese medicine composition for treating gastric cancer |
| CN105435099A (en) * | 2015-12-11 | 2016-03-30 | 王平平 | Traditional Chinese medicine for treating superficial gastritis caused by damp heat in spleen and stomach |
| CN105535859A (en) * | 2016-01-27 | 2016-05-04 | 杨甫进 | Traditional Chinese medicine preparation for treating stomach cancer and preparing method thereof |
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2018
- 2018-10-29 CN CN201811267409.4A patent/CN109078163A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745089A (en) * | 2009-12-16 | 2010-06-23 | 陈正华 | Medicament for treating stomach cancer and preparation method thereof |
| CN102302737A (en) * | 2011-09-06 | 2012-01-04 | 江苏省中医药研究院 | Traditional Chinese medicine composition for treating gastric cancer |
| CN105435099A (en) * | 2015-12-11 | 2016-03-30 | 王平平 | Traditional Chinese medicine for treating superficial gastritis caused by damp heat in spleen and stomach |
| CN105535859A (en) * | 2016-01-27 | 2016-05-04 | 杨甫进 | Traditional Chinese medicine preparation for treating stomach cancer and preparing method thereof |
Non-Patent Citations (1)
| Title |
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| 刘景超 等: "平消丹对环磷酰胺化疗增效作用的实验研究", 《江苏中医》 * |
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Application publication date: 20181225 |