CN109077176A - Ferment motherwort composition and its preparation method and application - Google Patents
Ferment motherwort composition and its preparation method and application Download PDFInfo
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- CN109077176A CN109077176A CN201810997546.7A CN201810997546A CN109077176A CN 109077176 A CN109077176 A CN 109077176A CN 201810997546 A CN201810997546 A CN 201810997546A CN 109077176 A CN109077176 A CN 109077176A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The present invention provides a kind of fermentation motherwort compositions and its preparation method and application, are related to Chinese medicine, field of feed.The fermentation motherwort composition is mainly by motherwort, glutinous rice, soya bean, flour, red yeast rice, the raw materials such as koji and water are made, wherein, the fermentation motherwort composition is with red yeast rice, koji is as fermenting microbe, with glutinous rice, soya bean and flour are as fermentation substrate, motherwort and above-mentioned raw materials carry out common fermentation, so that the effective component of motherwort and medicinal efficacy can obviously increase in fermentation motherwort composition, motherwort invigorating qi for strengthening superficies can be improved in obtained fermentation motherwort composition, diuresis, pus draining and toxin expelling, myogenic function, reduce side effect as much as possible again, improve the bioavilability of motherwort, and improve the palatability of motherwort.The present invention also provides the preparation methods of fermentation motherwort composition, the combination by composite bacteria in the different fermentations stage, so that fermentation motherwort composition obtained has good comprehensive performance.
Description
Technical field
The present invention relates to Chinese medicines, field of feed, in particular to a kind of fermentation motherwort composition and its preparation
Methods and applications.
Background technique
Motherwort is the new of Lamiaceae plant motherwort (including white flower motherwort, spire motherwort, Turkey motherwort)
The upper herb of fresh or dry ground, begins to carry Shennong's Herbal, is classified as top grade, is common Chinese medicine.Motherwort acrid flavour, slight bitter, property
Slightly cold, return heart, liver, bladder meridian, have the effect of promoting blood circulation for regulating menstruation, inducing diuresis for removing edema.It is molten that modern medicine study shows that motherwort has
Bolt, drop blood viscosity, reduces erythrocyte aggregation, inhibits platelet aggregation, improving microcirculation, antioxidant radical and subtract anticoagulant, lipid-loweringing
All multiactions such as few intracellular calcium overload.Clinically for irregular menstruation, postpartum stasis caused pain, cardiovascular disease, blood disease etc..
As a kind of obstetrics' conventional Chinese medicine, motherwort is also very common in the application of veterinary clinic, but at present or with tradition
Medicine materical crude slice be used as medicine or as feedstuff add, cost performance is relatively low, while the characteristic of its " bitter taste ", also give clinical application band
Carry out many inconvenience；It has been reported that motherwort has certain toxicity to liver kidney.Therefore, it is being raiseeed to preferably play motherwort
The effect on animal doctor is herded, needs to be processed motherwort by special technique, to improve it in veterinary clinic application
Cost performance and convenience, reduce its toxic side effect as far as possible.
In view of this, the present invention is specifically proposed at least one of to solve the above technical problems.
Summary of the invention
The first purpose of this invention is to provide a kind of fermentation motherwort composition, which can
Improve the function of motherwort promoting blood circulation for regulating menstruation, inducing diuresis to remove edema, moreover it is possible to liver kidney side effect is reduced, the bioavilability of motherwort is improved,
And improve the palatability at motherwort end.
Second object of the present invention is to provide a kind of preparation method of motherwort composition that ferments, preparation method letter
It is single easy, it is suitable for industrially being mass produced.
Third object of the present invention is to provide a kind of application of motherwort composition that ferments.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
The present invention provides a kind of fermentation motherwort composition, is mainly prepared from the following raw materials in parts by weight: motherwort 180
~220 parts, 8~12 parts of glutinous rice, 7.5~12.5 parts of soya bean, 2.5~7.5 parts of flour, 1~6 part of red yeast rice, 1~6 part of koji and
20~300 parts of water.
As a kind of preferred embodiment of the present invention, the fermentation motherwort composition is mainly by the original of following parts by weight
Material is made: 185~215 parts of motherwort, 8.5~11.5 parts of glutinous rice, and 8~12 parts of soya bean, 3~7 parts of flour, 1~5 part of red yeast rice, sweet tea
1~5 part and 30~260 parts of water of distiller's yeast.
As a kind of preferred embodiment of the present invention, the fermentation motherwort composition is mainly by the original of following parts by weight
Material is made: 190~210 parts of motherwort, 9~11 parts of glutinous rice, and 8.5~11 parts of soya bean, 4~6 parts of flour, 2~5 parts of red yeast rice, sweet wine
Bent 2~5 parts and 40~220 parts of water.
The present invention also provides a kind of preparation methods of motherwort composition that ferments, comprising the following steps:
(a) the yellow rice wine wine obtained the red koji fermentation of the glutinous rice of formula ratio, the water of part formulation amount and formula ratio and part
The koji mixing of the motherwort, part formulation amount of formula ratio, ferments again, obtains fermentation material one；
(b) soya bean that the flour of the soya bean of formula ratio, the water of remaining formula ratio and formula ratio ferments is made and residue
The koji mixing of the motherwort of formula ratio, remaining formula ratio, ferments again, obtains fermentation material two；
(c) fermentation material one and fermentation material two are mixed, obtains fermentation motherwort composition.
As a kind of preferred embodiment of the present invention, in step (a), the glutinous rice of formula ratio is added to part formulation amount
It in water, impregnates, cooks, be cooled to room temperature and ferment again with the mixing of the red yeast rice of formula ratio；
Preferably, fermentation temperature when glutinous rice, water and red yeast rice are fermented in step (a) is 25~33 DEG C, fermentation time
It is 25~40 days.
As a kind of preferred embodiment of the present invention, the mesh number of motherwort is 200~300 mesh in step (a)；
Preferably, it is 25~33 that yellow rice wine, which makes fermentation temperature when being fermented again with motherwort, koji, in step (a)
DEG C, fermentation time is 5~15 days.
As a kind of preferred embodiment of the present invention, in step (b), the soya bean of formula ratio is added to remaining formula ratio
It in water, impregnates, cooks, be cooled to room temperature and ferment again with the mixing of the flour of formula ratio；
Preferably, fermentation temperature when soya bean, water and flour are fermented in step (b) is 18~25 DEG C, fermentation time
It is 2~3 days.
As a kind of preferred embodiment of the present invention, in step (b), the mesh number of motherwort is 200~300 mesh；
Preferably, it is 18~25 that soya bean, which makes fermentation temperature when being fermented again with motherwort, koji, in step (b)
DEG C, fermentation time is 5~15 days.
As a kind of preferred embodiment of the present invention, in step (c), will fermentation material one and fermentation material two mix after it is dry,
Obtain fermentation motherwort composition；
Preferably, drying temperature is 45~55 DEG C in step (c), and the dry moisture into fermentation motherwort composition is lower than
10%.
The present invention also provides above-mentioned fermentation motherwort composition or using the preparation method system of fermentation motherwort composition
Application of the fermentation motherwort composition obtained in Chinese medicine or feed.
Compared with prior art, fermentation motherwort composition provided by the invention and preparation method thereof has below beneficial to effect
Fruit:
(1) the present invention provides a kind of fermentation motherwort compositions, mainly by motherwort, glutinous rice, soya bean, flour, red yeast rice,
The raw materials such as koji and water are made, wherein the fermentation motherwort composition using red yeast rice, koji as fermenting microbe, with glutinous rice,
Soya bean and flour are as fermentation substrate, motherwort and above-mentioned raw materials progress common fermentation, so that in fermentation motherwort composition
The effective component and medicinal efficacy of motherwort can obviously increase, and it is living that motherwort can be improved in obtained fermentation motherwort composition
Blood menstruation regulating, inducing diuresis to remove edema function, moreover it is possible to reduce liver kidney side effect, improve the bioavilability of motherwort, and improve motherwort
The palatability at end.
It (2) is to send out glutinous rice altogether with red yeast rice first the present invention provides a kind of preparation method of motherwort composition that ferments
Ferment is made that yellow rice wine is made and soya bean and flour spontaneous fermentation are made soya bean and make, yellow rice wine obtained above make and soya bean wine with benefit
Brittle Falsepimpernel Herb, koji ferment again obtains fermentation material one and fermentation material two, and fermentation material one and fermentation material two are mixed to get fermentation benefit
Brittle Falsepimpernel Herb composition.The preparation method uses ferments stage by stage, and uses different fermenting microbes during the fermentation, i.e., logical
Composite bacteria is crossed in the combination in different fermentations stage, may make the motherwort in fermentation motherwort composition obtained it is effective at
Dividing can increase considerably, while reduce the side effect of motherwort again, improve the bioavilability and palatability of motherwort.
In addition, the preparation method simple process, convenient to carry out, be conducive to industrial large-scale processing production.
(3) the present invention provides the application of fermentation motherwort composition, had in view of above-mentioned fermentation motherwort composition
Advantage so that its as Chinese medicine or as can feeding natural plants in Chinese medicine or field of fodder have good application.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to the first aspect of the invention, a kind of fermentation motherwort composition is provided, mainly by following parts by weight
Raw material be made: 180~220 parts of motherwort, 8~12 parts of glutinous rice, 7.5~12.5 parts of soya bean, 2.5~7.5 parts of flour, red yeast rice 1
~6 parts, 1~6 part and 20~300 parts of water of koji.
The present invention provides a kind of fermentation motherwort compositions, mainly by motherwort, glutinous rice, soya bean, flour, red yeast rice, sweet tea
The raw materials such as distiller's yeast and water are made, wherein red yeast rice, koji as fermenting microbe, glutinous rice, soya bean and flour as fermentation substrate,
Under the mating reaction of above-mentioned each raw material, motherwort is made to the form of fermentation motherwort composition, so that in motherwort
Effective component and medicinal efficacy can obviously increase, and that motherwort tonifying Qi can be improved is solid for obtained fermentation motherwort composition
Table, diuresis, pus draining and toxin expelling, myogenic function, while also can effectively reduce side effect, the bioavilability of motherwort is improved, and
Improve the palatability of motherwort.
Specifically, motherwort is as the main composition in the fermentation motherwort composition, by the way that motherwort to be made
The form of fermentation motherwort composition, can greatly promote the dissolution of the effective component of motherwort, be conducive to the enhancing of medicinal efficacy,
Mitigate motherwort side effect adverse effect itself simultaneously, improve motherwort as Chinese medicine or can feeding natural plants exist
Intracorporal bioavilability, while the mouthfeel of motherwort is improved, significantly improve its palatability.Motherwort is typical but unrestricted
Property parts by weight be 180 parts, 185 parts, 190 parts, 195 parts, 200 parts, 210 parts or 220 parts.
In the present invention, glutinous rice, soya bean and flour provide nutrition and energy as fermentation substrate for the growth of thallus
Deng.
The used in amounts of fermentation substrate controls in certain amount ranges.The typical but non-limiting parts by weight of glutinous rice are 8
Part, 9 parts, 10 parts, 11 parts or 12 parts；The typical but non-limiting parts by weight of soya bean be 7.5 parts, 8 parts, 9 parts, 10 parts, 11 parts,
12 parts or 12.5 parts；The typical but non-limiting parts by weight of flour are 2.5 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 7.5 parts.
Red yeast rice be the mycelium of Aspergillaceae fungi monascus Monascus purpureus Went. colonize on polished rice and
At red yeast rice.The typical but non-limiting parts by weight of red yeast rice are 1 part, 2 parts, 3 parts, 4 parts, 5 parts or 6 parts.
Koji is saccharolytic and yeast preparation, contained by microorganism mainly have head mold, Mucor and a small amount of yeast.Sweet wine
Bent typical but non-limiting parts by weight are 1 part, 2 parts, 3 parts, 4 parts, 5 parts or 6 parts.
After red yeast rice and koji are mixed as strain with motherwort, the fermentation of motherwort can promote, promote motherwort effective
The dissolution of ingredient, meanwhile, the metabolite of strain can also enrich and be promoted the medicinal efficacy of motherwort in fermentation process.
The typical but non-limiting parts by weight of water be 20 parts, 50 parts, 80 parts, 100 parts, 120 parts, 140 parts, 150 parts,
160 parts, 180 parts, 200 parts, 220 parts, 240 parts, 260 parts, 280 parts or 300 parts.
" mainly by ... be made " of the present invention, it is intended that it can also include other raw materials in addition to the raw material, than
Such as say other traditional Chinese medicinal components, these other components assign the fermentation motherwort composition different characteristics.In addition to this, originally
Invention " mainly by ... be made ", may be replaced by enclosed " for " or " by ... be made ".
As a kind of preferred embodiment of the present invention, the fermentation motherwort composition is mainly by the original of following parts by weight
Material is made: 185~215 parts of motherwort, 8.5~11.5 parts of glutinous rice, and 8~12 parts of soya bean, 3~7 parts of flour, 1~5 part of red yeast rice, sweet tea
1~5 part and 30~260 parts of water of distiller's yeast.
Preferably, the fermentation motherwort composition is mainly prepared from the following raw materials in parts by weight: motherwort 190~
210 parts, 9~11 parts of glutinous rice, 8.5~11 parts of soya bean, 4~6 parts of flour, 2~5 parts of red yeast rice, 2~5 parts of koji and water 40~220
Part.
By being further limited to each raw material dosage in the fermentation motherwort composition, so that the cooperation between each raw material
Act on it is more significant, ferment motherwort composition effectiveness it is more prominent.
It should be noted that the fermentation motherwort composition can be fabricated to different dosage forms, such as tablet, pill, particle
Agent, pulvis, capsule etc., are not particularly limited herein.
According to the second aspect of the invention, additionally provide it is a kind of ferment motherwort composition preparation method, including with
Lower step:
(a) the yellow rice wine wine obtained the red koji fermentation of the glutinous rice of formula ratio, the water of part formulation amount and formula ratio and part
The koji mixing of the motherwort, part formulation amount of formula ratio, ferments again, obtains fermentation material one；
(b) soya bean that the flour of the soya bean of formula ratio, the water of remaining formula ratio and formula ratio ferments is made and residue
The koji mixing of the motherwort of formula ratio, remaining formula ratio, ferments again, obtains fermentation material two；
(c) fermentation material one and fermentation material two are mixed, obtains fermentation motherwort composition.
The preparation method of fermentation motherwort composition provided by the invention, is that Huang is made in glutinous rice and red yeast rice common fermentation first
Fermented glutinous rice and soya bean and flour spontaneous fermentation are made soya bean and make, yellow rice wine obtained above make and soya bean wine with motherwort, sweet wine
Qu Zaici ferments to obtain fermentation material one and fermentation material two, and fermentation material one and fermentation material two are mixed to get fermentation motherwort combination
Object.The preparation method uses ferments stage by stage, and uses different fermenting microbes during the fermentation, that is, passes through compound bacteria
Combination of the kind in the different fermentations stage may make that the effective component of the motherwort in fermentation motherwort composition obtained can be substantially
Degree increases, while reducing the side effect of motherwort again, improves the bioavilability and palatability of motherwort.
In addition, the preparation method simple process, convenient to carry out, be conducive to industrial large-scale processing production.
Yellow rice wine is made or soya bean wine is fragrant and sweet, when fermenting again with motherwort, koji respectively, can be effectively improved beneficial mother
The bad mouthfeel of grass, and then improve the palatability of fermentation motherwort composition.
As a kind of preferred embodiment of the present invention, in step (a), the glutinous rice of formula ratio is added to part formulation amount
It in water, impregnates, cooks, be cooled to room temperature and ferment again with the mixing of the red yeast rice of formula ratio.
Preferably, fermentation temperature when glutinous rice, water and red yeast rice are fermented in step (a) is 25~33 DEG C, fermentation time
It is 25~40 days.
Glutinous rice, water and red yeast rice when being fermented typical but non-limiting fermentation temperature be 25 DEG C, 26 DEG C, 27 DEG C, 28 DEG C,
29 DEG C, 30 DEG C, 31 DEG C, 32 DEG C or 33 DEG C.Typical but non-limiting fermentation time be 25 days, 26 days, 28 days, 30 days, 32 days,
34 days, 35 days, 36 days, 38 days or 40 days.
Fermentation temperature and fermentation when being fermented by the restriction and glutinous rice of the pre-treatment step to glutinous rice, water and red yeast rice
The restriction of time, so that glutinous rice reaches good ferment effect under the action of red yeast rice.
As a kind of preferred embodiment of the present invention, the mesh number of motherwort is 200~300 mesh in step (a)；
Preferably, it is 25~33 that yellow rice wine, which makes fermentation temperature when being fermented again with motherwort, koji, in step (a)
DEG C, fermentation time is 5~15 days.
It is 25 DEG C, 26 that yellow rice wine, which makes typical but non-limiting fermentation temperature when being fermented again with motherwort, koji,
DEG C, 27 DEG C, 28 DEG C, 29 DEG C, 30 DEG C, 31 DEG C, 32 DEG C or 33 DEG C.Typical but non-limiting fermentation time be 5 days, 6 days, 8 days,
10 days, 12 days, 14 days or 15 days.
Fermentation time and fermentation temperature have attenuation degree important influence, by fermentation time and fermentation temperature
It limits, so that yellow rice wine is made when being fermented again with motherwort, koji, suitable attenuation degree can be reached.
As a kind of preferred embodiment of the present invention, in step (b), the soya bean of formula ratio is added to remaining formula ratio
It in water, impregnates, cooks, be cooled to room temperature and ferment again with the mixing of the flour of formula ratio；
Preferably, fermentation temperature when soya bean, water and flour are fermented in step (b) is 18~25 DEG C, fermentation time
It is 2~3 days.
Soya bean, water and flour when being fermented typical but non-limiting fermentation temperature be 18 DEG C, 19 DEG C, 20 DEG C, 21 DEG C,
22 DEG C, 23 DEG C, 24 DEG C or 25 DEG C.Typical but non-limiting fermentation time is 2 days or 3 days.
As a kind of preferred embodiment of the present invention, in step (b), the mesh number of motherwort is 200~300 mesh；
Preferably, it is 18~25 that soya bean, which makes fermentation temperature when being fermented again with motherwort, koji, in step (b)
DEG C, fermentation time is 5~15 days.
It is 18 DEG C, 19 that soya bean, which makes typical but non-limiting fermentation temperature when being fermented again with motherwort, koji,
DEG C, 20 DEG C, 21 DEG C, 22 DEG C, 23 DEG C, 24 DEG C or 25 DEG C.Typical but non-limiting fermentation time be 5 days, 6 days, 8 days, 10 days,
12 days, 14 days or 15 days.
As a kind of preferred embodiment of the present invention, in step (c), will fermentation material one and fermentation material two mix after it is dry,
Obtain fermentation motherwort composition；
Preferably, drying temperature is 45~55 DEG C in step (c), and the dry moisture into fermentation motherwort composition is lower than
10%.
Typical but non-limiting drying temperature is 45 DEG C, 46 DEG C, 48 DEG C, 49 DEG C, 50 DEG C, 51 DEG C, 52 in step (c)
DEG C, 53 DEG C, 54 DEG C or 55 DEG C.
The subsequent fermentation of fermentation material one and fermentation material two is also achieved in fermentation material one and two combination drying process of fermentation material,
To reach good attenuation degree.
It should be noted that different according to specific aftertreatment technology, which can be fabricated to difference
Dosage form, such as tablet, pill, granule, pulvis, capsule etc..
In addition, the preparation method use production equipment be routine, do not need separately to install it is standby, and whole preparation process letter
It is single easy, it is suitable for industrially being mass produced.
According to the third aspect of the present invention, above-mentioned fermentation motherwort composition is additionally provided or using fermentation motherwort group
Close application of the preparation method fermentation motherwort composition obtained of object in Chinese medicine or feed.
In view of advantage possessed by above-mentioned fermentation motherwort composition, so that it is as Chinese medicine or as can be feeding natural
Plant has good application in Chinese medicine or field of fodder.
Combined with specific embodiments below and comparative example, the invention will be further described.Wherein, red yeast rice is purchased from Hebei Lin Shi
Prepared slices of Chinese crude drugs Co., Ltd, motherwort are purchased from Palestine and China Cologne prepared slices of Chinese crude drugs Co., Ltd, and koji has purchased from Angel Yeast share
Limit company.
Embodiment 1
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 10 parts of glutinous rice, 10 parts of soya bean, 5 parts of flour, 3 parts of red yeast rice, 2 parts and 60 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, comprising the following steps:
(a) glutinous rice of 10 parts by weight is added in the water of 30 parts by weight, impregnate, cook, after airing to room temperature again with 3 weights
The red yeast rice for measuring part carries out mixed fermentation, and fermentation temperature is 26 DEG C, and fermentation time is 30 days, obtains yellow rice wine wine；
The motherwort of 100 parts by weight is crushed to mix after 200 mesh impalpable powders with the koji of yellow rice wine wine and 1 parts by weight,
It ferments again, fermentation temperature is 26 DEG C again, and fermentation time is 10 days again, obtains fermentation material one；
(b) by the soya bean decladding of 10 parts by weight and crush be 8 mesh particles after be added in the water of 30 parts by weight, impregnate, steam
It is ripe, it is mixed again with the flour of 5 parts by weight after airing to room temperature, sets and spread out on thin bamboo strips used for weaving, kept 3cm left and right thickness, cover cotton, set
It ferments in shady and cool library, fermentation temperature is 25 DEG C, and fermentation time is 2 days, obtains soya bean wine；
The motherwort of 100 parts by weight is crushed to mix after 200 mesh impalpable powders with the koji of soya bean wine and 1 parts by weight,
It ferments again, fermentation temperature is 25 DEG C again, and fermentation time is 10 days again, obtains fermentation material two；
(c) fermentation material one and fermentation material two are uniformly mixed, are prepared into 20 mesh fine graineds with granulator, extremely in 55 DEG C of dryings
Moisture content is lower than 10%, obtains fermentation motherwort composition.
Embodiment 2
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 8 parts of glutinous rice, 12 parts of soya bean, 7 parts of flour, 5 parts of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, comprising the following steps:
(a) glutinous rice of 8 parts by weight is added in the water of 50 parts by weight, impregnate, cook, after airing to room temperature again with 5 weights
The red yeast rice for measuring part carries out mixed fermentation, and fermentation temperature is 30 DEG C, and fermentation time is 40 days, obtains yellow rice wine wine；
The motherwort of 100 parts by weight is crushed to mix after 300 mesh impalpable powders with the koji of yellow rice wine wine and 1 parts by weight,
It ferments again, fermentation temperature is 30 DEG C again, and fermentation time is 15 days again, obtains fermentation material one；
(b) by the soya bean decladding of 12 parts by weight and crush be 8 mesh particles after be added in the water of 50 parts by weight, impregnate, steam
It is ripe, it is mixed again with the flour of 7 parts by weight after airing to room temperature, sets and spread out on thin bamboo strips used for weaving, kept 3cm left and right thickness, cover cotton, set
It ferments in shady and cool library, fermentation temperature is 30 DEG C, and fermentation time is 3 days, obtains soya bean wine；
The motherwort of 100 parts by weight is crushed to mix after 200 mesh impalpable powders with the koji of soya bean wine and 5 parts by weight,
It ferments again, fermentation temperature is 30 DEG C again, and fermentation time is 15 days again, obtains fermentation material two；
(c) fermentation material one and fermentation material two are uniformly mixed, are prepared into 20 mesh fine graineds with granulator, extremely in 45 DEG C of dryings
Moisture content is lower than 10%, obtains fermentation motherwort composition.
Embodiment 3
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 9 parts of glutinous rice, 11 parts of soya bean, 7 parts of flour, 4 parts of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, the middle koji used of step (a)
Parts by weight are 2 parts, and the parts by weight of the koji used in step (b) is 4 parts, remaining step and parameter and embodiment 2
It is identical.
Embodiment 4
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 10 parts of glutinous rice, 10 parts of soya bean, 5 parts of flour, 3 parts of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, the middle koji used of step (a)
Parts by weight are 3 parts, and the parts by weight of the koji used in step (b) is 3 parts, remaining step and parameter and embodiment 2
It is identical.
Embodiment 5
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 11 parts of glutinous rice, 9 parts of soya bean, 4 parts of flour, 2 parts of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, the middle koji used of step (a)
Parts by weight are 4 parts, and the parts by weight of the koji used in step (b) is 2 parts, remaining step and parameter and embodiment 2
It is identical.
Embodiment 6
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 12 parts of glutinous rice, 8 parts of soya bean, 3 parts of flour, 1 part of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, the middle koji used of step (a)
Parts by weight are 5 parts, and the parts by weight of the koji used in step (b) is 1 parts, remaining step and parameter and embodiment 2
It is identical.
Embodiment 7
The present embodiment provides a kind of fermentation motherwort compositions, are mainly prepared from the following raw materials in parts by weight: motherwort
180 parts, 10 parts of glutinous rice, 10 parts of soya bean, 5 parts of flour, 4 parts of red yeast rice, 5 parts and 200 parts of water of koji.
A kind of preparation method of motherwort composition that ferments provided in this embodiment, the middle motherwort used of step (a)
Parts by weight are 90 parts, and the parts by weight of koji are 1 part, and the parts by weight that water is added are 100 parts, are used in step (b)
The parts by weight of motherwort are 90 parts, and the parts by weight of koji are 4 parts, and the parts by weight that water is added are 100 parts, remaining step
And parameter is same as Example 2.
Comparative example 1
This comparative example provides a kind of fermentation motherwort composition, is mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 7 parts of glutinous rice, 13 parts of soya bean, 8 parts of flour, 5 parts of red yeast rice, 6 parts of koji, 100 parts of water.
A kind of preparation method for fermentation motherwort composition that this comparative example provides, the weight of the middle glutinous rice used of step (a)
Measuring number is 7 parts, and the parts by weight of the soya bean used in step (b) is 13 parts, and the parts by weight of flour are 8 parts, remaining step
And parameter is same as Example 2.
Comparative example 2
This comparative example provides a kind of fermentation motherwort composition, is mainly prepared from the following raw materials in parts by weight: motherwort
200 parts, 13 parts of glutinous rice, 7 parts of soya bean, 2 parts of flour, 1 part of red yeast rice, 6 parts and 100 parts of water of koji.
A kind of preparation method for fermentation motherwort composition that this comparative example provides, the weight of the middle glutinous rice used of step (a)
Measuring number is 13 parts, and the parts by weight of the soya bean used in step (b) is 7 parts, and the parts by weight of flour are 2 parts, remaining step
And parameter is same as Example 2.
In order to further verify the effect of above-described embodiment and comparative example, ad hoc following experimental example.
1 effect experiment of experimental example
Experimental method: taking sow due to farrow 220, is randomly divided into 11 groups, respectively blank group, control group, experimental group 1-7 and
Contrast groups 1-2.The fermentation motherwort combination for the embodiment 1-7 that mass fraction is 1% is added in experimental group 1-7 sow feed respectively
Object；The fermentation motherwort composition for the comparative example 1-2 that mass fraction is 1% is added in contrast groups 1-2 sow feed respectively；Control
The motherwort that addition mass fraction is 1% in group sow feed is last, the rice that addition mass fraction is 1% in blank group sow feed
Careless end；It is fed before sows farrowing 5 days, postpartum feeds 7 days, and in addition to feed, other rearing conditions are identical；Each group is observed and recorded respectively
Sow is averaged stages of labor (average stages of labor, abbreviation ASL), prolonged lochia (prolonged lochia,
Abbreviation PL) disease incidence, sow postpartum triad (intimitis, mammitis, agalasisa and lactation are insufficient in uterus, abbreviation MMA) morbidity
Rate and piglet disease incidence and piglet daily gain average value (ADG)；
Record each group relevant evaluation index, compared with the control group by the result of experimental group, one of index better than pair
According to a "+" is organized to obtain, quite then ignore with control group, quite or is worse than control group with blank group and is then chosen as "-", a "+" one
A "-" is cancelled out each other, and the results are shown in Table 1.
The postpartum health care functional evaluation result of 1 different experiments group of table and contrast groups
As shown in Table 1, the average stages of labor of experimental group 1-7, PL disease incidence, MMA disease incidence and piglet disease incidence and piglet day
Weight gain average value is superior to control group and blank group.The fermentation motherwort composition of various embodiments of the present invention preparation can mention significantly
High postpartum health care for sows function.And 2 postpartum health care function of contrast groups is suitable with control group, illustrates different material combinations to fermentation
The function curative effect of motherwort composition has an impact, and different material combinations fall ill to ASL, PL disease incidence, MMA disease incidence, piglet
The influence of rate and piglet ADG are different.
2 toxicological experiment of experimental example
Experimental animal: Kunming mouse, SPF grades, 18~22g of weight, half male and half female, totally 110, by medicine section of Sichuan Province
Institute's Experimental Animal Center provides, animal certificate number SYXK (army) 2002-005.Animal feeding is in barrier animal room, animal house
Quality certification number SYXK (army) 2002-005.Room temperature (20 ± 2) DEG C, relative humidity 60~70%, well-ventilated, environment quiet, room
Interior holding 12h illumination, 12h is dark, and periodically sterilizes.
Experimental method: mouse is randomly divided into 11 groups, respectively blank group, control group and experimental group 1-7 (corresponding embodiment
1-7 group) and contrast groups 1-2 (corresponding comparative example 1-2), every group 10, half male and half female.
Control group presses 38gkg-1Daily dosage stomach-filling motherwort end suspension, experimental group 1-7 and contrast groups 1-2 are pressed
38g·kg-1The fermentation motherwort composition suspension that provides of daily dosage difference stomach-filling embodiment 1-7 and comparative example 1-2, it is empty
The capacity distilled water such as white group of stomach-filling；Even fill 14 days；The free diet of animal during administration, the appearance of daily observation administration front and back animal
Sign, the variation of behavioral activity hair, stool and urine shape, color, whether there is or not abnormal secretions etc. for eye, ear, mouth, nose, anus.Exist respectively
Administration 0,1,3,7,11,14d weighing the weight of animals, calculate growth rate.After successive administration 14d, mouse plucks eyeball and takes blood, separates blood
Clearly, glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminease (AST), urea nitrogen (BUN), inosine (CREA), alkaline phosphatase are detected
(ALP), total protein (TP), albumin (ALB), globulin (GLO), A/G, total bilirubin (TBIL), glucose (Glu), total gallbladder
Sterol (CHOL) index.Animal is put to death after taking blood, is carried out to the heart, liver and spleen, lung, kidney, brain, sexual gland, thyroid gland, thymus gland, ileum etc.
It visually observes, weigh and calculates organ coefficient.Liver, nephridial tissue are taken, is fixed with 10% neutral formalin solution, it is de- through graded ethanol
The transparent paraffin embedding of water, dimethylbenzene, slice (4~5 μm thick), HE are dyed, and observe histopathologic change under optical microscopy.
2 different experiments group of table and contrast groups are to liver side effect evaluation result
3 different experiments group of table and contrast groups are to renal adverse effects evaluation result
| Test group | BUN/mmol·L-1 | CREA/μmol·L-1 | Overall merit |
| Experimental group 1 | 7.06±1.72 | 54.28±8.48 | Normally |
| Experimental group 2 | 6.48±2.43 | 55.60±7.68 | Normally |
| Experimental group 3 | 7.44±2.24 | 56.76±9.40 | Normally |
| Experimental group 4 | 7.44±1.84 | 54.33±8.45 | Normally |
| Experimental group 5 | 6.89±2.42 | 54.30±4.79 | Normally |
| Experimental group 6 | 6.67±2.65 | 54.49±8.20 | Normally |
| Experimental group 7 | 6.88±2.24 | 55.13±7.54 | Normally |
| Contrast groups 1 | 7.64±1.75 | 55.38±7.39 | Normally |
| Contrast groups 2 | 7.07±2.24 | 55.39±5.75 | Normally |
| Blank group | 6.68±1.24 | 54.92±7.84 | Normally |
| Control group | 7.88±2.26 | 58.82±10.63 | It is faint |
By data in table 2 and 3 as it can be seen that each group is without dead example, general signs no abnormality seen.
The results show that ALT, AST, BUN, CREA index of each administration group have different degrees of change, wherein contrast groups 1
Mouse Liver kidney side effect is suitable with control group, and liver/kidney side effect is chosen as " faint ", and other experimental groups are not shown with blank group difference
It writes, liver/kidney side effect is chosen as " normal ".The variation of the indexs such as ALP, ALB, TP, GLO, A/G, TBIL, CHOL, Glu is unobvious.From
Result can be seen that the successive administration 14d under higher dosage in table 2 and 3, remove 1 Mouse Liver kidney side effect of contrast groups and control group
Quite outer, other each group Mouse Liver kidney side effects are respectively less than control group, as a result illustrate, fermentation auxiliary material combination difference is female to fermentation benefit
The liver kidney side effect of careless composition has different influences.
Consolidated statement 2-3 analysis, the mouse hepatic and renal function of experimental group 1-7 get a promotion, and liver kidney side effect is weakened or disappeared
It removes.The experimental results showed that fermentation motherwort composition provided by the invention has the function of Synergy and attenuation relative to motherwort end
Effect.
3 Palatability evaluation of experimental example
It takes motherwort last, is freely eaten by the dosage spice that mass fraction is 1% for healthy swinery, be control group；Take reality
The fermentation motherwort composition that a 1-7 and comparative example 1-2 is provided is applied, the dosage spice for being respectively 1% by mass fraction is for health
Swinery is freely eaten；If blank group feeds chow diet；Record feeding situation.
Corresponding to palatability using blank group feed intake is " general " as benchmark is judged, is divided into following level: excellent: with blank group
It compares, feed intake increases；Difference: compared to the blank group, feed intake decline；General: compared to the blank group, feed intake is unchanged.
It is searched for food the palatability of situation evaluation corresponding product according to each group, evaluation criterion and the results are shown in Table 4.
4 different experiments group of table and contrast groups Palatability evaluation standard and result
| Grouping | Evaluation result |
| Experimental group 1 | It is excellent |
| Experimental group 2 | Generally |
| Experimental group 3 | It is excellent |
| Experimental group 4 | It is excellent |
| Experimental group 5 | Generally |
| Experimental group 6 | It is excellent |
| Experimental group 7 | It is excellent |
| Contrast groups 1 | Difference |
| Contrast groups 2 | It is excellent |
| Blank group | Generally |
| Control group | Difference |
The results show that influence of the different material combinations to fermentation motherwort composition palatability is different, and this shadow
Ring not shown regularity.
5 different experiments group of table and contrast groups Quality evaluation result
Consolidated statement 1-5 analysis, since contrast groups 1 are performed poor in terms of reducing the side effect of liver kidney and palatability, although its
Postpartum health care effect is fine, and overall merit is still " poor "；Contrast groups 2 show not in terms of reducing the side effect of liver kidney and palatability
Mistake, but its postpartum health care poor effect, overall merit are still " poor "；Other group Quality evaluations are " excellent ".
Control efficiency of the fermentation motherwort composition of experimental example 4 to multisystem exhaustion syndrome (PMWS)
Material: motherwort end (Chengdu universe animal pharmaceutical estate limited liability company)；Motherwort composition ferment (only to implement
Example 5 is representative)；
Test pig farm: the multiple pig farm Shuangliu County postweaning multisystem exhaustion syndrome (PMWS).
Method: pig farm milking sow 27 are randomly selected under identical rearing conditions, is divided into experimental group, positive control
Group and negative control group (every group 9)；Experimental group presses mass fraction using fermentation motherwort composition prepared by embodiment 5
1.0% spice is fed, and positive controls are that 1.0% spice is fed by mass fraction with motherwort end, each continuous use in wean front and back
Medicine 7 days；Negative control group is raised by daily feeding manner, is not administered；PMWS incidence is recorded, the results are shown in Table 6.
The control efficiency of 6 different experiments group of table and contrast groups to pig PMWS
| Test group | PMWS disease incidence (%) |
| Experimental group | 0 |
| Positive controls | 11 |
| Negative control group | 27 |
The result shows that experimental group is better than other groups to the control efficiency of pig PMWS, the motherwort composition that illustrates to ferment is to pig
The control efficiency of PMWS is better than motherwort end.
Influence of the fermentation motherwort composition of experimental example 6 to pig farm RSY
Material: motherwort end (Chengdu universe animal pharmaceutical estate limited liability company)；Motherwort composition ferment (only to implement
Example 5 is representative)；
Test pig farm: Shuangliu County home-bred and autophytic pig farm.
Method: sow is divided into experimental group, control group and blank group (every group 9) at random under the same conditions；Experimental group
The fermentation motherwort composition prepared with embodiment 5 is that 1.0% spice is fed by mass fraction, positive controls motherwort end
It is that 1.0% spice is fed by mass fraction, antenatal continuous use 5 days, postpartum continuous use 15 days；Experimental group piglet embodiment
The fermentation motherwort composition of 5 preparations is that 1.0% spice is fed by mass fraction, and positive controls piglet presses matter with motherwort end
Amount score is that 1.0% spice is fed, continuous use 5 days, continuous use 10 days after wean before weaning；Negative control group presses daily feeding
Feeding mode is raised, and is not administered；Record each group is always put into and Gross Output, calculates RSY (single head sow year rate of return on investment), RSY=
(Gross Output-is always put into)/total investment, concrete outcome are shown in Table 7.
The influence result of 7 different experiments group of table and contrast groups to pig farm RSY
| Test group | RSY (%) |
| Experimental group | 21.6 |
| Positive controls | 10.1 |
| Negative control group | 5.6 |
The result shows that experimental group is better than other groups in terms of improving pig farm RSY, illustrate that fermentation motherwort composition is improving
Effect in terms of the RSY of pig farm is better than motherwort end.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of fermentation motherwort composition, which is characterized in that be mainly prepared from the following raw materials in parts by weight: motherwort 180
~220 parts, 8~12 parts of glutinous rice, 7.5~12.5 parts of soya bean, 2.5~7.5 parts of flour, 1~6 part of red yeast rice, 1~6 part of koji and
20~300 parts of water.
2. fermentation motherwort composition according to claim 1, which is characterized in that mainly by the raw material of following parts by weight
It is made: 185~215 parts of motherwort, 8.5~11.5 parts of glutinous rice, 8~12 parts of soya bean, 3~7 parts of flour, 1~5 part of red yeast rice, sweet wine
Bent 1~5 part and 30~260 parts of water.
3. fermentation motherwort composition according to claim 1, which is characterized in that mainly by the raw material of following parts by weight
It is made: 190~210 parts of motherwort, 9~11 parts of glutinous rice, 8.5~11 parts of soya bean, 4~6 parts of flour, 2~5 parts of red yeast rice, koji 2
~5 parts and 40~220 parts of water.
4. the preparation method of fermentation motherwort composition according to any one of claims 1 to 3, which is characterized in that packet
Include following steps:
(a) the yellow rice wine wine and part formulation obtained the red koji fermentation of the glutinous rice of formula ratio, the water of part formulation amount and formula ratio
The koji mixing of the motherwort, part formulation amount of amount, ferments again, obtains fermentation material one；
(b) soya bean that the flour of the soya bean of formula ratio, the water of remaining formula ratio and formula ratio ferments is made and is formulated with remaining
The koji mixing of the motherwort of amount, remaining formula ratio, ferments again, obtains fermentation material two；
(c) fermentation material one and fermentation material two are mixed, obtains fermentation motherwort composition.
5. the preparation method of fermentation motherwort composition according to claim 4, which is characterized in that in step (a), will match
The glutinous rice just measured is added in the water of part formulation amount, is impregnated, is cooked, and is cooled to room temperature and is mixed progress with the red yeast rice of formula ratio again
Fermentation；
Preferably, fermentation temperature when glutinous rice, water and red yeast rice are fermented in step (a) is 25~33 DEG C, fermentation time 25
~40 days.
6. the preparation method of fermentation motherwort composition according to claim 4, which is characterized in that benefit is female in step (a)
The mesh number of grass is 200~300 mesh；
Preferably, it is 25~33 DEG C that yellow rice wine, which makes fermentation temperature when being fermented again with motherwort, koji, in step (a),
Fermentation time is 5~15 days.
7. the preparation method for the motherwort composition that ferments according to claim 4~6 any one, which is characterized in that step
Suddenly in (b), the soya bean of formula ratio is added in the water of remaining formula ratio, impregnate, cook, be cooled to room temperature again with formula ratio
Flour mixing is fermented；
Preferably, fermentation temperature when soya bean, water and flour are fermented in step (b) is 18~25 DEG C, fermentation time is 2~
3 days.
8. the preparation method for the motherwort composition that ferments according to claim 4~6 any one, which is characterized in that step
Suddenly in (b), the mesh number of motherwort is 200~300 mesh；
Preferably, it is 18~25 DEG C that soya bean, which makes fermentation temperature when being fermented again with motherwort, koji, in step (b),
Fermentation time is 5~15 days.
9. the preparation method for the motherwort composition that ferments according to claim 4~6 any one, which is characterized in that step
Suddenly dry after fermentation material one and fermentation material two are mixed in (c), obtain fermentation motherwort composition；
Preferably, drying temperature is 45~55 DEG C in step (c), and the dry moisture into fermentation motherwort composition is lower than
10%.
10. fermentation motherwort composition according to any one of claims 1 to 3 is any one using claim 4~9
Application of the preparation method fermentation motherwort composition obtained of fermentation motherwort composition described in Chinese medicine or feed.
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