CN109071436A - 一种吲哚生物碱类化合物及其制备方法和用途 - Google Patents

一种吲哚生物碱类化合物及其制备方法和用途 Download PDF

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CN109071436A
CN109071436A CN201680076350.3A CN201680076350A CN109071436A CN 109071436 A CN109071436 A CN 109071436A CN 201680076350 A CN201680076350 A CN 201680076350A CN 109071436 A CN109071436 A CN 109071436A
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compound
virus
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CN109071436B (zh
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李德海
于桂洪
朱天骄
顾谦群
车茜
王伟
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Ocean University of China
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种吲哚生物碱类化合物的制备方法和用途。本发明用采自南极普利兹湾深海海域的壳青霉PRB‑2(Penicillium crustosum PRB‑2)及化学合成的方法生产出结构新颖的吲哚生物碱类化合物。本发明的吲哚生物碱在体外和体内活性测试时均具有较好的抗甲型流感病毒活性，可作为新型滴鼻剂，鼻喷雾剂或口服制剂抗病毒药，用于预防和治疗甲型流感病毒感染。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201680076350.3A 2015-12-21 2016-12-20 一种吲哚生物碱类化合物及其制备方法和用途 Active CN109071436B (zh)

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CN2015109599234 2015-12-21
CN201510959923.4A CN106892854B (zh) 2015-12-21 2015-12-21 一种吲哚生物碱类化合物及其制备方法和用途
PCT/CN2016/111042 WO2017107897A1 (zh) 2015-12-21 2016-12-20 一种吲哚生物碱类化合物及其制备方法和用途

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Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
CN106892854B (zh) * 2015-12-21 2019-04-30 中国海洋大学 一种吲哚生物碱类化合物及其制备方法和用途
CN109206478A (zh) * 2017-07-09 2019-01-15 中国海洋大学 一种pks-nrps杂合的大环内酯类化合物及其制备方法和用途
CN111205196B (zh) * 2020-03-04 2021-04-02 中国科学院昆明植物研究所 一种苯酚类ab环结构化合物及其制备方法和应用
CN111995560B (zh) * 2020-08-26 2021-09-28 云南大学 一种单萜吲哚类化合物及其制备方法和应用
CN114507139B (zh) * 2022-02-23 2023-04-28 自然资源部第三海洋研究所 环丙烷类化合物及其制备方法与抗流感病毒的应用

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1119856A (zh) * 1993-02-24 1996-04-03 麦克公司 Hiv逆转录酶抑制剂
CN103937678A (zh) * 2014-01-24 2014-07-23 大连交通大学 一株海洋壳青霉、其衍生的喹啉酮类化合物及其制备和应用
CN104357505A (zh) * 2014-08-30 2015-02-18 云南民族大学 一种吲哚-四氢吡咯-2-酮类生物碱及其制备方法与应用
CN106892854B (zh) * 2015-12-21 2019-04-30 中国海洋大学 一种吲哚生物碱类化合物及其制备方法和用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1119856A (zh) * 1993-02-24 1996-04-03 麦克公司 Hiv逆转录酶抑制剂
CN103937678A (zh) * 2014-01-24 2014-07-23 大连交通大学 一株海洋壳青霉、其衍生的喹啉酮类化合物及其制备和应用
CN104357505A (zh) * 2014-08-30 2015-02-18 云南民族大学 一种吲哚-四氢吡咯-2-酮类生物碱及其制备方法与应用
CN106892854B (zh) * 2015-12-21 2019-04-30 中国海洋大学 一种吲哚生物碱类化合物及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ESTEVAO, MONICA S.等: "Indole based cyclooxygenase inhibitors: Synthesis, biological evaluation, docking and NMR screening", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *

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CN106892854B (zh) 2019-04-30
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CN109071436B (zh) 2020-10-27

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