CN1090489C - Anti-fatigue farmaceutical and its prepn. process - Google Patents

Abstract

The present invention relates to anti-fatigue medicine and a preparation method thereof. The medicine is prepared from stink-bug, longspur epimedium, medicinal evodia fruit and ginseng which are used as a formula and prepared by the steps of crude drug component extraction, mixture, granulation and encapsulation. The present invention has the advantages of reasonable and scientific formula, rapid and lasting medicine effect, novel dosage form, high bioavailability, and novel and unique preparation process and adapts to the change of industrial production technologies.

Description

A kind of antifatigue medicine and preparation technology thereof

The present invention relates to a kind of antifatigue medicine and preparation technology thereof, relate to a kind of formulatedly specifically, resisting fatigue is had the Chinese medicine medicine and the preparation technology of obvious dauer effect by plurality of Chinese.

At present, along with the progress of society, the development of competition mechanism, in high spirits go in the face of challenge be our each human needs.Yet the modern is but very easily tired, and people are inevitable otherwise disconnecting is subjected to the various pressure from work, society, family.Psychentonia very easily appears in people, and appetite descends, bradykinesia, and hypomnesis, attention such as can not concentrate at fatigue symptom, and soreness of the waist and knees is more arranged, and male sexuality is out of fashion, the indifferent direct family life that influences of libido.Be in the people in the tired vicious cycle for a long time, not only work efficiency descends, and quality of life reduces, and directly influences healthy.World Health Organization (WHO) classifies this situation as sub-health state, to strengthen the attention of people to it, to be beneficial to taking precautions against treatment.Though this state is not a disease, itself lying concealed the probability that disease produces.Resisting fatigue has become many medical workers' new research topic and direction in recent years.Have vital base and primordial QI consolidating, the China on the Chinese medicine basis of YIN and YANG balancing, vast research worker is seek assiduously equally.Yet existing anti-fatigue medicament is still undesirable, and often specific aim is poor, and effect is slow, and the cost height is adhered rigidly to ancient prescription, and dosage form is conservative.So, upgrade better anti-fatigue medicament and just remaining to be used.

The object of the present invention is to provide a kind ofly to be prepared from, a kind of antifatigue medicine and the preparation technology thereof of quick and durable antifatigue effect arranged, to overcome the deficiencies in the prior art by full Chinese medicine.

The present invention is the purport prescription according to " the kidney being the origin of congenital constitution " " liver is basis of the brown bear utmost point " with the liver and kidney tonifying.Aspongopus wherein, Herba Epimedii is the strong product of liver and kidney tonifying, the power of especially emerging sun; Fructus Evodiae, the power of getting its warming the interior recuperating depleted YANG, news are prompt to yang deficiency depressed power tired out is big.Modern study confirms: rutaecarpin that it includes and rutaecarpine can improve the anti-anoxia ability of body, and Radix Ginseng has strongly invigorating primordial QI, and kidney tonifying is supporing yang, excited maincenter, and resisting fatigue improves the physical activity ability.

The object of the present invention is achieved like this: it is by Aspongopus, Herba Epimedii, Fructus Evodiae, Radix Ginseng prescription, extraction through the crude drug composition, mix, granulate, the dress capsule forms, and it is characterized in that it is a kind of antifatigue medicine that the Chinese medicine extraction by following weight parts is prepared from: Aspongopus 100-280 part Herba Epimedii 300-840 part Fructus Evodiae 100-280 part Radix Ginseng 100-280 part.

With the Aspongopus of selecting, after Herba Epimedii, Fructus Evodiae, Radix Ginseng extract respectively and obtain effective ingredient, mixing together, with the molten seasoning of freezing of nanocapsule, with medicine and B-cyclodextrin, after 1: 1 molecular proportion dissolving, lyophilization, the dress capsule can be prepared a kind of antifatigue medicine and have another name called " Xie Ya " nanocapsule.

A kind of preparation technology of antifatigue medicine is characterized in that by following method preparation:

1. take by weighing Aspongopus, pulverize, cross 20 mesh sieves, add concentrated hydrochloric acid to full medicine submergence, make it convert Aspongopus acid to, filter, remove slag, acid solution adds qdx acetone merceration, filters, discard insoluble matter, reclaim most of acetone, grease, placed 24 hours, a large amount of precipitates are arranged, filter, go filtrate, precipitate gets the plain crude product of Aspongopus with petroleum ether, dehydrated alcohol (1: 1) washing, 10 times of amounts of reuse acetone recrystallization, filter, crystallization with petroleum ether, dehydrated alcohol (1: 1) washing, gets the plain pure product of Aspongopus, standby

2. take by weighing Herba Epimedii, pulverize, cross 20 mesh sieves, after the water logging one hour, decocting in water fries in shallow oil twice, each one hour, filter, merging filtrate is concentrated into 1/5 of original volume, add 95% ethanol of concentrated solution triplication, leave standstill, go precipitation, get ethanol extract, reclaim ethanol, become rare pure extractum, the amount of doubling dichloromethane extraction five times, when shallow, reuse is equivalent to the long-pending chloroform of rare pure extractum monoploid to the extract color, methanol (5: 1) extraction, use the ethyl acetate extraction five times of suitable one times of water gaging layer at last, acetic acid ethyl acetate extract is recycled to 1/5 amount of original volume, leave standstill, filter, get yellow powder, reuse 60% ethyl alcohol recrystallization gets the Herba Epimedii glycoside for several times, standby

3. take by weighing Fructus Evodiae, pulverize, cross 20 mesh sieves, the 95% ethanol liquid that contains 1%HCI with 3 times of amounts flooded 12 hours, filtered, and acid alcohol liquid is stand-by, medicinal residues were measured 95% alcohol reflux 2 hours with 2 times, and 6 times repeatedly, merging filtrate, pure liquid and acid alcohol liquid are merged, add strong aqua ammonia and transfer to pH6,60 ℃ of drying under reduced pressure, get the yellowish-brown dry product, broken 100 mesh sieves of crossing, standby

4. take by weighing commercially available Radix Ginseng coarse powder, pulverize, cross 20 mesh sieves, methanol with 2 times of volumes soaks, heating extraction, and extracting solution concentrates the back and places, in concentrated solution, add an amount of ether, can quicken precipitation and separate out, precipitation is dissolved in 95% ethanol, adds 1/3 ether, Saponin is separated out, filter, triplicate must be than the genuine soap glycoside

5. with above 1. 2. 3. 4. extracts from crude drugs mix homogeneously, with the molten seasoning of freezing of nanocapsule, with medicine and B-cyclodextrin, after dissolving by 1: 1 molecular proportion, lyophilization encapsulatedly promptly gets a kind of antifatigue medicine.

The present invention compared with prior art, its reasonable recipe, science, drug effect fast, lasting, the dosage form novelty, the bioavailability height, preparation technology is novel unique, is adapted to commercial production.

Further specify the present invention below in conjunction with embodiment

Raw material of the present invention can be made up of above-mentioned 4 kinds of crude drug effective ingredient, thereby performance is quicker, more effective, more persistent antifatigue effect.

1. take by weighing 100 gram Aspongopuss, pulverize, cross 20 mesh sieves, add concentrated hydrochloric acid to full medicine submergence, make it convert Aspongopus acid to, filter, remove slag, acid solution adds qdx acetone merceration, filters, discard insoluble matter, reclaim most of acetone, grease, placed 24 hours, a large amount of precipitates are arranged, filter, go filtrate, precipitate gets the plain crude product of Aspongopus with petroleum ether, dehydrated alcohol (1: 1) washing, 10 times of amounts of reuse acetone recrystallization, filter, crystallization with petroleum ether, dehydrated alcohol (1: 1) washing, gets the plain pure product of Aspongopus, standby

2. take by weighing 300 gram Herba Epimedii, pulverize, cross 20 mesh sieves, water logging is after one hour, and decocting in water fries in shallow oil twice, and each one hour, filter, merging filtrate is concentrated into 1/5 of original volume.Add 95% ethanol of concentrated solution triplication, leave standstill, go precipitation, get ethanol extract, reclaim ethanol, become rare pure extractum, the amount of doubling dichloromethane extraction five times, when shallow, reuse is equivalent to the long-pending chloroform of rare pure extractum monoploid, methanol (5: 1) extraction to the extract color.Use the ethyl acetate extraction five times of suitable one times of water gaging layer at last.Acetic acid ethyl acetate extract is recycled to 1/5 of original volume measures, leave standstill, filter, get yellow powder, reuse 60% ethyl alcohol recrystallization gets the Herba Epimedii glycoside for several times, and is standby,

3. take by weighing 100 gram Fructus Evodiaes, pulverize, cross 20 mesh sieves, the 95% ethanol liquid that contains 1%HCI with 3 times of amounts flooded 12 hours, filtered, and acid alcohol liquid is stand-by, medicinal residues were measured 95% alcohol reflux 2 hours with 2 times, and 6 times repeatedly, merging filtrate, pure liquid and acid alcohol liquid are merged, add strong aqua ammonia and transfer to pH6,60 ℃ of drying under reduced pressure, get the yellowish-brown dry product, broken 100 mesh sieves of crossing, standby

4. take by weighing the commercially available Radix Ginseng coarse powder of 100 grams, pulverize, cross 20 mesh sieves, methanol with 2 times of volumes soaks, heating extraction, and extracting solution concentrates the back and places, in concentrated solution, add an amount of ether, can quicken precipitation and separate out, precipitation is dissolved in 95% ethanol, adds 1/3 ether, Saponin is separated out, filter, triplicate must be than the genuine soap glycoside

5. with above 1. 2. 3. 4. extracts from crude drugs mix homogeneously, with the molten seasoning of freezing of nanocapsule, with medicine and B-cyclodextrin, after dissolving by 1: 1 molecular proportion, lyophilization encapsulatedly promptly gets a kind of antifatigue medicine.

Claims (2)

1, a kind of antifatigue medicine, it is by Aspongopus, Herba Epimedii, Fructus Evodiae, Radix Ginseng prescription, extraction through the crude drug composition, mix, granulate, the dress capsule forms, and it is characterized in that it is a kind of antifatigue medicine Aspongopus 100-280 part Herba Epimedii 300-840 part Fructus Evodiae 100-280 part Radix Ginseng 100-280 part that the Chinese medicine extraction by following weight parts is prepared from.

2, a kind of preparation technology of antifatigue medicine is characterized in that by following method preparation:

1. take by weighing an amount of Aspongopus, pulverize, cross 20 mesh sieves, add concentrated hydrochloric acid to full medicine submergence, make it convert Aspongopus acid to, filter, remove slag, acid solution adds qdx acetone merceration, filters, discard insoluble matter, reclaim most of acetone, grease, placed 24 hours, a large amount of precipitates are arranged, filter, go filtrate, precipitate gets the plain crude product of Aspongopus with petroleum ether, dehydrated alcohol washing in 1: 1,10 times of amounts of reuse acetone recrystallization, filter, crystallization with petroleum ether, dehydrated alcohol washing in 1: 1, gets the plain pure product of Aspongopus, standby

2. take by weighing an amount of Herba Epimedii, pulverize, cross 20 mesh sieves, after the water logging one hour, decocting in water fries in shallow oil twice, each one hour, filter, merging filtrate is concentrated into 1/5 of original volume, add 95% ethanol of concentrated solution triplication, leave standstill, go precipitation, get ethanol extract, reclaim ethanol, become rare pure extractum, the amount of doubling dichloromethane extraction five times, when shallow, reuse is equivalent to the long-pending chloroform of rare pure extractum monoploid to the extract color, methanol extraction in 5: 1, use the ethyl acetate extraction five times of suitable one times of water gaging layer at last, acetic acid ethyl acetate extract is recycled to 1/5 amount of original volume, leave standstill, filter, get yellow powder, reuse 60% ethyl alcohol recrystallization gets the Herba Epimedii glycoside for several times, standby

3. take by weighing an amount of Fructus Evodiae, pulverize, cross 20 mesh sieves, the 95% ethanol liquid that contains 1%HCI with 3 times of amounts flooded 12 hours, filtered, and acid alcohol liquid is stand-by, medicinal residues were measured 95% alcohol reflux 2 hours with 2 times, and 6 times repeatedly, merging filtrate, pure liquid and acid alcohol liquid are merged, add strong aqua ammonia and transfer to pH6,60 ℃ of drying under reduced pressure, get the yellowish-brown dry product, broken 100 mesh sieves of crossing, standby

4. take by weighing an amount of commercially available Radix Ginseng coarse powder, pulverize, cross 20 mesh sieves, methanol with 2 times of volumes soaks, heating extraction, and extracting solution concentrates the back and places, in concentrated solution, add an amount of ether, can quicken precipitation and separate out, precipitation is dissolved in 95% ethanol, adds 1/3 ether, Saponin is separated out, filter, triplicate must be than the genuine soap glycoside

5. with above 1. 2. 3. 4. extracts from crude drugs mix homogeneously, with the molten seasoning of freezing of nanocapsule, with medicine and B-cyclodextrin, after dissolving by 1: 1 molecular proportion, lyophilization encapsulatedly promptly gets a kind of antifatigue medicine.