CN100391478C - Extracte of Aspongopus chinensis Dallas and Extraction method therefor medicinal use and preparn. thereof - Google Patents
Extracte of Aspongopus chinensis Dallas and Extraction method therefor medicinal use and preparn. thereof Download PDFInfo
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- CN100391478C CN100391478C CNB2004100106905A CN200410010690A CN100391478C CN 100391478 C CN100391478 C CN 100391478C CN B2004100106905 A CNB2004100106905 A CN B2004100106905A CN 200410010690 A CN200410010690 A CN 200410010690A CN 100391478 C CN100391478 C CN 100391478C
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Abstract
The present invention provides a stink bug extractive and an extraction method thereof. Simultaneously, the present invention also provides an application and a formulation of a medicine and a functional food with the stink bug extractive as the basic activity. The extraction method comprises the steps that after a proper amount of stink bug is crushed, 95% ethanol is added, and the mixture is boiled for 2 hours; the operation is repeated for 3 to 4 times; then, the mixture is boiled with 70% ethanol for 2 hours until the mixture is colorless; petroleum ether is added into the ethanol extractive for extraction to obtain a petroleum ether extractive and dregs; the dregs are extracted with ethyl acetate to obtain an ester extractive and dregs. The stink bug extractive of the present invention can be used for preparing substances for resisting fatigue and enhancing the immunity of a human body, and the stink bug extractive has the functions of resisting fatigue and enhancing the immunity of a human body.
Description
Technical field:
The invention provides a kind of Aspongopus extract and extracting method thereof, also providing simultaneously with this extract is the medical usage and the preparation of primary activity, belongs to effective ingredient in Chinese extracting method and purposes technical field.
Background technology:
Aspongopus (Aspongopus chinensis Dallas) is the dry Scorpio of Pentatomiddae insecticide, is put into one of QI regulating medicine in the Chinese herbal medicine.Effect with circulation of qi promoting, pain relieving, warming the kidney to activate YANG does not see that so far it has the report of resisting fatigue and enhancing human body immunity function.
Summary of the invention:
The invention provides a kind of Aspongopus extract and extracting method, be applicable to suitability for industrialized production.
The invention also discloses the medical usage and the preparation of Aspongopus extract.
Technical solution of the present invention is as follows: after getting an amount of Aspongopus fragmentation, ethanol with 70-95% concentration boils 2-3h, carry out 3-4 time repeatedly, boil 2-3h with 60-80% ethanol then, till colourless, the petroleum ether of getting ethanol extraction adding 100～300 parts by weight rocks 10-15min at normal temperatures and extracts, separately win ligroin extraction and ether sublayer material, ether sublayer material is added 100～300 parts by weight ethyl acetate rocks 10-15min at normal temperatures and extract, after obtain ester extract thick, sepia extractum sample.
Being characterized by of extract of the present invention:
The lipid material of thick, sepia extractum sample.
Press practice of pharmacy, extract of the present invention can be prepared into the medicine of various clinical pharmaceutical dosage form as resisting fatigue and enhancing human body immunity, said medicament is a said dosage form on any pharmaceutics.Wherein, oral formulations is selected from any in tablet, capsule, pill, granule, suspensoid, drop pill, the oral liquid.
Medicine of the present invention preferably contains the Aspongopus extract of 1%-99% and the excipient of 99%-1% (medicine that comprises other compatibility), preferably contains the Aspongopus extract of 60%-70% and the excipient of 40%-10% (comprising the medicine that other compatibility is used).
Adjuvant in the medicine of the present invention is meant conventional excipient, as solvent, disintegrating agent, correctives, antiseptic, coloring agent, binding agent etc.The medicine that other compatibility in the medicine of the present invention is used, the Aspongopus extract that refers to effective dose is certain medicine material, again compatibility other can allow the Chinese medicine or the chemical drugs that share.
Following pharmacological evaluation shows that extract of the present invention has pharmacologically actives such as resisting fatigue and enhancing human body immunity:
Healthy kunming mouse is (male, body weight 18-20g), be divided into 14 groups at random, every group 15, the 1st group for not irritating hello group, 2-4 irritates respectively and feeds 0.02%, 0.2% and 0.6% ethanol extraction 0.5ml, the 5-7 group is irritated respectively and is fed 0.02%, 0.2% and 0.6% ligroin extraction 0.5ml, the 8-10 group is irritated respectively and is fed 0.02%, the ethyl acetate extract 0.5ml of 0.2% and 0.6% 3 dosage, the 11-13 group is irritated respectively and is fed 0.02%, 0.2% and 0.6% the extract 0.5ml of ester lower floor, the 14th group for irritating hello Oviductus Ranae 0.5ml matched group, continuous irrigation carries out mice swimming with a load attached to the body test after feeding 30d, detects to observe its resisting fatigue effect and immune indexes.
Conclusion: compare significant difference with matched group (6.1min) with the ester extract group mice swimming with a load attached to the body time the longest (13.1min) that 0.2% dosage irritate to be fed, compare difference with matched group not remarkable and 0.2% ethanol extract and ester are carried thing and other processed group mice swimming with a load attached to the body time.And ester extract filling hello group thymus, spleen with 0.2% dosage are heavy, thymus index is compared significant difference (P＜0.05) with matched group, and therefore, extract of the present invention has the effect of resisting fatigue, enhancing human body immunity function.
Be suitable for disease: tired and body's immunity reduces.
Instructions of taking:
2-6mg/kg body weight oral dose, 200mg/ time, 1 time/day.
Good effect of the present invention is: the Aspongopus extract consumption is few, and resisting fatigue and enhance immunity action effect are good, and cost is low, have no side effect.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limit the present invention by any way, under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope that awaits the reply of the present invention.
Embodiment 1
After the fragmentation of 1kg Aspongopus, add 6kg95% ethanol and boil 2h, carry out 4 times repeatedly till colourless, 2h is boiled with 70% ethanol in the back, carries out repeatedly 6 times, obtains ethanol extraction 100g, add the 10kg petroleum ether, obtain ether extract 10g and ether sublayer material 32g, ether sublayer material reuse 5kg ethyl acetate extracted, after obtain ester and carry thing 10g.
Embodiment 2
After the fragmentation of 1kg Aspongopus, add 7kg95% ethanol and boil 2h, carry out 4 times repeatedly till colourless, 2h is boiled with 70% ethanol in the back, carries out repeatedly 6 times, obtains ethanolic extract 120g, add the 11kg petroleum ether, obtain ether extract 13g and ether sublayer material 40g, ether sublayer material reuse 5kg ethyl acetate extracted, after obtain ester and carry thing 12g.
Embodiment 3
It is dry broken that 1kg Aspongopus ester is carried thing, crosses 80 mesh sieves, mixes with 60g starch then, adds 10% hot starch slurry 350g and 8g magnesium stearate and make soft material, makes wet granular then, makes granulate after the drying, carries out tabletting with tablet machine.Every contains active ingredient amount 200mg.
Other project should meet 2000 editions tablet projects of Pharmacopoeia of People's Republic of China relevant requirements.
Embodiment 4
Get Aspongopus ester extract 1kg, medical starch 0.5kg, with 80% ethanol liquid wet granulation, granulate, dress 1# capsule, every 0.2g.
Other project should meet 2000 editions capsule projects of Pharmacopoeia of People's Republic of China relevant requirements.
Claims (2)
1. the extracting method of an Aspongopus extract, mainly may further comprise the steps: after getting an amount of Aspongopus fragmentation, add 95% ethanol and boil 2-3h, carry out 3-4 time repeatedly, boil 2-3h with 70% ethanol then, till colourless, getting ethanol extraction adding petroleum ether extracts, separately win ligroin extraction and ether sublayer material, ether sublayer material extracted with ethyl acetate, after obtain the ester extract.
2. the application of the Aspongopus extract of claim 1 preparation in preparation treatment resisting fatigue and enhancing human body immunity function medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100106905A CN100391478C (en) | 2004-02-18 | 2004-02-18 | Extracte of Aspongopus chinensis Dallas and Extraction method therefor medicinal use and preparn. thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100106905A CN100391478C (en) | 2004-02-18 | 2004-02-18 | Extracte of Aspongopus chinensis Dallas and Extraction method therefor medicinal use and preparn. thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559447A CN1559447A (en) | 2005-01-05 |
| CN100391478C true CN100391478C (en) | 2008-06-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100106905A Expired - Fee Related CN100391478C (en) | 2004-02-18 | 2004-02-18 | Extracte of Aspongopus chinensis Dallas and Extraction method therefor medicinal use and preparn. thereof |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293785B (en) * | 2011-08-29 | 2012-12-12 | 河南科技大学 | Method for extracting secondary metabolites of insects or arthropods |
| CN103564272B (en) * | 2013-11-15 | 2014-12-24 | 遵义医学院 | Method for improving discharge of defensive substances out of aspongopus |
| CN106511394B (en) * | 2016-11-08 | 2020-07-28 | 山西中医学院 | Application of aspongopus fatty oil extract |
| CN108741056A (en) * | 2018-06-08 | 2018-11-06 | 四川理工学院 | A kind of preparation method for climbing sandworm extract adjusting immune function |
| CN110522769A (en) * | 2019-07-15 | 2019-12-03 | 贵州大学 | The extracting method and its application of aspongopus crude extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277853A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Anti-fatigue farmaceutical and its prepn. process |
| CN1454626A (en) * | 2003-05-16 | 2003-11-12 | 张忠发 | Chinese herbal medicine for enhancing immunity |
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2004
- 2004-02-18 CN CNB2004100106905A patent/CN100391478C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1277853A (en) * | 2000-06-14 | 2000-12-27 | 邓开仲 | Anti-fatigue farmaceutical and its prepn. process |
| CN1454626A (en) * | 2003-05-16 | 2003-11-12 | 张忠发 | Chinese herbal medicine for enhancing immunity |
Non-Patent Citations (2)
| Title |
|---|
| 九香虫研究与应用概略. 和韵苹.中国民族民间医药杂志，第50期. 2001 |
| 九香虫研究与应用概略. 和韵苹.中国民族民间医药杂志，第50期. 2001 * |
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| CN1559447A (en) | 2005-01-05 |
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Granted publication date: 20080604 Termination date: 20130218 |