CN109045153A - One plant medicinal material extracting solution and preparation method thereof - Google Patents
One plant medicinal material extracting solution and preparation method thereof Download PDFInfo
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to plant medicinal material extracting solution and preparation method thereof, include the following steps: for vegetable drug dissection to be placed in the extraction element of extraction system, Extraction solvent is added, soak extraction obtains first extract；First extract filtering is placed in enrichment facility, heating distillation, condensation obtains condensate liquid；It is back to condensate liquid in extraction element, continues to carry out soak extraction to vegetable drug, obtain extracting solution；Carry out above-mentioned steps are persistently alternately repeated, extracting solution is collected, obtains vegetable drug extracting solution.The preparation process flow is relatively simple, greatly reduces preparation cost, and the content of effective ingredient greatly improves in the vegetable drug extracting solution being prepared, and can play better drug effect.
Description
Technical field
The present invention relates to pharmaceutical technology fields, are related to plant medicinal material extracting solution and preparation method thereof.
Background technique
The extracting method of currently used vegetable drug effective component has solvent extraction method, steam distillation and distillation
Method, solvent extraction method are more common a kind of.Extraction element used in conventional solvent extraction method includes extractor, concentration
Device and condenser etc., detailed process are usually that vegetable drug is put into extractor, and Extraction solvent is added, then impregnates heating,
Heating extraction after a certain period of time, will be extracted medical fluid and be released from liquid outlet, the dregs of a decoction are retained in extractor, are then mentioned for the second time
It takes, so carries out 2-5 extraction, extract to finish substantially until effective component and stop extracting again, collect under each step extracting solution entrance
One of enrichment process.The extracting method is complex, and process flow is cumbersome, and higher cost, production efficiency is low, and preparation process
In be easily destroyed effective component, keep vegetable drug extract drug effect obtained bad.
Girald daphne bark is the root skin and stem skin of Thymelaeceae daphne plant D.giraldii Nitsche, the function with dispelling wind and removing obstruction in the meridians, stasis-dispelling and pain-killing
Effect is usually used in alleviating the symptoms such as articular rheumatic pain.It is civil to be used to alleviate headache, toothache, rheumatic arthritis, traumatic injury, stomach
Bitterly, the symptoms such as pain in the hepatic region and bronchitis.There are many chemical components, such as Coumarins studies have shown that girald daphne bark contains for modern pharmacy
(dephnetin and daphnin etc.), Diterpenes (daphnetoxin, hydroxydaphnetoxin, daphnegiradicin, daphnegiradidin and D.giraldii Nitsche
C prime etc.), lignin (syringaresinol, pinoresinol, dihydro sesamin and lariciresinol etc.), flavonoids, Anthraquinones
And the chemical components such as sterols.Wherein, Coumarins ingredient has preferable analgesia, anti-inflammation and anti-adjuvant-induced arthritis
Effect can be widely used for alleviating and treating the diseases such as all kinds of pain, rheumatism atrophic arthritis, joint sprain contusion.Winter daphne
Element belongs to Coumarins ingredient, is the effective component in girald daphne bark's root skin and stem skin, has dispelling wind and eliminating dampness, the function of promoting blood circulation and stopping pain
Effect, it may have expansion coronary vasodilator increases coronary blood flow, reduces heart arteries and veins oxygen demand, improve myocardial metabolism, promotes heart function extensive
The effects of multiple.
CN100500207A discloses a kind of detoxicated girald daphne and preparation method thereof, is in a certain proportion of founder's snippings
In the raw materials such as skin, ginger, Radix Glycyrrhizae plus the water of 10~16 times of amounts decocts 1~3 time, 1~3 hour every time, filters, merging filtrate is dense
It is reduced to the clear cream that relative density is 1.2~1.3；Add 90~95% ethyl alcohol to make alcohol content to 50~70%, be sufficiently stirred, placed
Night discards precipitating, takes supernatant and recycles ethyl alcohol, is concentrated into the thick paste that relative density is 1.3 to obtain the final product.The invention provides simultaneously
Using compound external-use transdermal absorption formulation made of the detoxicated girald daphne, said preparation is to be added to promote transdermal suction in detoxicated girald daphne
The Chinese medicine and cutaneous permeable agent of receipts are prepared, and can effectively facilitate the rapid absorption of pharmacological component, reach efficient speed
The therapeutic effect of effect, the preparation method fail to effectively improve the content of pharmacological component dephnetin.
CN101856435B discloses the preparation method and content assaying method of a kind of Daphne giraldii Nitsche total coumarin extract, should
Preparation method includes: using girald daphne bark's medicinal material as raw material, and water and/or C1~C5 aqueous lower alcoholic solutions extract for solvent, is made
Medicinal extract；Medicinal extract is mixed with solid diluent, organic solvent is added and extracts, recycling design obtains solid extract, or
By medicinal extract plus aqueous suspension, organic solvent extraction is added, recycling design obtains solid extract；By solid extract plus aqueous suspension,
Using macroporous adsorption resin chromatography, Daphne giraldii Nitsche total coumarin extract is obtained.It is living that the preparation method can not effectively improve pharmacology
The content of property ingredient dephnetin.
CN1785314B discloses a kind of girald daphne bark or the purposes of its alcohol extracting thing, is used to prepare drug, which reduces
Low-density lipoprotein white level and the relevant disease for the treatment of or prevention.The method for preparing Zushi daphneol extract is also disclosed, including
Step: it is impregnated girald daphne bark's medicinal material 12-48 hours with the ethyl alcohol of dehydrated alcohol or 30-90%, preferably 24 hours, filter is obtained by filtration
Liquid.The preparation method can not equally improve the content of girald daphne bark's medicinal active ingredient in preparation.
Therefore, it develops and a kind of makes girald daphne bark's extracting solution that medicinal active ingredient significantly improves and preparation is simple
It is significantly.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a plant medicinal material extracting solution and its preparation
Method is particularly suitable for the extraction process of girald daphne bark's medicinal material, in order to achieve that object of the invention, the invention adopts the following technical scheme:
(I) vegetable drug dissection is placed in the extraction element of extraction system, Extraction solvent is added, soak extraction obtains
To first extract；
(II) first extract filtering is placed in enrichment facility, heating distillation, condensation obtains condensate liquid；
(III) it is back to condensate liquid in extraction element, continues to carry out soak extraction to vegetable drug, obtain extracting solution；
(IV) it is persistently alternately repeated and carries out step (II) and step (III), collect extracting solution, obtain vegetable drug extracting solution.
Easy for description, this specification will be persistently alternately repeated described in step (IV) carries out step (II) and step
(III) it is referred to as circulating reflux.
Preparation method provided by the invention, first by the heated evaporation of part first extract, then by steam condensing reflux to extract
In system, making the solvent into extraction system, lasting circulating reflux continues vegetable drug without containing the pure solvent of solute
By pure solvent soak extraction, is conducive to the dissolution of vegetable drug effective component, effectively improves extraction efficiency.When use system of the invention
When Preparation Method extracts girald daphne bark's medicinal material, the content of dephnetin in girald daphne bark's extracting solution can be made are as follows: press vegetable drug Mass Calculation, often
The dephnetin that 1g vegetable drug is prepared is not less than 0.4mg.
The preparation process flow is relatively simple, greatly reduces the preparation cost of girald daphne bark's extracting solution, and in preparation process
The extraction efficiency of dephnetin in girald daphne bark can be made to effectively improve.
The extraction system includes sequentially connected extraction element 2, enrichment facility 1 and condensing unit 3；The condensation dress
3 outlets are set also to connect with the top entry of extraction element 2.
The extraction system uses continuous circumfluence extraction technique, it is only necessary to and primary investment medicinal material and solvent can be extracted continuously,
It extracts medicinal material by pure hot solvent every time, reduces solvent usage, shorten extraction time, thus extraction efficiency is significantly
It improves.
The extraction element 2 is equipped with agitating device, for being stirred to vegetable drug.
Preferably, the agitating device includes motor 21, the agitating shaft being connected to motor 29 and is set on agitating shaft 29
Agitating paddle.
Preferably, at least two long agitating paddles 27 and at least two short agitating paddles 28 are provided on the agitating shaft 29.
Preferably, the long agitating paddle 27 and short agitating paddle 28 are staggered on the agitating shaft 29.
Preferably, 27 both ends of long agitating paddle and the inner wall contact position of the extraction element 2 are equipped with hairbrush 26.
Preferably, 29 bottom of agitating shaft is connected with propeller 210.
Long agitating paddle and short agitating paddle on agitating device are staggered, and the material in extraction element can be made sufficiently mixed
It closes, increases extraction efficiency；The hairbrush of long agitating paddle both ends setting can brush the material being adhered on extraction element inner wall, avoid
The waste of material increases extraction efficiency；The helical form agitating paddle of agitating device bottom, can material to extraction element bottom into
Row secondary agitation is allowed to uniformly mixed.
Preferably, current-limiting apparatus is set in the connecting pipe of enrichment facility 1 and extraction element 2, so that the extraction fills
The Extraction solvent liquid level set in 2 is persistently higher than vegetable drug.
Preferably, the current-limiting apparatus is valve 4 or peristaltic pump.
Preferably, the extraction element 2 is double-layer cavity structure.
Preferably, it is equipped with liquid distribution trough 23 in the extraction element 2, flows into extraction element 2 from condensing unit 3 for making
Condensation after steam is evenly dispersed wanders.
Preferably, insulating layer 25 is equipped on the outside of the extraction element 2.
Preferably, the insulating layer 25 is aeroge carpet veneer, mineral wool carpet veneer, glass chopped strand mat layer or rock wool board
Layer.
The insulating layer 25 that the double-layer cavity structure of extraction element 2 and outside are equipped with can keep the temperature extraction element,
Improve extraction efficiency.
Preferably, 2 bottom of extraction element is equipped with openable and closable slag-drip opening 212.
The end socket of extraction element 2 uses pyramidal structure, and after slag-drip opening 212 is opened, the dregs of a decoction are smooth from slag-drip opening because being self-possessed
Discharge is not easy to remain in the subsequent cleaning of end socket dead angle influence, solves the problems, such as that traditional extraction element deslagging is slow.
Preferably, 2 top of extraction element is equipped with feed inlet 24.
Preferably, 2 bottom of extraction element is equipped with sieve plate 211, just mentions described in enrichment facility 3 for filtering to enter
Liquid.
1 bottom of enrichment facility is equipped with discharge port.
Preferably, heating mantle 11 is coated on the outside of the enrichment facility 1.
Preferably, the condensing unit 3 is water cooled condenser.
Preferably, the condensing unit 3 is vertical shell-and-tube condenser, horizontal shell-and-tube cooler or bushing type condensation
Device.
Step (I) Extraction solvent is that the ethyl alcohol of 50-90% (such as 50%, 60%, 70%, 80%, 90% etc.) is molten
Liquid.
Preferably, the volume that step (I) described Extraction solvent uses is 5-10 times of vegetable drug quality, such as 5 times,
6 times, 7 times, 8 times, 9 times, 10 times etc., wherein the volume is calculated with L, and the quality is calculated with Kg.
The Extraction solvent only need a step be added, can circulating reflux use, the usage amount of solvent is greatly saved, and make
Extraction efficiency is obtained to significantly improve.
Preferably, it is stirred while step (I) described immersion.
Preferably, the lasting when a length of 6-10h of step (IV), such as 6h, 7h, 8h, 9h, 10h etc..
The present invention also provides a kind of vegetable drug extracting solutions of preparation method preparation as described above.
Preferably, the vegetable drug is girald daphne bark, the content of dephnetin in the vegetable drug extracting solution are as follows: press plant
Quality of medicinal material calculates, and the dephnetin that every 1g vegetable drug is prepared is not less than 0.4mg.
Compared with the existing technology, the invention has the following advantages:
Preparation method provided by the invention, first by the heated evaporation of part first extract, then by steam condensing reflux to extract
In system, make the solvent into extraction system without containing the pure solvent of solute, in extraction system, condensing unit, enrichment facility
Persistent loop reflux extracts vegetable drug in the closed loop cycle system of composition, and vegetable drug is made to continue to be soaked by pure solvent
Bubble is conducive to the dissolution of vegetable drug effective component, effectively improves extraction efficiency.When use preparation method of the invention extracts the founder (of a school of learning)
When anaesthetic material, the content of dephnetin in girald daphne bark's extracting solution can be made are as follows: press vegetable drug Mass Calculation, every 1g vegetable drug preparation
Obtained dephnetin is not less than 0.4mg.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of extraction system of the present invention；
Wherein, 1- enrichment facility；11- heating mantle；2- extraction element；21- motor；22- service hatch；23- liquid distribution trough；
24- feed inlet；25- insulating layer；26- hairbrush；27- long agitating paddle；The short agitating paddle of 28-；29- agitating shaft；210 propellers；
211- sieve plate；212- slag-drip opening；3- water cooled condenser；4- valve.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
Embodiment 1
The present embodiment provides a kind of girald daphne bark's extracting solution, preparation method is as follows:
It by girald daphne bark's medicinal material 10kg dissection, is put into extraction element 2 through feed inlet, concentration is added as the leaching of 75% ethyl alcohol
Bubble, is stirred simultaneously, and the volume (L) that ethyl alcohol uses is 8 times of girald daphne bark's quality of medicinal material (Kg), and circulating reflux 10h obtains the founder (of a school of learning)
Numb extracting solution；Make alcohol extract enter enrichment facility 1 by opening valve 4 in time in reflux course, is evaporated in enrichment facility 1
Solvent condensed by condensing unit 3 after enter extraction element 2, realize that circulating reflux is extracted, circulating reflux collects after continuing 6h
Extracting solution adds water to 10L.Using " the 20th WS of the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation3- B-3927-98 " as defined in contain
Quantity measuring method (for description simplicity and makes data comparativity, following embodiment, application examples and comparative example are all made of this law progress
Assay) content of dephnetin is 0.5mg/mL in Detection and Extraction liquid, after being converted by girald daphne bark's quality of medicinal material are as follows: every g founder (of a school of learning)
0.5mg dephnetin is prepared in anaesthetic material.
Embodiment 2
The present embodiment provides a kind of girald daphne bark's extracting solution, preparation method is as follows:
It by girald daphne bark's medicinal material 4kg dissection, is put into extraction element 2 through feed inlet, concentration is added and is impregnated for 90% ethyl alcohol,
It stirs simultaneously, the volume (L) that ethyl alcohol uses is 6 times of girald daphne bark's quality of medicinal material (Kg), and circulating reflux 10h obtains girald daphne bark and mentions
Take liquid；Alcohol extract is made to enter enrichment facility 1 by opening valve 4 in time in reflux course, what is evaporated in enrichment facility 1 is molten
Agent realizes that circulating reflux is extracted, circulating reflux collects extraction after continuing 6h by entering extraction element 2 after the condensation of condensing unit 3
Liquid adds water to 4L.The content of dephnetin is 0.45mg/mL in Detection and Extraction liquid, after the conversion of girald daphne bark's quality of medicinal material are as follows: every g
0.45mg dephnetin is prepared in girald daphne bark's medicinal material.
Embodiment 3
The present embodiment provides a kind of girald daphne bark's extracting solution, preparation method is as follows:
It by girald daphne bark's medicinal material 6kg dissection, is put into extraction element 2 through feed inlet, concentration is added and is impregnated for 50% ethyl alcohol,
It stirs simultaneously, the volume (L) that ethyl alcohol uses is 10 times of girald daphne bark's quality of medicinal material (Kg), and circulating reflux 10h obtains girald daphne bark
Extracting solution；Make alcohol extract enter enrichment facility 1 by opening valve 4 in time in reflux course, is evaporated in enrichment facility 1
Solvent enters extraction element 2 after condensing by condensing unit 3, realizes that circulating reflux is extracted, and circulating reflux continues to collect after 10h to mention
Liquid is taken, 6L is added water to.The content of dephnetin is 0.40mg/mL in Detection and Extraction liquid, after the conversion of girald daphne bark's quality of medicinal material are as follows: every
0.40mg dephnetin is prepared in g girald daphne bark's medicinal material.
Embodiment 4
The present embodiment provides a kind of Wikstroemia indica extracting solution, preparation method is as follows:
It by Wikstroemia indica (seedling medicine) root 2kg dissection, is put into extraction element 2 through feed inlet, addition concentration is 50% ethyl alcohol
It impregnates, stirs simultaneously, the volume (L) that ethyl alcohol uses is 10 times of brother king's (seedling medicine) root quality (Kg), and circulating reflux 10h is obtained
Brother king (seedling medicine) root extracting solution；Make alcohol extract enter enrichment facility 1 by opening valve 4 in time in reflux course, is concentrated
The solvent evaporated in device 1 enters extraction element 2 after condensing by condensing unit 3, realizes that circulating reflux is extracted, circulating reflux is held
Extracting solution is collected after continuous 10h, adds water to 2L.The content of daphnoretin is 0.93mg/mL in Detection and Extraction liquid, by brother king (seedling medicine)
After the conversion of root herb quality are as follows: 0.93mg daphnoretin is prepared in every g girald daphne bark medicinal material.
Application examples 1
The application example provides a kind of Daphne giraldii Nitsche injection liquid, on the basis of girald daphne bark's extracting solution that embodiment 1 is prepared
Further processing processing, the specific method is as follows:
Girald daphne bark's extracting solution that Example 1 is prepared, is concentrated into relative density 1.10-1.20, and ethyl alcohol is added to containing
Alcohol amount reaches 65%-85%, refrigerates, and filtration recycles ethyl alcohol, is concentrated into relative density 1.15-1.25, adding water to 10L, (water reaches
To 1 times of quality of medicinal material), it refrigerates, filtration, adjusts pH to 6.0-7.5 with 20-30% sodium hydroxide solution, active carbon is added, it is living
Property charcoal usage amount be the 0.1% of quality of medicinal material, stir 30min, filtration is filtered with 0.2 μm of aseptic filtration film, encapsulating, 100 DEG C
30min is heat-treated to get Daphne giraldii Nitsche injection liquid.
Comparative example 1
The present embodiment provides a kind of girald daphne bark's extracting solutions, and preparation method is difference from example 1 is that by the founder (of a school of learning)
Fiber crops carry out heating decoction with the ethanol solution of 6 times of amounts 70%, and not stir, other operations are consistent.Girald daphne bark obtained extracts
The content of dephnetin is 0.042mg/mL in liquid.
Comparative example 2
The present embodiment provides a kind of girald daphne bark's extracting solution, preparation method is difference from example 1 is that will circulation
Refluxing extraction replaces with leakage and extracts, other operations are consistent.The content of dephnetin is in girald daphne bark's extracting solution obtained
0.167mg/mL。
The Applicant declares that the present invention is explained by the above embodiments vegetable drug extracting solution and its preparation side of the invention
Method, but the present invention is not limited to the above embodiments, that is, does not mean that the present invention must rely on above-described embodiment and could implement.Institute
Belong to those skilled in the art it will be clearly understood that any improvement in the present invention, to the equivalence replacement of each raw material of product of the present invention
And addition, selection of concrete mode of auxiliary element etc., all of which fall within the scope of protection and disclosure of the present invention.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
Claims (10)
1. the preparation method of a plant medicinal material extracting solution, which comprises the steps of:
(I) vegetable drug dissection is placed in the extraction element of extraction system, Extraction solvent is added, soak extraction obtains just
Extract；
(II) first extract filtering is placed in enrichment facility, heating distillation, condensation obtains condensate liquid；
(III) it is back to condensate liquid in extraction element, continues to carry out soak extraction to vegetable drug, obtain extracting solution；
(IV) it is persistently alternately repeated and carries out step (II) and step (III), collect extracting solution, obtain vegetable drug extracting solution.
2. preparation method as described in claim 1, which is characterized in that the vegetable drug is girald daphne bark, the vegetable drug
The content of dephnetin in extracting solution are as follows: press vegetable drug Mass Calculation, the dephnetin that every 1g vegetable drug is prepared is not less than
0.4mg。
3. preparation method as described in claim 1, which is characterized in that the extraction system includes sequentially connected extraction element
(2), enrichment facility (1) and condensing unit (3)；Condensing unit (3) outlet also connects with the top entry of extraction element (2)
It connects.
4. preparation method as claimed in claim 3, which is characterized in that the extraction element (2) is equipped with agitating device.
5. preparation method as claimed in claim 4, which is characterized in that the agitating device includes that motor (21) and motor connect
The agitating shaft (29) connect and the agitating paddle being set on agitating shaft (29)；
Preferably, at least two long agitating paddles (27) and at least two short agitating paddles (28) are provided on the agitating shaft (29)；
Preferably, the long agitating paddle (27) and short agitating paddle (28) are staggered on the agitating shaft (29)；
Preferably, the inner wall contact position of long agitating paddle (27) both ends and the extraction element (2) is equipped with hairbrush (26)；
Preferably, agitating shaft (29) bottom is connected with propeller (210).
6. preparation method as claimed in claim 3, which is characterized in that in the connecting tube of enrichment facility (1) and extraction element (2)
Current-limiting apparatus is set on road；
Preferably, the current-limiting apparatus is valve (4) or peristaltic pump.
7. preparation method as claimed in claim 3, which is characterized in that the extraction element (2) is double-layer cavity structure；
Preferably, liquid distribution trough (23) are equipped in the extraction element (2)；
Preferably, insulating layer (25) are equipped on the outside of the extraction element (2)；
Preferably, the insulating layer (25) is aeroge carpet veneer, mineral wool carpet veneer, glass chopped strand mat layer or rock wool board layer；
Preferably, extraction element (2) bottom is equipped with openable and closable slag-drip opening (212)；
Preferably, the extraction element (2) top is equipped with feed inlet (24)；
Preferably, the extraction element (2) bottom is equipped with sieve plate (211).
8. preparation method as claimed in claim 3, which is characterized in that enrichment facility (1) bottom is equipped with discharge port；
Preferably, heating mantle (11) are coated on the outside of the enrichment facility (1)；
Preferably, the condensing unit (3) is water cooled condenser；
Preferably, the condensing unit (3) is vertical shell-and-tube condenser, horizontal shell-and-tube cooler or bushing type condensation
Device.
9. preparation method as described in claim 1, which is characterized in that step (I) Extraction solvent is the ethyl alcohol of 50-90%
Solution；
Preferably, the volume that step (I) described Extraction solvent uses is 5-10 times of vegetable drug quality, wherein the volume
It is calculated with L, the quality is calculated with Kg；
Preferably, it is stirred while step (I) described immersion；
Preferably, the lasting when a length of 6-10h of step (IV).
10. a kind of vegetable drug extracting solution of preparation method preparation as claimed in claims 1-9；
Preferably, the vegetable drug is girald daphne bark, the content of dephnetin in the vegetable drug extracting solution are as follows: press vegetable drug
Mass Calculation, the dephnetin that every 1g vegetable drug is prepared are not less than 0.4mg.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711206A (en) * | 2019-10-14 | 2020-01-21 | 江西世纪龙文生物医药科技有限公司 | Inclusion bear gall powder, preparation method and equipment |
| WO2021003676A1 (en) * | 2019-07-09 | 2021-01-14 | 李春华 | Natural medicine extractor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302615A (en) * | 2011-08-30 | 2012-01-04 | 中国人民解放军第四五一医院 | Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof |
| KR20120113924A (en) * | 2011-04-06 | 2012-10-16 | 한국생명공학연구원 | Composition comprising extract of daphne genkwa as active ingradient |
| CN205199037U (en) * | 2015-12-18 | 2016-05-04 | 南阳市环境保护局 | Enrichment facility is drawed in circulation |
-
2018
- 2018-11-02 CN CN201811302668.6A patent/CN109045153A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120113924A (en) * | 2011-04-06 | 2012-10-16 | 한국생명공학연구원 | Composition comprising extract of daphne genkwa as active ingradient |
| CN102302615A (en) * | 2011-08-30 | 2012-01-04 | 中国人民解放军第四五一医院 | Effective site group of daphne giraldii nitsche leaf, preparation method, medicinal composition and application thereof |
| CN205199037U (en) * | 2015-12-18 | 2016-05-04 | 南阳市环境保护局 | Enrichment facility is drawed in circulation |
Non-Patent Citations (1)
| Title |
|---|
| 张文: "浅谈祖师麻不同提取工艺的比较研究", 《中国民族民间医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021003676A1 (en) * | 2019-07-09 | 2021-01-14 | 李春华 | Natural medicine extractor |
| CN113905795A (en) * | 2019-07-09 | 2022-01-07 | 李春华 | Natural medicine extractor |
| CN110711206A (en) * | 2019-10-14 | 2020-01-21 | 江西世纪龙文生物医药科技有限公司 | Inclusion bear gall powder, preparation method and equipment |
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