CN110711206A - Inclusion bear gall powder, preparation method and equipment - Google Patents
Inclusion bear gall powder, preparation method and equipment Download PDFInfo
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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Abstract
The embodiment of the invention discloses inclusion bear gall powder which comprises the following raw materials in parts by weight: 8-10 parts of bear gall powder and 24-60 parts of beta-cyclodextrin. A method for preparing the inclusion bear gall powder is characterized by heating bear gall containing the bear gall powder and beta-cyclodextrin for dissolving, adding 95% ethanol to enable the alcohol content of the mixture to reach 20-40%, stirring for inclusion for 1 hour, and recovering the ethanol. Obtaining the bear gall powder inclusion liquid medicine, and freeze-drying the bear gall powder inclusion liquid medicine to obtain the bear gall inclusion powder. The utility model provides an equipment that is used for inclusion bear gall powder, equipment include steam generator, intermediate layer heating tank, condenser and agitator, wherein, the lateral wall of intermediate layer heating tank is equipped with the steam intermediate layer, the bottom of intermediate layer heating tank is equipped with the stirring rake, stirring rake drive shaft connection has the motor. The inclusion bear gall powder has the advantages of main functional indications, medical effects and drug effect components which are completely the same as those of the existing bear gall powder, but is not bitter, fishy, difficult to absorb moisture, stable in quality and the like.
Description
Technical Field
The embodiment of the invention relates to the technical field of traditional Chinese medicine preparation, in particular to inclusion bear gall powder, a preparation method of the inclusion bear gall powder and equipment for preparing the inclusion bear gall powder.
Background
The fel Ursi powder is dried product prepared from bile of black bear (Selenaretos Thibeta Cuver) or brown bear (Ursus aretos) of Ursidae. According to records of traditional Chinese medicine classics ' Shennong Ben Cao Lun ' (Shennong's herbal), ' Tang Ben Cao ' (Ben Cao gang mu); can be used for treating convulsion, conjunctival congestion, swelling and pain, and sore throat; the dosage is 0.3-1 g, and is mostly taken in pill and powder form, and proper amount is externally used, and the pill is ground or mixed with water to be applied to the affected part; meanwhile, the bear gall powder also has various pharmacological actions of reducing cholesterol of a human body, reducing hypertension and hyperlipidemia, dissolving biliary calculus and the like, can be taken for a long time, prevents diseases, and is beneficial to health.
The traditional Chinese medicine raw material bear gall powder sold in the market and the finished product medicine Chinese herbal piece bear gall powder have extremely bitter taste and fishy smell; is easy to absorb moisture. In order to avoid the exceeding of microorganisms in the bear gall powder, some enterprises adopt terminal cobalt 60 radiation to treat the bear gall powder, and the bear gall powder is not subjected to cobalt 60 residue detection and evaluation, so that the safety of medicine application is worried. Meanwhile, the bear gall powder needs to be stored away from light and in shade. When the bear gall powder is taken, the children and the old people have the side effects of difficult tolerance of fishy and bitter taste, inappropriately regurgitation, vomiting and the like.
Therefore, the bear gall powder in the prior art has extremely bitter taste and fishy smell, is easy to absorb moisture, and is difficult to control microorganisms, and although the microorganisms can reach the standard by adopting cobalt 60 radiation sterilization, the bear gall powder has medication risk, so that further improvement is urgently needed.
Disclosure of Invention
Therefore, the embodiment of the invention provides the inclusion bear gall powder and the preparation method thereof, which aim to solve the problems of fishy smell, bitter taste, easy moisture absorption and the like of the bear gall powder in the prior art.
In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:
the inclusion bear gall powder comprises the following raw materials in parts by weight: 8-10 parts of bear gall powder and 24-60 parts of beta-cyclodextrin.
Preferably, the inclusion bear gall powder comprises the following raw materials in parts by weight: 8.5-9.5 parts of bear gall powder and 25-59 parts of beta-cyclodextrin.
The embodiment of the invention also provides a method for preparing the inclusion bear gall powder, which comprises the steps of heating and dissolving bear gall containing the bear gall powder and beta-cyclodextrin, stirring and including to obtain the inclusion bear gall powder liquid medicine, and freeze-drying the inclusion bear gall powder liquid medicine to obtain the inclusion bear gall powder.
Preferably, the bear bile is thawed, sterilized, heated at 60-100 deg.C, boiled for 20-30min, and fine filtered.
Preferably, the stirring inclusion heating temperature is 85-100 ℃.
Preferably, the freeze-drying process is as follows: uniformly spreading the wrapped bear gall powder liquid medicine on a disc, and pre-freezing to ensure that the bear gall powder liquid medicine is below-40 ℃; continuously carrying out freeze drying at-45 to +50 ℃ to ensure that the water content of the inclusion bear gall powder is within 3 percent, thus obtaining the inclusion bear gall powder.
Preferably, in the stirring inclusion process, 95% ethanol is added into the mixture of bear bile containing bear bile powder and beta-cyclodextrin to enable the ethanol content of the mixture to reach 20-40%, stirring inclusion is carried out for 1 hour, and ethanol is recovered.
The embodiment of the invention also provides equipment for preparing the bear gall powder inclusion, which comprises a steam generator, an interlayer heating tank, a condenser and a stirrer, wherein a steam interlayer is arranged on the outer side wall of the interlayer heating tank, a steam trap and a drain valve are arranged at the bottom end of the steam interlayer, a stirring paddle is arranged at the bottom of the interlayer heating tank, a driving shaft of the stirring paddle is connected with a motor, the steam generator is connected with the steam interlayer through a pipeline, the upper part of the interlayer heating tank is connected with the condenser, and the part of the equipment, which is in direct contact with the medicine materials, is made of 316 stainless steel materials.
Preferably, the apparatus further comprises an ethanol recovery vessel connected to the condenser.
Preferably, the inlet and the outlet of the condenser are respectively connected with the interlayer heating tank.
The embodiment of the invention has the following advantages:
the inclusion bear gall powder has the advantages of main functional indications, medical effects and drug effect components which are completely the same as those of the existing bear gall powder, but is not bitter, fishy, difficult to absorb moisture, stable in quality and the like.
In addition, the microorganisms of the bear gall powder can reach the national standard without being shaded and stored in the shade; stable quality, convenient large-scale production, storage and transportation, convenient preservation for patients and direct oral administration. In the preparation process of the inclusion bear gall powder, the inclusion auxiliary materials are added: the beta-cyclodextrin is absorbed by human body and converted into nutrients such as glucose and the like required by human body, the adopted ethanol is completely recovered, all the used auxiliary materials are safe, the effective components of the bear gall powder are not changed, and the application is beneficial and harmless to users.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so that those skilled in the art can understand and read the present invention, and do not limit the conditions for implementing the present invention, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the functions and purposes of the present invention, should still fall within the scope of the present invention.
Fig. 1 is a schematic structural diagram of an apparatus for preparing inclusion bear gall powder, which is provided by the embodiment 1 of the invention;
in the figure: 100-sandwich heating tank; 110-steam sandwich; 111-a first pressure gauge; 112-a safety valve; 120-a motor; 130-stirring paddle; 140-a feed inlet; 150-a discharge port; 160-second pressure gauge; 170-temperature table; 200-a steam generator; 210-a steam control valve; 300-a condenser; 310-a reflux valve; 320-an exhaust duct; 321-an exhaust valve; 400-ethanol recovery vessel; a 410-ethanol recovery valve; 420-steam trap.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the examples of the present invention, all parts and amounts are by weight, and all raw and auxiliary materials are commercially available.
In the embodiment of the invention, the medicinal property of the inclusion bear gall powder belongs to traditional Chinese medicine decoction pieces, and the inclusion bear gall powder is not only a traditional Chinese medicine decoction piece directly taken orally, but also a good raw material traditional Chinese medicine decoction piece of a simple formula preparation of the bear gall powder, a compound traditional Chinese medicine and a Chinese and western medicine preparation formula.
Example 1
100kg of frozen bear bile containing 8kg of bear bile powder is detected, and the bear bile is thawed by heating, boiled at 100 deg.C for 30min, and fine-filtered to remove impurities in the bear bile.
Transferring the finely filtered bear bile into a sandwich heating tank, controlling the temperature of the bile at 60-70 ℃, adding 24kg of beta-cyclodextrin, adding a proper amount of water, heating and stirring to completely dissolve the beta-cyclodextrin, adding 20kg of 95% medicinal ethanol, stirring, refluxing and clathrating for 60min, and recovering ethanol to obtain a medicinal liquor containing bear bile powder; discharging the inclusion bear gall powder liquid medicine, uniformly spreading the liquid medicine on a plate, placing the spread bear gall powder liquid medicine in a material chamber of a freeze dryer, carrying out freeze drying, setting a freeze drying section of 8-10 and a freeze drying curve, pre-freezing for about 4 hours to ensure that the temperature of the liquid medicine reaches below minus 45 ℃, then controlling the temperature to be minus 45 ℃ to plus 50 ℃, carrying out freeze drying for about 24 hours, drying until the moisture content of the inclusion bear gall powder is lower than 3%, collecting the inclusion bear gall powder, sieving by a sieve of 20-40 meshes, inspecting, and subpackaging according to specifications to obtain the finished inclusion bear gall powder.
Example 2
Heating and thawing frozen and stored bear bile containing 8kg of bear bile powder, boiling at 100 deg.C for 30min, and fine filtering to remove impurities.
Transferring the finely filtered bear bile into a sandwich heating tank, controlling the temperature of the bear bile at 80-90 ℃, adding 40kg of beta-cyclodextrin, adding a proper amount of water, heating and stirring to completely dissolve the beta-cyclodextrin, adding 30kg of 95% medicinal ethanol, stirring, refluxing and clathrating for 60min, and recovering the ethanol to obtain a medicinal liquor containing bear bile powder; discharging the inclusion bear gall powder liquid medicine, uniformly spreading the liquid medicine on a plate, placing the plate-spread bear gall powder liquid medicine in a material chamber of a freeze dryer, carrying out freeze drying, setting a freeze-drying section of 8-10 and a freeze-drying curve, pre-freezing for about 4 hours to ensure that the temperature of the liquid medicine reaches below minus 45 ℃, then controlling the temperature to be minus 45 ℃ to plus 50 ℃, carrying out freeze drying for about 24 hours, drying until the moisture content of the inclusion bear gall powder is lower than 3%, collecting the inclusion bear gall powder, sieving by a sieve of 20-40 meshes, inspecting, and subpackaging according to specifications to obtain the finished inclusion bear gall powder.
Example 3
Heating and thawing frozen and stored bear bile containing 8kg of bear bile powder, boiling at 100 deg.C for 30min, and fine filtering to remove impurities.
Transferring the finely filtered bear bile into a sandwich heating tank, controlling the temperature of the sandwich heating tank at 80-90 ℃, adding 48kg of beta-cyclodextrin, adding a proper amount of water, heating and stirring to completely dissolve the beta-cyclodextrin, adding 30kg of 95% medicinal ethanol, stirring, refluxing and clathrating for 60min, and recovering the ethanol to obtain a medicinal liquor containing bear bile powder; discharging the inclusion bear gall powder liquid medicine, uniformly spreading the liquid medicine on a plate, placing the plate-spread bear gall powder liquid medicine in a material chamber of a freeze dryer, carrying out freeze drying, setting a freeze drying section of 8-10 and a freeze drying curve, pre-freezing for 4 hours to ensure that the temperature of the liquid medicine reaches below minus 45 ℃, then controlling the temperature to be minus 45 ℃ to plus 50 ℃, carrying out freeze drying for about 24 hours, drying until the moisture content of the inclusion bear gall powder is lower than 3%, collecting the inclusion bear gall powder, sieving by a sieve of 20-40 meshes, inspecting, and subpackaging according to specifications to obtain the finished inclusion bear gall powder.
In the embodiment of the invention, the finished product of the inclusion bear gall powder is subjected to total mixing according to batches, is inspected to be qualified, is internally packaged in a clean area and is subpackaged into finished product specifications of 1.0-2.0 g/bottle or bag, and then the direct oral Chinese medicinal decoction pieces are subjected to inclusion bear gall powder; or subpackaging into finished product specifications: 1000 g/barrel or bag to obtain the bear gall powder wrapped by the raw materials of the traditional Chinese medicine decoction pieces.
Example 4
As shown in fig. 1, the embodiment of the present invention further provides an apparatus for preparing inclusion bear gall powder, which includes a steam generator 200, an interlayer heating tank 100, a condenser 300 and a stirrer 120 and 130, wherein the outer sidewall of the interlayer heating tank 100 is provided with a steam interlayer 110, and the portion of the apparatus for preparing inclusion bear gall powder, which is in direct contact with the medicine material, is made of 316 stainless steel. The bottom of intermediate layer heating tank 100 is equipped with stirring rake 130, and stirring rake 130 drive shaft is connected with motor 120, and motor 120 drive stirring rake 130 operates, realizes the stirring to the feed liquid in the intermediate layer heating tank 100, and steam generator 200 is connected with steam intermediate layer 110, and the steam that steam generator 200 produced is carried steam intermediate layer 110 through the connecting tube in, heats intermediate layer heating tank 100, provides the temperature for the raw materials in the intermediate layer heating tank 100. The upper portion of the interlayer heating tank 100 is connected with a condenser 300, the condenser 300 is a shell and tube condenser, a cooling pipeline of the condenser 300 is provided with a water inlet pipe and a water outlet pipe, the condenser 300 enters cooling water through the water inlet pipe to cool feed liquid inside the condenser 300, and the cooling water after heat exchange flows out through the water outlet pipe.
Wherein, the upper part of the interlayer heating tank 100 is provided with a feed inlet 140, and the bear bile and beta-cyclodextrin to be treated are added through the feed inlet 140; the bottom of the interlayer heating tank 100 is provided with a discharge port 150, the interlayer heating tank 100 is stirred for inclusion, and the medicine materials subjected to stirring inclusion treatment are led out through the discharge port 150.
The equipment for clathrating the bear gall powder further comprises an ethanol recovery container 400, the ethanol recovery container 400 is connected with the condenser 300, an ethanol recovery valve 410 is arranged on a pipeline connecting the ethanol recovery container 400 with the condenser 300, medicinal ethanol added into the interlayer heating tank 100 forms ethanol steam under the heating condition, the ethanol steam is condensed by the condenser 300 to form liquid ethanol, the ethanol recovery valve 410 is opened, and the liquid ethanol can enter the ethanol recovery container 400 through the pipeline. Because the inlet and the outlet of the condensation recoverer are respectively connected with the interlayer heating tank 100, the liquid ethanol can also flow back into the interlayer heating tank 100 through the connecting pipeline and continuously participate in the backflow.
Preferably, the condenser adopts a shell and tube type condensation. A return valve 310 is provided on a pipe connecting an outlet of the condenser 300 and the sandwiched heating tank 100, and when the ethanol to be condensed further enters the sandwiched heating tank 100 to be refluxed, the return valve 310 needs to be opened and the ethanol recovery valve 410 needs to be closed, so that the ethanol is refluxed into the sandwiched heating tank 100.
The interlayer heating tank 100 of the embodiment of the invention is provided with the first pressure gauge 111 and the temperature gauge 170, the pressure of the steam interlayer 110 is detected through the first pressure gauge 111, and the temperature of the liquid medicine in the interlayer heating tank 100 is detected through the temperature gauge 170. Similarly, a safety valve 112 and a second pressure gauge 160 are arranged on the steam interlayer 110, the pressure in the interlayer heating tank 100 is detected through the second pressure gauge 160, steam is supplemented into the steam interlayer 110 according to the change of the pressure, a steam trap 420 and a drain valve are arranged at the bottom end of the steam interlayer 110, and condensed water in the interlayer is drained from the steam trap and the drain valve 420.
An exhaust pipe 320 is provided on a pipe connecting an inlet of the condenser 300 and the sandwiched heating tank 100, and an exhaust valve 321 is provided on the exhaust pipe 320. When it is necessary to exhaust the gas in the interlayer heating tank 100, the exhaust valve 321 may be opened.
A steam control valve 210 is provided on a connection pipe between the steam generator 200 and the sandwich heating tank 100, and when the sandwich heating tank 100 needs to be heated, the steam control valve 210 is opened to transmit steam generated in the steam generator 200 into the steam sandwich 110.
Preferably, a support frame is further installed at the bottom of the interlayer heating tank 100 to support the entire interlayer heating tank 100.
The part of the equipment in the embodiment of the invention, which is directly contacted with the medicine, is made of 316 stainless steel, and the equipment for including the bear gall powder is very suitable for the process of preparing the inclusion bear gall powder, is simple and convenient to operate and is easy to clean.
Test example 1
The inclusion bear gall powder prepared in the embodiments 1 to 3 of the invention is compared with the bear gall powder produced by a commercial manufacturer; the inclusion bear gall powder and the commercial bear gall powder are subjected to a comparison experiment of taste and moisture absorption of the inclusion bear gall powder and the commercial bear gall powder which are exposed in the air by 30 persons. 1. Bitter taste sense: extremely bitter taste for 9-10 minutes; is bitter 7 to 8; not bitter less than 6 points; 2. fishy smell sense: 9-10 minutes of extremely fishy smell; 7-8 minutes more than the fishy smell; the fishy smell is less than 6 minutes; 3. and (4) storing time.
TABLE 1
As can be seen from Table 1, the enclosed bear gall powder prepared by the embodiment of the invention is not bitter and fishy, and is not easy to absorb moisture and the storage time is prolonged.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. The inclusion bear gall powder is characterized by comprising the following raw materials in parts by weight: 8-10 parts of bear gall powder and 24-60 parts of beta-cyclodextrin.
2. The inclusion bear gall powder as claimed in claim 1,
the inclusion bear gall powder comprises the following raw materials in parts by weight: 8.5-9.5 parts of bear gall powder and 25-59 parts of beta-cyclodextrin.
3. The preparation method of the inclusion bear gall powder of claim 1, which is characterized by comprising the steps of dissolving bear gall containing bear gall powder and beta-cyclodextrin by heating, stirring for inclusion to obtain an inclusion bear gall powder liquid medicine, and freeze-drying the inclusion bear gall powder liquid medicine to obtain the inclusion bear gall powder.
4. The method of claim 3,
thawing bear bile, sterilizing, heating at 60-100 deg.C, boiling for 20-30min, and fine filtering.
5. The method of claim 3,
the heating temperature of the stirring inclusion is 85-100 ℃.
6. The method of claim 3,
the freeze drying process comprises the following steps: uniformly spreading the wrapped bear gall powder liquid medicine on a disc, and pre-freezing to ensure that the bear gall powder liquid medicine is below-40 ℃; continuously carrying out freeze drying at-45 to +50 ℃ to ensure that the water content of the inclusion bear gall powder is within 3 percent, thus obtaining the inclusion bear gall powder.
7. The method of claim 3,
in the stirring and clathrating process, 95% ethanol is added into the mixture of bear bile containing bear bile powder and beta-cyclodextrin to make the alcohol content of the mixture reach 20-40%, stirring and clathrating for 1 hr, and recovering ethanol.
8. The device for preparing the bear gall powder inclusion compound device of claim 1, which comprises a steam generator, an interlayer heating tank, a condenser and a stirrer, wherein a steam interlayer is arranged on the outer side wall of the interlayer heating tank, a steam trap and a drain valve are arranged at the bottom end of the steam interlayer, a stirring paddle is arranged at the bottom of the interlayer heating tank, a motor is connected with a driving shaft of the stirring paddle, the steam generator is connected with the steam interlayer through a pipeline, the upper portion of the interlayer heating tank is connected with the condenser, and the portion of the device, which is in direct contact with the medicinal materials, is made of 316 stainless steel materials.
9. The apparatus of claim 8,
the equipment also comprises an ethanol recovery container, and the ethanol recovery container is connected with the condenser.
10. The apparatus of claim 8,
and the inlet and the outlet of the condenser are respectively connected with the interlayer heating tank.
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| CN201910973919.1A CN110711206A (en) | 2019-10-14 | 2019-10-14 | Inclusion bear gall powder, preparation method and equipment |
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| CN201910973919.1A CN110711206A (en) | 2019-10-14 | 2019-10-14 | Inclusion bear gall powder, preparation method and equipment |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
| CN113499308A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall oral liquid and preparation method and application thereof |
| CN114098009A (en) * | 2021-11-22 | 2022-03-01 | 常德云港生物科技有限公司 | Preparation facilities of pig gall powder after pig gall draws bilirubin |
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| CN101336934A (en) * | 2008-08-08 | 2009-01-07 | 福建建东药业有限公司 | Bear bile buccal tablet and preparation process thereof |
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| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
| CN113499308A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall oral liquid and preparation method and application thereof |
| CN114098009A (en) * | 2021-11-22 | 2022-03-01 | 常德云港生物科技有限公司 | Preparation facilities of pig gall powder after pig gall draws bilirubin |
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