CN109045066A - 一种复合碘伏消毒液及其制备方法 - Google Patents

一种复合碘伏消毒液及其制备方法 Download PDF

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CN109045066A
CN109045066A CN201811263777.1A CN201811263777A CN109045066A CN 109045066 A CN109045066 A CN 109045066A CN 201811263777 A CN201811263777 A CN 201811263777A CN 109045066 A CN109045066 A CN 109045066A
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刘秀文
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Abstract

本发明是一种复合碘伏消毒液及其制备方法，原料按重量份数如下：碘0.5‑1份，碘化钾0.5‑1份，聚乙烯吡咯烷酮6‑7份，烷基酚聚氧乙烯醚2‑3份，壳聚糖0.1‑0.5份，茶树油0.5‑1份，棕榈油0.1‑1份，失水山梨醇单硬脂酸酯0.1‑1份，异丙醇0.1‑1份，去离子水110‑125份。本发明在密闭不加热条件下进行，有效碘成分损失小，无废气、废液排放；工艺及操作简单，劳动强度小，自动化程度高，参数容易控制；可以有效提高配方含量及生产效率，效果非常明显，在制备工艺上有较大的发展潜力。

Description

一种复合碘伏消毒液及其制备方法
技术领域
本发明涉及的药物开发技术、涉及对传统碘伏制剂生产工艺的改进，通过新工艺改善了传统碘伏生产过程的不良特性，降低生产成本、增项了碘伏的消毒效果以及增加了辅助功效。
背景技术
碘伏，在消毒行业中归类为含碘制剂，含碘制剂定义为以碘为主要杀菌成分的消毒剂，主要包括：碘酊、碘伏。碘伏定义为，碘与聚醇醚和聚乙烯吡咯烷酮类表面活性剂形成的络合物。
碘，本品为灰黑色或蓝黑色、有金属光泽的片状结晶或块状物，质重、脆、有特臭，在常温中能挥发。碘在乙醇、乙醚或二硫化碳中易溶，在三氯甲烷中溶解，在四氯化碳中略溶，在水中几乎不溶，在碘化钾或碘化钠的水溶液中溶解。是消毒防腐药。
碘化钾，为无色结晶或白色结晶性粉末，无臭，微有引湿性。碘化钾在水中极易溶解，在乙醇中溶解。是补碘药。
聚醇醚，聚醇醚是一类物质，此类物质为非离子表面活性剂，为粘合剂和助溶剂等。
聚维酮，本品为白色至乳白色粉末，无臭或稍有特臭,无味，具引湿性。聚维酮在水、乙醇、异丙醇或三氯甲烷中溶解，在丙酮或乙醚中不溶。药用辅料，黏合剂和助溶剂等。
根据传统碘伏主要原料的性质特征可以看出，目前市场上主流碘伏产品主要为醚碘和酮碘，其两种产品的生产工艺主要缺点为：醚碘生产工艺由于其使用原料的特性，缺点在于产品分散性不强、液体粘稠不宜涂抹均匀、产品稳定性差、刺激性强、黄染严重等；酮碘生产工艺由于其使用原料特性，缺点在于生产需通过络合技术，生产周期长、工艺复杂、所需设备多、易产生烟尘、投入人工多等。
发明内容
本发明目的是针对现有技术存在的不足，提供一种简单易行、络合效果更好的碘伏制备技术。
为实现本发明的目的，采用的技术方案是：一种碘伏消毒液，原料按重量份数如下：碘0.5-1份，碘化钾0.5-1份，聚乙烯吡咯烷酮6-7份，烷基酚聚氧乙烯醚2-3份，壳聚糖0.1-0.5份，茶树油0.5-1份，棕榈油0.1-1份，失水山梨醇单硬脂酸酯0.1-1份，异丙醇0.1-1份，去离子水110-125份。
本发明具有以下优点：
本发明涉及一种碘伏的制备方法，其特征在于所用设备简单且少，设备故障容易排除，设备可重复循环利用，减少设备投资，在密闭不加热条件下进行，有效碘成分损失小，无废气、废液排放；工艺及操作简单，劳动强度小，自动化程度高，参数容易控制；所有原料、溶液都可重复循环使用，减少原料成本，无废液、废渣排放，无环境污染。本发明的方法有效节省设备、原料、试剂及成本，无三废排放，节能、减排、环保、低成本，可以有效提高配方含量及生产效率，效果非常明显，在制备工艺上有较大的发展潜力。
在原有传统碘伏配方基础上，加入了壳聚糖、茶树油、棕榈油、失水山梨醇单硬脂酸酯、异丙醇、烷基酚聚氧乙烯醚进行配置，配置方法、性质表征及效果测试方法均包括在本发明中。
具体实施方式
下面结合实施例对本发明进一步说明。一种碘伏消毒液，原料按重量份数如下：
碘0.5-1份，碘化钾0.5-1份，聚乙烯吡咯烷酮6-7份，烷基酚聚氧乙烯醚2-3份，壳聚糖0.1-0.5份，茶树油0.5-1份，棕榈油0.1-1份，失水山梨醇单硬脂酸酯0.1-1份，异丙醇0.1-1份，去离子水110-125份。
碘0.91份，碘化钾0.91份，聚乙烯吡咯烷酮6.15份，烷基酚聚氧乙烯醚2.7份，壳聚糖0.35份，茶树油0.6份，棕榈油0.4份，失水山梨醇单硬脂酸酯0.15份，异丙醇0.1份，去离子水125份。
采用的制备方法是：
1)、将碘、碘化钾均匀搅拌3-5分钟，将混合物加入烷基酚聚氧乙烯醚中，再均匀搅拌2小时，制得混合物A；
2)、将失水山梨醇单硬脂酸酯、异丙醇加入去离子水中搅拌溶解，加入聚乙烯吡咯烷酮继续搅拌均匀，制成溶液B；
3)、将A和B混合搅拌0.5-1小时后一起密闭遮光放置24小时后再均匀搅拌1小时得C；
4)、在溶液C中加入壳聚糖、茶树油、棕榈油，搅拌0.5-1小时，制得碘伏消毒液。
实施例
本发明提供的一种碘伏消毒液，其原料按重量份包括：碘0.91份，碘化钾0.91份，聚乙烯吡咯烷酮6.15份，烷基酚聚氧乙烯醚2.7份，壳聚糖0.35份，茶树油0.6份，棕榈油0.4份，失水山梨醇单硬脂酸酯0.15份，异丙醇0.1份，去离子水125份。
1、将碘、碘化钾均匀搅拌3-5分钟，将混合物加入烷基酚聚氧乙烯醚中，再均匀搅拌2小时，制得混合物A；
2、将失水山梨醇单硬脂酸酯、异丙醇加入去离子水中搅拌溶解，加入聚乙烯吡咯烷酮继续搅拌均匀，制成溶液B；
3、将A和B混合搅拌0.5-1小时后一起密闭遮光放置24小时后再均匀搅拌1小时得C；
4、在溶液C中加入壳聚糖、茶树油、棕榈油，搅拌0.5-1小时，制得碘伏消毒液。
本发明具体技术指标见下表：

Claims (3)

1.一种碘伏消毒液，其特征在于：原料按重量份数如下：
碘0.5-1份，碘化钾0.5-1份，聚乙烯吡咯烷酮6-7份，烷基酚聚氧乙烯醚2-3份，壳聚糖0.1-0.5份，茶树油0.5-1份，棕榈油0.1-1份，失水山梨醇单硬脂酸酯0.1-1份，异丙醇0.1-1份，去离子水110-125份。
2.根据权利要求1所述的一种碘伏消毒液，其特征在于：原料按重量份数如下：
碘0.91份，碘化钾0.91份，聚乙烯吡咯烷酮6.15份，烷基酚聚氧乙烯醚2.7份，壳聚糖0.35份，茶树油0.6份，棕榈油0.4份，失水山梨醇单硬脂酸酯0.15份，异丙醇0.1份，去离子水125份。
3.根据权利要求1所述的一种碘伏消毒液的制备方法，其特征在于，包括如下步骤：
1)、将碘、碘化钾均匀搅拌3-5分钟，将混合物加入烷基酚聚氧乙烯醚中，再均匀搅拌2小时，制得混合物A；
2)、将失水山梨醇单硬脂酸酯、异丙醇加入去离子水中搅拌溶解，加入聚乙烯吡咯烷酮继续搅拌均匀，制成溶液B；
3)、将A和B混合搅拌0.5-1小时后一起密闭遮光放置24小时后再均匀搅拌1小时得C；
4)、在溶液C中加入壳聚糖、茶树油、棕榈油，搅拌0.5-1小时，制得碘伏消毒液。
CN201811263777.1A 2018-10-28 2018-10-28 一种复合碘伏消毒液及其制备方法 Pending CN109045066A (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112933161A (zh) * 2021-02-04 2021-06-11 贵州碘雅医疗器械有限公司 一种复合碘伏消毒液
CN113768874A (zh) * 2021-09-16 2021-12-10 四川省伊洁士医疗科技有限公司 一种新型复合碘消毒液及其制备方法
CN115212272A (zh) * 2022-06-14 2022-10-21 河南天厚医疗科技有限公司 一种复合碘伏消毒液及其制备方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112933161A (zh) * 2021-02-04 2021-06-11 贵州碘雅医疗器械有限公司 一种复合碘伏消毒液
CN113768874A (zh) * 2021-09-16 2021-12-10 四川省伊洁士医疗科技有限公司 一种新型复合碘消毒液及其制备方法
CN115212272A (zh) * 2022-06-14 2022-10-21 河南天厚医疗科技有限公司 一种复合碘伏消毒液及其制备方法

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