CN109044875A

CN109044875A - Sodium hyaluronate skin care item and preparation method thereof

Info

Publication number: CN109044875A
Application number: CN201811169670.0A
Authority: CN
Inventors: 蓝雪芬
Original assignee: Mingta Life Science And Technology (shenzhen) Co Ltd
Current assignee: Mingta Life Science And Technology (shenzhen) Co Ltd
Priority date: 2018-10-08
Filing date: 2018-10-08
Publication date: 2018-12-21

Abstract

The present invention relates to technical field of skin care, for the general problem of the effect of anti-aging, a kind of sodium hyaluronate skin care item and preparation method thereof are provided, the technical solution is as follows: a kind of sodium hyaluronate skin care item include: wetting agent 3%-6%；Moisturizer 0.1%-1%；Antiphlogistic 0.1%-0.3%；Antibacterial agent 0.3%-0.8%；Sodium Hyaluronate 0.01%-0.3%；Surplus is aqueous solution；By mass percentage, the aqueous solution is made of the pure water of 75%-85% and the low deuterium-oxide of 15%-25%；Deuterium content is 15ppm-25ppm in the low deuterium-oxide.A kind of preparation method of sodium hyaluronate skin care item, comprising: (1) disinfecting utensils；(2) initial mixture is prepared；(3) intermediate blend is prepared；(4) final mixture is prepared；(5) discharging.By the way that the low deuterium-oxide of 25ppm is added, so that superoxide radical is become normal oxygen molecule, delay senescence.

Description

Sodium hyaluronate skin care item and preparation method thereof

Technical field

The present invention relates to technical field of skin care, more particularly, to a kind of sodium hyaluronate skin care item and preparation method thereof.

Background technique

In skin care item, water occupies very main status, by the nutrition in skin care item while human body is by absorbing water Ingredient draws are into skin, the effect of to play U.S. face skin care.

With social development, demand of the people to skin care item is higher and higher, is that consumer is outstanding by skin care item anti-aging For one of the function of concern.

Caused by aging mainly passes through superoxide radical, this is the monster that occurs on the cell Mitochondria of people, it is specially Door eats up DNA, RNA gene or destroys cell membrane, hinders normal cell division, makes one to cannot get fresh cells and aging is dead It dies.

In general, existing skin care item majority is usually delayed senescence by the member that supplement human body is lost, such as replenishing collagen Deng, fail to tackle the problem at its root, cause delay senescence effect it is general, therefore, there are also improve space.

Summary of the invention

In view of the deficienciess of the prior art, the first object of the present invention is to provide a kind of sodium hyaluronate skin care item and its system Preparation Method has the advantages that anti-aging effect is preferable.

To achieve the above object, the present invention provides the following technical scheme that

A kind of sodium hyaluronate skin care item, the component comprising following mass percent:

By mass percentage, the aqueous solution is made of the pure water of 75%-85% and the low deuterium-oxide of 15%-25%；

Deuterium content is 15ppm-25ppm in the low deuterium-oxide.

By using above-mentioned technical proposal, by the way that the low deuterium-oxide of 25ppm is added, since the molecule of low deuterium-oxide is very active, It will drive all corners that life power element aquo ion goes to human body, by the ability of itself appraising at the current rate of life power element, The electronics attraction of superoxide radical comes, and so that superoxide radical is become normal oxygen molecule, delays senescence；Due to the life of low deuterium-oxide Higher cost is produced, the low deuterium-oxide of 15%-25% is added in aqueous solution, that is, may make in skin care item containing enough life power members Element can play extraordinary anti-aging effects, control the production cost of skin care item, promote convenient for skin care item；Moistened by being added Humectant makes the solid matter in formula easy to dissolve in aqueous solution, easy to produce, improves skin care item quality uniformity；Pass through Moisturizer provides moistening effect, provides anti-inflammatory effects by antiphlogistic, so that skin care item have preferable moisturizing, anti-acne, anti-inflammatory The effect of；Preferable anti-corrosion effect is provided by antibacterial agent, the delay shelf-life keeps the moisture of skin by Sodium Hyaluronate, It moisturizes the skin, increases gloss, and the generation of chapped skin and wrinkle can be prevented, so that skin care item have preferable anti-wrinkle effect.

The present invention is further arranged to: the wetting agent is made of the component of following mass percent:

Propylene glycol 2%-4%

Glycerol 1%-2%.

By using above-mentioned technical proposal, cooperate by using propylene glycol and glycerol imitated so that soaking as wetting agent Fruit is preferable, so that solid component is easily soluble in aqueous solution, improves uniform in quality.

The present invention is further arranged to: the moisturizer is butanediol.

By using above-mentioned technical proposal, provide preferable moistening effect by butanediol, at the same butanediol also use as it is molten Agent uses, and further increases the effect of solid component dissolution.

The present invention is further arranged to: the antiphlogistic is made of the component of following mass percent:

By using above-mentioned technical proposal, by the way that Gentrin Knotweed P.E is added so that skin care item have bring down a fever, relieve pain, anticancer, Anti-inflammatory, antithrombotic and the effect for improving immune system activity, so that anti-acne, color spot effect of dispelling are preferable；It is mentioned by the way that radix scutellariae is added Object is taken, so that skin care item have anti-inflammatory, antimicrobial and antipyretic response, has preferable curative effect for wound；By adding Enter glycyrrhiza glabra root extract, antibacterial, anti-inflammatory, anti-oxidant, anti-aging, antiultraviolet, sun-proof, whitening is bright so that skin care item have The effect of skin and nti-freckle, so that the whitening effect of skin care item is preferable；By the way that german chamomile flower extract is added, so that skin care item have Anti-inflammatory is reduced phlegm and internal heat, effect that is antipruritic and improving color spot, so that the effect of skin care item removal color spot is preferable；By the way that rosemary is added Leaf extract, so that skin care item have the effect of antibacterial, anti-inflammatory, antiviral and antitumor, antiallergy, anti-oxidant and radiation protection, The isolation effect of skin care item is preferable.

The present invention is further arranged to: the antibacterial agent is made of the component of following mass percent:

By using above-mentioned technical proposal, by the way that methyl hydroxybenzoate is added, so as to Gram-negative, positive bacteria, to ferment Female bacterium and mould have stronger inhibiting effect；By the way that glycerol caprylate is added, so as to Gram-negative, positive bacteria, to true Bacterium has stronger inhibiting effect, while also having moistening effect and stuffing effect, so that the moisturizing of skin care item, lubricant effect Preferably；By the way that glycerol monolaurate is added, so that skin care has the ability of stronger resistance sex pheromone infection, can effectively press down Inhibition of HIV, cytomegalovirus, herpesviral, common cold virus and a large amount of bacterium and protozoa processed, and its antibacterial effect is not It is influenced by pH, effect is lasting, and applicability is wide；By the way that Phenoxyethanol is added, so that antibacterial effect is preferable, plays preferable anti-corrosion and make With postponing the shelf-life of skin care item.

The present invention is further arranged to: further include the component of following mass percent:

Gotu Kola P.E 0.01%-0.1%.

By using above-mentioned technical proposal, by the way that Gotu Kola P.E is added so that the preferably compact epidermis of skin care item with Corium coupling part can make skin limber up, and help promotes collagen in skin corium to be formed, and it is existing to facilitate solution cutis laxa As keeping skin smooth flexible, so that anti-wrinkle effect is preferable.

Tea extract 0.01%-0.1%.

By using above-mentioned technical proposal, by the way that tea extract is added, so that skin care item have antibacterial and suppression enzyme effect Fruit, so that skin care item have the effect of preventing skin disease, skin allergy effect, dispel skin pigment.

In view of the deficienciess of the prior art, the second object of the present invention is to provide a kind of sodium hyaluronate skin care item and its system Preparation Method has the advantages that anti-aging effect is preferable.

A kind of preparation method according to above-mentioned sodium hyaluronate skin care item, comprising the following steps:

(1) disinfecting utensils；

(2) initial mixture is prepared, specific as follows:

Aqueous solution, propylene glycol and methyl hydroxybenzoate are stirred evenly and are warming up to 85 DEG C -95 DEG C；

(3) intermediate blend is prepared, specific as follows:

Glycerol and Sodium Hyaluronate are added in the initial mixture that temperature is 45 DEG C -55 DEG C and stirred evenly；

(4) final mixture is prepared, specific as follows:

By Gotu Kola P.E, Gentrin Knotweed P.E, Baical Skullcap root P.E, tea extract, glycyrrhiza glabra root extract, german chamomile It is 40 DEG C -50 DEG C that temperature, which is added, in flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate, Phenoxyethanol It is stirred evenly in intermediate blend；

(5) discharging.

By using above-mentioned technical proposal, by 85 DEG C of -95 DEG C of mixed aqueous solutions, propylene glycol and methyl hydroxybenzoate with reality The effect of existing high-temperature sterilization；By in 45 DEG C of -55 DEG C of addition glycerol and Sodium Hyaluronate and mixing so that Sodium Hyaluronate with And the active matter in glycerol is not destroyed, and guarantees the effect of product quality and skin care；By in the remaining object of 40 DEG C of -50 DEG C of additions Matter avoids each component from inactivating the case where causing skin care item effect to disappear, so that skin care item have to protect the activity of remaining substance Preferable anti-aging effects.

The present invention is further arranged to: discharge temp is 35 DEG C -40 DEG C in the step (5).

It is 35 DEG C -40 DEG C by discharge temp, so that moisture is not easy Yin Wen in skin care item by using above-mentioned technical proposal It spends higher and evaporates, the ratio of each component in skin care item is preferably kept, so that preferable the effect of skin care item.

The present invention is further arranged to: passing through 500 mesh filter-cloth filterings in the step (5) when discharging.

By using above-mentioned technical proposal, after 500 mesh filter-cloth filterings, so that it is impure less in skin care item, it improves Skin care quality.

In conclusion the invention has the following advantages:

1. making superoxide radical become normal oxygen molecule by the low deuterium-oxide that 25ppm is added, delay senescence；

2. the low deuterium-oxide of 15%-25% is added in aqueous solution, can play very since the production cost of low deuterium-oxide is higher Good anti-aging effects, control the production cost of skin care item, promote convenient for skin care item；

3. being led to by realizing the effect of high-temperature sterilization in 85 DEG C of -95 DEG C of mixed aqueous solutions, propylene glycol and methyl hydroxybenzoate It crosses in 45 DEG C of -55 DEG C of addition glycerol and Sodium Hyaluronate and mixes, so that the active matter in Sodium Hyaluronate and glycerol is not It is destroyed, by the remaining substances of 40 DEG C of -50 DEG C of additions, to protect the activity of remaining substance.

Specific embodiment

With reference to embodiments, invention is further described in detail.

Embodiment 1

A kind of sodium hyaluronate skin care item, include the following components'mass percentage:

Wetting agent 3%；Moisturizer 0.1%；Antiphlogistic 0.032%；Antibacterial agent 0.27%；Sodium Hyaluronate 0.01%；It is remaining Amount is aqueous solution；

Aqueous solution is made of 85% pure water and 15% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Wetting agent uses wetting agent generally in the art, specifically: propylene glycol；

Moisturizer uses moisturizer generally in the art, specifically: butanediol；

Antiphlogistic uses antiphlogistic generally in the art, specifically: Gentrin Knotweed P.E；

Antibacterial agent uses antibacterial agent generally in the art, specifically: methyl hydroxybenzoate.

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

Utensil is put into emulsion pot, and water is added, is heated to 100 DEG C, boiling water sterilizes 10 minutes, and taking-up utensil is simultaneously cold But, the water in emulsion pot and drying are drawn off.

(2) initial mixture is prepared, specific as follows:

Wetting agent and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 90 DEG C, keeps the temperature 20 minutes After cool down, formed initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 50 DEG C, Sodium Hyaluronate is added in emulsion pot, 50 DEG C of constant temperature, revolving speed 60r/ Min stirs Temperature fall after 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 45 DEG C, moisturizer, antiphlogistic and antibacterial agent are added in emulsion pot, constant temperature 45 DEG C, revolving speed 45r/min stirs 5min, and revolving speed 60r/min stirs Temperature fall after 5min, forms final mixture；

(5) discharging, specific as follows:

After final mixture is cooled to 38 DEG C, with 500 mesh filter-cloth filterings and discharge, bottling storage.

Embodiment 2

The difference from embodiment 1 is that:

Sodium hyaluronate skin care item include the following components'mass percentage:

Wetting agent 4.5%；Moisturizer 0.5%；Antiphlogistic 0.16%；Antibacterial agent 0.6%；Sodium Hyaluronate 0.2%；Surplus For aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 3

The difference from embodiment 1 is that:

Wetting agent 6%；Moisturizer 1%；Antiphlogistic 0.32%；Antibacterial agent 0.8%；Sodium Hyaluronate 0.3%；Surplus is water Solution.

Aqueous solution is made of 75% pure water and 25% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 4

Propylene glycol 2%；Glycerol 1%；Butanediol 0.1%；Gentrin Knotweed P.E 0.01%；Baical Skullcap root P.E 0.01%；Light fruit Licorice root extract 0.01%；German chamomile flower extract 0.001%；Rosemary leaf extract 0.001%；Methyl hydroxybenzoate 0.05；It is sweet Oily caprylate 0.01%；Glycerol monolaurate 0.01%；Phenoxyethanol 0.2%；Sodium Hyaluronate 0.01%；Surplus is water-soluble Liquid.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 90 DEG C, Heat preservation cools down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 50 DEG C, glycerol and Sodium Hyaluronate are added in emulsion pot, 50 DEG C of constant temperature, are turned Temperature fall after fast 60r/min stirring 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 45 DEG C, by Gentrin Knotweed P.E, Baical Skullcap root P.E, glycyrrhiza glabra root extract, mother Chrysanthemum extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol are added in emulsion pot, permanent 45 DEG C of temperature, revolving speed 45r/min stir 5min, and revolving speed 60r/min stirs Temperature fall after 5min, form final mixture；

(5) discharging, specific as follows:

Embodiment 5

Difference with embodiment 4 is:

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.05%；Baical Skullcap root P.E 0.05%；Light Fruit licorice root extract 0.05%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.05%；Glycerol monolaurate 0.05%；Phenoxyethanol 0.3%；Sodium Hyaluronate 0.15%；Surplus is water-soluble Liquid.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 6

Difference with embodiment 4 is:

Propylene glycol 4%；Glycerol 2%；Butanediol 1%；Gentrin Knotweed P.E 0.1%；Baical Skullcap root P.E 0.1%；Glycyrrhiza glabra Root extract 0.1%；German chamomile flower extract 0.01%；Rosemary leaf extract 0.01%；Methyl hydroxybenzoate 0.2%；Glycerol octanoic acid Ester 0.1%；Glycerol monolaurate 0.1%；Phenoxyethanol 0.4%；Sodium Hyaluronate 0.3%；Surplus is aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 7

Difference with embodiment 4 is:

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.02%；Baical Skullcap root P.E 0.02%；Light Fruit licorice root extract 0.01%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.0105%；Glycerol monolaurate 0.0105%；Phenoxyethanol 0.329%；Sodium Hyaluronate 0.07%；Surplus For aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 8

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.02%；Baical Skullcap root P.E 0.02%；Light Fruit licorice root extract 0.01%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.0105%；Glycerol monolaurate 0.0105%；Phenoxyethanol 0.329%；Sodium Hyaluronate 0.07%；Accumulated snow Careless extract 0.01%；Tea extract 0.01%；Surplus is aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and water are added in emulsion pot, revolving speed 60r/min is stirred and heated to 90 DEG C, heat preservation Cool down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 45 DEG C, Gotu Kola P.E, tea extract, Gentrin Knotweed P.E, radix scutellariae are mentioned Take object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol is added in emulsion pot, and 45 DEG C of constant temperature, revolving speed 45r/min stirs 5min, drops naturally after revolving speed 60r/min stirring 5min Temperature forms final mixture；

(5) discharging, specific as follows:

Embodiment 9

Difference with embodiment 8 is:

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.02%；Baical Skullcap root P.E 0.02%；Light Fruit licorice root extract 0.01%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.0105%；Glycerol monolaurate 0.0105%；Phenoxyethanol 0.329%；Sodium Hyaluronate 0.07%；Accumulated snow Careless extract 0.05%；Tea extract 0.05%；Surplus is aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 10

Difference with embodiment 8 is:

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.02%；Baical Skullcap root P.E 0.02%；Light Fruit licorice root extract 0.01%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.0105%；Glycerol monolaurate 0.0105%；Phenoxyethanol 0.329%；Sodium Hyaluronate 0.07%；Accumulated snow Careless extract 0.1%；Tea extract 0.1%；Surplus is aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 11

Difference with embodiment 8 is:

Propylene glycol 3%；Glycerol 1.5%；Butanediol 0.5%；Gentrin Knotweed P.E 0.02%；Baical Skullcap root P.E 0.02%；Light Fruit licorice root extract 0.01%；German chamomile flower extract 0.005%；Rosemary leaf extract 0.005%；Methyl hydroxybenzoate 0.1%； Glycerol caprylate 0.0105%；Glycerol monolaurate 0.0105%；Phenoxyethanol 0.329%；Sodium Hyaluronate 0.07%；Accumulated snow Careless extract 0.05%；Tea extract 0.01%；Surplus is aqueous solution.

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 12

Difference with embodiment 11 is:

Aqueous solution is made of 85% pure water and 15% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 13

Difference with embodiment 11 is:

Aqueous solution is made of 82.5% pure water and 17.5% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 14

Difference with embodiment 11 is:

Aqueous solution is made of 77.5% pure water and 22.5% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 15

Difference with embodiment 11 is:

Aqueous solution is made of 75% pure water and 25% low deuterium-oxide；

Deuterium content is 25ppm in the low deuterium-oxide.

Embodiment 16

Difference with embodiment 11 is:

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 20ppm in the low deuterium-oxide.

Embodiment 17

Difference with embodiment 11 is:

Aqueous solution is made of 80% pure water and 20% low deuterium-oxide；

Deuterium content is 15ppm in the low deuterium-oxide.

Embodiment 18

Difference with embodiment 11 is:

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 85 DEG C, Heat preservation cools down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 45 DEG C, glycerol and Sodium Hyaluronate are added in emulsion pot, 45 DEG C of constant temperature, are turned Temperature fall after fast 60r/min stirring 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 40 DEG C, Gotu Kola P.E, tea extract, Gentrin Knotweed P.E, radix scutellariae are mentioned Take object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol is added in emulsion pot, and 40 DEG C of constant temperature, revolving speed 45r/min stirs 5min, drops naturally after revolving speed 60r/min stirring 5min Temperature forms final mixture；

(5) discharging, specific as follows:

After final mixture is cooled to 35 DEG C, with 500 mesh filter-cloth filterings and discharge, bottling storage.

Embodiment 19

Difference with embodiment 11 is:

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 95 DEG C, Heat preservation cools down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 55 DEG C, glycerol and Sodium Hyaluronate are added in emulsion pot, 55 DEG C of constant temperature, are turned Temperature fall after fast 60r/min stirring 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 50 DEG C, Gotu Kola P.E, tea extract, Gentrin Knotweed P.E, radix scutellariae are mentioned Take object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol is added in emulsion pot, and 50 DEG C of constant temperature, revolving speed 45r/min stirs 5min, drops naturally after revolving speed 60r/min stirring 5min Temperature forms final mixture；

(5) discharging, specific as follows:

After final mixture is cooled to 40 DEG C, with 500 mesh filter-cloth filterings and discharge, bottling storage.

Comparative example 1

Difference with embodiment 11 is:

Low deuterium-oxide is not included in aqueous solution wherein.

Comparative example 2

The sodium hyaluronate skin care item A without low deuterium-oxide of market purchase.

Comparative example 3

The sodium hyaluronate skin care item B without low deuterium-oxide of market purchase.

Comparative example 4

Difference with embodiment 11 is:

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 80 DEG C, Heat preservation cools down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 60 DEG C, glycerol and Sodium Hyaluronate are added in emulsion pot, 60 DEG C of constant temperature, are turned Temperature fall after fast 60r/min stirring 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 55 DEG C, Gotu Kola P.E, tea extract, Gentrin Knotweed P.E, radix scutellariae are mentioned Take object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol is added in emulsion pot, and 55 DEG C of constant temperature, revolving speed 45r/min stirs 5min, drops naturally after revolving speed 60r/min stirring 5min Temperature forms final mixture；

(5) discharging, specific as follows:

Comparative example 5

Difference with embodiment 11 is:

Sodium hyaluronate skin care item the preparation method is as follows:

(1) disinfecting utensils, specific as follows:

(2) initial mixture is prepared, specific as follows:

Propylene glycol, methyl hydroxybenzoate and aqueous solution are added in emulsion pot, revolving speed 60r/min is stirred and heated to 75 DEG C, Heat preservation cools down after twenty minutes, forms initial mixture.

(3) intermediate blend is prepared, specific as follows:

After initial mixture is cooled to 65 DEG C, glycerol and Sodium Hyaluronate are added in emulsion pot, 65 DEG C of constant temperature, are turned Temperature fall after fast 60r/min stirring 10min, forms intermediate blend；

(4) final mixture is prepared, specific as follows:

After intermediate blend is cooled to 60 DEG C, Gotu Kola P.E, tea extract, Gentrin Knotweed P.E, radix scutellariae are mentioned Take object, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract, glycerol caprylate, glycerol monolaurate and Phenoxyethanol is added in emulsion pot, and 60 DEG C of constant temperature, revolving speed 45r/min stirs 5min, drops naturally after revolving speed 60r/min stirring 5min Temperature forms final mixture；

(5) discharging, specific as follows:

Specific test data is shown in Table 1-5.

Experiment 1

The product that the production of each embodiment obtains is applied on small white mouse skin of back, once in the morning and once at night, after seven days, By detecting luminous intensity by fluorescent quantitative detection device in small white mouse dorsal injection luminol reagent.

Luminol reagent concentration is 0.2%, and injection rate 10ml is injected using hypodermic injection.

First small white mouse is anaesthetized to improve detection accuracy before test.

Experiment 2

Supernatant water is dripped on slide, and the product sampling 1g that the production of each embodiment obtains is instilled in clear water, dyestuff is added.It is logical Optical microphotograph sem observation is crossed, amplification factor is 800 times, and heart position takes 3 points of observation at random in a liquid, records in range of observation Bacterial number living is simultaneously averaged.

Table 1

	Embodiment 1	Embodiment 2	Embodiment 3	Comparative example 1	Comparative example 2	Comparative example 3
							Luminous intensity	2183	1673	1553	9898	9467	9683
Bacterial number living	23	22	25	26	24	51
							Appearance	It is transparent	It is transparent	It is transparent	It is transparent	It is transparent	It is transparent

Table 2

Table 3

	Embodiment 8	Embodiment 9	Embodiment 10	Embodiment 11
					Luminous intensity	1687	1711	1702	1693
Bacterial number living	22	27	21	23
					Appearance	It is transparent	It is transparent	It is transparent	It is transparent

Table 4

Table 5

	Embodiment 18	Embodiment 19	Comparative example 4	Comparative example 5
					Luminous intensity	1683	1679	1695	1673
Bacterial number living	12	33	63	103
					Appearance	It is transparent	It is transparent	Muddy, suspension	Muddy, precipitating

It can be obtained by table 1, after low deuterium-oxide is added, can obviously reduce luminous intensity, when being detected using chemoluminescence method, shone Intensity is lower, it was demonstrated that superoxide radical concentration is lower, it is clear that after low deuterium-oxide is added, the superoxide radical in biology can be made dense Degree is decreased obviously, and then reduces the case where superoxide radical destroys cell, realizes the effect of anti-aging.

It can be obtained by table 2- table 3, each component is added and each component content changes, super oxygen is eliminated certainly to low deuterium-oxide By the effect of base without obvious negative effect, that is, low deuterium-oxide, which is added, to act synergistically with the various function ingredients of addition, improve skin care Product skin effect.

It can be obtained by table 3 and table 4, when the deuterium content of low deuterium-oxide is 25ppm, when low deuterium-oxide content is lower than 20%, The content for increasing low deuterium-oxide helps to be substantially reduced luminous intensity, and after low deuterium-oxide content is greater than 20%, reduce luminous intensity Amplitude be greatly decreased；When low deuterium-oxide content is 20%, reduce the deuterium content of low deuterium-oxide, reduce the amplitude of luminous intensity compared with It is few；As it can be seen that the effect of elimination superoxide radical is preferable and sexual valence is relatively high when low deuterium-oxide content accounts for the 20% of water, control Cost, so that product is easy to spread.

It can be obtained by table 5, after the processing temperature of initial mixture is lower than 85 DEG C, bacterial number of living in product substantially increases Add, so that Disinfection Effect is decreased obviously, reduces product quality.

After the processing temperature of intermediate blend is higher than 55 DEG C and final mixture processing temperature is greater than 50 DEG C, skin care item Significant change occurs for appearance, muddy even precipitating occurs, this is because each component occurs caused by deactivation phenomenom, it will be so that shield The quality of skin product declines.

Therefore the processing temperature control of initial mixture is controlled in the processing temperature of 85 DEG C -95 DEG C, intermediate blend 45 DEG C -55 DEG C, the processing temperature of final mixture control at 40 DEG C -50 DEG C, the skin care quality produced is preferable.

The embodiment of present embodiment is presently preferred embodiments of the present invention, not limits protection of the invention according to this Range, therefore: the equivalence changes that all structures under this invention, shape, principle are done, should all be covered by protection scope of the present invention it It is interior.

Claims

1. a kind of sodium hyaluronate skin care item, it is characterized in that: the component comprising following mass percent:

Wetting agent 3%-6%

Moisturizer 0.1%-1%

Antiphlogistic 0.1%-0.3%

Antibacterial agent 0.3%-0.8%

Sodium Hyaluronate 0.01%-0.3%

Surplus is aqueous solution；

Deuterium content is 15ppm-25ppm in the low deuterium-oxide.

2. sodium hyaluronate skin care item according to claim 1, it is characterized in that: group of the wetting agent by following mass percent Divide and constitute:

Propylene glycol 2%-4%

Glycerol 1%-2%.

3. sodium hyaluronate skin care item according to claim 2, it is characterized in that: the moisturizer is butanediol.

4. sodium hyaluronate skin care item according to claim 3, it is characterized in that: group of the antiphlogistic by following mass percent Divide and constitute:

Gentrin Knotweed P.E 0.01%-0.1%

Baical Skullcap root P.E 0.01%-0.1%

Glycyrrhiza glabra root extract 0.01%-0.1%

German chamomile flower extract 0.001%-0.01%

Rosemary leaf extract 0.001%-0.01%.

5. sodium hyaluronate skin care item according to claim 4, it is characterized in that: group of the antibacterial agent by following mass percent Divide and constitute:

Methyl hydroxybenzoate 0.05-0.2%

Glycerol caprylate 0.01%-0.1%

Glycerol monolaurate 0.01%-0.1%

Phenoxyethanol 0.2%-0.4%.

6. sodium hyaluronate skin care item according to claim 5, it is characterized in that: further including the component of following mass percent:

Gotu Kola P.E 0.01%-0.1%.

7. sodium hyaluronate skin care item according to claim 6, it is characterized in that: further including the component of following mass percent:

Tea extract 0.01%-0.1%.

8. a kind of preparation method of sodium hyaluronate skin care item according to claim 7, it is characterized in that: the following steps are included:

(1) disinfecting utensils；

(2) initial mixture is prepared, specific as follows:

(3) intermediate blend is prepared, specific as follows:

(4) final mixture is prepared, specific as follows:

Gotu Kola P.E, Gentrin Knotweed P.E, Baical Skullcap root P.E, tea extract, glycyrrhiza glabra root extract, Flos Chrysanthemi are mentioned Take object, rosemary leaf extract, glycerol caprylate, glycerol monolaurate, Phenoxyethanol that the centre that temperature is 40 DEG C -50 DEG C is added It is stirred evenly in mixture；

(5) discharging.

9. preparation method according to claim 8, it is characterized in that: discharge temp is 35 DEG C -40 DEG C in the step (5).

10. preparation method according to claim 9, it is characterized in that: passing through 500 mesh filter clothes in the step (5) when discharging Filtering.