CN109010209A - A kind of wet tissue special suitable for patients with rhinitis - Google Patents
A kind of wet tissue special suitable for patients with rhinitis Download PDFInfo
- Publication number
- CN109010209A CN109010209A CN201811067449.4A CN201811067449A CN109010209A CN 109010209 A CN109010209 A CN 109010209A CN 201811067449 A CN201811067449 A CN 201811067449A CN 109010209 A CN109010209 A CN 109010209A
- Authority
- CN
- China
- Prior art keywords
- powder
- mixed
- rhinitis
- wet tissue
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses a kind of wet tissue specials suitable for patients with rhinitis, are related to wet tissue technical field, are combined by spunlace non-woven cloth and maceration extract, and the maceration extract quality is 2.2-2.4 times of spunlace non-woven cloth quality；The present invention provides a kind of wet tissue specials suitable for patients with rhinitis can effectively improve rhinitis situation by the nose of wet tissue prepared by the present invention wiping patients with rhinitis.
Description
Technical field
The invention belongs to wet tissue technical fields, and in particular to a kind of wet tissue special suitable for patients with rhinitis.
Background technique
Wet tissue is a kind of a kind of paper handkerchief for scrape skin made of pure water, spunlace non-woven cloth and propylene glycol.In recent years
Come, since wet tissue product carries and uses more convenient, has become the daily of the indispensabilities such as most in other, trip, office
Product.
Allergic rhinitis is a kind of common upper respiratory disease, is mainly shown as rhinorrhea, sneezing, nasal obstruction and rhiocnesmus
Etc. symptoms.In recent years, due to social development and the influence of environmental factor, there are about 400,000,000 patients in the whole world, and becoming of gradually increasing is presented
Gesture, illness rate is 8.7% ~ 24.1% for each person for China.But since this disease pathogenesis is indefinite, modern medicine be there is no
The specific medicament for treating this disease.In order to alleviate nasal obstruction and runny nose symptom, many patients are other than taking various Chinese and western drugs orally, also
Selection alleviate local symptom by instruments such as nasal cleaner, nebulizers.Regardless for the treatment of means, it is impossible to make nose
Plug and runny nose symptom improve at once, and patient still needs to be blown one's nose with a large amount of paper handkerchiefs, and paper handkerchief is used for a long time and blows one's nose and can lead
Redness, pain, furfur around nose are caused, serious person influences daily life and beauty.
Summary of the invention
The purpose of the present invention is being directed to existing problem, a kind of wet tissue special suitable for patients with rhinitis is provided.
The present invention is achieved by the following technical solutions:
A kind of wet tissue special suitable for patients with rhinitis, is combined by spunlace non-woven cloth and maceration extract, the maceration extract quality
It is 2.2-2.4 times of spunlace non-woven cloth quality, the maceration extract is made of following component by weight: propylene glycol 1-3, cape jasmine
Glycosides 0.012-0.015, water chestnut skin and dandelion composite extract 0.05-0.09, the flower bud of lily magnolia and humulus grass composite extract 0.14-
0.18, pure water 102-105.
Further, the water chestnut skin and dandelion composite extract the preparation method comprises the following steps:
Water chestnut skin is put into soak at room temperature 40min in sodium chloride solution, is then filtered, is cleaned using cleaning, drying to constant weight, so
Water chestnut skin is crushed afterwards, obtains water chestnut skin powder, dandelion powder is impregnated into 30min at 40 DEG C using citric acid solution, is then passed through
Filtering is cleaned using cleaning, and drying to constant weight, then crushes dandelion, obtains dandelion powder, and water chestnut skin powder and Pu is public
English powder is uniformly mixed by 3:1 mass ratio, obtains mixed-powder, and mixed-powder is mixed with ethanol solution by 1:6 mass ratio
Afterwards, it is stirred 2 hours at 60 DEG C, is then filtered, obtains filtrate and filter residue, filter residue is repeated to extract 1 time, merging is filtered twice
It is dry to get water chestnut skin and dandelion extract to be carried out rotary evaporation by liquid for combined filtrate.
Further, the sodium chloride solution mass fraction is Ei 0.26%, and the citric acid solution mass fraction is
0.55%。
Further, the water chestnut skin Powder Particle Size is 100 mesh, and the dandelion Powder Particle Size is 80 mesh.
Further, the ethanol solution mass fraction is 78%.
Further, the flower bud of lily magnolia and humulus grass composite extract the preparation method comprises the following steps:
(1) flower bud of lily magnolia and humulus grass are respectively crushed into powder, obtain flower bud of lily magnolia powder and humulus grass powder, flower bud of lily magnolia powder and humulus grass powder are pressed into 1:1.2
Mass ratio is uniformly admixed together, obtains mixed-powder；
(2) grifola frondosus species suspension is mixed into progress fermented and cultured by 1:10 mass ratio with culture medium, obtains grifola frondosus
Mycelium fermentation broth is stirred 2 hours maitake mushroom mycelia fermentation liquid with 3500r/min revolving speed, obtains treatment fluid；
(3) after mixed-powder being mixed with the sodium hydroxide solution that concentration is 0.8mol/L by 1:5 mass ratio, at 80 DEG C,
15min is impregnated under 0.5MPa pressure, is then filtered again, is cleaned using clear water to neutrality, naturally dry, and it is mixed to obtain alkali process
Close powder；
(4) alkali process mixed-powder obtained above and treatment fluid obtained above are mixed in 100-105g:220mL ratio,
It is placed 20 hours at 35 DEG C, obtains fermentation treatment fluid, add the ethyl alcohol of its quality 70%, into fermentation treatment fluid with 2000r/
Min revolving speed stirs 2 hours, is then filtered, obtains filtrate, carries out steam sterilizing to filtrate, then carries out to filtrate reverse osmosis
Processing removes macromolecular substances, dry to get the flower bud of lily magnolia and humulus grass composite extract then carrying out rotary evaporation again.
Further, step (1) the grifola frondosus species suspension grifola frondosus strain concentration is 1 × 105cfu/mL。
Further, step (1) fermented and cultured is to cultivate 2 days at 40 DEG C.
Further, step (1) described culture medium is made of following component by weight: glucose 1.5, magnesium sulfate
0.09, zinc chloride 0.06, potassium dihydrogen phosphate 0.15, sodium dihydrogen phosphate 0.13, pure water 100.
The utility model has the advantages that the present invention provides a kind of wet tissue specials suitable for patients with rhinitis, by prepared by the present invention wet
Towel wipe patients with rhinitis nose, can effectively improve rhinitis situation, by using spunlace non-woven cloth with it is prepared by the present invention
The compounded wet tissue of maceration extract, it is smaller for the irritation of patient's schneiderian membrance under the comprehensive function of maceration extract active constituent,
By wiping after, can preferably improve patient's nose redness symptom, mainly with improve improve rhinitis secondary symptom rhiocnesmus and
Based on redness, find out through overtesting: the rat after wet tissue prepared by the present invention wiping scratches nose number and is greatly lowered, nose
Red and swollen situation slows down, significant effect, using single Flos Magnoliae extract or the humulus grass extracting solution substitution flower bud of lily magnolia and humulus grass in maceration extract
Composite extract is substantially reduced rat nose allergic conditions remission effect, and without adding, the flower bud of lily magnolia and humulus grass are compound to be mentioned
When taking object, wet tissue wipes rat nose, and allergic conditions are not obviously improved, it can be seen that, water chestnut skin with dandelion is compound mentions
Taking object for rat nose allergic conditions, there is no direct improvements, without adding water chestnut skin and dandelion compound collecting
Wet tissue is substantially reduced rat nose allergic conditions improvement again when object, it is seen then that water chestnut skin and dandelion composite extract
Play the role of that the flower bud of lily magnolia and humulus grass composite extract is promoted to improve rat nose allergic conditions.
Specific embodiment
Embodiment 1
A kind of wet tissue special suitable for patients with rhinitis, is combined by spunlace non-woven cloth and maceration extract, the maceration extract quality
It is 2.2 times of spunlace non-woven cloth quality, the maceration extract is made of following component by weight: propylene glycol 1, Gardenoside
0.012, water chestnut skin and dandelion composite extract 0.05, the flower bud of lily magnolia and humulus grass composite extract 0.14, pure water 102.
Further, the water chestnut skin and dandelion composite extract the preparation method comprises the following steps:
Water chestnut skin is put into soak at room temperature 40min in sodium chloride solution, is then filtered, is cleaned using cleaning, drying to constant weight, so
Water chestnut skin is crushed afterwards, obtains water chestnut skin powder, dandelion powder is impregnated into 30min at 40 DEG C using citric acid solution, is then passed through
Filtering is cleaned using cleaning, and drying to constant weight, then crushes dandelion, obtains dandelion powder, and water chestnut skin powder and Pu is public
English powder is uniformly mixed by 3:1 mass ratio, obtains mixed-powder, and mixed-powder is mixed with ethanol solution by 1:6 mass ratio
Afterwards, it is stirred 2 hours at 60 DEG C, is then filtered, obtains filtrate and filter residue, filter residue is repeated to extract 1 time, merging is filtered twice
It is dry to get water chestnut skin and dandelion extract to be carried out rotary evaporation by liquid for combined filtrate.
Further, the sodium chloride solution mass fraction is Ei 0.26%, and the citric acid solution mass fraction is
0.55%。
Further, the water chestnut skin Powder Particle Size is 100 mesh, and the dandelion Powder Particle Size is 80 mesh.
Further, the ethanol solution mass fraction is 78%.
Further, the flower bud of lily magnolia and humulus grass composite extract the preparation method comprises the following steps:
(1) flower bud of lily magnolia and humulus grass are respectively crushed into powder, obtain flower bud of lily magnolia powder and humulus grass powder, flower bud of lily magnolia powder and humulus grass powder are pressed into 1:1.2
Mass ratio is uniformly admixed together, obtains mixed-powder；
(2) grifola frondosus species suspension is mixed into progress fermented and cultured by 1:10 mass ratio with culture medium, obtains grifola frondosus
Mycelium fermentation broth is stirred 2 hours maitake mushroom mycelia fermentation liquid with 3500r/min revolving speed, obtains treatment fluid；
(3) after mixed-powder being mixed with the sodium hydroxide solution that concentration is 0.8mol/L by 1:5 mass ratio, at 80 DEG C,
15min is impregnated under 0.5MPa pressure, is then filtered again, is cleaned using clear water to neutrality, naturally dry, and it is mixed to obtain alkali process
Close powder；
(4) alkali process mixed-powder obtained above and treatment fluid obtained above are mixed in 100g:220mL ratio, 35
It is placed 20 hours at DEG C, obtains fermentation treatment fluid, the ethyl alcohol of its quality 70% is added into fermentation treatment fluid, turned with 2000r/min
Speed stirring 2 hours, is then filtered, obtains filtrate, carries out steam sterilizing to filtrate, then carries out reverse osmosis treatment to filtrate,
Macromolecular substances are removed, it is dry to get the flower bud of lily magnolia and humulus grass composite extract then carrying out rotary evaporation again.
Further, step (1) the grifola frondosus species suspension grifola frondosus strain concentration is 1 × 105cfu/mL。
Further, step (1) fermented and cultured is to cultivate 2 days at 40 DEG C.
Further, step (1) described culture medium is made of following component by weight: glucose 1.5, magnesium sulfate
0.09, zinc chloride 0.06, potassium dihydrogen phosphate 0.15, sodium dihydrogen phosphate 0.13, pure water 100.
Embodiment 2
A kind of wet tissue special suitable for patients with rhinitis, is combined by spunlace non-woven cloth and maceration extract, the maceration extract quality
It is 2.4 times of spunlace non-woven cloth quality, the maceration extract is made of following component by weight: propylene glycol 3, Gardenoside
0.015, water chestnut skin and dandelion composite extract 0.09, the flower bud of lily magnolia and humulus grass composite extract 0.18, pure water 105.
Further, the water chestnut skin and dandelion composite extract the preparation method comprises the following steps:
Water chestnut skin is put into soak at room temperature 40min in sodium chloride solution, is then filtered, is cleaned using cleaning, drying to constant weight, so
Water chestnut skin is crushed afterwards, obtains water chestnut skin powder, dandelion powder is impregnated into 30min at 40 DEG C using citric acid solution, is then passed through
Filtering is cleaned using cleaning, and drying to constant weight, then crushes dandelion, obtains dandelion powder, and water chestnut skin powder and Pu is public
English powder is uniformly mixed by 3:1 mass ratio, obtains mixed-powder, and mixed-powder is mixed with ethanol solution by 1:6 mass ratio
Afterwards, it is stirred 2 hours at 60 DEG C, is then filtered, obtains filtrate and filter residue, filter residue is repeated to extract 1 time, merging is filtered twice
It is dry to get water chestnut skin and dandelion extract to be carried out rotary evaporation by liquid for combined filtrate.
Further, the sodium chloride solution mass fraction is Ei 0.26%, and the citric acid solution mass fraction is
0.55%。
Further, the water chestnut skin Powder Particle Size is 100 mesh, and the dandelion Powder Particle Size is 80 mesh.
Further, the ethanol solution mass fraction is 78%.
Further, the flower bud of lily magnolia and humulus grass composite extract the preparation method comprises the following steps:
(1) flower bud of lily magnolia and humulus grass are respectively crushed into powder, obtain flower bud of lily magnolia powder and humulus grass powder, flower bud of lily magnolia powder and humulus grass powder are pressed into 1:1.2
Mass ratio is uniformly admixed together, obtains mixed-powder；
(2) grifola frondosus species suspension is mixed into progress fermented and cultured by 1:10 mass ratio with culture medium, obtains grifola frondosus
Mycelium fermentation broth is stirred 2 hours maitake mushroom mycelia fermentation liquid with 3500r/min revolving speed, obtains treatment fluid；
(3) after mixed-powder being mixed with the sodium hydroxide solution that concentration is 0.8mol/L by 1:5 mass ratio, at 80 DEG C,
15min is impregnated under 0.5MPa pressure, is then filtered again, is cleaned using clear water to neutrality, naturally dry, and it is mixed to obtain alkali process
Close powder；
(4) alkali process mixed-powder obtained above and treatment fluid obtained above are mixed in 105g:220mL ratio, 35
It is placed 20 hours at DEG C, obtains fermentation treatment fluid, the ethyl alcohol of its quality 70% is added into fermentation treatment fluid, turned with 2000r/min
Speed stirring 2 hours, is then filtered, obtains filtrate, carries out steam sterilizing to filtrate, then carries out reverse osmosis treatment to filtrate,
Macromolecular substances are removed, it is dry to get the flower bud of lily magnolia and humulus grass composite extract then carrying out rotary evaporation again.
Further, step (1) the grifola frondosus species suspension grifola frondosus strain concentration is 1 × 105cfu/mL。
Further, step (1) fermented and cultured is to cultivate 2 days at 40 DEG C.
Further, step (1) described culture medium is made of following component by weight: glucose 1.5, magnesium sulfate
0.09, zinc chloride 0.06, potassium dihydrogen phosphate 0.15, sodium dihydrogen phosphate 0.13, pure water 100.
Embodiment 3
A kind of wet tissue special suitable for patients with rhinitis, is combined by spunlace non-woven cloth and maceration extract, the maceration extract quality
It is 2.3 times of spunlace non-woven cloth quality, the maceration extract is made of following component by weight: propylene glycol 2, Gardenoside
0.013, water chestnut skin and dandelion composite extract 0.06, the flower bud of lily magnolia and humulus grass composite extract 0.15, pure water 103.
Further, the water chestnut skin and dandelion composite extract the preparation method comprises the following steps:
Water chestnut skin is put into soak at room temperature 40min in sodium chloride solution, is then filtered, is cleaned using cleaning, drying to constant weight, so
Water chestnut skin is crushed afterwards, obtains water chestnut skin powder, dandelion powder is impregnated into 30min at 40 DEG C using citric acid solution, is then passed through
Filtering is cleaned using cleaning, and drying to constant weight, then crushes dandelion, obtains dandelion powder, and water chestnut skin powder and Pu is public
English powder is uniformly mixed by 3:1 mass ratio, obtains mixed-powder, and mixed-powder is mixed with ethanol solution by 1:6 mass ratio
Afterwards, it is stirred 2 hours at 60 DEG C, is then filtered, obtains filtrate and filter residue, filter residue is repeated to extract 1 time, merging is filtered twice
It is dry to get water chestnut skin and dandelion extract to be carried out rotary evaporation by liquid for combined filtrate.
Further, the sodium chloride solution mass fraction is Ei 0.26%, and the citric acid solution mass fraction is
0.55%。
Further, the water chestnut skin Powder Particle Size is 100 mesh, and the dandelion Powder Particle Size is 80 mesh.
Further, the ethanol solution mass fraction is 78%.
Further, the flower bud of lily magnolia and humulus grass composite extract the preparation method comprises the following steps:
(1) flower bud of lily magnolia and humulus grass are respectively crushed into powder, obtain flower bud of lily magnolia powder and humulus grass powder, flower bud of lily magnolia powder and humulus grass powder are pressed into 1:1.2
Mass ratio is uniformly admixed together, obtains mixed-powder；
(2) grifola frondosus species suspension is mixed into progress fermented and cultured by 1:10 mass ratio with culture medium, obtains grifola frondosus
Mycelium fermentation broth is stirred 2 hours maitake mushroom mycelia fermentation liquid with 3500r/min revolving speed, obtains treatment fluid；
(3) after mixed-powder being mixed with the sodium hydroxide solution that concentration is 0.8mol/L by 1:5 mass ratio, at 80 DEG C,
15min is impregnated under 0.5MPa pressure, is then filtered again, is cleaned using clear water to neutrality, naturally dry, and it is mixed to obtain alkali process
Close powder；
(4) alkali process mixed-powder obtained above and treatment fluid obtained above are mixed in 103g:220mL ratio, 35
It is placed 20 hours at DEG C, obtains fermentation treatment fluid, the ethyl alcohol of its quality 70% is added into fermentation treatment fluid, turned with 2000r/min
Speed stirring 2 hours, is then filtered, obtains filtrate, carries out steam sterilizing to filtrate, then carries out reverse osmosis treatment to filtrate,
Macromolecular substances are removed, it is dry to get the flower bud of lily magnolia and humulus grass composite extract then carrying out rotary evaporation again.
Further, step (1) the grifola frondosus species suspension grifola frondosus strain concentration is 1 × 105cfu/mL。
Further, step (1) fermented and cultured is to cultivate 2 days at 40 DEG C.
Further, step (1) described culture medium is made of following component by weight: glucose 1.5, magnesium sulfate
0.09, zinc chloride 0.06, potassium dihydrogen phosphate 0.15, sodium dihydrogen phosphate 0.13, pure water 100.
Comparative example 1: it is only that with the difference of embodiment 1 and the flower bud of lily magnolia and humulus grass composite extract is replaced with into Flos Magnoliae extract.
Comparative example 2: it is only that with the difference of embodiment 1 and the flower bud of lily magnolia and humulus grass composite extract is replaced with into Herba humuli scandentis extract.
Comparative example 3: it is only that with the difference of embodiment 1 and does not add water chestnut skin and dandelion composite extract.
Comparative example 4: it is only that with the difference of embodiment 1 and does not add the flower bud of lily magnolia and humulus grass composite extract.
SPF grades of experimental animal male SD rat 70,180~210g of weight；
The foundation and evaluation of AR rat model
Comprehensive country's AR modeling method simultaneously improves, and is randomly divided into just after taking 70 adaptable fed 1w of male SD rat
Often group 10, modeling group 60.Add Al(OH with ovalbumin (OVA) 1g)3Suspension is made in powder 3g and physiological saline 100mL
As antigen.Give the every mouse of modeling rat to be injected intraperitoneally OVA suspension 1mL, the next day 1 time, totally 7 times, for basic sensitization.Again with 5%
OVA physiological saline collunarium attack bilateral nasal cavity, every 50 μ L of side, one time a day, totally 14 times.Normal group is replaced with same amount of normal saline
OVA suspension carries out intraperitoneal injection and collunarium attack.Model evaluation, for main observed content, is given certainly with sniffle and sign
Sensitization medicine starts, and is score basis, each symptom superposition integral, total score >=5 point person according to rhiocnesmus, sneeze, runny nose degree, number etc.
Decision model replicates successfully, and observing time is that the results are shown in Table 1 after each sensitization in 3 min；
Table 1
After continuing for stimulation 30 days, it is wet that modeling success rat is randomly divided into blank control group, embodiment wet tissue group, comparative example
Towel group, physiological saline wet tissue group, dried towel group drip 50 μ L normal saline solutions, model group in the every side nostril of normal rats
After 50 μ L ovalbumin mixed liquors are dripped in the every side nostril of rat, record rat makes a noise within 3min scratches nose number, and observes rat nose
Portion's redness situation after observation, wipes rat nose according still further to grouping respectively, wipes 30 times altogether, records after wiping every
Nose number is scratched within rat 3min, and observes rat nose redness situation；
Table 2
As can be seen from Table 2, the rat after wet tissue prepared by the present invention wiping scratches nose number and is greatly lowered, and nose is red and swollen
Situation slows down, significant effect, compound using single Flos Magnoliae extract or the humulus grass extracting solution substitution flower bud of lily magnolia and humulus grass in maceration extract
Extract is substantially reduced rat nose allergic conditions remission effect, without adding the flower bud of lily magnolia and humulus grass composite extract
When, wet tissue wipes rat nose, and allergic conditions are not obviously improved, it can be seen that, water chestnut skin and dandelion composite extract
For rat nose allergic conditions, there is no direct improvements, when without adding water chestnut skin and dandelion composite extract
Wet tissue is substantially reduced rat nose allergic conditions improvement again, it is seen then that water chestnut skin is played with dandelion composite extract
The flower bud of lily magnolia and humulus grass composite extract is promoted to improve the effect of rat nose allergic conditions.
Claims (9)
1. a kind of wet tissue special suitable for patients with rhinitis, which is characterized in that be combined by spunlace non-woven cloth and maceration extract, institute
2.2-2.4 times that maceration extract quality is spunlace non-woven cloth quality is stated, the maceration extract is made of following component by weight: third
Glycol 1-3, Gardenoside 0.012-0.015, water chestnut skin and dandelion composite extract 0.05-0.09, the flower bud of lily magnolia and humulus grass is compound mentions
Take object 0.14-0.18, pure water 102-105.
2. a kind of wet tissue special suitable for patients with rhinitis as described in claim 1, which is characterized in that the water chestnut skin and Pu
Public English composite extract the preparation method comprises the following steps:
Water chestnut skin is put into soak at room temperature 40min in sodium chloride solution, is then filtered, is cleaned using cleaning, drying to constant weight, so
Water chestnut skin is crushed afterwards, obtains water chestnut skin powder, dandelion powder is impregnated into 30min at 40 DEG C using citric acid solution, is then passed through
Filtering is cleaned using cleaning, and drying to constant weight, then crushes dandelion, obtains dandelion powder, and water chestnut skin powder and Pu is public
English powder is uniformly mixed by 3:1 mass ratio, obtains mixed-powder, and mixed-powder is mixed with ethanol solution by 1:6 mass ratio
Afterwards, it is stirred 2 hours at 60 DEG C, is then filtered, obtains filtrate and filter residue, filter residue is repeated to extract 1 time, merging is filtered twice
It is dry to get water chestnut skin and dandelion extract to be carried out rotary evaporation by liquid for combined filtrate.
3. a kind of wet tissue special suitable for patients with rhinitis as claimed in claim 2, which is characterized in that the sodium chloride solution
Mass fraction is Ei 0.26%, and the citric acid solution mass fraction is 0.55%.
4. a kind of wet tissue special suitable for patients with rhinitis as claimed in claim 2, which is characterized in that the water chestnut skin powder
Degree is 100 mesh, and the dandelion Powder Particle Size is 80 mesh.
5. a kind of wet tissue special suitable for patients with rhinitis as claimed in claim 2, which is characterized in that the ethanol solution matter
Measuring score is 78%.
6. a kind of wet tissue special suitable for patients with rhinitis as described in claim 1, which is characterized in that the flower bud of lily magnolia and humulus grass
Composite extract the preparation method comprises the following steps:
(1) flower bud of lily magnolia and humulus grass are respectively crushed into powder, obtain flower bud of lily magnolia powder and humulus grass powder, flower bud of lily magnolia powder and humulus grass powder are pressed into 1:1.2
Mass ratio is uniformly admixed together, obtains mixed-powder；
(2) grifola frondosus species suspension is mixed into progress fermented and cultured by 1:10 mass ratio with culture medium, obtains grifola frondosus
Mycelium fermentation broth is stirred 2 hours maitake mushroom mycelia fermentation liquid with 3500r/min revolving speed, obtains treatment fluid；
(3) after mixed-powder being mixed with the sodium hydroxide solution that concentration is 0.8mol/L by 1:5 mass ratio, at 80 DEG C,
15min is impregnated under 0.5MPa pressure, is then filtered again, is cleaned using clear water to neutrality, naturally dry, and it is mixed to obtain alkali process
Close powder；
(4) alkali process mixed-powder obtained above and treatment fluid obtained above are mixed in 100-105g:220mL ratio,
It is placed 20 hours at 35 DEG C, obtains fermentation treatment fluid, add the ethyl alcohol of its quality 70%, into fermentation treatment fluid with 2000r/
Min revolving speed stirs 2 hours, is then filtered, obtains filtrate, carries out steam sterilizing to filtrate, then carries out to filtrate reverse osmosis
Processing removes macromolecular substances, dry to get the flower bud of lily magnolia and humulus grass composite extract then carrying out rotary evaporation again.
7. a kind of wet tissue special suitable for patients with rhinitis as claimed in claim 6, which is characterized in that step (1) described ash
Setting flower species suspension grifola frondosus strain concentration is 1 × 105cfu/mL。
8. a kind of wet tissue special suitable for patients with rhinitis as claimed in claim 6, which is characterized in that step (1) described hair
Ferment culture is to cultivate 2 days at 40 DEG C.
9. a kind of wet tissue special suitable for patients with rhinitis as described in claim 1, which is characterized in that step (1) described training
Feeding base is made of following component by weight: glucose 1.5, magnesium sulfate 0.09, zinc chloride 0.06, potassium dihydrogen phosphate 0.15,
Sodium dihydrogen phosphate 0.13, pure water 100.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811067449.4A CN109010209A (en) | 2018-09-13 | 2018-09-13 | A kind of wet tissue special suitable for patients with rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811067449.4A CN109010209A (en) | 2018-09-13 | 2018-09-13 | A kind of wet tissue special suitable for patients with rhinitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109010209A true CN109010209A (en) | 2018-12-18 |
Family
ID=64622091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811067449.4A Withdrawn CN109010209A (en) | 2018-09-13 | 2018-09-13 | A kind of wet tissue special suitable for patients with rhinitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010209A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336676A (en) * | 2020-11-20 | 2021-02-09 | 山东中特新能源有限公司 | Special non-irritant sterilization and disinfection rhinitis wet tissue based on photocatalysis principle and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755361A (en) * | 2011-04-28 | 2012-10-31 | 辽宁盛京制药有限公司 | Moist towelette for preventing and curing rhinitis and preparation method for moist towelette |
| CN105434200A (en) * | 2014-08-22 | 2016-03-30 | 天津市有为印刷包装有限公司 | Nose-protecting wet tissue and preparation method thereof |
| CN106344751A (en) * | 2016-08-25 | 2017-01-25 | 旌德县万方日用品有限公司 | Cleaning type wet tissue capable of preventing and treating rhinitis |
| CN107629965A (en) * | 2017-09-25 | 2018-01-26 | 云南中医学院 | A kind of preparation method of dendrobium candidum fungi fermentation product and its fermented product and application |
| CN107811279A (en) * | 2017-09-25 | 2018-03-20 | 云南中医学院 | A kind of method of medical edible fungal fermentation green peel of walnut and its fermented product and application |
-
2018
- 2018-09-13 CN CN201811067449.4A patent/CN109010209A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755361A (en) * | 2011-04-28 | 2012-10-31 | 辽宁盛京制药有限公司 | Moist towelette for preventing and curing rhinitis and preparation method for moist towelette |
| CN105434200A (en) * | 2014-08-22 | 2016-03-30 | 天津市有为印刷包装有限公司 | Nose-protecting wet tissue and preparation method thereof |
| CN106344751A (en) * | 2016-08-25 | 2017-01-25 | 旌德县万方日用品有限公司 | Cleaning type wet tissue capable of preventing and treating rhinitis |
| CN107629965A (en) * | 2017-09-25 | 2018-01-26 | 云南中医学院 | A kind of preparation method of dendrobium candidum fungi fermentation product and its fermented product and application |
| CN107811279A (en) * | 2017-09-25 | 2018-03-20 | 云南中医学院 | A kind of method of medical edible fungal fermentation green peel of walnut and its fermented product and application |
Non-Patent Citations (3)
| Title |
|---|
| 刘有缘编著: "《三味中药治大病》", 31 January 2015, 山西科学技术出版社 * |
| 旷惠桃，潘远根，柳景红主编: "《中医本草疗法 珍藏本》", 31 January 2009 * |
| 黄煌等主编: "《名中医方药传真》", 31 July 2018, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336676A (en) * | 2020-11-20 | 2021-02-09 | 山东中特新能源有限公司 | Special non-irritant sterilization and disinfection rhinitis wet tissue based on photocatalysis principle and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104224633B (en) | A kind of pure tree peony heal-care essential oil and preparation method thereof | |
| CN102807921A (en) | Method for preparing cypress essential oil by combining water vapor distillation with supercritical CO2 extraction | |
| CN101822373A (en) | Golden-fungus gingko functional food, preparation method and use thereof | |
| CN105193876A (en) | Purslane extract and preparation method thereof | |
| CN104845903B (en) | The lactobacillus plantarum of thermophilic Radix Glycyrrhizae and its Radix Glycyrrhizae probiotics preparation of preparation | |
| CN113564212A (en) | Method for extracting eucommia ulmoides leaf polysaccharide by using microbial fermentation method | |
| CN114209617A (en) | Yeast fermented ganoderma lucidum extract and preparation method and application thereof | |
| CN104451927B (en) | A kind of Chinese medicine expelling parasite additive and application thereof | |
| CN108685798A (en) | A kind of moist moisturizer of baby | |
| CN109010209A (en) | A kind of wet tissue special suitable for patients with rhinitis | |
| CN110201043A (en) | A kind of olibanum composite essential oil and application | |
| CN105596780A (en) | Dendrobium candidum healthcare wine and production method thereof | |
| CN105412530A (en) | Traditional Chinese medicine extract with bacteriostasis, scrap removing and itch relieving function and preparation method and application thereof | |
| CN110477368B (en) | High-activity cordyceps sinensis powder and preparation method and application thereof | |
| CN106317236A (en) | Method for increasing astragalus polysaccharides by using fermentation technology | |
| CN105111323B (en) | A kind of method for extraction and purification of the black nightshade refined polysaccharide with antitumor activity | |
| CN100344719C (en) | Method for producing linen glue | |
| CN105943572A (en) | Chinese chestnut flower ethyl acetate extract and preparation method and application thereof | |
| CN108567914A (en) | It is a kind of that there is the Chinese medicine preparation and its preparation method and application for improving sleep effect | |
| CN104055701B (en) | Anti-allergy conditioning shampoo | |
| CN107375332A (en) | Amniotic epithelial cells and amnion mesenchymal stem cell mixture are preparing the application in treating diabetes medicament | |
| CN104027397B (en) | A kind of preparation method of integration of edible and medicinal herbs plant extract anti-sensitizer and application | |
| CN102755266A (en) | Chinese herbal medicine extract, preparation method thereof, and application thereof | |
| CN105853787A (en) | Alkaline plant salt capable of decreasing blood sugar and preparation method thereof | |
| CN108852888A (en) | A kind of mild non-stimulated shower cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181218 |
|
| WW01 | Invention patent application withdrawn after publication |