CN108992657A - 一种治疗胆汁反流性胃炎的中药制剂和制备方法 - Google Patents
一种治疗胆汁反流性胃炎的中药制剂和制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗胆汁反流性胃炎的中药制剂及其制备方法,其原料组成包括:香附、莪术、土茯苓、党参、蒲公英、薏苡仁、白术、柴胡、川楝子、炮姜、赤芍、栀子、甘草、白芍、郁金、枳实、白花蛇舌草、黄连、黄芪、金钱草。本发明的有益效果是中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,适用于肝胃不和型胆汁反流性胃炎患者,疗效最佳,肝胆湿热、脾胃虚弱型患者疗效较好;本发明中药制剂治疗胆汁反流性胃炎疗效确切,且可明显提高患者血浆胃动素水平,减轻临床症状,提高患者生活质量,值得临床广泛推广应用。
Description
技术领域
本发明属于中药制剂领域,尤其涉及一种治疗胆汁反流性胃炎的中药制剂和制备方法。
背景技术
胆汁反流性胃炎亦称碱性反流性胃炎,是指由幽门括约肌功能失调或胃幽门手术等原因造成含有胆汁、胰液等十二指肠内容物流入胃,使胃黏膜产生炎症、糜烂和出血等,减弱胃黏膜屏障功能,引起H+弥散增加,而导致胃黏膜慢性炎症。胆汁反流性胃炎的病因主要为胃大部切除、胃空肠吻合术后,以及幽门功能失常和慢性胆道疾病,细菌(尤其是幽门螺杆菌)感染、胃酸、胆汁等损害胃黏膜造成炎症,增加胃泌素释放,影响胃十二指肠动力,导致胃-幽门-十二指肠协调运动失调,引起十二指肠逆蠕动增加、幽门关闭功能减弱、胃排空延迟,使得十二指肠内容物过量反流入胃;任何导致胃肠动力的紊乱,如胃肠神经肽和激素水平异常可使胃肠道运动紊乱,解剖异常的因素,如原发性幽门括约肌功能障碍可使幽门开放时间延长、幽门松弛或持续开放状态,均可发生病理性十二指肠胃反流。临床表现:一、腹胀:是比较主要的症状之一,表现为腹部饱胀不适,中上腹持续烧灼感,也可表现为胸骨后痛,餐后可加重;二、胃灼热:胃部有灼烧感,甚至有些患者食管也会有烧灼感,常常伴有嗳气、反酸、恶心、呕吐、肠鸣、排便不畅、食欲减退以及消瘦等现象;三、胃出血:重的胆汁反流性胃炎患者还会出现胃出血的情况,有的患者大便呈现黑色,有的是呕血;四、呕吐:由于胃排空障碍,呕吐一般发生在晚间或半夜,有些患者呕吐物中带血。现有技术中,治疗该病的手段为:
1.药物治疗:(1)胃动力药物:能增加胃肠道蠕动,抑制胆汁反流入胃,促进反流物排空。常用的有:多潘立酮(吗叮啉)、莫沙必利(新络纳)等。(2)胃黏膜保护剂种类较多,主要作用包括能与胃黏膜的黏蛋白结合形成保护膜,以减轻反流的胆汁和胃酸对胃黏膜的刺激,加强消化道黏膜屏障的作用,有利于胃黏膜的再生,促使胃黏膜分泌黏液,从而保护胃黏膜,促进炎症愈合作用。(3)结合胆盐类药物:①达喜(铝碳酸镁),通过与胆酸和溶血磷脂酰胆碱结合,继而减轻胆盐对胃黏膜的损伤,对胆汁反流性胃炎效果明显,为临床上主要用药;②阴离子交换树脂(考来烯胺),口服后释放出氯离子,与胆酸结合,形成不可溶、不吸收的复合物,加速胆盐及粪便排出,减少胃黏膜损害。(4)抑制胃酸药:胃酸和胆汁有叠加的作用,对胃黏膜的损伤作用强,抑酸药对胆汁反流同样有效。①H2受体阻断剂(H2RA):西咪替丁、雷尼替丁、法莫替丁;②质子泵抑制剂(PPI):奥美拉唑、兰索拉唑、雷贝拉唑泮、托拉唑、及埃索美拉唑,抑酸作用远优于H2受体阻断剂。(5)根治幽门螺杆菌感染:胆汁反流性胃炎可与幽门螺杆菌感染并存,在常规应用抑酸剂、胃黏膜保护剂和胃动力药物治疗的同时,应首先考虑根除幽门螺杆菌。不但有利于病变愈合,更可减少诱发癌变的几率。
2.手术治疗:主要适用于症状严重内科治疗无效者,常用术式有Roux-en-Y手术或胆道分流术。
3.饮食调养:饮食要清淡,不吃油腻食物,以免刺激胆汁分泌增多,加重反流和病情。应细嚼慢咽,忌暴饮暴食。避免饮酽茶、烈酒、浓咖啡和进食辛辣、过冷、过热和粗糙食物。
4.去除某些加重病情的因素:包括戒烟酒、避免精神紧张,保持心情舒畅,不服或慎服对胃黏膜有刺激的药物。
缺点是,目前对该病采取的主要手段使西药治疗,但西药治疗大多是暂时控制病情,而且服用某一类西药对人体有害无益,人体免疫功能减退,致使病情反复难愈。
发明内容
本发明所要解决的技术问题,提供一种治疗胆汁反流性胃炎的中药制剂和制备方法,所选药材配伍相宜,符合中医药学和现代医药学理论,治疗胆汁反流性胃炎疗效确切,且可明显提高患者血浆胃动素(MLT)水平,减轻临床症状,提高患者生活质量,值得临床广泛推广应用。
为实现上述目的,本发明采用如下技术方案:
一种治疗胆汁反流性胃炎的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:香附8-13份、莪术13-18份、土茯苓13-18份、党参13-18份、蒲公英28-35份、薏苡仁28-35份、白术13-18份、柴胡5-7份、川楝子8-13份、炮姜2.5-4份、赤芍8-13份、栀子6-8份、甘草2.5-4份、白芍8-13份、郁金8-13份、枳实13-18份、白花蛇舌草17-22份、黄连3-7份、黄芪28-35份、金钱草28-35份。
一种治疗胆汁反流性胃炎的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:香附9-11份、莪术14-17份、土茯苓14-17份、党参14-17份、蒲公英28-30份、薏苡仁29-32份、白术14-17份、柴胡6-7份、川楝子9-11份、炮姜3-4份、赤芍9-11份、栀子6-7.5份、甘草3-4份、白芍9-11份、郁金9-11份、枳实14-17份、白花蛇舌草19-22份、黄连4-6份、黄芪28-33份、金钱草28-33份。
一种治疗胆汁反流性胃炎的中药制剂,制成所述中药制剂有效成分的原料组成及重量份数为:香附10份、莪术15份、土茯苓15份、党参15份、蒲公英30份、薏苡仁30份、白术15份、柴胡6份、川楝子10份、炮姜3份、赤芍10份、栀子7.份、甘草3份、白芍10份、郁金10份、枳实1份、白花蛇舌草20份、黄连5份、黄芪30份、金钱草30份。
一种治疗胆汁反流性胃炎的中药制剂的制备方法,其特点是包括如下步骤:
(1)按原料重量份数称取,加8倍量水,煎煮3次,每次1.5小时,合并煎液,浓缩至药液与药材的比例为1:2,即每毫升药液含2g生药;
(2)加乙醇至含醇量达80%,醇沉8小时以上,抽滤,滤液回收乙醇,得浸膏;
(3)将上述浸膏70℃浓缩至相对密度约1.30,减压干燥,粉碎80~100目;
(4)加入2%的阿司帕坦,再加糊精至总量,混匀,用40%~50%乙醇作润湿剂,制粒,干燥,整粒,10g/袋分装,即得。
本发明中各中药成份的药理分析如下:
香附,中药名。为莎草科植物莎草CyperusrotundusL.的干燥根茎。具有疏肝解郁,调经止痛,理气调中的功效。主治肝郁气滞胁痛、腹痛,月经不调,痛经,乳房胀痛,气滞腹痛。
莪术,中药名。姜黄属多年生宿根草本。主治治心腹胀痛,癥瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛。
土茯苓,中药名。为百合科植物光叶菝葜SmilaxglabraRoxb.的干燥块茎。具有解毒,除湿,通利关节功效。主治杨梅毒疮,肢体拘挛,淋浊带下,湿疹瘙痒,痈肿疮毒。
党参,中药名。为桔梗科植物党参Codonopsis pilosula(Franch.)Nannf.、素花党参(西党参)Codonopsis pilosula Nannf.var.modesta(Nannf.)L.T.Shen或川党参Codonopsis tangshen Oliv.的干燥根。治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。现代药理研究,党参可显著降低胃液、胃酸分泌和胃蛋白酶活性,有抗溃疡、抗胃粘膜损伤的作用,对胃肠运动亦有一定的影响。
蒲公英,中药名。为菊科植物蒲公英TaraxacummongolicumHand.-Mazz.、碱地蒲公英T.sinicumKitag.或同属数种植物的干燥全草。具有清热解毒,消肿散结,利湿通淋功效。主治痈肿疔毒,乳痈内痈,热淋涩痛,湿热黄疸,清肝明目。
薏苡仁,中药名。为禾本科植物薏苡的干燥成熟种仁。秋季果实成熟时采割植株,晒干,打下果实,再晒干,除去外壳、黄褐色种皮和杂质,收集种仁。主治水肿,脚气,小便不利,脾虚泄泻,湿痹拘挛,肺痈,肠痈;赘疣,癌肿。
白术,中药名。属于菊科、苍术属多年生草本植物。喜凉爽气候,以根茎入药。主治脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。
柴胡,中药名。为伞形科植物柴胡BupleurumchinensieDC.或狭叶柴胡BupleurumscorzonerifoliumWilld.的干燥根。具有解表退热,疏肝解郁,升举阳气功效。主治表证发热,少阳证,肝郁气滞,气虚下陷,脏器脱垂,退热截疟。
川楝子,中药名。为楝科植物川楝MeliatoosendanSieb.etZucc.的干燥成熟果实。具有疏肝泄热,行气止痛,杀虫的功效。主治脘腹胁助疼痛,疝气疼痛,虫积腹痛,头癣。
炮姜,中药名。为姜科植物姜ZingiberofficinaleRose.干燥根茎的炮制品。具有温经止血,温中止痛的功效。主治出血证,腹痛,腹泻。
赤芍,中药名。为毛茛科植物赤芍或川赤芍的干燥根。具有清热凉血,活血祛瘀的功效。主治温毒发斑,血热吐衄,目赤肿痛,痈肿疮疡,肝郁胁痛,经闭痛经,癥瘕腹痛,跌打损伤。
栀子,中药名。为茜草科植物栀子的干燥成熟果实。具有泻火除烦,清热利湿,凉血解毒功效。主治热病心烦,湿热黄疸,血淋涩痛,血热吐衄,目赤肿痛,火毒疮疡。
甘草,中药名。为豆科植物甘草Glycyrrhiza uralensis Fisch.、胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabra L.的干燥根。主治脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
白芍,中药名。为毛茛科植物芍药Paeonia lactiflora Pall.的干燥根。主治治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。宜:血虚阴虚之人胸腹胁肋疼痛,肝区痛,胆囊炎胆结石疼痛者宜食;泻痢腹痛,妇女行经腹痛者宜食。
郁金,中药名。为姜科植物温郁金Curcuma wenyujin Y.H.Chen et C.Ling、姜黄Curcuma longa L.、广西莪术Curcuma kwangsiensis S.G.Lee et C.F.Liang或蓬莪术Curcuma phaeocaulis Val.的干燥块根。主治治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。
枳实,中药名。为芸香科植物酸橙CitrusaurantiumL.及其栽培变种或甜橙CitrussinensisOsbeck的干燥幼果。具有破气消积,化痰除痞的功效。主治胃肠积滞,湿热泻痢,胸痹,结胸,气滞胸胁疼痛,产后腹痛。
白花蛇舌草,中药名。为茜草科耳草属植物白花蛇舌草的全草。具有清热解毒,利湿通淋功效。主治痈肿疮毒,咽喉肿痛,毒蛇咬伤,热淋涩痛。
黄连,中药名。为毛莨科植物黄连CoptischinensisFranch.、三角叶黄连CoptisdeltoideaC.Y.etHsiao或云连CoptisteetaWall.的干燥根茎。具有清热燥湿,泻火解毒功效。主治湿热痞满,呕吐吞酸,湿热泻痢,高热神昏,心烦不寐,血热吐衄,痈肿疖疮,目赤牙痛,消渴,外治湿疹、湿疮、耳道流脓。
黄芪,中药名。为豆科植物蒙古黄芪Astragalus membranaceus(Fisch.)Bge.var.mongholicus(Bge.)Hsiao或膜荚黄芪Astragalus membranaceus(Fisch.)Bge.的干燥根。补气固表,利尿托毒,排脓,敛疮生肌。主治气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,痈疽难溃,久溃不敛,血虚痿黄,内热消渴;慢性肾炎蛋白尿,糖尿病。
金钱草,中药名。为报舂花科植物过路黄的全草或带根全草。主治清热,利湿,消肿,解毒。治黄疸,水肿,胆结石、肾结石、膀胱结石,反胃噎膈,跌打损伤,疔疮肿毒。
阿司帕坦,药用辅料,为天门冬酰苯丙氨酸甲酯,白色结晶性粉末。甜味,其甜度相当于蔗糖的170倍。
糊精,作药片粘合剂,可快速干燥,快速散开,快速粘合及再湿可溶。
方解:全方为肝郁脾胃气滞疏泻不畅,胆汁反流诸症而设。方中香附辛平,主入肝、脾气分,为疏肝解郁行气止痛之要药;枳实辛苦温,主入脾胃,破气消痞,散结导滞;两者合用以行肝、脾、胃之气同为君药。辅以川楝子苦寒降泄,清肝火、泄郁热、行气止痛。柴胡疏肝解郁,并能升脾胃清阳之气,与君药同用,则舒肝行气止痛之力更彰。莪术破血中之气,又能活血祛瘀,赤芍清热凉血兼活血化瘀止痛,两者共奏活血解痉之功。党参、黄芪、白术、白芍之属甘温善补中气,益脾胃以资运化而使升降复常。蒲公英、金钱草、土茯苓清热解毒、散结消肿利湿。以上诸药补行并举,寒温同用,既能补中益气,又行气活血止痛,兼能清热解毒利湿,助主药针对肝脾郁结之主证,故同为臣药。黄连苦寒,炮姜辛热,辛苦并用,散降结合,效能调寒热,散痞结以襄调气之功;郁金、栀子凉血活血散结偏助莪、芍;薏苡仁善能渗除脾湿、健脾补中;白花蛇舌草清热解毒消肿效佳,诸药共为佐药。甘草和中缓急,调和诸药是为使药。本方数药合用,有行有补,照顾全面,达到既行气泄热又活血祛湿止痛的作用。
本发明的有益效果是:中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,适用于肝胃不和型胆汁反流性胃炎患者,疗效最佳,肝胆湿热、脾胃虚弱型患者疗效较好;本发明中药制剂治疗胆汁反流性胃炎疗效确切,且可明显提高患者血浆胃动素水平,减轻临床症状,提高患者生活质量,值得临床广泛推广应用。
具体实施方式
下面结合具体实施例对本发明做进一步说明。
实施例1
治疗胆汁反流性胃炎中药组合物,各原料的重量份是:
香附10g、莪术15g、土茯苓15g、党参15g、蒲公英30g、薏苡仁30g、白术15g、柴胡6g、川楝子10g、炮姜3g、赤芍10g、栀子7.5g、甘草3g、白芍10g、郁金10g、枳实15g、白花蛇舌草20g、黄连5g、黄芪30g、金钱草30g。
(1)按原料重量份数称取,加8倍量水,煎煮3次,每次1.5小时,合并煎液,浓缩至药液与药材的比例为1:2,即每毫升药液含2g生药;
(2)加乙醇至含醇量达80%,醇沉8小时以上,抽滤,滤液回收乙醇,得浸膏;
(3)将上述浸膏70℃浓缩至相对密度约1.30,减压干燥,粉碎80~100目;
(4)加入2%的阿司帕坦,再加糊精至总量,混匀,用40%~50%乙醇作润湿剂,制粒,干燥,整粒,10g/袋分装,即得。
用于治疗胆汁反流性胃炎,口服,早晚各一次。
实施例2
治疗胆汁反流性胃炎中药组合物,各原料的重量份是:
香附12g、莪术17g、土茯苓17g、党参17g、蒲公英35g、薏苡仁35g、白术16g、柴胡6g、川楝子12g、炮姜3.5g、赤芍12g、栀子8g、甘草3.5g、白芍12g、郁金12g、枳实17g、白花蛇舌草22g、黄连6g、黄芪35g、金钱草32g。
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
用于治疗胆汁反流性胃炎,口服,早晚各一次。
实施例3
治疗胆汁反流性胃炎中药组合物,各原料的重量份是:
香附7g、莪术13g、土茯苓13g、党参13g、蒲公英29g、薏苡仁29g、白术14g、柴胡5g、川楝子7g、炮姜2.5g、赤芍7g、栀子6.5g、甘草4g、白芍7g、郁金7g、枳实13g、白花蛇舌草18g、黄连4g、黄芪29g、金钱草20g。
本实施例的中药制剂制备方法工艺步骤及用法用量与实施例1相同。
用于治疗胆汁反流性胃炎,口服,早晚各一次。
临床资料
1.一般资料
发明人于2015年8月-2017年5月间共收治110例胆汁反流性胃炎的门诊患者,其中男63例,女47例;年龄21-75岁,病程0.5-12年。在年龄、病情等资料无显著性差异的情况下,随机分为观察组70例,对照组40例。
2.试验方法
2.1对照组,采用常规西医治疗。
2.2观察组,在对照组采用常规西医治疗的基础上,加用本申请实施例1制得中药制剂,早晚各一次,每次1袋,连续服药30天为1周期,治疗3个周期。
3.疗效标准与治疗结果
3.1疗效标准
在胆汁反流性胃炎的临床治疗中,中医临床疗效标准参照《中医消化病诊疗指南》拟定、胃镜检查疗效评定标准参照《慢性胃炎中西医结合诊断和疗效标准》拟定。临床疗效根据《中药新药临床研究指导原则》拟定,主要观察脘腹胀满、胃脘灼痛、嗳气、反酸、恶心、呕苦等十项临床症状,疗效评定标准:治愈:症状体征完全消失,胃镜复查活动性炎症及胆汁反流消失,6个月内未见复发;显效:主要临床症状体征消失,胃镜复查活动性炎症好转,胆汁反流改善,6个月内虽有复发,但程度减轻,持续时间缩短;无效:临床症状无改善,胃镜复查胆汁反流无改变,治疗前后无变化。
3.2治疗结果
治疗统计结果见下表
组别 | n | 痊愈 | 显效 | 无效 | 总有效率 |
对照组 | 40 | 8 | 15 | 17 | 57.50% |
观察组 | 70 | 33 | 29 | 8 | 88.57% |
治疗组总有效率88.57%,明显高于对照组,能够安全有效治疗胆汁反流性胃炎;在进一步病理研究中发现,本发明中药制剂特别适用于肝胃不和型胆汁反流性胃炎,疗效最佳;肝胆湿热、脾胃虚弱型患者疗效较好,淤血阻络型患者疗效一般。因此本发明中药制剂治疗胆汁反流性胃炎疗效确切,且可明显提高患者血浆胃动素(MLT)水平,减轻临床症状,提高患者生活质量。
Claims (4)
1.一种治疗胆汁反流性胃炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:香附8-13份、莪术13-18份、土茯苓13-18份、党参13-18份、蒲公英28-35份、薏苡仁28-35份、白术13-18份、柴胡5-7份、川楝子8-13份、炮姜2.5-4份、赤芍8-13份、栀子6-8份、甘草2.5-4份、白芍8-13份、郁金8-13份、枳实13-18份、白花蛇舌草17-22份、黄连3-7份、黄芪28-35份、金钱草28-35份。
2.根据权利要求1所述一种治疗胆汁反流性胃炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:香附9-11份、莪术14-17份、土茯苓14-17份、党参14-17份、蒲公英28-30份、薏苡仁29-32份、白术14-17份、柴胡6-7份、川楝子9-11份、炮姜3-4份、赤芍9-11份、栀子6-7.5份、甘草3-4份、白芍9-11份、郁金9-11份、枳实14-17份、白花蛇舌草19-22份、黄连4-6份、黄芪28-33份、金钱草28-33份。
3.根据权利要求1所述一种治疗胆汁反流性胃炎的中药制剂,其特征在于:制成所述中药制剂有效成分的原料组成及重量份数为:香附10份、莪术15份、土茯苓15份、党参15份、蒲公英30份、薏苡仁30份、白术15份、柴胡6份、川楝子10份、炮姜3份、赤芍10份、栀子7.份、甘草3份、白芍10份、郁金10份、枳实1份、白花蛇舌草20份、黄连5份、黄芪30份、金钱草30份。
4.一种如权利要求1-3任一项所述治疗胆汁反流性胃炎的中药制剂的制备方法,其特征在于:包括以下工艺步骤:
(1)按原料重量份数称取,加8倍量水,煎煮3次,每次1.5小时,合并煎液,浓缩至药液与药材的比例为1:2,即每毫升药液含2g生药;
(2)加乙醇至含醇量达80%,醇沉8小时以上,抽滤,滤液回收乙醇,得浸膏;
(3)将上述浸膏70℃浓缩至相对密度约1.30,减压干燥,粉碎80~100目;
(4)加入2%的阿司帕坦,再加糊精至总量,混匀,用40%~50%乙醇作润湿剂,制粒,干燥,整粒,10g/袋分装,即得。
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Title |
---|
关志宇: "《药物制剂辅料与包装材料》", 31 January 2017, 中国医药科技出版社 * |
张国华: "《胃炎灵冲剂治疗胆汁返流性胃炎138例》", 《实用中医内科杂志》 * |
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