CN113368059A - 一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法 - Google Patents

一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法 Download PDF

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CN113368059A
CN113368059A CN202110759752.6A CN202110759752A CN113368059A CN 113368059 A CN113368059 A CN 113368059A CN 202110759752 A CN202110759752 A CN 202110759752A CN 113368059 A CN113368059 A CN 113368059A
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王晓兵
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Abstract

本发明公开了一种治疗幽门螺旋杆菌肝胃不合的中药干粉，所述合剂由以下重量份的原料药制成：柴胡10、香附10、陈皮12、枳壳12、白芍15、木香6、川穹10、生甘草6、厚朴6、川楝子15、延胡索10、青皮6、苏梗6、丹皮6、栀子6、黄连10、蒲公英30。本发明的各原料配伍合理，立法周全，用药周到，具有益气健脾、提气固本、养阴生津、消积行气、滋阴清热、养阴益胃、抑菌、幽门堵塞之功效，可解毒、抗菌、防癌、修复溃疡，解除反酸、嗳气、幽门堵塞等幽门螺杆菌感染症状，进而可有效控制和根治幽门螺旋杆菌感染，对肝胃不合出现的胃脘、胁肋胀满疼痛，嗳气、呃逆、吞酸，情绪抑郁，不欲食，苔薄黄，脉弦有较好的疗效。

Description

一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法
技术领域
本发明涉及中药技术领域，尤其涉及一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法。
背景技术
幽门螺杆菌感染的症状：（1）主要是反酸、烧心以及胃痛、口臭。这主要是由于幽门螺杆菌诱发胃泌素疯狂分泌，而发生发酸烧心，而具有胃溃疡疾病的患者，幽门螺杆菌更是引起了主要症状胃痛的发生，口臭最直接的病菌之一就是幽门螺杆菌了。（2）幽门螺旋杆菌能够引起慢性胃炎。所发生的主要临床表现有：上腹部不适、隐痛，有时发生嗳气、反酸、恶心、呕吐的症状，病程较为缓慢，但是容易反复发作。（3）患者感染幽门螺杆菌后产生多种致病因子，从而引起胃黏膜损害，临床疾病的发生呈现多样性，而且患者多会出现反酸、嗳气、饱胀感等等，均是感染幽门螺杆菌的患者比没有感染幽门螺杆菌的患者多数倍。（4）幽门螺杆菌感染一般有时没有特别明显的症状，这时一般是通过检查来判断有无幽门螺杆菌感染的，幽门螺杆菌这种致病菌，很容易诱发胃肠疾病的发生。
肝胃不合是肝气瘀滞，横逆犯胃，胃失和降，以胃脘、胁肋胀满疼痛，嗳气、呃逆、吞酸，情绪抑郁，不欲食，苔薄黄，脉弦等为常见症的证候。包括肝气犯胃和肝胃郁热。
目前幽门螺旋杆菌阳性和肝胃不合的治疗通常都是服用抗菌素，经常服用抗菌素还会伤胃。对此，发明人对此进行了大量的研究以及参考大量病例，研制出一种能够根除幽门螺旋杆菌和肝胃不合的中药。
发明内容
本发明目的就是为了弥补已有技术的缺陷，提供一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法。
本发明是通过以下技术方案实现的：
一种治疗幽门螺旋杆菌肝胃不合的中药干粉，所述合剂由以下重量份的原料药制成：
柴胡8-15、香附8-15、陈皮10-15、枳壳10-15、白芍10-20、木香3-9、川穹8-15、生甘草3-9、厚朴3-9、川楝子10-20、延胡索8-15、青皮3-9、苏梗3-9、丹皮3-9、栀子3-9、黄连8-15、蒲公英25-35。
所述合剂由以下重量份的原料药制成：
柴胡10、香附10、陈皮12、枳壳12、白芍15、木香6、川穹10、生甘草6、厚朴6、川楝子15、延胡索10、青皮6、苏梗6、丹皮6、栀子6、黄连10、蒲公英30。
一种治疗幽门螺旋杆菌肝胃不合的中药干粉的制备方法，具体包括以下步骤：
（1）将蒲公英和川楝子混合进行低温超微粉碎，得300目以上的混合超微粉；
（2）将柴胡、香附、陈皮、枳壳混合加6-10倍量水煮提2-3次，每次1-2h，取药液离心,浓缩,加酸调PH=2.0，保温沉淀，分别用热水和含水乙醇洗沉淀，低温干燥，得混合提取物；
（3）将白芍、木香、川穹、生甘草混合加30-50%乙醇溶液6-10倍量,加热回流提取2-3次，每次1-2h，合并回流液，滤过，减压回收乙醇，得混合浓缩液二，药渣备用；
（4）厚朴、川楝子、青皮、苏梗、丹皮、栀子、黄连与步骤（3）的药渣混合加水6-10倍量，煎煮2-3次，每次1-2h合并煎煮液，离心，减压浓缩，得混合浓缩液三；
（5）合并步骤（1）（2）（3）（4）所得物，喷雾干燥，得中药干粉。
本发明所用中药中：
柴胡是常用解表药。性味苦、微寒，归肝、胆经。有和解表里，疏肝升阳之功效。用于感冒发热、寒热往来、疟疾、肝郁气滞、胸肋胀痛、脱肛、子宫脱垂、月经不调。
香附辛、微苦、微甘，平。归肝、脾、三焦经。疏肝解郁，理气宽中，调经止痛。用于肝郁气滞，胸胁胀痛，疝气疼痛，乳房胀痛，脾胃气滞，脘腹痞闷，胀满疼痛，月经不调，经闭痛经。
陈皮味苦、辛，性温。归肺、脾经。理气健脾，燥湿化痰。用于脘腹胀满，食少吐泻，咳嗽痰多。
枳壳具有理气宽中，行滞消胀之功效。常用于胸胁气滞，胀满疼痛，食积不化，痰饮内停，脏器下垂。
白芍具有养血调经，敛阴止汗，柔肝止痛，平抑肝阳之功效。常用于血虚萎黄，月经不调，自汗，盗汗，胁痛，腹痛，四肢挛痛，头痛眩晕。
木香辛、苦，温。归脾、胃、大肠、三焦、胆经。行气止痛，健脾消食。用于胸胁、脘腹胀痛，泻痢后重，食积不消，不思饮食。煨木香实肠止泻。用于泄泻腹痛。
川穹辛，温。归肝、胆、心包经 ，活血行气，祛风止痛。用于胸痹心痛，胸胁刺痛，跌扑肿痛，月经不调，经闭痛经，症瘕腹痛，头痛，风湿痹痛。
生甘草益气补中；缓急止痛；润肺止咳；泻火解毒；调和诸药。主倦怠食少；肌瘦面黄；心悸气短；腹痛便溏；四肢挛急疼痛；脏躁；咳嗽气喘；咽喉肿痛；痈疮肿痛；小儿胎毒；及药物、食物中毒。
厚朴归脾、胃、肺、大肠经。燥湿消痰，下气除满。用于湿滞伤中，脘痞吐泻，食积气滞，腹胀便秘，痰饮喘咳。
川楝子归肝、小肠、膀胱经。疏肝泄热，行气止痛，杀虫。用于肝郁化火，胸胁、脘腹胀痛，疝气疼痛，虫积腹痛。
延胡索辛、苦，温。归肝、脾经。活血，行气，止痛。用于胸胁、脘腹疼痛，胸痹心痛，经闭痛经，产后瘀阻，跌扑肿痛。
青皮味苦、辛，性温。归肝、胆、胃经。有疏肝破气，消积化滞的功效。用于胸胁胀痛，疝气疼痛，乳癖，乳痈，食积气滞，脘腹胀痛。
苏梗理气宽中，止痛，安胎。用于胸膈痞闷，胃脘疼痛，嗳气呕吐，胎动不安。
丹皮，为芍药科植物牡丹干燥根皮。秋季采挖根部，除去细根，剥取根皮，晒干。生用或炒用。现代研究，所含牡丹酚及其以外的糖苷类成分均有抗炎作用；牡丹皮的甲醇提取物有抑制血小板作用；牡丹酚有镇静、降温、解热、镇痛、解痉等中枢抑制作用及抗动脉粥样硬化、利尿、抗溃疡等作用。
栀子具有护肝、利胆、降压、镇静、止血、消肿等作用。常用于治疗黄疸型肝炎、扭挫伤 、高血压、糖尿病等症。
黄连归心、脾、胃、肝、胆、大肠经。清热燥湿，泻火解毒。主治湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，心悸不宁，血热吐衄，目赤，牙痛，消渴，痈肿疗疮；外治湿疹，湿疮，耳道流脓。
蒲公英清热解毒、消痈散结、健胃愈疡，因为现在研究发现蒲公英有很好的健胃利胆效果、抗溃疡的效果，所以对于慢性胃炎、胃溃疡，还有幽门螺杆菌感染，都有一定的疗效；湿通淋，用于湿热黄疸或者尿路感染、尿路结石引起的小便赤热、涩痛，有一定的疗效。蒲公英还有一定的清肝明目的功效，用于肝火上炎引起的目赤肿痛。
本发明的优点是：本发明的各原料配伍合理，立法周全，用药周到，具有疏肝理气、和胃止痛、益气健脾、提气固本、养阴生津、消积行气、滋阴清热、养阴益胃、抑菌、幽门堵塞之功效，可解毒、抗菌、防癌、修复溃疡，解除反酸、嗳气、幽门堵塞等幽门螺杆菌感染症状，进而可有效控制和根治幽门螺旋杆菌感染，对肝胃不合出现的胃脘、胁肋胀满疼痛，嗳气、呃逆、吞酸，情绪抑郁，不欲食，苔薄黄，脉弦有较好的疗效。
具体实施方式
一种治疗幽门螺旋杆菌肝胃不合的中药干粉，所述合剂由以下重量份的原料药制成：
柴胡10、香附10、陈皮12、枳壳12、白芍15、木香6、川穹10、生甘草6、厚朴6、川楝子15、延胡索10、青皮6、苏梗6、丹皮6、栀子6、黄连10、蒲公英30。
一种治疗幽门螺旋杆菌肝胃不合的中药干粉的制备方法，具体包括以下步骤：
（1）将蒲公英和川楝子混合进行低温超微粉碎，得300目以上的混合超微粉；
（2）将柴胡、香附、陈皮、枳壳混合加6-10倍量水煮提2-3次，每次1-2h，取药液离心,浓缩,加酸调PH=2.0，保温沉淀，分别用热水和含水乙醇洗沉淀，低温干燥，得混合提取物；
（3）将白芍、木香、川穹、生甘草混合加30-50%乙醇溶液6-10倍量,加热回流提取2-3次，每次1-2h，合并回流液，滤过，减压回收乙醇，得混合浓缩液二，药渣备用；
（4）厚朴、川楝子、青皮、苏梗、丹皮、栀子、黄连与步骤（3）的药渣混合加水6-10倍量，煎煮2-3次，每次1-2h合并煎煮液，离心，减压浓缩，得混合浓缩液三；
（5）合并步骤（1）（2）（3）（4）所得物，喷雾干燥，得中药干粉。
典型病例1：闫某，男，50岁，经常反酸、烧心以及胃痛、口臭，医院就诊后，幽门螺旋杆菌检测结果：阳性+Dpm68；服用本发明中药合剂，一天三次，一次1袋，服药一个疗程后，上述症状减轻，继续服药2个疗程，症状全部消失，复查Hp（-）。
典型病例2：向某，40岁，男，上腹部不适、隐痛，有时发生反酸、恶心、呕吐的症状，医院就诊， C=102阳性Hp（+）。服用本发明中药合剂，一天三次，一次1袋，服药一个疗程后，上述症状减轻，复查，C=60，阳性Hp（+），继续服药2个疗程，症状全部消失，复查Hp（-）。
典型病例3：罗某，女，45岁，自述症状为腹胀满疼痛，嗳气、呃逆、吞酸，情绪抑郁，食欲不振，苔薄黄，医生诊断为肝胃不合，服用本发明中药合剂，一天三次，一次1袋，服药一个疗程后，上述症状减轻，服药两个疗程后，症状全部小时，不再复发。

Claims (3)

1.一种治疗幽门螺旋杆菌肝胃不合的中药干粉，其特征在于：所述合剂由以下重量份的原料药制成：
柴胡8-15、香附8-15、陈皮10-15、枳壳10-15、白芍10-20、木香3-9、川穹8-15、生甘草3-9、厚朴3-9、川楝子10-20、延胡索8-15、青皮3-9、苏梗3-9、丹皮3-9、栀子3-9、黄连8-15、蒲公英25-35。
2.根据权利要求1所述的一种治疗幽门螺旋杆菌肝胃不合的中药干粉，其特征在于：所述合剂由以下重量份的原料药制成：
柴胡10、香附10、陈皮12、枳壳12、白芍15、木香6、川穹10、生甘草6、厚朴6、川楝子15、延胡索10、青皮6、苏梗6、丹皮6、栀子6、黄连10、蒲公英30。
3.一种治疗幽门螺旋杆菌肝胃不合的中药干粉的制备方法，其特征在于：具体包括以下步骤：
（1）将蒲公英和川楝子混合进行低温超微粉碎，得300目以上的混合超微粉；
（2）将柴胡、香附、陈皮、枳壳混合加6-10倍量水煮提2-3次，每次1-2h，取药液离心,浓缩,加酸调PH=2.0，保温沉淀，分别用热水和含水乙醇洗沉淀，低温干燥，得混合提取物；
（3）将白芍、木香、川穹、生甘草混合加30-50%乙醇溶液6-10倍量,加热回流提取2-3次，每次1-2h，合并回流液，滤过，减压回收乙醇，得混合浓缩液二，药渣备用；
（4）厚朴、川楝子、青皮、苏梗、丹皮、栀子、黄连与步骤（3）的药渣混合加水6-10倍量，煎煮2-3次，每次1-2h合并煎煮液，离心，减压浓缩，得混合浓缩液三；
（5）合并步骤（1）（2）（3）（4）所得物，喷雾干燥，得中药干粉。
CN202110759752.6A 2021-07-06 2021-07-06 一种治疗幽门螺旋杆菌肝胃不合的中药干粉及其制备方法 Withdrawn CN113368059A (zh)

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