CN108969598A - A kind of combination of Chinese tradiational and Western medicine drug that treating hyperplastic anemia and preparation method - Google Patents
A kind of combination of Chinese tradiational and Western medicine drug that treating hyperplastic anemia and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia and preparation methods, it is just extracted by Western medicine using Chinese medicine, it is prepared into tablet, capsule or granule, the ingredient including following parts by weight: 14-15 parts of fructus lycii, 9-10 parts of dried human placenta, 8-10 parts of Radix Angelicae Sinensis, 8-10 parts of Radix Codonopsis, 5-6 parts of cordyceps sinensis, 5-6 parts of Radix Polygalae, 11-12 parts of Caulis Spatholobi, 6-8 parts of jujube.Each Chinese medicine material of the present invention passes through reasonable compatibility, and drug effect complements each other, and drug effect is significant, has preferably improved the inside function of human body, by the inherent cause of disease of anaemia, human body is improved in all directions, achievees the purpose that treating both manifestation and root cause of disease.It can solve prior art western medicines in treatment and be cured that rate is low, problem easy to recur, convenient to take, cost is relatively low, without side-effects.
Description
Technical field
The present invention relates to Traditional chinese medicine medicament technical field, specially a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia and
Preparation method.
Background technique
Hyperplastic anemia cause for some reason hematoclasis accelerate or generate reduce and cause peripheral red blood cells or
Referred to as anaemia when hemoglobin is lowly normal.Hyperplastic anemia is the synthesis title that one group of disease causes anaemia, it presses cell
Form is classified, and marrow performance has certain general character, but the morphology description that cannot only rely on bone marrow cell carries out really
The one group of disease examined.Hyperplastic anemia includes following disease: hypoferric anemia, hemolytic anemia, acute posthemorrhagic anemia and
Anaemia caused by rheumatic fever, endocrine disturbance, hypovitaminosis etc..
According to the theory of traditional Chinese medicine, source and the generation of blood depend on the function of taste and kidney, at present clinically
There are many drugs for treating anaemia, and Chinese medicine has blood treasured, complex prescription glue mucilage etc., the anemia cause of disease specific aim that these drugs are treated
It is single, and it is unhappy to work, and curative effect is low, and the state of an illness easily repeatedly, is not easy to eradicate.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia and preparation
Method, said preparation have effects that quick, good effect, it is convenient to take, without side-effects, do not rebound.
It is an object of the present invention to provide a kind of combination of Chinese tradiational and Western medicine drugs for treating hyperplastic anemia, using Chinese medicine
It is just extracted by Western medicine, is prepared into tablet, capsule or granule, the ingredient including following parts by weight: 13-15 parts of fructus lycii,
8-10 parts of dried human placenta, 7-10 parts of Radix Angelicae Sinensis, 6-10 parts of Radix Codonopsis, 4-6 parts of cordyceps sinensis, 4-6 parts of Radix Polygalae, 10-12 parts of Caulis Spatholobi, jujube
5-8 parts.
Further, the ingredient including following parts by weight: 14-15 parts of fructus lycii, 9-10 parts of dried human placenta, 8-10 parts of Radix Angelicae Sinensis,
8-10 parts of Radix Codonopsis, 5-6 parts of cordyceps sinensis, 5-6 parts of Radix Polygalae, 11-12 parts of Caulis Spatholobi, 6-8 parts of jujube.
Further, the ingredient including following parts by weight: 15 parts of fructus lycii, 10 parts of dried human placenta, 10 parts of Radix Angelicae Sinensis, Radix Codonopsis 10
Part, 5 parts of cordyceps sinensis, 5 parts of Radix Polygalae, 12 parts of Caulis Spatholobi, 7 parts of jujube.
Fructus lycii: sweet and neutral；Return liver and kidney channel.Major function: nourishing liver and kidney, benefiting shrewd head.For consumption consumptive loss, waist and knee acid
Bitterly, dizziness and tinnitus, impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.Contain 14 kinds of amino acid in fructus lycii, and contains
The special nutrient compositions such as glycine betaine, zeaxanthin, physalin and carrotene abundant, multivitamin and calcium, iron
Deng.
Dried human placenta: nature and flavor: Gan Xian, temperature.Channel tropism: enter lung, the heart, kidney channel.Effect: tonifying Qi, blood-nourishing, strengthening the essence.The major functions: deficient,
Win the diseases such as thin, hemoptysis asthma, the hot hectic fever due to yin of labor, spermatorrhea.
Radix Angelicae Sinensis: replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, menostasis pain
Through, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Codonopsis: sweet and neutral.Bowl spares, QI invigorating are promoted the production of body fluid.Weakness of the spleen and the stomach, qi-blood deficiency is controlled, the tired inability of body, deficiency of food is thirsty, long
It rushes down, rectal prolapse.
Cordyceps sinensis: sweet and neutral.Kidney tonifying benefit lung, hemostasis and phlegm.Impotence and seminal emission is cured mainly, soreness of waist and knee joint: this product tonifying kidney and benefiting sperm,
There is the function of activating the phlegm.With controlling the insufficiency of the kidney yang, impotence and seminal emission, the soreness of waist and knee joint of blood and essence asthenia.Chronic cough and dyspnea of deficiency type, overstrain cough phlegm blood: this
Product are sweet flat, and function kidney tonifying benefit lung, hemostasis and phlegm, relieving cough and asthma for the good merchantable brand of flat tonifying lung kidney, especially overstrain cough phlegm blood is multi-purpose.
Radix Polygalae: for conventional Chinese medicine, being recorded in Shennong's Herbal earliest, is classified as top grade, and is considered as supporting life key medicine, source
In the dry root of milk wort Radix Polygalae and ovum leaf Radix Polygalae.It is warm-natured, it is bitter, pungent, have the function of tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence,
Despicable for insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, amnesia and pavor, expectoration is not well, sore swollen toxin, breast swell and pain.
Caulis Spatholobi: bitter, sweet, warm.Return liver and kidney channel.It enriches blood, invigorates blood circulation, dredging collateral.For irregular menstruation, blood deficiency chlorosis, numb paralysis
Paralysis, rheumatic arthralgia.
Jujube: sweet, warm.Returns spleen, stomach meridian.Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.For spleen eating less, loose stool out of strength, married woman is dirty
It is hot-tempered.
A kind of preparation method of above-mentioned combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, includes the following steps:
Step 1: Chinese medicine fructus lycii, Radix Angelicae Sinensis, Radix Codonopsis, Caulis Spatholobi, jujube being mixed in proportion and are put into container, is added 5~8
The distilled water of amount again, heating are boiled 2~3 hours, are extracted, and filtering obtains filtrate, are heated and are concentrated into paste, are put into 70 DEG C of baking oven bakings
It is cooling after dry, it is ground into fine powder, it is spare；
Step 2: Chinese medicine dried human placenta, cordyceps sinensis and Radix Polygalae are put into container, pulverization process is carried out, is ground into fine powder,
It is spare；
Step 3: fine powder obtained by above-mentioned steps 1 and step 2 being put into micronizer, is ground into 0.1~10 μm
Mixed powder of the micron particles and partial size of volume average particle size less than the nano-scale particle composition of 0.1 μm of volume average particle size
Material, it is spare；
Step 4: being added in the mixed powder that above-mentioned steps 3 are obtained relative to 3~5 times of quality of the mixed powder
The ethyl alcohol that determining alcohol is 60%~70%, stirring and dissolving obtains ethanol solution, and ethanol solution is quiet under conditions of 5 DEG C~10 DEG C
It sets 24~36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate are concentrated and dried, and
It is put into micronizer and crushes 30~50 minutes herein, obtain the micron particles and grain of 0.1~10 μm of volume average particle size
Diameter is spare less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms；
Step 5: tablet, capsule or granule is made in particle made from step 4.
The beneficial effects of the present invention are:
A kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia of the present invention, each Chinese medicine material pass through reasonable compatibility, fill
The distinctive performance of each raw material itself and effect, the complementation between having taken into account are waved in distribution, and drug effect complements each other, drug effect
Significantly, the inside function for preferably having improved human body, by the inherent cause of disease of anaemia, human body is improved in all directions, is reached
To the purpose for the treatment of both manifestation and root cause of disease.It can solve prior art western medicines in treatment and be cured that rate is low, problem easy to recur, and pair nontoxic to the human body
Effect, convenient to take, good absorption effect, cost is relatively low, without side-effects.
Specific embodiment
Below in conjunction with the specific embodiment of the invention, technical solution of the present invention is clearly and completely described, is shown
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
A kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, using Chinese medicine just by Western medicine extract, be prepared into tablet,
Capsule or granule, the ingredient including following parts by weight: 13 parts of fructus lycii, 8 parts of dried human placenta, 7 parts of Radix Angelicae Sinensis, 6 parts of Radix Codonopsis, winter worm
Summer grass 4 parts, 4 parts of Radix Polygalae, 10 parts of Caulis Spatholobi, 5 parts of jujube.
A kind of preparation method of above-mentioned combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, includes the following steps:
Step 1: Chinese medicine fructus lycii, Radix Angelicae Sinensis, Radix Codonopsis, Caulis Spatholobi, jujube being mixed in proportion and are put into container, is added 5 times
The distilled water of amount, heating are boiled 2 hours, are extracted, and filtering obtains filtrate, and heating is concentrated into paste, are put into cold after 70 DEG C of baking oven drying
But, it is ground into fine powder, it is spare；
Step 2: Chinese medicine dried human placenta, cordyceps sinensis and Radix Polygalae are put into container, pulverization process is carried out, is ground into fine powder,
It is spare；
Step 3: fine powder obtained by above-mentioned steps 1 and step 2 being put into micronizer, 0.1 μm of volume is ground into
The micron particles and partial size of average grain diameter are standby less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms
With；
Step 4: 3 times of quality of the alcohol relative to the mixed powder being added in the mixed powder that above-mentioned steps 3 are obtained
The ethyl alcohol that concentration is 60%~70%, stirring and dissolving obtain ethanol solution, ethanol solution are stood 24 hours under the conditions of 5 DEG C,
Using percolation with the speed of 1ml per minute, slowly diacolation, collection percolate are concentrated and dried, and be put into ultramicro grinding herein
It is crushed 30 minutes in machine, the micron particles and partial size for obtaining 0.1 μm of volume average particle size are less than 0.1 μm of volume average particle size
The mixed powder of nano-scale particle composition, it is spare；
Step 5: tablet is made in particle made from step 4.
Embodiment 2
A kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, using Chinese medicine just by Western medicine extract, be prepared into tablet,
Capsule or granule, the ingredient including following parts by weight: 15 parts of fructus lycii, 10 parts of dried human placenta, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis,
6 parts of cordyceps sinensis, 6 parts of Radix Polygalae, 12 parts of Caulis Spatholobi, 8 parts of jujube.
A kind of preparation method of above-mentioned combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, includes the following steps:
Step 1: Chinese medicine fructus lycii, Radix Angelicae Sinensis, Radix Codonopsis, Caulis Spatholobi, jujube being mixed in proportion and are put into container, is added 6 times
The distilled water of amount, heating are boiled 2.5 hours, are extracted, filtering, obtain filtrate, and heating is concentrated into paste, after being put into 70 DEG C of baking oven drying
It is cooling, it is ground into fine powder, it is spare；
Step 2: Chinese medicine dried human placenta, cordyceps sinensis and Radix Polygalae are put into container, pulverization process is carried out, is ground into fine powder,
It is spare；
Step 3: fine powder obtained by above-mentioned steps 1 and step 2 being put into micronizer, it is flat to be ground into 3 μm of volumes
The micron particles and partial size of equal partial size are spare less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms；
Step 4: 4 times of quality of the alcohol relative to the mixed powder being added in the mixed powder that above-mentioned steps 3 are obtained
The ethyl alcohol that concentration is 60%~70%, stirring and dissolving obtain ethanol solution, it is small that ethanol solution are stood to 30 under conditions of 8 DEG C
When, using percolation with the speed of 2ml per minute, slowly diacolation, collection percolate are concentrated and dried, and be put into Ultramicro-powder herein
It is crushed 40 minutes in broken machine, the micron particles and partial size for obtaining 4 μm of volume average particle sizes are less than 0.1 μm of volume average particle size
The mixed powder of nano-scale particle composition, it is spare；
Step 5: granule is made in particle made from step 4.
Embodiment 3
A kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, using Chinese medicine just by Western medicine extract, be prepared into tablet,
Capsule or granule, the ingredient including following parts by weight: 15 parts of fructus lycii, 10 parts of dried human placenta, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis,
5 parts of cordyceps sinensis, 5 parts of Radix Polygalae, 12 parts of Caulis Spatholobi, 7 parts of jujube.
A kind of preparation method of above-mentioned combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, includes the following steps:
Step 1: Chinese medicine fructus lycii, Radix Angelicae Sinensis, Radix Codonopsis, Caulis Spatholobi, jujube being mixed in proportion and are put into container, is added 7 times
The distilled water of amount, heating are boiled 3 hours, are extracted, and filtering obtains filtrate, and heating is concentrated into paste, are put into cold after 70 DEG C of baking oven drying
But, it is ground into fine powder, it is spare；
Step 2: Chinese medicine dried human placenta, cordyceps sinensis and Radix Polygalae are put into container, pulverization process is carried out, is ground into fine powder,
It is spare；
Step 3: fine powder obtained by above-mentioned steps 1 and step 2 being put into micronizer, it is flat to be ground into 10 μm of volumes
The micron particles and partial size of equal partial size are spare less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms；
Step 4: 5 times of quality of the alcohol relative to the mixed powder being added in the mixed powder that above-mentioned steps 3 are obtained
The ethyl alcohol that concentration is 60%~70%, stirring and dissolving obtain ethanol solution, it is small that ethanol solution are stood to 36 under conditions of 10 DEG C
When, using percolation with the speed of 2ml per minute, slowly diacolation, collection percolate are concentrated and dried, and be put into Ultramicro-powder herein
It is crushed 40 minutes in broken machine, obtains less than 0.1 μm volume average particle size of micron particles and partial size of 10 μm of volume average particle sizes
Nano-scale particle composition mixed powder, it is spare；
Step 5: capsule is made in particle made from step 4.
Embodiment 4
Application method: oral, 2 times a day, each 1 time sooner or later, 4 tablets once for tablet (every 0.6g), and granule one wraps every time
(every packet 2.5g), capsule 4 tablets each time (every 0.6g), warm water delivery service；8 days are 1 course for the treatment of, and 2~4 courses for the treatment of can fully recover from an illness
More, serious patient increases the amount of discretion.
Embodiment 5
Toxicity test:
1, acute toxicity test:
(1) mouse 40 are chosen, half male and half female, 25~34g of weight carries out acute toxicity test.Mouse is randomly divided into two
Group, i.e. experimental group and control group, fasting 12 hours before testing；
(2) 1 is taken to be dissolved in 10ml water in combination of Chinese tradiational and Western medicine preparation of the invention, it is spare；
(3) take with step (2) same amount of normal saline, it is spare；
(4) the perfusion amount pair that the combination of Chinese tradiational and Western medicine preparation solution of the present invention in step (2) is 5ml/kg by stomach-filling volume is taken
20 mouse of experimental group carry out perfusion；It is administered 2 times within one day, delivery time 6 hours, is observed continuously after administration 14 days, and
Record the toxic reaction and death toll of mouse；
(5) 20 by the perfusion amount that stomach-filling volume is 5ml/kg to control group of same amount of normal saline in step (3) are taken
Mouse carries out perfusion；It is administered 2 times within one day, delivery time 6 hours, is observed continuously after administration 14 days, and record the poison of mouse
Property reaction and death toll；
The results showed that compared with the control group, mouse has no notable difference after experimental group administration, experiment is observed continuously 14
It, mouse systemic situation, diet, drinking-water, body weight increase are normal.
2, long term toxicity test:
Mouse 40 are chosen, half male and half female, 25~34g of weight carries out long term toxicity test.By traditional Chinese and western medicine knot of the invention
Closing preparation takes 1 to be dissolved in 10ml water, carries out perfusion to mouse by the perfusion amount that stomach-filling volume is 5ml/kg, 2 times a day, even
It is discontinued 3 weeks after continuous medication 15 weeks, carries out Germicidal efficacy.
The results showed that combination of Chinese tradiational and Western medicine preparation of the present invention is to the hair of mouse, behavior, stool and urine, weight, internal organs weight
The indexs such as amount, blood picture, hepatic and renal function, blood glucose, blood lipid all have no significant effect, and internal organs naked eyes are without finding abnormal variation, histology
Inspection result shows that also nothing is substantially change Organs of Mice；Illustrate combination of Chinese tradiational and Western medicine preparation of the present invention to mouse long-term administration
Small toxicity afterwards, also without abnormal reaction after drug withdrawal, application is safe.
Embodiment 6
Typical case citing:
Liu, male, 42 years old, Enterprise Staff.With hypoferric anemia, medicament for enriching blood is repeatedly taken, symptom, which has no, obviously to be changed
It is kind.The oral solution for taking Chinese materia medica preparation of the present invention is treated, and after taking six courses for the treatment of, Anemia is cured, and follow-up is not
See recurrence.
Zhao, female, 34 years old.Patient suffers from acute posthemorrhagic anemia, malnutritive, takes Chinese materia medica preparation of the present invention and is controlled
It treats, after seven course of therapy, is checked to hospital, blood picture index restores normal.
Wei, male, 27 years old, student.Excessive blood loss after patient's wound takes Chinese medicine system of the present invention by there is Anemia
Agent is treated, and after seven course of therapy, patient feels strong from head to foot, checks through hospital, and blood picture restores normal.
Wu, female, 38 years old, civil servant.Suffering from endocrine disturbance leads to anaemia, take the oral solution of Chinese materia medica preparation of the present invention into
Row treatment, after taking eight courses for the treatment of, anemia symptom disappears, and on inspection, blood picture is normal.
The above comparative experiments can be seen that the present invention for the curative effect highly significant for the treatment of treatment hyperplastic anemia.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia, which is characterized in that just extracted by Western medicine using Chinese medicine, system
It is standby at tablet, capsule or granule, 13-15 parts of the ingredient fructus lycii including following parts by weight, 8-10 parts of dried human placenta, Radix Angelicae Sinensis 7-
10 parts, 6-10 parts of Radix Codonopsis, 4-6 parts of cordyceps sinensis, 4-6 parts of Radix Polygalae, 10-12 parts of Caulis Spatholobi, 5-8 parts of jujube.
2. a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia according to claim 1, which is characterized in that including with
The ingredient of lower parts by weight: 14-15 parts of fructus lycii, 9-10 parts of dried human placenta, 8-10 parts of Radix Angelicae Sinensis, 8-10 parts of Radix Codonopsis, cordyceps sinensis 5-6
Part, 5-6 parts of Radix Polygalae, 11-12 parts of Caulis Spatholobi, 6-8 parts of jujube.
3. a kind of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia according to claim 1, which is characterized in that including with
The ingredient of lower parts by weight: 15 parts of fructus lycii, 10 parts of dried human placenta, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis, 5 parts of cordyceps sinensis, 5 parts of Radix Polygalae, chicken
12 parts of blood rattan, 7 parts of jujube.
4. a kind of preparation method of combination of Chinese tradiational and Western medicine drug for treating hyperplastic anemia according to claim 1, feature
It is, includes the following steps:
Step 1: Chinese medicine fructus lycii, Radix Angelicae Sinensis, Radix Codonopsis, Caulis Spatholobi, jujube being mixed in proportion and are put into container, 5~8 times of amounts are added
Distilled water, heating boils 2~3 hours, extracts, and filtering obtains filtrate, and heating is concentrated into paste, after being put into 70 DEG C of baking oven drying
It is cooling, it is ground into fine powder, it is spare；
Step 2: Chinese medicine dried human placenta, cordyceps sinensis and Radix Polygalae are put into container, pulverization process is carried out, is ground into fine powder, it is spare；
Step 3: fine powder obtained by above-mentioned steps 1 and step 2 being put into micronizer, 0.1~10 μm of volume is ground into
The micron particles and partial size of average grain diameter are standby less than the mixed powder that the nano-scale particle of 0.1 μm of volume average particle size forms
With；
Step 4: being added in the mixed powder that above-mentioned steps 3 are obtained pure and strong relative to 3~5 times of quality of the mixed powder
The ethyl alcohol that degree is 60%~70%, stirring and dissolving obtain ethanol solution, ethanol solution are stood 24 under conditions of 5 DEG C~10 DEG C
~36 hours, using percolation with the speed of 1~2ml per minute, slowly diacolation, collection percolate were concentrated and dried, and herein
It is put into micronizer and crushes 30~50 minutes, micron particles and the partial size for obtaining 0.1~10 μm of volume average particle size are small
It is spare in the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size；
Step 5: tablet, capsule or granule is made in particle made from step 4.
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