CN1089605C - Capsule for treatment of leukoderma - Google Patents

Abstract

The present invention relates to a capsule for treating leukoderma, which is used for treating leukoderma, namely a commonly seen and frequently encountered disease in a department of dermatology. The present invention is characterized in that the prescription of the capsule comprises 18% to 30% of astragalus root, 0.3% to 5% of american ginseng, 15% to 25% of angelica, 12% to 25% of red sage root, 5% to 15% of saffron, 18% to 30% of, tribulus terrestris, 8% to 24% of prepared rhizome of rehmannia, 4% to 12% of cortex moutan, 4% to 12% of pulp of dogwood fruit, 4% to 12% of Chinese yam, 3% to 9% of PORIA from Yunnan of China, 3% to 9% of water plantain, 15% to 25% of dodder seed, 0.8% to 6% of aweto, 12% to 20% of psoralea fruit, 15% to 30% of coix seed, 15% to 30% of mulberry leaf and 2.3% to 6% of cassia twig. The present invention has the advantages of reasonable mixing, obvious therapeutic effect, soft effect and little side effect; besides, primary ingredients and secondary ingredients are obvious in the prescription; the present invention is convenient to take and carry.

Description

A kind of treatment vitiligo capsule

The therapy of vitiligo that the present invention relates to the dermatology common disease frequently-occurring disease is with a kind of treatment vitiligo capsule

Present therapy for vitiligo for the dermatology common disease frequently-occurring disease, obtained very big progress in recent years, but for remaining on the therapy for vitiligo: 1, corticosteroid hormone treatment vitiligo in some problems, both oral administration, external, local injection, certain effect is all arranged, the side effect of external can be controlled, and rebound phenomenon appears in the patient but have partly after the drug withdrawal for oral administration, and white macula enlarges on the contrary.2, the use of immunomodulator such as levamisole, transfer factors etc. can improve cellular immune function, and the treatment vitiligo also has partly curative effect, but side effect is big, and the patient takes medicine, and the back is dizzy, uncomfortable, the granulocytopenia of intestines and stomach, and What is more causes hepatorenal damage.3, the home-made vifiligo pill of Chinese patent medicine, capsule, granule etc., the patient does not feel any better by explanation clothes year white macula half a year to two.4, the pigment cell who speaks of cultivation transplants, and still is among the research at present.

Because have these problems, curative effect is oversize the undesirable course of treatment, 1 year, 2 years, taking medicine of ten spring and autumn had an injection from three to five years, the state of an illness was not felt any better.

The purpose of this invention is to provide a kind of to vitiligo respond well to treatment soon, curative effect is obvious, side effect is little, the medicine of taking convenience.

The medicine of technical solution of the present invention and prescription thereof are to utilize on the basis of the capsular raw material of preparation of the prior art, and each composition and the percentage by weight thereof of its prescription are:

Radix Astragali 18-30%, Radix Panacis Quinquefolii 0.3-5%, Radix Angelicae Sinensis 15-25%, Radix Salviae Miltiorrhizae 12-25%, Stigma Croci 5-15%, Fructus Atriplicis Sibiricae 18-30%, Radix Rehmanniae Preparata 8-24%, Cortex Moutan 4-12%, Fructus Corni 4-12%, Rhizoma Dioscoreae 4-12%, Poria 3-9%, Rhizoma Alismatis 3-9% Semen Cuscutae 15-25%, Cordyceps 0.8-6%, Fructus Psoraleae 12-20%, Semen Coicis 15-30%, Folium Mori 15-30%, Ramulus Cinnamomi 2.3-6%.

The Golden Mirror of Medicine vitiligo claims vitiligo again, and the cause of disease is a qi stagnation hemagglutination, and hot body, wind are invaded wetting phase and fought and cause qi-blood disharmony and white macula takes place in skin.

See it is that wind is invaded wetting phase and fought in skin from the leukodermic cause of disease, this explanation weakened defensive QI insufficiency of lung-QI, lung is the sea of gas, the kidney being the root of QI, the sun of spleen reinforcing kidney is defended heresy and can not be done with real, and the kidney invigorating is that treatment is leukodermic at all.It two is qi stagnation hemagglutinations, is the relation of the lung and the heart from pathogenesis.Belong to the relation that the part of the body cavity above the diaphragm housing the heart and lungs shows as QI and blood together, heart master blood, blood stored in the liver, The spleen governs the blood, qi as the commander of blood, blood being the material foundation of QI, the capable then blood of gas is capable, and the stagnation of QI is blood stasis then, takes based on blood circulation promoting and blood stasis dispelling, and benefiting qi and nourishing blood is auxilliary, the principles of formulating prescriptions that harmonizing yingfen and weifen makes for assistant.

See that from prescription medicine is broadly divided into four classes according to the rule of treatment:

One, the kidney invigorating method: nourishing the liver and kidney, to enrich blood based on liver, nourishing YIN is based on kidney, the sweet tonifying kidney-yin of Radix Rehmanniae Preparata is with strong kidney water in the side, and The liver and the kidney have a common source, belongs to the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels together, with kidney tonifying water, kidney is rushed down in the cloudy Rhizoma Alismatis eliminating dampness by diuresis of nutritious Chinese yam spleen with Fructus Corni tonifying liver the moon, the Cortex Moutan eliminating pathogen in the liver of relieving inflammation or internal heat, the light purgation of spleen excess that oozes of Poria, this is the moon of nourishing the liver and kidney, mends and oiliness, invigorating middle warmer has rushes down, benefit being arranged in rushing down, complement each other, is logical agent of mending folding.Cloudy positive helping and biochemical infinite helped medicine first-selection Semen Cuscutae, the Xin Ganping of the sun of spleen kidney, YANG invigorating tonifying YIN, the antidiarrheal that makes eye bright, sperm adding and marrow healthing removes lumbago and skelalgia, the arduous big temperature of Fructus Psoraleae, kidney invigorating and YANG supporting, warming spleen and stopping diarrha, Cordyceps, the supporing yang replenishing vital essence and blood of sweet temperature compensation kidney, tonifying YANG gas, this product can reinforcing kidney and strengthening resistance, can tonifying the lung defend in fact again, so the kidney invigorating is the leukodermic core of treatment.

Two, be qi stagnation hemagglutination from leukodermic etiology and pathogenesis, prescription is thrown the medicine of blood circulation promoting and blood stasis dispelling, cure the necessary blood circulation and channel invigorating of white macula, dispels the stasis of blood and stagnates, and Flos Carthami has very strong clots absorbing function, goes into Liver Channel, walks blood system, can declare promoting blood circulation.The Radix Salviae Miltiorrhizae function of promoting blood circulation to disperse blood clots is preferable, specially goes into blood system, and its merit is the promoting the circulation of blood of invigorating blood circulation, in reach internal organs and blood stasis dispelling stagnate outer profit joint and the network of promoting blood circulation, its property of medicine is cold and cool, can invigorate blood circulation and have the merit of removing heat from blood, the removing heat from blood that can clear away heart-fire, relieving restlessness is calmed the nerves, and the effect of slightly nourishing blood, Fructus Atriplicis Sibiricae is a medicine for calming liver and calming endopathic wind, goes into Liver Channel, and the effect of suppressing the hyperactive liver and subsiding YANG is arranged, the liver controlling conveyance and dispersion bar reaches, and stagnation of liver-QI is the catharsis malfunction then, so that depression and stagnation of QI, the band of gas is blood stasis then, has soothing the liver and effect Disperse hepatic depression, and soothing liver-QI for relieving depression is to help the power of Flos Carthami.

Three, leukodermic pathogenesis is qi-blood disharmony, so prescription medication recuperating the superficial defensive system benefiting qi and nourishing blood, Qi-tonifying drug often selects the sweet tepor of the Radix Astragali, invigorating QI to consolidate the body surface resistance, Radix Astragali focus on away table and reach skin, energy arresting sweating outward, consolidating superficial resistance, Radix Astragali Preparata focus on invigorating the spleen and replenishing QI energy spleen reinforcing hemopoietic, Radix Panacis Quinquefolii, bitter little sweet and cold, go into lung kidney two warps, can promote the production of body fluid by boosting qi and nourishing yin, again can clearing away lung-heat, the first-selected Radix Angelicae Sinensis of the medicine that nourishes blood, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot so can promoting the circulation of blood, invigorating middle warmer has, benefit is arranged, the gas medicine in the sincere blood, Ramulus Cinnamomi in the row, the treatment by benefiting qi and nourishing blood of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, harmonizing yingfen and weifen cause the harmonious YIN and YANG in a relative equilibrium spirit of leukodermic patient's QI and blood and even.

Four, the plain hot body of vitiligo patient, body has interior-heat, selects the sweet light invigorating spleen to remove dampness heat-clearing and toxic substances removing that is slightly cold of Semen Coicis, and Folium Mori bitter cold dispelling wind and heat pathogens a surname sending down the abnormal ascending QI machine is with the big temperature of system Fructus Psoraleae.

Prescription of the present invention not only has the function of blood circulation promoting and blood stasis dispelling, and can regulate the equilibrium between yin and yang of body internal organs meridian qi and blood, thus to liver-kidney yin deficiency, yang deficiency of spleen and stomache, qi stagnation and blood stasis type, QIXUELIANGXU type has curative effect preferably.

The present invention is used for clinical, observes according to 200 examples

Efficacy assessment standard:

1, recovery from illness: white macula all disappears or the colour of skin is similar to normal.

2, produce effects: white macula dwindles, and area is greater than 50%.

3, effective: there is the point-like melanin pigmentation at white macula center and edge, and the regeneration area accounts for 10%.

4, invalid: by treatment in 3-6 month, white macula district no change.

Therapeutic effect: in the middle of the 200 routine vitiligo patients, 81 examples of fully recovering account for 40.5%, and produce effects 55 examples account for 27.5%, and effective 53 examples account for 26.5%, and invalid 11 examples account for 5.5%, and total effective rate is 94.5%.

Model case:

Example 1, king *, the woman, Han nationality, the cadre, people from Xuanwu District, Beijing, go to a doctor October 25 nineteen ninety-five.

Main suit: find left eyelid leukoderma 3 years.

History of past illness: its elder brother has vitiligo.

Previously treat history: in Beijing * * hospital's combination therapy of Chinese and western 10 months, once obeyed decoction.

Check: the left eyelid leukoderma, comprise ULLE, left lower lid,eye, in adjoin portion, involving ophthalmic side eyebrow has 0.5CM approximately, eyebrow bleaches, involving nasion portion skin has 0.5CM approximately, left eyelid leukoderma area has 4.5 * 4.2CM approximately, right eyelid skin is normal.

Throw 1000 of Phaeolins, each 5, every day twice, taking medicine after meal, medication had erythematous response in 20 days, occur hair follicle melanin speckle after 66 days in the white macula, the inwardly expansion gradually of point-like melanin pigmentation appears in the white macula edge after 3 months, and spreads to the center, treatment by 1 year, white macula all disappears, and further consultation after 6 months is not sent out.

Example 2, Rhizoma Zingiberis Recens * *, the woman, 31 years old, Han nationality, Shanxi province Taiyuan city people, on May 6th, 95 went to a doctor.

The patient found white macula 2 years, and the left and right sides palm of the hand has 5, and as the white macula of 5 coin-dividing sizes, little itching has several white maculas approximately behind the ear collare, and sun in summer is shone back burning pain sense.

Family history: do not have similar disease, once used the methoxypsoralen 1 year of French import, psoralea tincture half a year, and oral Chinese medicine and western medicine 4 months, all invalidly come outpatient service.

Check: two white maculas of left hand carpel skin, be 1.2CM garden shape, behind the left ear skin 1.5 * 1.2CM white macula several, several white maculas of skin 2.1 * 1.0CM behind the left neck, 3 white maculas of right hand carpel skin, every is 1.2CM, garden shape.

Throw 1200 of Phaeolin capsules, each 5, every day 3 times, when taking medicine further consultation afterwards in 70 days, the patient says, took medicine 30 days, and felt very comfortable on one's body, take medicine and just found that white macula was rubescent in two months, find on inspection to occur in the white macula that hair follicle pigment point evacuates is distributed on the white macula, melanin merges in flakes mutually, and by 10 months treatment, white macula all disappeared, in December, 96 further consultation is not sent out.

Example 3, Hu Yong *, the man, 15 years old, people from Changli County, Hebei province, on June 25th, 1994 examined.

The main suit: find white patch on the face in May, 1989, as the Fructus Mori size.

Previously treat history: once surplus half a year in Beijing hospitalize, decoction, Chinese patent medicine, coating were all used 3 years, and be invalid.

Check, head, face, trunk, extremity skin, hair white, white macula accounts for more than 50% of body surface area.

Throw 2000 of Phaeolin capsules, each 10, twice of every day, taking medicine after meal, the further consultation over 90 days of taking medicine checks and finds that the melanin pigmentation in the white macula is star sieve mulberry shape and is distributed in head, facial, trunk, in the extremity skin and hair white macula, facial original white macula disappears, by 1 year 02 months treatment, white macula all disappeared.Once in November, 95, in December, 96 further consultation is not twice sent out.

Observe its curative effect from Phaeolin capsule for treating vitiligo clinical rehabilitation.

1, redden behind the patient's oral medicine more than erythematous response: the 75-80%, slight pain is arranged, this is the prelude that pigment point occurs, generally takes place in about 20-50 days in the back of taking medicine.

2, light-duty white macula, treatment by about 15-30 days, obvious in the white macula along pore appearance hair follicle pigmentation point in batch, calmness is put intensive or the evacuation point is distributed on the edge of white macula, then pigment point gradually by the edge to middle auxocardia, fusion is linked to be lamellar and recovery from illness gradually mutually, and light-duty recovery is fast, satisfactory effect.

3, heavy type: be meant that white macula accounts for more than 75% of body surface area, through one month treatment, its recovery was to occur a darker pigment zone earlier at the edge of white macula, move to the center, edge along pigment zone outwards enlarges gradually on the other hand, and white macula dwindles gradually, until recovery from illness.

The traditional Chinese medical science is thought leukodermic generation in a word, is qi-blood disharmony or strongly fragrant in skin by rheumatism by QI and blood deficiency, with the passing of time heat-transformation, thus benefiting qi and nourishing blood commonly used, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, nourishing the liver and kidney; The kidney person, the viscus with functions of reproduction and development, here skill goes out, and kidney governing bones is given birth to marrow, and store essential substances is colored as black at kidney, the true qualities of kidney of suffering from a deficiency of the kidney are solid, thus the generation white macula, yi and Kui are derived from the same origin, tonifying kidney-yin mainly is the moon of invigorating the liver and kidney, the medicine of nourishing YIN, often select Radix Rehmanniae Preparata for use, Rhizoma Dioscoreae, Fructus Corni, Poria, Rhizoma Alismatis, Cortex Moutan.YANG invigorating mainly is the sun of spleen reinforcing kidney, the medicine multiselect Semen Cuscutae of YANG invigorating, Cordyceps, Fructus Psoraleae etc., the sweet light invigorating spleen to remove dampness that is slightly cold of Semen Coicis, heat-clearing and toxic substances removing, Folium Mori bitter cold, dispelling wind and heat pathogens, a surname's sending down the abnormal ascending QI machine is with the big temperature of system Fructus Psoraleae, recuperating the superficial defensive system is often selected Ramulus Cinnamomi for use, and benefiting qi and nourishing yin is often selected the Radix Astragali, Radix Panacis Quinquefolii for use, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Atriplicis Sibiricae, Radix Angelicae Sinensis, blood circulation promoting and blood stasis dispelling, blood enriching and dryness moistening, profit is supported skin and all medicines match, thereby reaches the kidney invigorating, blood circulation promoting and blood stasis dispelling, the purpose of benefiting qi and nourishing blood, make people's QI and blood vigorous, make precise and tiny being failed of spleen be distributed in the vital organs of the human body, extremity hundred are complete, the defeated skin and hair that is distributed in is moistened fosterly, and white macula thereupon more.

Claims (2)

1, the leukodermic capsule of a kind of treatment is characterized in that the percentage by weight of each raw material is:

Radix Astragali 18-30%, Radix Panacis Quinquefolii 0.3-5%, Radix Angelicae Sinensis 15-25%, Radix Salviae Miltiorrhizae 12-25%, Stigma Croci 5-15%, Fructus Atriplicis Sibiricae 18-30%, Radix Rehmanniae Preparata 8-24%, Cortex Moutan 4-12%, Fructus Corni 4-12%, Rhizoma Dioscoreae 4-12%, Poria 3-9%, Rhizoma Alismatis 3-9% Semen Cuscutae 15-25%, Cordyceps 0.8-6%, Fructus Psoraleae 12-20%, Semen Coicis 15-30%, Folium Mori 15-30%, Ramulus Cinnamomi 2.3-6%.

2, a kind of treatment vitiligo capsule is that the percentage by weight of raw material is:

The Radix Astragali 28.5%, Radix Panacis Quinquefolii 0.38%, Radix Angelicae Sinensis 24.5%, Radix Salviae Miltiorrhizae 24.5%, Stigma Croci 14.8%, Fructus Atriplicis Sibiricae 28.8%, Radix Rehmanniae Preparata 8.8%, Cortex Moutan 4.8%, Fructus Corni 4.8%, Rhizoma Dioscoreae 4.8%, Poria 3.2%, Rhizoma Alismatis 3.2% Semen Cuscutae 24.5%, Cordyceps 3%, Fructus Psoraleae 18.9%, Semen Coicis 28.9%, Folium Mori 29.8%, Ramulus Cinnamomi 6%.