CN108938492A - It is a kind of to improve the compositions of skin lines, preparation method and applications - Google Patents
It is a kind of to improve the compositions of skin lines, preparation method and applications Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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Abstract
The present invention provides a kind of composition for improving skin lines, the components comprising following weight percentage: hyaluronic acid 0.1~8.0%；Trehalose 1.0~15.0%；Epithelical cell growth factor 0.1~8.0%；Gotu Kola P.E 1.0~5.0%；AA 2G 1.0~2.0%；Glutathione 0.5~5.0%；Glucan 3.0~10.0%；Cross-linking hyaluronic acid sodium 0.1~10.0% and Collagenase 0.1~8.0%.It is creative in the present composition to joined Collagenase and cross-linking hyaluronic acid sodium, skin lines can be effectively improved.And, the present invention also provides the preparation methods of the diversified forms products such as lotion, Essence, gel, creme, ointment, tincture, paint, film and patch (aqueous gel patch), not only simple process, it is easy to implement large-scale production, and can satisfy the diversification selection of different clients.Composition provided by the invention in use, can assist importing skin by beauty apparatus such as micropin, ultrasound, infrared, electric pulse, middle low frequencies, relative to being directly coated with, assimilation effect is more preferably.
Description
Technical field
The invention belongs to technique in skin care fields, and in particular to a kind of to improve the compositions of skin lines, preparation method
And its application.
Background technique
The loss of collagen existing for skin corium and elastin laminin matter will lead to skin elasticity and thickness as time goes by
The decline of degree preliminarily forms skin lines, and gradually leads to wrinkle of skin, relaxation and fold etc., seriously affects the beauty of women.
The method of common at present elimination or desalination microgroove includes: (1) essential oil champignon method, and the course for the treatment of of this method is longer, right
Champignon operation has certain technical requirements, and effect is also difficult to reach ideal degree, can just see through reparation in 1 year or more bright
Aobvious effect；(2) skin method to be changed, carries out changing skin by the method for physics or chemistry, the method is although quick, but wound is larger,
Sensitive skin quality is also easy to cause new scar, and easily causes adverse reaction using Chemopeel agent etc.；(3) laser is treated
Method, the method are not suitable for large area treatment, high to the technical requirements of laser operations, higher cost, and anaphase effect is undesirable；
(4) creams massage, the method promote the absorption of active constituent and the reparation of skin by using cosmetics combination with massaging is repaired,
Operate it is more convenient, it is without side-effects, be easy received by consumer, but repair cosmetics quality it is irregular, in the form of a single, portion
Divide reparation cosmetics that can only play conventional moisturizing and moisturizing effect, cannot achieve preferable repairing effect.
Patent CN107519036 discloses a kind of striae of pregnancy spray and preparation method thereof containing polypeptide, contains in said preparation
Polypeptide and active growth factor, repairing effect is preferable, but uses Sprayable, and dosage is larger, in the form of a single, expensive, system
Standby complex process.Although being had been favored by people using growth factor for treating aging skin, for more effective, diversified outer
Important and unsatisfied demand is still had with pharmaceutical formulation,
Therefore it provides a kind of safety is mild, control efficiency is good, it is various informative and it is lower-cost improve skin lines system
Agent will be able to satisfy the demand of the majority of consumers, have a vast market foreground.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of composition for improving skin lines, includes following weight percentage
The component of ratio: hyaluronic acid 0.1~8.0%；Trehalose 1.0~15.0%；Epithelical cell growth factor 0.1~8.0%；Accumulated snow
Careless extract 1.0~5.0%；AA 2G 1.0~2.0%；Glutathione 0.5~5.0%；Glucan 3.0
~10.0%；Cross-linking hyaluronic acid sodium 0.1~10.0%；Collagenase 0.1~8.0%.
Wherein, epithelical cell growth factor can promote various kinds of cell in epidermal cell and skin histology growth divide and
Metabolism promotes the synthesis and secretion of collagen, repairs the collagen elastomer of aging fracture, and then it is thin to reach reparation
The purpose of line, firm skin.AA 2G, is a kind of natural vitamin C, it contains glucose stable elements,
By the effect of enzyme and alpha-glucosidase on skin, vitamin C contained by AA 2G can be slowly stable
Come out, promote the collagen synthesis in fibroblast, and then achieve the purpose that improve microgroove and pachylosis.
Further, the composition form be lotion, Essence, gel, creme, ointment, tincture, paint, film and
The external preparation form well known in the art such as patch.
The present invention also provides a kind of preparation methods for improving skin lines Essence, include the following steps:
(1) it is anti-bad that hyaluronic acid, trehalose, epithelical cell growth factor, Gotu Kola P.E, L- are weighed respectively according to the ratio
Hematic acid 2- glucoside, glutathione, glucan, cross-linking hyaluronic acid sodium and Collagenase, addition weight percent are 5.0-
7.0% glycerol stirs 15~20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the water that weight percent is 25.0-86.0% is added, is stirred at 50~60r/min
Mix, until all components after mixing, be separately added into according to the ratio weight percent be 0.1~0.3% Chlorphenesin, 0.3
~0.5% Phenoxyethanol and 0.1~0.2% essence, stir 30~50min after, obtain mixture B；Wherein, 0.1~0.3%
Chlorphenesin, 0.3~0.5% Phenoxyethanol and 0.1~0.2% essence can also use preservative well known in the art and essence
System equivalent replaces.
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index after complying with standard, discharge, stand
With it is filling, obtain Essence.
Preferably, gained Essence in use, can directly be applied to skin surface, can also by micropin,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The present invention also provides a kind of preparation methods for improving skin lines gel, include the following steps:
(1) it is anti-bad that hyaluronic acid, trehalose, epithelical cell growth factor, Gotu Kola P.E, L- are weighed respectively according to the ratio
Hematic acid 2- glucoside, glutathione, glucan, cross-linking hyaluronic acid sodium and Collagenase, addition weight percent are 5.0-
7.0% glycerol stirs 15~20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the weight percent water for being 20.0~86.0% and the card for being 0.1~0.6% is added
Wave 940, after being uniformly dispersed, 50~60r/min stirring, until substantially uniformity mix, be subsequently added into weight percent be 0.1~
0.6% triethanolamine is separately added into the Chlorphenesin, 0.3 that weight percent is 0.1~0.3% after mixing evenly according to the ratio
~0.5% Phenoxyethanol and 0.1~0.2% essence, stir 30~50min after, obtain mixture B；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index after complying with standard, discharge, stand
With it is filling, obtain gel.
Preferably, gained gel in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low-frequency gauge auxiliary imports skin, and assimilation effect is more preferably.
The present invention also provides a kind of preparation methods for improving skin lines creme, include the following steps:
(1) it is anti-bad that hyaluronic acid, trehalose, epithelical cell growth factor, Gotu Kola P.E, L- are weighed respectively according to the ratio
Hematic acid 2- glucoside, glutathione, glucan, cross-linking hyaluronic acid sodium and Collagenase, addition weight percent are 3.0-
10.0% glycerol stirs 15~20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the match Bick 305 that weight percent is 1.0~3.0% is added, after evenly dispersed,
Then, under high velocity agitation be added weight percent be 5.0~80.0% water, 3.0~7.0% caprylic/capric glycerol
Three esters and 5.0~6.0% isopropyl palmitate, after being dispersed with stirring uniformly, finally, being separately added into weight percent according to the ratio and being
0.1~0.3% Chlorphenesin, 0.3~0.5% Phenoxyethanol and 0.1~0.2% essence, stir 30~50min after,
Obtain mixture B；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index after complying with standard, discharge, stand
With it is filling, obtain creme.
Preferably, gained creme in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low-frequency gauge auxiliary imports skin, and assimilation effect is more preferably.
The present invention also provides a kind of preparation methods for improving skin lines hydrogel patch, include the following steps:
(1) it is anti-bad that hyaluronic acid, trehalose, epithelical cell growth factor, Gotu Kola P.E, L- are weighed respectively according to the ratio
Hematic acid 2- glucoside, glutathione, glucan, cross-linking hyaluronic acid sodium and Collagenase stir 15~20min, uniformly divide
After dissipating, mixture A is obtained；
(2) respectively by weight percent be 6.0~7.0% Sodium Polyacrylate, 0.10~0.25% Dihydroxyaluminium Aminoacetate and 0.1
~0.2% disodium ethylene diamine tetraacetate is added in the glycerol that weight percent is 20~25%, is subsequently added into weight percent
For 0.25~0.30% tartaric acid, 0.1~0.3% Chlorphenesin, 0.3~0.5% Phenoxyethanol, 0.1~0.2% perfume (or spice)
Smart, 5.0~65.0% water and the mixture A are coated in lining material after being stirred under vacuum uniformly, after crosslinking curing, system
At hydrogel patch.
Preferably, lining material is clad aluminum foil, polyethylene, polyvinyl chloride, polypropylene, polystyrene, polyester, poly- terephthaldehyde
One of sour second diester and non-woven fabrics are a variety of.
Preferably, gained hydrogel patch in use, can be placed directly against skin surface, can also be by beauty
Effective ingredient is imported skin by the beauty apparatus such as instrument, ultrasound, infrared, electric pulse, middle low-frequency gauge auxiliary, and assimilation effect is more preferably.
The invention has the benefit that
1, the present invention provides a kind of composition for improving skin lines, pass through hyaluronic acid, epithelical cell growth factor
Organically combined with Gotu Kola P.E etc., can deep layer nourishes rough skin, promote cell growth, promote collagen and fibronectin
Synthesis and reparation improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin of AA 2G
The effect of C can reduce the loss of active constituent, improve composition stability, safety are mild.
2, that creativeness is gone back in composition provided by the invention joined the collagen being widely present in tissue
Enzyme and cross-linking hyaluronic acid sodium.Wherein, Collagenase can not only be filled the cell tissue shunk, be dehydrated, and
Have the function of efficient catalytic, older protein and unstable peptide chain can be rapidly depleted, eliminates recess wrinkle, compact flesh
Skin, to repair skin lines in itself.Cross-linking hyaluronic acid sodium can improve skin growth condition, be dermal collagen
Synthesis with elastomer provides superior external environment, and the effect for repairing microgroove is played in the supply of reinforced nutrition matter, and
And cross-linking hyaluronic acid sodium can prevent the generation of some enzymes in cell, reduce the formation of free radical, prevent free radical from destroying
Eucaryotic cell structure generates lipid peroxidation and causes skin aging etc. and plays an important role.Therefore, the composition can effectively change
Kind skin lines.
3, the present invention also provides the preparation methods for improving skin lines composition, and not only simple process, is easy to implement big
Large-scale production, and pass through the available lotion of the preparation method, Essence, gel, creme, ointment, tincture, paint, film
The diversified forms product such as agent and patch (emplastrum containing gel) can satisfy the diversification selection of different clients, extend consumer group
Body.
4, the present invention also provides a kind of application methods of composition, in use by micropin, ultrasound, it is infrared,
The beauty apparatus such as electric pulse, middle low frequency auxiliary imports skin, and relative to being directly coated with, this method assimilation effect is more preferably.
Below by attached drawing, the present invention will be further described.
Detailed description of the invention
Fig. 1 is the striae of pregnancy comparison diagram of six weeks front and backs of Essence of the improvement skin lines provided using embodiment 1.
Fig. 2 is the striae of pregnancy comparison diagram of one week front and back of Essence of the improvement skin lines provided using embodiment 2.
Fig. 3 is the striae of pregnancy comparison diagram of one week front and back of gel of the improvement skin lines provided using embodiment 4.
Fig. 4 is the striae of pregnancy comparison diagram of one week front and back of creme of the improvement skin lines provided using embodiment 6.
Fig. 5 is the striae of pregnancy comparison diagram before and after the patch surrounding of the improvement skin lines provided using embodiment 8.
Specific embodiment
Illustrate embodiments of the present invention below by way of specific specific implementation, those skilled in the art can be by this specification
Other advantages and efficacy of the present invention can be easily understood for disclosed content.
Embodiment 1
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 1.0%；Trehalose 1.0%；Epithelical cell growth factor 2.0%；Gotu Kola P.E 2.0%；L-AA 2- glucose
Glycosides 2.0%；Glutathione 0.5%；Glucan 3.0%；Cross-linking hyaluronic acid sodium 0.1%；Collagenase 0.1%.
The composition is Essence form.
The present embodiment additionally provides this preparation method for improving skin lines Essence, comprising the following steps:
(1) weigh respectively weight percent be 1.0% hyaluronic acid, 1.0% trehalose, 2.0% epidermal cell
Growth factor, 2.0% Gotu Kola P.E, 2.0% AA 2G, 0.5% glutathione, 3.0%
Glucan, 0.1% cross-linking hyaluronic acid sodium and 0.1% Collagenase, be added weight percent be 7.0% it is sweet
Oil stirs 15min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the water that weight percent is 80.6% is added, is stirred at 50r/min, Zhi Daosuo
Have component after mixing, be separately added into according to the ratio weight percent be 0.1% Chlorphenesin, 0.4% Phenoxyethanol and
0.2% essence obtains mixture B after stirring 30min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain Essence.
Essence obtained by the present embodiment in use, can directly be applied to skin surface, can also by micropin,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, using skin striae of pregnancy can be effectively improved after six weeks,
It is detailed in Fig. 1.
The preparation method provided in this embodiment for improving skin lines Essence, simple process are easy to implement extensive life
It produces.
Embodiment 2
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 0.1%；Trehalose 5.0%；Epithelical cell growth factor 2.0%；Gotu Kola P.E 1.0%；L-AA 2- glucose
Glycosides 1.0%；Glutathione 0.5%；Glucan 5.0%；Cross-linking hyaluronic acid sodium 1.5%；Collagenase 0.5%.
The composition is Essence form.
The present embodiment additionally provides this preparation method for improving skin lines Essence, comprising the following steps:
(1) weigh respectively weight percent be 0.1% hyaluronic acid, 5.0% trehalose, 2.0% epidermal cell
Growth factor, 1.0% Gotu Kola P.E, 1.0% AA 2G, 0.5% glutathione, 5.0%
Glucan, 1.5% cross-linking hyaluronic acid sodium and 0.5% Collagenase, be added weight percent be 5.0% it is sweet
Oil stirs 18min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the water that weight percent is 77.7% is added, is stirred at 50r/min, Zhi Daosuo
Have component after mixing, be separately added into according to the ratio weight percent be 0.1% Chlorphenesin, 0.3% Phenoxyethanol and
0.1% essence obtains mixture B after stirring 35min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain Essence.
Essence obtained by the present embodiment in use, can directly be applied to skin surface, can also by micropin,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, using skin striae of pregnancy can be effectively improved after a week,
It is detailed in Fig. 2.
The preparation method provided in this embodiment for improving skin lines Essence, simple process are easy to implement extensive life
It produces.
Embodiment 3
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 8.0%；Trehalose 15.0%；Epithelical cell growth factor 0.1%；Gotu Kola P.E 5.0%；L-AA 2- glucose
Glycosides 1.0%；Glutathione 5.0%；Glucan 10.0%；Cross-linking hyaluronic acid sodium 10.0%；Collagenase 8.0%.
The composition is Essence form.
The present embodiment additionally provides this preparation method for improving skin lines Essence, comprising the following steps:
(1) weigh respectively weight percent be 8.0% hyaluronic acid, 15.0% trehalose, 0.1% epidermal cell
Growth factor, 5.0% Gotu Kola P.E, 1.0% AA 2G, 5.0% glutathione, 10.0%
Glucan, 10.0% cross-linking hyaluronic acid sodium and 8.0% Collagenase, be added weight percent be 5.0% it is sweet
Oil stirs 20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the water that weight percent is 32.0% is added, is stirred at 60r/min, Zhi Daosuo
Have component after mixing, be separately added into according to the ratio weight percent be 0.3% Chlorphenesin, 0.5% Phenoxyethanol and
0.1% essence obtains mixture B after stirring 50min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain Essence.
Essence obtained by the present embodiment in use, can directly be applied to skin surface, can also by micropin,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, skin lines can be effectively improved using one week.
The preparation method provided in this embodiment for improving skin lines Essence, simple process are easy to implement extensive life
It produces.
Embodiment 4
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 3.0%；Trehalose 5.0%；Epithelical cell growth factor 0.1%；Gotu Kola P.E 2.0%；L-AA 2- glucose
Glycosides 1.0%；Glutathione 0.5%；Glucan 5.0%；Cross-linking hyaluronic acid sodium 0.1%；Collagenase 0.1%.
The composition is gel form.
The present embodiment additionally provides this preparation method for improving skin lines gel, comprising the following steps:
(1) weigh respectively weight percent be 3.0% hyaluronic acid, 5.0% trehalose, 0.1% epidermal cell
Growth factor, 2.0% Gotu Kola P.E, 1.0% AA 2G, 0.5% glutathione, 5.0%
Glucan, 0.1% cross-linking hyaluronic acid sodium and 0.1% Collagenase, be added weight percent be 7.0% it is sweet
Oil stirs 15min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, water that add weight percentage is 74.9% and the card wave 940 for being 0.3%, dispersion is equal
After even, it is subsequently added into the triethanolamine that weight percent is 0.3%, is stirred until substantially uniformity mixing in the stirring of 50r/min
After mixing uniformly, it is separately added into Chlorphenesin, 0.4% Phenoxyethanol and 0.2% essence that weight percent is 0.1% according to the ratio,
After stirring 30min, mixture B is obtained；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain gel.
Gel obtained by the present embodiment in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, using skin striae of pregnancy can be effectively improved after a week,
It is detailed in Fig. 3.
The preparation method provided in this embodiment for improving skin lines gel, simple process are easy to implement large-scale production.
Embodiment 5
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 0.1%；Trehalose 5.0%；Epithelical cell growth factor 8.0%；Gotu Kola P.E 1.0%；L-AA 2- glucose
Glycosides 1.0%；Glutathione 0.5%；Glucan 3.0%；Cross-linking hyaluronic acid sodium 0.1%；Collagenase 8.0%.
The composition is gel form.
The present embodiment additionally provides this preparation method for improving skin lines gel, comprising the following steps:
(1) weigh respectively weight percent be 0.1% hyaluronic acid, 5.0% trehalose, 8.0% epidermal cell
Growth factor, 1.0% Gotu Kola P.E, 1.0% AA 2G, 0.5% glutathione, 3.0%
Glucan, 0.1% cross-linking hyaluronic acid sodium and 8.0% Collagenase, be added weight percent be 5.0% it is sweet
Oil stirs 20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, water that add weight percentage is 66.4% and the card wave 940 for being 0.6%, dispersion is equal
After even, it is subsequently added into the triethanolamine that weight percent is 0.6%, is stirred until substantially uniformity mixing in the stirring of 60r/min
After mixing uniformly, it is separately added into Chlorphenesin, 0.3% Phenoxyethanol and 0.1% essence that weight percent is 0.3% according to the ratio,
After stirring 50min, mixture B is obtained；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain gel.
Gel obtained by the present embodiment in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, skin lines can be effectively improved using one week.
The preparation method provided in this embodiment for improving skin lines gel, simple process are easy to implement large-scale production.
Embodiment 6
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 3.0%；Trehalose 5.0%；Epithelical cell growth factor 1.0%；Gotu Kola P.E 2.0%；L-AA 2- glucose
Glycosides 2.0%；Glutathione 1.0%；Glucan 3.0%；Cross-linking hyaluronic acid sodium 1.0%；Collagenase 2.0%.
The composition is cream.
The present embodiment additionally provides this preparation method for improving skin lines creme, comprising the following steps:
(1) weigh respectively weight percent be 3.0% hyaluronic acid, 5.0% trehalose, 1.0% epidermal cell
Growth factor, 2.0% Gotu Kola P.E, 2.0% AA 2G, 1.0% glutathione, 3.0%
Glucan, 1.0% cross-linking hyaluronic acid sodium and 2.0% Collagenase, be added weight percent be 7.0% it is sweet
Oil stirs 20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the match Bick 305 that weight percent is 2.0% is added, after evenly dispersed, then,
It is different that 60.3% water, 5.0% caprylic/capric triglyceride and 5.0% palmitinic acid that weight percent is are added under high velocity agitation
Propyl ester, after being dispersed with stirring uniformly, finally, being separately added into Chlorphenesin, the 0.4% benzene oxygen that weight percent is 0.1% according to the ratio
Ethyl alcohol and 0.2% essence obtain mixture B after stirring 30min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain creme.
Creme obtained by the present embodiment in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, using skin striae of pregnancy can be effectively improved after a week,
It is detailed in Fig. 4.
The preparation method provided in this embodiment for improving skin lines creme, simple process are easy to implement large-scale production.
Embodiment 7
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 5.0%；Trehalose 15.0%；Epithelical cell growth factor 6.0%；Gotu Kola P.E 2.0%；L-AA 2- glucose
Glycosides 2.0%；Glutathione 5.0%；Glucan 3.0%；Cross-linking hyaluronic acid sodium 5.0%；Collagenase 5.0%.
The composition is cream.
The present embodiment additionally provides this preparation method for improving skin lines creme, comprising the following steps:
(1) weigh respectively weight percent be 5.0% hyaluronic acid, 15.0% trehalose, 6.0% epidermal cell
Growth factor, 2.0% Gotu Kola P.E, 2.0% AA 2G, 5.0% glutathione, 3.0%
Glucan, 5.0% cross-linking hyaluronic acid sodium and 5.0% Collagenase, be added weight percent be 10.0% it is sweet
Oil stirs 20min, after evenly dispersed, obtains mixture A；
(2) in the mixture A, the match Bick 305 that weight percent is 3.0% is added, after evenly dispersed, then,
It is different that 28.0% water, 7.0% caprylic/capric triglyceride and 6.0% palmitinic acid that weight percent is are added under high velocity agitation
Propyl ester, after being dispersed with stirring uniformly, finally, being separately added into Chlorphenesin, the 0.5% benzene oxygen that weight percent is 0.3% according to the ratio
Ethyl alcohol and 0.2% essence obtain mixture B after stirring 50min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index.It is specific as follows: pH value 6~7 it
Between, it is just qualified；It is placed at 40 DEG C or so for 24 hours, mixture B form is normal after restoring room temperature, and heat resistance is qualified；On -15 DEG C of left sides
For 24 hours, mixture B form is normal after restoring room temperature for right placement, and cold tolerance is qualified；48h is cultivated at 37 DEG C, is examined in clean room
Total number of bacteria meets the bacterial number in cosmetics health specification claimed range, qualified.Through after the assay was approved, using ampere bottle
It is filling, obtain creme.
Creme obtained by the present embodiment in use, can directly be applied to skin surface, can also by beauty instrument,
The beauty apparatus such as ultrasonic, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, skin lines can be effectively improved using one week.
The preparation method provided in this embodiment for improving skin lines creme, simple process are easy to implement large-scale production.
Embodiment 8
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 3.0%；Trehalose 5.0%；Epithelical cell growth factor 1.0%；Gotu Kola P.E 2.0%；L-AA 2- glucose
Glycosides 2.0%；Glutathione 1.0%；Glucan 3.0%；Cross-linking hyaluronic acid sodium 1.0%；Collagenase 2.0%.
The composition is hydrogel plaster sheet form.
The present embodiment additionally provides this preparation method for improving skin lines hydrogel patch, comprising the following steps:
(1) weigh respectively weight percent be 3.0% hyaluronic acid, 5.0% trehalose, 1.0% epidermal cell
Growth factor, 2.0% Gotu Kola P.E, 2.0% AA 2G, 1.0% glutathione, 3.0%
Glucan, 1.0% cross-linking hyaluronic acid sodium and 2.0% Collagenase, stir 16min, after evenly dispersed, mixed
Close object A；
(2) respectively by weight percent be 6.0% Sodium Polyacrylate, 0.15% Dihydroxyaluminium Aminoacetate and 0.1% ethylenediamine tetraacetic
Acetic acid disodium is added in the glycerol that weight percent is 25%, is subsequently added into tartaric acid, 0.1% that weight percent is 0.25%
Chlorphenesin, 0.4% Phenoxyethanol, 0.2% essence, 47.8% water and the mixture A, be stirred under vacuum uniformly after, coating
On non-woven fabrics, after crosslinking curing, hydrogel patch is made.
In addition to non-woven fabrics, lining material can also be clad aluminum foil, polyethylene, polyvinyl chloride, polypropylene, polystyrene, polyester
One of with polyethylene terephthalate.
Hydrogel patch obtained by the present embodiment in use, can be placed directly against skin surface, can also be by beauty
The beauty apparatus such as looks, ultrasound, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, using skin striae of pregnancy can be effectively improved after four weeks,
It is detailed in Fig. 5.
The preparation method provided in this embodiment for improving skin lines hydrogel patch, simple process are easy to implement big rule
Mould production.
Embodiment 9
The present embodiment provides a kind of composition for improving skin lines, the functional component of the composition is as follows: hyalomitome
Acid 5.0%；Trehalose 3.0%；Epithelical cell growth factor 3.0%；Gotu Kola P.E 1.0%；L-AA 2- glucose
Glycosides 1.0%；Glutathione 2.0%；Glucan 5.0%；Cross-linking hyaluronic acid sodium 2.0%；Collagenase 3.0%.
The composition is hydrogel plaster sheet form.
The present embodiment additionally provides this preparation method for improving skin lines hydrogel patch, comprising the following steps:
(1) weigh respectively weight percent be 5.0% hyaluronic acid, 3.0% trehalose, 3.0% epidermal cell
Growth factor, 1.0% Gotu Kola P.E, 1.0% AA 2G, 2.0% glutathione, 5.0%
Glucan, 2.0% cross-linking hyaluronic acid sodium and 3.0% Collagenase, stir 16min, after evenly dispersed, mixed
Close object A；
(2) respectively by weight percent be 7.0% Sodium Polyacrylate, 0.25% Dihydroxyaluminium Aminoacetate and 0.2% ethylenediamine tetraacetic
Acetic acid disodium is added in the glycerol that weight percent is 20%, is subsequently added into tartaric acid, 0.2% that weight percent is 0.3%
Chlorphenesin, 0.3% Phenoxyethanol, 0.1% essence, 46.65% water and the mixture A, be stirred under vacuum uniformly after, coating
On non-woven fabrics, after crosslinking curing, hydrogel patch is made.
In addition to polyethylene terephthalate, lining material can also be clad aluminum foil, polyethylene, polyvinyl chloride, polypropylene, gather
One of styrene, polyester and non-woven fabrics.
Hydrogel patch obtained by the present embodiment in use, can be placed directly against skin surface, can also be by beauty
The beauty apparatus such as looks, ultrasound, infrared, electric pulse, middle low frequency auxiliary imports skin, and assimilation effect is more preferably.
The composition provided in this embodiment for improving skin lines, passes through hyaluronic acid, epithelical cell growth factor and product
The combination of careless extract etc. is avenged, energy deep layer nourishes rough skin promotes cell growth, promotes the conjunction of collagen and fibronectin
At and repair, improve crackle symptom, and then desalinate microgroove；By adding this natural vitamin C of AA 2G,
The effect of capable of reducing the loss of active constituent, improving composition stability, safety is mild.Also, it is also created in the composition
Property joined the Collagenase and cross-linking hyaluronic acid sodium being widely present in tissue.Wherein, Collagenase is not
The cell tissue shunk, be dehydrated can be only filled, and have the function of efficient catalytic, can rapidly depleted older
Protein and unstable peptide chain eliminate recess wrinkle, compact skin, to repair skin lines in itself；Cross-linked transparent
Matter acid sodium can improve skin growth condition, provide superior external environment for the synthesis of dermal collagen and elastomer,
The effect for repairing microgroove is played in the supply of reinforced nutrition matter.Meanwhile cross-linking hyaluronic acid sodium can prevent some enzymes in cell
Generation, reduce the formation of free radical, preventing free radical from destroying eucaryotic cell structure, generating lipid peroxidation and cause skin aging
Etc. play an important role.The composition in actual use, skin lines can be effectively improved using one week.
The preparation method provided in this embodiment for improving skin lines hydrogel patch, simple process are easy to implement big rule
Mould production.
The above, only presently preferred embodiments of the present invention, above-described embodiment is merely exemplary illustrate the principle of the present invention and
Its effect, and not to the present invention in any form with substantial limitation.It should be pointed out that for the common skill of the art
Art personnel can also make several improvement and supplement under the premise of not departing from the method for the present invention, these are improved and supplement
It should be regarded as protection scope of the present invention.All those skilled in the art, in the feelings for not departing from the spirit and scope of the present invention
It is this when the equivalent variations for a little variation, modification and evolution made using disclosed above technology contents under condition
The equivalent embodiment of invention；Meanwhile all substantial technologicals that obtains according to the present invention are to any equivalent variations made by above-described embodiment
Variation, modification and evolution, in the range of still falling within technical solution of the present invention.
Claims (11)
1. a kind of composition for improving skin lines, the component comprising following weight percentage: hyaluronic acid 0.1~8.0%；Sea
Algae sugar 1.0~15.0%；Epithelical cell growth factor 0.1~8.0%；Gotu Kola P.E 1.0~5.0%；L-AA
2- glucoside 1.0~2.0%；Glutathione 0.5~5.0%；Glucan 3.0~10.0%；Cross-linking hyaluronic acid sodium 0.1~
10.0%；Collagenase 0.1~8.0%.
2. the composition according to claim 1 for improving skin lines, it is characterised in that: the composition forms are cream
One of liquid, Essence, gel, creme, ointment, tincture, paint, film and patch are a variety of.
3. the preparation method of the composition according to claim 1 for improving skin lines, includes the following steps:
(1) it weighs the component in claim 1 respectively according to the ratio, the glycerol that weight percent is 5.0-7.0%, stirring 15 is added
~20min after evenly dispersed, obtains mixture A；
(2) in the mixture A, the water that weight percent is 25.0-86.0% is added, is stirred at 50~60r/min, directly
After mixing to all components, be separately added into according to the ratio weight percent be 0.1~0.3% Chlorphenesin, 0.3~
0.5% Phenoxyethanol and 0.1~0.2% essence obtain mixture B after stirring 30~50min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index, after complying with standard, discharging stands and fills
Dress, obtains Essence.
4. the application of Essence obtained by preparation method according to claim 3, it is characterised in that: the Essence uses micro-
One of needle, ultrasound, infrared, electric pulse, middle low frequency instrument or a variety of auxiliary import skin.
5. the preparation method of the composition according to claim 1 for improving skin lines, includes the following steps:
(1) it weighs the component in claim 1 respectively according to the ratio, the glycerol that weight percent is 5.0-7.0%, stirring 15 is added
~20min after evenly dispersed, obtains mixture A；
(2) in the mixture A, the weight percent water for being 20.0~86.0% and the card wave for being 0.1~0.6% is added
940, after being uniformly dispersed, 50~60r/min stirring, until substantially uniformity mix, be subsequently added into weight percent be 0.1~
0.6% triethanolamine is separately added into the Chlorphenesin, 0.3 that weight percent is 0.1~0.3% after mixing evenly according to the ratio
~0.5% Phenoxyethanol and 0.1~0.2% essence obtain mixture B after stirring 30~50min；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index, after complying with standard, discharging stands and fills
Dress, obtains gel.
6. the application of gel obtained by preparation method according to claim 5, it is characterised in that: the gel uses beauty
One of instrument, ultrasound, infrared, electric pulse, middle low frequency instrument or a variety of auxiliary import skin.
7. the preparation method of the composition according to claim 1 for improving skin lines, includes the following steps:
(1) it weighs the component in claim 1 respectively according to the ratio, the glycerol that weight percent is 3.0-10.0%, stirring is added
15~20min after evenly dispersed, obtains mixture A；
(2) in the mixture A, the match Bick 305 that weight percent is 1.0~3.0% is added, after evenly dispersed, then,
Water, 3.0~7.0% caprylic/capric triglycerides and 5.0 that weight percent is 5.0~80.0% are added under high velocity agitation
~6.0% isopropyl palmitate, after being dispersed with stirring uniformly, finally, being separately added into weight percent according to the ratio is 0.1~0.3%
Chlorphenesin, 0.3~0.5% Phenoxyethanol and 0.1~0.2% essence, stir 30~50min after, obtain mixture B；
(3) pH of the inspection mixture B, heat-resisting, cold-resistant and bacterial number index, after complying with standard, discharging stands and fills
Dress, obtains creme.
8. the application of creme obtained by preparation method according to claim 7, it is characterised in that: the creme uses beauty
One of instrument, ultrasound, infrared, electric pulse, middle low frequency instrument or a variety of auxiliary import skin.
9. the preparation method of the composition according to claim 1 for improving skin lines, includes the following steps:
(1) it weighs the component in claim 1 respectively according to the ratio, stirs 15~20min, after evenly dispersed, obtain mixture A；
(2) respectively by weight percent be 6.0~7.0% Sodium Polyacrylate, 0.10~0.25% Dihydroxyaluminium Aminoacetate and 0.1~
0.2% disodium ethylene diamine tetraacetate is added in the glycerol that weight percent is 20~25%, and being subsequently added into weight percent is
0.25~0.30% tartaric acid, 0.1~0.3% Chlorphenesin, 0.3~0.5% Phenoxyethanol, 0.1~0.2% perfume (or spice)
Smart, 5.0~65.0% water and the mixture A are coated in lining material after being stirred under vacuum uniformly, after crosslinking curing, system
At hydrogel patch.
10. the preparation method of the composition according to claim 9 for improving skin lines, it is characterised in that: the lining material
For in clad aluminum foil, polyethylene, polyvinyl chloride, polypropylene, polystyrene, polyester, polyethylene terephthalate and non-woven fabrics
It is one or more.
11. the application of hydrogel patch obtained by preparation method according to claim 10, it is characterised in that: the hydrogel
After patch is attached to skin surface, led using one of beauty instrument, ultrasound, infrared, electric pulse, middle low frequency instrument or a variety of auxiliary
Enter skin.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297727A (en) * | 2019-12-25 | 2020-06-19 | 华熙生物科技股份有限公司 | Beautifying and plasticizing treatment composition and application thereof |
| CN111616980A (en) * | 2020-07-13 | 2020-09-04 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN115944553A (en) * | 2022-12-07 | 2023-04-11 | 华熙生物科技股份有限公司 | Application of oligopeptide in improving stability of cross-linked hyaluronic acid or salt thereof |
-
2018
- 2018-08-31 CN CN201811015817.0A patent/CN108938492A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297727A (en) * | 2019-12-25 | 2020-06-19 | 华熙生物科技股份有限公司 | Beautifying and plasticizing treatment composition and application thereof |
| CN111616980A (en) * | 2020-07-13 | 2020-09-04 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN111616980B (en) * | 2020-07-13 | 2023-02-14 | 华熙生物科技股份有限公司 | Complex enzyme preparation, preparation method thereof and application thereof in tattooing |
| CN115944553A (en) * | 2022-12-07 | 2023-04-11 | 华熙生物科技股份有限公司 | Application of oligopeptide in improving stability of cross-linked hyaluronic acid or salt thereof |
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Application publication date: 20181207 |