CN108938447A - A kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate - Google Patents
A kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate Download PDFInfo
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- CN108938447A CN108938447A CN201810932937.0A CN201810932937A CN108938447A CN 108938447 A CN108938447 A CN 108938447A CN 201810932937 A CN201810932937 A CN 201810932937A CN 108938447 A CN108938447 A CN 108938447A
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- Prior art keywords
- fullerene
- fullerene derivate
- face cream
- cosmetic composition
- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate, it is related to cosmetic field, the composition is according to parts by weight, including following raw material: -11-8 parts of oligopeptides, 3-7 parts of fullerene derivate, 5-12 parts of Sodium Hyaluronate, Rosa Damascana 3-8, caffeine 3-6.Cosmetic composition of the present invention is applied in face cream, facial spot, microgroove and wrinkle can effectively be desalinated, allow face skin being capable of lasting moisturizing in dry and cold environment, skin repair damaged tissues can be helped simultaneously, it gets well state, face is reduced after use because of the dry microgroove generated, enable face skin water profit it is tender it is white, moisten it is glossy.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of cosmetics group containing oligopeptides -1 and fullerene derivate
Close object and face cream.
Background technique
With advancing age, the aggravation of environmental pollution, metabolism start to slow down, and sebaceous glands and sweat gland function are slowly
Decline, dermal layer of the skin can be thinning, and pigment can also deposit, in addition people are often against computer office, remaining time is then from not
The radiation for opening mobile phone screen causes skin elasticity to be lost, jaundice, blackening, wrinkle, color spot occurs.Studies have shown that due to skin
Aging is influenced by many factors such as ethnic group, region, environment, living habits, therefore correctly skin nursing can be with maximum journey
Degree ground reduces skin damage, so that skin is become pale glossy, the aging of delaying skin.
The face cream of current market sales of skin whitening, moisturizing function is mostly very different, some face creams are not such as publicity
Functional effect is consistent, though effective component is marked with addition, effect is unobvious, some face creams can even cause skin after use
The adverse reactions such as skin allergy, such as some businessmans do not stint to reach whitening effect and add lead arsenic mercury and exceeded into product
Quinhydrones, lead to problems such as the skin of consumer occur other be more difficult to solve side effect.
Fullerene is a kind of very strong antioxidant, and oxidation resistance is ascorbic 125 times, while fullerene
Also have the effects that remove free radical, activating skin cells, prevention cell ageing, but since fullerene has in aqueous solution
Repellency, oxidation resistance are restricted due in solution in water, therefore to give full play to the oxidation resistance of fullerene
It must be made to some modifications and change with the ability for removing free radical, therefore, preparation, which is added with, can play its oxidation resistance
Fullerene and play the face cream of whitening function jointly with other whitening compositions, give people seeking beauty to provide more selections, be one
A project highly studied.
Summary of the invention
The technical issues of in the presence of the prior art, the present invention propose a kind of derivative containing oligopeptides -1 and fullerene
The cosmetic composition and face cream of object, can be with overcome the deficiencies in the prior art.The face cream that the present invention is prepared has good
Skin whitening, moisturizing effect, while having many advantages, such as that inoxidizability is strong, it can effectively prevent skin of face aging, desalination microgroove.
The present invention proposes a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate, by weight, describedization
Cosmetic compositions include following raw material:
Preferably, the raw material for preparing of the fullerene derivate includes fullerene and nitrine-three polyethylene glycol-carboxylic acid；It will
Fullerene, which is dissolved in organic solvent, is added to reactor, and-three polyethylene glycol of nitrine-for being dissolved in organic solvent is added thereto
Carboxylic acid is heated to 60-90 DEG C, and insulation reaction added organic solvent after 24-72 hours, was heated to 90-110 DEG C, insulation reaction
5-10 hours, organic solvent is rotated out, obtain fullerene derivate and has neither part nor lot in the black solid fullerene of reaction, silicagel column
Chromatography purifying removes fullerene, obtains carboxylic fullerene derivate.
Preferably, the molar ratio of the fullerene and-three polyethylene glycol of the nitrine-carboxylic acid is 1:5-15.
Preferably, the organic solvent includes one of tetrahydrofuran, toluene, ethyl acetate and dioxane or more
Kind.
Preferably, the structural formula of the fullerene derivate are as follows:
In addition, also providing a kind of face cream, according to parts by weight, the face cream includes following raw material: describedization
Preferably, the moisturizer includes glycerol, butanediol and hexylene glycol.
Preferably, the emollient is vaseline, and the thickener includes guar gum and xanthan gum.
Compared with prior art, the invention has the following advantages:
Contain carboxyl and multiple ehter bonds in the fullerene derivate being added in inventive formulation, increases the fullerene
The polarity and hydrophily of derivative, solve the repellency of fullerene in aqueous solution, and fullerene derivate be likewise supplied with it is excellent
Different free radical scavenging ability cooperates with that adds in formula to have the oligopeptides -1 for calming down wrinkle, firm skin, has whitening function
The Rosa Damascana and caffeine of effect, Sodium Hyaluronate and moisturizer and emollient with moisture-keeping efficacy make to be prepared
The face cream effectively inhibits the formation of melanin on the basis of improving skin water lock power, while anti-wrinkle effect is obvious, makes institute
Face cream is stated with efficient anti-aging, Bearberry Extract fundamentally solves dermal melanin deposition, microgroove color spot increases, skin
The skin problems such as the dry tarnish of skin.
Specific embodiment
In order to further explain the technical solution of the present invention and effect is clearer, clear, below to the present invention into one
Step is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this
Invention.
Embodiment 1
A kind of cosmetic composition containing oligopeptides -1 and fullerene derivate, by weight, the cosmetic composition
Including following raw material:
The cosmetic composition the preparation method is as follows: respectively by corresponding proportion by oligopeptides -1, fullerene derivate,
Rosa Damascana, caffeine and Sodium Hyaluronate are added in reaction pot, 20-40 DEG C at a temperature of, after being uniformly mixed,
It is cooled to room temperature and obtains the cosmetic composition.
The raw material for preparing of the fullerene derivate includes fullerene and nitrine-three polyethylene glycol-carboxylic acid；By fullerene
It is dissolved in organic solvent and is added to reactor ,-three polyethylene glycol of the nitrine-carboxylic acid for being dissolved in organic solvent is added thereto, adds
Heat arrives 60-90 DEG C, and insulation reaction added organic solvent after 24-72 hours, was heated to 90-110 DEG C, insulation reaction 5-10 is small
When, organic solvent is rotated out, fullerene derivate is obtained and has neither part nor lot in the black solid fullerene of reaction, silica gel column chromatography point
Fullerene is removed from purifying, obtains carboxylic fullerene derivate, the fullerene is C60Fullerene.The richness being prepared
Strangling ene derivative has preferable water solubility, can give full play to its free radical scavenging ability in formula, have excellent antioxygen
Change, wrinkle resistance.
The molar ratio of the fullerene and-three polyethylene glycol of the nitrine-carboxylic acid is 1:5-15.
The organic solvent includes one of tetrahydrofuran, toluene, ethyl acetate and dioxane or a variety of.
The structural formula of the fullerene derivate are as follows:
In addition, another embodiment also provides a kind of face cream, according to parts by weight, the face cream includes following original
The moisturizer includes glycerol, butanediol and hexylene glycol, the weight part ratio of the glycerol, butanediol and hexylene glycol
For 1-2:3-5:2-7.
The emollient is vaseline, and the thickener includes guar gum and xanthan gum, the guar gum and the xanthan
The weight part ratio of glue is 1-3:2-5.
The present embodiment solves fullerene water-soluble by fullerene derivate of the preparation containing carboxyl and multiple ehter bonds
Repellency in liquid more solves to solve the fullerene defect insoluble with other components in formula with hydrophobic
The shortcomings that anti-oxidation efficacy of property fullerene can not be put to good use, i.e. fullerene derivate freedom with super strength in tissue
Base Scavenging activity is equipped with the hyperplasia with stimulation epidermal cell, endothelial cell, promotes various kinds of cell in epidermal cell tissue
Growth division, make epidermal cell become it is full, restore younger state oligopeptides -1, and with brighten, the rhodamine toner of moisture-keeping functions
Oil and caffeine, Sodium Hyaluronate synergistic effect under, so that prepared face cream is fundamentally solved the melanin of skin
The skin problems such as deposition, microgroove hyperplasia, dry skin water shortage, are effectively improved skin to the resistance of adverse circumstances and self repair
Reactivation power makes the long-acting holding water of skin moisten glossy, recovery skin vitality.
Embodiment 2
On the basis of embodiment 1, the present embodiment 2 is used as the preferred embodiment of the present invention, and one kind containing oligopeptides -1 and fowler
The cosmetic composition of ene derivative, by weight, the cosmetic composition include following raw material:
A kind of face cream, according to parts by weight, the face cream include following raw material:
Wherein, in the preparation process of the fullerene derivate, the fullerene and-three polyethylene glycol of the nitrine-carboxylic
The molar ratio of acid is 1:10；The organic solvent is the mixed solvent of toluene and dioxane proportionally 20:80, is heated to
80 DEG C, insulation reaction adds the mixed solvent after 48 hours, is heated to 100 DEG C, insulation reaction 5-10 hours, rotates out
After the organic solvent of part be added ether to rotate before volume, continue revolving removal solvent after, obtain fullerene derivate and
Part has neither part nor lot in the black solid fullerene of reaction, fullerene is removed using silica gel column chromatography separating purification method, wherein eluting
Agent toluene or dimethylbenzene obtain carboxylic fullerene derivate.
The weight part ratio of the glycerol, butanediol and hexylene glycol is 1.5:4:4.5；The guar gum and the xanthan gum
Weight part ratio be 2:3.5.
Embodiment 3
On the basis of embodiment 2, the present embodiment 3 is used as the preferred embodiment of the present invention, and one kind containing oligopeptides -1 and fowler
The cosmetic composition of ene derivative, by weight, the cosmetic composition include following raw material:
A kind of face cream, according to parts by weight, the face cream include following raw material:
Wherein, the molar ratio of the fullerene and-three polyethylene glycol of the nitrine-carboxylic acid is 1:12；The fullerene spreads out
The preparation process of biology is the same as embodiment 2.
Embodiment 4
On the basis of embodiment 2, the present embodiment 4 is used as the preferred embodiment of the present invention, and one kind containing oligopeptides -1 and fowler
The cosmetic composition of ene derivative, by weight, the cosmetic composition include following raw material:
A kind of face cream, according to parts by weight, the face cream include following raw material:
Wherein, the molar ratio of the fullerene and-three polyethylene glycol of the nitrine-carboxylic acid is 1:5；The fullerene spreads out
The preparation process of biology is the same as embodiment 2.
Comparative example 1
On the basis of embodiment 2, fullerene derivate described in heretofore described cosmetic composition is gone
Fall, corresponding face cream is prepared with embodiment 2 in other components and proportion.
Comparative example 2
On the basis of embodiment 2, oligopeptides -1 described in the cosmetic composition in the present invention is removed,
Corresponding face cream is prepared with embodiment 2 in his component and proportion.
Choose that 150 genders are identical, be of the similar age, face has that color spot, skin be pitch-dark, the volunteer more than microgroove, every group 30
Five groups of status, the face cream being prepared respectively using embodiment 2-4 and comparative example 1-2 is obtained after 28 days such as following table one
Experimental result.Wherein, using the method for face cream are as follows: after the thorough clean skin of volunteer, corresponding face cream is uniformly applied to face,
Sooner or later respectively using primary.
Table one
By the experimental result of table one it is found that the face cream being prepared in embodiment 2-4 lightens the stain microgroove, increases
The face cream that white effect is superior to be prepared in comparative example 1-2 obtains when removing fullerene derivate and oligopeptides -1
Face cream product desalination facial lines color spot and whitening effect decline it is more, only serve simple moisturizing effect and therefore adopt
There is preferably facial lines, spot dilution capacity with the face cream that inventive formulation component and proportion are prepared and make skin
Become more smooth pale effect.
In conclusion the present invention by composition proportion appropriate, makes water-soluble fullerene derivate and oligopeptides -1 and matches
It mutually acts synergistically between each component in side, the face cream being prepared is enable utmostly to play the whitening of each component
Moisture-keeping efficacy can generate permanent all day, lasting water lock moistening effect, and energy bright color, promotion complexion to skin, adhere to
It is used for a long time, skin properties can be made to be improved, hair pore shrinkage, skin becomes smooth, reaches skin whitening, moisturizing effect on the whole
Fruit makes one in high spirits, more aobvious young self-confident.
Those skilled in the art will be clear that the scope of the present invention is not limited to example discussed above, it is possible to its into
Several changes of row and modification, the scope of the present invention limited without departing from the appended claims.Although oneself is through in the description
The present invention is described in detail, but such illustrate and describe is only explanation or schematical, and not restrictive.The present invention is simultaneously
It is not limited to the disclosed embodiments.
Claims (9)
1. a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate, which is characterized in that by weight, the makeup
Product composition includes following raw material:
2. a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate according to claim 1, which is characterized in that
The raw material for preparing of the fullerene derivate includes fullerene and nitrine-three polyethylene glycol-carboxylic acid；Fullerene is dissolved in organic molten
It is added to reactor in agent ,-three polyethylene glycol of the nitrine-carboxylic acid for being dissolved in organic solvent is added thereto, is heated to 60-90
DEG C, insulation reaction added organic solvent after 24-72 hours, is heated to 90-110 DEG C, insulation reaction 5-10 hours, rotates out
Solvent obtains fullerene derivate and has neither part nor lot in the black solid fullerene of reaction, and silica gel column chromatography separating purification removes rich
Alkene is strangled, carboxylic fullerene derivate is obtained.
3. a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate according to claim 2, which is characterized in that
The molar ratio of the fullerene and-three polyethylene glycol of the nitrine-carboxylic acid is 1:5-15.
4. a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate according to claim 2, which is characterized in that
The organic solvent includes one of tetrahydrofuran, toluene, ethyl acetate and dioxane or a variety of.
5. a kind of cosmetic composition containing oligopeptides -1 and fullerene derivate according to claim 1, which is characterized in that
The structural formula of the fullerene derivate are as follows:
6. a kind of face cream, which is characterized in that according to parts by weight, the face cream includes following raw material: as weighed
7. a kind of face cream according to claim 6, which is characterized in that the moisturizer include glycerol, butanediol and oneself two
Alcohol.
8. a kind of face cream according to claim 6, which is characterized in that the emollient is vaseline.
9. a kind of face cream according to claim 6, which is characterized in that the thickener includes guar gum and xanthan gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810932937.0A CN108938447A (en) | 2018-08-16 | 2018-08-16 | A kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810932937.0A CN108938447A (en) | 2018-08-16 | 2018-08-16 | A kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate |
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| Publication Number | Publication Date |
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| CN108938447A true CN108938447A (en) | 2018-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810932937.0A Pending CN108938447A (en) | 2018-08-16 | 2018-08-16 | A kind of cosmetic composition and face cream containing oligopeptides -1 and fullerene derivate |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897987A (en) * | 2019-12-16 | 2020-03-24 | 广州熙然化妆品有限公司 | Composition for resisting wrinkles and tightening skin and application of composition in cosmetics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101475520A (en) * | 2008-12-31 | 2009-07-08 | 同济大学 | Preparation of water-soluble fullerene |
| WO2018064504A1 (en) * | 2016-09-30 | 2018-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for functionalizing carbon nanoparticles and compositions |
-
2018
- 2018-08-16 CN CN201810932937.0A patent/CN108938447A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101475520A (en) * | 2008-12-31 | 2009-07-08 | 同济大学 | Preparation of water-soluble fullerene |
| WO2018064504A1 (en) * | 2016-09-30 | 2018-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for functionalizing carbon nanoparticles and compositions |
Non-Patent Citations (3)
| Title |
|---|
| 佚名: "CMM (郑明明) 润泉水能量高保湿面霜", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_A826337651.HTML》 * |
| 李天灵: "《女人内调外养美颜经》", 31 August 2009, 吉林科学技术出版社 * |
| 柳东芳等: "C60与叠氮化合物的单加成反应", 《化学通报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897987A (en) * | 2019-12-16 | 2020-03-24 | 广州熙然化妆品有限公司 | Composition for resisting wrinkles and tightening skin and application of composition in cosmetics |
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Application publication date: 20181207 |