CN108904769A - A kind of pharmaceutical composition and preparation method thereof for treating Black Hills sheep dysentery - Google Patents
A kind of pharmaceutical composition and preparation method thereof for treating Black Hills sheep dysentery Download PDFInfo
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- CN108904769A CN108904769A CN201810904340.5A CN201810904340A CN108904769A CN 108904769 A CN108904769 A CN 108904769A CN 201810904340 A CN201810904340 A CN 201810904340A CN 108904769 A CN108904769 A CN 108904769A
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- 208000001848 dysentery Diseases 0.000 title claims abstract description 22
- 241001494479 Pecora Species 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 16
- 239000003814 drug Substances 0.000 claims abstract description 37
- BITDLWAQPKSXTF-UHFFFAOYSA-M 1-[(3-nitrophenyl)methoxymethyl]pyridin-1-ium;chloride Chemical compound [Cl-].[O-][N+](=O)C1=CC=CC(COC[N+]=2C=CC=CC=2)=C1 BITDLWAQPKSXTF-UHFFFAOYSA-M 0.000 claims abstract description 12
- 229960002581 moroxydine hydrochloride Drugs 0.000 claims abstract description 12
- HOBWAPHTEJGALG-JKCMADFCSA-N [(1r,5s)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfate Chemical compound [O-]S([O-])(=O)=O.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1.C([C@H]1CC[C@@H](C2)[NH+]1C)C2OC(=O)C(CO)C1=CC=CC=C1 HOBWAPHTEJGALG-JKCMADFCSA-N 0.000 claims abstract description 10
- 229960002028 atropine sulfate Drugs 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241001504477 Pycnonotidae Species 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 6
- 235000001405 Artemisia annua Nutrition 0.000 claims abstract description 5
- 240000000011 Artemisia annua Species 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 2
- 240000006891 Artemisia vulgaris Species 0.000 claims 1
- 229930003347 Atropine Natural products 0.000 claims 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 229960000396 atropine Drugs 0.000 claims 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 3
- 241000283707 Capra Species 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 235000019687 Lamb Nutrition 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000034347 Faecal incontinence Diseases 0.000 description 1
- 241000219991 Lythraceae Species 0.000 description 1
- 241000283903 Ovis aries Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000010513 Stupor Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 206010030306 omphalitis Diseases 0.000 description 1
- 206010030899 opisthotonus Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/80—Scrophulariaceae (Figwort family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract
The invention discloses a kind of compositions and preparation method thereof for treating Black Hills sheep dysentery, use that 6~10 parts of Radix picrorrhizae, 8~12 parts of granatum, 8~12 parts of rhizoma zingiberis, 8~12 parts of sweet wormwood, 7~10 parts of Cortex Phellodendri, 8~12 parts of the bark of ash, 14~17 parts of the Chinese bulbul, 7~10 parts of dried orange peel is raw material, it is decocted after being crushed, medicament is made after filtering；The medicament can effectively treat the symptom of goat dysentery, and treatment cycle is short, cure rate is high, safe and reliable；Especially by atropine sulfate and Moroxydine Hydrochloride piece is added, in such a way that Chinese and Western combines, so that forming the effect of cooperateing between drug, and then realize that cure rate reaches 100% in a short time, does not recur, is a kind of ideal pharmaceutical preparation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of pharmaceutical composition for treating Black Hills sheep dysentery and its preparation side
Method.
Background technique
Dysentery is the hemorrhagic infectious disease of the acute poison of one kind of the new-bom lamb as caused by clostridieum welchii Type B；With violent diarrhea and
Small intestine occurs ulcer and is characterized, and the lamb in this 7 age in days of sick main harm can cause large quantities of death, be to influence lamb survival rate
A kind of common disease；1. the occurrence of this disease and prevalence, and heavy ewe is malnutritive, nursing is improper, lambing season weather is prominent
Change, sheep hurdle darkness humidity etc. have substantial connection；In addition, lactation is improper, hungry satisfies that irregular, sanitation and hygiene condition is poor when delivering lambs, educating lamb
Deng this disease can also be induced；Propagating source is sick lamb excrement, and through alimentary canal, umbilical cord and wound infection, incubation period is generally 1~2 day,
It is some birth a few houres, different because of pathogen difference；2. just lamb spirit is depressed for clinical symptoms disease, appetite stimulator or stopping are fed
Cream, subsequent 1~2 day, sick lamb diarrhea atherosclerotic or water sample object, color had green, yellowish green, greyish white etc., and foul smelling taste, body temperature are increased to
39.5℃；Sick lamb is dispirited stay stand, the bow back of a bow, abdomen it is recessed, band blood, fecal incontinence in later period excrement；Due to persistent diarrhea, body
Temperature is relatively low, and through death in 1~2 day, nervous symptoms, salivation, teeth clenched, opisthotonos, tic of limbs or mind occurred in single cases
Will stupor, is come to an end with death.
But in the prior art, due to using western medicine merely mostly for the drug for the treatment of lamb dysentery, and Western medicine
Price costly, therapeutic effect is bad, is easy to appear recurrence, and toxic side effect is also larger；It is treated using Chinese medicine, is treated mostly
Period is longer, works slow, is easy delay treatment.
Summary of the invention
The technical problem to be solved in the present invention is to provide the pharmaceutical compositions that a kind of Chinese medicine having no toxic side effect controls sheep dysentery, originally
Invention also provides the preparation method of said medicine combination.
In order to solve the above-mentioned technical problem, the technical scheme is that a kind of pharmaceutical composition for treating Black Hills sheep dysentery and
Preparation method.
It is achieved particular by following technical scheme：
A kind of pharmaceutical composition for treating Black Hills sheep dysentery, the raw material including following parts by weight：6~10 parts of Radix picrorrhizae, pomegranate
It is 8~12 parts of skin, 8~12 parts of rhizoma zingiberis, 8~12 parts of sweet wormwood, 7~10 parts of Cortex Phellodendri, 8~12 parts of the bark of ash, 14~17 parts of the Chinese bulbul, old
7~10 parts of skin.
It further include having atropine sulfate or Moroxydine Hydrochloride piece in the raw material.
A kind of preparation method of pharmaceutical composition that treating Black Hills sheep dysentery adds water after being mixed the Chinese medicine
It is decocted after flooding medicinal material, decoction liquor is filtered, obtain medicament.The medicament is according to 100ml：The ratio of 1~3mg is added
Atropine sulfate；Or the medicament is according to 100ml：The ratio of 4~6mg adds Moroxydine Hydrochloride piece；Or the medicament is pressed
According to 100ml：The ratio of 1~3mg adds atropine sulfate, according to 100ml：The ratio of 4~6mg adds Moroxydine Hydrochloride piece.
The present invention has following beneficial effect：
By adopting the above technical scheme, due to using 6~10 parts of Radix picrorrhizae, 8~12 parts of granatum, 8~12 parts of rhizoma zingiberis, sweet wormwood
8~12 parts, 7~10 parts of Cortex Phellodendri, 8~12 parts of the bark of ash, 14~17 parts of the Chinese bulbul, 7~10 parts of dried orange peel be raw material, Chinese medicine is nontoxic secondary to be made
With, decocted after being crushed, after filtering be made medicament；By adopting the above technical scheme, due to by be added sulfuric acid Ah
Tropine and Moroxydine Hydrochloride piece, in such a way that Chinese and Western combines, so that the effect of collaboration is formed between drug, and then realize short-term
Interior cure rate reaches 100%, and treatment cycle is short, cure rate is high, does not recur securely and reliably.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Embodiment 1
A kind of pharmaceutical composition for treating Black Hills sheep dysentery, the raw material including following parts by weight：Radix picrorrhizae 6g, granatum 8g,
Rhizoma zingiberis 8g, sweet wormwood 8g, Cortex Phellodendri 7g, bark of ash 8g, Chinese bulbul 14g, dried orange peel 7g.
After above-mentioned Chinese medicine is mixed, is decocted after adding water submerged medicinal material, decoction liquor is filtered, obtain medicine
Agent.
Embodiment 2, using the identical formula of same embodiment 1, difference is preparation method difference, and embodiment 2 is according to above-mentioned
Formula measures each Chinese medicine, mixes after being rinsed well using clear water, is put into pulverizer and is crushed to 60~80 mesh, adds its weight
4~6 times of water decoct 2~3h, and filtered filtration residue is added 1~2 times of water and decocts 1~1.5h, filtering；Will twice filtered filtrate into
Row merges, and obtains medicament.
Embodiment 3, using the identical technical solution of same embodiment 1, difference is, above-mentioned medicament is pressed with atropine sulfate
According to according to 100ml：The ratio of 1~3mg mixes.
Embodiment 4, using the identical technical solution of same embodiment 1, difference is, by above-mentioned medicament according to 100ml：4~
The ratio of 6mg adds Moroxydine Hydrochloride piece.
Embodiment 5, using the identical technical solution of same embodiment 1, difference is, by above-mentioned medicament according to 100ml：1~
The ratio of 3mg adds atropine sulfate, according to 100ml：The ratio of 4~6mg adds Moroxydine Hydrochloride piece.
For trying lamb：It selects in the identical black goat lamb with dysentery of feeding and management condition and selects 168 at random, at random
It is divided into 5 groups, every group of drug prepared respectively according to 1~embodiment of embodiment, 5 scheme gavages three times, continuous 3d, medication daily
Afterwards, the patient's condition of daily observation disease record lamb after 3d, is respectively analyzed the therapeutic effect of each group, as a result such as following table：
| Group | Treatment number/only | Healing number/only | Cure rate/% |
| Embodiment 1 | 30 | 24 | 80% |
| Embodiment 2 | 34 | 29 | 85% |
| Embodiment 3 | 29 | 26 | 90% |
| Embodiment 4 | 37 | 34 | 92% |
| Embodiment 5 | 38 | 38 | 100% |
As seen from the experiment, lamb dysentery, embodiment can effectively be treated using drug prepared by 1 scheme of embodiment
2 optimize preparation method in the scheme of embodiment 1, and then enhance drug effect, and cure rate has reached 85%；Embodiment
3 will carry out compatible use in the drug for 1 scheme of the embodiment preparation that atropine sulfate is added, so that cure rate has reached 90%；
Embodiment 4 will carry out compatible use in the drug for 1 scheme of the embodiment preparation that Moroxydine Hydrochloride piece is added, so that cure rate reaches
92%；Atropine sulfate and Moroxydine Hydrochloride piece are added to progress compatibility in the drug of 1 scheme of embodiment preparation simultaneously to be made
With so that the effect of forming collaboration between drug, so that therapeutic effect is obviously improved, cure rate reaches 100%.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (7)
1. a kind of pharmaceutical composition for treating Black Hills sheep dysentery, it is characterised in that：Raw material including following parts by weight：Radix picrorrhizae 6~
10 parts, 8~12 parts of granatum, 8~12 parts of rhizoma zingiberis, 8~12 parts of sweet wormwood, 7~10 parts of Cortex Phellodendri, 8~12 parts of the bark of ash, the Chinese bulbul 14~
17 parts, 7~10 parts of dried orange peel.
2. the pharmaceutical composition for the treatment of Black Hills sheep dysentery as described in claim 1, it is characterised in that：It further include having sulphur in the raw material
Sour atropine or Moroxydine Hydrochloride piece.
3. a kind of preparation method for the pharmaceutical composition for treating Black Hills sheep dysentery is used to prepare treatment Black Hills as described in claim 1
The pharmaceutical composition of sheep dysentery, it is characterised in that：By 6~10 parts of the Radix picrorrhizae, 8~12 parts of granatum, 8~12 parts of rhizoma zingiberis, blueness
8~12 parts of wormwood artemisia, 7~10 parts of Cortex Phellodendri, 8~12 parts of the bark of ash, 14~17 parts of the Chinese bulbul, 7~10 parts of dried orange peel mixed after, add water logging
It is decocted after not having medicinal material, decoction liquor is filtered, obtain medicament.
4. the preparation method of the pharmaceutical composition for the treatment of Black Hills sheep dysentery as claimed in claim 3, it is characterised in that：According to formula ratio
Each Chinese medicine is taken, is mixed after being rinsed well using clear water, is put into pulverizer and is crushed to 60~80 mesh, adds 4~6 times of its weight
Water decocts 2~3h, and filtered filtration residue is added 1~2 times of water and decocts 1~1.5h, filtering；It filtered filtrate will close twice
And obtain medicament.
5. the preparation method of the pharmaceutical composition for the treatment of Black Hills sheep dysentery as claimed in claim 4, it is characterised in that：The medicament is pressed
According to 100ml：The ratio of 1~3mg adds atropine sulfate.
6. the preparation method of the pharmaceutical composition for the treatment of Black Hills sheep dysentery as claimed in claim 4, it is characterised in that：The medicament is pressed
According to 100ml：The ratio of 4~6mg adds Moroxydine Hydrochloride piece.
7. the preparation method of the pharmaceutical composition for the treatment of Black Hills sheep dysentery as claimed in claim 4, it is characterised in that：The medicament is pressed
According to 100ml：The ratio of 1~3mg adds atropine sulfate, according to 100ml：The ratio of 4~6mg adds Moroxydine Hydrochloride piece.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109331079A (en) * | 2018-12-18 | 2019-02-15 | 河南农业大学 | Veterinary Chinese medicinal composition, veterinary drug and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929685A (en) * | 2017-11-16 | 2018-04-20 | 思南县邵家桥镇洪国山羊养殖场 | A kind of composition for treating lamb dysentery and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107929685A (en) * | 2017-11-16 | 2018-04-20 | 思南县邵家桥镇洪国山羊养殖场 | A kind of composition for treating lamb dysentery and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109331079A (en) * | 2018-12-18 | 2019-02-15 | 河南农业大学 | Veterinary Chinese medicinal composition, veterinary drug and its preparation method and application |
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