CN108888751A - One kind is for treating and preventing arthritic composition and preparation method thereof - Google Patents
One kind is for treating and preventing arthritic composition and preparation method thereof Download PDFInfo
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- CN108888751A CN108888751A CN201810893678.5A CN201810893678A CN108888751A CN 108888751 A CN108888751 A CN 108888751A CN 201810893678 A CN201810893678 A CN 201810893678A CN 108888751 A CN108888751 A CN 108888751A
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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Abstract
The invention discloses one kind for treating and preventing arthritic composition and preparation method thereof, the composition includes 2 ~ 20 parts of raw material cucumber seed powder, 2 ~ 20 parts of bone collagen Gly-His-Lys, 1 ~ 11 part of Poria cocos powder, 0.8 ~ 8 part of inulin, 0.7 ~ 7 part of polydextrose powder, 0.5 ~ 5 part of konjaku flour, 0.06 ~ 0.56 part of aspartase calcium powder, 0.45 ~ 4.5 part of oatmeal, 0.06 ~ 0.6 part of Red jujube flavor, 0.01 ~ 0.1 part of Sucralose.The present composition use ingredient is less, good drug efficacy；Take the drug, after the state of an illness obtains medical treatment, the state of an illness can further be consolidated by continuing to take, prevent it is arthritic fall ill again, increase resistance of human body, and there is no any side effect to human body.
Description
Technical field
The invention belongs to pharmaceutical technology fields.More particularly to one kind for treating and preventing arthritic composition and its system
Preparation Method.
Background technique
As modern people's the accelerating rhythm of life, the increase of operating pressure, Working Life are accustomed to irregular, China's trouble
There is the number of the diseases such as rheumatoid arthritis, cervical spondylosis, caput femoris necrosis to increase year by year.
Cervical spondylosis is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis etc., is strained for a long time mainly due to cervical vertebra, hyperostosis
It is comprehensive that raw or Disc herniation, ligament thicken the clinic for causing cervical vertebra spinal cord, vertebral artery to be pressurized a series of functional disorders occurred
Simulator sickness；Caput femoris necrosis then will lead to the functional disorders such as bony structure change, collapse of femoral head, deformation, arthritis.These
The presence of disease can carry out the influence answered to the normal life of people, work belt, and when serious people can not carry out normally
Life and work.Therefore, for（Rheumatoid）The therapeutic agent and method of the diseases such as arthritis, cervical spondylosis, caput femoris necrosis
It is badly in need of carrying out in-depth study.
Currently, the therapeutic agent and treatment method for joint diseases such as cervical spondylosis, arthritis, caput femoris necrosis are existing more
Kind, such as western medicine, therapy of combing traditional Chinese and Western medicine, acupuncture, but for a long time using western medicine there are biggish side effect, it is right
Body impacts and palliative.Therapy of combing traditional Chinese and Western medicine and its and acupuncture combination for diseases such as cervical spondylosis, arthritis
Disease has preferable effect, but therapeutic effect is single, cannot preferably prevent the obvious recurrence of later period disease.
Summary of the invention
To solve the above-mentioned problems, the present invention provides one kind for treating and preventing arthritic composition and its preparation
Method.The composition that this method is prepared can preferable treatment of arthritis, to body be not present any side effect；The drug
Patient body immunity can be significantly improved while treating disease, further increase treatment curative effect while can also be had
The obvious recurrence function of effect prevention disease.
The present invention is achieved by the following technical solutions
For one kind for treating and preventing arthritic composition, the composition includes the raw material of following parts by weight：Cucumber seed powder 2 ~
20 parts, 2 ~ 20 parts of bone collagen Gly-His-Lys, 1 ~ 11 part of Poria cocos powder, 0.8 ~ 8 part of inulin, 0.7 ~ 7 part of polydextrose powder, konjaku flour
0.5 ~ 5 part, 0.06 ~ 0.56 part of aspartase calcium powder, 0.45 ~ 4.5 part of oatmeal, 0.06 ~ 0.6 part of Red jujube flavor, three
0.01 ~ 0.1 part of chlorine sucrose.
Described is used to treat and prevent arthritic composition, and the composition includes the raw material of following parts by weight：Cucumber
20 parts of seed powder, 10 parts of bone collagen Gly-His-Lys, 9 parts of Poria cocos powder, 6 parts of inulin, 7 parts of polydextrose powder, 4 parts of konjaku flour, lucid asparagus
Propylhomoserin chelates 0.3 part of calcium powder, 4 parts of oatmeal, 0.3 part of Red jujube flavor, 0.1 part of Sucralose.
Described is used to treat and prevent arthritic composition, and the bone collagen peptide is ox bone collagen protein peptides
Or pig bone collagen peptide.
Described is used to treat and prevent arthritic composition, and the preparation method of the cucumber seed powder specifically includes following
Step：
a：The cucumber seed powder cleaned up is placed in reaction kettle with deionized water and is mixed, is extracted 3 times under the conditions of 90 ~ 100 DEG C,
Obtain extracting solution；In extraction process, the quality of cucumber seed and deionized water be 1：6~10；
b：After the completion of extraction, extracting solution is filtered using 320 meshes, obtains filtrate；Then to filter under the conditions of 70 ~ 80 DEG C
Liquid carries out double effect concentration, obtains concentrate；
c：Obtained concentrate is placed in spray drying tower and is dried, inlet air temperature when dry is 110 ~ 130 DEG C, outlet air
Temperature is 60 ~ 70 DEG C；Dry moisture content≤8% into cucumber seed powder, i.e., it is dry to complete.
It is described for treating and preventing arthritic composition, the preparation method of the bone collagen Gly-His-Lys include with
Lower step：
A：The pig bone cleaned up or ox bone are taken, is placed in reaction kettle, deionization material is added；Then under the conditions of 90 ~ 100 DEG C
Boiling 3 ~ 4 hours, complete boiling；
B：After the completion of boiling, the mixture after boiling is filtered using tubular filter（Remove the objects such as broken bone therein
Matter）, take filtrate；Filtrate is cooled to 40 ~ 50 DEG C；Protease is added in filtrate after the cooling period to be digested, enzymatic hydrolysis 3 ~ 6 is small
When, that is, complete the enzymatic hydrolysis to pig bone or ox bone；
C：After the completion of enzymatic hydrolysis, the mixture after enzymatic hydrolysis is filtered, obtains enzymatic hydrolysis filtrate, the aperture of filter membrane used is
0.45nm；After the completion of filtering, double effect concentration is carried out to enzymatic hydrolysis filtrate under the conditions of 60 ~ 70 DEG C, obtains concentrate；
D：Concentrate is placed in spray drying tower and is spray-dried, when inlet air temperature when dry is 110 ~ 130 DEG C, is dry
Leaving air temp be 60 ~ 70 DEG C；Dry moisture content≤8% into bone collagen peptide, it is dry to complete required for obtaining
Bone collagen Gly-His-Lys.
Described is used to treat and prevent arthritic composition, pig bone or ox bone and deionization in the addition reaction kettle
The mass ratio of water is 1：8~12；In the enzymolysis process, protease and raw material（Pig bone or ox bone）Mass ratio be 1：20~30；
The protease is trypsase or neutral proteinase.
Described is used to treat and prevent arthritic composition, and the preparation method of the Poria cocos powder specifically includes following step
Suddenly：
a)：The Poria cocos cleaned up is placed in reaction kettle with deionized water and is extracted, extracts three under the conditions of 90 ~ 100 DEG C
It is secondary, obtain extracting solution；Poria cocos and the mass ratio of deionized water are 1 in extraction process：6~10；
b)：After the completion of extraction, obtained extracting solution is filtered using 320 meshes, obtains filtrate；Then at 60 ~ 70 DEG C
Under the conditions of to filtrate carry out double effect concentration, obtain concentrate；
c)：Obtained concentrate is dried in spray drying tower, when inlet air temperature when dry is 110 ~ 130 DEG C, is dry
Leaving air temp be 60 ~ 70 DEG C, dry moisture content≤10% into Poria cocos powder, that is, complete it is dry, obtain Poria cocos powder.
Described is used to treat and prevent arthritic composition, and the preparation of the composition includes the following steps：
（1）Prepare raw material according to above-mentioned requirement, every kind of raw material is crushed, sieved with 100 mesh sieve；
（2）Parts by weight as requested weigh step（1）Each raw material prepared, all raw materials is mixed, in revolving speed
To stir 30 ~ 40min under conditions of 35 ~ 50r/min, stirs evenly, obtains the composition；
（3）By step（2）Obtained composition pack, every bag of weight are 8 ~ 10g；Resulting composition is taken with warm water, often
Day takes 2 times, every time one bag.
Composition prepared by the present invention, per packed 8 ~ 10g, a 20 packed boxes；
Instructions of taking is：Warm boiled water, once in the morning and once at night, each taking one bag, 30 days as a treatment course（Adult takes）.
Pharmacology analysis of the invention is as follows：
Cucumber seed：Its nature and flavor is sweet, cool, nontoxic；Cucumber seed replenishes the calcium, synthetism, bone strengthening, salubrity, to osteoporosis, legs and feet
The disease of the internal organs such as cramp, rheumatism, arthritis, cervical spondylosis and liver, stomach, spleen, lung has the function of replying treatment and health care, and energy
The interaction between human internal organ is enough adjusted, equilibrium state is at；The calcium content of cucumber seed is abundant, and calcium phosphine content is suitable for having
Repair bone impingement necrosis, the effect for strong bone of replenishing the calcium；
Bone collagen peptide：Collagen peptide is a kind of natural antioxidant, has good elimination effect to free radical；Glue
Former protein peptides possess unique amino acid composition, possess different physiological roles：Blood pressure lowering, immunocompetence, promotes calcium at anti-melanin
Absorption and Antiarthritic；Can promote osseocartilaginous reparation, in vivo it is a variety of metabolism reaction carry out place is provided；It can
It is preferable to increase bone density, slow down arthralgia and prevents osteoporosis；
Poria cocos powder：It is sweet in flavor, light, it is mild-natured；It is more containing terpene, polysaccharide, choline, fat, lecithin, potassium, magnesium etc. in Poria cocos powder
Kind element；Have effects that clearing damp and promoting diuresis, invigorating the spleen calming heart（The spleen has the function to transport and transform nutrients, main system blood）；With air making-up and spleen enlivening effect, taste phase table
In, taste are the foundation of acquired constitution, and The spleen has the function to transport and transform nutrients, by transporting, form cereal nutrient, transport bone, play the work of extra-nutrition
With；
Konjaku flour：Konjaku flour is the concentrate of konjaku nutritional ingredient, and principle active component is solvable to be konjaku glucomannan
Property hemicellulose；It can prevent and reduce intestinal tract disease；The calcium component dissolution wherein contained is easily absorbed by the body, can be compared with
Good absorption noxious material prevents noxious material from corroding articular cartilage.
Inulin：Inulin is deposit property polysaccharide in plant, is mainly derived from plant；Inulin is a kind of natural fructose polymer,
It is fermented in colon by a large amount of beneficial microbes as a kind of natural soluble dietary fiber, thus has plurality kinds of health care function
Energy；It can promote mineral absorption；Regulate and control blood lipid, reduce blood glucose；Intestinal bifidobacteria quantity can be promoted.
Polydextrose powder：Polydextrose is water-soluble dietary fiber, soluble easily in water for white or off-white powder particle,
Without special taste；Polydextrose can adjust blood lipid, reduce fat accumulation, reduce human plasma and hepatic cholesterol is horizontal, prevention and treatment
Coronary sclerosis；To prevent cardiovascular and cerebrovascular diseases, there is biggish benefit to defatigation person；Polydextrose quilt in enteron aisle
Fermentation, which generates short chain fatty acids, is acidified intestinal environment, and acidified environment promotes the absorption of mineral element, promotes suction of the enteron aisle to calcium
It receives.
Aspartase calcium powder：The calcium ion of aspartase calcium powder release is most easily absorbed by the body；Tianmen
Aspartic acid chelating calcium, which enters after blood, forms flowing calcium library, can be needed according to Human Physiology the place of calcium slowly release calcium from
Son is utilized for absorption of human body, while can increase bone density, without any side effects, tolerance is good, has no adverse reaction；The ingredient
Also there is good antifatigue effect；
Oatmeal：Oat is cholesterol-free, a small amount of fat with full cereals, rich in Soluble Fiber, β-polydextrose with
And vegetable soda, plant saponin etc.；It can reduce cholesterol, prevent osteoporosis；
By interaction between above each ingredient, preferably cartilage can be repaired, treatment of arthritis and and arthritis
Related disease plays the role of prevention simultaneously and improves immunity.
The present invention has following positive beneficial effect
For the present invention with cucumber seed powder, bone collagen peptide, Poria cocos powder and konjaku flour are main component, with inulin, polydextrose powder,
Chelating calcium powder, oatmeal, Red jujube flavor, Sucralose are the obtained composition of auxiliary element, can effective treatment of arthritis,
Cervical spondylosis arthritis and the headache as caused by cervical spondylosis, insomnia etc. and the diseases such as caput femoris necrosis, the composition are not present
Any side effect, and can improve the immunity of the human body while treating disease, effectively prevent disease palindromia.The composition system
Preparation Method is simple, safety is easy to operate, and any side effect is not present to human body in obtained composition, and is very beneficial for human body
It absorbs, has significant therapeutic effect for arthritis and disease related with arthritis；
It is complex procedures, at high cost, right different from preparing composition using a large amount of different types of drug ingedient in the prior art
There are certain side effects for human body.The present composition use ingredient is less, good drug efficacy；Take the drug, the state of an illness is controlled
After treatment, the state of an illness can further be consolidated by continuing to take, and prevented arthritic morbidity again, increased resistance of human body, and is right
Human body does not have any side effect.
Drug effect of the invention is further proved by following clinical trial：
1, patient：Totally 232 cases, wherein 132 people of male, 100 people of women；
2, symptom：
In male：Cervical spondylosis 80（Have between 30 years old to 65 years old）, arthritis 50（Have between 50 years old to 70 years old）, femur
Head necrosis 2（Between 30 ~ 45 years old）；
In women：Cervical spondylosis 35（Between 30 ~ 50 years old）, arthritis 64（Between 50 ~ 70 years old）, caput femoris necrosis 1（35~
45 years old）；
3, drug administration method：Warm water is taken, and takes two bags daily, and each one bag sooner or later；30 days as a treatment course
4, curative effect standards of grading：
Observation of pain：Not bitterly（0 point）；Pain but do not influence life and work（2 points）；Pain still receives, to life and work
Slightly influence（4 points）；Pain is difficult to endure, and influences life and work（6 points）；
Tenderness observation：Tenderness without（0 point）；There is tenderness, still endures（2 points）；Tenderness is obvious（4 points）；Slightly pressure is pain, refuses to stroke
（6 points）；
Swelling observation：Swelling measurement（0 point）；Mild swelling rises no more than the position and neighbouring apophysis（2 points）；Swelling, with this
Position is equal with adjacent bone protrusion（4 points）；Swelling is obvious, is more than the position and adjacent bone head protrusion（6 points）；
Dysfunction measurement：Nothing（0 point）；Slightly, i.e., it is no more than 30% than amplitude with strong side（2 points）；Moderate compares width with strong side
Degree few 31 ~ 50%（4 points）；Severe reduces 50% than amplitude with strong side（6 points）；
Clinical healing：Symptom completely disappears, and functional activity restores normal, is 0 point；
It is effective：Symptom is relieved, and function is restored substantially, can participate in normal work, declines 6 points；
Effectively：Symptom is relieved, and functional activity has improvement, can do slight work, rather 3 ~ 5 points of decline；
In vain：Compared with pre-treatment, symptom and sign improvement is unobvious, rather 3 points of decline；
The efficacy result for treating above-mentioned case：
The therapeutic effect of 232 patients and having no toxic side effect is recorded in detail, efficacy result is according to percentages, statistics
As a result as shown in table 1 below：
Table 1 tests the statistical result of case treatment curative effect
Clinical safety：
After taking for long periods of time, patient does not occur blister, pain or erythema, does not find to adverse reactions such as skin irritatins yet, i.e., should
Composition is that comparison is safe.
Clinical Application Analysis：
By the clinical observation of more complete case, the cure rate of patient is almost 100%, illustrates that the composition drug effect is relatively good；And
And warm water is taken, conveniently.
Specific embodiment
The present invention is described in more details below by specific embodiment, but is not intended to restrict the invention
Protection scope.In following embodiment：
The preparation method of cucumber seed powder used, includes the following steps：
a：The cucumber seed powder cleaned up is placed in reaction kettle with deionized water and is mixed, after mixing, 90 ~ 100 DEG C of conditions first
Lower progress first time extraction（The mass ratio of cucumber seed and deionized water is 1 when extracting for the first time:10）；It extracts and completes for the first time
Afterwards, it filters, obtained filter residue is mixed second of progress with deionized water and is extracted（Second cucumber seed filter residue when extracting and go from
The mass ratio of sub- water is 1:8）；It after the completion of second of extraction, filters, obtained filter residue is mixed to progress third time with deionized water
It extracts（The quality of cucumber seed filter residue and deionized water is 1 when third time is extracted:6）, obtain extracting solution；
b：Extracting solution is obtained to third time extraction completion using 320 meshes to be filtered, and takes filtrate；It is right under the conditions of 70 ~ 80 DEG C
Filtrate carries out double effect concentration, obtains concentrate；
c：Concentrate is placed in spray drying tower and is dried, the inlet air temperature of drying tower is 110 ~ 130 DEG C, leaving air temp is
60~70℃；Dry moisture content≤8% into cucumber seed powder, i.e. completion drying；It is cooled to room temperature, it is spare.
The preparation method of the bone collagen peptide, includes the following steps：
A：Take the pig bone cleaned up or ox bone, in reaction kettle, add deionization（The matter of ox bone or pig bone and deionized water
Amount is than being 1：8~12）；Then boiling 3 ~ 4 hours under the conditions of 90 ~ 100 DEG C, boiling is completed；
B：After the completion of boiling, the mixture after boiling is filtered using tubular filter（Remove the objects such as broken bone therein
Matter）, after filtering, take filtrate；Filtrate is cooled to 40 ~ 50 DEG C, neutral proteinase is added in filtrate after cooling and is digested（In
Property protease additional amount with the mass ratio of pig bone or ox bone being initially added into be 1：25）, digest 3 ~ 6 hours, i.e. completion pig bone
Or the enzymatic hydrolysis of ox bone；
C：After the completion of enzymatic hydrolysis, the mixture after enzymatic hydrolysis is filtered, obtains enzymatic hydrolysis filtrate, the aperture of filter membrane used is
0.45nm；Double effect concentration is carried out to enzymatic hydrolysis filtrate under the conditions of 60 ~ 70 DEG C after the completion of filtering, obtains concentrate；
D：Obtained concentrate is dried using spray drying tower, when inlet air temperature when dry is 110 ~ 130 DEG C, is dry
Leaving air temp be 60 ~ 70 DEG C；Dry moisture content≤8% into bone collagen peptide, it is dry to complete required for obtaining
Bone collagen Gly-His-Lys.
The preparation method of the Poria cocos powder, includes the following steps：
a）：It weighs a certain amount of Poria cocos cleaned up to extract in reaction kettle, and deionized water is added and is mixed, then
First time extraction is carried out under the conditions of 90 ~ 100 DEG C（Poria cocos and the mass ratio of deionized water are 1 when extracting for the first time:10）；First
It after the completion of secondary extraction, filters, deionized water is added in filter residue and carries out second of extraction（Second Poria cocos filter residue when extracting with go
The mass ratio of ionized water is 1:8）；It after the completion of second of extraction, filters, deionized water is added in filter residue and carries out third time extraction
（Poria cocos filter residue and the mass ratio of deionized water are 1 when third time is extracted:6）, extract and complete, obtain extracting solution；
b）：The extracting solution obtained after the completion of being extracted using 320 meshes to third time is filtered, takes filtrate；Then at 60 ~ 70 DEG C
Under conditions of to filtrate carry out double effect concentration, obtain concentrate；
c）：Obtained concentrate is placed in spray drying tower and is dried, inlet air temperature when dry is 110 ~ 130 DEG C, does
Leaving air temp when dry is 60 ~ 70 DEG C；Dry moisture content≤8% into Poria cocos powder, i.e. completion drying；It is cooled to room temperature, it is standby
With.
Inulin of the present invention, polydextrose powder, konjaku flour, (Xuchang member states biochemistry to be had asparagus fern door propylhomoserin chelating calcium powder
Limit company), oatmeal, Red jujube flavor, Sucralose be market purchase product.
Embodiment 1
For one kind for treating and preventing arthritic composition, the composition includes the raw material of following parts by weight：Cucumber seed powder 2
Part, 2 parts of bone collagen Gly-His-Lys, 1 part of Poria cocos powder, 0.8 part of inulin, 0.7 part of polydextrose powder, 0.5 part of konjaku flour, asparagine
0.06 part of calcium powder, 0.45 part of oatmeal, 0.06 part of Red jujube flavor, 0.01 part of Sucralose of acid chelating.
Embodiment 2
For one kind for treating and preventing arthritic composition, the composition includes the raw material of following parts by weight：Cucumber seed powder 20
Part, 20 parts of bone collagen Gly-His-Lys, 11 parts of Poria cocos powder, 8 parts of inulin, 7 parts of polydextrose powder, 5 parts of konjaku flour, asparatate chela
Close 0.56 part of calcium powder, 4.5 parts of oatmeal, 0.6 part of Red jujube flavor .1 parts of Sucralose.
Embodiment 3
For one kind for treating and preventing arthritic composition, the composition includes the raw material of following parts by weight：Cucumber seed powder 12
Part, 10 parts of bone collagen Gly-His-Lys, 6 parts of Poria cocos powder, 4 parts of inulin, 4 parts of polydextrose powder, 3 parts of konjaku flour, asparatate chela
Close 0.4 part of calcium powder, 2 parts of oatmeal, 0.4 part of Red jujube flavor, 0.03 part of Sucralose.
Embodiment 4
For one kind for treating and preventing arthritic composition, the composition includes the raw material of following parts by weight：Cucumber seed powder 20
Part, 10 parts of bone collagen Gly-His-Lys, 9 parts of Poria cocos powder, 6 parts of inulin, 7 parts of polydextrose powder, 4 parts of konjaku flour, asparatate chela
Close 0.3 part of calcium powder, 4 parts of oatmeal, 0.3 part of Red jujube flavor, 0.1 part of Sucralose.
Embodiment 5
Above-described embodiment 1 ~ 4 is described for treating and preventing arthritic composition, and the preparation method of the composition includes following
Step：
（1）Prepare raw material according to above-mentioned requirement, every kind of raw material is crushed, sieved with 100 mesh sieve；
（2）Parts by weight as requested weigh each middle raw material, and all raw materials are mixed, and are 35 ~ 50r/min in revolving speed
Under conditions of stir 30 ~ 40min, stir evenly to get to the composition；
（3）By step（2）Obtained composition pack, every bag of weight are 8 ~ 10g；Resulting composition is taken with warm water, often
Day takes 2 times, each taking one bag.
The typical case treated using composition made above：
Case 1
Song, women, 50 years old：Suffer from the double numbnesses of fingers of cervical spondylosis pressuring nerve, belongs to the light mid-term of illness；Take the medicine two weeks, disease
Person feels that symptom is substantially reduced；When taking third week, symptom after one month, there is remarkable efficacy almost without numbness of fingers feeling；
For the appearance for further preventing the illness, patient continues to take one month, not any uncomfortable appearance during taking,
Cervical spondylosis illness does not recur.
Case 2
Chen, male, 28 years old：Suffer from cervical spondylosis, vascular compression, main suit's headache；When taking the drug three weeks, headache symptom is changed
It is kind, substantially reduced, it after taking 1 course for the treatment of, is significantly improved, headache illness almost disappears；Continue to take the medicine one month
（One course for the treatment of）, duration of medication does not have any uncomfortable phenomenon to generate, and has been disappeared by the headache illness that cervical spondylosis causes,
Body immunity increases.
Case 3
Chen, male, 45 years old：Cervical spondylosis headache, stadium are longer.It takes the medicine and feels within two weeks that a degree of illness mitigates,
After one course for the treatment of, headache is significantly improved；Continue to take the medicine one month（One course for the treatment of）, duration of medication do not have any body not
Suitable phenomenon generates, and is obviously improved by the headache illness that cervical spondylosis causes.
Case 4
Zhang, male, 35 years old：Suffer from rheumatic arthritis, arthralgia, especially in winter or rainy weather, pain can aggravate；Clothes
After one course for the treatment of of the composition, pain is mitigated, and illness is improved.It then proceedes to take a course for the treatment of, during taking
Do not occur any uncomfortable phenomenon, and illness has apparent mitigation than before.
Case 5
Wei, women, 60 years old：Suffer from the case history of arthritis, existing recent two decades, arthroncus, pain；Take 1 course for the treatment of of the medicine
Afterwards, there is a degree of improvement.
Case 6
Liu, male, 32 years old：2015 because leading to bilateral femoral head necrosis, collapse of femoral head with hormone；Take the group of above-mentioned preparation
When closing 1 course for the treatment of of object, illness is not significantly improved, and continues after taking 1 course for the treatment of, improves significantly；Then two
After a course for the treatment of, continue to take 1 course for the treatment of, illness has obtained apparent improvement.During medication, body do not occur it is any not
Suitable phenomenon, and immunity obtains certain raising.
Claims (8)
1. one kind is for treating and preventing arthritic composition, it is characterised in that：The composition includes the original of following parts by weight
Material：2 ~ 20 parts of cucumber seed powder, 2 ~ 20 parts of bone collagen Gly-His-Lys, 1 ~ 11 part of Poria cocos powder, 0.8 ~ 8 part of inulin, polydextrose powder 0.7
~ 7 parts, 0.5 ~ 5 part of konjaku flour, 0.06 ~ 0.56 part of aspartase calcium powder, 0.45 ~ 4.5 part of oatmeal, Red jujube flavor
0.06 ~ 0.6 part, 0.01 ~ 0.1 part of Sucralose.
2. according to claim 1 for treating and preventing arthritic composition, which is characterized in that the composition includes
The raw material of following parts by weight：20 parts of cucumber seed powder, 10 parts of bone collagen Gly-His-Lys, 9 parts of Poria cocos powder, 6 parts of inulin, polydextrose powder
7 parts, 4 parts of konjaku flour, 0.3 part of aspartase calcium powder, 4 parts of oatmeal, 0.3 part of Red jujube flavor, 0.1 part of Sucralose.
3. according to claim 1 or 2 for treating and preventing arthritic composition, which is characterized in that the bone
Collagen peptide is ox bone collagen protein peptides or pig bone collagen peptide.
4. according to claim 1 or 2 for treating and preventing arthritic composition, which is characterized in that the cucumber
The preparation method of seed powder specifically includes following steps：
The cucumber seed cleaned up is mixed to be placed in reaction kettle with deionized water and is extracted, is extracted under the conditions of 90 ~ 100 DEG C
3 times, obtain extracting solution；In extraction process, the quality of cucumber seed and deionized water be 1：6~10；
The mixed solution obtained after the completion of extracting is filtered using 320 meshes, obtains filtrate；It is right under the conditions of 70 ~ 80 DEG C
Filtrate carries out double effect concentration, obtains concentrate；
Concentrate is placed in spray drying tower and is dried, inlet air temperature when dry is 110 ~ 130 DEG C, leaving air temp 60
~70℃；Dry moisture content≤8% into cucumber seed powder, i.e., it is dry to complete.
5. according to claim 1 or 2 for treating and preventing arthritic composition, which is characterized in that the gelatine
The preparation method of former protein peptide powder includes the following steps：
Take the pig bone cleaned up or ox bone, in reaction kettle, add deionized water；Then boiling under the conditions of 90 ~ 100 DEG C
3 ~ 4 hours, complete boiling；
After the completion of boiling, the mixture after boiling is filtered using tubular filter, takes filtrate；Filtrate is cooled to 40 ~
50℃；Protease is added in filtrate after the cooling period to be digested, digests 3 ~ 6 hours, that is, completes the enzymatic hydrolysis to pig bone or ox bone；
After the completion of enzymatic hydrolysis, the mixture after enzymatic hydrolysis is filtered, obtains enzymatic hydrolysis filtrate, the aperture of filter membrane used is 0.45nm；
After the completion of filtering, double effect concentration is carried out to enzymatic hydrolysis filtrate under the conditions of 60 ~ 70 DEG C, obtains concentrate；
Obtained concentrate is placed in spray drying tower and is dried, when inlet air temperature when dry is 110 ~ 130 DEG C, is dry
Leaving air temp be 60 ~ 70 DEG C, bone collagen Gly-His-Lys required for being obtained after the completion of dry.
6. according to claim 5 for treating and preventing arthritic composition, which is characterized in that the addition reaction
Pig bone or ox bone and the mass ratio of deionized water are 1 in kettle：8~12；In the enzymolysis process, the mass ratio of protease and raw material
It is 1：20~30；The protease is trypsase or neutral proteinase.
7. according to claim 1 or 2 for treating and preventing arthritic composition, which is characterized in that
The Poria cocos cleaned up is added in reaction kettle with deionized water and is extracted, is extracted three times under the conditions of 90 ~ 100 DEG C,
Obtain extracting solution；In extraction process, the mass ratio of Poria cocos and deionized water is 1：6~10；
It is filtered using the extracting solution that 320 meshes obtain extraction, obtains filtrate；Under conditions of 60 ~ 70 DEG C to filtrate into
Row double effect concentration, obtains concentrate；
Obtained concentrate is placed in spray drying tower and is dried, when inlet air temperature when dry is 110 ~ 130 DEG C, is dry
Leaving air temp be 60 ~ 70 DEG C, dry moisture content≤10% into Poria cocos powder, that is, complete it is dry, obtain Poria cocos powder.
8. according to claim 1 or 2 for treating and preventing arthritic composition, which is characterized in that the composition
Preparation include the following steps：
（1）Prepare raw material according to the requirement of claim 1, every kind of raw material is crushed, sieved with 100 mesh sieve；
（2）Parts by weight as requested weigh step（1）In each raw material, all raw materials are mixed, revolving speed be 35 ~
30 ~ 40min is stirred under conditions of 50r/min, is stirred evenly, is obtained the composition；
（3）By step（2）Obtained mixture pack, every bag of weight are 8 ~ 10g；Resulting composition daily 2 times, every time
Take one bag.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110720515A (en) * | 2019-10-25 | 2020-01-24 | 李玉保 | Bone collagen polypeptide composite nutrient for improving bone mineral density and preparation method thereof |
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| CN103141892A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Cucumber seed beverage and preparation method and application thereof |
| CN105962381A (en) * | 2016-05-11 | 2016-09-28 | 上海艾苛密进出口有限公司 | Composite collagen peptide powder and preparation method thereof |
| CN107510064A (en) * | 2016-06-16 | 2017-12-26 | 徐文平 | Hyposite fiber meal replacement powder and preparation method thereof |
| CN107889998A (en) * | 2017-11-28 | 2018-04-10 | 威海养经堂医药科技有限公司 | A kind of ossein chitosan oligosaccharide solid beverage |
| CN108853486A (en) * | 2018-05-04 | 2018-11-23 | 湖北和格复合骨胶原生物科技有限公司 | A kind of formulation product with strengthen immunity function |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103141892A (en) * | 2013-02-28 | 2013-06-12 | 康美药业股份有限公司 | Cucumber seed beverage and preparation method and application thereof |
| CN105962381A (en) * | 2016-05-11 | 2016-09-28 | 上海艾苛密进出口有限公司 | Composite collagen peptide powder and preparation method thereof |
| CN107510064A (en) * | 2016-06-16 | 2017-12-26 | 徐文平 | Hyposite fiber meal replacement powder and preparation method thereof |
| CN107889998A (en) * | 2017-11-28 | 2018-04-10 | 威海养经堂医药科技有限公司 | A kind of ossein chitosan oligosaccharide solid beverage |
| CN108853486A (en) * | 2018-05-04 | 2018-11-23 | 湖北和格复合骨胶原生物科技有限公司 | A kind of formulation product with strengthen immunity function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110720515A (en) * | 2019-10-25 | 2020-01-24 | 李玉保 | Bone collagen polypeptide composite nutrient for improving bone mineral density and preparation method thereof |
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Address after: 466200 No. 99, Jingwu Road, Xiangcheng Industrial Cluster District, Zhoukou City, Henan Province Applicant after: Beijing Jiuding Junjiandong Peptide Biotechnology City Co.,Ltd. Address before: 466200 No. 99, Jingwu Road, Xiangcheng Industrial Cluster District, Zhoukou City, Henan Province Applicant before: BEIJING JIUDING JUNJIAN PHARMACEUTICAL TECHNOLOGY XIANGCHENG Co.,Ltd. Address after: 466200 No. 99, Jingwu Road, Xiangcheng Industrial Cluster District, Zhoukou City, Henan Province Applicant after: Henan dongpeptide biology Co.,Ltd. Address before: 466200 No. 99, Jingwu Road, Xiangcheng Industrial Cluster District, Zhoukou City, Henan Province Applicant before: Beijing Jiuding Junjiandong Peptide Biotechnology City Co.,Ltd. |
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