CN108888680A - A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation - Google Patents
A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 63
- 208000031971 Yin Deficiency Diseases 0.000 title claims abstract description 22
- 244000286838 Eclipta prostrata Species 0.000 claims abstract description 18
- 240000000249 Morus alba Species 0.000 claims abstract description 18
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 18
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 18
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 241000405911 Rehmannia glutinosa Species 0.000 claims abstract description 11
- 241001247821 Ziziphus Species 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000002224 dissection Methods 0.000 claims description 6
- 239000012535 impurity Substances 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 17
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- 210000003734 kidney Anatomy 0.000 abstract description 13
- 210000004185 liver Anatomy 0.000 abstract description 13
- 238000003745 diagnosis Methods 0.000 abstract description 3
- 238000012216 screening Methods 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010044565 Tremor Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010016825 Flushing Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 201000010934 exostosis Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000003694 hair properties Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 201000010930 hyperostosis Diseases 0.000 description 1
- 230000002390 hyperplastic effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, the medicine preparation including following parts by weight is formed:The eclipta of 9-15 parts by weight, the Rehmannia glutinosa of 9-15 parts by weight, the Radix Paeoniae Alba of 6-12 parts by weight, the mulberry fruit of 9-15 parts by weight, the jujube of 9-15 parts by weight.The present invention is according to traditional Chinese medical theory, and theoretical using diagnosis and treatment carries out Chinese prescription screening, and formula is scientific and reasonable, and configuration is simple, has no toxic side effect, curative effect is short, quick.We are using enriching yin and nourishing kidney, replenishing blood and nourishing liver as principle of reatment, are first to cure mainly its root with enriching yin and nourishing kidney, supplemented by replenishing blood and nourishing liver, perfect square has the effect of enriching yin and nourishing kidney, replenishing blood and nourishing liver for the patient of liver-kidney yin deficiency osteoproliferation.
Description
Technical field
The present invention relates to a kind of Chinese medicine for treating osteoproliferation, more particularly to a kind of liver-kidney yin deficiency osteoproliferation for the treatment of
Chinese medicine.
Background technique
Hyperostosis is also known as hyperplastic osteoarthritis, Osteoarthritis etc., is cartilage, intervertebral due to constituting joint
The denaturation of the soft tissues such as disk, ligament is degenerated, and joint margins form spur, and the variation such as synovial membrane plumpness and osteoclasia occurs, cause after
The osteoproliferation of hair property, leads to dysarthrasis, when by abnormal load, causes arthralgia, and the one of the symptoms such as limitation of activity
Kind disease.
Therefore for treating osteoproliferation, diagnosis and treatment based on an overall analysis of the illness and the patient's condition is particularly important, and liver-kidney yin deficiency osteoproliferation belongs to sclerotin
A kind of typical card type of hyperplasia is more common in the ferritic deficiency of Yin or excess of sexual intercourse,indulgence in sexual activities, yin essence loss person.It is partially thin to show as body, Bones and joints
Disease place pain, locally there is burning heat sensation, obtains hot then pain increasing, obtains cold, subtract bitterly, joint joint stuffiness or even joint deformity or tetanic,
Flushed face, dry lip bitter taste, two are just short of, or with dizziness and tinnitus, soreness of waist and knee, have the fidgets, night sleep it is not firm, the red tongue fur of tongue it is few or
Crimson tongue, stringy,thready and rapid pulse.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of with strong points, at low cost, and quick, cure rate is high, nontoxic
The Chinese medicine of the special treatment liver-kidney yin deficiency osteoproliferation of side effect.
The technical scheme is that being achieved:A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, including it is following
The medicine preparation of parts by weight forms:The eclipta of 9-15 parts by weight, the Rehmannia glutinosa of 9-15 parts by weight, 6-12 parts by weight
Radix Paeoniae Alba, the mulberry fruit of 9-15 parts by weight, the jujube of 9-15 parts by weight.
What technical solution of the present invention can be realized in:
A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, the medicine preparation including following parts by weight form:12 parts by weight
Several ecliptas, the Rehmannia glutinosa of 12 parts by weight, the Radix Paeoniae Alba of 9 parts by weight, the mulberry fruit of 12 parts by weight, 12 parts by weight it is big
Jujube.
The preparation method of Chinese medicine of the invention is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
Application method:Daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs
It takes 3-6 months.
The pharmacology of specific each drug ingedient is as follows:
Eclipta:It is sweet, sour, it trembles with fear;It is nourishing liver and kidney, cooling blood and hemostasis.
Rehmannia glutinosa:It is sweet, tepor;Nourishing yin and supplementing blood, beneficial to spirit and marrow.
Radix Paeoniae Alba:Bitter, acid, it is slightly cold;Middle analgesic, contagious yin are delayed in nourishing blood and liver.
Mulberry fruit:It is sweet, sour, it trembles with fear;It enriches blood enriching yin, fluid dryness.
Jujube:Sweet, warm;Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.
It function of the invention and cures mainly:Eclipta embodies we using enriching yin and nourishing kidney as the main of main direction in the present invention
The rules for the treatment of are monarch drug in a prescription;The effect of Rehmannia glutinosa auxiliary eclipta reinforces its enriching yin and nourishing kidney, is ministerial drug;Radix Paeoniae Alba, mulberry fruit Papillary are enriched blood
Nourishing the liver is adjutant;Jujube not only coordinating the drug actions of a prescription, to make medicine, the effect of prescription blood-nourishing can also be reinforced.
The effect of playing enriching yin and nourishing kidney, replenishing blood and nourishing liver altogether after all medicine collaborations.Though each drug of we plays enriching yin and nourishing kidney jointly, mends
The effect of blood nourishing the liver, but emphasize particularly on different fields again, above-mentioned effect can be just played after all medicines share.Such as in we, mulberry fruit not only may be used
The effect of to have shared replenishing blood and nourishing liver with Radix Paeoniae Alba, moreover it is possible to reinforce the effect of the enriching yin and nourishing kidney of monarch drug in a prescription ministerial drug, and if with its other medicine
The effect of object can then weaken the effect of entire prescription enriching yin and nourishing kidney or weaken replenishing blood and nourishing liver.
Beneficial effects of the present invention:For the present invention according to traditional Chinese medical theory, theoretical using diagnosis and treatment carries out Chinese prescription
Screening, formula is scientific and reasonable, and configuration is simple, has no toxic side effect, curative effect is short, quick.We are with enriching yin and nourishing kidney, replenishing blood and nourishing liver
Principle of reatment is first to cure mainly its root with enriching yin and nourishing kidney for the patient of liver-kidney yin deficiency osteoproliferation, supplemented by replenishing blood and nourishing liver,
Perfect square has the effect of enriching yin and nourishing kidney, replenishing blood and nourishing liver.
Specific embodiment
The present invention is described in further details with reference to embodiments:
Embodiment 1:A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation is formed by the medicine preparation of following weight grams:9 grams
Eclipta, 9 grams of Rehmannia glutinosa, 6 grams of Radix Paeoniae Alba, 9 grams of mulberry fruit, 9 grams of jujube.
The preparation method for treating the Chinese medicine of liver-kidney yin deficiency osteoproliferation is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
Application method:Daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs
It takes 3-6 months.
Embodiment 2:A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, by the medicine preparation of following weight grams
At:15 grams of eclipta, 15 grams of Rehmannia glutinosa, 12 grams of Radix Paeoniae Alba, 15 grams of mulberry fruit, 15 grams of jujube.
The preparation method for treating the Chinese medicine of liver-kidney yin deficiency osteoproliferation is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
Application method:Daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs
It takes 3-6 months.
Embodiment 3:A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, by the medicine preparation of following weight grams
At:12 grams of eclipta, 12 grams of Rehmannia glutinosa, 9 grams of Radix Paeoniae Alba, 12 grams of mulberry fruit, 12 grams of jujube.
The preparation method for treating the Chinese medicine of liver-kidney yin deficiency osteoproliferation is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
Application method:Daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs
It takes 3-6 months.
Embodiment 4:A kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, by the medicine preparation of following weight grams
At:10 grams of eclipta, 10 grams of Rehmannia glutinosa, 10 grams of Radix Paeoniae Alba, 10 grams of mulberry fruit, 10 grams of jujube.
The preparation method for treating the Chinese medicine of liver-kidney yin deficiency osteoproliferation is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
Application method:Daily one pair of medicine, every pair of medicine can be decocted three times, be taken in three times, and early, middle and late once a dose before meals.It needs
It takes 3-6 months.
The result of clinical observation of the present invention is as follows:
Effective cure rate of Chinese medicine of the invention counts, and criterion of therapeutical effect is as follows:
It cures:Symptom, sign disappear;
Effectively:Symptom, sign disappearance make moderate progress;
In vain:Symptom, sign are without change.
The present invention treats patient totally 54 of the liver-kidney yin deficiency osteoproliferation for participating in statistics, wherein:Recovery from illness 38, effectively
12, invalid 4, total effective rate reaches 92% or more.
Typical case:
Journey so-and-so, male, 37 years old, difficulty was bent and stretched in soreness and weakness of waist and knees, joint, and insomnia and dreamful sleep is treated by here, was fully recovered after four months.
Claims (3)
1. a kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation, it is characterised in that:Medicine preparation including following parts by weight
It forms:The eclipta of 9-15 parts by weight, the Rehmannia glutinosa of 9-15 parts by weight, the Radix Paeoniae Alba of 6-12 parts by weight, 9-15 parts by weight
Several mulberry fruits, the jujube of 9-15 parts by weight.
2. a kind of Chinese medicine for treating liver-kidney yin deficiency osteoproliferation according to claim 1, it is characterised in that:Including following
The medicine preparation of parts by weight forms:The eclipta of 12 parts by weight, the Rehmannia glutinosa of 12 parts by weight, the Radix Paeoniae Alba of 9 parts by weight,
The mulberry fruit of 12 parts by weight, the jujube of 12 parts by weight.
3. a kind of preparation method of the Chinese medicine for the treatment of liver-kidney yin deficiency osteoproliferation as claimed in claim 1 or 2, preparation side
Method is as follows:
Step 1:Eclipta is cleaned, undesirable root is removed, cleans bored, dissection is dried, spare;
Step 2:Radix Paeoniae Alba is separated into size, is soaked in water to eighty per cant thoroughly, pulls out, solarization is dried in the air, profit to uniform humidity inside and outside, slice,
It is dry, it is spare;
Step 3:By mulberry fruit, jujube(Stoning)Removal of impurities is cleaned, is dried, spare;
Step 4:It will change after small fire decocts 20-30 minutes after being fried boiling Step 1: stock of drugs adds suitable quantity of water to set in casserole in two, three
Cease fire, pulling the dregs of a decoction out is patent medicine.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1788754A (en) * | 2004-12-13 | 2006-06-21 | 河北省中医药研究院高血压糖尿病研究所 | Oral medicine for treating hyperosteogeny-pellet for treating bone pain |
CN102078586A (en) * | 2010-10-08 | 2011-06-01 | 刘淑平 | Medicament for treating cervical spondylosis |
CN104225566A (en) * | 2014-09-29 | 2014-12-24 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula aiming at osteoproliferation |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1788754A (en) * | 2004-12-13 | 2006-06-21 | 河北省中医药研究院高血压糖尿病研究所 | Oral medicine for treating hyperosteogeny-pellet for treating bone pain |
CN102078586A (en) * | 2010-10-08 | 2011-06-01 | 刘淑平 | Medicament for treating cervical spondylosis |
CN104225566A (en) * | 2014-09-29 | 2014-12-24 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula aiming at osteoproliferation |
Non-Patent Citations (1)
Title |
---|
郭美,编著: "《养骨就是养命》", 30 September 2014, 中国医药科技出版社 * |
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Application publication date: 20181127 |