CN108888541A - A kind of skin care compositions and methods and preparation method thereof - Google Patents
A kind of skin care compositions and methods and preparation method thereof Download PDFInfo
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- CN108888541A CN108888541A CN201810704606.1A CN201810704606A CN108888541A CN 108888541 A CN108888541 A CN 108888541A CN 201810704606 A CN201810704606 A CN 201810704606A CN 108888541 A CN108888541 A CN 108888541A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Abstract
The present invention discloses a kind of skin care compositions and methods, weight percentage, including：Film forming agent 1%~20%, thickener 0.5%~10%, plasticizer 0.5%~10%, bacteriostatic agent 0.01%~2%, skin conditioner 0.01%~2% and balance of solvent.Rationally, preparation cost is cheap, easy to use for the formula collocation of skin care compositions and methods of the invention, it is applied directly on skin that the transparent membrane with suitable intensity and toughness can be formed, comfort is good, no tight feeling, the case where facilitating observation to be capped skin wound, to treat in time.The skin care compositions and methods also have good moisture-proof, rub resistance, water resistance and biocidal property; it can play a very good protection to skin; skin is isolated with external environment; prevent wound inflammation and infected; the risk that the surface of a wound further deteriorates is reduced, surface of a wound moisture loss can be also prevented, maintains the surface of a wound wet; conducive to wound healing, and it is able to satisfy the requirement that the short time in wet environment uses.
Description
Technical field
The present invention relates to a kind of skin nursing products more particularly to a kind of skin care compositions and methods and preparation method thereof.
Background technique
Skin is covered on human body outermost, is the maximum organ of human body, accounts for about the 15% of human body weight.Skin is made with barrier
With can protect the stabilization of human internal environment, prevent the invasion of extraneous harmful substance.In life, often there is the case where skin damage
Occur, such as：Burn and scald, acute and chronic skin ulcer, scuffing, scratch and wound etc..When skin damage, due to without skin
The protection of skin, epidermis tissue below are easy to that surface of a wound sense can be increased by the invasion of the various unfavorable factors such as extraneous bacterium
Dye, if processing is not in time, also will cause the risk of amputation to cause wound inflammation, suppuration etc..Currently, skin on the market
Care product contributes to improve the cosmetics of healthy skin appearance, such as moisturizing, the skin nursing of anti-acne and whitening type
Product, there are no the care products for damage skin or delicate skin.Therefore, it needs to develop a kind of for damage skin or crisp
The care product of weak skin.
Summary of the invention
The shortcomings that it is an object of the invention to overcome the above-mentioned prior art and deficiency, provide a kind of skin care compositions and methods and
Preparation method, the skin care compositions and methods can be formed after being applied on skin with rub resistance, moisture-proof, water resistance, suppression
The transparent membrane of bacterium property and suitable intensity and toughness, makes the surface of a wound be isolated from the outside, and prevents trauma surface infestation, inflammation and suppuration, also
Surface of a wound moisture loss can be prevented, maintains the surface of a wound wet, is conducive to wound healing.
To reach its purpose, the technical scheme adopted by the invention is as follows：A kind of skin care compositions and methods, by weight percentage contain
Meter, including：Film forming agent 1%~20%, thickener 0.5%~10%, plasticizer 0.5%~10%, bacteriostatic agent 0.01%~
2%, skin conditioner 0.01%~2% and balance of solvent.
Preferably, weight percentage, the skin care compositions and methods include：Film forming agent 5%~10%, thickener
3%~5%, plasticizer 3%~5%, bacteriostatic agent 0.5%~1%, skin conditioner 0.5%~1% and balance of solvent.When this
When the skin care compositions and methods of invention are prepared by the formula ratio, it both can guarantee that having for skin care compositions and methods obtained was good
Mechanical performance, biocidal property, moisture-proof and water resistance etc., and its preparation cost can be reduced.
Preferably, the film forming agent is polyvinyl formal.Polyvinyl formal is as film forming agent, with skin of the present invention
After other ingredients compounding of skin care composition, there is good durability, hygroscopicity, warmth retention property, erosion resistant and sunlight resistance.
Preferably, the thickener is rosin, rosin ester, hydrogenated rosin, maleic rosin, ethyl cellulose and acrylic acid tree
At least one of rouge.
Preferably, the plasticizer is phthalic easter plastizer, citric acid ester plasticizer, fatty group dibasic acid
At least one of class plasticizer and polyalcohol ester plasticizer.
It is furthermore preferred that the phthalic easter plastizer includes misery 13 ester of O-phthalic, phthalic acid fourth ten
Four esters, capryl octyl phthalate, BBP(Butyl Benzyl Phthalate, dimethoxyethyl phthalate and butyl O-phthalic
At least one of acyl group butyl glycolate.
It is furthermore preferred that the citric acid ester plasticizer includes tributyl citrate, tributyl 2-acetylcitrate and lemon
At least one of triethylenetetraminehexaacetic acid ester.
It is furthermore preferred that the fatty diacid ester plasticizer include succinate, it is glutarate, adipate ester, pungent
At least one of two acid esters, sebacate, dodecanedioic acid ester and tridecanedioate.
It is furthermore preferred that the polyalcohol ester plasticizer include diethylene glycol dibenzoate, dipropylene glycol dibenzoate,
Triethylene-glycol dibenzoate, 2,2,4- trimethyl -1,3- pentanediol-isobutyric acid-benzoic ether, tribenzoin
At least one of with glycerol list lactate tribenzoate.
Film forming agent, thickener and plasticizer of the invention is non-toxic, and resource is sufficient, is easy to get, use cost is low.It is described
The compounding of film forming agent, thickener and plasticizer has suitable toughness so that skin care compositions and methods will form after being applied on skin
With the transparent membrane of intensity, the transparent membrane observes the case where being capped skin convenient for user, convenient for treatment in time.It is described
Transparent membrane also has moisture-proof, rub resistance and water resistance, can effectively prevent the surface of a wound by secondary damage, can also prevent surface of a wound water
Dispersion is lost, and is maintained the surface of a wound wet, is conducive to wound healing.
Preferably, the bacteriostatic agent is tea tree ethereal oil, menthol, menthol, origanum oil, turpentine oil and plant polyphenol kind
Close at least one of object.
Most preferably, weight percentage of the bacteriostatic agent in the skin care compositions and methods is 0.5%.
Preferably, the plant polyphenol kind compound is flavones, isoflavones, flavonols, flavanones, flavanols, flavanones
Alcohol, chalcone, rutin sophorin, hesperidin, quercimentin, green tea polyphenols, pattern glucosides, pattern thuja acid, glycyrrhizin, dihydroquercetin, two
Hydrogen morin, apiolin, sweet-scented osmanthus element, Kaempferol, Quercetin, quercitin, Puerarin, daidzin, daidzein, pterocarpin, safflower
Glycosides, sulphuretin, Cyanidin, delphinidin, pelargonin, catechin, coumaric acid, phloretin, phloridzin, tea polyphenols,
Grape procyanidins, resveratrol, chlorogenic acid, gallic acid, apple polyphenol, ellagic acid, proanthocyanidin, galla turcica tannin and Ellagitannins
At least one of.
Preferably, the skin conditioner is vitamin A, carrotene, carotenoid, vitamin E, vitamin E derive
At least one of object and esterification vitamin C.
Bacteriostatic agent of the invention is the extract of natural plants, and Nantural non-toxic has broad-spectrum antibacterial performance.In the skin
The bacteriostatic agent and skin conditioner are added in care composition, wound healing can be effectively facilitated, enhances the resistance of skin, also
It can further prevent wound is infected to deteriorate, prevent wound inflammation and suppuration.
Preferably, the solvent is at least one of ethyl alcohol, isopropanol, propyl alcohol and hexamethyldisiloxane.Of the invention
Solvent and other components have good intermiscibility, keep the stability of skin care compositions and methods good.
Above-mentioned formula based on the skin care compositions and methods, when selecting different usage ratios between the component to formula
When collocation, the skin care compositions and methods can be made to different dosage forms.Preferably, the dosage form of the skin care compositions and methods is
Solution, lotion, spraying or lotion.
Preferably, the preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticising
Agent, bacteriostatic agent and skin conditioner sequentially add in solvent, heating water bath at 50~80 DEG C, and stirring is to being uniformly dispersed.
Beneficial effects of the present invention are：Rationally, preparation cost is cheap for the formula collocation of skin care compositions and methods of the invention,
It is easy to use, it is applied directly on skin that the transparent membrane with suitable intensity and toughness can be formed, comfort is good, nothing
Tight feeling facilitates the case where observing capped skin wound, to treat in time.The skin care compositions and methods also have well
Moisture-proof, rub resistance, water resistance and biocidal property, can play a very good protection to skin, make skin and external environment
Isolation prevents wound inflammation and infected, reduces the risk that the surface of a wound further deteriorates, can also prevent surface of a wound moisture loss, maintains
The surface of a wound is wet, is conducive to wound healing, and is able to satisfy the requirement that the short time in wet environment uses.
Specific embodiment
More clearly to state technical solution of the present invention, further illustrate combined with specific embodiments below, but cannot use
In the limitation present invention, this is only section Example of the invention.
Embodiment 1
The present embodiment 1 provides a kind of skin care compositions and methods, weight percentage, including：Film forming agent 1%, thickening
Agent 0.5%, plasticizer 0.5%, bacteriostatic agent 2%, skin conditioner 2% and balance of solvent.
The film forming agent is polyvinyl formal；The thickener is rosin and rosin ester；The plasticizer is benzene two
Formate ester plasticizer, specifically, the phthalic easter plastizer is misery 13 ester of O-phthalic；The bacteriostatic agent is
Tea tree ethereal oil and plant polyphenol kind compound, specifically, the plant polyphenol kind compound of the present embodiment is flavones and isoflavones；Institute
Stating skin conditioner is vitamin A and carrotene；The solvent is ethyl alcohol.
The preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticizer, antibacterial
Agent and skin conditioner sequentially add in solvent, heating water bath at 50 DEG C, and stirring is to being uniformly dispersed.
Embodiment 2
The present embodiment 2 provides a kind of skin care compositions and methods, weight percentage, including：Film forming agent 5%, thickening
Agent 3%, plasticizer 3%, bacteriostatic agent 1%, skin conditioner 1% and balance of solvent.
The film forming agent is polyvinyl formal；The thickener is hydrogenated rosin；The plasticizer is citrate
Class plasticizer, specifically, the citric acid ester plasticizer is tributyl citrate；The bacteriostatic agent is origanum oil；The skin
Skin regulator is carotenoid and vitamin E；The solvent is isopropanol.
The preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticizer, antibacterial
Agent and skin conditioner sequentially add in solvent, heating water bath at 60 DEG C, and stirring is to being uniformly dispersed.
Embodiment 3
The present embodiment 3 provides a kind of skin care compositions and methods, weight percentage, including：Film forming agent 10%, thickening
Agent 5%, plasticizer 5%, bacteriostatic agent 0.5%, skin conditioner 0.5% and balance of solvent.
The film forming agent is polyvinyl formal；The thickener is maleic rosin；The plasticizer is aliphatic two
First acid ester type plasticizer, specifically, the fatty diacid ester plasticizer is dodecanedioic acid ester；The bacteriostatic agent is pine
Fuel-economizing and plant polyphenol kind compound, specifically, the plant polyphenol kind compound is green tea polyphenols, pattern glucosides and root skin
Glycosides；The skin conditioner is esterification vitamin C and vitamin e derivative；The solvent is propyl alcohol.
The preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticizer, antibacterial
Agent and skin conditioner sequentially add in solvent, heating water bath at 70 DEG C, and stirring is to being uniformly dispersed.
Embodiment 4
The present embodiment 4 provides a kind of skin care compositions and methods, weight percentage, including：Film forming agent 15%, thickening
Agent 8%, plasticizer 8%, bacteriostatic agent 0.1%, skin conditioner 0.1% and balance of solvent.
The film forming agent is polyvinyl formal；The thickener is ethyl cellulose；The plasticizer is polyalcohol
Ester plasticizer, specifically, the polyalcohol ester plasticizer is diethylene glycol dibenzoate；The bacteriostatic agent is tea tree ethereal oil
And menthol；The skin conditioner is vitamin A and vitamin e derivative；The solvent is hexamethyldisiloxane.
The preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticizer, antibacterial
Agent and skin conditioner sequentially add in solvent, heating water bath at 75 DEG C, and stirring is to being uniformly dispersed.
Embodiment 5
The present embodiment 5 provides a kind of skin care compositions and methods, weight percentage, including：Film forming agent 20%, thickening
Agent 10%, plasticizer 10%, bacteriostatic agent 0.01%, skin conditioner 0.01% and balance of solvent.
The film forming agent is polyvinyl formal；The thickener is acrylic resin；The plasticizer is polyalcohol
Ester plasticizer, specifically, the polyalcohol ester plasticizer is glycerol list lactate tribenzoate；The bacteriostatic agent is thin
The pure and mild plant polyphenol kind compound of lotus, specifically, the plant polyphenol kind compound is coumaric acid and grape procyanidins；The skin tune
Saving agent is carrotene and vitamin E；The solvent is ethyl alcohol.
The preparation method of the skin care compositions and methods, includes the following steps：By film forming agent, thickener, plasticizer, antibacterial
Agent and skin conditioner sequentially add in solvent, heating water bath at 80 DEG C, and stirring is to being uniformly dispersed.
Experimental example
Respectively using the skin care compositions and methods of Examples 1 to 5 as sample liquid, following tests is carried out：
One, biocidal property is tested
By Candida albicans (ATCC14053), Escherichia coli (ATCC25922), staphylococcus aureus (ATCC6538),
Pseudomonas aeruginosa (ATCC27853), aspergillus niger (ATCC16404), bacillus subtilis (ATCC6633) are respectively respectively right
It crosses on the solid plate answered, for 24 hours in 37 ± 1 DEG C of cultures, fungi is in 28 ± 1 DEG C of culture 48h for bacterium.Then picking single colonie,
It is inoculated in the fluid nutrient medium of 3~5mL, microbionation is inoculated in potato glucose in pancreas junket soya peptone culture medium, mould
Culture medium.Bacterium is in 37 ± 1 DEG C, and fungi in 28 ± 1 DEG C, stay overnight by 220r/min shake culture.By 1%~2% volume ratio
The bacterium solution of overnight incubation is inoculated in suitable corresponding fluid nutrient medium, 3h is shaken, works as OD600When=0.6-0.8,
Carry out bacteriostatic test.
By bacterium solid medium heating and melting corresponding with fungi, when culture medium temperature is down to 45 DEG C or so,
Each bacterium of logarithmic phase and fungi are mixed by 2% inoculum concentration with corresponding culture medium, pour plate is put after plate solidification
Enter cooling preservation in 4 DEG C of refrigerators.Then it is punched with 2.7mm diameter punch, the sample liquid of 10 μ L is injected in every hole, and control group is added
Sterile water.Every group three parallel, is inverted in culture dish, 37 ± 1 DEG C of bacterium, 28 ± 1 DEG C of overnight incubations of fungi.It is big according to inhibition zone
Small calculating bacteriostasis rate.The results are shown in Table 1.
Table 1
It can be seen that from the result of table 1, the skin care compositions and methods of the embodiment of the present invention all have preferable bacteriostasis property.
Two, safety evaluatio
Taking weight is the SPF grade kunming mice of (18 ± 2) g, using 8% sodium sulfide solution as depilatory agent, is carried on the back to mouse
Portion carries out depilation processing, and the hair and depilatory agent taken off are washed away with warm water.Sample liquid is applied to depilation position, every 200 μ of mouse
L is applied once daily, continuous to apply one week and observe, and evaluates its safety.As a result, during the whole test process and after the test,
All mouse skins for participating in test without there is any allergic phenomena, illustrate skin care compositions and methods of the invention to skin temperature
With it is non-stimulated.
Three, resistance bacterium test
The staphylococcus aureus frozen is recovered, is crossed to plate, 37 DEG C of growth 48h, picking colony is in TSB (pancreas egg
White peptone soybean broth, tryptic soy broth) in fluid nutrient medium, 37 DEG C, 130r/min concussion is incubated overnight, and the 2nd is again
Renewed vaccination is into new TSB culture medium；When bacterium length to logarithmic phase, medium centrifugal is taken, 6000r/min, 15min are used
Sterile PBS quick wash 2 times, then suspended bacterial to 109CFU/mL.Simultaneously by the inoculum of logarithmic phase with sterile PBS
Buffer gradient dilution, coated plate count bacterium colony number, calculate practical infection dosage.
8 week old are randomly divided into six groups, 5 realities after the SPF grade kunming mice of weight (18 ± 2) g adapts to raising three days
Test group and 1 control group, each 6.1.0% yellow Jackets of every mouse injection 0.1mL before experiment, to its holonarcosis
Afterwards, it uses beeswax depilatory cream to remove coat among back of mice backbone as Test sites, after alcohol disinfecting, cuts off on the skin
The wound of 3cm long, then suture, after alcohol disinfecting, the suture of experimental group smears sample liquid 0.1mL respectively, is formed to its solidification
After film, then smear staphylococcus aureus 0.1mL；Control group directly smears staphylococcus aureus in suture.It sees daily
Situations such as examining redness, the inflammation of mouse damaged zone skin is observed continuously 14 days.The results are shown in Table 2：
Table 2
The result from table 2 can prevent as it can be seen that skin care compositions and methods of the invention can effectively obstruct bacterium infection wound
Only wound inflammation and deterioration are conducive to wound healing.
Four, water vapour permeability test
The sample liquid for measuring 15mL, is cast and is laid on 7cm*11.5cm transparency glass plate, is placed in 50 DEG C of baking ovens
Dry 30min takes out, takes film off from glass plate, weigh 0.5g film, and being covered on the bottle mouth positions of open bottles, (area is
1.77cm2), the anhydrous CaCl of 10g is wherein contained in bottle2, with polytetrafluoroethylene tape that bottleneck is sealed around；Positive controls are adopted
With the bottle of sealing, the anhydrous CaCl of 10g is contained in bottle2；Negative control group using opening bottle, in bottle containing 10g without
Water CaCl2；Every group is done three in parallel.All bottles are placed in drier, saturation NaCl solution is wherein contained in drier
(its relative humidity is 70%RH), drier is placed in 37 DEG C of baking ovens, in the quality of certain time interval measurement bottle, meter
Water vapour permeability is calculated, the results are shown in Table 3.
Table 3
| Test group | Water vapour permeability (g/m2*24h) |
| Positive controls | 30±2.56 |
| Embodiment 1 | 532±1.35 |
| Embodiment 2 | 548±5.62 |
| Embodiment 3 | 568±2.36 |
| Embodiment 4 | 579±2.58 |
| Embodiment 5 | 603±3.58 |
| Negative control group | 8635±3.12 |
As can be seen from result of Table 3, compared with negative control group, skin care compositions and methods of the invention can be effectively reduced
Thus water vapour permeability illustrates that skin care compositions and methods of the invention, which are formed by film, can prevent moisture loss, maintain wound
Face is wet.
Five, rub resistance is tested
Under room temperature (20 DEG C), the skin care compositions and methods of Examples 1 to 5 are applied on transparency glass plate respectively, are made
It forms a film, and then does Mechanical course reciprocating friction with dry hospital gauze and wet hospital gauze respectively, and record causes hole
Rubbing number.Test result shows that the dry friction number for the monofilm that the skin care compositions and methods of Examples 1 to 5 obtain is big
In 1000 times, wet friction number is all larger than 50 times, and respectively in triplicate, test result is all the same, illustrates skin shield of the invention
Reason composition has good rub resistance and is able to satisfy the requirement that the short time in wet environment uses.
Six, stretch-resistance is tested
Under room temperature (20 DEG C), the skin care compositions and methods of Examples 1 to 5 are applied on transparency glass plate respectively, are made
It forms a film, and then removes film, with the free end of fixture clamping film, the breaking strength of other end puller system test film and
Elongation at break, test result show that the breaking strength for the monofilm that the skin care compositions and methods of Examples 1 to 5 obtain is big
In 5N, elongation at break is all larger than 50%, and test is in triplicate, as a result all the same.Illustrate skin care compositions and methods of the invention
With certain intensity and ductility, it is applied on skin and easily forms complete film, no tight feeling.
Finally it should be noted that the above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof.To the greatest extent
Invention is explained in detail referring to above-described embodiment for pipe, those of ordinary skills in the art should understand that：Still
It can be with modifications or equivalent substitutions are made to specific embodiments of the invention, and without departing from any of spirit and scope of the invention
Modification or equivalent replacement, are intended to be within the scope of the claims of the invention.
Claims (10)
1. a kind of skin care compositions and methods, which is characterized in that weight percentage, including：Film forming agent 1%~20% increases
Thick dose 0.5%~10%, plasticizer 0.5%~10%, bacteriostatic agent 0.01%~2%, skin conditioner 0.01%~2% and molten
Agent surplus.
2. skin care compositions and methods as described in claim 1, which is characterized in that the film forming agent is polyvinyl formal.
3. skin care compositions and methods as described in claim 1, which is characterized in that the thickener is rosin, rosin ester, hydrogenation
At least one of rosin, maleic rosin, ethyl cellulose and acrylic resin.
4. skin care compositions and methods as described in claim 1, which is characterized in that the plasticizer is Phthalates plasticising
At least one of agent, citric acid ester plasticizer, fatty diacid ester plasticizer and polyalcohol ester plasticizer.
5. skin care compositions and methods as described in claim 1, which is characterized in that the bacteriostatic agent be tea tree ethereal oil, menthol,
At least one of menthol, origanum oil, turpentine oil and plant polyphenol kind compound.
6. skin care compositions and methods as claimed in claim 5, which is characterized in that the plant polyphenol kind compound be flavones,
Isoflavones, flavonols, flavanones, flavanols, flavanonol, chalcone, rutin sophorin, hesperidin, quercimentin, green tea polyphenols, pattern
Glucosides, pattern thuja acid, glycyrrhizin, dihydroquercetin, dihydromorin, apiolin, sweet-scented osmanthus element, Kaempferol, Quercetin, quercitrin
Glycosides, Puerarin, daidzin, daidzein, pterocarpin, carthamic acid, sulphuretin, Cyanidin, delphinidin, pelargonin, youngster
Theine class, coumaric acid, phloretin, phloridzin, tea polyphenols, grape procyanidins, resveratrol, chlorogenic acid, gallic acid, apple polyphenol,
At least one of ellagic acid, proanthocyanidin, galla turcica tannin and Ellagitannins.
7. skin care compositions and methods as described in claim 1, which is characterized in that the skin conditioner is vitamin A, Hu Luo
At least one of Bu Su, carotenoid, vitamin E, vitamin e derivative and esterification vitamin C.
8. skin care compositions and methods as described in claim 1, which is characterized in that the solvent be ethyl alcohol, isopropanol, propyl alcohol and
At least one of hexamethyldisiloxane.
9. skin care compositions and methods as described in any one of claims 1 to 8, which is characterized in that the skin care compositions and methods
Dosage form be solution, lotion, spraying or lotion.
10. the preparation method of skin care compositions and methods as described in any one of claims 1 to 9, which is characterized in that including as follows
Step：Film forming agent, thickener, plasticizer, bacteriostatic agent and skin conditioner are sequentially added in solvent, water-bath adds at 50~80 DEG C
Heat, stirring is to being uniformly dispersed.
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