CN108884076B - 使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 - Google Patents

使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 Download PDF

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CN108884076B
CN108884076B CN201680078780.9A CN201680078780A CN108884076B CN 108884076 B CN108884076 B CN 108884076B CN 201680078780 A CN201680078780 A CN 201680078780A CN 108884076 B CN108884076 B CN 108884076B
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multiple sclerosis
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CN108884076A (zh
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T·德罗瓦德
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CN201680078780.9A 2015-11-17 2016-11-16 使用具有btk抑制活性的嘧啶和吡啶化合物治疗多发性硬化症的方法 Active CN108884076B (zh)

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US201562256199P 2015-11-17 2015-11-17
US62/256,199 2015-11-17
PCT/US2016/062154 WO2017087445A1 (en) 2015-11-17 2016-11-16 Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity

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CN108884076B true CN108884076B (zh) 2021-07-30

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US10716788B2 (en) 2020-07-21
BR112018007517A2 (pt) 2018-10-23
CA3002224A1 (en) 2017-05-26
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EP4295910A2 (en) 2023-12-27
EP4295910A3 (en) 2024-03-20
BR112018007517B1 (pt) 2023-09-26
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UA123159C2 (uk) 2021-02-24
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US20200316068A1 (en) 2020-10-08
CL2018001252A1 (es) 2018-08-17
SI3377484T1 (sl) 2024-02-29
NZ741294A (en) 2023-07-28
IL258978A (en) 2018-07-31
RU2018120151A3 (enExample) 2020-03-24
RU2018120151A (ru) 2019-12-18
HUE064244T2 (hu) 2024-02-28

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