CN108883368B - 用于处理生物分子的溶液的方法 - Google Patents

用于处理生物分子的溶液的方法 Download PDF

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Publication number
CN108883368B
CN108883368B CN201680083264.5A CN201680083264A CN108883368B CN 108883368 B CN108883368 B CN 108883368B CN 201680083264 A CN201680083264 A CN 201680083264A CN 108883368 B CN108883368 B CN 108883368B
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Prior art keywords
flow
inlet
liquid
flow controller
filtration device
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CN201680083264.5A
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Chinese (zh)
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CN108883368A (zh
Inventor
C.海斯
T.纳吉
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Fujifilm Diosynth Biotechnologies UK Ltd
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Fujifilm Diosynth Biotechnologies UK Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/19—Specific flow restrictors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series
    • B01D2317/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2319/00—Membrane assemblies within one housing
    • B01D2319/02—Elements in series
    • B01D2319/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2008—By influencing the flow statically
    • B01D2321/2016—Static mixers; Turbulence generators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2066—Pulsated flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Extraction Or Liquid Replacement (AREA)
CN201680083264.5A 2016-01-07 2016-12-19 用于处理生物分子的溶液的方法 Active CN108883368B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1600290.9A GB201600290D0 (en) 2016-01-07 2016-01-07 Process
GB1600290.9 2016-01-07
PCT/GB2016/053981 WO2017118836A1 (en) 2016-01-07 2016-12-19 Method for processing solutions of biomolecules

Publications (2)

Publication Number Publication Date
CN108883368A CN108883368A (zh) 2018-11-23
CN108883368B true CN108883368B (zh) 2021-12-31

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US (2) US10682610B2 (https=)
EP (2) EP3400092B1 (https=)
JP (1) JP7080815B2 (https=)
KR (1) KR102794486B1 (https=)
CN (1) CN108883368B (https=)
AU (1) AU2016384286B2 (https=)
CA (1) CA3010545C (https=)
ES (1) ES2971100T3 (https=)
GB (1) GB201600290D0 (https=)
RU (1) RU2750304C2 (https=)
SG (1) SG11201805688XA (https=)
WO (1) WO2017118836A1 (https=)
ZA (1) ZA201804528B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3466432T (lt) 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
GB201600290D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process
GB201802593D0 (en) * 2018-02-16 2018-04-04 Fujifilm Diosynth Biotechnologies Uk Ltd Rig
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法
US20210253633A1 (en) * 2018-06-08 2021-08-19 Bristol-Myers Squibb Company Single pass tangential flow filtration hybrid configurations for enhancing concentration of macromolecule solutions
GB201911686D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying target substances
GB201911685D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying monoclonal antibodies
CN110968509B (zh) * 2019-11-25 2022-11-29 苏宁云计算有限公司 一种批量化自定义变量的方法和系统
GB201918890D0 (en) 2019-12-19 2020-02-05 Ge Healthcare Bio Sciences Ab A bioprocess fluid mixing system
CN114262357B (zh) * 2021-12-29 2023-08-11 浙江旅游职业学院 一种基于ph偏移技术的亚麻蛋白改性设备及方法
CN119173331A (zh) * 2022-03-21 2024-12-20 建新公司 处理流体的方法

Citations (3)

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US4492531A (en) * 1982-04-30 1985-01-08 Kuraray Co., Ltd. Apparatus for producing a controlled pulsed liquid flow
WO2015133972A1 (en) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
WO2015164511A1 (en) * 2014-04-23 2015-10-29 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography

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US3726613A (en) 1970-10-12 1973-04-10 Casimir W Von Pulsefree peristaltic pump
DE2223354A1 (de) 1972-05-12 1973-11-29 Wolf Von Dipl Phys Casimir Verfahren und vorrichtung zur glaettung der foerderleistung von schlauchpumpen
SU1655546A1 (ru) * 1989-06-21 1991-06-15 Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии Установка дл концентрировани культурной жидкости
FR2737261B1 (fr) 1995-07-27 1997-10-10 Jean Francois Ognier Pompe peristaltique
US6011148A (en) 1996-08-01 2000-01-04 Megabios Corporation Methods for purifying nucleic acids
US20040256329A1 (en) 2003-06-13 2004-12-23 Peter Meserol Photodynamic biological fluid pathogen inactivation/filtering apparatus and method
US7384549B2 (en) 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
WO2010090864A2 (en) * 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
US20130040282A1 (en) * 2009-06-15 2013-02-14 Biovec Transfusion, Llc Device and method for removing additives in the blood products
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CN107106701B (zh) 2014-10-03 2020-11-06 西纳福克斯股份有限公司 磺酰胺接头、其缀合物及制备方法
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GB201600290D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process

Patent Citations (3)

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US4492531A (en) * 1982-04-30 1985-01-08 Kuraray Co., Ltd. Apparatus for producing a controlled pulsed liquid flow
WO2015133972A1 (en) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
WO2015164511A1 (en) * 2014-04-23 2015-10-29 Oleg Shinkazh High efficiency continuous countercurrent tangential chromatography

Also Published As

Publication number Publication date
ES2971100T3 (es) 2024-06-03
CA3010545A1 (en) 2017-07-13
RU2018128572A3 (https=) 2020-02-07
US10682610B2 (en) 2020-06-16
AU2016384286B2 (en) 2022-03-17
ZA201804528B (en) 2024-08-28
US20190009215A1 (en) 2019-01-10
SG11201805688XA (en) 2018-07-30
EP3400092C0 (en) 2023-11-22
GB201600290D0 (en) 2016-02-24
RU2750304C2 (ru) 2021-06-25
EP3400092A1 (en) 2018-11-14
EP3400092B1 (en) 2023-11-22
CN108883368A (zh) 2018-11-23
AU2016384286A1 (en) 2018-07-19
JP7080815B2 (ja) 2022-06-06
RU2018128572A (ru) 2020-02-07
EP4273154A3 (en) 2023-12-06
KR20180100411A (ko) 2018-09-10
US20200269190A1 (en) 2020-08-27
WO2017118836A1 (en) 2017-07-13
CA3010545C (en) 2023-10-03
US11439956B2 (en) 2022-09-13
JP2019511453A (ja) 2019-04-25
EP4273154A2 (en) 2023-11-08
KR102794486B1 (ko) 2025-04-11
BR112018013650A2 (pt) 2019-01-22

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