CA3010545C - Method for processing solutions of biomolecules - Google Patents

Method for processing solutions of biomolecules Download PDF

Info

Publication number
CA3010545C
CA3010545C CA3010545A CA3010545A CA3010545C CA 3010545 C CA3010545 C CA 3010545C CA 3010545 A CA3010545 A CA 3010545A CA 3010545 A CA3010545 A CA 3010545A CA 3010545 C CA3010545 C CA 3010545C
Authority
CA
Canada
Prior art keywords
flow
liquid
biomolecule
controller
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3010545A
Other languages
English (en)
French (fr)
Other versions
CA3010545A1 (en
Inventor
Charles HEISE
Tibor Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Diosynth Biotechnologies UK Ltd
Original Assignee
Fujifilm Diosynth Biotechnologies UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Diosynth Biotechnologies UK Ltd filed Critical Fujifilm Diosynth Biotechnologies UK Ltd
Publication of CA3010545A1 publication Critical patent/CA3010545A1/en
Application granted granted Critical
Publication of CA3010545C publication Critical patent/CA3010545C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/16—Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/19—Specific flow restrictors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/02—Elements in series
    • B01D2317/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2319/00—Membrane assemblies within one housing
    • B01D2319/02—Elements in series
    • B01D2319/022—Reject series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2008—By influencing the flow statically
    • B01D2321/2016—Static mixers; Turbulence generators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/20—By influencing the flow
    • B01D2321/2066—Pulsated flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Extraction Or Liquid Replacement (AREA)
CA3010545A 2016-01-07 2016-12-19 Method for processing solutions of biomolecules Active CA3010545C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1600290.9A GB201600290D0 (en) 2016-01-07 2016-01-07 Process
GB1600290.9 2016-01-07
PCT/GB2016/053981 WO2017118836A1 (en) 2016-01-07 2016-12-19 Method for processing solutions of biomolecules

Publications (2)

Publication Number Publication Date
CA3010545A1 CA3010545A1 (en) 2017-07-13
CA3010545C true CA3010545C (en) 2023-10-03

Family

ID=55445684

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3010545A Active CA3010545C (en) 2016-01-07 2016-12-19 Method for processing solutions of biomolecules

Country Status (13)

Country Link
US (2) US10682610B2 (https=)
EP (2) EP3400092B1 (https=)
JP (1) JP7080815B2 (https=)
KR (1) KR102794486B1 (https=)
CN (1) CN108883368B (https=)
AU (1) AU2016384286B2 (https=)
CA (1) CA3010545C (https=)
ES (1) ES2971100T3 (https=)
GB (1) GB201600290D0 (https=)
RU (1) RU2750304C2 (https=)
SG (1) SG11201805688XA (https=)
WO (1) WO2017118836A1 (https=)
ZA (1) ZA201804528B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3466432T (lt) 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
GB201600290D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process
GB201802593D0 (en) * 2018-02-16 2018-04-04 Fujifilm Diosynth Biotechnologies Uk Ltd Rig
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法
US20210253633A1 (en) * 2018-06-08 2021-08-19 Bristol-Myers Squibb Company Single pass tangential flow filtration hybrid configurations for enhancing concentration of macromolecule solutions
GB201911686D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying target substances
GB201911685D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying monoclonal antibodies
CN110968509B (zh) * 2019-11-25 2022-11-29 苏宁云计算有限公司 一种批量化自定义变量的方法和系统
GB201918890D0 (en) 2019-12-19 2020-02-05 Ge Healthcare Bio Sciences Ab A bioprocess fluid mixing system
CN114262357B (zh) * 2021-12-29 2023-08-11 浙江旅游职业学院 一种基于ph偏移技术的亚麻蛋白改性设备及方法
CN119173331A (zh) * 2022-03-21 2024-12-20 建新公司 处理流体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3726613A (en) 1970-10-12 1973-04-10 Casimir W Von Pulsefree peristaltic pump
DE2223354A1 (de) 1972-05-12 1973-11-29 Wolf Von Dipl Phys Casimir Verfahren und vorrichtung zur glaettung der foerderleistung von schlauchpumpen
JPS58190447A (ja) * 1982-04-30 1983-11-07 株式会社クラレ 脈動発生装置
SU1655546A1 (ru) * 1989-06-21 1991-06-15 Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии Установка дл концентрировани культурной жидкости
FR2737261B1 (fr) 1995-07-27 1997-10-10 Jean Francois Ognier Pompe peristaltique
US6011148A (en) 1996-08-01 2000-01-04 Megabios Corporation Methods for purifying nucleic acids
US20040256329A1 (en) 2003-06-13 2004-12-23 Peter Meserol Photodynamic biological fluid pathogen inactivation/filtering apparatus and method
US7384549B2 (en) 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
WO2010090864A2 (en) * 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
US20130040282A1 (en) * 2009-06-15 2013-02-14 Biovec Transfusion, Llc Device and method for removing additives in the blood products
US10265388B2 (en) 2012-02-21 2019-04-23 Cytonics Corporation Systems, compositions, and methods for transplantation
EP2698162A1 (en) 2012-08-15 2014-02-19 Credentis AG Method for producing a composition for treating a tooth lesion
US9533899B2 (en) * 2013-03-12 2017-01-03 General Electric Company Gasification waste water treatment using air separation unit oxygen
EP3113865A4 (en) * 2014-03-07 2017-11-01 Agency For Science, Technology And Research Apparatus and methods for fractionation of biological products
US10324070B2 (en) * 2014-04-23 2019-06-18 Chromatan Inc. High efficiency continuous countercurrent tangential chromatography
CN107106701B (zh) 2014-10-03 2020-11-06 西纳福克斯股份有限公司 磺酰胺接头、其缀合物及制备方法
WO2017062622A1 (en) 2015-10-06 2017-04-13 Massachusetts Institute Of Technology Supramolecular modification of proteins
GB201600290D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process

Also Published As

Publication number Publication date
ES2971100T3 (es) 2024-06-03
CN108883368B (zh) 2021-12-31
CA3010545A1 (en) 2017-07-13
RU2018128572A3 (https=) 2020-02-07
US10682610B2 (en) 2020-06-16
AU2016384286B2 (en) 2022-03-17
ZA201804528B (en) 2024-08-28
US20190009215A1 (en) 2019-01-10
SG11201805688XA (en) 2018-07-30
EP3400092C0 (en) 2023-11-22
GB201600290D0 (en) 2016-02-24
RU2750304C2 (ru) 2021-06-25
EP3400092A1 (en) 2018-11-14
EP3400092B1 (en) 2023-11-22
CN108883368A (zh) 2018-11-23
AU2016384286A1 (en) 2018-07-19
JP7080815B2 (ja) 2022-06-06
RU2018128572A (ru) 2020-02-07
EP4273154A3 (en) 2023-12-06
KR20180100411A (ko) 2018-09-10
US20200269190A1 (en) 2020-08-27
WO2017118836A1 (en) 2017-07-13
US11439956B2 (en) 2022-09-13
JP2019511453A (ja) 2019-04-25
EP4273154A2 (en) 2023-11-08
KR102794486B1 (ko) 2025-04-11
BR112018013650A2 (pt) 2019-01-22

Similar Documents

Publication Publication Date Title
US11439956B2 (en) Method for processing solutions of biomolecules
US11685765B2 (en) Tangential flow filtration process for concentrating biomolecule solutions
KR102867063B1 (ko) 표적물질을 포함하는 액체를 처리하기 위한 장치
RU2824133C2 (ru) Аппарат для обработки жидкости, содержащей целевое вещество
BR112018013650B1 (pt) Aparelho para troca de líquido de um líquido contendo biomolécula, método para a preparação de uma biomolécula
HK40103554A (zh) 用於浓缩生物分子溶液的切向流过滤方法
BR112018013645B1 (pt) Método de concentração de um líquido compreendendo uma biomolécula e processo para a produção de uma biomolécula
BR122024008730A2 (pt) Processo para concentrar soluções de biomolécula

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20211123

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20241120

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20241120

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20241120

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20251209

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20251209