CN108853415A - 一种用于治疗缺铁性贫血的膏方及其制备方法 - Google Patents

一种用于治疗缺铁性贫血的膏方及其制备方法 Download PDF

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Publication number
CN108853415A
CN108853415A CN201810731747.2A CN201810731747A CN108853415A CN 108853415 A CN108853415 A CN 108853415A CN 201810731747 A CN201810731747 A CN 201810731747A CN 108853415 A CN108853415 A CN 108853415A
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China
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parts
radix
treating
hypoferric anemia
rhizoma
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CN201810731747.2A
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Inventor
谢胜
刘园园
刘倩
刘礼剑
谢洁如
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First Affiliated Hospital of Guangxi Medical University
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First Affiliated Hospital of Guangxi Medical University
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Priority to CN201810731747.2A priority Critical patent/CN108853415A/zh
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

本发明公开了一种用于治疗缺铁性贫血的膏方，包括以下原料：黄芪份、升麻份、党参份、炙甘草份、苍术份、木香份、陈皮份、柴胡份、当归份、山药份、茯神份、仙茅份、炒白术份、防风份,麦冬份、生麦芽份、白豆蔻份、茯苓份、酒黄精份、木瓜份、桑寄生份、荆芥穗份、枸杞子份、巴戟天份、五味子份、石菖蒲份、熟地份、芡实份、杜仲份、淫羊藿份、阿胶份、鹿角胶份、南山楂份、车前子份、菟丝子份，本发明中含有多味药材，可以对人体进行全面调节，本发明中含有众多药物，相互作用，制成膏后口服后迅速分解吸收，发挥调补脾胃，滋补肝肾，益气生血之效，从而改善患者整体质状态；本发明服用方法简单，口感好，疗效显著，易于被患者接受。

Description

一种用于治疗缺铁性贫血的膏方及其制备方法
技术领域
本发明涉及中医领域，具体是一种用于治疗缺铁性贫血的膏方及其制备方法。
背景技术
缺铁性贫血(Iron deficiency anemia,缺铁性贫血)是最常见的一种营养性贫血，是指由于铁摄入、吸收不足，或需求量增加，或损失过多等原因导致体内贮存铁缺乏，影响血红蛋白合成所引起的一种小细胞低色素型贫血。此病可导致机体抵抗力下降，严重者可并发心脑肾等重要脏器功能衰竭，影响正常工作、学习、生活。世界卫生组织(WHO)报道，全世界约有10％～30％的人群有不同程度的缺铁，并将缺铁性贫血定为世界性疾病，是发展中国家四大营养缺乏症之一。而妇女由于月经、妊娠以及节食瘦身等原因，成为缺铁性贫血的高发人群,2004年中国疾控中心统计，中国有30％人口患有缺铁性贫血。缺铁性贫血的一般表现:乏力、倦怠、头晕、眼花、耳鸣、心悸、气短、纳差等。伴有冠状动脉硬化者，可促发心绞痛，妇女可有闭经、月经不调等，严重者可导致贫血性心脏病，甚至充血性心力衰竭等。缺铁性贫血的治疗目前仍以口服铁剂为一线治疗，但铁剂吸收效率往往不高，加之相当患者服用铁剂出现胃肠道反应，因此口服铁剂通常难以达到理想的效果。祖国医学中的“虚劳”、“眩晕”、“黄肿”、“血虚”、“血枯”类似于现代医学中的缺铁性贫血。《素问·脉要精微论》曰：“脾脉搏坚而长，其色黄，当病少气，其软而散，色不泽者，当病是脂肿，若水状也”。《金匾要略·黄疸病脉证治》：“其腹胀如水状，大便必黑，时溏，此女劳之病，非水也，腹满者难治。摘石巩石散主之”。《圣济总录》“气黄十三”和“痈黄十四”：身如金色，而脚黄肿，心中战悸，不能食，不多言语，四肢无力，好眠卧。《丹溪心法》用大温中丸治食积与“黄肿”。中医认为，脾胃为后天之本，为气血生化之源，肝主藏血，肾主藏精，精血同源，故贫血与脾、肝、肾三脏的功能失调密切相关。常见的症状以乏力、头晕、心悸、气短、面色无华或萎黄等脾气亏虚型最为常见，故脾胃虚弱，运化失常，气血生化乏源是本病发生的基本病机，治疗以健脾养肝补肾等为主。
目前中医治疗缺铁性贫血常用内服中药，如汤剂和丸剂等，而缺铁性贫血属于慢性虚症，短时间服药难以奏效，易复发，汤剂煎煮繁琐、丸剂吸收慢，患者依从性差，疗效欠佳。
发明内容
本发明的目的在于提供一种用于治疗缺铁性贫血的膏方及其制备方法，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种用于治疗缺铁性贫血的膏方，包括以下重量份数的原料：黄芪20-40份、升麻2-8份、党参10-20份、炙甘草10-20份、苍术2-8份、木香5-15份、陈皮10-20份、柴胡2-8份、当归10-20份、山药20-40份、茯神10-20份、仙茅5-15份、炒白术10-20份、防风5-15份,麦冬10-20份、生麦芽10-30份、白豆蔻5-15份、茯苓10-20份、酒黄精10-20份、木瓜10-30份、桑寄生20-40份、荆芥穗2-8份、枸杞子10-30份、巴戟天10-20份、五味子2-8份、石菖蒲5-15份、熟地20-40份、芡实20-40份、杜仲10-20份、淫羊藿10-30份、阿胶2-8份、鹿角胶2-8份、南山楂10-30份、车前子5-15份、菟丝子10-20份、辅料710-1190份、水适量。
作为本发明进一步的方案：所述辅料包括黄酒400-600份、龙眼肉80-120份、白砂糖100-200份、黑芝麻30-70份、核桃仁100-200份。
作为本发明再进一步的方案：包括以下重量份数的原料：黄芪30份、升麻5份、党参15份、炙甘草15份、苍术5份、木香10份、陈皮15份、柴胡5份、当归15份、山药30份、茯神15份、仙茅10份、炒白术15份、防风10份,麦冬15份、生麦芽20份、白豆蔻10份、茯苓15份、酒黄精15份、木瓜20份、桑寄生30份、荆芥穗5份、枸杞子20份、巴戟天15份、五味子5份、石菖蒲10份、熟地30份、芡实30份、杜仲15份、淫羊藿20份、阿胶5份、鹿角胶5份、南山楂20份、车前子10份、菟丝子15份、辅料950份、水适量。
作为本发明再进一步的方案：所述辅料包括黄酒500份、龙眼肉100份、白砂糖150份、黑芝麻50份、核桃仁150份。
作为本发明再进一步的方案：还包括蜂蜜10-20份。
一种用于治疗缺铁性贫血的膏方的制备方法，包括以下步骤：(1)称取各组分原料，备用；(2)将黄芪、升麻、党参、炙甘草、苍术、陈皮、柴胡、当归、山药、茯神、仙茅、炒白术、防风,麦冬、生麦芽、茯苓、酒黄精、木瓜、桑寄生、枸杞子、巴戟天、五味子、熟地、芡实、杜仲、淫羊藿、南山楂、车前子、菟丝子放入水中浸泡10-15h；(3)将以上浸泡后的中药倒入中药机中，加入8-15倍水，煎煮3-6h，煎煮的同时进行搅拌，除去表面泡沫，过滤取出药液；(4)保留药渣，向中药机中倒入8-15倍水，煎煮3-6h，过滤取出药液，重复本步骤3次；(5)将所得的所有药液倒入锅中，加热浓缩至药液原来体积的30-50％，得到浓缩液；(6)将鹿角胶、阿胶分别进行烊化处理；(7)将木香、白豆蔻、荆芥穗、石菖蒲、辅料以及烊化后的鹿角胶、龟甲胶、肉桂依次倒入浓缩液中，文火熬煮2-4h，得到混合液；(8)将混合液用80目筛过筛2-3次，得到混合滤液；(9)将混合滤液用文火熬煮，兑入蜂蜜，熬至膏状即可。
作为本发明进一步的方案：步骤(2)中，浸泡时间为12h。
与现有技术相比，本发明的有益效果是：1、本发明中含有多味药材，可以对人体进行全面调节，2、本发明中含有众多药物，相互作用，制成膏后口服后迅速分解吸收，发挥调补脾胃，滋补肝肾，益气生血之效，从而改善患者整体质状态；3、本发明服用方法简单，口感好，疗效显著，易于被患者接受，有良好的临床疗效及广阔的社会需求，值得临床推广与运用；4、通过大量的临床观察发现通过该药治疗，有效率高，从根本上解决缺铁性贫血易复发弊端。
具体实施方式
下面结合具体实施方式对本专利的技术方案作进一步详细地说明。
实施例1
一种用于治疗缺铁性贫血的膏方，包括以下原料：黄芪20g、升麻2g、党参10g、炙甘草10g、苍术2g、木香5g、陈皮10g、柴胡2g、当归10g、山药20g、茯神10g、仙茅5g、炒白术10g、防风5g,麦冬10g、生麦芽10g、白豆蔻5g、茯苓10g、酒黄精10g、木瓜10g、桑寄生20g、荆芥穗2g、枸杞子10g、巴戟天10g、五味子2g、石菖蒲5g、熟地20g、芡实20g、杜仲10g、淫羊藿10g、阿胶2g、鹿角胶2g、南山楂10g、车前子5g、菟丝子10g、辅料、蜂蜜10g、水适量，其中辅料包括黄酒400g、龙眼肉80g、白砂糖100g、黑芝麻30g、核桃仁100g。
一种用于治疗缺铁性贫血的膏方的制备方法，包括以下步骤：(1)称取各组分原料，备用；(2)将黄芪、升麻、党参、炙甘草、苍术、陈皮、柴胡、当归、山药、茯神、仙茅、炒白术、防风,麦冬、生麦芽、茯苓、酒黄精、木瓜、桑寄生、枸杞子、巴戟天、五味子、熟地、芡实、杜仲、淫羊藿、南山楂、车前子、菟丝子放入水中浸泡10h；(3)将以上浸泡后的中药倒入中药机中，加入8倍水，煎煮3h，煎煮的同时进行搅拌，除去表面泡沫，过滤取出药液；(4)保留药渣，向中药机中倒入8倍水，煎煮3h，过滤取出药液，重复本步骤3次；(5)将所得的所有药液倒入锅中，加热浓缩至药液原来体积的30％，得到浓缩液；(6)将鹿角胶、阿胶分别进行烊化处理；(7)将木香、白豆蔻、荆芥穗、石菖蒲、辅料以及烊化后的鹿角胶、龟甲胶、肉桂依次倒入浓缩液中，文火熬煮2h，得到混合液；(8)将混合液用80目筛过筛2次，得到混合滤液；(9)将混合滤液用文火熬煮，兑入蜂蜜，熬至膏状即可。
实施例2
一种用于治疗缺铁性贫血的膏方，包括以下原料：黄芪40g、升麻8g、党参20g、炙甘草20g、苍术8g、木香15g、陈皮20g、柴胡8g、当归20g、山药40g、茯神20g、仙茅15g、炒白术20g、防风15g,麦冬20g、生麦芽30g、白豆蔻15g、茯苓20g、酒黄精20g、木瓜30g、桑寄生40g、荆芥穗8g、枸杞子30g、巴戟天20g、五味子8g、石菖蒲15g、熟地40g、芡实40g、杜仲20g、淫羊藿30g、阿胶8g、鹿角胶8g、南山楂30g、车前子15g、菟丝子20g、辅料、蜂蜜20g、水适量，其中辅料包括黄酒600g、龙眼肉120g、白砂糖200g、黑芝麻70g、核桃仁200g。
一种用于治疗缺铁性贫血的膏方的制备方法，包括以下步骤：(1)称取各组分原料，备用；(2)将黄芪、升麻、党参、炙甘草、苍术、陈皮、柴胡、当归、山药、茯神、仙茅、炒白术、防风,麦冬、生麦芽、茯苓、酒黄精、木瓜、桑寄生、枸杞子、巴戟天、五味子、熟地、芡实、杜仲、淫羊藿、南山楂、车前子、菟丝子放入水中浸泡15h；(3)将以上浸泡后的中药倒入中药机中，加入15倍水，煎煮6h，煎煮的同时进行搅拌，除去表面泡沫，过滤取出药液；(4)保留药渣，向中药机中倒入15倍水，煎煮6h，过滤取出药液，重复本步骤3次；(5)将所得的所有药液倒入锅中，加热浓缩至药液原来体积的50％，得到浓缩液；(6)将鹿角胶、阿胶分别进行烊化处理；(7)将木香、白豆蔻、荆芥穗、石菖蒲、辅料以及烊化后的鹿角胶、龟甲胶、肉桂依次倒入浓缩液中，文火熬煮4h，得到混合液；(8)将混合液用80目筛过筛3次，得到混合滤液；(9)将混合滤液用文火熬煮，兑入蜂蜜，熬至膏状即可。
实施例3
一种用于治疗缺铁性贫血的膏方，包括以下原料：黄芪30g、升麻5g、党参15g、炙甘草15g、苍术5g、木香10g、陈皮15g、柴胡5g、当归15g、山药30g、茯神15g、仙茅10g、炒白术15g、防风10g,麦冬15g、生麦芽20g、白豆蔻10g、茯苓15g、酒黄精15g、木瓜20g、桑寄生30g、荆芥穗5g、枸杞子20g、巴戟天15g、五味子5g、石菖蒲10g、熟地30g、芡实30g、杜仲15g、淫羊藿20g、阿胶5g、鹿角胶5g、南山楂20g、车前子10g、菟丝子15g、辅料、蜂蜜15g、水适量，其中辅料包括黄酒500g、龙眼肉100g、白砂糖150g、黑芝麻50g、核桃仁150g。
一种用于治疗缺铁性贫血的膏方的制备方法，包括以下步骤：(1)称取各组分原料，备用；(2)将黄芪、升麻、党参、炙甘草、苍术、陈皮、柴胡、当归、山药、茯神、仙茅、炒白术、防风,麦冬、生麦芽、茯苓、酒黄精、木瓜、桑寄生、枸杞子、巴戟天、五味子、熟地、芡实、杜仲、淫羊藿、南山楂、车前子、菟丝子放入水中浸泡12h；(3)将以上浸泡后的中药倒入中药机中，加入10倍水，煎煮5h，煎煮的同时进行搅拌，除去表面泡沫，过滤取出药液；(4)保留药渣，向中药机中倒入10倍水，煎煮5h，过滤取出药液，重复本步骤3次；(5)将所得的所有药液倒入锅中，加热浓缩至药液原来体积的40％，得到浓缩液；(6)将鹿角胶、阿胶分别进行烊化处理；(7)将木香、白豆蔻、荆芥穗、石菖蒲、辅料以及烊化后的鹿角胶、龟甲胶、肉桂依次倒入浓缩液中，文火熬煮3h，得到混合液；(8)将混合液用80目筛过筛3次，得到混合滤液；(9)将混合滤液用文火熬煮，兑入蜂蜜，熬至膏状即可。
实验例1
1、病例选择，患者年龄范围，病程时间
选取广西中医药大学第一附属医院中医治未病中心缺铁性贫血患者100例，随机分为2组。用于治疗缺铁性贫血的膏方组50例患者，其中男22例，女28例；年龄20-55岁，平均(38.56±15.78)岁；病程7月-36月，平均(12.45±5.07)月。西药组50例患者予硫酸亚铁片治疗，其中男27例，女23例；年龄18-55岁，平均(37.08±14.98)岁；病程6月-35月，平均(11.45±4.25)月。
2、诊断标准简介
全部病例西医诊断均符合2007年张之南主编《血液病诊断及疗效标准》的诊断标准。西医诊断标准:①小细胞低色素贫血:男性Hb<120g/L，女性Hb<110g/L，孕妇Hb<100g/L；MCV<80f1,MCH<27pg,MCHC<0.32；红细胞形态可有明显低色素表现。②有明显的缺铁病因和临床表现。③血清(血浆)铁<8.95umol/L，总铁结合力>64.44umol/L。④运铁蛋白饱和度<0.15。⑤骨髓铁染色显示骨髓可染铁消失，铁粒幼红细胞<15％。⑥血清铁蛋白(SF)<12ug/L。⑦铁剂治疗有效。
符合第1条和第2～7条中任何两条以上，可诊断为缺铁性贫血。
3、疗效判定标准：
参照《中药新药临床研究指导原则》的疗效评定标准：采用尼莫地平法计算。疗效指数＝(治疗前积分-治疗后积分)/治疗前积分×100％。①临床痊愈：主要症状、体征消失或基本消失，疗效指数≥95％。②显效：主要症状、体征明显改善，70％≤疗效指数<95％。③有效：主要症状、体征明显好转，30％≤疗效指数<70％。④无效：主要症状，体征无明显改善，甚或加重，疗效指数<30％。
4、药物使用方法
膏方组：予用于治疗缺铁性贫血的膏方治疗，每天2次，每次20ML，温水兑服。
西药组：予硫酸亚铁片0.3g，每天2次。
5、临床治疗结果，以表格形式汇总
5.1两组治疗前后主要症状积分比较，见表1
表1两组治疗前后主要症状积分比较
组别 例数 治疗前 治疗后 疗效指数
西药组 50 13.58±3.42 7.58±1.33*# 0.68±0.13#
膏方组 50 13.31±3.33 4.88±1.16*# 0.83±0.16#
注：与西药组比较：*P<0.05，#P<0.01。治疗后，用于治疗缺铁性贫血的膏方组明显改善患者主要症状(P<0.05)，疗效更确切(P<0.01)。
5.2两组治疗后疗效比较，见表2
表2两组治疗前后疗效比较
组别 例数 痊愈(痊愈率) 显效(显效率) 有效(有效率) 无效(无效率) 总有效率
西药组 50 5(10) 10(20) 20(40) 15(30) 70％
膏方组 50 18(36) 22(44) 7(14) 3(6) 94％
注：与西药组比较：*P<0.01.治疗后，用于治疗缺铁性贫血的膏方组治疗该病较西药组有效(P<0.01)。
临床病例：
病例1：陈×，女，38岁，广西南宁市人，公务员，病程2年，症见疲劳、失眠、记忆力或注意力下降。舌干红，脉弦细。曾于外院住院检查发现缺铁性贫血。口服“硫酸亚铁片0.3gtid”，经治疗2个月病情未见好转；经本发明药物施治，治疗1个月后症状明显缓解，随访半年未见复发。
病例2：张×，女，40岁，广西柳州人，职员，病程10年，症见：疲乏无力，食欲不振，月经量多。舌质淡，苔白，脉细。当地医院住院检查发现缺铁性贫血，口服“硫酸亚铁片0.3gtid”6个月，复查血常规仍轻度贫血，不满意治疗效果，遂到我院就诊，经本发明药物施治，治疗3月后症状明显缓解，随访2年未见复发。
病例3：李×，男，46岁，广西南宁市人，教师，病程3月，痔疮术后，查血常规提示轻度贫血，症见：疲乏无力，睡眠质量欠佳，面色萎黄，口干，舌质淡，苔白，脉细。口服“硫酸亚铁片0.3g tid”2月仍轻度贫血，经本发明药物施治，治疗1月后症状明显缓解，复查血常规未见明显异常。
病例4：陈×，女，55岁，广西柳州人，教师，病程10年，症见：疲乏无力，睡眠质量欠佳，头晕，潮热、目干涩。舌红，少苔，脉沉细。曾在外院住院系统检查，诊断“中度贫血”，予口服“硫酸亚铁片0.3g tid”治疗，不满意治疗效果；经本发明药物施治，治疗6月后症状明显缓解，随访半年未见复发。
病例5：王×，女，49岁，广西玉林市人，工程师，病程3月，症见：疲乏无力，睡眠质量欠佳，头晕、头痛，面色萎黄。舌红少苔，脉细。在我院门诊完善相关检查提示“中度贫血”。口服“硫酸亚铁片0.3g tid”1周后便秘，遂停药。经本发明药物施治，治疗2个月后症状明显缓解，随访半年未见复发，血常规未见明显异常。
上面对本专利的较佳实施方式作了详细说明，但是本专利并不限于上述实施方式，在本领域的普通技术人员所具备的知识范围内，还可以在不脱离本专利宗旨的前提下作出各种变化。

Claims (7)

1.一种用于治疗缺铁性贫血的膏方，其特征在于，包括以下重量份数的原料：黄芪20-40份、升麻2-8份、党参10-20份、炙甘草10-20份、苍术2-8份、木香5-15份、陈皮10-20份、柴胡2-8份、当归10-20份、山药20-40份、茯神10-20份、仙茅5-15份、炒白术10-20份、防风5-15份,麦冬10-20份、生麦芽10-30份、白豆蔻5-15份、茯苓10-20份、酒黄精10-20份、木瓜10-30份、桑寄生20-40份、荆芥穗2-8份、枸杞子10-30份、巴戟天10-20份、五味子2-8份、石菖蒲5-15份、熟地20-40份、芡实20-40份、杜仲10-20份、淫羊藿10-30份、阿胶2-8份、鹿角胶2-8份、南山楂10-30份、车前子5-15份、菟丝子10-20份、辅料710-1190份、水适量。
2.根据权利要求1所述的用于治疗缺铁性贫血的膏方，其特征在于，所述辅料包括黄酒400-600份、龙眼肉80-120份、白砂糖100-200份、黑芝麻30-70份、核桃仁100-200份。
3.根据权利要求1所述的用于治疗缺铁性贫血的膏方，其特征在于，包括以下重量份数的原料：黄芪30份、升麻5份、党参15份、炙甘草15份、苍术5份、木香10份、陈皮15份、柴胡5份、当归15份、山药30份、茯神15份、仙茅10份、炒白术15份、防风10份,麦冬15份、生麦芽20份、白豆蔻10份、茯苓15份、酒黄精15份、木瓜20份、桑寄生30份、荆芥穗5份、枸杞子20份、巴戟天15份、五味子5份、石菖蒲10份、熟地30份、芡实30份、杜仲15份、淫羊藿20份、阿胶5份、鹿角胶5份、南山楂20份、车前子10份、菟丝子15份、辅料950份、水适量。
4.根据权利要求1-3所述的用于治疗缺铁性贫血的膏方，其特征在于，所述辅料包括黄酒500份、龙眼肉100份、白砂糖150份、黑芝麻50份、核桃仁150份。
5.根据权利要求4所述的用于治疗缺铁性贫血的膏方，其特征在于，还包括蜂蜜10-20份。
6.一种用于治疗缺铁性贫血的膏方的制备方法，其特征在于，包括以下步骤：（1）称取各组分原料，备用；（2）将黄芪、升麻、党参、炙甘草、苍术、陈皮、柴胡、当归、山药、茯神、仙茅、炒白术、防风,麦冬、生麦芽、茯苓、酒黄精、木瓜、桑寄生、枸杞子、巴戟天、五味子、熟地、芡实、杜仲、淫羊藿、南山楂、车前子、菟丝子放入水中浸泡10-15h；（3）将以上浸泡后的中药倒入中药机中，加入8-15倍水，煎煮3-6h，煎煮的同时进行搅拌，除去表面泡沫，过滤取出药液；（4）保留药渣，向中药机中倒入8-15倍水，煎煮3-6h，过滤取出药液，重复本步骤3次；（5）将所得的所有药液倒入锅中，加热浓缩至药液原来体积的30-50%，得到浓缩液；（6）将鹿角胶、阿胶分别进行烊化处理；（7）将木香、白豆蔻、荆芥穗、石菖蒲、辅料以及烊化后的鹿角胶、龟甲胶、肉桂依次倒入浓缩液中，文火熬煮2-4h，得到混合液；（8）将混合液用80目筛过筛2-3次，得到混合滤液；（9）将混合滤液用文火熬煮，兑入蜂蜜，熬至膏状即可。
7.根据权利要求6所述的一种用于治疗缺铁性贫血的膏方的制备方法，其特征在于，步骤（2）中，浸泡时间为12h。
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