CN108853319A - A kind of preventing cold, anti-haze clearing lung-heat Chinese medicine composition and preparation method - Google Patents
A kind of preventing cold, anti-haze clearing lung-heat Chinese medicine composition and preparation method Download PDFInfo
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Abstract
The present invention discloses the Chinese medicine composition of a kind of preventing cold, anti-haze clearing lung-heat, it be include following weight proportion Chinese medicine material medicament：475-525 parts of Laiyang pear pastes, 15-20 parts of fritillary bulb powder, 30-40 parts of Honegsukle flower P.Es.The medicament is granule, tablet, block agent or syrup.Invention additionally discloses the preparation methods of the Chinese medicine composition.Chinese medicine composition of the invention is by adjusting each material rate relationship, so that each raw material realizes preferable synergistic function.And drug effect is more lasting, generates unexpected effect in terms of preventing cold, anti-haze clearing lung-heat.
Description
Technical field
It cures cold and the technical field of traditional Chinese medicines of anti-haze the present invention relates to anti-, it is clear more particularly to a kind of preventing cold, anti-haze
The Chinese medicine composition and preparation method of lung.
Background technique
Flu is a kind of most common infectious disease caused by virus.The drug for treating flu has two class of Western medicine and Chinese medicine,
Treat flu Western medicine be usually with injection system come treat flu and have different side effects to human body.Hospital uses prevention sense
The drug emitted is mostly the drug of globulin, influenza vaccines or antibiotic etc to prevent and treat flu, but is preventing and controlling
During treatment patient can occur with complication symptom, increase the pain of patient, in addition these methods are for by newly making a variation
Flu caused by virus strains can lose expected curative effect.Especially there are many patients to be easy repeated cold, two to three when beginning
Recurrence in a month is primary, and subsequent one to two moon recurrence is primary or even morbidity in later 20 to 30 days is primary, mostly using disease-resistant
The antibiotic treatment of malicious class, and it is more further big with antibiotic frequency of disease development, it finally results in germ or virus drug resistance generates.
And currently, obviously increase China's haze day, a large amount of particle, dust, pollution are floated in haze weather, in air
The harmful substances such as object, virus.Once being sucked by human body, the respiratory tract of human body will be damaged, stimulate and destroy respiratory tract
The defence capability of mucous membrane, pathogen enter respiratory tract, be easy to cause the infection of the upper respiratory tract, the serious pneumonia, chronic of also resulting in
The diseases such as obstructive lung disease.For the masses for being subjected to haze weather, initial symptoms are not significant, hospital issue Chinese patent drug or
Cream is inconvenient, and voluntarily takes that some tea-drinkings are different surely to play good anti-haze effect, and therefore, haze can be resisted by studying one kind,
And prescription is safety and low cost, the research of Chinese materia medica preparation convenient to take is particularly important.
Modern pharmacological studies have shown that Chinese medicine, which has respiratory disease caused by flu, haze, preferably prevents and treats curative effect
Fruit.Using Chinese medicine as raw material according to science technique after Preparation process, certain dosage form is made.It provides to have currently on the market and control
It treats majority in flu, the product formula of throat-clearing lung-moistening effect to be made by containing ten multiple medications formulas, ingredient is excessively complicated, no
Conducive to quality control, cost is also difficult to control.And such product generally can just be taken just for the crowd that illness occurs, often
Flavour of a drug weight, entrance is bitter, it is bad to take mouthfeel, and effect is single, is not able to satisfy the demand of different crowd in the market.
Summary of the invention
For above-mentioned defect, the present invention provides the Chinese medicine composition of a kind of preventing cold, anti-haze clearing lung-heat, it is packet
Include the medicament of the Chinese medicine material of following weight proportion：
Laiyang pear paste：475-525 parts；
Fritillary bulb powder：15-20 parts；
Honegsukle flower P.E：30-40 parts；
Auxiliary material：20-30 parts.
Preferably, the weight proportion of the Chinese medicine material is as follows：
Laiyang pear paste：500 parts；
Fritillary bulb powder：17 parts；
Honegsukle flower P.E：35 parts；
Auxiliary material：25 parts.
Specifically, the Chinese medicine composition of preventing cold of the invention, anti-haze clearing lung-heat is granule, tablet or block agent.
The present invention also provides a kind of preventing colds, the Chinese medicine composition of anti-haze clearing lung-heat, it is matched including following weight
The syrup of Chinese medicine material：
Laiyang pear paste：475-525 parts；
Fritillary bulb powder：15-20 parts；
Honegsukle flower P.E：30-40 parts.
The drug action mechanism of each component is as follows in the traditional chinese medicine composition of the invention:
1. pears are had a high regard for as " ancestors of all kinds of fruits " from ancient times.It is sweet in flavor slightly sour, cold in nature nontoxic.It can be with cough-relieving, moistening lung, the cool heart, anti-inflammatory drop
The effect of fire, solution sore.
（1）Clear dry moistening lung, relieving cough and reducing sputum, nourishing blood and promoting granulation
Pear juice it is sweet in flavor acid and put down, play the role of clearly dry moistening lung, relieving cough and reducing sputum, nourishing blood and promoting granulation, therefore to dry throat, itch, pain, sound
It is mute, phlegm is thick etc. good effect.
（2）Yin-nourishing, moisturize, disappear wind
Pears have effects that moistening lung, disappear wind, and when dry, people often feel that pruitus, mouth and nose are dry, and dry cough is few sometimes
Phlegm drinks one two glasss of pear juices daily, can be relieved drying.
（3）Alleviate throat irritation
The people of smoking drinks pear juice, can mitigate stimulation of the harmful substance to throat, respiratory tract in cigarette.
2. fritillary bulb is the dry bulb of liliaceous plant fritillary bulb.Bulb contains peimisine, imperialine, peimine
First, peimine second, peimine third and peimine infantile malnutrition due to digestive disturbances or intestinalparasites.Function with clearing heat and moistening lung, preventing phlegm from forming and stopping coughing is suitable for lung-heat type cough, dry cough
The diseases such as few phlegm, deficiency of Yin labor gargles, cough sputum streaked with blood.
（1）Clearing heat and moistening lung
Fritillary bulb opens the medicine of strongly fragrant, lower gas, resolving sputum.Moistening lung dissolving phlegm, relieving cough and relieving asthma, then the card of consumptive disease fire knot, the department of fritillaria are first
Agent.
（2）Preventing phlegm from forming and stopping coughing
Fritillary bulb, bitter can decline, and micro-pungent energy relieve stagnation, smell is all clear, therefore with cardiopulmonary are entered, cure mainly depressed phlegm, empty phlegm, hot phlegm and phlegm
Very against gas, polydipsia heat, this is thermally conductive not all right for middle band blood, cough due to consumptive disease, chest diaphragm, and mental disorder is certainly sharp.
（3）Dissipating bind disappears carbuncle
Taking its lower benefit, then poison is gone, and then poison solves air-dispersing, and with lung, pulmonary abscess, gall subcutaneous nodule, skin sore is treated, this all opens strongly fragrant dissipating bind, blood vessels
The function of circulation.Its energy drop cool in nature is taken again, is apt to adjust temper, controls flaring up of stomach fire, punching forces lung gold, causes expectoration more than, this clean air enriching yin,
Lung is from rather.
3. honeysuckle, China north and south various regions are distributed, for caprifoliaceae plant honeysuckle dry flower or just open
Flower, the sweet cold air fragrance of property, for clear heat with drugs of sweet flavour and cold nature without injuring one's stomach, fragrance reaches thoroughly again can eliminating evil.Honeysuckle has clearing heat and detoxicating, dispelling wind and heat from the body
Effect, can be used for various febrile diseases, such as the hot dermexanthesis of body, macular eruption, heat toxin sore carbuncle, abscess of throat disease.Honeysuckle in we
The institute place of production should not use other place of production honeysuckles based on the pan honeysuckle flower of Shandong.
（1）Subdhing swelling and detoxicating
Honeysuckle is sweet cold, can be clearing heat and detoxicating, can be used to treat the outer carbuncle of all internal carbuncles.
（2）Dissipate wind-heat
Honeysuckle is sweet cold, fragrance evacuation, is apt to scattered lung channel heat evil, diathermanous to reach table, can be used to treat affection of exogenous wind-heat or warm disease initial stage
When body heat, the diseases such as pharyngalgia is thirsty.
（3）Antibacterial action
Honeysuckle has the antibacterial action of wide spectrum, has stronger inhibiting effect to pathogenic bacteria such as golden yellow coccus, shigella dysenteriaes, right
The multiple pathogenic microorganisms such as Leptospira, influenza virus and pathogenic moulds have inhibiting effect.
（4）Strengthen immunity
Honeysuckle can promote the phagocytic activity of leucocyte, there is strengthen immunity.The chlorogenic acid contained in honeysuckle is raw
Object activity enters after human body the metabolism that can promote body, adjusts function of human body to help to improve the immunity of human body.
In an aspect, provide preventing cold of the invention, anti-haze clearing lung-heat Chinese medicine composition preparation method, including
Following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, crosses 80 meshes, uses 95% by conventional method
The every bagged granules 2.5g/ packet of granule is made in medicinal alcohol；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained granule, and according to content adjustment
The unit dose of granule makes to contain 37.5mg chlorogenic acid and 1.25mg Peininine in every packet granule.
In another aspect, provide preventing cold of the invention, anti-haze clearing lung-heat Chinese medicine composition preparation method, including
Following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, 80 meshes is crossed and uses 5% by conventional method
Edible glue and 95% medicinal alcohol mixing pelletize again, be pressed into tablet 0.25g/ piece；
(4) dosage adjusts
The content by weight of the chlorogenic acid and Peininine in gained tablet is measured, and adjusts described according to the content
The unit dose of agent makes to contain 3.75mg chlorogenic acid and 0.125mg Peininine in every tablet of tablet.
In another aspect, provide preventing cold of the invention, anti-haze clearing lung-heat Chinese medicine composition preparation method, including
Following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, 80 meshes is crossed and uses 4% by conventional method
Edible glue and the mixing of 95% medicinal alcohol are pelletized again, briquetting, and with+0.1% sweet tea of+1% edible glue of 0.5% carboxymethyl cellulose ethanol
The coating of chrysanthemum glycosides, is made into transparent block agent 15g/ block；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained block agent, and described piece is adjusted according to the content
The unit dose of agent makes to contain 225mg chlorogenic acid and 7.5mg Peininine in every piece of block agent.
In another aspect, provide preventing cold of the invention, anti-haze clearing lung-heat Chinese medicine composition preparation method, including
Following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
It takes 500g Laiyang pear paste that pure water is added to be configured to 800ml to stir evenly, adds fritillary bulb powder 17g, Honegsukle flower P.E 35g mixing equal
Even, heating is boiled, and is cooled to room temperature, and filtering complements to 1000ml with pure water, is loaded in 20ml medicine bottle, tamponade gland, in water-bath
Middle boiling sterilization 10 minutes, is cooled to room temperature, and obtains 30g/ bottles of syrup；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained syrup, and according to content adjustment
The unit dose of syrup makes to contain 450mg chlorogenic acid and 15mg Peininine in every bottle of syrup.
Beneficial effects of the present invention are：
Laiyang pear paste, fritillary bulb powder, Honegsukle flower P.E are mixed, drying, are crushed, system according to theory of traditional Chinese medical science basis by the present invention
It is taken at appropriate dosage forms.Pass through the side's of tearing open experiment, it is determined that the compatibility of these medicinal materials, by adjusting each material rate relationship, so that
Each raw material realizes preferable synergistic function, i.e., after several medicinal material combinations, drug effect is significantly higher than each medicinal material and is used alone
When the sum of effectiveness.In addition, drug effect is more lasting, unexpected effect is generated in terms of preventing cold, anti-haze clearing lung-heat.
The present invention carries out compatibility using above-mentioned raw materials drug, improves clearing lung-heat, eliminating the phlegm effect of fritillary bulb, improves mouth
Sense, pharmacological property is mild, and the crowd of taking is made to be easier to take, suitable for people of all ages, will not damage to human body.
Chinese medicine composition of the invention has no toxic side effect, and is suitble to various people, there is good prevention and health-care effect, meets
Demand of the market to such product.
The present invention is just the drug of integration of drinking and medicinal herbs entirely, and medicine source is abundant, and raw material are easy to get, and compatibility is simple, production method letter
Easy row, use is safe, and dosage is few, low in cost.
It is easy to carry and take simple.Raw material passes through process, and various dosage forms are made, and is suitble to large-scale production, and just
In carrying and taking, meet clinical demand.
Specific embodiment
For a better understanding of the present invention, below with specific example come the technical solution that the present invention will be described in detail, but this
Invention is not limited thereto.
Embodiment 1
The present embodiment provides a kind of preventing colds, the Chinese medicine composition of anti-haze clearing lung-heat, it is the Chinese medicine for including following weight proportion
The granule of raw material：475 parts of Laiyang pear pastes, 15 parts of fritillary bulb powder, 30 parts of Honegsukle flower P.Es and 20 parts of auxiliary materials.
The preparation method of the Chinese medicinal composition granules of the present embodiment is as follows：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and 20 parts of appropriate auxiliary materials, mixed
It is uniformly mixed in conjunction machine, at bulky grain, moisture is dried in drying chamber no more than 0.5%, 80 meshes is crossed, makes by conventional method
Granule 2.5g/ packet is made with 95% medicinal alcohol；
(4) dosage adjusts
Using high performance liquid chromatograph measure gained granule in chlorogenic acid and with HPLC-ELSD method measure Peininine with
The content of poidometer adjusts the unit dose of the granule accordingly, make in every packet granule containing 37.5mg chlorogenic acid and
1.25mg Peininine.
Embodiment 2
The present embodiment provides a kind of preventing colds, the Chinese medicine composition of anti-haze clearing lung-heat, it is the Chinese medicine for including following weight proportion
The tablet of raw material：525 parts of Laiyang pear pastes, 20 parts of fritillary bulb powder, 40 parts of Honegsukle flower P.Es and 30 parts of auxiliary materials.
The preparation method of the Chinese medicine composition tablet of the present embodiment is as follows：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and 25 parts of appropriate auxiliary materials, mixed
It is uniformly mixed in conjunction machine, at bulky grain, moisture is dried in drying chamber no more than 0.5%, cross 80 meshes makes by conventional method
It is pelletized again with 5% edible glue and the mixing of 95% medicinal alcohol, is pressed into tablet 0.25g/ piece.
(4) dosage adjusts
Using high performance liquid chromatograph measure gained granule in chlorogenic acid and with HPLC-ELSD method measure Peininine with
The content of poidometer adjusts the unit dose of the tablet accordingly, make in every tablet of tablet containing 3.75mg chlorogenic acid and
0.125mg Peininine.
Embodiment 3
The present embodiment provides a kind of preventing colds, the Chinese medicine composition of anti-haze clearing lung-heat, it is the Chinese medicine for including following weight proportion
The block agent of raw material：500 parts of Laiyang pear pastes, 17 parts of fritillary bulb powder, 35 parts of Honegsukle flower P.Es and 25 parts of auxiliary materials.
The preparation method of the Chinese medicine composition block agent of the present embodiment is as follows：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and 30 parts of appropriate auxiliary materials, mixed
It is uniformly mixed in conjunction machine, at bulky grain, moisture is dried in drying chamber no more than 0.5%, cross 80 meshes makes by conventional method
With 4% edible glue and 95% medicinal alcohol mixing pelletize again, briquetting, and with+1% edible glue of 0.5% carboxymethyl cellulose ethanol+
The coating of 0.1% stevioside, is made into transparent block agent 15g/ block.
(4) dosage adjusts
Using high performance liquid chromatograph measure gained granule in chlorogenic acid and with HPLC-ELSD method measure Peininine with
The content of poidometer adjusts the unit dose of the block agent accordingly, make in every piece of block agent containing 225mg chlorogenic acid and
7.5mg Peininine.
Embodiment 4
The present embodiment provides a kind of preventing colds, the Chinese medicine composition of anti-haze clearing lung-heat, it is the Chinese medicine for including following weight proportion
The syrup of raw material：500 parts of Laiyang pear pastes, 17 parts of fritillary bulb powder and 35 parts of Honegsukle flower P.Es.
The preparation method of the Chinese medicine composition syrup of the present embodiment is as follows：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
It takes 500g Laiyang pear paste that pure water is added to be configured to 800ml to stir evenly, adds fritillary bulb powder 17g, Honegsukle flower P.E 35g mixing equal
Even, heating is boiled, and is cooled to room temperature, and filtering complements to 1000ml with pure water, is loaded in 20ml medicine bottle, tamponade gland, in water-bath
Middle boiling sterilization 10 minutes, is cooled to room temperature, and obtains 30g/ bottles of syrup.
(4) dosage adjusts
Using high performance liquid chromatograph measure gained granule in chlorogenic acid and with HPLC-ELSD method measure Peininine with
The content of poidometer adjusts the unit dose of the syrup accordingly, make in every bottle of syrup containing 450mg chlorogenic acid and
15mg Peininine.
5 clinical test of embodiment
1. materials and methods
1.1 subjects：In December, 2017, influenza pandemic and haze high-incidence period are chosen frequent in Hospital in Shandong
Outdoor study and with sneezing, rhinorrhea, pharyngeal discomfort, dry cough, have the flu such as phlegm and symptoms of respiratory disease person 80,
Middle masculinity femininity is fifty-fifty, and males focus on 65kg or so, and women weight is in 55kg or so.80 subjects are randomly divided into 8 groups,
Every group of 10 people.
1.2 drug
Chinese medicine composition described in embodiment 1-4 and plain boiled water, according to the Laiyang pear paste of 1 the method for embodiment preparation,
Fritillary bulb powder and Honegsukle flower P.E.
1.3 clinical observation:Above-mentioned 8 kinds of drugs are randomly assigned to 8 groups of subjects, instructions of taking is：Three times a day,
A unit dose every time was continuously taken 3 days, every afternoon 17:00 records the symptom of each subject according to subjects reported
Symptom situation of change is divided into following three kinds by situation：Symptom disappears, symptom improves and without improvement, counts the number of each case,
As the result is shown in the following table 1.
There is the number of certain symptom situation of change daily in 1. clinical observation result of table, i.e., each medicine group.
It can be seen that according to 1 data of table, after taking Chinese medicine composition of the invention, the various symptoms of flu and respiratory disease
It is obvious to disappear, it works compared with single component group significant very fast, has the effect of anti-flu and anti-haze clearing lung-heat well.
The above embodiment of the present invention is only preferred embodiment, is not limited to the scope of the present invention.Ability
The those of ordinary skill in domain can understand spirit of the invention according to above-described embodiment, and make a variety of different modifications and variations.?
Without departing from the spirit of the invention, it is all this etc. modifications and variations it is all within the scope of the present invention.
Claims (8)
1. the Chinese medicine composition of a kind of preventing cold, anti-haze clearing lung-heat, which is characterized in that it is the Chinese medicine for including following weight proportion
The medicament of raw material：
Laiyang pear paste：475-525 parts；
Fritillary bulb powder：15-20 parts；
Honegsukle flower P.E：30-40 parts；
Auxiliary material：20-30 parts.
2. the Chinese medicine composition of preventing cold according to claim 1, anti-haze clearing lung-heat, which is characterized in that the Chinese medicine is former
The weight proportion of material is as follows：
Laiyang pear paste：500 parts；
Fritillary bulb powder：17 parts；
Honegsukle flower P.E：35 parts；
Auxiliary material：25 parts.
3. the Chinese medicine composition of preventing cold according to claim 1 or 2, anti-haze clearing lung-heat, which is characterized in that the medicament
For granule, tablet or block agent.
4. preventing cold according to claim 3, anti-haze clearing lung-heat Chinese medicine composition preparation method, which is characterized in that
Include the following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, crosses 80 meshes, uses 95% by conventional method
The every bagged granules 2.5g/ packet of granule is made in medicinal alcohol；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained granule, and according to content adjustment
The unit dose of granule makes to contain 37.5mg chlorogenic acid and 1.25mg Peininine in every packet granule.
5. preventing cold according to claim 3, anti-haze clearing lung-heat Chinese medicine composition preparation method, which is characterized in that
Include the following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, 80 meshes is crossed and uses 5% by conventional method
Edible glue and 95% medicinal alcohol mixing pelletize again, be pressed into tablet 0.25g/ piece；
(4) dosage adjusts
The content by weight of the chlorogenic acid and Peininine in gained tablet is measured, and adjusts described according to the content
The unit dose of agent makes to contain 3.75mg chlorogenic acid and 0.125mg Peininine in every tablet of tablet.
6. preventing cold according to claim 3, anti-haze clearing lung-heat Chinese medicine composition preparation method, which is characterized in that
Include the following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
According to weight proportion weighing Laiyang pear paste, fritillary bulb powder and Honegsukle flower P.E and appropriate auxiliary material, in mixing machine
In be uniformly mixed, at bulky grain, moisture is dried in drying chamber no more than 0.5%, 80 meshes is crossed and uses 4% by conventional method
Edible glue and the mixing of 95% medicinal alcohol are pelletized again, briquetting, and with+0.1% sweet tea of+1% edible glue of 0.5% carboxymethyl cellulose ethanol
The coating of chrysanthemum glycosides, is made into transparent block agent 15g/ block；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained block agent, and described piece is adjusted according to the content
The unit dose of agent makes to contain 225mg chlorogenic acid and 7.5mg Peininine in every piece of block agent.
7. the Chinese medicine composition of a kind of preventing cold, anti-haze clearing lung-heat, which is characterized in that it is the Chinese medicine for including following weight proportion
The syrup of raw material：
Laiyang pear paste：475-525 parts；
Fritillary bulb powder：15-20 parts；
Honegsukle flower P.E：30-40 parts.
8. preventing cold according to claim 7, anti-haze clearing lung-heat Chinese medicine composition preparation method, which is characterized in that
Include the following steps：
(1) sorting
For Laiyang pear, rotten part of going rotten is discarded,
For fritillary bulb, with selecting genuine main product, selected removal impurity,
For honeysuckle, the secondary product of Shandong main producing region is selected, there must not be impurity mildew；
(2) Raw material processing
Selected Laiyang pear is squeezed the juice using conventional equipment, juice is concentrated in vacuo to d1.2 in 40 DEG C or so, obtains Laiyang pear paste,
Refrigerate it is spare,
Fritillary bulb is quickly rinsed well with normal-temperature water, is dried in drying chamber, 80 meshes are smashed it through, it is standby to obtain fritillary bulb powder
With,
Honeysuckle is extracted 2 hours in multi-function extractor with 40% alcohol reflux, removes the dregs of a decoction, extracting solution is in 40 DEG C or so
It is concentrated in vacuo to d1.2, obtains Honegsukle flower P.E, is refrigerated spare；
(3) preparation
It takes 500g Laiyang pear paste that pure water is added to be configured to 800ml to stir evenly, adds fritillary bulb powder 17g, Honegsukle flower P.E 35g mixing equal
Even, heating is boiled, and is cooled to room temperature, and filtering complements to 1000ml with pure water, is loaded in 20ml medicine bottle, tamponade gland, in water-bath
Middle boiling sterilization 10 minutes, is cooled to room temperature, and obtains described syrup 30g/ bottles；
(4) dosage adjusts
The content by weight of chlorogenic acid and Peininine in measurement gained syrup, and according to content adjustment
The unit dose of syrup makes to contain 450mg chlorogenic acid and 15mg Peininine in every bottle of syrup.
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| CN102166280A (en) * | 2011-04-14 | 2011-08-31 | 陕西省中医药研究院汉唐制药有限公司 | Chinese medicinal composition for preventing and treating common cold and influenza and preparation method thereof |
| CN103355675A (en) * | 2013-07-24 | 2013-10-23 | 广东九天绿药业有限公司 | Composition with lung clearing function and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166280A (en) * | 2011-04-14 | 2011-08-31 | 陕西省中医药研究院汉唐制药有限公司 | Chinese medicinal composition for preventing and treating common cold and influenza and preparation method thereof |
| CN103355675A (en) * | 2013-07-24 | 2013-10-23 | 广东九天绿药业有限公司 | Composition with lung clearing function and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 吴凌: "《食物搭配营养宜忌100分》", 31 August 2016 * |
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