CN102166280A - Chinese medicinal composition for preventing and treating common cold and influenza and preparation method thereof - Google Patents
Chinese medicinal composition for preventing and treating common cold and influenza and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for preventing and treating the common cold and influenza, which consists of the following raw materials: honeysuckle flower, figwort root, mint, tangerine peel, Chinese date and liquoric root in a certain ratio. The Chinese medicinal composition for preventing and treating the common cold and the influenza has an obvious effect and a reasonable formula. Clinical experiments prove that when the Chinese medicinal composition is used for treating various colds, the response of patients is good. The invention also discloses a preparation method for the Chinese medicinal composition, which comprises the following steps of: weighing the raw material components, decocting, filtering, mixing, standing, concentrating and the like. The method is simple in steps, stable in process and easy to implement.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used to prevent and treat common cold and influenza, the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
Common cold is meant coryza, and the influence of human body is only limited to respiratory system usually.All symptoms are all relevant with nose, as nasal mucus, nasal obstruction and sore throat, cough even fever etc.Just can fully recover after general a couple of days.
Influenza is caused by viral infection.Because virus is via air borne, what therefore stand in the breach is nose.Virus at first infects nasal mucosa, and constantly breeding causes nasal inflammation then, diseases such as sneeze, rhinorrhea, nasal obstruction occur.Influenza virus has the infectiousness height, propagates the characteristics such as popular that rapidly, easily take place.
Flu-like symptom: 1, onset is hurried, fear of cold, heating, and body temperature rises in a few hours to 24 hour and reaches the peak, 39 ℃～40 ℃ even higher.Companioned with headache, systemic pain, weak, loss of appetite.Respiratory symptom is lighter, the dry pharynx laryngalgia, and dry cough can have diarrhoea.2, Blushing: the hyperemia of eye conjunctiva outer canthus, pharyngeal congestion has folliculus on the soft palate.Flu-like symptom influences whole body, can cause pneumonia and other complication when serious, can be fatal.The characteristic of influenza virus is that polytype is arranged, and just can occur new viral kind about per ten years.
Modern medicine is divided into influenza: influenza A type and Type B.Clinical typing is: 1, simple type influenza: Acute onset, and 39 ℃～40 ℃ of body temperature, General Symptomies such as companion's fear of cold, weak, headache, muscle joint aches are obvious, and watery nasal discharge, nasal obstruction, dry cough etc. can be arranged.2, pneumonic influenza: more rare, pilosity is born in the crowd of old man, child, original cardiopulmonary disease.3, toxic influenza: with central nervous system and cardiovascular system infringement is feature.Show as hyperpyrexia, blood pressure drops is looked forward, encephalitis meningitis symptom such as convulsions.4, gastrointestinal influenza: rare, be main clinical manifestation with diarrhoea, stomachache, vomiting.
Not not viral this notion, is referred to as " exopathogen invasion " without exception for influenza or flu on the Chinese medicine, no matter because viral cradle is nasal mucosa or respiratory tract, all belong to beyond the internal organs, therefore is called " exopathogen ".Table note of the ancient Chinese and somatic reaction classification by disease roughly divide " anemofrigid cold " and " anemopyretic cold ".
The traditional Chinese medical science is thought and influenza one disease is divided into two kinds of diseases caused by exogenous pathogenic factor and internal injuries.
Diseases caused by exogenous pathogenic factor are the external pathogens of impression, and the visitor closes it and cleans the street in lung meridian, and lung qi must not descend, situations such as its people must snivel, heating, aversion to wind, aversion to cold, headache general pain.Method should be declared and loose.
Internal injury is given birth in the YIN-cold because kidney yang declines, and the kidney ruton is in lung, and the YANG deficiency of cardiopulmonary can not be had body fluid under one's command, and flows clear nasal mucus, and how sleepy patient's nothing be refreshing, or sneeze is endlessly, or bipod is ice-cold, the suitable invigorating YANG of method, and influenza just belongs to the internal injury flu.
Vaccine research and speed of production are slower because virus can only be grown at living cells, the hypotype speed of mutation of influenza virus is fast, make chemicals and influenza virus vaccine be difficult to bring into play its optimal treatment and preventive effect, and, can't effectively predict at present the time and the cycle of flu outbreak again, therefore, anti-influenza virus medicament research is subjected to extensive attention.Chinese medicine have suppress virus replication, stop pathological changes caused by virus, regulate immunologic function, improve pulmonary circulation, comprehensive effect such as antalgic and inflammation relieving, therefore, Chinese medicine has special advantages and vast potential for future development aspect the influenza preventing and treating.
Chinese medicine (also claims SARS (Severe Acute Respiratory Syndrome) in the severe acute respiratory syndrome in 03 year of antagonism, be Severe Acute Respiratory Syndromes, be called for short SARS) and swine flu (influenza A H1N1) aspect in 09 year all play a part very importantly, in the control of influenza, have a clear superiority in.
Summary of the invention
The purpose of this invention is to provide the Chinese medicine composition that is used to prevent and treat common cold and influenza, invasion and attack that both can flu-prevention virus can be killed influenza virus again, and the treatment influenza has positive effect equally when prevention and treatment common cold.
Another object of the present invention provides the preparation method of above-mentioned Chinese medicine composition.
The technical solution adopted in the present invention is, a kind of Chinese medicine composition that is used to prevent and treat common cold and influenza, its raw materials of effective components percentage by weight consists of: Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%.
Another technical scheme of the present invention is that the preparation method of this Chinese medicine composition may further comprise the steps:
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made required preparation according to the conventional formulation method.
One of concrete grammar of step 3 is: the thick paste that obtains in the step 2 is made granule in right amount with sucrose and dextrin, and drying, granulate promptly gets granule.
Two of the concrete grammar of step 3 is: with the direct vacuum drying of the thick paste that obtains in the step 2, pulverize the encapsulated capsule that promptly gets.
Three of the concrete grammar of step 3 is: with a part of thick paste drying and crushing that obtains in the step 2, gained cream powder is granulated with one-step-granulating method with the residue thick paste, and the granule that makes is added an amount of magnesium stearate, mixing, and tabletting, bag film-coat promptly get tablet.
Step 3 can also make the thick paste that obtains in the step 2 preparation of other kinds as required according to the conventional formulation method except that above three kinds of methods.
The beneficial effect that the present invention is used to prevent and treat the Chinese medicine composition of common cold and influenza is: prevention and therapeutic effect are very obvious, reasonable recipe.When the various flu of application of clinic experimentation treatment, unusual good of patient's reaction effect.
The present invention is used to prevent and treat the preparation method of the Chinese medicine composition of common cold and influenza, and step is simple, implements process stabilizing easily.
The specific embodiment
The present invention is described in detail below in conjunction with the specific embodiment.
The present invention is used to prevent and treat the Chinese medicine composition of common cold and influenza, and it is made the raw materials of effective components percentage by weight and consists of:
Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%.
This Chinese medicine composition is granule, capsule, tablet or other conventional formulations.
The present invention should be used to prevent and treat the preparation method of the Chinese medicine composition of common cold and influenza, it is characterized in that, may further comprise the steps:
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made required preparation according to the conventional formulation method.
The usage and dosage of the Chinese medicine composition of the present invention's prevention and treatment common cold and influenza: oral, each dose is equivalent to Chinese medicine composition 10 grams, one day 2 times.
Points for attention: suffer from other serious disease persons and should follow the doctor's advice and take.
Effect and the function of each raw material in the Chinese medicine composition of the present invention's prevention and treatment common cold and influenza cures mainly:
Flos Lonicerae is monarch drug in the side, and it is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Flos Lonicerae has heat-clearing and toxic substances removing, liver heat removing and eyesight improving, removing heat from blood relieves summer heat, and promoting the production of body fluid to quench thirst, diseases prevention are antibiotic, antiviral, Weight-reducing and lipid-lowering, blood pressure lowering, improve effects such as body immunity.Its property sweet cold, gas is fragrant, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance reaches thoroughly and can be eliminating evil.Flos Lonicerae is sweet cold, both clearing heat in QI system, the branch heat that can purify the blood again, and the diffusing merit of slight a surname is arranged again among heat clearing away, thus can control affection due to external wind and heat or epidemic febrile disease from the beginning of the disease that table disease is not separated, interior-heat is contained again.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and as fever of the body, dermexanthesis, send out cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.In " Chongqing hall random notes ", wind-fire is damp and hot in the clear network of Flos Lonicerae, separates the dirty filthy heresy of pestilence.
Radix Scrophulariae and Herba Menthae are ministerial drug in the side.The Radix Scrophulariae cold nature, sweet in the mouth, hardship, salty are returned lung, stomach, kidney channel.Has clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, the effect of detoxicating and resolving stagnation of pathogens.Be used for heat and go into nutrient blood, maculae caused by violent heat pathogen, consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, diphtheria, scrofula, carbuncle sore tumefacting virus.Radix Scrophulariae especially aspect the treatment laryngopharynx swelling and pain effect obvious, the effect that strengthens monarch drug removing summer-heat blood poison is arranged, help monarch drug to alleviate the symptom of pharyngalgia simultaneously.Herba Menthae acrid in the mouth cool in nature, hot to disperse, cool to heat clearing away, clear light cool loosing is dispelling wind and heat pathogens product commonly used.Compendium of Material Medica: Herba Menthae, suffering can be dispersed, and cool profit is clearly specially dispelled the heat in pathogenic wind expelling.So headache, wind syndrome of head, eyes, throat, all diseases of ability to speak, children's's fever (of children) accompanied by fear, and scrofula, skin ulcer scabies are key medicine." Records of Tradition Chinese and Western Medicine in Combination ": the Herba Menthae acrid in the mouth, the clear YUXIANG of gas is scurried, and property is flat.Its power can in saturating muscles and bones, reach the flesh table outward, the logical internal organs of a surname run through meridians, clothes can send out antiperspirant thoroughly cool, be the key medicine that epidemic febrile disease should the cure by diaphoresis person.Herba Menthae has dispelling wind and heat pathogens, the cleaning head, sore-throat relieving, rash, the merit of soothing the liver circulation of qi promoting.Be used for anemopyretic cold, the wind pestilence from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast side of body feeling of distension and oppression.The monarch drug of enhancing dispelling wind-heat is arranged, the effect of rash sore-throat relieving.The two is minister altogether, Herba Menthae separate wind heat from the beginning of pestilent toxicity, the analgesic pestilent toxicity of going into nutrient blood of Radix Scrophulariae is gone out to heal, and reaches relieving exterior-interior syndrome.
Pericarpium Citri Reticulatae and Fructus Jujubae are adjuvant drug in the side.Pericarpium Citri Reticulatae bitter in the mouth, suffering, warm in nature, temperature can circulation of qi promoting, and suffering can be dispersed, and is bitter and sluice.Have regulating qi-flowing for strengthening spleen, the merit of drying dampness to eliminate phlegm is used for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.It is the row QI of the spleen and stomach that Pericarpium Citri Reticulatae mainly acts on.Taste are located in middle Jiao, and middle Jiao's gas is current, and the gas of three warmers is also sprung up thereupon.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, spread all over whole body.The Fructus Jujubae sweet in the mouth, warm in nature.Have invigorating the spleen and replenishing QI, the merit of nourishing blood to tranquillize the mind is used for insufficiency of the spleen lack of appetite, weak loose stool, and the married woman is dirty dry.The cyclic adenosine monophosphate that Fructus Jujubae contained is the essential composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, the control cardiovascular system diseases there is good effect; The Chinese medicine theory thinks that Fructus Jujubae has effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, is patient's good health care nutriments such as weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.Monarch drug and ministerial drug are all cold and cool product, cold and coolly easily injure one's stomach, so select not only can regulate the flow of vital energy QI invigorating but also can relax cold and cool property of Pericarpium Citri Reticulatae and Fructus Jujubae for use, Fructus Jujubae can improve body autoimmunity again, quicken that sb.'s illness took a favorable turn.
Radix Glycyrrhizae is messenger drug in the side, coordinating the actions of various ingredients in a prescription.The Radix Glycyrrhizae sweet in the mouth is flat, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus.
This side's reasonable recipe, the effect of each medicine of distinguishing the flavor of and nature and flavor collocation are rigorous, and be remarkable to the prevention and the therapeutic effect of common cold and influenza.
Pharmacodynamic experiment:
1. resisting pathogenic microbes effect: experiment in vitro shows, various pathogens such as staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. all there is certain inhibitory action, to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus is also effective, and influenza virus, herpesvirus are had inhibitory action.
2. antiinflammatory and refrigeration function: Chinese medicine composition of the present invention is made granule, after being dissolved in water, give rat oral cavity perfusion 5g/kg (granule of 5g/kg), can suppress the rat carrageenan swelling of the feet.Give rat oral cavity perfusion 15g/kg (granule of 15g/kg), can alleviate Ovum Gallus domesticus album swelling of the feet degree.Also have certain refrigeration function, can pass through the stimulating central nervous system system, make skin capillary vascular expansion, promote sweat gland secretion, increase heat radiation, and play the sweating and heat resolving effect.
3. immunosuppressive action: Chinese medicine composition of the present invention is made granule, after being dissolved in water, 5g gives rat oral gavage by every day, logotype 10 days, show and have certain immunosuppressive action, can suppress production of antibodies to atopic diseases, have the effect of the lymphopoiesis of promotion, but human body immunity improving power.
Acute toxicity test:
Select 32 of body weight 180g～240g rat, male and female half and half, be divided into 4 groups at random, first three groups is an experimental group, and the 4th group is the blank group, every group 8, male and female half and half are all behind the fasting 16h (can't help water), morning next day, use Chinese medicine composition of the present invention to extract concentrated solution and irritate stomach twice respectively, intermediate phase was every 8 hours.Wherein, the administration concentration of concentrated solution is in the experiment I group: Chinese medicine composition of the present invention is extracted the gained thick paste be mixed with the solution that 1ml is equivalent to crude drug 1.0g, as the administration concentration of experiment I group.Experiment II group administration concentration: Chinese medicine composition of the present invention is extracted the gained thick paste be mixed with the solution that 1ml is equivalent to crude drug 2.0g, as the administration concentration of experiment II group.Experiment III group administration concentration: Chinese medicine composition of the present invention is extracted the gained thick paste be mixed with the solution that 1ml is equivalent to crude drug 2.6g, as the administration concentration of experiment III group.When trying once that drug level was mixed with drug level greater than experiment III group, as a result medicine too thickness can't normally irritate stomach to rat, illustrative experiment III group has reached the maximum administration concentration that can normally experimentize.Experiment I group, experiment II group and experiment III group are all irritated the stomach medicine of concentration separately by the amount of 20ml/kg.Experiment IV group is the blank group, removes and does not give the experimental drug beyond the region of objective existence, and all the other are identical with 3 groups of test.Give to be subjected to observe immediately behind the reagent thing reaction of animals situation to 6 hour, observe later every day 2 times, observed continuously 14 days, write down the rat response situation day by day.
3 groups of administration as a result and 32 activities in rats of blank group are normal, and administration group stool colour is darker, and soft stool appears in individual animal, and other behavioral activity there is no unusually.After tightly having observed 14 days, animal appearance, behavioral activity, the mental status, appetite (feed consumption), defecation and all no abnormal variation of color, fur and the colour of skin thereof, breathe no abnormality seen, none is dead and poison in all no abnormal secretions in nose, eye, oral cavity, 3 groups of administration and 32 rats of blank group 14 days.The result shows: Chinese medicine composition of the present invention extracts the gained thick paste, is giving three concentration ranks, and maximum volume is irritated the stomach rat twice, and animal does not all have tangible toxic reaction.The medicine total amount that experiment I organizes to rat oral gavage is equivalent to crude drug 40g/kg, is equivalent to 100 times of 50kg Coming-of-Age Day consumption, does not see tangible toxic reaction; The medicine total amount that experiment II organizes to rat oral gavage is equivalent to crude drug 80g/kg, is equivalent to 200 times of 50kg Coming-of-Age Day consumption, does not see tangible toxic reaction; Experiment III is equivalent to crude drug 104g/kg for the medicine total amount of rat oral gavage, is equivalent to 260 times of 50kg Coming-of-Age Day consumption, does not see tangible toxic reaction.So clinical medicine dose of the present invention is perfectly safe.
Case one
High and new technology industrial development zone, Xi'an Zhang, woman, 38 years old.Have some inkling of a cold, cough is had sore throat, has a headache, is felt cold, physical distress, obeys amoxicillin, antiviral granule and GANMAOTONG sheet certainly 3, and symptom is not seen improvement.Taken Chinese medicinal composition granules of the present invention after 3 days, recovery from illness.Its household is infected by it, all takes Chinese medicinal composition granules of the present invention, and only 3 days, the cold symptoms complete obiteration threw off a cold.
Case two
Xi'an enterprise amounts to 126 employees, and the swine flu in 2009 is very popular in the process, all takes Chinese medicinal composition granules of the present invention 3, the whole company no one flu.
Case three
Xi'an Chen, the man, 14 years old, cold, fever, cough, headache, throat pain is shiver all overed with cold, and is sore, 38.5 ℃ of body temperature, and with symptoms such as diarrhoea, vomitings.Took Chinese medicinal composition granules of the present invention 2, body temperature is normal, and headache alleviates, and appetite is normal, is that pharyngeal sense slightly is uncomfortable, and cough continues and obeyed 3, all transference cures, and disease is fully recovered.
Embodiment 1
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 25%, Radix Scrophulariae 15%, Herba Menthae 8%, Pericarpium Citri Reticulatae 10%, Fructus Jujubae 35%, Radix Glycyrrhizae 7%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made granule in right amount with sucrose and dextrin, drying, granulate promptly gets granule.
Embodiment 2
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 25%, Radix Scrophulariae 15%, Herba Menthae 6%, Pericarpium Citri Reticulatae 9%, Fructus Jujubae 38%, Radix Glycyrrhizae 7%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3:, pulverize the encapsulated capsule that promptly gets with the direct vacuum drying of the thick paste that obtains in the step 2.
Embodiment 3
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 23%, Radix Scrophulariae 14%, Herba Menthae 8%, Pericarpium Citri Reticulatae 10%, Fructus Jujubae 36%, Radix Glycyrrhizae 9%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: with a part of thick paste drying and crushing that obtains in the step 2, gained cream powder is granulated with one-step-granulating method with the residue thick paste, and the granule that makes is added an amount of magnesium stearate, mixing, and tabletting, bag film-coat promptly get tablet.
Embodiment 4
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 20%, Radix Scrophulariae 12%, Herba Menthae 7%, Pericarpium Citri Reticulatae 10%, Fructus Jujubae 40%, Radix Glycyrrhizae 11%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made required preparation according to the conventional formulation method.
Embodiment 5
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 21%, Radix Scrophulariae 16%, Herba Menthae 10%, Pericarpium Citri Reticulatae 8%, Fructus Jujubae 37%, Radix Glycyrrhizae 8%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made required preparation according to the conventional formulation method.
Claims (5)
1. a Chinese medicine composition that is used to prevent and treat common cold and influenza is characterized in that, its raw materials of effective components percentage by weight consists of:
Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%.
2. the described preparation method that is used to prevent and treat the Chinese medicine composition of common cold and influenza of a claim 1 is characterized in that, may further comprise the steps:
Step 1: take by weighing following raw material components by weight percentage: Flos Lonicerae 20%～25%, Radix Scrophulariae 12%～16%, Herba Menthae 6%～10%, Pericarpium Citri Reticulatae 8%～10%, Fructus Jujubae 35%～40%, Radix Glycyrrhizae 7%～11%, the percentage by weight summation of above each component is 100%;
Step 2: each raw material components that takes by weighing in the step 1 is mixed, decoct with water twice, the amount of water that decoct the first time is 12 times of raw material gross weight, the amount of water that decoct the second time is 10 times of raw material gross weight, decocts 1.5 hours at every turn, filters, merging filtrate, after leaving standstill 24 hours, the supernatant concentration of getting filtrate becomes temperature in the time of 60 ℃～70 ℃, and relative density is 1.30～1.35 thick paste;
Step 3: the thick paste that obtains in the step 2 is made required preparation according to the conventional formulation method.
3. according to the described preparation method of claim 2, it is characterized in that the concrete grammar of step 3 is: the thick paste that obtains in the step 2 is made granule in right amount with sucrose and dextrin, drying, granulate promptly gets granule.
4. according to the described preparation method of claim 2, it is characterized in that the concrete grammar of step 3 is:, pulverize the encapsulated capsule that promptly gets with the direct vacuum drying of the thick paste that obtains in the step 2.
5. according to the described preparation method of claim 2; it is characterized in that; the concrete grammar of step 3 is: with a part of thick paste drying and crushing that obtains in the step 2; gained cream powder is granulated with one-step-granulating method with the residue thick paste; the granule that makes is added an amount of magnesium stearate; mixing, tabletting, bag film-coat promptly get tablet.
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| CN107821678A (en) * | 2017-12-05 | 2018-03-23 | 神农架林区中医医院 | Detoxification honeysuckle tea and preparation method thereof |
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| CN116077594A (en) * | 2023-01-09 | 2023-05-09 | 陕西省中医药研究院 | Traditional Chinese medicine for treating respiratory tract virus infection |
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Denomination of invention: Chinese medicinal composition for preventing and treating common cold and influenza and preparation method thereof Effective date of registration: 20150819 Granted publication date: 20120321 Pledgee: Bank of Communications Ltd. Shaanxi branch Pledgor: SHAANXI ACADEMY OF TRADITIONAL CHINESE MEDICINE HANTANG PHARMACEUTICAL CO.,LTD. Registration number: 2015610000011 |
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Address after: 710300 No. 18 Caotang 4th Road, Caotang Science and Technology Industrial Base, Xi'an High-tech Zone, Shaanxi Province Patentee after: Shaanxi Hantang Pharmaceutical Co.,Ltd. Address before: 710018 Mingguang Road, Jingkai District, Xi'an City, Shaanxi Province, 39 Patentee before: SHAANXI ACADEMY OF TRADITIONAL CHINESE MEDICINE HANTANG PHARMACEUTICAL CO.,LTD. |
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