CN108853254A - A kind of Chinese medicine composition of promoting blood circulation and breaking stagnation and its preparation method and application - Google Patents
A kind of Chinese medicine composition of promoting blood circulation and breaking stagnation and its preparation method and application Download PDFInfo
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- CN108853254A CN108853254A CN201810735278.1A CN201810735278A CN108853254A CN 108853254 A CN108853254 A CN 108853254A CN 201810735278 A CN201810735278 A CN 201810735278A CN 108853254 A CN108853254 A CN 108853254A
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Abstract
The invention discloses Chinese medicine composition of a kind of promoting blood circulation and breaking stagnation and its preparation method and application, solving the problem of that existing curative effect of medication is relatively simple cannot fundamentally adjust each internal organs of benefit to be allowed to tend to coordinate, and belong to technical field of traditional Chinese medicine.The Chinese medicine composition of promoting blood circulation and breaking stagnation of the invention, by the following raw material through over cleaning, system of scalding, drying, processing, ingredient and etc. be made：Prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel.Preparation method of the invention, technique is fine, and step is simple to operation, avoids using organic solvent, safe and non-toxic, whole quality controllable, meets GMP requirement, the Chinese medicine composition for the promoting blood circulation and breaking stagnation being prepared, and has a promoting blood circulation and breaking stagnation, promoting menstruation disappear ruffian the effect of.It can be used in hemostasis stopping, abdominal mass, scaly dry skin, a symptom of blood stasis, orbit is dim black, and hectic fever is thin thin, the treatment medication of amenorrhea patient.
Description
Technical field
The present invention relates to the technical field of Chinese medicine composition more particularly to the Chinese medicine compositions and its system of a kind of promoting blood circulation and breaking stagnation
Preparation Method and application.
Background technique
Traditional Chinese Medicine thinks that under normal physiological conditions, blood is run in arteries and veins, once passages through which vital energy circulates receives damage, so that broken
It splits, causes blood excessive, then form syndrome of blood stasis, so-called blood circulating out of vessels is hemostasis；On the other hand, blood under normal circumstances, is given birth to
Reason state is such as water its " popular more than ", if blood can generate " solidifying then arteries and veins is obstructed ", " arteries and veins not general rule because pathological factor influences
Blood does not flow " situations such as, thus " inside becoming blood stasis "." stasis of blood ",《Say text》It explains：" hematocele." the existing area of both blood stasis and hemostasis
It is not related not again, it is not smooth that blood stasis refers to that (1) blood is slow in action；(2) dead blood is jammed blood vessels；(3) blood vessels founder is different；(4) blood
Liquid is from four kinds of pathological states such as stop over products.Hemostasis, which refers to, condenses not all right blood, is the pathological product of blood stasis.After hemostasis is existing again
It will affect the normal operation of blood, and can lead to and aggravate the pathological state of blood stasis, the two reciprocal causation.
Chinese medicine thinks that blood stasis is due to kidney deficiency and liver, deficiency of qi and blood, and blood vessels lose logical caused.Be divided into actual situation, empty person mostly because
Insufficiency of vital energy and blood and kidney deficiency, real person is mostly by the cold solidifying, stagnation of the circulation of vital energy and blood stasis.In treatment, because insufficiency of vital energy and blood then answers tonifying Qi and blood；Then because of kidney deficiency
It needs first under help；Because it is cold solidifying then need it is warming channel and expelling cold；Because the stagnation of the circulation of vital energy then needs dispersing stagnated hepatoqi；Because blood stasis then needs activating microcirculation and removing stasis medicinal.
Woman's amenorrhoea Chinese medicine is also known as " menostasis ", " the not moon ", " amenorrhea ".For this disease, Chinese medicine is early on the books, such as《It is interior
Through plain same》It says：" disease of two sun make up one's mind spleen, there is inability of coition, morbid amenorrhea ", is added：" troubled thoughts pent-up ", " vessels of the uterus closes, and the motive is not
Must descend to lead to ", " liver blood loss " etc., illustrate the understanding for having had deeper degree to the etiology and pathogenesis of amenorrhoea at that time.Eastern Han Dynasty's Zhang Zhongjing
《Synopsis Golden Chamber the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and is controlled》While inheriting, the cause of disease of amenorrhoea is concluded：" because empty, product is cold, knot
Gas is broken off for Zhu Jingshui ", and be unfolded to be discussed in detail, it enriches《Interior warp》Related theory.Song Dynasty Chen Ziming《It is good that married woman is infused in school
Side》The etiology and pathogenesis of this disease is described specifically, and proposes the treatment method for the treatment of obstruction with tonics：" married woman month water is obstructed, or
Satisfy because liquor-saturated into room, or labour is excessive due to wound, or because of haematemesis blood loss, hurt liver and spleen, but grows its source, through certainly logical ".Nowadays, people couple
The understanding of this disease is fairly perfect, has void to have reality in the cause of disease, has benefit to have in treatment logical, and common drug for invigorating blood circulation and eliminating stasis presses drug effect
Feature is different, can be divided into blood rearing movable blood medicine, such as Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, radix paeoniae rubra；Blood circulation and stasis-eliminating medicine, such as Rhizoma Chuanxiong, safflower, cattail pollen；It dispels
Stasis of blood anodyne, such as olibanum, myrrh, rhizoma corydalis；Blood-breaking dissipating bind medicine, such as trigone, curcuma zedoary, peach kernel.And these curative effect of medication ratios
It is more single, it cannot fundamentally adjust each internal organs such as bushing, liver,kidney,spleen to be allowed to tend to coordinate, Conception Vessel and Governor Vessel tends to be gentle, yin-yang
It is attributed to balance.
Summary of the invention
The present invention in view of the above technical problems, provides Chinese medicine composition of a kind of promoting blood circulation and breaking stagnation and preparation method thereof and answers
With can fundamentally adjust and mend each internal organs and tend to coordinate, Conception Vessel and Governor Vessel tends to be gentle, and yin-yang is made to be attributed to balance.
To achieve the goals above, the present invention provides the following technical solutions：
A kind of Chinese medicine composition of promoting blood circulation and breaking stagnation, it is made of the raw material of following parts by weight：86~92 parts of prepared RADIX ET RHIZOMA RHEI, soil
6~10 parts of soft-shelled turtle worm, 16~20 parts of leech, 11~15 parts of safflower, 11~15 parts of radix bupleuri, 6~10 parts of dried lacquer, 33~37 parts of peach kernel,
33~37 parts of caulis clematidis armandii, 16~20 parts of radix scutellariae, 88~95 parts of glutinous rehmannia, 35~40 parts of Radix Paeoniae Alba and 25~30 parts of green peel.
Further, the Chinese medicine composition of the promoting blood circulation and breaking stagnation, it is made of the raw material of following parts by weight：Prepared RADIX ET RHIZOMA RHEI
86~92 parts, 6~10 parts of ground bettle, 16~20 parts of leech, 11~15 parts of safflower, 11~15 parts of radix bupleuri, 6~10 parts of dried lacquer, peach
33~37 parts of benevolence, 33~37 parts of caulis clematidis armandii, 16~20 parts of radix scutellariae, 88~95 parts of glutinous rehmannia, 35~40 parts of Radix Paeoniae Alba and green peel 25~30
Part.
Further, the Chinese medicine composition of the promoting blood circulation and breaking stagnation, it is made of following steps：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and
The non-medicinal effects of green peel remove, spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure 0.3
~0.5mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove
Remove kind of a skin；
(4) dry
Peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets are taken to be respectively placed at 60~80 DEG C of temperature dry 20
~30min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5~6:1, at steam pressure 0.1-0.2Mpa,
It steams to inside and outside and is taken out in black, be placed at 60~80 DEG C of temperature dry 20~30min, it is spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4~5；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take the prepared RADIX ET RHIZOMA RHEIs of the parts by weight, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel,
Peach kernel and caulis clematidis armandii carry out ingredient, and 60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；
(7) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15~20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
Further, the Chinese medicine composition of the promoting blood circulation and breaking stagnation is prepared into pharmaceutically acceptable dosage form.
Further, the dosage form is capsule.
And a kind of preparation method of the Chinese medicine composition of above-mentioned promoting blood circulation and breaking stagnation is provided, include the following steps：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and
The non-medicinal effects of green peel remove, spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure 0.3
~0.5mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove
Remove kind of a skin；
(4) dry
Peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets are taken to be respectively placed at 60~80 DEG C of temperature dry 20
~30min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5~6:1, at steam pressure 0.1-0.2Mpa,
It steams to inside and outside and is taken out in black, be placed at 60~80 DEG C of temperature dry 20~30min, it is spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4~5；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take the prepared RADIX ET RHIZOMA RHEIs of the parts by weight, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel,
Peach kernel and caulis clematidis armandii carry out ingredient, and 60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；
(7) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15~20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
Further, the preparation method of the Chinese medicine composition of the promoting blood circulation and breaking stagnation, includes the following steps：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and
The non-medicinal effects of green peel remove, spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure is
0.4mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove
Remove kind of a skin；
(4) dry
Peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets are taken to be respectively placed under temperature 70 C dry 25min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5:1, at steam pressure 0.2Mpa, steam to interior
Outside it is in black, takes out, is placed under temperature 70 C dry 25min, it is spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take the prepared RADIX ET RHIZOMA RHEIs of the parts by weight, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel,
Peach kernel and caulis clematidis armandii carry out ingredient, and 70 DEG C heating, drying 25 minutes, cool after sterilizing；
(7) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
And the Chinese medicine composition of above-mentioned promoting blood circulation and breaking stagnation a kind of is provided and is preparing the application in promoting blood circulation and breaking stagnation drug.Using
Method is that the Chinese medicine composition of the promoting blood circulation and breaking stagnation is made to granule or capsule, and granule takes orally twice, every time daily
The Chinese medicine composition of 1.6g invigorating kidney, promoting blood circulation；Capsule takes orally twice daily, 4 tablets each time, every capsule invigorating kidney, promoting blood circulation containing 0.4g
Chinese medicine composition.In addition, the Chinese medicine composition of invigorating kidney, promoting blood circulation also can be applicable to dosage form described in any pharmacy, such as ball
Agent, powder, tablet, capsule, granule, syrup, oral solution etc..
Compared with prior art, beneficial effects of the present invention are：
The Chinese medicine composition of promoting blood circulation and breaking stagnation of the invention supplies kidney qi and liver blood using several kinds of Chinese medicinal materials, and punching, which is appointed, to be filled,
Be able to metaplasia menses, have promoting blood circulation and breaking stagnation, promoting menstruation disappear ruffian the effect of.It is reasonable to be formulated selected drug matching, mutually there is collaboration to make
With can heighten the effect of a treatment.Prove that there is safety and validity, can be used in hemostasis stopping, abdominal mass by zoopery,
Scaly dry skin, a symptom of blood stasis, orbit is dim black, and hectic fever is thin thin, the treatment medication of amenorrhea patient.
The preparation method of the Chinese medicine composition of promoting blood circulation and breaking stagnation of the invention, technique is fine, and step is simple to operation, avoids making
It is safe and non-toxic with organic solvent, it is whole quality controllable, meet GMP and requires, the Chinese medicine composition for the promoting blood circulation and breaking stagnation being prepared,
It can be used in hemostasis stopping, abdominal mass, scaly dry skin, a symptom of blood stasis, orbit is dim black, and hectic fever is thin thin, the treatment medication of amenorrhea patient.
Specific embodiment
The present invention provides a kind of Chinese medicine composition of promoting blood circulation and breaking stagnation, it is made of the raw material of following parts by weight：Prepared RADIX ET RHIZOMA RHEI
86~92 parts, 6~10 parts of ground bettle, 16~20 parts of leech, 11~15 parts of safflower, 11~15 parts of radix bupleuri, 6~10 parts of dried lacquer, peach
Benevolence part and 33~37 parts, 33~37 parts of caulis clematidis armandii, 16~20 parts of radix scutellariae, 88~95 parts of glutinous rehmannia, Radix Paeoniae Alba 35~40, green peel 25~30
Part.
And a kind of preparation method of the Chinese medicine composition of above-mentioned promoting blood circulation and breaking stagnation is provided, include the following steps：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and
The non-medicinal effects of green peel remove, spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure 0.3
~0.5mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove
Remove kind of a skin；
(4) dry
It takes peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peeling caulis clematidis armandii and rhubarb tablets to be respectively placed at 60~80 DEG C of temperature to do
Dry 20~30min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5~6:1, at steam pressure 0.1-0.2Mpa,
It steams to inside and outside and is taken out in black, be placed at 60~80 DEG C of temperature dry 20~30min, it is spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4~5；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Skin caulis clematidis armandii is removed, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take the prepared RADIX ET RHIZOMA RHEIs of the parts by weight, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel,
Peach kernel and caulis clematidis armandii carry out ingredient, and 60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；
(7) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15~20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
The raw material pharmacological action used in the present invention is as follows：
Rheum officinale：
【Nature and flavor and channel tropism】Hardship is trembled with fear.Returns spleen, stomach, large intestine, liver, pericardium channel.
【Function with cure mainly】Heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It is stagnant for real heat
Constipation, blood-head tells nosebleed, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery,
Jaundice and reddish urine, stranguria, oedema；Externally treating burns and scalds.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system, is used for hot eyes pharynx swelling, gingivitis.It is ripe
Rheum officinale rush down exert oneself to delay, purging fire for removing toxin, be used for pathogenic fire,toxin and furuncles.The hemostasis of charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis, has stasis of blood haemorrhage for blood-head.
Ground bettle：
【Nature and flavor and channel tropism】It is salty, it trembles with fear；It is slightly poisonous.Return liver warp.
【Function with cure mainly】Dissipating blood stasis with potent drugs, reunion of fractured tendons and bones.For traumatic injury, injury of tendon and muscle fracture, blood stasis, postpartum stasis
Abdominal pain , abdominal mass and lump.
Leech：
【Nature and flavor and channel tropism】It is salty, bitter, it puts down；It is slightly poisonous.Return liver warp.
【Function with cure mainly】Blood-breaking promoting menstruation, Zhu Yu Xiao Disorder.For blood stasis , abdominal mass and lump, hemiplegia falls and flutters damage
Wound.
Safflower：
【Nature and flavor and channel tropism】It is acrid in flavour and warm in nature.Converge to heart and liver channels.
【Function with cure mainly】Blood circulation, removing blood stasis and acesodyne.For menostasis, dysmenorrhea, lochia , abdominal mass and lump, the thoracic obstruction heart
Bitterly, stasis of blood, chest side of body twinge, injury from falling down, sore swell and ache curative.
Radix bupleuri：
【Nature and flavor and channel tropism】It is pungent, bitter, it is slightly cold.Return liver, gallbladder, lung channel.【Function with cure mainly】Evacuation is brought down a fever, soothing liver-qi stagnation, is risen
Lift yang-energy.For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, rectal prolapse.
Dried lacquer：
【Nature and flavor and channel tropism】It is acrid in flavour and warm in nature；It is toxic.Return liver, the spleen channel.
【Function with cure mainly】Broken stasis of blood promoting menstruation, disperse accumulation desinsection.For blood stasis closed , lumps in the chest and abdomen, abdominal pain due to enterositosis.
Peach kernel：
【Nature and flavor and channel tropism】Bitter, sweet, flat.Return heart, liver, large intestine channel.
【Function with cure mainly】Promoting blood circulation, relax bowel and defecation is relieving cough and asthma.For amenorrhea and algomenorrhea , abdominal mass and lump, pulmonary abscess intestines
Carbuncle, injury from falling down, dry constipation of intestines, cough and asthma.
Caulis clematidis armandii：
【Nature and flavor and channel tropism】Hardship is trembled with fear.Return heart, small intestine, bladder meridian.
【Function with cure mainly】Inducing diuresis for treating strangurtia, relieving restlessness and restlessness are newborn under promoting menstruation.For stranguria, oedema, vexed urine is red, and dispute is raw
Sore, menostasis cream is few, damp and hot numbness pain.
Radix scutellariae：
【Nature and flavor and channel tropism】Hardship is trembled with fear.Return lung, gallbladder, spleen, large intestine, small intestinl channel.
【Function with cure mainly】Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention.For damp-warm syndrome, summer-heat and damp, chest tightness and emesis, damp and hot ruffian
It is full, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, threatened abortion.
Glutinous rehmannia：
【Nature and flavor and channel tropism】It is sweet, it trembles with fear.Return heart, liver and kidney channel.
【Function with cure mainly】Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.Enter ying blood, febrile virulent maculae, hematemesis and epistaxis, pyreticosis wound for heat
Yin, the deep red polydipsia of tongue, Tianjin hinder constipation, fever due to yin deficiency, hectic fever due to yin labor heat, Heat Diabetes.
Radix Paeoniae Alba：
【Nature and flavor and channel tropism】Bitter, acid, it is slightly cold.Return liver, the spleen channel.
【Function with cure mainly】Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, menstruation is not
It adjusts, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, headache and dizziness.
Green peel：
【Nature and flavor and channel tropism】It is bitter, acrid in flavour and warm in nature.Return liver, gallbladder, stomach meridian.
【Function with cure mainly】Soothing the liver relieving stagnant Qi, disperse accumulationization are stagnant.For distending pain in the chest and hypochondrium, hernia pain, breast illness, acute mastitis, dyspepsia gas
It is stagnant, abdominal distention.
In order to make those skilled in the art more fully understand technical solution of the present invention, below in conjunction with embodiment to this
Invention is further detailed.
It is prepared by the Chinese medicine composition of 1 promoting blood circulation and breaking stagnation of embodiment
(1) it cleans
Rheum officinale is placed in and is cleaned on platform, rheum officinale medicinal part is dry root and rhizome, and it is non-to remove radicula, crust and silt etc.
Medicinal part, it is spare；
Ground bettle is placed in and is cleaned on platform, ground bettle medicinal part is female adult hirudo leech, removes impurity, foreign matter etc., spare；
Leech is placed in and is cleaned on platform, leech medicinal part is dry entirety, removes impurity, foreign matter etc., spare；
Safflower is placed in and is cleaned on platform, safflower medicinal part is dry all, dis-medicinal parts such as removing impurity, foreign matter,
It is spare；
Radix bupleuri is placed in and is cleaned on platform, radix bupleuri medicinal part is dry entirety, removes impurity, foreign matter etc., spare；
Dried lacquer is placed in and is cleaned on platform, dried lacquer medicinal part is the dry product after resin is processed, removes impurity, foreign matter
Deng spare；
Peach kernel is placed in and is cleaned on platform, peach kernel medicinal part is dry mature seed, and it is non-to remove impurity, foreign matter, nucleocapsid etc.
Medicinal part, it is spare；
Caulis clematidis armandii is placed in and is cleaned on platform, caulis clematidis armandii medicinal part is dry rattan, and it is non-to remove impurity, foreign matter, rough bark etc.
Medicinal part, it is spare；
Radix scutellariae is placed in and is cleaned on platform, radix scutellariae medicinal part is dry root, and it is non-to remove silt, foreign matter, fibrous root and rough bark etc.
Medicinal part, it is spare；
Glutinous rehmannia is placed in and is cleaned on platform, glutinous rehmannia medicinal part is root tuber, removes the non-medicines such as silt, foreign matter, reed head and fibrous root
It is spare with position；
Radix Paeoniae Alba is placed in and is cleaned on platform, Radix Paeoniae Alba medicinal part is dry root, removes silt, foreign matter, removes end to end and radicula
And the dis-medicinal parts such as crust, it is spare；
Green peel is placed in and is cleaned on platform, green peel medicinal part is the pericarp of dry young fruit or immature fruit, remove silt,
The dis-medicinal parts such as foreign matter, it is spare.
(2) it cleans
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are respectively placed in tumbling-box type medicine-washing machine, drunk with flowing
Water is cleaned, and wash clarification of water, hydraulic pressure 0.3mpa are washed till.
(3) cutting
Rheum officinale, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are set and are respectively placed in medicine cutter, 2-4mm piece is cut into.
(4) system of scalding
The water wait 3 times of material amounts processed of scalding is added into tilting-type reaction pot, boils, takes in rheum officinale investment boiling water, stirs, scald
It is put into cold water to being pulled out when unfolding, easily rubbing with the hands and go by shrinkage to kind of skin, removes kind of a skin.
(5) dry
It takes peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets to be respectively placed in heated-air circulation oven to be done
It is dry, 60 DEG C of drying temperature, drying time 30min.
(6) it processes
Rhubarb tablets are taken to set in medicine processing device, every 100Kg rheum officinale adds yellow rice wine 20Kg, mixes thoroughly, steam pressure 0.1Mpa, steams to inside and outside
It is in black；It takes out, sets in heated-air circulation oven and be dried, 60 DEG C of drying temperature dry 30min；
Net ground bettle is taken to set in cylinder type medicine roasting machine, stir-fry is deepened to compared with primary colors, when appearing ground bettle intrinsic smell, takes out,
It cools；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4；
Safflower and radix bupleuri is taken to be respectively placed in cylinder type medicine roasting machine, stir-bake to yellowish, taking-up cools, spare；
It takes dried lacquer to be broken into fritter, sets in cylinder type medicine roasting machine, be calcined to shrivelled black smoke and use up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is set in cylinder type medicine roasting machine, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare.
(7) ingredient
Take 86 parts of prepared RADIX ET RHIZOMA RHEI, 6 parts of ground bettle, 6 parts of leech, 15 parts of safflower, 11 parts of radix bupleuri, 6 parts of dried lacquer, 16 parts of radix scutellariae,
Yellow 88 parts, 35 parts of Radix Paeoniae Alba, 25 parts of green peel, 33 parts of peach kernel, 37 parts of caulis clematidis armandii, carry out ingredient, are dried after sterilizing with 60 DEG C of heating of interlayer
It is dry, it drying time 30 minutes, cools.
(8) it crushes
Take sterilizing after prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach kernel,
Caulis clematidis armandii is ground into fine powder with crushing unit, is ground into 100 mesh fine powders, crushes yield >=94%.
(9) fine powder mixes
The 12 taste fine powders such as step (8) prepared RADIX ET RHIZOMA RHEI are set in three-dimensional motion mixer, mixes 15 minutes, obtains promoting blood circulation and breaking stagnation
Chinese medicine composition.
It is prepared by the Chinese medicine composition of 2 promoting blood circulation and breaking stagnation of embodiment
Step (1)~(4), step (8) with embodiment 1, the difference is that,
The hydraulic pressure of step (2) is 0.4mpa；
The drying temperature of step (5) is 70 DEG C, drying time 25min；
Step (6) processes
Rhubarb tablets are taken to set in medicine processing device, every 100Kg rheum officinale adds yellow rice wine 20Kg, mixes thoroughly, steam pressure 0.2Mpa, steams to inside and outside
It is in black；It takes out, sets in heated-air circulation oven and be dried, 70 DEG C of drying temperature dry 25min；
Net ground bettle is taken to set in cylinder type medicine roasting machine, stir-fry is deepened to compared with primary colors, when appearing ground bettle intrinsic smell, takes out,
It cools；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 10:4；
Safflower and radix bupleuri is taken to be respectively placed in cylinder type medicine roasting machine, stir-bake to yellowish, taking-up cools, spare；
It takes dried lacquer to be broken into fritter, sets in cylinder type medicine roasting machine, be calcined to shrivelled black smoke and use up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is set in cylinder type medicine roasting machine, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare.
(7) ingredient
Take 89 parts of prepared RADIX ET RHIZOMA RHEI, 8 parts of ground bettle, 18 parts of leech, 13 parts of safflower, 12 parts of radix bupleuri, 9 parts of dried lacquer, 18 parts of radix scutellariae,
Yellow 92 parts, 36 parts of Radix Paeoniae Alba, 27 parts of green peel, 35 parts of peach kernel, 34 parts of caulis clematidis armandii, carry out ingredient, are dried after sterilizing with 70 DEG C of heating of interlayer
It is dry, it drying time 25 minutes, cools.
(9) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 18 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
It is prepared by the Chinese medicine composition of 3 promoting blood circulation and breaking stagnation of embodiment
Step (1)~(4), step (8) with embodiment 1, the difference is that,
The hydraulic pressure of step (2) is 0.5mpa；
The drying temperature of step (5) is 80 DEG C, drying time 20min；
Step (6) processes
Rhubarb tablets are taken to set in medicine processing device, every 120Kg rheum officinale adds yellow rice wine 20Kg, mixes thoroughly, steam pressure 0.2Mpa, steams to inside and outside
It is in black；It takes out, sets in heated-air circulation oven and be dried, 80 DEG C of drying temperature dry 20min；
Net ground bettle is taken to set in cylinder type medicine roasting machine, stir-fry is deepened to compared with primary colors, when appearing ground bettle intrinsic smell, takes out,
It cools；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, in yellowish-brown
It is taken out when color, weeds out talcum powder, cooled, it is spare；Leech and amount of talc ratio are 2:1；
Safflower and radix bupleuri is taken to be respectively placed in cylinder type medicine roasting machine, stir-bake to yellowish, taking-up cools, spare；
It takes dried lacquer to be broken into fritter, sets in cylinder type medicine roasting machine, be calcined to shrivelled black smoke and use up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is set in cylinder type medicine roasting machine, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare.
(7) ingredient
Take 92 parts of prepared RADIX ET RHIZOMA RHEI, 10 parts of ground bettle, 20 parts of leech, 11 parts of safflower, 15 parts of radix bupleuri, 10 parts of dried lacquer, 20 parts of radix scutellariae,
95 parts of glutinous rehmannia, 40 parts of Radix Paeoniae Alba, 30 parts of green peel, 37 parts of peach kernel, 33 parts of caulis clematidis armandii carry out ingredient, with 80 DEG C of interlayer heating after sterilizing
Drying, drying time 20 minutes, cools.
(9) prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach after taking sterilizing
Renhe caulis clematidis armandii is ground into 100 mesh fine powders, mixes 20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
The granule preparation of the Chinese medicine composition of 4 promoting blood circulation and breaking stagnation of embodiment
The Chinese medicine composition of promoting blood circulation and breaking stagnation prepared by embodiment 2 is set in trough type mixing machine, it is suitable that boiled purified water is added
Amount mixes 15 minutes, softwood is made；The softwood made is placed in oscillating granulator and crosses the pelleting of 16 mesh screens；Particle is filled
It in stainless steel barrel, sets in spray-drying pelleting machine and is dried, control inlet air temperature：85 DEG C, 85 DEG C of temperature of charge, dry 3.5
Hour, water content≤6% takes out；Whole grain is carried out by 18 mesh screens are crossed in the particle merging oscillating granulator after drying, is lived
The granule of the Chinese medicine composition of blood broken stasis of blood.
The capsule preparation of the Chinese medicine composition of 5 promoting blood circulation and breaking stagnation of embodiment
The granule that embodiment 4 obtains is filled with fully-automatic capsule filling machine, controls operating frequency, filling speed 800-
1000/minute, every dress particle 0.4g of gelatin hollow capsule, content uniformity are controlled in ± 7.5% range of 0.4g, are lived
The capsule of the Chinese medicine composition of blood broken stasis of blood.
1 safety testing of experimental example
Test method：The healthy kunming mice for taking 18~22g of weight is divided into 4 groups, and every group 5, half male and half female is right respectively
The mouse of group 1~3 takes the Chinese medicinal composition granules of the promoting blood circulation and breaking stagnation of the preparation of embodiment 4, and group 4 is blank control.Group 1~3
At 24 hours medicine for oral administration 3 times, each 120g/kg, 30 times of people's dosage are equivalent to, observe mouse survival situation.
Test result：The present invention is all survived through acute toxicity test, mouse, it was demonstrated that its good security.
2 safety testing of experimental example
Test method：The healthy white rat for taking 200~240g of weight is divided into 4 groups, and every group 8, half male and half female is right respectively
The mouse of group 1~3 takes the Chinese medicinal composition granules of the removing blood stasis and hemostasis of the preparation of embodiment 4, and group 4 is blank control.Group 1~3
Successive administration 6 months, 1 daily administration 80g/kg is organized, organizes 2 daily administration 40g/kg, organizes 3 daily administration 20g/kg, observes mouse
Survival.
Test result：The present invention is through long term toxicity test, large dosage of 80g/kg (20 times that are equivalent to people's dosage)；Middle dosage
40g/kg (be equivalent to people with dosage 10 times)；Low dose of 20g/kg (5 times that are equivalent to people's dosage) successive administration 6 months, greatly
There was no significant difference compared with the control group for part index number；Histopathological examination result has no significantly related with test medicine
Pathological change.
3 efficiency assay of experimental example
Test method：Female patient 26 for being diagnosed as breast illness disease are collected, average age 42 years old, clinical symptoms were spargosis
It is full, lump has been touched with hand, agglomeration distending pain is joined in charitable and pious deeds anger growth and decline, and face is intensely dark, bitter taste, and pale tongue with thin fur is white etc..Give 26
Capsule prepared by patient's embodiment 5,2 times oral daily, 4 tablets each time, 20 days as a treatment course of successive administration are administered altogether 3
A course for the treatment of, observation clinical symptoms eliminate situation.
Index of assessment of curative effect：
It cures：Original clinical symptoms disappear, no lump, no distending pain；
Alleviate：Original clinical symptom relief, lump become smaller, and distending pain mitigates；
In vain：Original clinical symptoms are without improvement.
Total effective rate=(curing patient's number of cases+reduction of patient number of cases)/total patient's number of cases × 100%
Experimental result：After 3 courses for the treatment of, 26 patients cure 20, improve 4, invalid 2, total effective rate reaches
92.3%.
4 efficiency assay of experimental example
Test method：Collect amenorrhoea, Hypomenorrhea, menses have clot, women 24 of bellyache in menstrual period, average age 40
Year the capsule of the preparation of embodiment 5 is given, 2 times oral daily, 4 tablets each time, 10 days as a treatment course of successive administration are given altogether
2 courses for the treatment of of medicine, observation clinical symptoms eliminate situation.
Index of assessment of curative effect：
It cures：Hyper-menorrhea, menses are without clot, menstrual period without abdominal pain；
Alleviate：Hyper-menorrhea, menses clot become smaller, bellyache in menstrual period mitigates；
In vain：Original symptom is without improvement.
Total effective rate=(curing patient's number of cases+reduction of patient number of cases)/total patient's number of cases × 100%
Experimental result：After 2 courses for the treatment of, 24 patients cure 19, improve 4, invalid 1, total effective rate reaches
95.8%.
It is above that certain exemplary embodiments of the invention are only described by way of explanation, undoubtedly, for ability
The those of ordinary skill in domain without departing from the spirit and scope of the present invention can be with a variety of different modes to institute
The embodiment of description is modified.Therefore, foregoing description is regarded as illustrative in nature, and should not be construed as wanting right of the present invention
Ask the limitation of protection scope.
Claims (8)
1. a kind of Chinese medicine composition of promoting blood circulation and breaking stagnation, which is characterized in that it is made of the raw material of following parts by weight：Prepared RADIX ET RHIZOMA RHEI 86
~92 parts, 6~10 parts of ground bettle, 16~20 parts of leech, 11~15 parts of safflower, 11~15 parts of radix bupleuri, 6~10 parts of dried lacquer, peach kernel
33~37 parts, 33~37 parts of caulis clematidis armandii, 16~20 parts of radix scutellariae, 88~95 parts of glutinous rehmannia, 35~40 parts of Radix Paeoniae Alba and 25~30 parts of green peel.
2. the Chinese medicine composition of promoting blood circulation and breaking stagnation according to claim 1, which is characterized in that it is by the original of following parts by weight
Material is made：89 parts of prepared RADIX ET RHIZOMA RHEI, 8 parts of ground bettle, 18 parts of leech, 13 parts of safflower, 12 parts of radix bupleuri, 9 parts of dried lacquer, 35 parts of peach kernel, river wood
34 parts logical, 18 parts of radix scutellariae, 92 parts of glutinous rehmannia, 36 parts of Radix Paeoniae Alba and 27 parts of green peel.
3. the Chinese medicine composition of promoting blood circulation and breaking stagnation according to claim 1 or 2, which is characterized in that it is by following steps system
At：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel
Non- medicinal effects remove, it is spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure be 0.3~
0.5mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove kind
Skin；
(4) dry
Take peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets be respectively placed at 60~80 DEG C of temperature dry 20~
30min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5~6:1, at steam pressure 0.1-0.2Mpa, steam extremely
Inside and outside is in black, is taken out, and dry 20~30min is placed at 60~80 DEG C of temperature, spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, when being in yellowish-brown
It takes out, weeds out talcum powder, cool, it is spare；Leech and amount of talc ratio are 10:4~5；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, the peach kernel of the parts by weight
And caulis clematidis armandii, ingredient is carried out, 60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；
(7) take sterilizing after prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach kernel and
Caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15~20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
4. the Chinese medicine composition of described in any item promoting blood circulation and breaking stagnations according to claim 1~3, which is characterized in that be prepared into
Pharmaceutically acceptable dosage form.
5. the Chinese medicine composition of the promoting blood circulation and breaking stagnation according to claim 4, which is characterized in that the dosage form is capsule
Agent.
6. the preparation method of the Chinese medicine composition of promoting blood circulation and breaking stagnation according to claim 1 or 2, which is characterized in that including such as
Lower step：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel
Non- medicinal effects remove, it is spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure be 0.3~
0.5mpa is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove kind
Skin；
(4) dry
Take peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets be respectively placed at 60~80 DEG C of temperature dry 20~
30min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5~6:1, at steam pressure 0.1-0.2Mpa, steam extremely
Inside and outside is in black, is taken out, and dry 20~30min is placed at 60~80 DEG C of temperature, spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, when being in yellowish-brown
It takes out, weeds out talcum powder, cool, it is spare；Leech and amount of talc ratio are 10:4~5；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, the peach kernel of the parts by weight
And caulis clematidis armandii, ingredient is carried out, 60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；
(7) take sterilizing after prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach kernel and
Caulis clematidis armandii is ground into 100 mesh fine powders, mixes 15~20 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
7. the preparation method of the Chinese medicine composition of promoting blood circulation and breaking stagnation according to claim 6, which is characterized in that including walking as follows
Suddenly：
(1) it cleans
Respectively by prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, peach kernel, caulis clematidis armandii, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel
Non- medicinal effects remove, it is spare；
(2) cutting is cleaned
Rheum officinale after cleaning, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba and green peel are cleaned with flowing drinking water respectively, hydraulic pressure 0.4mpa,
It is washed till wash clarification of water, cuts into 2-4mm piece；
(3) system of scalding
It takes in rheum officinale investment boiling water, stirs, scald to kind of skin by shrinkage to being pulled out when unfolding, easily rubbing with the hands and go, be put into cold water, remove kind
Skin；
(4) dry
Peach kernel, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, caulis clematidis armandii and rhubarb tablets are taken to be respectively placed under temperature 70 C dry 25min；
(5) it processes
It takes rheum officinale that yellow rice wine is added to mix thoroughly, the weight ratio of rheum officinale and yellow rice wine is 5:1, at steam pressure 0.2Mpa, steam to inside and outside equal
It in black, takes out, is placed under temperature 70 C dry 25min, it is spare；
It takes net ground bettle to fry to compared with primary colors to deepen, when appearing ground bettle intrinsic smell, takes out, cool；
It takes talcum powder to set in cylinder type medicine roasting machine, when being heated to flexible state, puts into leech, scald to micro- and heave, when being in yellowish-brown
It takes out, weeds out talcum powder, cool, it is spare；Leech and amount of talc ratio are 10:4；
It takes safflower and radix bupleuri to distinguish stir-bake to yellowish, takes out, cool, it is spare；
It takes dried lacquer to be broken into fritter, is calcined to shrivelled black smoke and uses up, take out, cool, it is spare；
Caulis clematidis armandii is taken, is fried to yellow, slightly focal spot, aromatic, taking-up cools, spare；
(6) ingredient
Take prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, the peach kernel of the parts by weight
And caulis clematidis armandii, ingredient is carried out, 70 DEG C heating, drying 25 minutes, cool after sterilizing；
(7) take sterilizing after prepared RADIX ET RHIZOMA RHEI, ground bettle, leech, safflower, radix bupleuri, dried lacquer, radix scutellariae, glutinous rehmannia, Radix Paeoniae Alba, green peel, peach kernel and
Caulis clematidis armandii is ground into 100 mesh fine powders, mixes 18 minutes, obtains the Chinese medicine composition of promoting blood circulation and breaking stagnation.
8. the Chinese medicine composition of described in any item promoting blood circulation and breaking stagnations is in preparing promoting blood circulation and breaking stagnation drug according to claim 1~3
Using.
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| CN101274035A (en) * | 2007-03-27 | 2008-10-01 | 北京亚东生物制药有限公司 | Compositions for promoting blood circulation, menstruation and eliminating mass, preparation and quality control method |
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| CN101274035A (en) * | 2007-03-27 | 2008-10-01 | 北京亚东生物制药有限公司 | Compositions for promoting blood circulation, menstruation and eliminating mass, preparation and quality control method |
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