CN103830635A - Traditional Chinese medicine preparation for treating irregular menstruation and amenorrhea - Google Patents
Traditional Chinese medicine preparation for treating irregular menstruation and amenorrhea Download PDFInfo
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- CN103830635A CN103830635A CN201410073004.2A CN201410073004A CN103830635A CN 103830635 A CN103830635 A CN 103830635A CN 201410073004 A CN201410073004 A CN 201410073004A CN 103830635 A CN103830635 A CN 103830635A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating irregular menstruation and amenorrhea. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicines: leonurus, fructus evodiae, codonopsis pilosula, rhizoma sparganii, angelica sinensis, rhizoma cyperi, salviae miltiorrhizae, flowers carthami, radix rehmanniae preparata, rhizoma atractylodis macrocephalae, trogopterus dung, radix dipsaci, pericarpium citri reticulatae, pericarpium citri reticulatae viride, peach kernels, myrrh, radix bupleurim, cortex moutan, hematoxylon, cortex lycii radicis, ligusticum wallichii, roots of common peony, puerarin, radix ophiopogonis, scutellaria baicalensis, eucommia ulmoides, corydalis tuber, cinnamon, rhizoma atractylodis, scorpio, leeches, centipede, coptis chinensis, mangnolia officinalis, frankincense, akebiaquinata, elecampane, Chinese-dates and liquorice which are decocted, filtered, concentrated and dried to prepare granules. The preparation has a good curative effect to irregular menstruation, dysmenorrhea and amenorrhea of women, and is strong in universality and easy to popularize and apply.
Description
Technical field
The present invention discloses a kind of Chinese medicine preparation for the treatment of menoxenia, amenorrhea, belongs to field of medicaments.
Background technology
Menoxenia also claims menoxenia, common gynecological disease.Show as the abnormal of menstrual cycle or amount of bleeding, or stomachache and General Symptoms when month premenstrual, menstrual period.Amenorrhea is symptom common in gynaecopathia, can be caused by various reason.Conventionally amenorrhea is divided into two kinds of constitutional and Secondary cases.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (except gestation or age of sucking), menstruation apolipsis exceedes 6 months persons and is called secondary amenorrhea.Dysmenorrhea can be divided into again two kinds of primary dysmenorrhea and secondary dysmenorrheas, primary dysmenorrhea has dysmenorrhea to rise all to occur pain repeatedly later at every turn while referring to from menarche, secondary dysmenorrhea refers to menophania and starts to have a stage before and after menstrual onset, not feel pain, progressively there is stomachache later, and aggravation gradually.
The disease in menstrual period such as menoxenia, dysmenorrhea, amenorrhea, cause of disease complexity, disease stubbornness, easily recurrence, uses the means poor effect of doctor trained in Western medicine at present.The traditional Chinese medical science is by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, utilize that Chinese crude drug is dredged, nourishing, tonification, often there is good curative effect, the present inventor is according to self experience of practising medicine for many years, on the basis of traditional good recipe, again compatibility obtains a new Chinese prescription, and the menoxenia to women, dysmenorrhea, amenorrhea all have curative effect well; And utilize modern pharmaceutical technology, and make Chinese medicine granules, universality is strong, is easy to apply.Its effect has obtained clinical trial checking.
Summary of the invention
The object of the invention is to develop a kind of Chinese medicine preparation, make it all have good therapeutic effect to menoxenia, dysmenorrhea, amenorrhea etc., and said preparation will conveniently take, universality is strong.
In view of above object inventor is according to self clinical experience for many years, the advantage of comprehensive traditional proved recipe, compatibility medical material again, obtains a new Chinese prescription, and utilizes modern pharmaceutical technology to make Chinese medicine preparation, and said preparation is to menoxenia, dysmenorrhea, amenorrhea, the disease in menstrual period such as disorder of menstrual cycle all has therapeutic effect well, and has obtained the checking of clinical trial, and the Chinese prescription of Chinese medicine preparation of the present invention is: Herba Leonuri 28-33 weight portion, Fructus Evodiae 23-27 weight portion, Radix Codonopsis 17-32 weight portion, Rhizoma Sparganii 17-23 weight portion, Radix Angelicae Sinensis 12-18 weight portion, Rhizoma Cyperi 13-18 weight portion, Radix Salviae Miltiorrhizae 12-17 weight portion, Flos Carthami 18-23 weight portion, Radix Rehmanniae Preparata 21-25 weight portion, Rhizoma Atractylodis Macrocephalae 13-17 weight portion, Oletum Trogopterori 13-17 weight portion, Radix Dipsaci 15-20 weight portion, Pericarpium Citri Reticulatae 11-16 weight portion, Pericarpium Citri Reticulatae Viride 10-15 weight portion, Semen Persicae 10-15 weight portion, Myrrha 10-16 weight portion, Radix Bupleuri 11-15 weight portion, Cortex Moutan 12-17 weight portion, Lignum Sappan 9-12 weight portion, Cortex Lycii 9-12 weight portion, Rhizoma Chuanxiong 12-16 weight portion, Radix Paeoniae Rubra 12-16 weight portion, Radix Puerariae 11-15 weight portion, Radix Ophiopogonis 9-12 weight portion, Radix Scutellariae 9-12 weight portion, Cortex Eucommiae 9-12 weight portion, Rhizoma Corydalis 12-17 weight portion, Cortex Cinnamomi 10-14 weight portion, Rhizoma Atractylodis 11-16 weight portion, Scorpio 6-8 weight portion, Hirudo 5-7 weight portion, Scolopendra 2-4 weight portion, Rhizoma Coptidis 6-8 weight portion, Cortex Magnoliae Officinalis 8-12 weight portion, Olibanum 8-10 weight portion, Caulis Akebiae 8-10 weight portion, Radix Aucklandiae 7-9 weight portion, Fructus Jujubae 17-24 weight portion, Radix Glycyrrhizae 17-24 weight portion.
Optimum prescription 1 is: Herba Leonuri 30 weight portions, Fructus Evodiae 25 weight portions, Radix Codonopsis 20 weight portions, Rhizoma Sparganii 20 weight portions, Radix Angelicae Sinensis 15 weight portions, Rhizoma Cyperi 16 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Carthami 20 weight portions, Radix Rehmanniae Preparata 24 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions, Oletum Trogopterori 15 weight portions, Radix Dipsaci 17 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Semen Persicae 12 weight portions, Myrrha 12 weight portions, Radix Bupleuri 13 weight portions, Cortex Moutan 14 weight portions, Lignum Sappan 11 weight portions, Cortex Lycii 11 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Paeoniae Rubra 15 weight portions, Radix Puerariae 13 weight portions, Radix Ophiopogonis 11 weight portion, Radix Scutellariae 11 weight portions, the Cortex Eucommiae 11 weight portions, Rhizoma Corydalis 15 weight portions, Cortex Cinnamomi 12 weight portions, Rhizoma Atractylodis 13 weight portions, Scorpio 7 weight portions, Hirudo 6 weight portions, Scolopendra 3 weight portions, Rhizoma Coptidis 7 weight portions, Cortex Magnoliae Officinalis 10 weight portions, Olibanum 9 weight portions, Caulis Akebiae 9 weight portions, the Radix Aucklandiae 8 weight portions, Fructus Jujubae 20 weight portions, Radix Glycyrrhizae 20 weight portions.
Optimum prescription 2 is: Herba Leonuri 32 weight portions, Fructus Evodiae 26 weight portions, Radix Codonopsis 18 weight portions, Rhizoma Sparganii 18 weight portions, Radix Angelicae Sinensis 16 weight portions, Rhizoma Cyperi 15 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Flos Carthami 22 weight portions, Radix Rehmanniae Preparata 21 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions, Oletum Trogopterori 14 weight portions, Radix Dipsaci 16 weight portions, Pericarpium Citri Reticulatae 14 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Semen Persicae 12 weight portions, Myrrha 14 weight portions, Radix Bupleuri 12 weight portions, Cortex Moutan 14 weight portions, Lignum Sappan 11 weight portions, Cortex Lycii 11 weight portions, Rhizoma Chuanxiong 15 weight portions, Radix Paeoniae Rubra 15 weight portions, Radix Puerariae 13 weight portions, Radix Ophiopogonis 11 weight portion, Radix Scutellariae 11 weight portions, the Cortex Eucommiae 11 weight portions, Rhizoma Corydalis 14 weight portions, Cortex Cinnamomi 13 weight portions, Rhizoma Atractylodis 13 weight portions, Scorpio 7 weight portions, Hirudo 7 weight portions, Scolopendra 4 weight portions, Rhizoma Coptidis 7 weight portions, Cortex Magnoliae Officinalis 11 weight portions, Olibanum 9 weight portions, Caulis Akebiae 9 weight portions, the Radix Aucklandiae 8 weight portions, Fructus Jujubae 22 weight portions, Radix Glycyrrhizae 22 weight portions.
The preparation technology of Chinese medicine preparation of the present invention is:
1) accurately take according to described Chinese prescription above: Herba Leonuri, Fructus Evodiae, Radix Codonopsis, Rhizoma Sparganii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Oletum Trogopterori, Radix Dipsaci, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Myrrha, Radix Bupleuri, Cortex Moutan, Lignum Sappan, Cortex Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Puerariae, Radix Ophiopogonis, Radix Scutellariae, the Cortex Eucommiae, Rhizoma Corydalis, Cortex Cinnamomi, Rhizoma Atractylodis, Scorpio, Hirudo, Scolopendra, Rhizoma Coptidis, Cortex Magnoliae Officinalis, Olibanum, Caulis Akebiae, the Radix Aucklandiae, Fructus Jujubae, Radix Glycyrrhizae, pulverize respectively, mix;
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Medicine of the present invention, uses warm boiled water.
The raw material of Chinese prescription of the present invention is:
Herba Leonuri: acrid in the mouth; Bitter; Property micro-enter.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, water disappears.Control menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
Fructus Evodiae: warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.
Radix Codonopsis: property is sweet is flat.Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Rhizoma Sparganii: acrid in the mouth; Puckery; Cool.Enter liver.Spleen channel.Control lump in the abdomen, gather, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, postnatal blood stasis stomachache, traumatic injury.
Radix Angelicae Sinensis: sweet in the mouth; Pungent; Bitter; Warm in nature.Return liver; The heart; Spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Cure mainly all cards of blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Rhizoma Cyperi: sweet in the mouth, be slightly cold, nontoxic.Enter liver, tri-jiao channel.The resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, colic of cold type stomachache, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.For menoxenia due to blood stasis, dysmenorrhea, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal.
Flos Carthami: the special fragrance of tool, mildly bitter flavor.Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, can treat traumatic injury.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes swollen effect.
Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.The yin nourishing of enriching blood, life essence-filling, marrow-benefitting.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth; Sweet; Warm in nature.Return spleen; Stomach warp.Invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dampness diuretic; Reduce phlegm, hidroschesis; Antiabortive; Increase appetite.
Oletum Trogopterori: sweet, temperature.Promoting blood circulation to remove blood stasis, parch to black hemostasis.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis.
Radix Dipsaci: tonifying liver, bone and muscle strengthening, determines meridians, only through in (muscles and bones) ache, antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, the stillborn fetus that falls, the cough-relieving hemoptysis of coughing, controls red white turbid urine.
Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Pericarpium Citri Reticulatae Viride: bitter in the mouth is pungent, warm in nature.Enter liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization are stagnant.For costa sternales gastral cavity distending pain, acute mastitis, colic, stagnation of QI due to dyspepsia.
Semen Persicae: bitter in the mouth, property are sweet is flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Myrrha: bitter in the mouth, pungent, property is flat.Enter liver, spleen, the heart, kidney channel.Loose blood detumescence, analgesic therapy granulation promoting.Take for a long time relaxing muscles and tendons film, promoting blood circulation, teeth consolidating tooth, long beard and hair.
Radix Bupleuri: cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Rheumatism pyretic arthralgia.
Lignum Sappan: sweet, salty, flat.GUIXIN, liver, spleen channel.Promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.
Cortex Lycii: cold in nature, sweet in the mouth.Removing heat from blood is except steaming, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Cure mainly headache; Menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; Ulcer sores.
Radix Paeoniae Rubra: bitter in the mouth, property is flat, nontoxic.Have scattered silt, invigorate blood circulation, the effect of pain relieving, removing fire from the liver, cure mainly the diseases such as menoxenia, the stagnant stomachache of expectorant, arthralgia, chest pain, costalgia.
Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.
The Cortex Eucommiae: Gan Weixin, temperature.There is invigorating the liver and kidney, strong waist knee joint, bone and muscle strengthening, antiabortive effect.
Rhizoma Corydalis: bitter in the mouth, pungent, warm in nature; Return liver, the heart, stomach warp; Benefaction is wandered away, and can rise to fall to have promoting blood circulation to remove blood stasis, effect of promoting the circulation of QI to relieve pain.
Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet.Return kidney, spleen, the heart, Liver Channel.Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Cure mainly: the wet tired transporting imbalance causing of taste, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthritis.
Scorpio: acrid in the mouth, property is flat; Poisonous.Return Liver Channel.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Hirudo: salty in the mouth hardship, property is flat, poisonous.Enter liver, urinary bladder channel.Cure mainly the diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.
Scolopendra: acrid in the mouth, slightly warm in nature, slightly poisonous, enter Liver Channel.Relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion, open stasis of blood removing toxic substances, Shu Li joint, external treatment meridians apoplexy, facial hemiparalysis, numb hand and foot.
Rhizoma Coptidis: bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.
Cortex Magnoliae Officinalis: bitter in the mouth; Pungent; Warm in nature.Return through spleen channel; Stomach warp; Large intestine channel.Circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Cure mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; Fullness in the chest is breathed with cough.
Olibanum: arduous, temperature.Enter the heart, liver, spleen channel.Regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Caulis Akebiae: hardship; Cold in nature.Enter heart channel, small intestine meridian, urinary bladder channel.Clearing away heart-fire, diuresis, the stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, sore throat pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.
The Radix Aucklandiae: acrid in the mouth; Bitter; Warm in nature.Return spleen; Large intestine, tri-jiao channel.Circulation of qi promoting, pain relieving, spleen invigorating, helps digestion.Cure mainly promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For heavy after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.
Fructus Jujubae: sweet in the mouth, slightly warm in nature.Energy invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; Blood deficiency fistula Huang, become thin, or women is dirty dry, spirit is uneasy.
Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic.Cure mainly vital organs of the human body cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw pathogenic fire purging heat, the ripe use exterior cold of fall apart of use, goes pharyngalgia, removes pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.
Compared with prior art, Chinese medicine preparation of the present invention has following distinguishing feature and technological progress:
1, compared with prior art, Chinese medicine preparation of the present invention all has good therapeutic effect to menoxenia, dysmenorrhea, amenorrhea etc., and cure rate is high, is difficult for recurrence.
2, Chinese medicine preparation of the present invention, universality is strong, facilitates patient to use, and is easy to apply.
The specific embodiment
Embodiment 1:
1) accurately take according to described Chinese prescription above: Herba Leonuri 280g, Fructus Evodiae 230g, Radix Codonopsis 170g, Rhizoma Sparganii 170g, Radix Angelicae Sinensis 120g, Rhizoma Cyperi 130g, Radix Salviae Miltiorrhizae 120g, Flos Carthami 180g, Radix Rehmanniae Preparata 210g, Rhizoma Atractylodis Macrocephalae 130g, Oletum Trogopterori 130g, Radix Dipsaci 150g, Pericarpium Citri Reticulatae 110g, Pericarpium Citri Reticulatae Viride 100g, Semen Persicae 100g, Myrrha 100g, Radix Bupleuri 110g, Cortex Moutan 120g, Lignum Sappan 90g, Cortex Lycii 90g, Rhizoma Chuanxiong 120g, Radix Paeoniae Rubra 120g, Radix Puerariae 110g, Radix Ophiopogonis 90g, Radix Scutellariae 90g, Cortex Eucommiae 90g, Rhizoma Corydalis 120g, Cortex Cinnamomi 100g, Rhizoma Atractylodis 110g, Scorpio 60g, Hirudo 50g, Scolopendra 20g, Rhizoma Coptidis 60g, Cortex Magnoliae Officinalis 80g, Olibanum 80g, Caulis Akebiae 80g, Radix Aucklandiae 70g, Fructus Jujubae 170g, Radix Glycyrrhizae 170g, pulverize respectively, mix,
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Embodiment 2:
1) accurately take according to described Chinese prescription above: Herba Leonuri 330g, Fructus Evodiae 270g, Radix Codonopsis 320g, Rhizoma Sparganii 230g, Radix Angelicae Sinensis 180g, Rhizoma Cyperi 180g, Radix Salviae Miltiorrhizae 170g, Flos Carthami 230g, Radix Rehmanniae Preparata 250g, Rhizoma Atractylodis Macrocephalae 170g, Oletum Trogopterori 170g, Radix Dipsaci 200g, Pericarpium Citri Reticulatae 160g, Pericarpium Citri Reticulatae Viride 150g, Semen Persicae 150g, Myrrha 160g, Radix Bupleuri 150g, Cortex Moutan 170g, Lignum Sappan 120g, Cortex Lycii 120g, Rhizoma Chuanxiong 160g, Radix Paeoniae Rubra 160g, Radix Puerariae 150g, Radix Ophiopogonis 120g, Radix Scutellariae 120g, Cortex Eucommiae 120g, Rhizoma Corydalis 170g, Cortex Cinnamomi 140g, Rhizoma Atractylodis 160g, Scorpio 80g, Hirudo 70g, Scolopendra 40g, Rhizoma Coptidis 80g, Cortex Magnoliae Officinalis 120g, Olibanum 100g, Caulis Akebiae 100g, Radix Aucklandiae 90g, Fructus Jujubae 240g, Radix Glycyrrhizae 240g, pulverize respectively, mix,
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Embodiment 3:
1) accurately take according to described Chinese prescription above: Herba Leonuri 300g, Fructus Evodiae 250g, Radix Codonopsis 200g, Rhizoma Sparganii 200g, Radix Angelicae Sinensis 150g, Rhizoma Cyperi 160g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 200g, Radix Rehmanniae Preparata 240g, Rhizoma Atractylodis Macrocephalae 150g, Oletum Trogopterori 150g, Radix Dipsaci 170g, Pericarpium Citri Reticulatae 140g, Pericarpium Citri Reticulatae Viride 120g, Semen Persicae 120g, Myrrha 120g, Radix Bupleuri 130g, Cortex Moutan 140g, Lignum Sappan 110g, Cortex Lycii 110g, Rhizoma Chuanxiong 150g, Radix Paeoniae Rubra 150g, Radix Puerariae 130g, Radix Ophiopogonis 110g, Radix Scutellariae 110g, Cortex Eucommiae 110g, Rhizoma Corydalis 150g, Cortex Cinnamomi 120g, Rhizoma Atractylodis 130g, Scorpio 70g, Hirudo 60g, Scolopendra 30g, Rhizoma Coptidis 70g, Cortex Magnoliae Officinalis 100g, Olibanum 90g, Caulis Akebiae 90g, Radix Aucklandiae 80g, Fructus Jujubae 200g, Radix Glycyrrhizae 200g, pulverize respectively, mix,
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Embodiment 4:
1) accurately take according to described Chinese prescription above: Herba Leonuri 300g, Fructus Evodiae 250g, Radix Codonopsis 200g, Rhizoma Sparganii 200g, Radix Angelicae Sinensis 150g, Rhizoma Cyperi 160g, Radix Salviae Miltiorrhizae 150g, Flos Carthami 200g, Radix Rehmanniae Preparata 240g, Rhizoma Atractylodis Macrocephalae 150g, Oletum Trogopterori 150g, Radix Dipsaci 170g, Pericarpium Citri Reticulatae 140g, Pericarpium Citri Reticulatae Viride 120g, Semen Persicae 120g, Myrrha 120g, Radix Bupleuri 130g, Cortex Moutan 140g, Lignum Sappan 110g, Cortex Lycii 110g, Rhizoma Chuanxiong 150g, Radix Paeoniae Rubra 150g, Radix Puerariae 130g, Radix Ophiopogonis 110g, Radix Scutellariae 110g, Cortex Eucommiae 110g, Rhizoma Corydalis 150g, Cortex Cinnamomi 120g, Rhizoma Atractylodis 130g, Scorpio 70g, Hirudo 60g, Scolopendra 30g, Rhizoma Coptidis 70g, Cortex Magnoliae Officinalis 100g, Olibanum 90g, Caulis Akebiae 90g, Radix Aucklandiae 80g, Fructus Jujubae 200g, Radix Glycyrrhizae 200g, pulverize respectively, mix,
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Embodiment 5:
1) accurately take according to described Chinese prescription above: Herba Leonuri 290g, Fructus Evodiae 240g, Radix Codonopsis 310g, Rhizoma Sparganii 220g, Radix Angelicae Sinensis 160g, Rhizoma Cyperi 150g, Radix Salviae Miltiorrhizae 160g, Flos Carthami 190g, Radix Rehmanniae Preparata 220g, Rhizoma Atractylodis Macrocephalae 140g, Oletum Trogopterori 160g, Radix Dipsaci 170g, Pericarpium Citri Reticulatae 150g, Pericarpium Citri Reticulatae Viride 120g, Semen Persicae 140g, Myrrha 130g, Radix Bupleuri 140g, Cortex Moutan 160g, Lignum Sappan 100g, Cortex Lycii 100g, Rhizoma Chuanxiong 130g, Radix Paeoniae Rubra 150g, Radix Puerariae 120g, Radix Ophiopogonis 110g, Radix Scutellariae 100g, Cortex Eucommiae 100g, Rhizoma Corydalis 130g, Cortex Cinnamomi 130g, Rhizoma Atractylodis 150g, Scorpio 60g, Hirudo 50g, Scolopendra 40g, Rhizoma Coptidis 60g, Cortex Magnoliae Officinalis 110g, Olibanum 100g, Caulis Akebiae 80g, Radix Aucklandiae 70g, Fructus Jujubae 230g, Radix Glycyrrhizae 180g, pulverize respectively, mix,
2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
3) in Chinese medicine water extracting liquid, add starch, sucrose granulation, be finished product.
Embodiment 6: the clinical trial of Chinese prescription of the present invention
Clinical trial is divided into two parts, and Part I is acute and chronic toxicity test, and Part II is clinical effectiveness experiment.
(1), animal acute toxicity and chronic toxicity experiment:
Preliminary experiment shows, Chinese medicinal granule of the present invention, and toxicity is very little, cannot measure LD
50, therefore, according to maximum amount feeding.
1, animal acute toxicity test
Medicine: embodiment of the present invention 1-5 gained Chinese medicinal granule.
Experimental animal: regular grade NIH mice, body weight 20g ± 2g, male and female half and half.
Method and result:
1), by 5 kinds of each 50g of Chinese medicinal granule, be modulated into solution by 150ml warm water respectively.
2), experiment mice is divided into 5 groups of male and female half and half at random, 5 kinds of By Chinese Medicines of feeding respectively, volume 2ml/10g body weight, close observation 8h also notes down, and continues to observe 7 days;
3), in 7 days, mice is without death, behavior is active, food ration is as usual, hair color light, without loose dirty, is had a liking for saliva without fainting from fear, eye, mouth, nose, ear and crissum be without abnormal secretions, the nothing rotten toe that docks.From 5 groups, select respectively 25 execution (5 every group), finding of naked eye: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes, and shows that two kinds of these Chinese medicinal granules are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: embodiment of the present invention 1-5 gained Chinese medicinal granule.
Animal: regular grade SD rat, body weight 210g ± 10g, male and female half and half.
Method and result:
1), the configuration of 5 kinds of Chinese medicinal granules: be divided into high, medium and low three dosage groups, be respectively 120,60,30 times of edible for patients amount, be mixed into solution with warm water 1:1 respectively;
2), experimental mouse is divided into 5 groups at random, the solution that feeding modulates continuously respectively, feeding 180 days continuously, observe animal general toxic reaction and the order of severity, after execution, check each position by rule of operation, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach;
3), through long-term feeding, all there is not toxic reaction in 5 groups of rats.Physically well develop.Naked eyes outward appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN and matched group relatively change without pathologic.All not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, 5 kinds of Chinese medicinal granules show without chronic toxicity animal.
By above two toxicity tests, prove that the Chinese medicinal granule that the present invention makes by embodiment 1-5 is safe, have no side effect, can be taken by patient.
(2) clinical effectiveness experiment:
The therapeutic effect of Chinese medicine preparation of the present invention to menoxenia, dysmenorrhea, amenorrhea:
1), case selection
100 routine patients are divided into A, B, C, D, five groups of E at random.Case situation is in table 1.
The each group of table 1 case situation catalog
| Group | Female | Age | Mean age |
| A group | 20 | 16-37 | 29.5 |
| B group | 20 | 17-35 | 27.2 |
| C group | 20 | 18-36 | 30.8 |
| D group | 20 | 17-37 | 28.4 |
| E group | 20 | 18-34 | 28.9 |
2), accept foundation for medical treatment
Through hospital diagnosis, according to National Diagnostic Criteria, 100 routine female patients all suffer from menoxenia, dysmenorrhea, amenorrhea etc., all can be used as the standard of selecting case.
3), Therapeutic Method
A, B, C, D, five groups of E are taken respectively embodiment 1-5 gained Chinese medicine preparation, 15g/ time, every day three times, 5 hours, interval.All patient treatment time is 30 days.
4), criterion of therapeutical effect
Take symptom and sign situation as clinical appraisal index.
(1), cure: menstruation recovers normally completely, can keep rule after cutting drug withdrawal, when menstrual onset without severe pain sense.
(2), effectively: symptom is improved in varying degrees or takes a turn for the better, need to continue medication treatment.
(3), invalid: symptom is without any improvement or take a turn for the better, and even has the trend of development.
5), interpretation of result:
Apply Chinese medicine preparation of the present invention, viewing test case 100 examples, the results are shown in Table 2.
Table 2 result of the test
Interpretation of result: as shown in table 2, these five groups to the total effective rate of menoxenia, dysmenorrhea, amenorrhea all more than 85%, the total effective rate that wherein C group and D organize corresponding two optimum prescriptions reaches 100%, cure rate also reaches more than 70%.This explanation, Chinese medicinal granule of the present invention has and cures very significantly and therapeutic effect menoxenia, dysmenorrhea, amenorrhea, compared with prior art has very significant advantage.
Claims (5)
1. treat a Chinese medicine preparation for menoxenia, amenorrhea, it is characterized in that the Chinese prescription of described Chinese medicine preparation is:
2. a kind of Chinese medicine preparation for the treatment of menoxenia, amenorrhea as claimed in claim 1, is characterized in that the Chinese prescription of described Chinese medicine preparation is:
3. a kind of Chinese medicine preparation for the treatment of menoxenia, amenorrhea as claimed in claim 1, is characterized in that the Chinese prescription of described Chinese medicine preparation is:
4. a kind of Chinese medicine preparation for the treatment of menoxenia, amenorrhea as described in as arbitrary in claim 1-3, is characterized in that the preparation method of described Chinese medicine preparation is forgiven following steps:
Step 1) takes: Herba Leonuri, Fructus Evodiae, Radix Codonopsis, Rhizoma Sparganii, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Oletum Trogopterori, Radix Dipsaci, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Semen Persicae, Myrrha, Radix Bupleuri, Cortex Moutan, Lignum Sappan, Cortex Lycii, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Puerariae, Radix Ophiopogonis, Radix Scutellariae, the Cortex Eucommiae, Rhizoma Corydalis, Cortex Cinnamomi, Rhizoma Atractylodis, Scorpio, Hirudo, Scolopendra, Rhizoma Coptidis, Cortex Magnoliae Officinalis, Olibanum, Caulis Akebiae, the Radix Aucklandiae, Fructus Jujubae, Radix Glycyrrhizae, pulverize respectively, mix;
Step 2) add the purified water of 6 times of weight, reflux and decoct 2 hours, a filters to get filtrate; In filtering residue, add the purified water of 4 times of weight, then the decoction 2 hours that refluxes, b filters to get filtrate; Filtrate a and b are mixed, carry out concentrating under reduced pressure, cumulative volume is reduced to original 1/4, be Chinese medicine water extracting liquid, for subsequent use;
Step 3) adds starch, sucrose granulation in Chinese medicine water extracting liquid, is finished product.
5. a kind of Chinese medicine preparation for the treatment of menoxenia, amenorrhea as described in as arbitrary in claim 1-3, is characterized in that described Chinese medicine preparation is used for the treatment of menoxenia, dysmenorrhea, amenorrhea.
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| CN104398994A (en) * | 2014-12-08 | 2015-03-11 | 成都锦汇科技有限公司 | Gelatin health product |
| CN104873927A (en) * | 2015-05-12 | 2015-09-02 | 杭州美誉医药有限公司 | Traditional Chinese medicine preparation for treating irregular menstruation, as well as preparation method and application thereof |
| CN105079327A (en) * | 2015-09-25 | 2015-11-25 | 汤华淑 | Traditional Chinese medicine composition for treating amenorrhea |
| CN105797051A (en) * | 2016-05-27 | 2016-07-27 | 秦红星 | Traditional Chinese medicinal composition for treating amenorrhea caused by blood stagnation |
| CN105816786A (en) * | 2016-05-27 | 2016-08-03 | 秦红星 | Traditional Chinese medicine pills for treating blood stagnation menstrual block and preparing method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401919A (en) * | 2008-09-09 | 2009-04-08 | 孙立华 | Traditional Chinese medicine for preventing and controlling menorrhalgia |
| CN101757354A (en) * | 2008-12-11 | 2010-06-30 | 董根荣 | Medicament composition for treating dysmenorrhea and preparation method thereof |
-
2014
- 2014-02-28 CN CN201410073004.2A patent/CN103830635B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401919A (en) * | 2008-09-09 | 2009-04-08 | 孙立华 | Traditional Chinese medicine for preventing and controlling menorrhalgia |
| CN101757354A (en) * | 2008-12-11 | 2010-06-30 | 董根荣 | Medicament composition for treating dysmenorrhea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104398994A (en) * | 2014-12-08 | 2015-03-11 | 成都锦汇科技有限公司 | Gelatin health product |
| CN104873927A (en) * | 2015-05-12 | 2015-09-02 | 杭州美誉医药有限公司 | Traditional Chinese medicine preparation for treating irregular menstruation, as well as preparation method and application thereof |
| CN105079327A (en) * | 2015-09-25 | 2015-11-25 | 汤华淑 | Traditional Chinese medicine composition for treating amenorrhea |
| CN105797051A (en) * | 2016-05-27 | 2016-07-27 | 秦红星 | Traditional Chinese medicinal composition for treating amenorrhea caused by blood stagnation |
| CN105816786A (en) * | 2016-05-27 | 2016-08-03 | 秦红星 | Traditional Chinese medicine pills for treating blood stagnation menstrual block and preparing method thereof |
| CN105833164A (en) * | 2016-05-27 | 2016-08-10 | 秦红星 | Rice wine for treating amenorrhea due to stagnation of blood and preparation method of rice wine for treating amenorrhea due to stagnation of blood |
| CN105963517A (en) * | 2016-07-18 | 2016-09-28 | 郭建中 | Traditional Chinese medicine for treating secondary amenorrhea |
| CN106309654A (en) * | 2016-08-26 | 2017-01-11 | 徐洪安 | Medicine for treating irregular menstruation and preparation method thereof |
| CN108210829A (en) * | 2018-03-12 | 2018-06-29 | 河南万松宁云信息科技有限公司 | A kind of Chinese medicine composition for treating caused by hepatic stagnation qi stagnation irregular menstruation |
| CN109602830A (en) * | 2018-12-26 | 2019-04-12 | 周芳芳 | A kind of warm palace Chinese medicine preparation for treating problem of menstruation, the palace Wen Yangzi |
| CN110464785A (en) * | 2019-08-29 | 2019-11-19 | 梁健康 | It is a kind of for transdermal prescription of menalgia and preparation method thereof and application |
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