CN108853202A - A kind of pharmaceutical preparation that treating fatty liver and its application - Google Patents
A kind of pharmaceutical preparation that treating fatty liver and its application Download PDFInfo
- Publication number
- CN108853202A CN108853202A CN201810913391.4A CN201810913391A CN108853202A CN 108853202 A CN108853202 A CN 108853202A CN 201810913391 A CN201810913391 A CN 201810913391A CN 108853202 A CN108853202 A CN 108853202A
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- fatty liver
- pharmaceutical preparation
- chinese medicine
- ginseng
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- A—HUMAN NECESSITIES
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Abstract
The present invention discloses a kind of pharmaceutical preparation for treating fatty liver and its application, and the pharmaceutical preparation of the treatment fatty liver includes the medicament being prepared by following Chinese medicine material：Wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant.In technical solution provided by the invention, with this six kinds of Chinese medicine materials of wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant, pharmaceutical preparation is made in compounding, there is the effect of clearing heat and detoxicating, drying damp and strengthening spleen, promoting flow of qi and blood circulation, nourishing the liver dredging collateral,, short treating period significant to the therapeutic effect of fatty liver, and raw material is pure Chinese medicine, is had no toxic side effect.
Description
Technical field
The present invention relates to biomedicine technical field, in particular to a kind of pharmaceutical preparation for treating fatty liver and its application.
Background technique
The excessive lesion of fat deposition, is mankind's Metabolic syndrome in liver cell caused by fatty liver refers to due to various reasons
The common lesion of disease (Metabolic Syndrome, MS), MS are athero- including obesity, hypertension, hyperglycemia, hyperlipidemia, artery
A series of illnesss such as hardening, gout.Pathogenesis of fatty liver mechanism is not yet clear so far, and modern medicine thinks related with many factors,
As energy surplus, malnutrition, abnormalities of sugar/lipid metabolism, hormonal readiness exception, environment and genetics factor, lipid peroxidation damage,
Immune response anoxic and hepatic circulatory disturbance, is often drunk, drug and drug poisoning, gestation, hepatitis virus or other cause of disease body-sensings
Dye etc. plays a role in its pathogenic process.In recent years, with the improvement of living standards, by living habit, diet
The influence of structure, the movement many factors such as very few, China's fatty liver clinical incidence at rapid increase trend, clinical manifestation with
Liver cell fatty infiltration degree is directly proportional, although fatty liver is often considered as benign lesion, great mass of data show no matter the origin cause of formation
How, middle severe fatty liver patient has mild inflammation caused by fat accumulation or hepatocyte death, and part severe fatty liver is suffered from
Person can develop as different degrees of liver fibrosis, and serious liver fibrosis makes Liver on Judge Hardness be hardened i.e. cirrhosis.It is considered that fat
Liver is the cercinoma prophase pathologic change of part liver fibrosis or cirrhosis case.Fatty liver hepatopathy is just seriously threatening the health of compatriots, at
For the second largest hepatopathy for being only second to virus hepatitis, it is acknowledged as the common cause of invisible cirrhosis.
It should be pointed out that it is mild fatty liver that fat mass, which is more than 5%, it is moderate fatty liver more than 10%, more than 25%
For severe fatty liver.When fat mass total in liver is more than 30%, can be just checked with B ultrasound to be diagnosed as " fat by ultrasound diagnosis
Liver ".And Patients with Fatty Liver, total rouge amount up to 40%-50%, some up to 60% or more, mainly triglycerides and fatty acid, and
Phosphatide, cholesterol and cholesteryl ester are only a small amount of to be increased.
Under normal circumstances, fatty liver category invertibity disease, early diagnosing and treating in time can often restore normal.Currently, western
The treatment of medicine is mainly mainly to cure then, but treatment time is long, less effective with lipid-loweringing, liver protection, drop enzyme, and long-time service has not
Good reaction；Traditional Chinese medicine treats that fatty liver is turbid with invigorating the spleenization, dispersing stagnated hepatoqi, dispelling phlegm and eliminating dampness, nourishing the kidney and the liver, activating microcirculation and removing stasis medicinal, heat-clearing
Phlegm, qi and activate blood circulation, dispersing swelling and dissipating binds etc. are principle, there is certain curative effect, without side-effects.However, the rouge of sale treatment currently on the market
The types of drugs of fat liver is various, but is a lack of the good Chinese patent drug of real therapeutic effect.
Summary of the invention
The main object of the present invention is to propose a kind of pharmaceutical preparation for treating fatty liver and its application, it is desirable to provide Yi Zhongxiao
The pharmaceutical preparation of significant, without obvious toxic-side effects the treatment fatty liver of fruit.
To achieve the above object, the present invention proposes a kind of pharmaceutical preparation for treating fatty liver, including by following Chinese medicine material
The medicament being prepared：Wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant.
Preferably, the mass fraction of the wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant corresponds to 3~100
Part, 5~200 parts, 3~100 parts, 3~100 parts, 3~100 parts and 3~100 parts.
Preferably, the mass fraction of the wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant corresponds to 10~80
Part, 10~180 parts, 5~80 parts, 5~80 parts, 5~80 parts and 5~80 parts.
Preferably, the mass fraction of the wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant corresponds to 15~20
Part, 15~50 parts, 10~20 parts, 10~30 parts, 10~30 parts and 10~30 parts.
Preferably, the medicament is water decoction, powder, capsule, tablet, electuary or Liquor infusion.
The present invention also proposes a kind of drug of the pharmaceutical preparation in preparation treatment fatty liver for the treatment of fatty liver as described above
And the application in health care product.
In technical solution provided by the invention, in this six kinds of wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant
Medicine raw material, compounding are made pharmaceutical preparation, have the effect of clearing heat and detoxicating, drying damp and strengthening spleen, promoting flow of qi and blood circulation, nourishing the liver dredging collateral, to fat
The therapeutic effect of liver is significant, short treating period, and raw material is pure Chinese medicine, is had no toxic side effect.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Currently, the treatment for fatty liver, western modern medicine is mainly cured then with lipid-loweringing, liver protection, drop enzyme to be main, but treatment time
Long, less effective, long-time service has adverse reaction；Fatty liver is turbid with invigorating the spleenization for traditional Chinese medicine treatment, dispersing stagnated hepatoqi, resolving sputum are dispelled
Wet, nourishing the kidney and the liver, activating microcirculation and removing stasis medicinal, clearing heat and eliminating phlegm, qi and activate blood circulation, dispersing swelling and dissipating binds etc. are principle, have certain curative effect, make without pair
With.However, currently on the market sale treatment fatty liver types of drugs it is various, but be a lack of real therapeutic effect it is good at
Medicine.
Lack the good Chinese patent drug of real therapeutic effect in drug to solve the problems, such as existing treatment fatty liver, the present invention mentions
A kind of pharmaceutical preparation for treating fatty liver out, including the medicament being prepared by following Chinese medicine material：Wild watermelon, mantle, river
Rhizome of chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant, wherein the pharmacological action of the open country watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant
It is as follows：
Wild watermelon, alias caper, caper hook and pierce Capparis Spirrosa, drought resisting grass etc.；Acrid flavour, hardship, it is warm-natured, it is slightly poisonous；Effect
Wind-dispelling, cold dispelling, dehumidifying, swelling and pain relieving.For arthralgia, be production for treating the diseases such as cardiovascular and cerebrovascular disease and oligoleukocythemia
The base stock of drug, such as Sodium Ferulate, Limai capsule, Ferulic acid, it can play bodybuilding and guarantor simultaneously in human body
The effect of sheath skin.
Mantle, alias a mouthful, golden clock bodhi, red trumpet flower, Pestalotia funera, triumph fruit etc.；It is usually used in edible flavouring
The compatibility of " Thirteen Spice "；Acrid flavour, hardship, slightly warm in nature are slightly poisonous；Effect regulating qi, activating collateral, strengthening the spleen and stomach, dispellieg cold and dampness, preventing malaria are antipruritic.With
It is closed in prevention of malaria, influenza, indigestion, cold cough, pharyngo-laryngitis chronica, asthma, Senile Cor Pulmonale, pulmonary emphysema, muscle
Save wind-cold-dampness ache etc..
Rhizoma Chuanxiong, other mountain bring up poor, rhizome of chuanxiong Qiong, fragrant fruit, Hu Qiong, rhizome of chuanxiong Qiong, sparrow brain rhizome of chuanxiong, capital rhizome of chuanxiong, pass through rhizome of chuanxiong, raw Sichuan troops etc.；Acrid flavour micro-sweet,
It is warm-natured, it is nontoxic；Effect promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.It is dizzy to control air-cooled headache rotation, hypochondriac pain abdomen pain, arthritis muscle contraction, warp
It closes, has difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, amenorrhea and algomenorrhea, lump in the abdomen abdominal pain, pricking pain in the chest, tumbling and swelling,
Headache, rheumatic arthralgia.
Radix Angelicae Sinensis, alias is dry to return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, when angelica body, contain that angelica tail, Radix Angelicae Sinensis be bent, araliae cordatae
Deng；Pharmacological property is sweet in flavor, pungent, bitter, warm-natured, nontoxic；Effect replenishing and activating blood, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine.For all cards of the deficiency of blood, menstruation
Uncomfortable, menostasis, dysmenorrhea, abdominal mass knot be poly-, metrorrhagia and metrostaxis, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness, dry constipation of intestines, weight, ulcer sore after dysentery with bloody stool
Ulcer, traumatic injury.
Pseudo-ginseng, alias Radix Notoginseng, radix notoginseng, Panax pseudoginseng, mountain of papers Radix Notoginseng, literary state Radix Notoginseng etc.；Sweet and slightly bitter taste, it is warm-natured, it is nontoxic.
《A Supplement to the Compendium of Materia Medica》(1765)：Ginseng qi-tonifying first, Radix Notoginseng enrich blood first, taste with and function also etc., therefore claim Panax pseudoginseng, be
The most precious person of Chinese medicine.Effect nourishing blood and hemoslasis dissipates the stasis of blood, detumescence, analgesic therapy.For spitting blood, hemoptysis, bleeding from five sense organs or subcutaneous tissue, hematochezia, bloody flux, metrorrhagia and metrostaxis,
Abdominal mass, postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatic hemorrhage, carbuncle swells pain, be China's recipe " Yunnan Baiyao " it is main at
Point.
Silky ant, alias Polyhachis vicina Roger, polyrhachis vicina Roger, bitooth multi-ant, Camponotus jamponicus etc.；Taste is salty, mild-natured, has
Poison；Effect strengthens the body resistance to consolidate the constitution, tonifying kidney and strengthening yang, blood-nourishing honor muscle, dispelling wind and removing obstruction in the meridians.It takes orally for rheumatoid arthritis, rheumatism joint
Inflammation, ankylosing spondylitis, hemiplegia, numb in every limb, malignant tumour, pulmonary tuberculosis, chronic hepatitis and hepatitis B health carry
Person, asthma, premature ejaculation, impotence, post disease alopecia, insomnia, amnesia, tinnitus；Neurodermatitis, serious case of furuncle swelling and pain, chronic lower limb are controlled in external application
Ulcer, malignant sore, snake bite are decocted as a steam-wash or are embrocated.
In technical solution provided by the invention, in this six kinds of wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant
Pharmaceutical preparation is made in medicine raw material, compounding, there is eliminating cold to remove dampness, invigorating the spleen to moisturize, qi and activate blood circulation and other effects, imitates to the treatment of fatty liver
Fruit is significant, short treating period, and raw material is pure Chinese medicine, is had no toxic side effect, and low in cost, is easy to be accepted by patients.
As an embodiment provided by the invention, in the pharmaceutical preparation of the treatment fatty liver, each Chinese medicine material
Proportion it is as follows：The open country watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 3~100 parts, 5
~200 parts, 3~100 parts, 3~100 parts, 3~100 parts and 3~100 parts.
As a preferred embodiment provided by the invention, in the pharmaceutical preparation of the treatment fatty liver, it is each it is described in
The proportion of medicine raw material is as follows：The open country watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 10~
80 parts, 10~180 parts, 5~80 parts, 5~80 parts, 5~80 parts and 5~80 parts.
Further, in the pharmaceutical preparation of the treatment fatty liver, the proportion of each Chinese medicine material is further preferred
For：The open country watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 15~20 parts, 15~50 parts,
10~20 parts, 10~30 parts, 10~30 parts and 10~30 parts.
Pharmaceutical preparation of the present invention compares according to any one in Chinese medicine material ratio range provided above is specific
Example is prepared with postponing, and can be prepared into common Chinese medicine pharmaceutically dosage form, preferably peroral dosage form, for example, water decoction, Liquor infusion,
Medicinal tea, pill, tablet, powder or electuary etc. form can choose carrier or auxiliary material with this field routine in the preparation
Whether combination or not, the pharmaceutical preparation containing Chinese medicine material provided by the invention can be made, in embodiments of the present invention
More preferably water decoction, powder, capsule, tablet, electuary or Liquor infusion have the advantages that preparation method simplicity.
Wherein, the water decoction is that above-mentioned Chinese medicine material is added water to cook to a kind of preparation directly drunk afterwards in proportion, is had
There is the features such as absorption is fast, effect is rapid, plus-minus is flexible, with strong points；The Liquor infusion is to immerse above-mentioned Chinese medicine material in wine,
By the regular hour, a kind of preparation then drunk in wine, that is, usually said liquid medicine are leached to pharmacological property, by means of wine
The effect of activating blood and relaxing tendons possessed by itself, the effect of enhancing the promoting qi circulation and removing obstruction in the collateral of the pharmaceutical preparation, and then improve to fatty liver
Therapeutic effect；The powder is that above-mentioned Chinese medicine material is pulverized into powder to a kind of manufactured preparation, and water can be used when taking
It is taken after mixing with liquid or decoction is taken, the absorption for having both decoction is fast, effect is rapidly and the features such as the dosage of pill is small, easy to carry；
The capsule is to be fitted into manufactured a kind of preparation in capsule after being pulverized into powder above-mentioned Chinese medicine material, is directly swallowed i.e.
Can, have the characteristics that convenient to take, easy to carry；The tablet is after being pulverized into powder above-mentioned Chinese medicine material by tabletting
A kind of preparation that technique is compressed into tablet form, it is easy to carry and use；The electuary is to be pulverized into powder above-mentioned Chinese medicine material,
Then it uses ethyl alcohol or water etc. that can be taken after being infused in hot water or decoction the preparations of Instant Drinks as after Extraction solvent extraction by one kind made from spray drying, drinks
With extremely convenient, can directly be brewed with boiling water when taking, some can also decoct.
It should be noted that those described above pharmaceutical dosage form is in the preparation, using Chinese medicine customary preparation methods into
Row preparation, technological parameter during the preparation process can adjust accordingly according to the actual situation, so that drug obtained
The drug effect of preparation remains most preferably, for example, during water decoction is made after adding water to cook the Chinese medicine material in proportion,
Amount of water, which is subject to, does not cross raw material, can also add in right amount, when decocting, can first be boiled with intense fire to boiling, then again with mild fire
The dregs of a decoction are filtered out after continuing decoction 25~30 minutes, water decoction is made；Or it can also be right according to the number of practical decoction amount
Amount of water and decocting time should be adjusted, keeps optimal water decoction to obtain drug effect.
Drug and guarantor the present invention also provides the pharmaceutical preparation for the treatment of fatty liver as described above in preparation treatment fatty liver
Application in strong product, the pharmaceutical preparation can be used as the drug and health care product that active constituent is used to prepare treatment fatty liver,
Such as sugar coated tablet is made in conjunction with its medically acceptable carrier in the pharmaceutical preparation, it can be to avoid drug sheet when swallowing
Perhaps bitter taste etc. causes patient to swallow the pharmaceutical preparation of difficult problem or selection decocting dosage form to the astringent taste of body, is added
The additives such as corrigent, bacteriostatic agent are prepared into oral solution, in this way, avoiding patient in the drug for directly taking decocting dosage form
When preparation, since the mouthfeel bitterness of water decoction is without easy entrance and the problem of drink.
Technical solution of the present invention is described in further detail below in conjunction with specific embodiment, it should be understood that following real
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
Embodiment 1
(1) Chinese medicine material weighs：10 parts of wild watermelon, 30 parts of mantle, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng with
And 10 parts of silky ant.
(2) preparation of pharmaceutical preparation：Weighed Chinese medicine material is put into Chinese medicinal pot, adds water to and does not cross medicinal material, then first
It boils with high heat to boiling, then is adjusted to and continues boiling by slow fire 25min, then filter out decoction of medicinal ingredients, water decoction is made.
Embodiment 2
(1) Chinese medicine material weighs：15 parts of wild watermelon, 50 parts of mantle, 10 parts of Rhizoma Chuanxiong, 20 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng with
And 20 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powdered, system
Obtain powder.
Embodiment 3
(1) Chinese medicine material weighs：10 parts of wild watermelon, 50 parts of mantle, 20 parts of Rhizoma Chuanxiong, 20 parts of Radix Angelicae Sinensis, 10 parts of pseudo-ginseng with
And 20 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
The mixed liquor that powder water and ethyl alcohol mix in equal volume is extracted, and it is powdered then to carry out spray drying acquisition to extraction product
Product, be made electuary.
Embodiment 4
(1) Chinese medicine material weighs：10 parts of wild watermelon, 50 parts of mantle, 10 parts of Rhizoma Chuanxiong, 20 parts of Radix Angelicae Sinensis, 20 parts of pseudo-ginseng with
And 20 parts of silky ant.
(2) preparation of pharmaceutical preparation：It is put into glass jar after weighed Chinese medicine material is cleaned, white wine is then added, often
White wine 2.5L is added in the Chinese medicine material of 240g, impregnates after three weeks, is made Liquor infusion (each 20mL when taking).
Embodiment 5
(1) Chinese medicine material weighs：20 parts of wild watermelon, 15 parts of mantle, 15 parts of Rhizoma Chuanxiong, 30 parts of Radix Angelicae Sinensis, 30 parts of pseudo-ginseng with
And 30 parts of silky ant.
(2) preparation of pharmaceutical preparation：Weighed Chinese medicine material is put into Chinese medicinal pot, adds water to and does not cross medicinal material, then first
It boils with high heat to boiling, then is adjusted to and continues boiling by slow fire 25min, then filter out decoction of medicinal ingredients, water decoction is made.
Embodiment 6
(1) Chinese medicine material weighs：18 parts of wild watermelon, 10 parts of mantle, 5 parts of Rhizoma Chuanxiong, 3 parts of Radix Angelicae Sinensis, 5 parts of pseudo-ginseng and black
20 parts of ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
Powder is fitted into capsule, and capsule is made.
Embodiment 7
(1) Chinese medicine material weighs：40 parts of wild watermelon, 60 parts of mantle, 20 parts of Rhizoma Chuanxiong, 80 parts of Radix Angelicae Sinensis, 50 parts of pseudo-ginseng with
And 100 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
Sheet is made by tabletting in powder, and tablet is made.
Embodiment 8
(1) Chinese medicine material weighs：60 parts of wild watermelon, 120 parts of mantle, 80 parts of Rhizoma Chuanxiong, 60 parts of Radix Angelicae Sinensis, 40 parts of pseudo-ginseng with
And 5 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powdered, system
Obtain powder.
Embodiment 9
(1) Chinese medicine material weighs：80 parts of wild watermelon, 180 parts of mantle, 50 parts of Rhizoma Chuanxiong, 30 parts of Radix Angelicae Sinensis, 80 parts of pseudo-ginseng with
And 60 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
Powder is fitted into capsule, and capsule is made.
Embodiment 10
(1) Chinese medicine material weighs：3 parts of wild watermelon, 5 parts of mantle, 100 parts of Rhizoma Chuanxiong, 5 parts of Radix Angelicae Sinensis, 100 parts of pseudo-ginseng and
80 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
Sheet is made by tabletting in powder, and tablet is made.
Embodiment 11
(1) Chinese medicine material weighs：100 parts of wild watermelon, 200 parts of mantle, 3 parts of Rhizoma Chuanxiong, 100 parts of Radix Angelicae Sinensis, 3 parts of pseudo-ginseng with
And 3 parts of silky ant.
(2) preparation of pharmaceutical preparation：Drying is cleaned after weighed Chinese medicine material is mixed, and is then comminuted into powder, then will
The mixed liquor that powder water and ethyl alcohol mix in equal volume is extracted, and it is powdered then to carry out spray drying acquisition to extraction product
Product, be made electuary.
By taking the pharmaceutical preparation of decocting dosage form prepared by above-described embodiment 5 as an example, to treatment fatty liver provided by the invention
The curative effect that pharmaceutical preparation treatment fatty liver is controlled is verified, the treatment clinical trial including clinical case and typical case, test
Method and result are as follows：
1, clinical case
(1) case selection：Select the severe fatty liver (including Alcoholic and nonalcoholic fatty liver) patient 100 made a definite diagnosis
It being observed, patient is randomly divided into two groups, treatment group 50, wherein male 35, and women 15, average age 45 years old；Control
50 are organized, wherein male 34, women 16, average age 46 years old.Two groups of qualifications are almost the same, no significant difference, and having can
Compare property.
(2) diagnostic criteria：Main Diagnosis index is liver B ultrasound：It can be seen that severe fatty liver reflection configuration.
(3) treatment method：The pharmaceutical preparation of the decocting dosage form of the preparation of the embodiment of the present invention 5 is taken by treatment group, warmly takes after meal,
1 dose is respectively taken daily morning and evening, and every dose pan-fried that 300mL is taken in two divided doses；Control group take essentiale capsule (treating acute and chronic hepatitis,
Cirrhosis, toxic metabolic hepatopathy, hepatic steatosis caused by a variety of causes, bile pent-up, the prevention of gall stone, every
Capsule contains essential phospholipid 300mg, vitamin B1 6mg, vitamin B2 6mg, vitamin B6 6mg, vitamin B12 6ug, cigarette
Amide 30mg and alpha-tocopherol acetate 6mg), 2 tablets each time, twice daily take orally；Two groups of patients keep on a diet, and deactivate its other medicine
Object counted curative effect after 3 months.
(4) efficacy determination：A, it fully recovers：B ultrasound shows that fatty liver reflected echo pattern disappears；B, effectively：B ultrasound shows fatty liver reflection
Wave mode weakens to moderate or slight；C, invalid：Liver B-type ultrasonography has no improvement.Curative effect statistical result such as the following table 1 institute
Show.
The curative effect statistical result of 1 treatment group of table and control group case
| Effective number (example) | Significant figure (example) | Invalid number (example) | Obvious effective rate (%) | Efficient (%) | |
| Treatment group | 40 | 9 | 1 | 80 | 98 |
| Control group | 23 | 16 | 11 | 46 | 78 |
By the statistical result in table 1 it is found that compared to the existing essentiale capsule for treating fatty liver, embodiment of the present invention system
The curative effect of the pharmaceutical preparation of standby treatment fatty liver is more significant, and has no toxic side effect, and fully recovers case follow-up 1 year without recurrence, advises
It controls fat intake, appropriate reinforcement movement.
2, typical case
Case one：Mr. Wei, male, 48 years old, meat product was eaten in especially happiness, and no drinking, figure is partially fat, adhered to playing basketball daily, and 6
B ultrasound discovery has fatty liver before year；Nearly annual physical examination in 3 years, each physical examination report is all severe fatty liver, hyperlipidemia；It is close several
Year activity is just pant, and leg acid is out of strength, is easy burnout.Take the embodiment of the present invention 5 preparation decocting dosage form pharmaceutical preparation, one
Secondary one, twice daily, after three months, B ultrasound further consultation, fatty liver disappears, and blood lipid is back to normal, and fatiguability phenomenon is clearly better,
Other adverse reactions are seen at end, and B ultrasound check is normal after 1 year, and blood lipid is normal, and liver function is normal.
Case two：Mrs Liu, female, 42 years old, patient was fatter, and usually activity is few, was fond of greasy, often there is bitter taste, right flank
Secret anguish, poor memory are fallen asleep slow, and disposition is easily anxious, defecates viscous not well, the soft no mass that abdomen is pressed greatly, lymph node end is touched.B
Super display：Fatty liver.The pharmaceutical preparation of the decocting dosage form of the preparation of the embodiment of the present invention 5 is taken, it is primary one, twice a day, it even served
All cards remove after 30 days, continue after taking 2 months, and further consultation B ultrasound shows that liver is normal, and liver function is normal.Follow-up after 1 year, all
Good, other exceptions are seen at end.
In conclusion it is provided by the invention treatment fatty liver pharmaceutical preparation, with wild watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis,
Pseudo-ginseng and this six kinds of Chinese medicines of silky ant are that agent is made in raw material compounding, and, short treating period significant to the therapeutic effect of fatty liver takes one
The moon can take effect, and liver index and functional rehabilitation are normal after continuously taking three months, not find toxic side effect and adverse reaction, and
And preparation method is easy, low in cost, is easy to be accepted by patients.
The above is only a preferred embodiment of the present invention, is not intended to limit the scope of the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc. should all be included within the scope of the present invention.
Claims (6)
1. a kind of pharmaceutical preparation for treating fatty liver, which is characterized in that including the medicament being prepared by following Chinese medicine material：It is wild
Watermelon, mantle, Rhizoma Chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant.
2. the pharmaceutical preparation for the treatment of fatty liver as described in claim 1, which is characterized in that the open country watermelon, mantle, river
Rhizome of chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 3~100 parts, 5~200 parts, 3~100 parts, 3~100 parts, 3~
100 parts and 3~100 parts.
3. the pharmaceutical preparation for the treatment of fatty liver as claimed in claim 2, which is characterized in that the open country watermelon, mantle, river
Rhizome of chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 10~80 parts, 10~180 parts, 5~80 parts, 5~80 parts, 5~80
Part and 5~80 parts.
4. the pharmaceutical preparation for the treatment of fatty liver as claimed in claim 3, which is characterized in that the open country watermelon, mantle, river
Rhizome of chuanxiong, Radix Angelicae Sinensis, pseudo-ginseng and silky ant mass fraction correspond to 15~20 parts, 15~50 parts, 10~20 parts, 10~30 parts, 10~
30 parts and 10~30 parts.
5. the pharmaceutical preparation of the treatment fatty liver as described in Claims 1-4 any one, which is characterized in that the medicament is
Water decoction, powder, capsule, tablet, electuary or Liquor infusion.
6. a kind of pharmaceutical preparation of the treatment fatty liver as described in claim 1 to 5 any one treats or prevents rouge in preparation
The drug of fat liver and the application in health care product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810913391.4A CN108853202A (en) | 2018-08-10 | 2018-08-10 | A kind of pharmaceutical preparation that treating fatty liver and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810913391.4A CN108853202A (en) | 2018-08-10 | 2018-08-10 | A kind of pharmaceutical preparation that treating fatty liver and its application |
Publications (1)
| Publication Number | Publication Date |
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| CN108853202A true CN108853202A (en) | 2018-11-23 |
Family
ID=64317753
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| CN201810913391.4A Pending CN108853202A (en) | 2018-08-10 | 2018-08-10 | A kind of pharmaceutical preparation that treating fatty liver and its application |
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| CN101708237A (en) * | 2009-12-28 | 2010-05-19 | 潘畅 | Medicinal composition used for tonifying qi and invigorating pulse, preparation method thereof and application thereof |
| CN101953910A (en) * | 2010-10-21 | 2011-01-26 | 西南大学 | Coptis alkaloid and ferulic acid compound with glucose-lowering effect |
| CN104225115A (en) * | 2014-09-29 | 2014-12-24 | 上海市青浦区中医医院 | Medicine for treating fatty liver disease and application of medicine |
| CN104689218A (en) * | 2015-03-31 | 2015-06-10 | 周冠旻 | Traditional Chinese medicine composition for treating fatty liver |
| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708237A (en) * | 2009-12-28 | 2010-05-19 | 潘畅 | Medicinal composition used for tonifying qi and invigorating pulse, preparation method thereof and application thereof |
| CN101953910A (en) * | 2010-10-21 | 2011-01-26 | 西南大学 | Coptis alkaloid and ferulic acid compound with glucose-lowering effect |
| CN104225115A (en) * | 2014-09-29 | 2014-12-24 | 上海市青浦区中医医院 | Medicine for treating fatty liver disease and application of medicine |
| CN104689218A (en) * | 2015-03-31 | 2015-06-10 | 周冠旻 | Traditional Chinese medicine composition for treating fatty liver |
| CN107469156A (en) * | 2017-09-30 | 2017-12-15 | 焦德超 | A kind of film covering type Y type biliary tract prosthesises for being locally covered with chemotherapeutics |
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