CN108852934A - The application of the method and its compound of tea polyphenols and chlorophyll in cosmetics is extracted in a kind of green tea - Google Patents
The application of the method and its compound of tea polyphenols and chlorophyll in cosmetics is extracted in a kind of green tea Download PDFInfo
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- CN108852934A CN108852934A CN201810823892.3A CN201810823892A CN108852934A CN 108852934 A CN108852934 A CN 108852934A CN 201810823892 A CN201810823892 A CN 201810823892A CN 108852934 A CN108852934 A CN 108852934A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention relates to the application of the method and its compound of tea polyphenols and chlorophyll in cosmetics is extracted in a kind of green tea, green tea fresh leaf is cleaned by ultrasonic, is finished, pulverization process, using ultrasonic-leaching method, 85% ethyl alcohol is added in leaching liquor, with ultrafiltration membrance filter, filtrate is concentrated to give high-purity tea polypenols and chlorophyll product.By mechanical crushing and cavitation by ultrasonic wave, formation, increase and the closure in liquid hole generate great shock wave and shearing force, clasmatosis are made to release object intracellular the present invention.Have many advantages, such as that the time is short, temperature is low, recovery rate is high.Better than traditional extraction method in terms of concentration, recovery rate and extraction rate.Pass through the process conditions of ultrasonic wave extraction tea polyphenols and chlorophyll; product yield improves about 30% than Conventional solvents extraction method; using the tea polyphenols and chlorophyll compound extracted in green tea in cosmetics, anti-oxidant, resistant to pollution protective effect is played to skin, realizes the effect of cosmetology.
Description
[technical field]
The present invention relates to technical field of biological extraction, tea polyphenols and chlorophyll are extracted in specifically a kind of green tea
Method and its application in cosmetics.
[background technique]
Green tea (Green Tea) is one of the main teas of China, and green tea is not fermented manufactured tea, is remained fresh
The natural materials of leaf, the tea polyphenols contained, catechin, chlorophyll, caffeine, amino acid, vitamins and other nutritious components are also more.
These natural nutrition compositions in green tea have special-effect to anti-aging, anti-cancer, anticancer, sterilization, anti-inflammatory etc..Therefore always with
Taking green tea all is the top grade of body-building, face-care.
Green tea anti-aging
Help to delay senescence, it is the removing of human free radical that tea polyphenols, which have very strong inoxidizability and physiological activity,
Agent.Research has shown that 1 milligram of tea polyphenols removing is equivalent to 9 microgram superoxides discriminations to the efficiency of the harmful excessive free radicals of people's human body
Change enzyme, is much higher than other allied substances.Tea polyphenols have blocking peroxidatic reaction of lipid, the effect of scavenging capacity enzyme.According to Japan
Tian Tuoyong test result difficult to understand, it was demonstrated that the anti-aging effects of tea polyphenols are 18 times stronger than vitamin E.
Carcinogenesis
Facilitate prevention and anticancer.Tea polyphenols can block a variety of carcinogen in vivo synthesis such as ammonium nilrite, and have
The effect of having direct killing cancer cell and improving human body immunocompetence.According to the relevant information, the tea polyphenols in tealeaves, to stomach
The prevention and adjuvant treatment of the kinds cancers such as cancer, intestinal cancer, there is benifit.
Beauty and skin care
Tea polyphenols are water-soluble substances, and the greasy of face can be removed by being washed one's face with it, restrain pore, have disinfection, sterilize, is anti-
Skin aging reduces damage and other effects of the ultraviolet radiation in daylight to skin.
Lipid-loweringing
It is aid digestion to facilitate lipid-loweringing, the Tang Dynasty《Bencao Shiyi》In have the record of " long food makes us thin " to the effect of tea.China
There is saying for " can not one day without tea " in borderland ethnic group.Because tealeaves has important effect that is aid digestion and reducing fat, with current
Fashion language is said, just contributes to " lose weight ".This is because the caffeine in tealeaves can improve the secretory volume of gastric juice, can help
Digestion.In addition, catechin rich in green tea, helps to slim the abdomen.
Currently, mainly having following three kinds using the method for extracting separating high-purity tea polyphenols and chlorophyll in production
Method:1 solvent extraction method, 2 ion catch electron microscopies, 3 post separation the preparation methods.But obtained chlorophyll, tea polyphenols equal size produce
Product purity is not high, and appearance luster is pale brown or blackish green, chemical component remains and impurity is also more, and processing time is longer;
Therefore it improves the content of product and purity and improves production efficiency and be particularly important.
[summary of the invention]
Present invention aim to solve above-mentioned deficiency, and provides and extract tea polyphenols and chlorophyll in a kind of green tea
Method and its applied in cosmetics.Using the tea polyphenols in ultrasonic wave extraction green tea, in concentration, recovery rate and extraction rate
Aspect is better than traditional extraction method.By the process conditions of ultrasonic wave extraction tea polyphenols, product yield is than Conventional solvents extraction method
Improve about 30%.Using the tea polyphenols and chlorophyll extracted in green tea in cosmetics, skin is played anti-oxidant, resistant to pollution
The effect of cosmetology is realized in protective effect.The invention is suitable for the cosmetics of any skin.Green-tea extract:Green tea mentions
Taking object is the active constituent extracted from green tea blade, is contained a large amount of tea polyphenols (catechin).Tea polyphenols have anti-oxidant, clear
The effects of except free radical.Largely scientific investigations showed that, the Antioxidants in green tea are higher than many vegetables and fruit, and
The oxidation resistance of tea polyphenols is more stronger than vitamin C or E.Fukushima once reported that long-term drinking green tea can reduce face
Pigment spot, spot caused by especially being irradiated by UV.Meanwhile Kyung is reported, small particle (PM) pollution in air can be led
Potential skin disease is caused, and polyphenoils can effectively treat the skin disease as caused by small particle (PM).Chlorophyll:Ye Lv
Element is higher plant and other all a kind of green pigments that can be carried out photosynthetic organism and contain.It is relevant with chlorophyll
Research once obtained the Nobel Prize three times.There is very strong antioxidation and gene to protect for many scientific research surfaces, chlorophyll
Shield effect.Suparmi once reported that the powerful anti-oxidant pressure of chlorophyll can effectively inhibit the DNA as caused by free radical to damage
Wound and lipid peroxidation.The multidigits such as Negishi scientist once reported the ability that natural chlorophyll has suppressor toxicity.
A kind of method for extracting tea polyphenols and chlorophyll in green tea is designed to achieve the above object, is included the following steps:
1) green tea fresh leaf is cleaned by ultrasonic, ultrasonic power be 500~1500W, 23~30 DEG C of ultrasonic temperature, when ultrasonic
Between 6~16min;
2) water-removing processing is carried out to the blade after cleaning, is finished with 100~150 DEG C of steam, fixation time 30~150
Second;
3) blade after water-removing is crushed, crushing specification is 3~21 mesh;
4) broken blade and water solid-liquid ratio are 1:150~180g/ml, using ultrasonic-leaching method, by ultrasonic wave
The mechanical crushing and cavitation of broken instrument, formation, increase and the closure in liquid hole generate great shock wave and shearing
Power makes clasmatosis release object intracellular, collects leaching liquor;
5) NaCl is added in leaching liquor, NaCl additional amount is the 10~20% of supernatant weight, stirs evenly, is fallen
Enter separatory funnel, stratification removes lower layer's water phase, takes upper layer;
6) 85% ethyl alcohol of 1~5 times of volume is added in upper layer, and with ultrafiltration membrance filter, filtrate is concentrated into thick;
7) it is slowly added to dehydrated alcohol in concentrate, vibrates, until stopping being added when white precipitate amount of precipitation is without significant change
Dehydrated alcohol, filtering, filtrate are concentrated to give high-purity tea polypenols and chlorophyll product.
The ultrasonic power of Ultrasonic Cell Disruptor is 190~210W in the step 4), and ultrasonic time is 13~15min, water-bath
Temperature is 43 DEG C, water bath time 45min, extracts 40~90min.
Tea polyphenols are extracted in the green tea and chlorophyll is preparing the application in cosmetics.
The present invention compared with the existing technology, using ultrasonic-leaching method, by the mechanical crushing and cavitation of ultrasonic wave,
Using the formation, increase and closure in liquid hole, great shock wave and shearing force are generated, releases clasmatosis intracellular
Object.The method has many advantages, such as that the time is short, temperature is low, recovery rate is high for extracting.It is more using the tea in ultrasonic wave extraction green tea
Phenol, better than traditional extraction method in terms of concentration, recovery rate and extraction rate.Pass through the technique item of ultrasonic wave extraction tea polyphenols
Part, product yield improve about 30% than Conventional solvents extraction method.The anti-oxidant and gene protection of green-tea extract and chlorophyll is made
With.In vitro in test and cell tests, 1. green tea extract tea polyphenols and chlorophyll significantly inhibits oxygen radical for skin
The damage of skin horn cell.And improve the cell survival rate under UV irradiation.2. green tea extracts tea polyphenols and chlorophyll is effective
Protect horn cell, significantly inhibit damage of the PM2.5 for skin keratinocytes.Green tea mentions tea polyphenols and chlorophyll
Cosmetic result clinical trial.First group:Participation 30 women of experiment number, the age 18-38 years old.Continuous use containing tea polyphenols and
The beautifying liquid of chlorophyll 28 days, average everyone uses 2 times daily.After one month, subject's skin moisturizing degree, glossiness is shown
It writes and is promoted, microgroove is reduced, and color spot subtracts light.93% consumer indicates to see highly significant/more significant effect, obviously feel after use
To comfortable, soft, the colour of skin is more evenly, more glossy, is worthy of popularization.
[specific embodiment]
Embodiment 1:
1) green tea fresh leaf is cleaned by ultrasonic, ultrasonic power 500W, 23 DEG C of ultrasonic temperature, ultrasonic time 6min;
2) water-removing processing is carried out to the blade after cleaning, is finished with 100 DEG C of steam, fixation time 30 seconds;
3) blade after water-removing is crushed, crushing specification is 3 mesh;
4) broken blade and water solid-liquid ratio are 1:150g/ml, using ultrasonic-leaching method, by sonicator
Mechanical crushing and cavitation, formation, increase and the closure in liquid hole generate great shock wave and shearing force, makes thin
Born of the same parents are broken to release object intracellular, and the ultrasonic power of Ultrasonic Cell Disruptor is 190W, and ultrasonic time 13min, bath temperature is 43 DEG C,
Water bath time is 45min, and extraction 40min collects leaching liquor;
5) it is added NaCl in leaching liquor, NaCl additional amount is the 10% of supernatant weight, is stirred evenly, and is poured into point
Liquid funnel, stratification remove lower layer's water phase, take upper layer;
6) 85% ethyl alcohol of 2 times of volumes is added in upper layer, and with ultrafiltration membrance filter, filtrate is concentrated into thick;
7) it is slowly added to dehydrated alcohol in concentrate, vibrates, until stopping being added when white precipitate amount of precipitation is without significant change
Dehydrated alcohol, filtering, filtrate are concentrated to give high-purity tea polypenols and chlorophyll product.
Embodiment 2:
1) green tea fresh leaf is cleaned by ultrasonic, ultrasonic power 1000W, 25 DEG C of ultrasonic temperature, ultrasonic time 10min;
2) water-removing processing is carried out to the blade after cleaning, is finished with 125 DEG C of steam, fixation time 100 seconds;
3) blade after water-removing is crushed, crushing specification is 15 mesh;
4) broken blade and water solid-liquid ratio are 1:160g/ml, using ultrasonic-leaching method, by sonicator
Mechanical crushing and cavitation, formation, increase and the closure in liquid hole generate great shock wave and shearing force, makes thin
Born of the same parents are broken to release object intracellular, and the ultrasonic power of Ultrasonic Cell Disruptor is 200W, and ultrasonic time 14min, bath temperature is 43 DEG C,
Water bath time is 45min, extracts 65min, collects leaching liquor;
5) it is added NaCl in leaching liquor, NaCl additional amount is the 15% of supernatant weight, is stirred evenly, and is poured into point
Liquid funnel, stratification remove lower layer's water phase, take upper layer;
6) 85% ethyl alcohol of 4 times of volumes is added in upper layer, and with ultrafiltration membrance filter, filtrate is concentrated into thick;
7) it is slowly added to dehydrated alcohol in concentrate, vibrates, until stopping being added when white precipitate amount of precipitation is without significant change
Dehydrated alcohol, filtering, filtrate are concentrated to give high-purity tea polypenols and chlorophyll product.
The present invention is simultaneously not limited to the embodiments described above, other any without departing from spiritual essence and principle of the invention
Changes, modifications, substitutions, combinations, simplifications made by lower, should be equivalent substitute mode, are included in protection model of the invention
Within enclosing.
Claims (3)
1. extracting the method for tea polyphenols and chlorophyll in a kind of green tea, which is characterized in that include the following steps:
1) green tea fresh leaf is cleaned by ultrasonic, ultrasonic power be 500~1500W, 23~30 DEG C of ultrasonic temperature, ultrasonic time 6
~16min;
2) water-removing processing is carried out to the blade after cleaning, is finished with 100~150 DEG C of steam, fixation time 30~150 seconds;
3) blade after water-removing is crushed, crushing specification is 3~21 mesh;
4) broken blade and water solid-liquid ratio are 1:150~180g/ml, using ultrasonic-leaching method, by ultrasonic disruption
The mechanical crushing and cavitation of instrument, formation, increase and the closure in liquid hole, generate great shock wave and shearing force, make
Clasmatosis releases object intracellular, collects leaching liquor;
5) it is added NaCl in leaching liquor, NaCl additional amount is the 10~20% of supernatant weight, is stirred evenly, and is poured into point
Liquid funnel, stratification remove lower layer's water phase, take upper layer;
6) 85% ethyl alcohol of 1~5 times of volume is added in upper layer, and with ultrafiltration membrance filter, filtrate is concentrated into thick;
7) it is slowly added to dehydrated alcohol in concentrate, vibrates, until stopping being added when white precipitate amount of precipitation is without significant change anhydrous
Ethyl alcohol, filtering, filtrate are concentrated to give high-purity tea polypenols and chlorophyll product.
2. extracting the method for tea polyphenols and chlorophyll in green tea as described in claim 1, it is characterised in that:The step 4)
The ultrasonic power of middle Ultrasonic Cell Disruptor is 190~210W, and ultrasonic time is 13~15min, and bath temperature is 43 DEG C, water bath time
For 45min, 40~90min is extracted.
3. extracting tea polyphenols in a kind of green tea as described in claim 1 and chlorophyll compound preparing answering in cosmetics
With.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109503606A (en) * | 2018-12-04 | 2019-03-22 | 界首市万花巢生物科技有限公司 | A kind of small device and extracting method extracting chlorophyll from green tea |
CN109620788A (en) * | 2019-01-30 | 2019-04-16 | 周忠平 | A kind of process for extracting tea polyphenol and its application in beautifying whitening liquid |
CN113604070A (en) * | 2021-09-08 | 2021-11-05 | 方竹生物科技(清远)有限公司 | High-purity separation method and equipment for physically extracting tea pigment |
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CN103923091A (en) * | 2014-04-22 | 2014-07-16 | 山西大学 | Method for extracting chlorophyll |
CN104970147A (en) * | 2015-04-17 | 2015-10-14 | 中华全国供销合作总社杭州茶叶研究所 | Preparation method of high-fluorine high-chlorophyll tea leaf extract |
CN108014213A (en) * | 2017-12-11 | 2018-05-11 | 福州大学 | A kind of method for rapidly and efficiently extracting tea polyphenols in tealeaves leftover bits and pieces |
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2018
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Patent Citations (4)
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US20050287278A1 (en) * | 2004-06-24 | 2005-12-29 | Xel Herbaceuticals, Inc. | Green tea formulations and methods of preparation |
CN103923091A (en) * | 2014-04-22 | 2014-07-16 | 山西大学 | Method for extracting chlorophyll |
CN104970147A (en) * | 2015-04-17 | 2015-10-14 | 中华全国供销合作总社杭州茶叶研究所 | Preparation method of high-fluorine high-chlorophyll tea leaf extract |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109503606A (en) * | 2018-12-04 | 2019-03-22 | 界首市万花巢生物科技有限公司 | A kind of small device and extracting method extracting chlorophyll from green tea |
CN109620788A (en) * | 2019-01-30 | 2019-04-16 | 周忠平 | A kind of process for extracting tea polyphenol and its application in beautifying whitening liquid |
CN109620788B (en) * | 2019-01-30 | 2022-03-25 | 周忠平 | Tea polyphenol extraction process and application thereof in beauty and whitening liquid |
CN113604070A (en) * | 2021-09-08 | 2021-11-05 | 方竹生物科技(清远)有限公司 | High-purity separation method and equipment for physically extracting tea pigment |
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