CN108850407A - A kind of chewing gum of the extract containing hairystalk loosestrife herb is improving the application on oral environment - Google Patents
A kind of chewing gum of the extract containing hairystalk loosestrife herb is improving the application on oral environment Download PDFInfo
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- CN108850407A CN108850407A CN201810946666.4A CN201810946666A CN108850407A CN 108850407 A CN108850407 A CN 108850407A CN 201810946666 A CN201810946666 A CN 201810946666A CN 108850407 A CN108850407 A CN 108850407A
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- chewing gum
- loosestrife herb
- hairystalk loosestrife
- extract
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- 235000015218 chewing gum Nutrition 0.000 title claims abstract description 43
- 229940112822 chewing gum Drugs 0.000 title claims abstract description 40
- 241000219991 Lythraceae Species 0.000 title claims abstract description 31
- PCSWXVJAIHCTMO-UHFFFAOYSA-P dequalinium Chemical compound C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 PCSWXVJAIHCTMO-UHFFFAOYSA-P 0.000 claims abstract description 24
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000011159 matrix material Substances 0.000 claims description 13
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- 235000019441 ethanol Nutrition 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
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- 229920002472 Starch Polymers 0.000 claims description 7
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- 239000000605 aspartame Substances 0.000 claims description 7
- 235000010357 aspartame Nutrition 0.000 claims description 7
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- 229960003438 aspartame Drugs 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
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- 235000010447 xylitol Nutrition 0.000 claims description 7
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- 229960002675 xylitol Drugs 0.000 claims description 7
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- 208000006558 Dental Calculus Diseases 0.000 description 3
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Confectionery (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of chewing gums of extract containing hairystalk loosestrife herb to improve the application on oral environment, belongs to chewing gum technical field.Chewing gum is specially made using hairystalk loosestrife herb extract, to improve oral environment, the chewing gum is made of Dequavet, hairystalk loosestrife herb extract and partial supplementary material.Test proves that chewing gum of the present invention can be effectively improved oral environment, especially will improve sterilizing ability after hairystalk loosestrife herb extract and Dequavet mixture, mushroom living environment is destroyed, especially suitable for there is oral inflammation patient use.
Description
Technical field
The present invention relates to the chewing gums of daily necessities technical field more particularly to a kind of extract containing hairystalk loosestrife herb to change
Application on kind oral environment.
Background technique
Chewing gum is deep by a kind of favorite carbohydrate of the people of the world, and presently commercially available chewing gum is by natural gum or glycerol
Based on resin, the reconciliations such as syrup, sweetener are added and suppress, are a kind of sugar for being put into chewing in mouth for people.It is general to use
Carry out fresh breath, remove the swill of dental surface, by masticatory movement, increase the secretion of saliva, there is certain cleaning mouth
The effect of chamber.But this general sugar content height of chewing gum available on the market, the excessive edible Determination of Total Body Fat that easily leads to increase
Add, and has a single function.With the increase at age, the salivary secretion in Human Physiology only has 1/10th of young man or so,
When salivary secretion is reduced, bacterium just mass propagation, therefore, the oral hygiene state of the elderly is very bad, various diseases occurs
The risk of disease is very big.Existing chewing gum can not also alleviate swelling and aching of gum, common inflammation.Clinical research shows
Oral inflammation will affect cementum, parodontium, seriously affect patient's oral health.The life that plaque is gradually deposited in dental surface
Object film is made of a large amount of bacteriums, intercellular substance, Exfoliative cells and food scraps etc.；Followed by dental calculus, bacterial plaque calcification
Becoming dental calculus afterwards, surface can often form the bacterial plaque of non-calcification, gum can be stimulated to cause inflammation, and dental calculus itself is hard coarse in addition,
Gum continued mechanical is oppressed, promotes local Nutrition and Metabolism that obstacle occurs.It deposits at the positions such as plaque, saliva and mucous membrane of mouth
In helicobacter pylori, and in the majority in plaque, and gingival sulcus and oral pocket are then a clustering areas for helicobacter pylori.Pylorus
Helicobacter is not only closely related with periodontitis, also closely related with oral keritonocytes.Helicobacter pylori is periodontitis or promotion
One of the significant bacterial of periodontitis progress.There are alkalescent saliva, swill etc. in oral cavity, is provided for the procreation of normal flora
Appropraite condition.The most common flora is alpha streptococcus and streptococcus anaerobius, followed by staphylococcus epidermis, Neisseria,
Lactobacillus, conveyor screw, Candida etc..Therefore, a kind of Multifunctional chewing gum that suitable all groups use how is produced, is become
The important topic studied now.
The object of the present invention is to provide a kind of chewing gums that can effectively improve oral environment.
The chewing gum of the invention is made of component A and component B.
The component A is the mixture of hairystalk loosestrife herb extract and Dequavet；The component B is various auxiliary materials.
Influence experiment of two kinds of substance different ratios to oral environment in component A.
1, raw medicine hairystalk loosestrife herb extract is prepared as described above, and Dequavet is commercially available.
2, experimental strain helicobacter pylori, pseudomonas aeruginosa, anginosus, Klebsiella Pneumoniae are Shandong
The Quality-control strains that province clinical examination center provides.
3, instrument and reagent nutrient agar be purchased from Hangzhou day and microorganism reagent Co., Ltd, cultured solution of broth and sterile
Normal saline dilution liquid is purchased from Zhuhai Dier Bioengineering Co., Ltd.；DL-2D1 nephelometer（Zhuhai Deere bioengineering is limited
Company）GSP-9160MBE water isolation type constant incubator（Medical Equipment Plant of Shanghai Boxun Industrial Co., Ltd.）.
4, the nutrient agar panel for preparing of culture medium is prepared by product description method.
5, bacterium solution preparation exists helicobacter pylori, pseudomonas aeruginosa, anginosus, Klebsiella Pneumoniae respectively
After activation culture of crossing on nutrient agar, the single bacterium colony for picking them separately each bacterial strain is dissolved in sterile saline, and 0.5 wheat is made
The dilution of bacteria of family name's unit, bacterial concentration is about 109cfu/ml at this time.Gained dilution of bacteria is diluted with broth bouillon
Bacteria suspension for 106cfu/ml concentration is spare.
6, minimum inhibitory concentration（MIC）Measurement use NCCLS micro-dilution method modification method.By hairystalk loosestrife herb extract
With Dequavet according to 30:1,15:1,5:1,1:1,1:5,1:15,1:30 ratio is mixed, and the medicine of 1g/ml is respectively prepared
Liquid dilutes to obtain each working solution respectively with nutrient broth.10ul is taken to be added in 96 hole micro plates respectively each working solution, every kind of work
Liquid sets 3 parallel holes.Above-mentioned spare bacteria suspension is seeded in respectively in the machined each hole for making liquid, the hole 90ul/.It will be above-mentioned spare
Bacteria suspension is set as compareing, if 3 parallel holes, the hole 100ul/.Sealing plate observes result after being placed on 35 DEG C of incubator culture 45h.
By test it is found that the ratio of hairystalk loosestrife herb extract and Dequavet is greater than 5:When 1, helicobacter pylori and pneumonia
The growth of klebsiella trace of bacteria, is greater than 30:When 1, helicobacter pylori has bacterial growth, pseudomonas aeruginosa, angina hammer
There is trace of bacteria growth in bacterium, Klebsiella Pneumoniae.When the ratio of hairystalk loosestrife herb extract and Dequavet is less than 1:When 5, verdigris
Pseudomonad insignificant growth；Less than 1:When 30, there is bacterial growth in pseudomonas aeruginosa, helicobacter pylori, anginosus,
The growth of Klebsiella Pneumoniae trace of bacteria.Therefore the weight ratio of hairystalk loosestrife herb extract and Dequavet needs to control 5:1—1:5
Between.
Chewing gum of the invention is made of raw material from the following weight：4-8 parts of Dequavet, 4-8 parts of hairystalk loosestrife herb extract,
33-39 parts of matrix, 10-16 parts of xylitol, 2-4 parts of Aspartame, 5-9 parts of D-mannital, 5-10 parts of starch, citric acid
2-4 parts, 3-7 parts of maltitol.
Preferably：6 parts of Dequavet, 6 parts of hairystalk loosestrife herb extract, 36 parts of matrix, 13 parts of xylitol, 3 parts of Aspartame,
7 parts of D-mannital, 8 parts of starch, 3 parts of citric acid, 5 parts of maltitol.
Preparation method：By first pre- thermal softening 2 hours under the conditions of 65 DEG C of matrix, moisturizing softens 1 hour at 60 DEG C.By its
He mixes raw material, will mix well in raw material after the matrix addition mixing after softening at 45 DEG C, is prepared into chewing gum material
Embryo.It is squeezed after material embryo is cooled to 15-30 DEG C of temperature, excision forming is carried out after reaching certain thickness.Finally at 20 DEG C
Under, chewing gum tablet is made in dry 4h.
Preparing for the hairystalk loosestrife herb extract is as follows：Hairystalk loosestrife herb is crushed, 10 times of 80% (volumes of amount (weight multiple) are added
Percentage) ethyl alcohol, refluxing extraction 3h filtering, the dregs of a decoction add the ethyl alcohol of 8 times of amount (weight multiple) comparable sodiums, refluxing extraction 2h
Filtering merges alcohol extract twice, ethyl alcohol is recovered under reduced pressure, and is concentrated into thick paste that relative density is 1.1 (50 DEG C of surveys) to obtain the final product.
The hairystalk loosestrife herb is annual herb, high 30-60cm；Stem is uprightly sturdy branch, four prismatics, villosity, leaf
To life；Petiole long 1.3-5cm, it is close by white fluff；The long round shape of blade is oval, and each 5-7cm of length and width, apex is blunt to round, the base portion heart
Shape or circle, edge have thin knuckle-tooth, meat, have wrinkle, two sides is by white with villus and blood red gland point.Spike is born in stem
Top and branch top, long 2.5-7.5cm, diameter 0.9-1.9cm；Calyx is by micro- pubescence, and calyx tube expands when fruit, two lip shape of limb,
Upper lip is big and wide in fruit, is in oval, lower lip section shape, has unconspicuous tooth, shrink in lip；Corolla lavender, length are calyx
2 times, two lip shape of limb, upper lip is short, and 4 split, lower lip extend, full edge, indent；Stamen 4, it is preceding to longer, filigree separation, anther ovum
Circle, Room 2；Style is long compared with stamen, and apex is split in equal 2, March at florescence.Flavour of a drug：It is sweet in flavor, it is mild-natured, it is nontoxic.Effect：Wind-dispelling,
Cough-relieving, menstruation regulating.For cold cough, tracheitis, asthma, irregular menstruation, neurasthenia.
Beneficial effects of the present invention：It yet there are no that mixture makes according to a certain percentage by hairystalk loosestrife herb extract and Dequavet
With, more have no using the two as effective active composition be applied to chewing gum report.Chewing gum of the invention can be effectively improved mouth
Chamber environment especially will improve sterilizing ability after hairystalk loosestrife herb extract and Dequavet mixture, destroy mushroom living environment, special
Shi Yongyu there be oral inflammation patient use.
Extracorporeal bacteria inhibitor test
1, experimental method：After taking chewing gum 10g of the invention to crush respectively plus 50ml hot water is made into chewing gum solution.In addition city is taken
It sells addition 50ml hot water after Dequavet 10g is crushed and is made into Dequavet solution.
2, the preparation of bacteria inhibition tablet：Sterile and dry filter paper 20 are taken, wherein 10 dropwise addition chewing gum solution 0.2ml,
Then filter paper is lain against in clean sterile plane ware, uncaps to set in incubator (37 DEG C) and dries, or set naturally dry at room temperature
It is spare after dry；Sterile dry filter paper piece 10 is taken, every dropwise addition quinoline chloramine solution 0.2ml is spare after dry.
3, streptococcus mutans are inoculated with：Dipping concentration with sterile cotton swab is that 5 × 105~5 × 106cfu/ml deforms hammer
Bacterium bacteria suspension is uniformly smeared in nutrient agar planar surface, and every to smear once, plate rotates, finally by cotton swab
Son is smeared one week around plate edge, is covered plate, is set drying at room temperature 5min.
4, bacteria inhibition tablet is placed with：4 microbiological contamination plates are set altogether, and each plate is placed with 5 bacteria inhibition tablets.With aseptic nipper coupongs
It is placed in planar surface, at a distance of 25mm or more between each print center, the periphery with plate is at a distance of 15mm or more.After being placed with,
With the light pressure-like piece of aseptic nipper, so that it is tightly attached to planar surface, cover plate, is placed in 37 DEG C of incubators and cultivates 15~20h, with trip
Mark the diameter and record of calliper to measure antibacterial ring size.
2, experimental result
The diameter of bacteria inhibition tablet antibacterial ring size containing chewing gum of the present invention is 16.6 respectively, 16.7,16.1,18.1,17.6,16.8,
17.2、18.3、16.9、17.0mm。
The diameter of bacteria inhibition tablet antibacterial ring size containing Dequavet solution is 3.26 respectively, 3.5,4.2,3.3,4.4,2.9,
2.7、3.6、3.9、3.1mm。
By testing it is found that being separately added into 50ml hot water in chewing gum situation identical with commercially available Dequavet weight
Wiring solution-forming is tested, and as a result the diameter of the bacteria inhibition tablet antibacterial ring size containing chewing gum of the present invention, which is much larger than, contains Dequavet solution
Bacteria inhibition tablet antibacterial ring size diameter, illustrate that hairystalk loosestrife herb extract in chewing gum of the present invention and Dequavet have synergistic make
With.
Experimental animal
1, cleaning grade healthy SD female rats 20, weight (202 ± 12) g are used as chronic toxicity；Cleaning grade health elder brother
Bright female small white mouse 20, weight (23 ± 2) g are used as acute toxicological experiment.It feeds with normal diet, it is common to drink water.Room temperature control
System is in (24 ± 4) DEG C, humidity (55 ± 5) %, natural lighting.
2, acute toxicological experiment selects female small white mouse 20, cleaning grade health Kunming, is randomly divided into 2 groups, test group and
Blank control group each 10.Test group is converted to the dosage of small white mouse by normal adult using the amount of chewing gum of the present invention daily,
It gavages 2 times daily.Blank control group is given clear water and is gavaged.
3, long term toxicity test cleaning grade healthy SD female rats 20.It is randomly divided into 2 groups, test group and blank control
Group each 10.Control group gives clear water, and test group is given by 30 times of stomach-fillings that adult normal usage is converted to rat dosage.Daily 2
Secondary, experimental period is 3 months.
4, acute toxicity testing result small white mouse observes mouse appearance, hair color, light without death in administration 8d after administration
Damp normal, social action, reaction are normal, ingest, drain normally.Dissection is manually put to death after 8d, observes its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination：One Yihong of hematoxylin (HE) dyeing, test group are dirty
Device surface is smooth, and institutional framework is orderly aligned, and cell size, form are normal, and endochylema, karyon dyeing are clear, with blank control group
Not statistically significant (the P of comparing difference>0.05).
5, the appearance of the rat of chronic toxicity result test group, hair color, social action, irritation etc. and to surrounding
The comparing differences such as the interest of environment, food, water are not statistically significant.Important organ row staining pathologic section is examined after rat is put to death
It looks into, HE dyeing.Rats in test groups organ tissue structure is orderly aligned, and cell size, form are normal, and endochylema, karyon dyeing are clear,
No significant difference (P compared with the control group>0.05).
Toxicity test shows that chewing gum of the invention has no toxic reaction.
There is helicobacter pyloris at positions such as plaque, saliva and mucous membrane of mouth for the means of livelihood, and with plaque
In it is in the majority, and gingival sulcus and oral pocket may be a clustering area for helicobacter pylori.Helicobacter pylori is not only close with periodontitis
Correlation, it is also closely related with oral keritonocytes.Helicobacter pylori be periodontitis or promote periodontitis occur significant bacterial it
One.Therefore, the present inventor is since in March, 2011 to being diagnosed as patients with periodontitis at one's side and give chewing gum of the invention to control
It treats.
Different degrees of chronic inflammation is presented in diagnostic criteria gum, and color is dark red or scarlet, and quality is soft, and stippling disappears,
Edge round blunt and not with facing attach；Periodontal bag formation, attachment loss, pyorrhea in bag；Loosening in various degree occurs in tooth.X line
It has been shown that, alveolar bone have different degrees of absorption.
Treatment method slowly chews chewing gum of the invention, and every bu is early, 2 times late.
Criterion of therapeutical effect is cured：Symptom completely disappears, and depth of pocket shoals or restores normal, and tooth non-loosening can be normal
Chewing.It improves：Gum mild hyperaemia, bleeding, pain, oedema mitigate.In vain：Change unobvious.
Therapeutic effect treatment carries out effect assessment after two weeks.32 are cured, is improved 9, invalid 0, total effective rate
100%。
It can be used to fresh breath using chewing gum of the invention, remove the swill of dental surface, increase saliva
Secretion promotes the exercise of facial blood circulation and muscle, and the generation of oral inflammation can also be monthly prevented and treated using 2-3 times.
Specific embodiment
Chewing gum of the invention is made of component A and component B.The component A is hairystalk loosestrife herb extract and Dequavet
Mixture；The component B is various auxiliary materials.
Embodiment one：Dequavet 4g, hairystalk loosestrife herb extract 4g, matrix 33g, xylitol 10g, Aspartame 2g, D-
Mannitol 5g, starch 5g, citric acid 2g, maltitol 3g.By first pre- thermal softening 2 hours under the conditions of 65 DEG C of matrix, in 60
Moisturizing softens 1 hour at DEG C.Other raw materials are mixed, will be filled in raw material after the matrix addition mixing after softening at 45 DEG C
Divide and mix, is prepared into chewing gum material embryo.It squeezes after material embryo is cooled to 20 DEG C of temperature, is cut after reaching certain thickness
It is cut into type.Finally at 20 DEG C, chewing gum tablet is made in dry 4h.
Embodiment two：Dequavet 6g, hairystalk loosestrife herb extract 6g, matrix 36g, xylitol 13g, Aspartame 3g, D-
Mannitol 7g, 8 g of starch, citric acid 3g, maltitol 5g, preparation method is the same as embodiment one.
Embodiment three：Dequavet 8g, hairystalk loosestrife herb extract 8g, matrix 39g, xylitol 16g, Aspartame 4g, D-
Mannitol 9g, starch 10g, citric acid 4g, maltitol 7g, preparation method is the same as embodiment one.
Claims (4)
1. a kind of chewing gum of extract containing hairystalk loosestrife herb is improving the application on oral environment, it is characterised in that hairystalk loosestrife herb extract
Improve the application on oral environment in chewing gum, chewing gum is specially made using hairystalk loosestrife herb extract, to improve oral environment,
The chewing gum is made of raw material from the following weight：4-8 parts of Dequavet, 4-8 parts of hairystalk loosestrife herb extract, matrix 33-39
Part, 10-16 parts of xylitol, 2-4 parts of Aspartame, 5-9 parts of D-mannital, 5-10 parts of starch, 2-4 parts of citric acid, malt
3-7 parts of sugar alcohol.
2. chewing gum as described in claim 1, it is characterised in that be made of raw material from the following weight：6 parts of Dequavet, row
6 parts of hay-scented extract, 36 parts of matrix, 13 parts of xylitol, 3 parts of Aspartame, 7 parts of D-mannital, 8 parts of starch, citric acid 3
Part, 5 parts of maltitol.
3. chewing gum as claimed in claim 1 or 2, it is characterised in that preparation method：Matrix is first preheated under the conditions of 65 DEG C
Softening 2 hours, moisturizing softens 1 hour at 60 DEG C, other raw materials are mixed, and mixing is added in the matrix after softening at 45 DEG C
Mixed well in raw material afterwards, be prepared into chewing gum material embryo, will material embryo be cooled to 15-30 DEG C of temperature after squeeze, when reaching
Excision forming is carried out after to certain thickness, finally at 20 DEG C, chewing gum tablet is made in dry 4h.
4. hairystalk loosestrife herb extract as claimed in claim 1 or 2, it is characterised in that preparation method：Hairystalk loosestrife herb is crushed, is added 10
Amount (weight multiple) 80% (percentage by volume) ethyl alcohol again, refluxing extraction 3h filtering, it is same that the dregs of a decoction add 8 times of amounts (weight multiple)
The ethyl alcohol of isoconcentration, refluxing extraction 2h filtering, merges alcohol extract twice, ethyl alcohol is recovered under reduced pressure, and be concentrated into relative density and be
The thick paste of 1.1 (50 DEG C of surveys) to obtain the final product.
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|---|---|---|---|
| CN201810946666.4A CN108850407A (en) | 2018-08-20 | 2018-08-20 | A kind of chewing gum of the extract containing hairystalk loosestrife herb is improving the application on oral environment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810946666.4A CN108850407A (en) | 2018-08-20 | 2018-08-20 | A kind of chewing gum of the extract containing hairystalk loosestrife herb is improving the application on oral environment |
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ID=64321118
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| CN201810946666.4A Pending CN108850407A (en) | 2018-08-20 | 2018-08-20 | A kind of chewing gum of the extract containing hairystalk loosestrife herb is improving the application on oral environment |
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| Country | Link |
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| CN (1) | CN108850407A (en) |
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2018
- 2018-08-20 CN CN201810946666.4A patent/CN108850407A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 陈少萍等主编: "《口腔临床药物手册》", 31 December 2005, 华南理工大学出版社 * |
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