CN108837105A - A kind of Chinese medicine composition and preparation method thereof for treating pudendal pruritus - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating pudendal pruritus Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, especially a kind of Chinese medicine composition and preparation method thereof for treating pudendal pruritus, the drug uses mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax, cortex dictamni, Herba Andrographitis, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress, lopseed and borneol are raw material, by reasonably arranging in pairs or groups, so that drug is with clearing heat and detoxicating, desinsection is antipruritic, anti-inflammatory analgetic, blood circulation, nourishing yin and lessening fire, the effect of inducing diuresis to remove edema, there is good therapeutic effect for pudendal pruritus caused by Different types of etiopathogenises, curative effect of medication of the present invention is significant, safety is without side-effects, later period is uneasy to recur.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, especially a kind of Chinese medicine composition for treating pudendal pruritus and its preparation side
Method.
Background technique
Pruritus of vagina is a kind of symptom caused by the various different lesions of vagina, but it is completely normal to betide vagina
Person, when itch aggravates, patient feels restless more, so that influencing life and work；Itch multidigit can also in clitoris, nymphae
Involve the skin lesions areas such as labia majora, perineum even crissum, is often paroxysmal breaking-out, labia majora, perineum even crissum etc. can also be involved
Skin lesion area；Often it is paroxysmal breaking-out, can also is duration, general night aggravation, causeless pruritus vulvue generally only occurs
In childbearing age or postmenopausal women, involve entire external genital, it is also possible to certain portion or unilateral vulva are limited only to, although scabies more
Itch extremely serious, or even be difficult to endure, but local skin and mucous membrane appearance are normal, or only because scratch excessively due to occur grab
Trace.
Summary of the invention
In order to solve the above technical problems existing in the prior art, it is treated in pudendal pruritus the present invention provides a kind of
Drug composition and preparation method thereof.
It is realized especially by following manner.
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：20~30 parts of mullein nightbrier leaf, Centipeda minima
20~30 parts, 20~30 parts of sweet wormwood, 20~30 parts of radix gentianae, 20~30 parts of edible tulip, 40~50 parts of smilax, cortex dictamni 20~
30 parts, 20~30 parts of Herba Andrographitis, 20~30 parts of Sculellaria barbata, 20~30 parts of manyleaf meadowure rhizome and root, 20~30 parts of the fruit of summer cypress, lopseed 20~30
Part, 3~5 parts of borneol.
Preferably, raw material is in parts by weight：22~26 parts of mullein nightbrier leaf, 23~27 parts of Centipeda minima, 21~25 parts of sweet wormwood,
21~25 parts of radix gentianae, 24~28 parts of edible tulip, 42~46 parts of smilax, 21~26 parts of cortex dictamni, 25~29 parts of Herba Andrographitis, half
Branch 25~29 parts of lotus, 22~26 parts of manyleaf meadowure rhizome and root, 22~26 parts of the fruit of summer cypress, 24~28 parts of lopseed, 3~4 parts of borneol.
Preferably, raw material is in parts by weight：24 parts of mullein nightbrier leaf, 24 parts of Centipeda minima, 23 parts of sweet wormwood, 23 parts of radix gentianae,
27 parts of edible tulip, 45 parts of smilax, 24 parts of cortex dictamni, 27 parts of Herba Andrographitis, 27 parts of Sculellaria barbata, 24 parts of manyleaf meadowure rhizome and root, 24 parts of the fruit of summer cypress,
26 parts of lopseed, 4 parts of borneol.
The Chinese medicine composition of above-mentioned treatment pudendal pruritus, includes the following steps：
(1) mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax and borneol are measured according to formula, after mixing
Adding water adjustment moisture content is 30~40%, is ground into fine powder, control temperature of charge is 40~60 DEG C in process of lapping；
(2) cortex dictamni, Herba Andrographitis, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress and lopseed are measured according to formula, are crushed after mixing,
200~300 meshes are crossed, using ultrasonic wave extraction 3 times, Extracting temperature is 37.5~42.5 DEG C, obtains extracting solution；
(3) step 1) fine powder and step 2) extracting solution are mixed, constant temperature processing 60 under the conditions of being placed in 100~110 DEG C
~90min, after filtering, filtrate is condensed into thick paste, and medically acceptable carrier is added, and corresponding pharmaceutical dosage form is made.
The frequency of the ultrasonic wave is 30~45kHz.
The dosage form is paste or film.
Application of the Chinese medicine composition of above-mentioned treatment pudendal pruritus in treatment private parts scabies.
Beneficial effect
Drug of the present invention uses mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax, cortex dictamni, punching
Lotus, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress, lopseed and borneol are raw material, by reasonably arranging in pairs or groups, so that drug has heat-clearing solution
Poison, the effect of desinsection is antipruritic, anti-inflammatory analgetic, blood circulation, nourishing yin and lessening fire, inducing diuresis to remove edema, for private parts caused by Different types of etiopathogenises
Itch has good therapeutic effect；Curative effect of medication of the present invention is significant, safety is without side-effects, the later period is uneasy to recur；Private parts is disturbed
Itch, vagina disturbs and itches and in utero rotten to the corn symptom, all have good curative effect.
Specific embodiment
Tuberculosis specific embodiment is limited technical solution of the present invention is further below, but claimed
Range is not only limited to made description.
Embodiment 1
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 20g, Centipeda minima 20g,
Sweet wormwood 20g, radix gentianae 20g, edible tulip 20g, smilax 40g, cortex dictamni 20g, Herba Andrographitis 20g, Sculellaria barbata 20g, manyleaf meadowure rhizome and root
20g, fruit of summer cypress 20g, lopseed 20g, borneol 3g.
Embodiment 2
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 30g, Centipeda minima 30g,
Sweet wormwood 30g, radix gentianae 30g, edible tulip 30g, smilax 50g, cortex dictamni 30g, Herba Andrographitis 30g, Sculellaria barbata 30g, manyleaf meadowure rhizome and root
30g, fruit of summer cypress 30g, lopseed 30g, borneol 5g.
Embodiment 3
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 22g, Centipeda minima 23g,
Sweet wormwood 21g, radix gentianae 21g, edible tulip 24g, smilax 42g, cortex dictamni 21g, Herba Andrographitis 25g, Sculellaria barbata 25g, manyleaf meadowure rhizome and root
22g, fruit of summer cypress 22g, lopseed 24g, borneol 3g.
Embodiment 4
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 26g, Centipeda minima 27g,
Sweet wormwood 25g, radix gentianae 25g, edible tulip 28g, smilax 46g, cortex dictamni 26g, Herba Andrographitis 29g, Sculellaria barbata 29g, manyleaf meadowure rhizome and root
26g, fruit of summer cypress 26g, lopseed 28g, borneol 4g.
Embodiment 5
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 24g, Centipeda minima 24g,
Sweet wormwood 23g, radix gentianae 23g, edible tulip 27g, smilax 45g, cortex dictamni 24g, Herba Andrographitis 27g, Sculellaria barbata 27g, manyleaf meadowure rhizome and root
24g, fruit of summer cypress 24g, lopseed 26g, borneol 4g.
The preparation method of the drug of 1~embodiment of embodiment, 5 scheme is：Each taste Chinese medicine is measured according to formula, is crushed respectively
At powder, after mixing；
Embodiment 6
A kind of Chinese medicine composition for treating pudendal pruritus, raw material are in parts by weight：Mullein nightbrier leaf 24g, Centipeda minima 24g,
Sweet wormwood 23g, radix gentianae 23g, edible tulip 27g, smilax 45g, cortex dictamni 24g, Herba Andrographitis 27g, Sculellaria barbata 27g, manyleaf meadowure rhizome and root
24g, fruit of summer cypress 24g, lopseed 26g, borneol 4g.
The Chinese medicine composition of above-mentioned treatment pudendal pruritus, includes the following steps：
(1) mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax and borneol are measured according to formula, after mixing
Adding water adjustment moisture content is 30%, is ground into fine powder, control temperature of charge is 40 DEG C in process of lapping；
(2) cortex dictamni, Herba Andrographitis, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress and lopseed are measured according to formula, are crushed after mixing,
200 meshes are crossed, using ultrasonic wave extraction 3 times, Extracting temperature is 37.5 DEG C, obtains extracting solution；
(3) step 1) fine powder and step 2) extracting solution are mixed, constant temperature handles 60min, mistake under the conditions of being placed in 100 DEG C
After filter, filtrate is condensed into thick paste, and medically acceptable carrier is added, and corresponding pharmaceutical dosage form is made.
The frequency of the ultrasonic wave is 30kHz.
The dosage form is paste.
For embodiment 7 using with 6 same materials are implemented, preparation method is as follows：
(1) mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax and borneol are measured according to formula, after mixing
Adding water adjustment moisture content is 40%, is ground into fine powder, control temperature of charge is 60 DEG C in process of lapping；
(2) cortex dictamni, Herba Andrographitis, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress and lopseed are measured according to formula, are crushed after mixing,
300 meshes are crossed, using ultrasonic wave extraction 3 times, Extracting temperature is 42.5 DEG C, obtains extracting solution；
(3) step 1) fine powder and step 2) extracting solution are mixed, constant temperature handles 90min, mistake under the conditions of being placed in 110 DEG C
After filter, filtrate is condensed into thick paste, and medically acceptable carrier is added, and corresponding pharmaceutical dosage form is made.
The frequency of the ultrasonic wave is 45kHz.
The dosage form is film.
Test example
Test selects 115 female patients to have different degrees of pruritus vulvue, and part has except some patientss because itch is excessive
And outside the scratch occurred, remaining appearance is normal；
Efficacy determination：
1. effective：Pruritis all disappears, improvement or itch subtract and (disturb breaking-out decreased duration)；
2. invalid：Pruritis is without improvement；
Recurrence rate：Above-mentioned patient is randomly divided into 6 groups, and the preparation of 1~embodiment of the embodiment of the present invention, 6 scheme is respectively adopted
Drug, daily to smear once, 7 times are as a treatment course, after 1 course for the treatment of, each group curative effect such as following table, and each group patient cures
Afterwards, investigation is looked for by schedule to last half a year, the patient of illness recurrence is counted, recurrence rate is calculated, as a result such as following table：
| Group | Number of cases | Effective number | Obvious effective rate % | Invalid number | Recur number |
| Embodiment 1 | 18 | 14 | 77.8 | 4 | 0 |
| Embodiment 2 | 19 | 14 | 73.7 | 5 | 1 |
| Embodiment 3 | 20 | 16 | 80.0 | 4 | 0 |
| Embodiment 4 | 20 | 17 | 85 | 3 | 0 |
| Embodiment 5 | 21 | 19 | 90.4 | 0 | 0 |
| Embodiment 6 | 17 | 17 | 100 | 0 | 0 |
By upper watch test result it is found that pudendal pruritus can be effectively treated using drug of the present invention, wherein with embodiment 6
The curative effect of medication of scheme preparation is best, and obvious effective rate reaches 100%.
It is important to point out that, above embodiments and test example are only limitted to do further technical solution of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical solution of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within protection category of the invention.
Claims (7)
1. a kind of Chinese medicine composition for treating pudendal pruritus, which is characterized in that raw material is in parts by weight：Mullein nightbrier leaf 20~30
Part, 20~30 parts of Centipeda minima, 20~30 parts of sweet wormwood, 20~30 parts of radix gentianae, 20~30 parts of edible tulip, smilax 40~50
Part, 20~30 parts of cortex dictamni, 20~30 parts of Herba Andrographitis, 20~30 parts of Sculellaria barbata, 20~30 parts of manyleaf meadowure rhizome and root, the fruit of summer cypress 20~30
Part, 20~30 parts of lopseed, 3~5 parts of borneol.
2. the Chinese medicine composition for the treatment of pudendal pruritus as described in claim 1, which is characterized in that the raw material is in parts by weight
For：22~26 parts of mullein nightbrier leaf, 23~27 parts of Centipeda minima, 21~25 parts of sweet wormwood, 21~25 parts of radix gentianae, edible tulip 24~28
Part, 42~46 parts of smilax, 21~26 parts of cortex dictamni, 25~29 parts of Herba Andrographitis, 25~29 parts of Sculellaria barbata, manyleaf meadowure rhizome and root 22~26
Part, 22~26 parts of the fruit of summer cypress, 24~28 parts of lopseed, 3~4 parts of borneol.
3. the Chinese medicine composition for the treatment of pudendal pruritus as claimed in claim 1 or 2, which is characterized in that the raw material is with parts by weight
It is calculated as：24 parts of mullein nightbrier leaf, 24 parts of Centipeda minima, 23 parts of sweet wormwood, 23 parts of radix gentianae, 27 parts of edible tulip, 45 parts of smilax, cortex dictamni
24 parts, 27 parts of Herba Andrographitis, 27 parts of Sculellaria barbata, 24 parts of manyleaf meadowure rhizome and root, 24 parts of the fruit of summer cypress, 26 parts of lopseed, 4 parts of borneol.
4. treating the preparation method of the Chinese medicine composition of pudendal pruritus as described in any one of claims 1 to 3, which is characterized in that
Include the following steps：
(1) mullein nightbrier leaf, Centipeda minima, sweet wormwood, radix gentianae, edible tulip, smilax and borneol are measured according to formula, water is added after mixing
Adjusting moisture content is 30~40%, is ground into fine powder, control temperature of charge is 40~60 DEG C in process of lapping；
(2) cortex dictamni, Herba Andrographitis, Sculellaria barbata, manyleaf meadowure rhizome and root, the fruit of summer cypress and lopseed are measured according to formula, is crushed after mixing, mistake
200~300 meshes, using ultrasonic wave extraction 3 times, Extracting temperature is 37.5~42.5 DEG C, obtains extracting solution；
(3) step 1) fine powder and step 2) extracting solution are mixed, under the conditions of being placed in 100~110 DEG C constant temperature processing 60~
90min, after filtering, filtrate is condensed into thick paste, and medically acceptable carrier is added, and corresponding pharmaceutical dosage form is made.
5. the preparation method of the Chinese medicine composition for the treatment of pudendal pruritus as claimed in claim 4, which is characterized in that the ultrasonic wave
Frequency be 30~45kHz.
6. the preparation method of the Chinese medicine composition for the treatment of pudendal pruritus as claimed in claim 4, which is characterized in that the dosage form is
Paste or film.
7. treating application of the Chinese medicine composition of pudendal pruritus in treatment private parts scabies as described in any one of claim 4.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112121136A (en) * | 2020-10-12 | 2020-12-25 | 官成金 | Tightening liquid for pudendum and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320451A (en) * | 2001-03-28 | 2001-11-07 | 刘杰龙 | Exterior-applied medicine for treating gynopathy |
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