CN103191340A - Drug for nursing osteochondroma - Google Patents
Drug for nursing osteochondroma Download PDFInfo
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- CN103191340A CN103191340A CN 201310107772 CN201310107772A CN103191340A CN 103191340 A CN103191340 A CN 103191340A CN 201310107772 CN201310107772 CN 201310107772 CN 201310107772 A CN201310107772 A CN 201310107772A CN 103191340 A CN103191340 A CN 103191340A
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Abstract
The invention discloses a drug for nursing osteochondroma. The drug is applied to the adjuvant therapy of osteochondroma. The drug is characterized by being prepared from the following raw pharmaceutical materials in proportioning ratio by weight: litchi chinensis Sonn., poncirus tuifoliata (L.) Raf., trachelospermum jasminoides (Lindl.) Lem., luffa cylindrica (L.) Roem., murraya jasminorage, polygonum orientale L., radix platycodi, radix puerariae, paris polyphylla Sm., aeschynomene indica L., hordeum vulgare L. and setaria italica (L.) Beauv.. Proved by clinical trials, the drug has the characteristics of good therapeutic effect and high safety in the adjuvant therapy of osteochondroma, so that the method is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to tumor medication field, be specifically related to a kind of care drug of osteochondroma.
Background technology
Osteochondroma belongs to benign bone tumour, claims again the bone wart, is apt to occur in the long bone of limbs metaphysis, and shape differs, and volume is excessive nerve compression symptom or joint function disturbance can occur.Osteochondroma is without specific process, and only at local discomfort, tumor is large and oppress surrounding tissue and produce symptom and growth and stop rear tumor and continue to increase time side and take excision.
But because osteochondroma rises from metaphysis, if do not treated, often cause the skeleton development obstacle, often cause long bone of limbs cripetura or deformity, of short and small stature.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the care drug of the osteochondroma that side effect is little.
The technical scheme that the present invention solves its technical problem is: a kind of care drug of osteochondroma is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Folium Et Cacumen Murrayae, 3 ~ 10 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Radix Platycodoniss, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 3 ~ 10 parts of Folium Aeschynomense indicaes, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Caulis Trachelospermis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 6 parts of Folium Aeschynomense indicaes, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
Wherein said:
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.But the merit promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..The nature and flavor suffering; Temperature.Return liver; Kidney channel.But merit endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.Mainly cure apoplexy, orthotonus; Joint stuffiness; facial hemiparalysis.
Fructus Polygoni Orientalis is the dry mature fruit of polygonaceae plant smartweed Polygonum orientale L..Salty, be slightly cold.Return liver, stomach warp.The merit blood eliminating mass of can faling apart, the removing food stagnancy pain relieving.
The dried roots that Radix Platycodonis is Campanulaceae Radix Platycodonis, but merit expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged.
Folium Aeschynomense indicae is the stem pith of leguminous plant Herba Aeschynonenes Indicae stem Aeschynomene indica L..Nature and flavor are bitter, flat.Attach to the lung and stomach meridians.Heat clearing away, diuresis, lactogenesis, improving eyesight.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, be slightly cold.GUIXIN, liver, kidney channel.But the merit dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.
Radix Puerariae, the root that Radix Puerariae is the leguminous plant Pachyrhizua angulatus.Sweet, hot, flat.Enter spleen, the stomach warp.Merit can be induced sweat, rash, and relaxing muscles and tendons, promote the production of body fluid, antidiarrheal.
Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship, be slightly cold.Enter Liver Channel.But the merit heat-clearing and toxic substances removing, detumescence, spasmolytic.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.But the merit dredging collateral, invigorate blood circulation, and dispels the wind.
Folium Et Cacumen Murrayae is dried leaves and the band leaf twig of rutaceae Folium Et Cacumen Murrayae Murraya exotica L. and Murraya paniculata (L.) Jack. Murraya paniculata (L.) xJack.Hot, micro-hardship, temperature.The promoting flow of QI and blood dissipating blood stasis, relieving convulsion, removing toxic substances and promoting subsidence of swelling, Eradicates wind is active.
Fructus Hordei Germinatus (parched to brown),, fry to burnt brown according to the method for frying through the drying of germinateing for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L., cools sieve dedust bits.Nature and flavor are sweet, flat.Return spleen, stomach warp.But the merit promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back newborn relieving distension.
Fructus Setariae Germinatus (parched to brown),, fry to burnt brown according to frying method through the drying of germinateing for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv..Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Composition principle: osteochondroma is a kind of benign bone tumour, at present the sick medicine without this clinically.The inventor is through the discovery of clinical research for many years, and the pathogeny of osteochondroma is " the irregular division of chondo-epiphysial cells ", and draws prescription disclosed by the invention through repetition test deliberation checking.
Compared with prior art, the present invention has following characteristics.
1, prescription uniqueness: the inventor thinks that primary disease is that expectorant folder blood stasis forms, phlegm and blood stasis, and the glue work is for suffering from, and should invigorate blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral go forward side by side, and can improve the pathology present situation of the irregular division of osteochondroma epiphysis ossification center's chondo-epiphysial cells; Avoid using the medicine of nourishing liver and kidney in side, especially avoid the product that use flesh and blood in love, it is abnormal that its reason is that such medicine can not improve skeletonization, on the contrary because " mending it not empty " causes accumulated heat in interior, promotes PD; So get Semen Litchi, Cortex Ponciri trifoliatae in side for monarch, Semen Litchi can enter the joint epiphysis, promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; Cortex Ponciri trifoliatae endogenous wind stopping relieving convulsion, eleminating phlegm and freeing channels, clinical former multiplex in apoplexy sequela, but the inventor experimental studies have found that, low dose of Cortex Ponciri trifoliatae water decoction or volatile oil all have protective effect for the chondo-epiphysial cells in cell culture; The capable loose power of described Semen Litchi is strong, and Cortex Ponciri trifoliatae is from expectorant from wind, the two cooperation, and constant breathing, reduce phlegm by endogenous wind stopping on the one hand and solve the problem of epiphysis skeletonization center island skeletonization inequality, can pass through on the other hand dredging collateral dissipating blood stasis alleviating pain, the alleviation clinical symptoms.
2, blood system medicine Caulis Trachelospermi, Retinervus Luffae Fructus, Folium Et Cacumen Murrayae, except the removing heat from blood and promoting blood circulation effect, all have the dredging collateral effect, and a medicine multiple-effect, contribute to reduce medicament categories and consumption, do not increase the Liver and kidney burden.
3, sucutaneous nodule condenses in the joint epiphysis, so the present invention writes out a prescription, with Fructus Polygoni Orientalis, Radix Platycodonis, coordinates the broken knot of Cortex Ponciri trifoliatae to reduce phlegm.
4, Radix Puerariae relaxing muscles and tendons, Rhizoma Paridis spasmolytic, Folium Et Cacumen Murrayae row are altered actively, and three medicine combineds effect are organized spasm in the hope of alleviating periarticular, reduce epiphysis periphery ligament tractive tension force, increase epiphysis stability.
5, prescription Kai Heyou road, get Folium Aeschynomense indicae department mechanism of qi and open entire in we; And the use of Fructus Hordei Germinatus (parched to brown) and Fructus Setariae Germinatus (parched to brown) is considered from reducing local excitation.
6, medicine material consumption of the present invention is groped in a large number to sum up through the inventor and is drawn, each raw material consumption is for all to have curative effect preferably in the following weight parts scope: the Semen Litchi amount is larger, the inventor studies discovery, only has escalated dose Semen Litchi side drug effect to enter the joint epiphysis; In " China book on Chinese herbal medicine ", dosage of record Cortex Ponciri trifoliatae is 15 ~ 30g, and in this prescription, Cortex Ponciri trifoliatae be low dose, and its reason is, heavy dose is apoplexy sequela, and in we, is solid protection cartilage proper splitting ossification.And the dosage of Folium Et Cacumen Murrayae is very little, reason be the Folium Et Cacumen Murrayae of middle heavy dose for narcotic analgesic, be that row alters actively and get the Folium Et Cacumen Murrayae effect in we, without heavy dose, slightly get final product.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Semen Litchi 20g, Cortex Ponciri trifoliatae 10g, Fructus Polygoni Orientalis 6g, Radix Platycodonis 10g, Folium Aeschynomense indicae 6g, Caulis Trachelospermi 10g, Radix Puerariae 10g, Rhizoma Paridis 10g, Retinervus Luffae Fructus 12g, Folium Et Cacumen Murrayae 2g, Fructus Hordei Germinatus (parched to brown) 6g, Fructus Setariae Germinatus (parched to brown) 20g.
The preparation method of embodiment 1 is: Semen Litchi, Cortex Ponciri trifoliatae, Fructus Polygoni Orientalis, Radix Platycodonis, Folium Aeschynomense indicae, Caulis Trachelospermi, Radix Puerariae, Rhizoma Paridis, Retinervus Luffae Fructus, Folium Et Cacumen Murrayae, Fructus Hordei Germinatus (parched to brown), Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of affected part hot-wet compresss sooner or later.
Embodiment 2, the crude drug weight proportion: 10 parts of Semen Litchis, 6 parts of Cortex Ponciri trifoliatae, 3 parts of Fructus Polygoni Orientaliss, 6 parts of Radix Platycodoniss, 3 parts of Folium Aeschynomense indicaes, 6 parts of Caulis Trachelospermis, 6 parts of Radix Puerariaes, 6 parts of Rhizoma Paridis, 6 parts of Retinervus Luffae Fructuss, 1 part of Folium Et Cacumen Murrayae, 3 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 3, the crude drug weight proportion: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 4, the crude drug weight proportion: 30 parts of Semen Litchis, 12 parts of Cortex Ponciri trifoliatae, 10 parts of Fructus Polygoni Orientaliss, 12 parts of Radix Platycodoniss, 10 parts of Folium Aeschynomense indicaes, 12 parts of Caulis Trachelospermis, 12 parts of Radix Puerariaes, 12 parts of Rhizoma Paridis, 12 parts of Retinervus Luffae Fructuss, 5 parts of Folium Et Cacumen Murrayae, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 25 parts of Fructus Setariae Germinatus (parched to brown).
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Puerariae, Cortex Ponciri trifoliatae, Folium Aeschynomense indicae coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) Fructus Setariae Germinatus (parched to brown), Fructus Hordei Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;
(3) Semen Litchi, Fructus Polygoni Orientalis, Radix Platycodonis, Caulis Trachelospermi, Retinervus Luffae Fructus, Rhizoma Paridis, Folium Et Cacumen Murrayae mix and add 10 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation, spray drying, draw just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained fine powder in step 2 to mix, cross 60 mesh sieves, sterilizing is standby.
During use, get appropriate mature vinegar and dress affected part.
Effective combination of said medicine, coordinate mutually, invigorates blood circulation, eliminates the phlegm, eliminating stagnation, dredging collateral, effectively reach the purpose of osteochondroma, and side effect is less.The above results is the clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: in January, 2008 ~ 2012 a year December is diagnosed as osteochondroma 90 examples, is the outpatient, is divided into matched group, hot-wet compress group and vinegar and dresses group.Matched group 30 examples, age 12 ~ 19(14.32 ± 4.71) year; Hot-wet compress group 30 examples, age 13 ~ 20(16.89 ± 6.09) year; Vinegar dresses group 30 examples, age 12 ~ 20(15.48 ± 6.11) year.Three groups of patients all have arthralgia or malaise symptoms in various degree, front comparison on sex, age, the state of an illness, the difference not statistically significant (P > 0.05), there is comparability.
1.1.2 diagnostic criteria: with reference to " osteopathia " (the 5th edition), all cases is all clarified a diagnosis according to medical history, physical examination, X-ray inspection, and cartilage oligomeric matrix albumen (COMP) detects all negative.
1.2 method.
1.2.1 Therapeutic Method: matched group is taked symptomatic treatment, exempts to bear a heavy burden, as arthralgia adopts ibuprofen oral.The hot-wet compress group on the treatment of control group scheme with gained decoction hot-wet compress in the embodiment of the present invention 1,2 times/d.Vinegar dress group on the treatment of control group scheme with gained medicated powder in the embodiment of the present invention 2, get appropriate mature vinegar and dress affected part, 2 times/d.Within 1 month, be 1 course for the treatment of, after 3 courses for the treatment of, add up curative effect.The group that dresses vinegar continues by this therapeutic scheme treatment, and be 1 year total course for the treatment of, and matched group and vinegar dress group and carries out the X-ray check after 1 year.
1.2.2 observation item: carry out symptom main suit's record, carry out respectively the X-ray check when 3m and 12m, calculate the incidence rate of long bone of limbs cripetura or deformity.Definite method of long bone of limbs cripetura is comply with " osteopathia ", by a year growth ratio, contrasts this age bracket balanced growth ratio, as in extremity any one side year growth ratio be judged as and the long bone cripetura occurs lower than 10% of balanced growth ratio.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, the enumeration data chi-square criterion.
2 results.
2.1 respectively organize performance: after 3 courses for the treatment of, what the hot-wet compress group finally completed whole-course treatment is 22 examples, completion rate 73.33%, and the case that comes off all can not adhere to due to complex operation using.Vinegar dresses group completion rate 100%.
2.2 before and after treatment, X-ray checks relatively (after treating 3 months): matched group 36.67% patient occurs that the tumor body becomes large, and the hot-wet compress group is 13.64%, and it is 16.67% that vinegar dresses group.The bad progress incidence rate that vinegar dresses group and hot-wet compress group is starkly lower than matched group (P<0.05).Illustrate that the present invention can control PD.
2.3 before and after treatment, X-ray checks relatively (after treating 1 year): matched group 53.33% patient occurs that the tumor body becomes large or quantity and increases, and vinegar to dress group be 20.00%, vinegar dresses group and is starkly lower than matched group (P<0.05).Long bone of limbs cripetura or deformity appear in matched group 36.67% patient, and vinegar to dress group be 13.33%, the incidence rate that vinegar dresses group long bone of limbs cripetura or deformity is starkly lower than matched group (P<0.05).
2.4 adverse reaction rate relatively: vinegar dresses group and the hot-wet compress group has no obvious adverse reaction.
3. conclusion.
This result of study shows, takes hot-wet compress group of the present invention and vinegar and dresses the group obvious effective rate apparently higher than matched group, and can prevent that the osteochondroma state of an illness from further developing.Long-term taking medicine, contribute to reduce the incidence rate of long bone of limbs cripetura or deformity.
Claims (2)
1. the care drug of an osteochondroma, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Folium Et Cacumen Murrayae, 3 ~ 10 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Radix Platycodoniss, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 3 ~ 10 parts of Folium Aeschynomense indicaes, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
2. the care drug of a kind of osteochondroma according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Semen Litchis, 10 parts of Cortex Ponciri trifoliatae, 10 parts of Caulis Trachelospermis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Folium Et Cacumen Murrayae, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 6 parts of Folium Aeschynomense indicaes, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310107772 CN103191340A (en) | 2013-03-31 | 2013-03-31 | Drug for nursing osteochondroma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201310107772 CN103191340A (en) | 2013-03-31 | 2013-03-31 | Drug for nursing osteochondroma |
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| Publication Number | Publication Date |
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| CN103191340A true CN103191340A (en) | 2013-07-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201310107772 Withdrawn CN103191340A (en) | 2013-03-31 | 2013-03-31 | Drug for nursing osteochondroma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908511A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine pill for treating chondroma and preparation method thereof |
-
2013
- 2013-03-31 CN CN 201310107772 patent/CN103191340A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908511A (en) * | 2014-04-03 | 2014-07-09 | 荆振海 | Traditional Chinese medicine pill for treating chondroma and preparation method thereof |
| CN103908511B (en) * | 2014-04-03 | 2016-04-27 | 荆振海 | One treats chondromatous Chinese medicinal pill and preparation method |
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Application publication date: 20130710 |