CN103191345A - Postoperative drug for chronic peptic ulcer and esophagitis syndrome - Google Patents
Postoperative drug for chronic peptic ulcer and esophagitis syndrome Download PDFInfo
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Abstract
The invention discloses a postoperative drug for chronic peptic ulcer and esophagitis syndrome. The drug is applied to the postoperative treatment of chronic peptic ulcer and esophagitis syndrome. The drug is characterized by being prepared from the following raw pharmaceutical materials in proportioning ratio by weight: litchi chinensis Sonn., lindernia ruellioides (Colsm.)Pennell, polygonum orientale L., radix platycodi, aeschynomene indica L., trachelospermum jasminoides (Lindl.) Lem., radix puerariae, paris polyphylla Sm., luffa cylindrica (L.) Roem., manis pentadactyla Linnaeus, hordeum vulgare L. and setaria italica (L.) Beauv.. Proved by clinical trials, the drug has the characteristics of low recurrence rate and high safety in the postoperative treatment of chronic peptic ulcer and esophagitis syndrome, so that the method is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of chronic peptic ulcer and the medication of esophagitis syndrome postoperative.
Background technology
Chronic peptic ulcer and esophagitis syndrome refer to that the lower esophageal mucosa is replaced by the stomach columnar epithelium.Intrinsic can be congenital, but often is secondary to reflux esophagitis, on the basis of stomach-esophageal reflux esophagitis and ulcer takes place.Its pathological characteristic is that acid nonfast squamous epithelial cancer is damaged, and acidproof columnar epithelium regeneration is also involved distal esophagus to vertical spread gradually.The penetrable esophageal wall of ulcer makes mediastinum tissue's fibrosis and lymphadenitis takes place, and causes bleeding if blood vessel is damaged, and mediastinum and pleura can have purulent lesion.Microscopy mucosa internal layer has the columnar epithelial cell unusual and hypertrophy of atypia.
And present Therapeutic Method comprises two kinds of medical treatment and surgical interventions.The medicine that chronic peptic ulcer and esophagitis syndrome medical treatment use comprises uses the mucosa protective agent sucralfate, gives H2-receptor blocking agent or proton pump inhibitor and dynamics-promoting medicine prepulsid simultaneously.But in fact clinical effectiveness is also not obvious.Many final rely on surgical operation therapies, but behind the operative treatment, the some cases stomach columnar epithelium lined esophagus pathology course of dividing a word with a hyphen at the end of a line can not stop, and causes relapse rate than higher.So present clinical shortage is a kind of for chronic peptic ulcer and esophagitis syndrome therapeutic endoscopy postoperative, and the surgical operation therapy postoperative is used for improving the mucomembranous cell paraplasm, and reduces the medicine of relapse rate.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, and a kind of chronic peptic ulcer and the medication of esophagitis syndrome postoperative are provided, and is used for improving the mucomembranous cell paraplasm, reduces the postoperative recurrence rate.
The technical scheme that the present invention solves its technical problem is: a kind of chronic peptic ulcer and the medication of esophagitis syndrome postoperative is characterized in that being prepared from by following materials of weight proportions medicine: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Lindernia ruellioides (Colsm.) Pennell, 3 ~ 10 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Radix Platycodoniss, 3 ~ 10 parts of Folium Aeschynomense indicaes, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Squama Manis, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
Chinese medicine of the present invention is prepared from by following optimum weight part proportion raw material: 20 parts of Semen Litchis, 10 parts of Lindernia ruellioides (Colsm.) Pennell, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Squama Maniss, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
Wherein said:
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Sweet, the little hardship of nature and flavor, temperature.Return liver, kidney channel.But the merit promoting QI to circulate and dispersing the agglomeration of the pathogens, the cold relieving pain relieving.
Lindernia ruellioides (Colsm.) Pennell is for Scrophulariaceae Vandellia plant Lindernia ruellioides (Colsm.) Pennell Lindernia ruellioides (Colsm.) Pennell, with all herbal medicine.Nature and flavor are sweet, light, and are flat.But the merit vital energy regualting and blood circulation-promoting, reducing swelling and alleviating pain.
Fructus Polygoni Orientalis is the dry mature fruit of polygonaceae plant smartweed Polygonum orientale L..Salty, be slightly cold.Return liver, stomach warp.The merit blood eliminating mass of can loosing, the removing food stagnancy pain relieving.
Radix Platycodonis is the dried roots of campanulaceae Platycodon grandiflouorum, but the merit expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged.
Folium Aeschynomense indicae is the stem pith of leguminous plant Herba Aeschynonenes Indicae stem Aeschynomene indica L..Nature and flavor hardship, flat.Attach to the lung and stomach meridians.Heat clearing away, diuresis, lactogenesis makes eye bright.
Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship is slightly cold.GUIXIN, liver, kidney channel.But the merit dispelling wind and removing obstruction in the collateral, the removing heat from blood detumescence.
Radix Puerariae, Radix Puerariae are the root of leguminous plant Pachyrhizua angulatus.Sweet, hot, flat.Go into spleen, the stomach warp.Merit can be induced sweat, rash, and Shujin promotes the production of body fluid, antidiarrheal.
Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship is slightly cold.Go into Liver Channel.But the merit heat-clearing and toxic substances removing, detumescence, spasmolytic.
Retinervus Luffae Fructus is the vascular bundle of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Sweet, flat.Return lung, stomach, Liver Channel.But the merit collateral dredging is invigorated blood circulation, and dispels the wind.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Fructus Hordei Germinatus (parched to brown), for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. through the drying of germinateing, fry to burnt brown according to the method for frying, cool sieve dedust bits.Nature and flavor are sweet, and are flat.Return spleen, stomach warp.But the merit promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.
Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. through the drying of germinateing, fry to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.
Composition principle: chronic peptic ulcer and esophagitis syndrome refer to that the lower esophageal mucosa is replaced by the stomach columnar epithelium.Operative treatment can improve digestive tract power, solves symptoms such as gastralgia belch, but can not fundamentally solve " the stomach columnar epithelium lined esophagus is divided a word with a hyphen at the end of a line " this pathological factor, postoperative recurrence rate height.The traditional Chinese medical science is how identical with reflux esophagitis for the treatment of this disease at present, how to start with from hyperactive liver-QI attacking the stomach, syndrome of liver-stomach heat, deficiency of YIN of the spleen and stomach, but demonstrate,proves not to disease, and curative effect is relatively poor, can not reduce the postoperative recurrence rate.
Compared with prior art, the present invention has following characteristics.
1, prescription uniqueness: the inventor thinks that primary disease is that expectorant folder blood stasis forms, and phlegm and blood stasis, glue work be for suffering from, and should invigorate blood circulation, eliminates the phlegm, eliminating stagnation, collateral dredging go forward side by side, and can improve the paraplasm pathology present situation of chronic peptic ulcer and esophagitis syndrome mucosa; Avoid using the medicine of liver heat removing circulation of qi promoting such as Radix Bupleuri, Radix Curcumae, Radix Gentianae in the side, its reason is that such medicine can not improve the mucosa paraplasm, on the contrary easy cold and cool catharsis impairment of YANG impairment of YIN too; Get Semen Litchi, Lindernia ruellioides (Colsm.) Pennell in the side and be monarch, Semen Litchi can be gone into gastral cavilty, promoting QI to circulate and dispersing the agglomeration of the pathogens, cold relieving pain relieving; Record Lindernia ruellioides (Colsm.) Pennell in " China's book on Chinese herbal medicine ": " vital energy regualting and blood circulation-promoting, removing toxic substances and promoting subsidence of swelling; Main menoxenia; Dysmenorrhea; Amenorrhea; Stomachache; Acute mastitis; Scrofula; Traumatic injury; The Serpentis lyssodexis." dosage range is 15-30g, but inventor's clinical experience finds that the composition in its volatile oil can be protected acid nonfast squamous cell, prevents that the regeneration of stomach columnar epithelium from dividing a word with a hyphen at the end of a line; Cooperate the Semen Litchi temperature logical, a cold heat is passed through by temperature on the one hand and is loose to improve digestive tract power, solves symptoms such as gastralgia belch, can protect esophagus hypomere mucosa by Lindernia ruellioides (Colsm.) Pennell on the other hand; Semen Litchi can increase the curative effect of Lindernia ruellioides (Colsm.) Pennell this respect.
2, blood system medicine Caulis Trachelospermi, Retinervus Luffae Fructus all have the collateral dredging effect except the removing heat from blood and promoting blood circulation effect, and a medicine multiple-effect helps to reduce medicament categories and consumption, do not increase postoperative patient Liver and kidney burden.
3, sucutaneous nodule condenses in gastral cavilty, cooperates the broken knot of Semen Litchi to reduce phlegm so the present invention writes out a prescription with Fructus Polygoni Orientalis, Radix Platycodonis.
4, Radix Puerariae Shujin, Rhizoma Paridis spasmolytic, Squama Manis are capable scurries actively, and three medicine combineds effect help to alleviate esophageal regurgitation in the hope of alleviating esophagus hypomere smooth muscle dystonia.
5, prescription is considered from the postoperative patient medication, and opening entirely has, and gets the Folium Aeschynomense indicae mechanism of qi among the we and opens entirely, and does not have the anxiety of the moon of feeling frustrated; And the use of Fructus Hordei Germinatus (parched to brown) and Fructus Setariae Germinatus (parched to brown) also is to consider from interior tonifying the spleen gas; Simultaneously we avoid the medicine that uses soothing the liver row to loose, loose too because postoperative is capable, then consume impairment of QI the moon.
6, medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, each raw material consumption is for all to have curative effect preferably in the following weight parts scope: the Semen Litchi amount is bigger, the inventor discovers to have only escalated dose Semen Litchi side drug effect to go into gastral cavilty; And the dosage of Squama Manis is very little, and reason is that the Squama Manis of middle heavy dose is dry excessively, is that auxiliary Semen Litchi temperature is logical and get the Squama Manis effect among the we, need not heavy dose, gets final product slightly.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Semen Litchi 20g, Lindernia ruellioides (Colsm.) Pennell 10g, Fructus Polygoni Orientalis 6g, Radix Platycodonis 10g, Folium Aeschynomense indicae 6g, Caulis Trachelospermi 10g, Radix Puerariae 10g, Rhizoma Paridis 10g, Retinervus Luffae Fructus 12g, Squama Manis 2g, Fructus Hordei Germinatus (parched to brown) 6g, Fructus Setariae Germinatus (parched to brown) 20g.
The preparation method of embodiment 1 is: Semen Litchi, Lindernia ruellioides (Colsm.) Pennell, Fructus Polygoni Orientalis, Radix Platycodonis, Folium Aeschynomense indicae, Caulis Trachelospermi, Radix Puerariae, Rhizoma Paridis, Retinervus Luffae Fructus, Squama Manis, Fructus Hordei Germinatus (parched to brown), Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, get filtrate after 30 minutes, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.
Embodiment 2, the crude drug weight proportion: 10 parts of Semen Litchis, 6 parts of Lindernia ruellioides (Colsm.) Pennell, 3 parts of Fructus Polygoni Orientaliss, 6 parts of Radix Platycodoniss, 3 parts of Folium Aeschynomense indicaes, 6 parts of Caulis Trachelospermis, 6 parts of Radix Puerariaes, 6 parts of Rhizoma Paridis, 6 parts of Retinervus Luffae Fructuss, 1 part of Squama Manis, 3 parts of Fructus Hordei Germinatus (parched to brown)s, 10 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 3, the crude drug weight proportion: 20 parts of Semen Litchis, 10 parts of Lindernia ruellioides (Colsm.) Pennell, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Squama Maniss, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
Embodiment 4, the crude drug weight proportion: 30 parts of Semen Litchis, 12 parts of Lindernia ruellioides (Colsm.) Pennell, 10 parts of Fructus Polygoni Orientaliss, 12 parts of Radix Platycodoniss, 10 parts of Folium Aeschynomense indicaes, 12 parts of Caulis Trachelospermis, 12 parts of Radix Puerariaes, 12 parts of Rhizoma Paridis, 12 parts of Retinervus Luffae Fructuss, 5 parts of Squama Maniss, 10 parts of Fructus Hordei Germinatus (parched to brown)s, 25 parts of Fructus Setariae Germinatus (parched to brown).
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Radix Puerariae, Lindernia ruellioides (Colsm.) Pennell, Folium Aeschynomense indicae coarse powder are extracted volatile oil with vapor distillation respectively, and collect the back mixing for standby use;
(2) Fructus Setariae Germinatus (parched to brown), Fructus Hordei Germinatus (parched to brown) are pulverized 150 mesh sieves, and became fine powder standby;
(3) Semen Litchi, Fructus Polygoni Orientalis, Radix Platycodonis, Caulis Trachelospermi, Retinervus Luffae Fructus, Rhizoma Paridis, Squama Manis mixing add 10 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction left standstill; Add 95% ethanol of 3 ~ 4 times of medicinal liquids then in the decocting liquid, left standstill 15 minutes, with 3000rpm/min centrifugal 20 minutes then, get precipitation, spray drying draws material just;
(4) gained volatile oil in the step 1 is sprayed in the first material of step 3 gained, add gained fine powder mixing in the step 2, cross 60 mesh sieves, encapsulated forming.
Can set every capsules is 0.5g.
Effective combination of said medicine is coordinated mutually, invigorates blood circulation, eliminates the phlegm, eliminating stagnation, collateral dredging, effectively reach the purpose that reduces chronic peptic ulcer and esophagitis syndrome postoperative recurrence rate, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case is selected: in March, 2008 ~ 2012 a year December is diagnosed as chronic peptic ulcer and the parallel surgical operation therapy of esophagitis syndrome 90 examples, is divided into matched group, decoction group and Capsules group at random, every group of each 30 example.Compare in sex, age, the state of an illness, art formula before three groups of patient treatments, and the difference not statistically significant (P〉0.05), have comparability.
1.1.2 diagnostic criteria: with reference to " surgery " (the 5th edition), all case is all clarified a diagnosis according to medical history, physical examination, X-ray inspection, pathologic finding.
1.2 method
1.2.1 Therapeutic Method: postoperative began to treat on the 7th day.Matched group is taked symptomatic treatment.The decoction group is with gained decoction oral in the embodiment of the invention 1,2 times/d.Capsules group is with gained capsule oral in the embodiment of the invention 3,2g/ time, 2 times/d.1 month was 1 course for the treatment of.
1.2.2 observation index: observe and calculate esophageal regurgitation incidence rate, relapse rate in 1 year.
1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, the enumeration data chi-square criterion.
2 results.
2.1 esophageal regurgitation incidence rate: the matched group incidence rate is 33.33%; Decoction group incidence rate is 13,33%; The Capsules group incidence rate is 10.00%.The esophageal regurgitation incidence rate of Capsules group and decoction group is starkly lower than matched group (P＜0.05).
2.2 relapse rate in 1 year: the matched group incidence rate is 20.00%; Decoction group incidence rate is 6,67%; The Capsules group incidence rate is 10.00%.Relapse rate is starkly lower than matched group (P＜0.05) in decoction group and the Capsules group 1 year.
2.3 adverse reaction rate relatively: obvious adverse reaction does not all appear in matched group, Capsules group and decoction group.
3. conclusion.
This result of study shows, take decoction group of the present invention and Capsules group esophageal regurgitation incidence rate and in 1 year relapse rate be starkly lower than matched group, illustrate that the present invention has that long-term prognosis is good, the safety advantage of higher being used for chronic peptic ulcer and esophagitis syndrome postoperative.
Claims (2)
1. a chronic peptic ulcer and the medication of esophagitis syndrome postoperative is characterized in that being prepared from by following materials of weight proportions medicine: 10 ~ 30 parts of Semen Litchis, 6 ~ 12 parts of Lindernia ruellioides (Colsm.) Pennell, 3 ~ 10 parts of Fructus Polygoni Orientaliss, 6 ~ 12 parts of Radix Platycodoniss, 3 ~ 10 parts of Folium Aeschynomense indicaes, 6 ~ 12 parts of Caulis Trachelospermis, 6 ~ 12 parts of Radix Puerariaes, 6 ~ 12 parts of Rhizoma Paridis, 6 ~ 12 parts of Retinervus Luffae Fructuss, 1 ~ 5 part of Squama Manis, 3 ~ 10 parts of Fructus Hordei Germinatus (parched to brown)s, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).
2. a kind of chronic peptic ulcer according to claim 1 and the medication of esophagitis syndrome postoperative is characterized in that being prepared from by following materials of weight proportions medicine: 20 parts of Semen Litchis, 10 parts of Lindernia ruellioides (Colsm.) Pennell, 6 parts of Fructus Polygoni Orientaliss, 10 parts of Radix Platycodoniss, 6 parts of Folium Aeschynomense indicaes, 10 parts of Caulis Trachelospermis, 10 parts of Radix Puerariaes, 10 parts of Rhizoma Paridis, 10 parts of Retinervus Luffae Fructuss, 2 parts of Squama Maniss, 6 parts of Fructus Hordei Germinatus (parched to brown)s, 20 parts of Fructus Setariae Germinatus (parched to brown).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110339272A (en) * | 2019-08-28 | 2019-10-18 | 河南民生智能医疗技术股份有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating coronary heart disease PCI combined postoperative peptic ulcer |
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Non-Patent Citations (1)
| Title |
|---|
| 徐飞 等: "中医药治疗反流食管炎研究进展", 《重庆市中医药学会学术年会论文集》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339272A (en) * | 2019-08-28 | 2019-10-18 | 河南民生智能医疗技术股份有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating coronary heart disease PCI combined postoperative peptic ulcer |
| CN110339272B (en) * | 2019-08-28 | 2021-09-10 | 河南民生智能医疗技术股份有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and peptic ulcer after PCI (percutaneous coronary intervention) operation and preparation method thereof |
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