CN108815567A - A kind of preparation method of antiseptic dressing aquagel - Google Patents
A kind of preparation method of antiseptic dressing aquagel Download PDFInfo
- Publication number
- CN108815567A CN108815567A CN201810566933.5A CN201810566933A CN108815567A CN 108815567 A CN108815567 A CN 108815567A CN 201810566933 A CN201810566933 A CN 201810566933A CN 108815567 A CN108815567 A CN 108815567A
- Authority
- CN
- China
- Prior art keywords
- aquagel
- solution
- preparation
- chitosan
- antiseptic dressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
Abstract
The invention discloses a kind of preparation methods of antiseptic dressing aquagel, specifically include following steps：Chitosan is dissolved in obtained solution A in acetum first, Tween 80 is dissolved in obtained solution B in petroleum ether, solution A is added drop-wise in solution B and is stirred, and glutaraldehyde solution is added dropwise, chitosan porous microsphere is made；Then surface being carried out to chitosan porous microsphere using dopamine hydrochloride to be modified, being then modified using acrylic ester monomer, aquagel is made.This method is easy to operate, and aquagel stability obtained is good, and anti-microbial property is excellent.
Description
Technical field：
The present invention relates to field of medical materials, are specifically related to a kind of preparation side of antiseptic dressing aquagel
Method.
Background technique：
A kind of net high-polymer swelling body containing large quantity of moisture that aerogel dressing is made of water-insoluble polymer,
With good water imbibition, when contacting aquation repeatedly can occur for hydrogel and the surface of a wound, have and provide moisture to the surface of a wound and inhale
The dual function for receiving sepage is a kind of current clinically used Medical dressing.
Traditional aerogel dressing has absorbable wound fluid, keeps the surface of a wound wet, reduces scar and is formed, promotes wound
It the advantages that mouth healing, has been to be concerned by more and more people.Especially suitable for the protecting wound surfaces such as wound, scald, burn and treatment.This
A little aerogel dressing products are generally thicker, and antibacterial effect is less desirable, and stability is poor.
Summary of the invention：
The object of the present invention is to provide a kind of preparation method of antiseptic dressing aquagel, this method operation letters
Single, aquagel stability obtained is good, and anti-microbial property is excellent.
To achieve the above object, the present invention uses following technical scheme：
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in acetum, obtained solution A, Tween 80 is dissolved in obtained solution B in petroleum ether；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
Glutaraldehyde solution is added dropwise into lotion and stirs 3-6h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1-2h, after reaction plus
Enter acrylic ester monomer, initiator is to slowly warm up to 60-70 DEG C of reaction 30-50min, is cooled to room temperature after reaction, room
Temperature is placed 3-4 days, and aquagel is made.
As a preferred embodiment of the above technical solution, in step (1), the mass concentration of the acetum is 15-20%.
As a preferred embodiment of the above technical solution, in step (1), the mass ratio of chitosan and acetum is 1：(20-30).
As a preferred embodiment of the above technical solution, Tween 80 in step (1), petroleum ether volume ratio be 1：(20-40).
As a preferred embodiment of the above technical solution, in step (1), chitosan, Tween 80 mass ratio be 1：(0.013-
0.015)。
As a preferred embodiment of the above technical solution, in step (2), the mass concentration of the glutaraldehyde solution is 5%, and molten
The volume ratio of liquid A is 3：(10-20).
As a preferred embodiment of the above technical solution, in step (3), the chitosan porous microsphere, dopamine hydrochloride, three hydroxyls
Aminomethane, acrylic ester monomer mass ratio be 5：(0.2-0.6)：0.01：(1-2).
As a preferred embodiment of the above technical solution, in step (3), the acrylic ester monomer is acrylic acid, metering system
One of acid, ethyl acrylate or a variety of mixing.
As a preferred embodiment of the above technical solution, the dosage of the initiator is the 1%-3% of acrylic ester monomer quality.
The invention has the advantages that：
The method comprises the steps of firstly, preparing chitosan microballs, good dispersion, have certain anti-microbial property, and have the effect of hemostasis
Fruit, in order to improve its mechanical property, poly-dopamine is modified its surface by the present invention first, so that poly-dopamine is grafted on
The surface of chitosan microball effectively improves its mechanical property under the premise of not influencing chitosan anti-bacteria performance, in order into one
Step improves the water absorbing properties of hydrogel material, and the present invention is further modified it using acrylic ester monomer, water-setting obtained
Glue stability is good, and anti-microbial property is excellent.
Specific embodiment：
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 15%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：20：0.013；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 3h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1h, be added after reaction
Acrylic ester monomer, initiator are to slowly warm up to 60-70 DEG C of reaction 30min, are cooled to room temperature after reaction, room temperature is put
It sets 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane, third
The mass ratio of olefin(e) acid esters monomer is 5：0.2：0.01：1.
Embodiment 2
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 20%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：30：0.015；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 6h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 2h, be added after reaction
Acrylic ester monomer, initiator are to slowly warm up to 60-70 DEG C of reaction 50min, are cooled to room temperature after reaction, room temperature is put
It sets 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane, third
The mass ratio of olefin(e) acid esters monomer is 5：0.6：0.01：2.
Embodiment 3
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 16%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：22：0.0135；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 3.5h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1.2h, after reaction plus
Enter acrylic ester monomer, initiator is to slowly warm up to 60-70 DEG C of reaction 35min, is cooled to room temperature after reaction, room temperature
It places 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane,
The mass ratio of acrylic ester monomer is 5：0.3：0.01：1.2.
Embodiment 4
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 17%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：24：0.014；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 4h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1.4h, after reaction plus
Enter acrylic ester monomer, initiator is to slowly warm up to 60-70 DEG C of reaction 40min, is cooled to room temperature after reaction, room temperature
It places 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane,
The mass ratio of acrylic ester monomer is 5：0.4：0.01：1.4.
Embodiment 5
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 18%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：26：0.014；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 4.5h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1.6h, after reaction plus
Enter acrylic ester monomer, initiator is to slowly warm up to 60-70 DEG C of reaction 40min, is cooled to room temperature after reaction, room temperature
It places 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane,
The mass ratio of acrylic ester monomer is 5：0.5：0.01：1.6.
Embodiment 6
A kind of preparation method of antiseptic dressing aquagel, includes the following steps：
(1) chitosan is dissolved in the acetum that mass concentration is 18%, Tween 80 is dissolved in petroleum by obtained solution A
Obtained solution B in ether；Wherein, the mass ratio of chitosan and acetum, Tween 80 is 1：28：0.0145；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made,
The glutaraldehyde solution that mass concentration is 5% is added dropwise into lotion and stirs 5.5h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, is then added more
Bar amine hydrochlorate, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1.8h, after reaction plus
Enter acrylic ester monomer, initiator is to slowly warm up to 60-70 DEG C of reaction 45min, is cooled to room temperature after reaction, room temperature
It places 3-4 days, aquagel is made；Wherein, chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane,
The mass ratio of acrylic ester monomer is 5：0.5：0.01：1.8.
Anti-bacterial hydrogel stability produced by the present invention is good, is up to the bacteriostasis rate of Escherichia coli and staphylococcus aureus
98.9% or more.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of preparation method of antiseptic dressing aquagel, which is characterized in that include the following steps：
(1) chitosan is dissolved in acetum, obtained solution A, Tween 80 is dissolved in obtained solution B in petroleum ether；
(2) solution A is added drop-wise in solution B, continues to stir 30min after agitation and dropping when being added dropwise, lotion is made, to cream
Glutaraldehyde solution is added dropwise in liquid and stirs 3-6h, filters, it is dry, chitosan porous microsphere is made；
(3) chitosan porous microsphere obtained above is dispersed in deionized water and is dispersed with stirring uniformly, dopamine is then added
Hydrochloride, trishydroxymethylaminomethane are added dropwise ammonium hydroxide and adjust pH value of solution to 8-9, be stirred to react 1-2h, third is added after reaction
Olefin(e) acid esters monomer, initiator are to slowly warm up to 60-70 DEG C of reaction 30-50min, are cooled to room temperature after reaction, room temperature is put
It sets 3-4 days, aquagel is made.
2. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(1) in, the mass concentration of the acetum is 15-20%.
3. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(1) in, the mass ratio of chitosan and acetum is 1：(20-30).
4. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(1) Tween 80 in, petroleum ether volume ratio be 1：(20-40).
5. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(1) in, chitosan, Tween 80 mass ratio be 1：(0.013-0.015).
6. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(2) in, the mass concentration of the glutaraldehyde solution is 5%, and the volume ratio with solution A is 3：(10-20).
7. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(3) in, the chitosan porous microsphere, dopamine hydrochloride, trishydroxymethylaminomethane, acrylic ester monomer mass ratio
It is 5：(0.2-0.6)：0.01：(1-2).
8. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：Step
(3) in, the acrylic ester monomer is one of acrylic acid, methacrylic acid, ethyl acrylate or a variety of mixing.
9. a kind of preparation method of antiseptic dressing aquagel as described in claim 1, it is characterised in that：It is described to draw
The dosage for sending out agent is the 1%-3% of acrylic ester monomer quality.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810566933.5A CN108815567A (en) | 2018-06-05 | 2018-06-05 | A kind of preparation method of antiseptic dressing aquagel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810566933.5A CN108815567A (en) | 2018-06-05 | 2018-06-05 | A kind of preparation method of antiseptic dressing aquagel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108815567A true CN108815567A (en) | 2018-11-16 |
Family
ID=64143711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810566933.5A Withdrawn CN108815567A (en) | 2018-06-05 | 2018-06-05 | A kind of preparation method of antiseptic dressing aquagel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108815567A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260509A (en) * | 2018-11-27 | 2019-01-25 | 浙江海洋大学 | A kind of self assembly contact-type anti-bacterial hydrogel dressing and preparation method thereof based on poly-dopamine and chitosan oligosaccharide |
| CN110237782A (en) * | 2019-06-26 | 2019-09-17 | 中南民族大学 | A kind of preparation method of high-strength, antioxidant chitosan/poly-dopamine composite hydrogel |
| CN111909555A (en) * | 2020-08-27 | 2020-11-10 | 东来涂料技术（上海）股份有限公司 | UV (ultraviolet) antibacterial coating and preparation method thereof |
| CN112300418A (en) * | 2020-09-24 | 2021-02-02 | 山东百多安医疗器械股份有限公司 | Adhesive high-efficiency hemostatic microsphere and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101885906A (en) * | 2010-07-17 | 2010-11-17 | 厦门大学 | Degradable biological hydrogel and preparation method thereof |
| CN102675651B (en) * | 2012-04-20 | 2014-06-04 | 常州华联保健敷料有限公司 | Preparation method of chitosan hydrogel for antiseptic dressing |
| CN103920180A (en) * | 2014-03-13 | 2014-07-16 | 上海应用技术学院 | Chitosan hydrogel for antibacterial dressing and preparation method thereof |
| CN107737370A (en) * | 2017-11-20 | 2018-02-27 | 西南交通大学 | It is a kind of to be used for the high-strength of repair of cartilage, superlastic, the preparation method of conductive hydrogel |
-
2018
- 2018-06-05 CN CN201810566933.5A patent/CN108815567A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101885906A (en) * | 2010-07-17 | 2010-11-17 | 厦门大学 | Degradable biological hydrogel and preparation method thereof |
| CN102675651B (en) * | 2012-04-20 | 2014-06-04 | 常州华联保健敷料有限公司 | Preparation method of chitosan hydrogel for antiseptic dressing |
| CN103920180A (en) * | 2014-03-13 | 2014-07-16 | 上海应用技术学院 | Chitosan hydrogel for antibacterial dressing and preparation method thereof |
| CN107737370A (en) * | 2017-11-20 | 2018-02-27 | 西南交通大学 | It is a kind of to be used for the high-strength of repair of cartilage, superlastic, the preparation method of conductive hydrogel |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109260509A (en) * | 2018-11-27 | 2019-01-25 | 浙江海洋大学 | A kind of self assembly contact-type anti-bacterial hydrogel dressing and preparation method thereof based on poly-dopamine and chitosan oligosaccharide |
| CN110237782A (en) * | 2019-06-26 | 2019-09-17 | 中南民族大学 | A kind of preparation method of high-strength, antioxidant chitosan/poly-dopamine composite hydrogel |
| CN110237782B (en) * | 2019-06-26 | 2021-10-22 | 中南民族大学 | Preparation method of high-strength antioxidant chitosan/polydopamine composite hydrogel |
| CN111909555A (en) * | 2020-08-27 | 2020-11-10 | 东来涂料技术（上海）股份有限公司 | UV (ultraviolet) antibacterial coating and preparation method thereof |
| CN112300418A (en) * | 2020-09-24 | 2021-02-02 | 山东百多安医疗器械股份有限公司 | Adhesive high-efficiency hemostatic microsphere and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108815567A (en) | A kind of preparation method of antiseptic dressing aquagel | |
| CN110694102A (en) | 3D printing hydrogel wound dressing with long-acting antibacterial effect | |
| GB2537010B (en) | Composition for a wound dressing | |
| CN103920180B (en) | A kind of antiseptic dressing aquagel and preparation method thereof | |
| CN110448722A (en) | A kind of injectable is containing the temperature sensitive composite antibacterial hydrogel material of tannic acid and its preparation and application | |
| CN110755678B (en) | 3D printing antibacterial hydrogel wound dressing based on green in-situ reduction | |
| CN103768643B (en) | A kind of silver ion alginate sustained-release antibacterial gel and preparation method thereof | |
| CN104353105B (en) | Medical nano antibacterial gel material and preparation method thereof | |
| CN106866998A (en) | A kind of chitosan quaternary ammonium salt/carboxymethylcellulose calcium superabsorbent hydrogel and its preparation method and application | |
| CN104086706A (en) | Compound type water retention agent for enhancing germination rate of plants and preparation and application thereof | |
| CN102600493A (en) | Natural pullulan polysaccharide hydrogel wound dressing and preparation method thereof | |
| CN104174061A (en) | Chitosan-alginic acid compound antibacterial slow-release material | |
| CN108018620B (en) | Antibacterial zirconium sodium silver phosphate alginate fiber and preparation method thereof | |
| CN104606710B (en) | A kind of preparation method of high antibiotic property alginate dressing | |
| CN106065039B (en) | Preparation method of water-soluble antibacterial acrylic polymer silver salt | |
| CN113117134B (en) | Crosslinked chitosan hemostatic powder and preparation method thereof | |
| CN110272517A (en) | The synthetic method and its application of super absorbent resin microballoon with anti-microbial property | |
| CN104629072A (en) | Method for preparing high water absorbent material | |
| CN107625992A (en) | A kind of soluble dressing and preparation method thereof | |
| CN112933289A (en) | Preparation method of sodium alginate grafted tea polyphenol antibacterial dressing | |
| CN107473964B (en) | Organic nano antibacterial agent and preparation method and application thereof | |
| CN102058898B (en) | Powder with antibacterial and haemostatic effects and preparation method and applications thereof | |
| CN105560166A (en) | Gynecological external antibacterial gel with silver ions and method for preparing gynecological external antibacterial gel | |
| CN107556523A (en) | A kind of composite antibacterial material and preparation method thereof | |
| CN103815520A (en) | Cross-linked chitosan food preservative, and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181116 |